CN206945339U

CN206945339U - A kind of sample collection device

Info

Publication number: CN206945339U
Application number: CN201620952545.7U
Authority: CN
Inventors: 陆维克; 陈金树; 高飞
Original assignee: Hangzhou Ao Tai Bioisystech Co Ltd
Current assignee: Hangzhou Aotai Biotechnology Ltd By Share Ltd
Priority date: 2016-08-26
Filing date: 2016-08-26
Publication date: 2018-01-30
Anticipated expiration: 2026-08-26

Abstract

The utility model provides a kind of sample collection device, it is characterised in that the collection device includes sampling element, the lid element being connected as a single entity with sampling element, and accommodates the storage chamber of sampling element, and described storage chamber surrounds including opening, side wall and bottom；Described storage chamber bottom includes the first breakable element；The breakable element can be punctured element and puncture.Using the collection device of the utility model, a variety of different samples can be collected.

Description

A kind of sample collection device

Technical field

It the utility model is related to a kind of sample collection device, the especially collection in quick diagnosis field and detection fluid-like The device of analyte in this.

Background technology

Be presently used for detect sample in whether the detection means containing analyte, be largely used to hospital or family In, these detection means for being applied to quick diagnosis include one or more detection reagent bars, such as early pregnancy detection, drug abuse Detection etc..The detection means of this quick diagnosis is very convenient, can be at one minute, or at most ten minutes or so are detecting Testing result is obtained on reagent strip.

Need to detect fluid sample, be necessarily required to convection body flow samples and be collected, then could be detected.Although at present There is different collection devices or equipment to different samples, still, it appears that also without the unified sample for adapting to different samples Product collection device.For the sample after collection, if not anxious immediately chemically examined, it is necessary to sample is transported, store, or Person is chemically examined again after placing a period of time, still has many problems to need to solve.In the conventional technology, when collection device is received Collection have sample after, often from collection device take out sample segment chemically examined, then collection device otherwise be continuing with, It is not dropped directly.Meeting generation environment pollution is directly abandoned, also increase uncertainty is abandoned in addition, since it is desired that tracing its process Necessity, detection and collect and separate different device, add the difficulty of trace back process.

For some above-mentioned technical problems, therefore need to make improvements, there is provided approach in addition is solved can be with The deficiency of existing conventional art, so as to reach the convenience of collection, the certainty of detection, it can facilitate the sum of detection means The trackability of supporting collection device.

Utility model content

For the above situation, the defects of to overcome prior art, the purpose of this utility model, which is to provide, a kind of collects sample The device of product, the collection, storage and transport of various different samples can be individually carried out using the device, when needs are examined When survey, collection device is coordinated with detection means and is used together, convenient detection.After the completion of detection, collection device and inspection Survey device to be integrated, can continue to keep, can abandon together, ensure that the certainty and easiness of retrospective, in addition Avoid polluting environment.

On the one hand, the utility model provides a kind of sample collection device, and the collection device includes a sampling element, with taking The first lid element that sample element is connected as a single entity, and the storage chamber of sampling element is accommodated, described storage chamber includes opening, side Wall and bottom.

In some modes, storage chamber includes the first breakable element, and the breakable element can be punctured element and puncture.

In some preferable modes, the first breakable element is located at the bottom of storage chamber, when the first breakable element is punctured When, storage chamber is changed into blow-by state from sealing.Or after allowing the first breakable element to be punctured, positioned at the liquid of storage chamber Body is flowed out automatically from storage chamber or impassive outflow.The liquid sample of outflow enters the test that test chamber carries out analyte Or chemical examination.

In some preferable modes, storage chamber includes the reagent of processing sample, and the reagent can be the state with solution In the presence of can also be dry reagent (such as the form such as powder, granule).When the sample of collection is dry or solid-state, semisolid When, the reagent for handling sample can be existed as a solution, and so, these are not that the sample of solution state can be molten Solution is suspended in the solution, and the analyte in sample is just dissolved in the reagent solution of processing sample.When the sample of collection This is when be liquid, and the reagent for handling sample can be dry state, such as the form of powder, particle, particulate, tablet, this The dry reagent of sample liquid aspect originally dissolution process sample.

In some preferable modes, described lid includes the second breakable element, and the breakable element can be punctured element Puncture.

In some preferable modes, the first lid is used for the opening of sealed storage chamber, while lid sealed opening, Sampling element is inserted into storage chamber.

In some preferable modes, after the second breakable element on the first lid is punctured, puncturing elements are retained in In first lid.In some preferable modes, the puncturing elements for puncturing the first breakable element drive the first lid to rotate.

In some preferable modes, first lid includes the passage being connected with storage chamber, and one end of passage is with depositing Storage chamber communicates, and the other end is sealed by the second breakable element.

