CN201043969Y - Biological liquid sample testing apparatus - Google Patents
Biological liquid sample testing apparatus Download PDFInfo
- Publication number
- CN201043969Y CN201043969Y CNU2007201093511U CN200720109351U CN201043969Y CN 201043969 Y CN201043969 Y CN 201043969Y CN U2007201093511 U CNU2007201093511 U CN U2007201093511U CN 200720109351 U CN200720109351 U CN 200720109351U CN 201043969 Y CN201043969 Y CN 201043969Y
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- sampler
- liquid sample
- chamber
- unit
- liquid
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Abstract
The utility model relates to a detecting device of biological liquid sample, which comprises a collected liquid cavity and a reagent strip cavity. The liquid cavity is composed of a reagent strip that test weather analyzed substance exists in the tested liquid sample. Besides, the detection device also includes a sampling device, through which liquid sample in the collected liquid cavity can be absorbed. In this way, when preliminary test result is doubted, the whole detecting device has no need to be sent to the testing center to do further chemical examination, reducing transportation cost. In addition, the operator of further chemical examination can get samples from the sampling device without opening the sealing cover on the liquid cavity, making the test safer and more reliable.
Description
Technical field
The utility model relates to a kind of analysis and detection device of biological specimen.
Background technology
At present, judge tentatively with whether containing certain interested drugs micromolecule in the urine cup device detection urine that contains reagent strip whether tested person person exists drug abuse.U.S. Pat 66576193 disclosed a kind of pick-up units for example, this pick-up unit comprises a liquid cavity and a cavity of accommodating test-strips of accommodating liquid sample, the cavity of accommodating liquid and the cavity of accommodating test-strips and piston that have aperture rotary by links to each other, work as liquid, urine for example, after being housed in the host cavity, can rotating piston, allow a part of liquid of host cavity flow to by aperture in the chamber of accommodating reagent strip with reagent strip on chemical reaction, and tentatively draw testing result.Of this sort pick-up unit also has announcement at U.S. Patent Application Publication US2004/0132091A1 and US20040133128A1.But, detecting the result who draws by these pick-up units only is preliminary result, and can not be final testing result, when to testing result the time with suspicion, pick-up unit usually will be sent to the inspection center and do further detection, and is for example with gas phase or liquid phase look general, perhaps other detecting instruments, detect and confirm whether really include interested material in the liquid sample in the host cavity, for example the drug abuse micromolecule.
But, there is following defective in these pick-up units of the prior art: when doing further detection, usually to deliver to whole detection device by mailing or other modes the inspection center of appointment, like this because the volume of pick-up unit is big, quality is big, often cause the raising of transportation cost expense, moreover, include liquid sample in the pick-up unit, may may the liquid of the inside be polluted owing to pick-up unit self reason or long-distance transportation reason, the result of further chemical examination can be affected, and, because the volume of liquid sample is all very big, may cause the omission of liquid sample.In addition, when this pick-up unit is received by inspection center, need open the cavity of collecting liquid and take a sample, may cause the pollution of sample like this, and seem dangerous human body or environment.
Summary of the invention
The utility model will solve the shortcoming of above-mentioned prior art, and a kind of sampler is provided, and an end and the fluid storage chamber of this sampler communicate, and the other end by this sampler can take out the liquid in the host cavity.When the time with suspicion, can directly getting a certain amount of tracer liquid, be sent to inspection center then and further chemically examine detection like this by sampler to the Preliminary detection result.In addition, when whole detection device is received by inspection center, do not need to open host cavity and collect sample, chemically examine detection but directly collect a certain amount of sample by sampler.
The utility model solves the technical scheme that its technical matters adopts: this biological liquid sample pick-up unit, comprise the liquid cavity and the reagent strip cavity of accommodating tracer liquid, comprise in the reagent strip chamber that can carry out Preliminary detection to the liquid in the collecting chamber sees the reagent strip that whether contains analyte in the liquid sample, also comprises the sampler that an end is identical with fluid chamber in pick-up unit.
The utility model can be further perfect by following manner:
Sampler can be to be positioned on the lid of host cavity, and sampler is made for the plastics or the elastomeric material that are punctured easily, when whole detection device is received by inspection center, can directly use syringe sampling.For example do into one one chemical examination with the syringe needle detection sample that the sampler of elastomeric material directly takes out certain volume that punctured.
