CN201654027U - Detecting device for analyzing analyte in liquid sample - Google Patents
Detecting device for analyzing analyte in liquid sample Download PDFInfo
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- CN201654027U CN201654027U CN2009201243289U CN200920124328U CN201654027U CN 201654027 U CN201654027 U CN 201654027U CN 2009201243289 U CN2009201243289 U CN 2009201243289U CN 200920124328 U CN200920124328 U CN 200920124328U CN 201654027 U CN201654027 U CN 201654027U
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Abstract
The utility model relates to a detecting device for analyzing analyte in liquid sample, which comprises a detecting cavity (716, 202, 601) for containing detecting components, a liquid-sample transfer cavity (208, 501), and a small-hole film (209, 7111) arranged between the detecting cavity and the liquid-sample transfer cavity, wherein, when the detecting device is inserted into a liquid-sample collecting cavity 101, the liquid sample in the collecting cavity enters the liquid-sample transfer cavity, but the liquid sample can not enter the detecting cavity through the film; furthermore, when a piston 102 is inserted into the liquid-sample transfer cavity, the piston leads part of the liquid sample in the transfer cavity to enter the detecting cavity through a porous film. The detecting device can be used for conducting quantitative sampling and can complete detection for one time.
Description
Technical field
The utility model belongs to the liquid sample assembling sphere, belongs to the field of collecting liquid sample and detecting analyte in the sample especially, especially detects the metabolin that whether contains the drug abuse material in the sample or the quick diagnosis of women's gestation aspect and detects.
Background technology
In recent years, pick-up unit is made the body fluid that is used for detecting the people in a large number, urine for example, the analyte in saliva or the blood, for example indicator substance of drug abuse or disease.Traditional like this pick-up unit need be collected in liquid sample to a container usually, inserts testing element in the liquid then and then takes out and read test result on (with the naked eye see or read with machine) testing element.Might allow the operator by sample contamination like this.Use this pick-up unit except being used by professional testing staff, do not had the people of professional experiences to use by some gradually, for example use in the family, this just need provide a kind of operation simpler, and testing result is pick-up unit more accurately.
Summary of the invention
On the one hand, the utility model relates to the pick-up unit of analyte in a kind of analytic liquid sample body, this device can quantitative sampling and test sample in whether have analyte.Pick-up unit comprises, is used to accommodate the test chamber of detecting element; A liquid sample transfer chamber; And aperture film that is set between test chamber and the liquid sample transfer chamber, wherein, when this pick-up unit is inserted in the liquid sample collecting chamber, the liquid sample in the collecting chamber enters in the liquid sample transfer chamber, but this liquid can not enter in the test chamber by this film; And wherein, when a piston is inserted in the liquid sample transfer chamber, piston forces the partially liq sample in the transfer chamber to enter into test chamber by this porous membrane.
In some preferred modes, aperture can be set to have surface tension of liquid, when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by the aperture on this film; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber enters in the test chamber by described aperture.Preferred, allow piston in transfer chamber, relatively move to increase pressure in the transfer chamber, and allow it greater than the set surface tension of liquid of described aperture.In other preferred modes, can also comprise a fluid passage between liquid sample transfer chamber and the collecting chamber, after the partially liq sample in the collecting chamber flow into transfer chamber by this passage, described first passage was by this piston seal.More excellent, in the time of the piston seal first passage, the pressure in the described transfer chamber is less than or equal to the set surface tension of liquid of second channel.
In the preferred mode of other, piston has the primary importance and the second place in transfer chamber; When piston was positioned at primary importance, at this moment, the fluid passage between piston seal collecting chamber and the transfer chamber allowed holding portion liquid sample in the plunger shaft simultaneously; Liquid sample can not the aperture on the film enters in the test chamber between test chamber and the transfer chamber by being arranged on; When piston moves to the second place from primary importance, piston forces the liquid sample of transfer chamber to enter into test chamber by the aperture on the film.
On the other hand, the utility model also provides a kind of detection box, comprising: a kind of pick-up unit, comprise the liquid sample transfer chamber, and test chamber wherein is provided with one deck aperture film between transfer chamber and test chamber; A liquid sample collecting chamber comprises a piston that is used for being inserted into transfer chamber; When in use, this pick-up unit is inserted in the collecting chamber, and the liquid sample in the collecting chamber flow in the transfer chamber, but can not enter by the aperture on the film in the test chamber; And wherein, when piston is inserted in the transfer chamber, contact with testing element thereby force partially liq sample in the transfer chamber to enter in the test chamber by film.