In some preferable modes, sampling element is connected as a single entity by connecting rod and the first lid element.It is excellent at some In the mode of choosing, sampling element includes the material for absorbing liquid, such as sponge, filter paper, foam, film etc. can absorb liquid Material.The liquid samples such as saliva, urine, sweat can be collected using absorbent material.

In some preferable modes, sampling element includes spoon shape structure, can be solid to some using the structure as spoon Body sample sample, and can quantify sampling number.

In some preferable modes, sampling element includes suction pipe, and the suction pipe can be extruded so as to draw certain liquid Body sample.In preferable mode, suction pipe is capillary syring, and capillary force automatic sucking sample can be relied on by capillary syring This, such as blood, blood plasma, serum, whole blood sample.

In some preferable modes, sampling element includes any combination of groove, hole, hole or above structure, using this The structure of sample can take solid or sticky sample, such as fecal sample, so allow solid-state or semi-solid samples filling slot, hole Or pore structure, so as to obtain the quantity of purpose sample or weight.Described sampling element is water adsorbent element.

In some preferable modes, sampling element is removably connected as a single entity structure with the first lid.So, Using same cover body structure, but sampling element can according to different samples or different requirements you, carry out any group Close, such as the first lid is the same, when needing to take saliva sample, saliva absorption heads are arranged on the first lid, so as to group Saliva absorption heads are combined into, when needing to take fecal sample, remove saliva absorption heads, installation carries spoon shape structure or groove The sampling element of structure.So convenient to change at any time, equally, the first cover body structure is relatively fixed, the various change of sampling element, and one Covering collection device can be according to the different pairs of sampling for requiring to carry out a variety of different samples.

On the other hand, a kind of detection means for detecting analyte in sample, it is characterised in that the device includes accommodating The chamber and test chamber of collection device, wherein, the chamber of the receiving collection device includes side wall and bottom and opening, and for close Second lid of Fengkai mouth, wherein the host cavity bottom include being used for the first puncturing elements for puncturing collecting chamber.

Preferably, collection device includes storage chamber, and storage chamber includes the frangible member easily punctured by described puncturing elements Part.Preferably, the second described lid includes the second puncturing elements.Preferably, the first described puncturing elements are located at host cavity Bottom simultaneously raises up, and the puncturing elements are sharp puncturing elements.Preferably, it is described to include one or more in test chamber Individual testing element, test chamber and host cavity fluid connection.Preferably, host cavity can accommodate whole collection device.Preferably, institute The collection device stated includes storage chamber, includes breakable element in the bottom of storage chamber, described to puncture the first of collecting chamber and puncture Element opens storage chamber by puncturing breakable element.Preferably, described collection device also includes the first of sealed storage chamber Lid, also includes another breakable element on first lid, and the breakable element can be pierced by the puncturing elements on the second lid It is broken.Preferably, described sample is excrement, whole blood, urine, saliva, blood plasma or serum sample.

On the other hand, the utility model provides a kind of detection means, the device include the host cavity for accommodating collection device and Test chamber, wherein, the chamber of the receiving collection device includes side wall and bottom and opening, and for sealing host cavity opening Second lid.In some preferable modes, the chamber for accommodating collection device punctures member including puncturing the first of the first breakable element Part.Preferably, the first puncturing elements are positioned at the bottom for the chamber for accommodating collection device.In some preferable modes, the second lid Including the second puncturing elements for puncturing the first lid breakable element.In some preferable modes, first and second is frangible Element is the element being easily broken or the element being easily punctured, these breakable elements can be film, glass, adhesive sticker, Plastic film, plastic tab etc..Corresponding, the first puncturing elements and the second puncturing elements are with respect to the first and second breakable elements Sample rigidity is strong or sharp, is so easier puncturing, smashing, piercing through the first and second breakable elements.It is such to be arranged on Those of ordinary skill in the art easily realize that concrete mode has a variety of selections.

In some preferable modes, in collection device is implanted to the chamber for accommodating collection device, the of collection device Corresponding first puncturing elements of one breakable element.This correspondence can be contact of second breakable element with the second puncturing elements, or The breakable element of person second and the second puncturing elements are in relative position, in first frangible and the second puncturing elements move toward one another mistake Cheng Zhong, contact and puncture.In some preferable modes, when collection device be implanted to accommodate collection device chamber in when Wait, during being placed into the chamber for housing collection device, or after process, the second breakable element and the second puncturing elements On the same axis, thus them can be allowed to contact and puncture the second breakable element.

In some preferable modes, in some preferable modes, collection device is inserted into, is implanted into, being put into detection When in the host cavity of device, the first lid of collection device and the register of host cavity or the position for being slightly above opening Put.So, when need with the second lid come the conjunction host cavity opening when, covered tightly with the rotation of lid, the second lid Upper the first puncturing elements it is corresponding, with further covering, the first puncturing elements puncture the first breakable element.Certainly at this During conjunction, collection device in the host cavity of detection means also with moving downward, so as to allow the second puncturing elements to puncture Second breakable element.So as to discharge the sample in collection device (such as liquid sample or solid sample) into host cavity. In in some preferable modes, when collection device is inserted into host cavity, first punctures and the second puncturing elements and second It is frangible and first is frangible on the same straight line of essence.Preferably, the axis that straight line is host cavity is gone back.Preferably, host cavity Axis and detection means axis line overlap.