In addition, sampler is that a tubular structure is positioned on the lid of host cavity, this tubular structure one end and fluid chamber communicate, the other end communicates with atmosphere, after preliminary detection finishes, think when being necessary to do further detection, end with vacuum tube is pressed to the end thorn that tubular structure communicates with atmosphere, tubular structure just pierces through vacuum tube like this, reason owing to draught head, the tracer liquid of the fluid chamber in the pick-up unit just is collected in the vacuum tube by sampler automatically, so just can directly deliver to inspection center to vacuum tube and do further chemical examination.In addition, if after pick-up unit is received by inspection center, also can directly will make the sample of further chemical examination, and the lid that does not need to open fluid chamber is collected the detection sample of the automatic collection of vacuum tube.In the embodiment of an optimization, the sampler of tubular structure is the close property of a liquid structure, concretely, when tubular structure communicates with atmosphere, tracer liquid in the fluid chamber can not flow out from tubular structure, but when being inserted into vacuum tube, because draught head, can allow the tracer liquid in the fluid chamber flow in the vacuum tube by tubular structure.
In another preferred scheme, the sampler of above-mentioned tubulose is positioned in the fluid chamber, and an end of tubular structure communicates with fluid chamber, and the other end communicates with atmosphere.In a concrete mode, an end that communicates with atmosphere is equipped with protective sleeve.Because an end that communicates with atmosphere is sharper, the purpose that protective sleeve is housed is the injury that prevents when not using sampler the operator.Like this, when needs are drawn sample with vacuum tube, take down the protective sleeve sampling, refill protective sleeve after sampling finishes.Another preferred embodiment in, in pick-up unit, also comprise the cavity of accommodating sampler, one end in this chamber communicates with the tracer liquid fluid chamber by an end of this tubular structure, the other end in this chamber is that cavity hatch communicates with atmosphere, and the size of cavity hatch is big or small consistent with vacuum tube, like this, vacuum tube is easy to insert in the cavity of accommodating sampler and by the other end of tubular structure and pierces through.Operation safe and convenient like this.
The effect that the utility model is useful is: after pick-up unit comprises sampler, can directly get a certain amount of sample by sampler and do further chemical examination, and not need whole detection device is sent to inspection center, save cost like this.In addition, after pick-up unit comprised sampler, when whole detection device was received by inspection center, the lid that does not need to open on the fluid chamber was drawn the detection sample, and only need draw an amount of sample automatically by sampler does further detection.Safe and reliable like this, can not cause pollution to personnel and environment.
Description of drawings
Fig. 1 is the utility model handstand perspective view;
Fig. 2 is the perspective view in the utility model embodiment 1 front;
Fig. 3 is the utility model embodiment 1 cross-sectional view;
Fig. 4 is the utility model embodiment 1 operation steps one: the cross-sectional view that liquid sample is poured into fluid chamber;
Fig. 5 is the utility model embodiment 1 operation steps two: cover these cross-sectional view to be detected of cup;
Fig. 6 is the utility model embodiment 1 operation steps three: after detecting end by the time, and the cross-sectional view of being inverted pick-up unit;
Fig. 7 is the utility model embodiment 1 operation steps four: vacuum tube is inserted in the cavity of accommodating sampler, by the cross-sectional view of the liquid sample in the automatic liquid draw body cavity of sampler;
Fig. 8 is the utility model embodiment 1 operation steps five: after having got liquid sample, cover the cross-sectional view of cap stopper;
Description of reference numerals: detect urine cup 1, the cup 5 of liquid sample, bowl cover 6 are accommodated in reagent strip chamber 2, accommodate the cavity 4 of piston, piston 8, key bolt 7 is accommodated the fluid chamber 53 of tracer liquid, accommodate the chamber 9 of sampler, sampler 10, connecting pipe 17, conduit 13, shank 10, syringe needle 11, cap 15, cap stopper 3, vacuum tube 45, keyhole 35, passage 16, cup liquid level 51 just immediately, the liquid level 52 when cup stands upside down
Embodiment
Below in conjunction with concrete accompanying drawing examples of implementation of the present utility model are described in detail.These specific embodiment only are limited the enumerating under the utility model spirit, do not get rid of one of ordinary skill in the art prior art and the utility model in conjunction with and other specific embodiments of producing.