In a preferred mode, aperture can be set to have surface tension of liquid, when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by this aperture; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber can enter in the test chamber by described aperture.More preferably, the liquid sample transfer chamber can also comprise a passage, and after the partially liq sample in the collecting chamber flow into transfer chamber by this passage, described passage was by this piston seal.More excellent, in the time of the piston seal passage, the pressure in the described transfer chamber is less than or equal to the set surface tension of liquid of second channel.
Other preferred embodiment in, piston has the primary importance and the second place in transfer chamber; When piston was positioned at primary importance, the piston seal fluid passage allowed holding portion liquid sample in the plunger shaft, and simultaneously, the pressure in the plunger shaft is less than or equal to the set surface tension of liquid of aperture; When piston moves to the second place from primary importance, piston increases the pressure in the plunger shaft and allows its surface tension of liquid greater than set aperture.
On the other hand, the utility model provides the method for analyte in a kind of analytic liquid sample body, comprising: pick-up unit is inserted in the liquid sample collecting chamber; Allow the liquid sample in the collecting chamber enter in the liquid sample transfer chamber of pick-up unit, but allow liquid not enter in the test chamber by the aperture film that is arranged between test chamber and the transfer chamber by fluid passage; Allow piston be inserted in the liquid sample transfer chamber, force the liquid sample in the transfer chamber to enter in the test chamber by the aperture film that is arranged between test chamber and the transfer chamber.At one specifically more preferably in the mode, can allow the liquid sample in the test chamber contact with detecting element.In the another one embodiment, piston can be positioned at collecting chamber.
In addition, can allow piston in transfer chamber, have first and second positions; When piston was positioned at primary importance, liquid sample can not enter in the test chamber piston seal fluid passage by this aperture film; Allow piston move to the second place, thereby force the partially liq sample in the transfer chamber to enter in the test chamber by the aperture film that is arranged between test chamber and the transfer chamber from primary importance.
In the other embodiment, liquid sample transfer chamber, test chamber and aperture film can be connected as a single entity; Collecting chamber and piston can be connected as a single entity.
In the other mode, can allow aperture be set to have surface tension of liquid, allow the pressure differential of transfer chamber and test chamber be less than or equal to the set surface tension of liquid of this aperture, thereby make the liquid sample in the transfer chamber not enter test chamber by this aperture; Allow the pressure differential of transfer chamber and test chamber greater than the set surface tension of liquid of this aperture, thereby the liquid in the transfer chamber can be entered in the test chamber by described aperture.In the mode, allow piston in transfer chamber, relatively move to increase pressure in the transfer chamber.
In above all embodiments, in more concrete preferred embodiment, can also be: piston be positioned at the bottom of collecting chamber and to upper process; Piston can be arranged in the liquid sample collecting chamber and be connected as a single entity with the liquid sample collecting chamber; Transfer chamber can also be connected as a single entity with test chamber.Also have, the quantity of aperture can be 2 for one or more, 3, and 4,5 or more; Aperture diameter can be the 1-10 millimeter, can be 0.1,0.2,0.3,0.4,0.5,0.8,0.9,1,2,3,4,5 or 6 millimeter; The shape of aperture can be right cylinder shape or taper or other shapes.These devices, the detecting element that detects in box or the method can be the cross flow reagent strips, can also comprise a fetch equipment that reads test result on the detecting element.
Beneficial effect
The utility model settles the detection sample at one go, and can not pollute environment, and simple operation can realize that quick diagnosis detects family and uses.In addition, this device can detection by quantitative, can improve the accuracy and the sensitivity of detection.
Description of drawings
Fig. 1 is some specific embodiment principle of work synoptic diagram under the situation of liquid sample abundance of device of the present utility model;
Fig. 2 is the profile synoptic diagram of the sub-shown device principle of work of other specific embodiment;
Fig. 3 is a principle of work synoptic diagram in other embodiments of device of the present utility model;
Fig. 4 detects the box schematic appearance in specific embodiment of the utility model;
Fig. 5 detects the structure exploded perspective view of box for Fig. 4;
Fig. 6 is the perspective view of gathering-device shown in Figure 4;
Fig. 7 is the perspective view of pick-up unit shown in Figure 4;
Fig. 8 is the cross-sectional view of pick-up unit shown in Figure 7;
Fig. 9 is another cross-sectional view of detection part shown in Figure 7;
Figure 10 is a small structure enlarged diagram in the examples of implementation;
Figure 11 is a small structure enlarged diagram in another examples of implementation;
Figure 12 is the medium and small pore passage structure enlarged diagrams of another examples of implementation;
Figure 13 is inserted in the collecting chamber for pick-up unit shown in Figure 4 but piston also is not inserted into the cross-sectional view in the transfer chamber;
Figure 14 is an A part-structure enlarged diagram shown in Figure 13;
Figure 15 forces liquid sample to enter the Operation Profile structural representation of test chamber by aperture 713 for the fluid passage of the transfer chamber shown in Figure 14 is moved in transfer chamber by the piston seal back piston;
Figure 16 is a B part-structure enlarged diagram shown in Figure 15;
Description of reference numerals:
Pick- up unit 20,60,71; Detect box 70,90,56; Detecting element 40,717; Lid 711; Test chamber 202,601,716; Aperture film 209,7111; Aperture 203,205,713,714; Aperture inside surface 2003, tapered openings 713, back taper aperture 714, transfer chamber 208, plunger shaft 201,501,712; Fluid passage or plunger shaft opening 503,204,715; One end 604 of test chamber, display window 710 as a result, piston 102,722, collecting chamber opening 723, collecting chamber 721,101, bottom 724,104, fetch equipment 718, O-ring seal 105,726; Barrier element 719, screw thread 727.