In some preferable modes, detection means also includes test chamber.Test chamber is used to place testing element, test chamber With host cavity fluid connection.For example, the bottom of test chamber connects with the bottom liquid of host cavity, so from collection device outflow Sample is entered in host cavity, the sample in host cavity can enter test chamber bottom, so as to the survey positioned at test chamber Element contact is tried, so as to complete the detection of analyte in sample.

In some preferable modes, testing element is lateral flow element, and fluid sample is on the testing element with hair Thin action flow.

In some modes, the utility model provides a kind of system collected and detect analyte in sample, and this is System includes collection device and detection means.The different embodiments of for example foregoing all collection devices of described collection device, institute The detection means stated is the different embodiments of foregoing all detection means.

On the other hand, the utility model provides a kind of method for detecting analyte in sample, and this method provides a kind of Collection device and detection detection means, wherein collection device, which includes the collection device, includes a sampling element, with sampling element The first lid element being connected as a single entity, and the storage chamber of sampling element is accommodated, described storage chamber includes opening, side wall and bottom Portion；Detection means includes detection means, and the device includes the host cavity and test chamber for accommodating collection device, wherein, the receiving is received The chamber of acquisition means includes side wall and bottom and opening；

Wherein, accommodating the storage chamber of sampling element includes the second breakable element, and the bottom of accommodating chamber punctures member including second Part；

Collection device is inserted into the accommodating chamber of detection means, allows the second puncturing elements to correspond to the second breakable element；

Second lid is covered the opening of host cavity, promote collection device to be moved in host cavity, so as to allow the second thorn Broken element punctures the second breakable element.

In some preferable modes, the second lid element for covering accommodating chamber opening includes the first puncturing elements, Include the first breakable element on first lid of collection device.Second lid is covered the opening of host cavity, positioned at the second lid The second puncturing elements on body puncture the first breakable element.

In some embodiments, sample is obtained with sampling element, then sampling element is inserted into storage chamber. In some specific modes, sampling element and the first lid element are the structure that is connected as a single entity.

In the technical scheme of above method, before some of the structure of any structure and check device on collection device The embodiment stated can be applied in method and technology scheme.

Beneficial effect

It can be used for collecting or detecting blood, urine, saliva and fecal sample using collection device of the present utility model, receive It is similar to collect sample mode, it is not error-prone.The detection means can be used for the detection of combination product, can at most there is 9 kinds of different reagents Bar is used for the detection of same sample, and mode of operation is unified.Once-through operation can be completed more than most 9 products or 9 products Detection, reduce workload, improve operating efficiency.In addition, after collection device collects sample, whole collection device is inserted into inspection Survey in device and detected, do not allow collection device and detection means to separate, preserve, decreased in addition to environment so as to convenient Pollution, in addition when needing to trace testing result or detection process, detection means and collection device are integrated, convenient Retrospect.Another advantage is that collection and detection separate, and when any need detects, is inserted into detection means and is examined Survey, operation facility.

Brief description of the drawings

Figure 1A is the structural representation of collection device of the present utility model.

Figure 1B is the structural representation after being inserted into the storage chamber in collection device after sampling element obtains sample.

Fig. 2 is the structural representation of detection means.

Fig. 3 is the positive structure schematic of detection means.

Fig. 4 is the structural representation of the collection device in an embodiment.

Fig. 5 is the structural representation of the sampling element in an embodiment.

Fig. 6 A are the dimensional structure diagram of the second lid.

Fig. 6 B are the sectional view of the second lid.

Fig. 7 A- Fig. 7 D are collection device and detection means operating process schematic diagram.

Fig. 8 A- Fig. 8 D are the structural representation of various forms of sampling elements.

Embodiment

The structure that the utility model is related to or these used technical terms are described further below, these are said Bright is not further to limit of the present utility model, but explains how to realize according to marrow of the present utility model.

Detection

Detection represents to chemically examine or test a kind of material or material whether there is, such as, but this is not limited to, chemical substance, The generation of organic compound, inorganic compound, metabolism product, medicine or drug metabolite, organic organization or organic organization Thank thing, nucleic acid, protein or polymer.In addition, detection represents test substances or the quantity of material.Furtherly, table is gone back in chemical examination Show immune detection, chemical detection, enzyme detection etc..