Embodiment 1: as Figure 1-3, pick-up unit is a urine cup 1, it comprises cup 5, the bowl cover 6 of accommodating tracer liquid and accommodates the cavity 2 of reagent strip and accommodate the cavity 4 of piston, in cavity 4 sealing install one can movable piston 8, when tracer liquid is equipped with in the cup chamber 53 of accommodating tracer liquid,, the obstruct of piston 8 carries out detection reaction because can not flowing in the cavity 2 of accommodating reagent strip liquid by piston.When needs detect, operated piston, for example rotating piston or pushing piston, make tracer liquid by piston and passage 16 flow in the cavity 2 with reagent strip on the chemical reagent of band react and tentatively draw testing result.The concrete structure of these urine cups all has detailed description in U.S. Pat 66576193 and U.S. publication application US2004/0132091A1 and US20040133128A, be not emphasis of the present utility model.In addition, also comprise a cavity 9 of accommodating sampler 10 in the chamber of tracer liquid accommodating, cavity 9 one end openings maintain an equal level at the bottom of cup and with the bottom of cup, at ordinary times by a cap stopper 3 sealings; The other end of cavity 9 is arranged in the fluid chamber 53 of cavity 5, and sampler comprises a connecting pipe 17, communicates with fluid chamber 53 by the connecting pipe 17 that is installed in cavity bottom, and an end of connecting pipe 17 extend in the chamber 53, and the other end is arranged in chamber 9.The bottom in connecting pipe 17 and chamber 9 also can be to be connected as a single entity by once injection moulding for being tightly connected, and can only allow like this tracer liquid flows to outside the pick-up unit by connecting pipe 17 in the fluid chamber 53.An end that extend in the chamber 53 at connecting pipe 17 can also connect a conduit 13, and conduit 13 like this, when collecting the detection sample in chamber 53 when, can avoid liquid to flow in connecting pipe near the cup wall.In addition, connect a pin at an end of the connecting pipe that is arranged in chamber 9, syringe needle 11 can be installed a pin and emit 15, and needle tip is positioned within the whole chamber 9, so relatively safety.
Implement 1 concrete operating process below in conjunction with description of drawings.
Step 1 shown in Figure 4 is opened urine cup bowl cover 6, contains the tracer liquid of certain volume in the chamber 53 of accommodating tracer liquid.
Step 2 shown in Figure 5 is covered tight lid 6, starts pistons 8 with key bolt 7, liquid in the fluid chamber is flow to by piston in the chamber of accommodating reagent strip and reacts to detect whether there is interested material in the sample with chemical reagent on the reagent strip.Then key bolt 7 is put back in the keyhole 35.After question response finishes, observe the testing result on the reagent strip.Liquid level position is shown among the figure 51.
Step 4 shown in Figure 7, take off block 3, the direction of vacuum tube 45 along the arrow indication is inserted in the chamber 9, the syringe needle 12 that is arranged in chamber 9 pierces through plastics or the rubber on the vacuum tube, owing to the difference of air pressure, can collect the tracer liquid of certain volume in the vacuum tube automatically.Then vacuum tube 45 is posted or directly delivered to inspection center and make a definite diagnosis chemical examination.
Step 5 shown in Figure 7 seals up cap 3 opening in chamber 9 at last along the direction of arrow.
Embodiment 2: as different from Example 1, accommodate 53 li chambeies 9 of not accommodating sampler, chamber of detecting sample, in chamber 9, there is not sampler yet, and sampler 10 directly is installed on the bowl cover 6, the keyhole 35 of placing key bolt 7 is as the chamber of accommodating sampler, and sampler is identical with position and the array mode of sampler in chamber 9 in the enforcement 1 in the position and the array mode of keyhole 35.And key bolt 7 replaces cap stopper 3 to protect syringe needle 12.The mode of a comparison just is mounted in that conduit 13 on the connecting pipe is located immediately at the bottom in chamber 53 or near the bottom.Operation time, only need from keyhole 35, take out key bolt 7, vacuum tube is inserted in the keyhole 35 goes then, owing to draught head, can sampler directly draw the detection sample of prescribed volume and do further chemical examination.
Embodiment 3: as shown in Figure 7, the utility model also provides a kind of liquid sample detection device, this device system is except comprising 1 or 2 pick-up unit, also comprise vacuum sampling tube 45, this vacuum tube can any volume, comprises 1 milliliter, 5 milliliters, 10 milliliters, 15 milliliters, one of 20 milliliters or 25 milliliters or several.When on utilizing vacuum tube 45 and sampler, being used, authenticity for fear of sampling, face imbitition from the chamber 9 of accommodating liquid that can the person of working as detected person, and write and be sent to the chemical examination center after the necessary information and do further detection whether chemically examine Preliminary detection result for confirmation accurate.
To the structure of pick-up unit, parts or this employed technical term are described further below.