Embodiment
In the following detailed description, the explanation of accompanying drawing and corresponding character only is the mode that illustrates that by way of example the utility model can actable specific concrete scheme.We do not get rid of the utility model can also be in any other embodiment in the utility model claim scope.
On the one hand, the utility model provides the pick-up unit of analyte in a kind of tracer liquid sample.This device can detect chemical examination and not pollute other remaining liquid samples liquid sample.And this detection is to finish in a step, does not need the complicated operations step.This pick-up unit 20 comprises: the test chamber 202 that is used to accommodate detecting element; A liquid sample transfer chamber 208; With one test chamber and the separated aperture film 209 of liquid sample transfer chamber; Wherein, when this pick-up unit being inserted in the liquid sample collecting chamber 101, in the liquid sample 30 influent sample transfer chamber 208 in the collecting chamber 101, but can not enter in the test chamber by this film 209; And wherein, when a piston 102 is inserted in the liquid sample transfer chamber 208, piston 102 forces the partially liq sample 301 in the transfer chamber 208 to enter into test chamber 202 by this porous membrane 209.
Showed an embodiment of the present utility model as Figure 1A-1D.Now describe in detail.As Figure 1A, showed the liquid-sample collection device 10 in embodiment of the utility model, comprise a chamber 101 of collecting liquid sample, encircled a city by sidewall and bottom 104 in this chamber and an end opening is used for admitting or accommodating liquid sample, and the other end is closed.One piston 102 is positioned at the bottom 104 of collecting chamber and to upper process.As Figure 1B, showed that a pick-up unit 20 in embodiment of the utility model comprises a test chamber 202, this test chamber can be used for holding detecting element 40 and the liquid sample of accepting from transfer chamber, with a liquid sample transfer chamber 208, between test chamber 202 and liquid sample transfer chamber 208 one deck hole film 209 is set, this film is separated test chamber 202 and liquid sample transfer chamber 201.Transfer chamber can be specially plunger shaft 201 in Figure 1B, this plunger shaft one end opening provides and allows liquid enter the fluid passage 204 of plunger shaft, the other end is specially two apertures 203 and 204 by the narrow meshed diaphragm seal of one deck in Figure 1B, these two apertures connect plunger shaft and test chamber.When in use, pick-up unit is inserted in the collecting chamber 101 in the gathering-device, the liquid sample in the collecting chamber enters in the transfer chamber by passage 204, but liquid can not enter in the test chamber 202 by film 209; When the piston in the collecting chamber 102 is inserted in the transfer chamber 208, be specially among Fig. 1 in the plunger shaft 201, piston forces the partially liq sample to enter in the test chamber 202 by the aperture 203,205 on the film 209, shown in Fig. 1 C.In a preferred mode,, enter liquid sample in the test chamber and contact with detecting element and chemically examine detection, as Fig. 1 D if in test chamber, comprise a detecting element 40.