Sample

The sample of what type can be tested with device of the present utility model, including body fluid is (for example, urine and other Body fluid, and clinical sample).Liquid sample may originate from solid or semisolid sample, including excrement, biological tissue and food Thing sample.These solids and semisolid sample can be transformed into liquid sample by any suitable method, such as one Mixed in kind appropriate liquid, stamp broken, macerated, be incubated, dissolving or enzymolysis solid sample (for example, water, phosphate buffer or The other buffer solutions of person)." biological specimen " includes the sample from animal living, plant and food, also including urine, saliva, blood Liquid and blood constituent, cerebrospinal fluid, vaginal swab, seminal fluid, excrement, sweat, secretion, tissue, organ, tumour, tissue and organ Culture, it is the conditioned media of cell culture and there, either people or animal.Food sample includes finished Food ingredients and last product, meat, cheese, wine, milk and drinking water.Plant sample is included from any plant, plant group Knit, the sample of the conditioned media of plant cell cultures and there." environmental samples " be those be derived from environment sample (for example, The sample of lake water sample or other water bodys, sewage sample, soil sample, underground water sample, Seawater Samples, the sample of runoff water This).Sewage and related waste can also be included in environmental samples.

Testing element 42

Testing element can select the test strip of lateral flow, and it can detect a variety of analytes.Certainly, other are closed Suitable testing element can also be used in the utility model.

Various testing elements can be grouped together and apply in the utility model.A kind of form is Test paper.With In the Test paper for analyzing the analyte (such as drugs or show the metabolin of health) in sample can be various forms, Such as immunoassays or the form of chemical analysis.Test paper can use the analytical model of non-competing method or competition law.Detection examination Paper bag is containing an absorbent material with sample application zone, reagent area and test section.Sample-adding passes through capillary originally to sample application zone Effect flows to reagent area.In reagent area, if there is analyte, sample is combined with reagent.Then sample continues to flow to inspection Survey area.Other reagents, such as molecule with the Non-specific combination of analyte are fixed on detection zone.In these reagents and sample Analyte (if present) is reacted and analyte is incorporated in into the area, or is combined with some reagent of reagent area.With Exist and reagent area or the mark zone separated in the label of display detection signal.

Typical non-competing method analytical model is that signal will produce if containing analyte in sample, if do not wrapped Containing analyte, signal is not just produced.In competition law, if analyte is not present in sample, signal produces, if deposited In analyte, then signal is not produced.

Testing element is Test paper, can select water suction or the material not absorbed water.Test paper may include multiple material For liquid sample transmission.The material of one of which Test paper can cover on another material, as filter paper is covered in nitric acid On cellulose membrane.One area of Test paper can select one or more materials, and another area selects other different one kind Or multiple material.Test paper can be attached on certain holder or hard surface is used for raising and is affectedly bashful the strong of Test paper Degree.

Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction Kind or a variety of enzymes, using such as foregoing method being fixed on specific combinating substance on Test paper, one or more signals are sent out The composition of raw system is fixed on the analyte detection zone of Test paper.Produce signal material can in sample application zone, reagent area, Or on detection zone, or whole Test paper, the material can be full of on one or more materials of Test paper.Signal will be contained The solution of thing is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the thing containing signal.Contain addition The test paper of signal thing solution is dried.

Each area of Test paper can arrange in the following manner：Sample application zone, reagent area, detection zone, control zone, determine sample This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of On one test paper of material.It may also be not same district and use different materials.Each area directly can contact with liquid sample, or not Direction arrangement of the same area according to liquid sample flowing, the end in each area is connected and overlapped with the front end in another area.Used Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it His form.

Typically conventional reagent strip is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre Specific binding molecule is fixed on acid cellulose film to show the result of detection；It can also be cellulose acetate film or nylon membrane etc. Deng.Such as reagent strip or the device containing reagent strip of the following patent description：US 4857453；US 5073484；US 5119831；US 5185127；US 5275785； US 5416000；US 5504013；US 5602040；US 5622871；US 5654162；US 5656503；US 5686315；US 5766961；US 5770460；US 5916815；US 5976895； US 6248598；US 6140136；US 6187269；US 6187598；US 6228660；US 6235241；US 6306642；US 6352862；US 6372515；US 6379620；With US 6403383.Test-strips disclosed in patent documents above and carry The similar device of test-strips, which can be applied in testing element of the present utility model or detection means, carries out analyte The detection of matter, for example, in sample by point about material detection.

Above testing element can be arranged in the test chamber of detection means to be contacted with liquid sample.Preferably, with The sample applying zone of the testing element of liquid sample contact, such as on fiberglass packing.In some specific modes, test Element can be located in the groove 44 of test chamber to carry out the test of liquid sample.