In other concrete optimal ways, size or shape that aperture can be set allow aperture have certain surface tension of liquid, for example allow the interior diameter of aperture be 0.5 millimeter.After having collected the certain amount of fluid sample in the collecting chamber, shown in Figure 1A, a large amount of liquid samples is collected in the collecting chamber, then pick-up unit 20 is inserted in the collecting chamber 101, in insertion with near in the process of piston 102, partially liq sample in the collecting chamber enters in the plunger shaft 201 by passage 204, air in the plunger shaft is by aperture 203 or 205 simultaneously, be rejected to outside the plunger shaft, because test chamber and atmosphere communicate, the pressure of plunger shaft interior 201 and test chamber 202 equates that pressure differential is almost nil, less than the surface tension of liquid of predefined aperture.Along with plunger shaft continue move down, air in the plunger shaft has been arranged gradually, and liquid sample 30 is full of whole plunger shaft 201, and this moment, liquid contacted with air at the aperture place, because the existence of aperture, liquid just descend the effect in hole to produce certain surface tension of liquid down; Along with plunger shaft 201 continue move down, the liquid level in the plunger shaft is lower than the liquid level (when liquid sample is relatively sufficient or more a large amount of) of collecting chamber 101 gradually.Along with plunger shaft continues to move down, the opening of plunger shaft, promptly passage 204, with piston 102 cooperations and by piston seal, because piston seal passage 204, stoped that more liquid sample enters in the plunger shaft in the collecting chamber, this in time piston be positioned at primary importance in the plunger shaft.In this time,,, thereby make way for aperture 203 or 205 subsurface pressure increases as Fig. 1 C because two liquid surfaces have a height difference H.But owing to be provided with the size or the shape of aperture, effect produces a surface tension of liquid between liquid and the air, and this tension force can be set to larger than the pressure that produces owing to liquid level difference H, this time, liquid sample in the transfer chamber can not enter in the test chamber from aperture 203,205.Along with plunger shaft 201 continues to move down, move to the second place from primary importance, the piston 102 that is arranged in collecting chamber is done further mobile in plunger shaft, liquid in the piston compressing plunger shaft 201 increases by the pressure of aperture lower surface, thereby broken the set surface tension of liquid of aperture, allow liquid sample in the plunger shaft by aperture 203 or 205, enter in the test chamber and react with testing element 202, this moment, piston was positioned at the second place of plunger shaft.
In some other specific embodiment, after holding a part of liquid sample in the plunger shaft, still allow piston and plunger shaft maintenance sealing state in the process that can allow piston 101 move at seal fluid passage 204 and in plunger shaft, can stop the liquid sample in the collecting chamber to enter in the plunger shaft like this, reach the purpose of quantitative sampling, in order to reach better sealing effectiveness, outside surface at piston is provided with one or several plastics, rubber or silica gel sealing ring, for example round section joint ring 105, as Figure 1A.Can certainly not allow piston seal passage 204, but along with plunger shaft and piston than relative motion faster, allow the liquid in the piston compressing plunger shaft produce the pressure of moment, this instantaneous pressure can be broken the intrinsic surface tension of liquid that aperture is set up and allow the liquid in the plunger shaft enter test chamber.
Except above concrete mode, the aperture film with this character can be selected arbitrarily, for example selects those films with micro hole, cellulose nitrate film for example, nylon film or filter paper, glass fibre or the like.Certainly can also be plastic sheet with micro-aperture.In some preferred embodiments, test chamber 202 and transfer chamber 201 public faces, 209 on Figure 1B for example, this face is separated test chamber and transfer chamber, some apertures 203 or 205 are set, these aperture communication with detection chamber and transfer chamber on this face 209.In a preferred mode, pick-up unit is an once injection moulding, and public isolation surface 209 is a plastic sheet, and thickness is approximately 1.5 millimeters, and some apertures are set on plastic sheet.In the other examples of implementation, the surface tension of liquid that aperture had on the film is set, liquid surface can come to be provided with arbitrarily as required, for example changes the internal diameter size of aperture, the perforate degree of depth of aperture, the shape of aperture or these combination of features.The quantity of aperture can be 2 for one or more, 3, and 4,5 or more; Aperture diameter can be the 1-5 millimeter, can be 0.1,0.2,0.3,0.4,0.5,0.8,0.9,1,2,3,4,5 or 6 millimeter; The shape of aperture can be right cylinder shape or taper or other shapes; The thickness of aperture is the 0.1-10 millimeter, can be 0.1,0.2,0.5,1.0,1,3,5,7,9,2,4 or 6 millimeters etc.In specific embodiment, shown in Figure 10-12, aperture is tubular 203, and the interior diameter of aperture is 0.5 millimeter, is 1.5 millimeters deeply, also can be tapered aperture 713, Figure 11, or back taper aperture 714, Figure 12.Change the size of these apertures, the mode of the shape or the degree of depth has a variety of, the film of micro-aperture that can be by selecting different materials, filter paper, glass fibre etc.Also have a variety of test chamber and the separated mode of transfer chamber, for example passed through the once injection moulding hollow circular cylinder before this, his both ends open, in the right cylinder position intermediate film that one deck has micro hole is set then, for example a layer thickness is 1.5 millimeters a filter paper, this layer film is separated into two chambeies to this right cylinder, test chamber 202 and transfer chamber 201.
Fig. 2 A-2D has showed another concrete embodiment of the utility model.Now describe in detail.As Fig. 2 A, showed the liquid-sample collection device 10 in embodiment of the utility model, comprise a chamber 101 of collecting liquid sample, this chamber is surrounded by sidewall and bottom and an end opening is used for admitting or accommodating liquid sample, and the other end is closed.One piston 102 is positioned at the bottom of collecting chamber and to upper process.As Figure 1B, showed that a pick-up unit 20 in embodiment of the utility model comprises a test chamber 202, this test chamber can be used for holding detecting element 20 and the liquid sample of accepting from transfer chamber, with a plunger shaft 201, between test chamber 202 and plunger shaft 201 one deck filter paper 209 is set, this filter paper is separated test chamber and liquid sample transfer chamber.Liquid sample in collecting chamber 101 is less, when being inserted into detection part 20 in the collecting chamber, because liquid sample is less, plunger shaft 201 is by partially filled liquid sample, air in the piston is discharged to outside the chamber by the intrinsic micro hole of filter paper, and the liquid surface in plunger shaft and the liquid level of collecting chamber are contour, and the air pressure of air pressure in the plunger shaft and test chamber equates at this moment, pressure differential is zero, Fig. 2 C.Along with pick-up unit continues to move down, piston seal fluid passage 204 allows the liquid volume in the plunger shaft 201 no longer increase.Plunger shaft further moves down, and piston impels the liquid phase in the plunger shaft to move making progress, and exists the surplus air in the plunger shaft to pass through filter paper 209, is discharged from outside the chamber.Do further in plunger shaft when piston and to move, impel the liquid in the plunger shaft to enter in the test chamber 202 by the micro hole on the filter paper.
Fig. 4-16 is some examples of implementation more specifically of the utility model.In an object lesson, detect box 70 and comprise gathering-device 72 and pick-up unit 71.Gathering-device 72 comprises the collecting chamber 721 of an end opening 723 and the other end 724 sealings, at sealing one end 724 of collecting chamber, i.e. and bottom, the piston 722 of a projection is set, this piston is fixed on the collecting chamber bottom, and Fig. 6 is provided with an O-ring seal 726 in the top of piston extension.Pick-up unit 71 comprises test chamber 716 and plunger shaft 712, and the shared bottom 7111 of test chamber and plunger shaft is provided with two apertures 714,713 on 7111, allows aperture communication with detection chamber and plunger shaft, Fig. 5 and Fig. 7; Make being shaped as of aperture cylindrical, Figure 10, the diameter of two apertures are respectively 0.5 millimeter, and the degree of depth is 1 millimeter.The position of piston and plunger shaft is set, when piston is inserted into collecting chamber, can allows piston over against plunger shaft; The height of piston and the degree of depth of plunger shaft are set, piston can all be inserted in the plunger shaft; The diameter of piston and plunger shaft is set simultaneously, piston 722 can just be inserted in the plunger shaft 712 can allow simultaneously the opening 715 that piston can well the packed-piston chamber.In present embodiment, test chamber 716, plunger shaft 712 and the bottom 7111 that they are public are plastic material and disposable mold injection molding; Collecting chamber 721, the piston 722 of bottom and projection are plastic material and disposable mold injection molding.Certainly, in other specific embodiment, piston and collecting chamber can be connected as a single entity or disposable mold injection molding; Also can be to make then respectively to bond together by glue.Test chamber and plunger shaft also can be moulding respectively, and between is provided with one deck aperture film then, and the aperture film is separated test chamber and transfer chamber like this.When in use, after pick-up unit 71 is inserted into collecting chamber 721, the liquid that is arranged in collecting chamber enters into plunger shaft by plunger shaft opening 715, this moment, piston also was not inserted in the plunger shaft, gas in plunger shaft is excluded by aperture, because aperture has surface tension of liquid, the liquid in the plunger shaft can not enter in the test chamber by aperture, Figure 13,14.When piston is inserted in the plunger shaft, piston increases by the pressure in the plunger shaft, has broken the surface tension that the aperture place forms, and forces liquid sample to enter test chamber, Figure 15 and 16.Can also comprise a testing element 717 in test chamber, can also comprise the fetch equipment 718 of testing result on the read test element, fetch equipment directly is presented at the result who reads on the LCD screen 710, Fig. 8.After liquid sample entered test chamber, testing element contact liq sample and reaction detection obtained testing result, by fetch equipment, testing result directly are presented on the lcd screen.As Chinese utility application, application number 200410045273.4,200410045275.3 disclosed all embodiments about testing element and fetch equipment can be used to the analyte that comes in the utility model in the tracer liquid sample and the result of laboratory test on the read test element in 200410063910.0.