Analyte

Any analyte can be analyzed with the utility model.The analyte of the utility model stable detection can be used Example include (but not only including) human chorionic gonadotrophin (hCG), lutropin (LH), ovarian stimulation element (FSH) medicine of, hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B surface antigen, AIDS virus and any abuse.Quilt Analyte can detect in any liquid or liquefaction sample, such as urine, saliva, saliva, blood, blood plasma, or Serum.The example of other analytes also has flesh ammonia acid anhydride acid, bilirubin, nitrite, protein (nonspecific), blood Liquid, leucocyte, blood glucose, heavy metal and toxin, bacterial component (for example, the special protein and sugar of certain types of bacterium, Such as colon bacillus 0157:H7, staphylococcus aureus, salmonella, C.perfringens, campylobacter, monokaryon hyperplasia Lee This special bacterium, V. parahaemolyticus, or wax bacillus).The analyte of any other suitable lateral flow test format can Detected with the present apparatus.Analyte, which can also be, to be infectious material or can prompt the material of infection period.Analyte can be Medicine (such as drug abuse), hormone, albumen, nucleic acid molecules, pathogen.The analyte being related in the utility model can be used Example includes some haptens materials, and these haptens include drugs (such as drug abuse)." drug abuse " (DOA) refers to non-doctor Learn destination and use medicine (generally playing paralysis nerve).Abusing these medicines can cause body ＆ mind to suffer damage, Produce dependence, addicted and/or dead.The example of drug abuse includes cocaine；Amphetamine AMP is (for example, black U.S. People, white amphetamine tablet, dextroamphetamine, dexie, Beans)；Crystal methamphetamine MET (crank, Meth, crystal, speed)；Barbiturate BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (paramedicines of sleeping)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, Goofballs, barbs, blue devils, yellow jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e., third Miaow piperazine, amitriptyline and doxepin)；Diformazan methylenedioxymethamphetamine aniline MDMA；Hog (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine MOP or, opium, cocaine COC；, heroin, hydroxyl Dihydrocodeinone)；Anxiolytic and hypnotic sedative agent, anxiolytic are that one kind is mainly used in anxiety reduction, anxiety, fear, Set the mind at rest, have the medicine of hypnosis sedation, including Benzodiazepines BZO (benzodiazepines), atypia BZ concurrently Class, fusion phenodiazine NB23C classes, benzene nitrogen Zhuo class, the part class of BZ acceptors, open loop BZ classes, diphenylmethane derivatives, piperazine carboxylic acid Salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole, other heterocyclics, imidazole type calmness/anodyne are (such as Hydroxyl dihydrocodeinone OXY, methadone MTD), propanediol derivative-carbamates, aliphatic compound, anthracene derivative Deng.Using detection means of the present utility model can be used for detection belong to medical usage but easily overdose detection, Such as tricyclic antidepressant (imipramine or the like) and Paracetamol.These medicines can resolve into not after being absorbed by the body Same small-molecule substance, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or part body fluid is present Above-mentioned small-molecule substance.

Collection device

If it is a specific embodiment of receiving apparatus for example, shown in Figure 1A, the collection device 200 includes sampling Element, the sampling element include the first lid 10 and sampling head 13, wherein, the lid 10 of sampling head 13 and first is connected as a single entity knot Structure.In preferable mode, the lid 10 of sampling head 13 and first is connected as a single entity structure by a bar 11, so, when sampling Wait, directly can hold absorption or sampling that lid carries out sample by hand.After the sample of needs is taken, storage is inserted into Stored in chamber 21, transported or be transplanted on and formulate the detection (shown in Figure 1B) that place carries out analyte, also may be used certainly To be detected after sampling at once.

In some specific modes, for different samples, different sampling heads can be designed.When sampling head is absorption When the material composition of liquid, liquid sample can be absorbed, when sampling head is not liquid material, but other structures When design, the sample of solid-state or pipe solid-state can be taken.Connecting rod 11 can link together with sampling head, meanwhile, even Extension bar can be connected as a single entity structure with lid.This be connected as a single entity structure can be non-removable structure, such as sampling head 13 link together inseparable or can separate with connecting rod 11.Connecting rod and the connection of the first lid 10 It can be dismountable or non-removable, preferably dismountable relation.So, the sampling of connecting rod connection Head can be designed for different samples, then using the first lid of same structure, so as to for different Sampling requirement is arbitrarily combined.Such as the sampling head that Fig. 8 A- Fig. 8 D are several different designs, these sampling heads and connecting rod Be connected as a single entity structure, and different gathering elements then can be formed with cover assembling.For example, in Figure 1A, 13 main pin of sampling head Liquid sample is carried out, such as saliva sample, for the gathering element of saliva, the very strong spongy top of sampling head absorption affinity, from And saliva sample is directly drawn from mouth.Such as Fig. 8 B- Fig. 8 C take solid sample and designed, such as sampling head 131 is spoon Shape, it is mainly used in the sampler of stool (a large amount of), top is the small spoon of ellipse, can use more amount excrement.Fig. 8 C sampling head To be bar-shaped, there are helicla flute or annular groove, hole, hole or other sunk structures 132 above, so when taking solid-state or semisolid Sample when, sampling head is inserted into solid-state or semisolid sample, so as to allow sample to fill these sunk structures, from And obtain sample.Such sampling element is mainly used in the sampler of stool (a small amount of), and top is helical form plastics spillikin, is taken Sample amount is not a lot.Such as shown in Fig. 8 D, sampling head is a pipe shape structure 133, the tubular structure can be compressible suction Liquid pipe or the capillary with capillary force, such sampling head are mainly used in absorbing urine or blood sample 's.