In a more excellent embodiment, the lid 711 that test chamber 716, plunger shaft 712 and being used for covers the collecting chamber opening is connected one, and as Fig. 8, shown in Figure 13-16, collecting chamber and lid are provided with screw thread 727 respectively.When on the opening that lid is covered collecting chamber the time, the rotation lid moves to low level by lid from a high position, drives the test chamber that is connected as a single entity with lid and plunger shaft from moving down, thereby finishes the sampling and the transfer of liquid sample.For example shown in Figure 13-16, in the time of the collecting chamber opening that cover cap is incorporated on the gathering-device, the plunger shaft that is connected as a single entity with lid is inserted in the collecting chamber, at this moment, liquid sample in the collecting chamber enters in the plunger shaft 712 by plunger shaft opening 715, and the gas in the plunger shaft is rejected in the test chamber.Along with lid further rotates, Figure 15 allows the distance that lid moves and the height of piston equate, like this, in the time of lid sealing collecting chamber opening, piston is full of whole plunger shaft, and piston forces the liquid in the plunger shaft almost all to enter in the test chamber by aperture.
In some cases, because the continuity and the transience of sampling operation, the liquid sample that comes out from aperture sometimes is " injection " shape and enters in the test chamber.In order to prevent that these liquid samples are ejected on other elements that are positioned at test chamber, a protecting component is set above aperture, this element can be ejected on other elements by barrier liquid, does not influence liquid sample again simultaneously and contacts with testing element.Figure 14 institute for example is provided with one and falls " U " shape or " ⊥ " structure of falling above aperture, this structure can allow the liquid sample that is " injection " shape slowly enter in the test chamber and contact and can not be ejected on other element with testing element.When particularly containing electronic component in the test chamber, utilize protecting component can allow electronic component can not destroy some functions more safely because of the contact liq sample.
In the preferred mode of other, the size of aperture is set when utilization, the shape or the degree of depth are provided with capillary the time, preferably pick-up unit are inserted into before the collecting chamber, allow the inside surface 2003 of aperture, 7113, keep dry, can obtain desirable surface tension like this, because show by experiment, when having adhered to one deck hydrone on the little internal surface of hole, may reduce the surface tension that produces at the aperture place between liquid and the air.Simultaneously, in order to obtain better effect, allow pick-up unit be arranged to disposable and can not reuse.
Showed the utility model other specific embodiments as Fig. 3.In specific embodiment, the gathering-device 50 that the utility model provides comprises a liquid sample collecting chamber 101 and is positioned at the plunger shaft 501 of collecting chamber bottom, Fig. 3 A.Pick-up unit 60 comprises a test chamber 601, an end opening of test chamber, and the other end is sealed by the film 209 that one deck has aperture.In a concrete mode, test chamber bottom end 604, comprise two apertures 602,603, whole test chamber can be for cylindrical, the opening 503 that comprises end 604 of aperture and plunger shaft cooperates and can packed-piston chamber 501, Fig. 3 B, and whole test chamber and narrow meshed heterodoxy all are plastic material and injection moulding disposal molding.The end that plunger shaft 501 and test chamber have aperture constitutes transfer chamber jointly.In use, when collection in the collecting chamber had liquid sample, liquid sample can be by opening one end 503 of piston, and promptly the fluid passage of transfer chamber enters in the plunger shaft 501.When test chamber is inserted in the collecting chamber, bottom 604 1 ends of test chamber at first contact with liquid sample.Though an end of test chamber bottom has two apertures, owing to be provided with the shape or the size of aperture, for example allow the interior diameter of each aperture be 0.3 millimeter, allow these apertures under the effect of liquid, produce surface tension, this surface tension is enough to stop the liquid sample in the collecting chamber to enter in the test chamber, even be lower than in test chamber bottom end 604 under the liquid level of collecting chamber, promptly there is difference in height, surface tension of liquid on the aperture still can stop the liquid sample in the collecting chamber to enter in the test chamber Fig. 3 C.Along with test chamber further moves, test chamber has the opening 503 in an end 604 packed-piston chambeies of aperture, thereby stop the liquid in the collecting chamber 101 to enter in the plunger shaft 501, allow the liquid sample volume in the plunger shaft no longer increase, can reach the purpose of quantitative sampling.Still can allow the liquid sample in the plunger shaft not enter in the test chamber by aperture this time, and this moment, piston was in primary importance.When piston moves to the process of the second place from primary importance, be that piston continues to move down, because the effect of external force, thereby allow the pressure increase at aperture place break the surface tension that is set at the aperture place, allow liquid sample in the plunger shaft by aperture 602,603 enter 601 li of test chamber, Fig. 3 C.In test chamber, sample and the testing element that is positioned in the test chamber react.