The different sampling head of the above can be connected as a single entity structure with connecting rod 11, and connecting rod 11 can be torn open with the first lid The mode unloaded connects, and when needing to be directed to different samples, the sampling head can of fit on different structure designs is convenient It is sampled.

In some preferable modes, collection device includes storage chamber 21, and the storage chamber includes side wall and bottom and opened Mouth is formed, and the storage chamber is used for housing sampling element and being stored.In some preferable modes, storage chamber includes processing sample This reagent, such as the solid state reagents of solution reagent or non-solution, these reagents are primarily used to the sample progress to collection Processing, for example, elute, buffer, dissolving, the analyte for non-purpose of degrading, discharge impurity, precipitation etc. act on.The reagent can be with It by the state presence of solution can also be dry reagent (such as in the form of powder, granule etc.) to be.When the sample of collection be it is dry or When person's solid-state, semisolid, the reagent for handling sample can be existed as a solution, and so these are not solution states Sample can be dissolved or suspend in the solution, which analyte be just dissolved in processing sample reagent solution in. When the sample of collection is liquid, the reagent that handles sample can be dry state, such as powder, particle, particulate, tablet Form, such liquid sample with regard to dissolution process sample dry reagent, so as to reach the processing to sample.

In some modes, the bottom of storage chamber 21 includes the first breakable element, and the breakable element is easily punctured element Puncture, so as to allow storage chamber that there is opening, so that the reagent treatment positioned at the liquid sample of storage chamber or containing sample is molten Liquid stream goes out, so as to carry out the chemical examination of analyte or detection (shown in Fig. 6).In some preferable modes, sampling element The first lid on include the second breakable element, the element can be punctured element and puncture, in a preferable mode, first Dare bag and include a passage 18, the passage end is sealed by the second breakable element, and the other end of the passage can be with connecting rod 11 Connection directly communicates (Fig. 5) with ambient atmosphere.When sampling element has removed liquid sample, sampling element is directly inserted Enter and preserved or transported into storage chamber 21.The opening of the sealed storage chamber of the first lid 10 of sampling element, due to now Although whole collection device includes breakable element, such as the first breakable element that can include positioned at storage chamber bottom is located at Second breakable element of lid, is not all punctured now.Protected so as to allow the sample for carrying sampling head to be located in storage chamber Deposit, transport or carry out detection immediately, can be discussed in detail how to be detected below.So, the sample of collection device is not just Environment can be leaked to be revealed.

Detection means

Another aspect of the present utility model, there is provided detection means 300, the detection means include housing collection device 200 Host cavity 32, and for puncturing the first puncturing elements 33 of the first breakable element.In some preferred embodiments, house Chamber 32 includes side wall, opening and bottom.The first described puncturing elements 33 are located at the bottom of host cavity 32.In some preferable sides In formula, it is that different materials is formed to form the side wall of host cavity and bottom, and then host cavity is Nian Jie with bottom or is welded. Include the first puncturing elements on bottom to puncture the first breakable element.In some modes, detection means also includes test chamber 41, testing element 42 is included in test chamber.Wherein test chamber is formed with host cavity and is in fluid communication.In a preferable example In, the bottom of test chamber has the bottom that opening leads to host cavity, so as to which the liquid in host cavity can flow to the bottom of test chamber, So as to contact the testing element in test chamber.

In some preferable modes, test chamber includes the groove of multiple receiving testing elements, and such groove 44 can be one Individual or multiple, each test-strips can be directed to different analytes, or several different analytes.Such as 1-10 groove can be opened, each groove can accommodate a testing element (reagent strip), so as to enter for same sample The detection of the different analytes of row (shown in Fig. 3).Include detection card, detection card in a preferable mode, in test chamber In include one or more testing elements.

In some preferable modes, detection means also includes the second lid 31 of an opening for covering host cavity 32, Second lid is used for sealing the opening of host cavity, so as to seal host cavity.Preferably, host cavity can house lower whole completely Collection device 200, so as to allow collection device to be maintained in host cavity 32.Preferably, the second lid includes the second puncturing elements 301 (shown in Fig. 6 A-6B)

The collection and detection of sample how are carried out with reference to specific embodiment.Such as the collection shown in Fig. 7 And detection process.For example, being collected (Fig. 7 A) to sample using collection device 200, then whole collection device 200 is placed In the host cavity 32 of detection means (Fig. 7 B), the second lid 31 in detection means is then covered, with the conjunction of lid, is compeled Change position of the collection device in host cavity, so as to allow the first puncturing elements to puncture the first breakable element, so as to make way for The liquid (can be liquid sample or the sample containing reagent treatment) of storage chamber 21 exits into from storage chamber 21 Into host cavity 32, meanwhile, flow in test chamber 41 positioned at the liquid of host cavity and contacted with the testing element in test chamber, So as to complete to detect.

Certainly, collection device might not need to detect at once after collecting, but stored or transported in detection The heart, wait when suitable opportunity needing to be detected, just detected, carried out according to above-mentioned method.

In some preferable modes, more detailed elaboration collection and detection process are carried out with reference to specific example.Example Such as, if the sample being directed to is saliva, gathering element (Fig. 8 A) is put into the mouth of sample gatherer, until the spongy top in mouth 13 soften, and spongy top is taken out, is put into the storage chamber 13 of collection device 200, when rotating the first lid, spongy top is interior Tube wall extrudes, saliva outflow.Or the solution reagent for having processing sample in advance in storage chamber 13 is rinsed to spongy top, carried Take or dissolve.This when, the saliva sample of collection are stored in collection device, although the storage chamber of collection device Bottom includes breakable element, but this when also not than puncturing, can be independent it is transported, carry, storage etc..For example, For collecting fecal sample：The spoon of gathering element is dug into a certain amount of fecal sample (Fig. 8 B) or chosen into a certain amount of excrement Sample (Fig. 8 C), is put into the storage chamber 21 for being already equipped with lysate, after mixing.Collection device 200 is put into detection means In host cavity, after covering the first lid, sample is escaped in the test chamber of detection means, the detection (Fig. 7) for different product. For example, for collecting urine specimen：Gathering element is sucked into a certain amount of urine specimen, dress is collected according to above-mentioned method The combination put and being placed into detection means is detected (Fig. 8 D).

When needing to be detected, whole collection device is inserted into the host cavity 32 of detection means (Fig. 7 B), It is this when, corresponding positioned at the first breakable element of the bottom of storage chamber 21 and the first puncturing elements of host cavity, but be in order at The state that will be punctured, this when, whole collection device somewhat expose outside host cavity opening, and this is covered second in time The body conjunction is in the opening of host cavity, and with covering for lid, lid moves downward, so as to promote whole collection device housing Moved in chamber, so as to force the first puncturing elements 33 to puncture the first breakable element 22, so as to discharge the liquid for being located at storage chamber Into host cavity 32 (such as Fig. 7 C).So as to which the liquid of host cavity is flowed in test chamber 41, is connect with the testing element 42 in test chamber Touch, so as to obtain the quantity of analyte or existing quantity.Such as Fig. 7 D, can by transparent test chamber with the naked eye come Go to read the test result on testing element, can also can also be put into reading equipment directly with scanned copy come scanning detecting result In test result on automatic read test element.

In some preferable modes, in order to it is more preferable, easier allow collection device moved in host cavity (on Lower motion or rotary motion), so as to allow the first puncturing elements easily to puncture the first breakable element, in the first lid of collection device Also include the second breakable element 14 (Fig. 5) on body, (the figure of the second puncturing elements 301 is included on the first lid of detection means 6B).When whole collection device is implanted in host cavity 32, and the opening of host cavity is covered with the second lid, the second thorn Broken element punctures the second breakable element, while the first puncturing elements are located in the first lid (with collection head in collection device), So, the motion of the second lid, collection device is allowed to be in a relatively steady state, so as to allow the first puncturing elements pair Standard is directed at the first breakable element all the time, so as to more easily puncture the first breakable element.Because general first is frangible The area of element is smaller with the contact surface of the first puncturing elements, if promoting whole collection device receiving in the second lid During cavity volume moves, if position double swerve of the collection device in host cavity or waved, the first puncturing elements can Can not be contacted with breakable element but touch non frangible element and (touch the upper of non frangible element, can not sometimes puncture Storage chamber), the motion of the very big strength promotion collection device is so needed, opposite it is also possible to which the first lancing device can not allow Easily, low-force gas punctures the first breakable element, so as to increase the difficulty of operation, reduces the comfortableness of operation.At one In preferable mode, in order to allow the first puncturing elements preferably to control position of the collection device in host cavity, allow second frangible Pipeline 18 in the lid of component seal first, when the first puncturing elements puncture the second breakable element, puncturing elements are located at In pipeline 18, so as to more easily consolidate position of the collection device in host cavity.Because collection device receives sample After need to be inserted when whole collection device come sealed storage chamber 21, at least liquid-tight envelope or/and person's hermetic seal with the first lid 10 Enter into host cavity, if after the first puncturing elements have punctured the first breakable element, it is easy to puncture second using the second puncturing elements After broken element, in the moment punctured, the opening of lid and blow-by host cavity, this when, storage chamber 21 enters promoting the circulation of qi with the external world Body flows, and particularly as being to be circulated by the pipeline 18 of the first lid with extraneous, while to puncture first frangible for the first puncturing elements 33 Element 22, now, due to host cavity and storage chamber flow communication, all with ambient atmosphere (outside environment of host cavity) identical, liquid Body is analyzed because the gravity of oneself can be flowed into host cavity along the first puncturing elements so as to be flowed into test chamber The chemical examination of material.