On the other hand, the utility model provides the method that whether contains analyte in a kind of tracer liquid sample.This method is inserted into pick-up unit in the liquid sample collecting chamber; Allow the liquid sample in the collecting chamber enter in the liquid sample transfer chamber of pick-up unit, but allow liquid not enter in the test chamber by the aperture film that is arranged between test chamber and the transfer chamber by fluid passage; Allow piston be inserted in the liquid sample transfer chamber, force the liquid sample in the transfer chamber to enter in the test chamber by the aperture film that is arranged between test chamber and the transfer chamber.More specifically, as shown in Figure 1, pick-up unit 20 is inserted in the liquid sample collecting chamber 101, liquid sample in the collecting chamber 101 enters into liquid sample transfer chamber 201, at this moment, liquid sample can not enter in the test chamber by being arranged on the aperture film 209 that is provided with between test chamber 202 and the transfer chamber 201; Allow piston 102 be inserted in the transfer chamber 201, piston forces the partially liq sample to enter into test chamber by aperture film 209.In the concrete embodiment shown in Fig. 4-16, detection method comprises provides a pick-up unit 71, comprise test chamber 716 and transfer chamber 712, a plastic sheeting 7111 that has aperture 713,714 is set between test chamber and transfer chamber, and it is 0.5 millimeter that described aperture interior diameter is set, height is 1.5 millimeters, as Figure 10.Provide a gathering-device 702 to comprise collecting chamber 721 and be positioned at piston 722 in the collecting chamber, this piston by the bottom 724 of collecting chamber to upper process; Pick-up unit is inserted in the collecting chamber, allow the liquid in the collecting chamber enter in the transfer chamber 712 by fluid passage 715, allow the fluid passage of piston seal transfer chamber and collecting chamber then, piston is arranged in the primary importance of transfer chamber, and this moment, liquid sample can not enter test chamber from transfer chamber by the film of aperture; Allow piston be inserted in the transfer chamber, move to the second place from primary importance, force liquid sample to enter test chamber by the film of aperture from transfer chamber, till allowing piston move to can not to move, all liq sample in the transfer chamber is whole oppressed entering in the test chamber almost always.
In other specific embodiment, after piston is inserted into transfer chamber and forces liquid sample to enter test chamber by aperture, no longer allow the relative transfer chamber of piston moving to travelling backwards.For example, when rotating by clockwise lid, after allowing plunger shaft move up and forcing liquid sample in the plunger shaft to enter test chamber by aperture with respect to piston, inhour is rotated lid again, can not allow the liquid sample backflow that enters test chamber enter in the transfer chamber like this, thereby may pollute the liquid sample in the collecting chamber.
" sample " that the utility model refers to refer to whether needs chemical examinations exists and (or) analyze any material of analyte concentration, maybe need to determine whether one or more samples exist and (or) material of the analyte of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be liquid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and make sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with the suitable solution of dilution one class.Sample can be macerated, freezing and thaw, perhaps other extracting method form liquid samples.Remaining particulate material can use traditional method such as filtration or precipitation to remove.
The analyte that the utility model refers to can be " drug abuse " (DOA) or other have interested material in the sample." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, RochePharmaceuticals, Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Claims (19)
1. the pick-up unit of analyte in the analytic liquid sample body comprises: a test chamber that is used to accommodate detecting element; A liquid sample transfer chamber; And one be set at aperture film between test chamber and the liquid sample transfer chamber; Wherein, when this pick-up unit is inserted in the liquid sample collecting chamber, the liquid sample in the collecting chamber enters in the liquid sample transfer chamber, but this liquid sample can not enter in the test chamber by described film; And wherein, when a piston is inserted in the liquid sample transfer chamber, this piston forces the partially liq sample in the transfer chamber to enter into test chamber by this porous membrane.
2. device as claimed in claim 1, wherein, described aperture is set to have surface tension of liquid, and when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by this aperture; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber can enter in the test chamber by described aperture.
3. device as claimed in claim 1 wherein, comprises a fluid passage between described liquid sample transfer chamber and the collecting chamber, after the partially liq sample in the collecting chamber flow into transfer chamber by this passage, described first passage was by this piston seal.
4. device as claimed in claim 3, wherein, described aperture is set to have surface tension of liquid, and in the time of the described fluid passage of piston seal, the pressure in the described transfer chamber is less than or equal to the set surface tension of liquid of aperture.
5. device as claimed in claim 3, wherein, piston has the primary importance and the second place in transfer chamber; When piston is positioned at primary importance, the piston seal first passage, holding portion is from the liquid sample in the collecting chamber in the transfer chamber simultaneously, and at this moment, liquid sample can not enter in the test chamber by the aperture film; When piston moves to the second place from primary importance, piston enters in the test chamber by the aperture film by liquid.