In some preferable modes, the chamber for accommodating collection device punctures member including puncturing the first of the first breakable element Part.Preferably, the first puncturing elements are positioned at the bottom for the chamber for accommodating collection device.In some preferable modes, the second lid Including the second puncturing elements for puncturing the first lid breakable element.In some preferable modes, first and second is frangible Element is the element being easily broken or the element being easily punctured, these breakable elements can be film, glass, adhesive sticker, Plastic film, plastic tab etc..Corresponding, the first puncturing elements and the second puncturing elements are with respect to the first and second breakable elements Sample rigidity is strong or sharp, is so easier puncturing, smashing, piercing through the first and second breakable elements.It is such to be arranged on Those of ordinary skill in the art easily realize that concrete mode has a variety of selections.Such as making the easy of collection device When broken element, an aperture can be opened in storage chamber bottom now, thin film is then covered on aperture；Adhesive sticker etc., this The puncturing elements of sample first can be pin, sharp structure, easily puncture the first breakable element.In optional mode, disposable When the storage chamber of injection molding, a plastic tab is additionally formed in the bottom of chamber, plastic tab connection storage chamber Bottom, thickness are 1-2 millimeters, and when the thin slice, by the first puncturing elements positioned at host cavity bottom, (rigid plastic is formed sharp The structure of shape) easily puncture the thin slice.Preferably, when the storage chamber of once injection moulding, have in the bottom of chamber There is the position of depression, a plastic tab (Fig. 7 B or Fig. 4) is formed in the position of depression, so when the first puncturing elements corresponding the When one breakable element, when not punctured also, the part of the first puncturing elements is located in recessed position, from And more accurate corresponding first breakable element, so as to make operation more simple, easy.

Same reason, the second breakable element and the second puncturing elements can also be configured in a manner mentioned above, example The first breakable element is such as allowed to seal the pipeline in the first lid, after the first puncturing elements puncture breakable element, second punctures member Part is located in pipeline.

All patents and publication mentioned in the utility model specification all represent that these are the public technologies of this area, The utility model can use.All patents referred to herein and publication are all equally listed in bibliography, with each Individual publication is specifically individually referenced the same.The utility model described here can lack any element or Multiple element, realized in the case of one kind limitation or a variety of limitations, this limitation here is not particularly illustrated.It is such as each here Term "comprising" in individual example, " essence by ... form " and " by ... form " remaining 2 term of one of both can be used Instead of.Here describing mode carried out by the term and expression way used, and be not limited except as, also refer to here without any intention These terms of bright this book description and explanation eliminate any equivalent feature, but it is recognised that can be in the utility model Any suitably it is altered or modified with being done in the range of claim.It is appreciated that the examples of implementation described by the utility model All it is that some preferred embodiments and feature, any those of ordinary skill in the art can describe according to the utility model Marrow under do some change and change, these change and change be recognized as belonging to the scope of the utility model and independent right It is required that and in the range of appended claims limit.

Claims

1. a kind of sample collection device, it is characterised in that the collection device includes：Sampling element, and be linked as with sampling element The lid element of one；With the storage chamber for accommodating sampling element, described storage chamber surrounds including opening, side wall and bottom；Institute The storage chamber bottom stated includes the first breakable element；The breakable element can be punctured element and puncture.

2. sample collection device according to claim 1, it is characterised in that also include second frangible yuan on described lid Part, the breakable element can be punctured element and puncture.

3. sample collection device according to claim 1, it is characterised in that described lid is opened for sealed storage chamber The lid of mouth.

4. sample collection device according to claim 1, it is characterised in that described sampling element is water adsorbent element.

5. sample collection device according to claim 1, it is characterised in that described sampling element is spoon shape element, inhaled Manage or with reeded element.

6. sample collection device according to claim 4, it is characterised in that described water adsorbent element is sponge material.

7. sample collection device according to claim 1, it is characterised in that described sampling element and lid passes through connection Bar is connected as a single entity.

8. sample collection device according to claim 1, it is characterised in that done in described storage chamber including sample process Reagent or sample process solution.

9. sample collection device according to claim 1, it is characterised in that sampling element and lid element are with dismountable Mode connects.

10. sample collection device according to claim 2, it is characterised in that also include a pipeline on described lid, One end of pipeline is sealed by the second breakable element.