6. as the described device of one of claim 1-5, wherein, piston is arranged in the liquid sample collecting chamber.
7. as the described device of one of claim 1-5, wherein, transfer chamber and test chamber are connected as a single entity.
8. as the described device of one of claim 1-5, wherein, transfer chamber, test chamber and aperture film are integrated injection molding.
9. as the described device of one of claim 1-5.Wherein, the quantity of aperture is one or more.
10. as the described device of one of claim 1-5, wherein, aperture diameter be the 0.1-5 millimeter.
11. device as claimed in claim 1, wherein, this device also comprises a detecting element that is arranged in test chamber.
12. device as claimed in claim 11, wherein, this device also comprises a fetch equipment that reads test result on the detecting element.
13. device as claimed in claim 11, wherein, testing element is the cross flow reagent strip.
14. one kind is detected box, comprising: a pick-up unit, comprise the liquid sample transfer chamber, test chamber wherein is provided with one deck aperture film between transfer chamber and test chamber; A liquid sample collecting chamber, this collecting chamber comprise a piston that is used for being inserted into transfer chamber; When in use, this transfer chamber is inserted in the collecting chamber, and the liquid sample in the collecting chamber flow in the transfer chamber, but this liquid sample can not enter in the test chamber by the aperture film; And wherein, when piston is inserted in the transfer chamber, piston forces the partially liq sample in the transfer chamber to enter in the test chamber by the aperture film.
15. detection box as claimed in claim 14, wherein, described aperture is set to have surface tension of liquid, when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by this aperture; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber enters in the test chamber by described aperture.
16. detection box as claimed in claim 15, wherein, described liquid sample transfer chamber also comprises a fluid passage, and after the partially liq sample in the collecting chamber flow into transfer chamber by this passage, described passage was by this piston seal.
17. detection box as claimed in claim 16, wherein, in the time of the piston seal first passage, the pressure in the described transfer chamber is less than or equal to the set surface tension of liquid of aperture.
18. detection box as claimed in claim 16, wherein, piston has the primary importance and the second place in transfer chamber; When piston was positioned at primary importance, the piston seal fluid passage allowed and holds partially liq sample from collecting chamber in the plunger shaft, and simultaneously, liquid sample can not enter in the test chamber by the aperture film; When piston moves to the second place from primary importance, piston forces liquid to enter in the test chamber by the aperture film.
19. detection box as claimed in claim 14, wherein, piston is positioned at the bottom of collecting chamber and to upper process.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009201243289U CN201654027U (en) | 2009-07-09 | 2009-07-09 | Detecting device for analyzing analyte in liquid sample |
US13/394,759 US9327283B2 (en) | 2009-07-09 | 2010-07-09 | Device and method for analyzing analyte in liquid samples |
PCT/CN2010/001020 WO2011003281A1 (en) | 2009-07-09 | 2010-07-09 | Device and method for analyzing analyte in liquid sample |
EP10796658.2A EP2451576B1 (en) | 2009-07-09 | 2010-07-09 | Device and method for analyzing analyte in liquid sample |
US15/135,418 US20160310938A1 (en) | 2009-07-09 | 2016-04-21 | Device and method for analyzing analyte in liquid sample |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2009201243289U CN201654027U (en) | 2009-07-09 | 2009-07-09 | Detecting device for analyzing analyte in liquid sample |
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CN201654027U true CN201654027U (en) | 2010-11-24 |
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CN2009201243289U Expired - Lifetime CN201654027U (en) | 2009-07-09 | 2009-07-09 | Detecting device for analyzing analyte in liquid sample |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101943696A (en) * | 2009-07-09 | 2011-01-12 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN102012421A (en) * | 2009-09-07 | 2011-04-13 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN104641241A (en) * | 2012-07-31 | 2015-05-20 | 爱-森斯株式会社 | Biochemical analysis cartridge having improved operability |
-
2009
- 2009-07-09 CN CN2009201243289U patent/CN201654027U/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101943696A (en) * | 2009-07-09 | 2011-01-12 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN101943696B (en) * | 2009-07-09 | 2014-05-07 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN102012421A (en) * | 2009-09-07 | 2011-04-13 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN102012421B (en) * | 2009-09-07 | 2014-04-09 | 艾博生物医药(杭州)有限公司 | Detection device for analyzing analyte in liquid sample |
CN104641241A (en) * | 2012-07-31 | 2015-05-20 | 爱-森斯株式会社 | Biochemical analysis cartridge having improved operability |
CN104641241B (en) * | 2012-07-31 | 2016-06-01 | 爱-森斯株式会社 | There is the biochemical analysis box of the operability of improvement |
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