Detect
Detect the expression chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, detect the quantity of expression test substances or material.Furtherly, immune detection, chemical detection, enzyme detection etc. are also represented in chemical examination.
Sample
The sample of the utility model indication refers to that those can be used for detecting, chemically examining or diagnose the material that whether has analyte of interest matter.Sample can be, for example, liquid sample, solid sample and semi-solid sample, liquid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise that solid sample and semi-solid samples are through anticipating the liquid solution that the back forms.Solid sample can comprise ight soil, soil and biosome organ-tissue.The sample of collecting can be used for methods such as immune detection, chemical detection, enzyme detection and detect whether there is analyte.
Reagent strip
Applying to reagent strip of the present utility model can be usually said horizontal effluent reagent strip, and the concrete structure of these reagent strips and detection principle are persons skilled in the art technique known in the prior art.General commonly used reagent strip is the nitrocellulose filter reagent strip, and promptly surveyed area comprises nitrocellulose filter, and fixedly the specific bond molecule shows the result of detection on nitrocellulose filter; Can also be cellulose acetate membrane or nylon membrane or the like.The reagent strip that for example the following patent is described or contain the device of reagent strip: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; With US 6403383, the reagent strip described in these patents can be applied to one or more interested materials of accommodating to come in the reagent strip chamber 2 in the tracer liquid sample.
Analyte
Can analyze any analyte with apparatus and method of the present invention.The example of the analyte of the enough apparatus and method stable detection of the present invention of energy comprises (but not only comprising) human chorionic gonadotrophin (hCG), lutropin (LH), ovarian stimulation element (FSH), hepatitis C virus (HCV), hepatitis B (HBV), hepatitis B surface antigen, the medicine of AIDS virus and any abuse.Analyte can detect in any liquid or liquefied sample, urine for example, saliva, saliva, blood, blood plasma, perhaps serum.The example of other analyte also has the acid of flesh ammonia acid anhydride, cholerythrin, nitrite, protein (nonspecific), blood, leucocyte, blood sugar, heavy metal and toxin, the bacterium composition is (for example, special protein and the sugar of the bacterium of particular type, colon bacillus 0157: H7 for example, staphylococcus aureus, salmonella, C.perfringens, campylobacter, listeria monocytogenes, enteritis vibrios, perhaps cured shape bacillus).Any other analyte of suitable lateral flow assay form can detect with this device.
Analyte can also be some haptens materials, and these haptens comprise drugs (as drug abuse)." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium , RochePharmaceuticals, Nutley, New Jersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.
Urine cup
Solve defective of the prior art except installing the sampler that is disclosed by utility model on the previously described urine cup, in addition, the detection urine cup of other prior aries also can be installed this sampler, and for example the drugs described in U.S.'s publication application US2006/0198758A1 detect urine cup 10 (Fig. 1); Liquid sample described in the utility model patent ZL200420115960.4 of China's bulletin detects cup.Persons skilled in the art are expected the detection urine cup combination with other type easily after reading the utility model.
Claims (9)
1. biological liquid sample pick-up unit, comprise the fluid chamber and the reagent strip chamber of accommodating liquid sample, wherein also comprise in the reagent strip chamber and can detect the reagent strip that whether has analyte from the liquid sample in the fluid chamber, it is characterized in that: on described pick-up unit, also comprise the sampler that an end communicates with described fluid chamber.
2. biological liquid sample pick-up unit as claimed in claim 1 is characterized in that: described sampler is a tubular structure.
3. biological liquid sample pick-up unit as claimed in claim 1 is characterized in that: also comprise the cavity of accommodating sampler in the described fluid chamber, this cavity of accommodating sampler communicates with described fluid chamber by sampler.
4. biological liquid sample pick-up unit as claimed in claim 3 is characterized in that: described sampler comprises and is positioned at the connecting pipe that this accommodates sampler chamber bottom, and this connecting pipe one end is arranged in fluid chamber, and the other end is arranged in the sampler chamber.
5. biological liquid sample pick-up unit as claimed in claim 4 is characterized in that: be connected with syringe needle on the described connecting pipe that is arranged in the sampler chamber, also have a protective sleeve on this syringe needle.
6. biological liquid sample pick-up unit as claimed in claim 1 is characterized in that: described sampler comprises that an end communicates with fluid chamber, the connecting pipe that the other end communicates with atmosphere, and an end of the connecting pipe that communicates with atmosphere is connected with syringe needle.
7. biological liquid sample pick-up unit as claimed in claim 5 is characterized in that: a protective sleeve is arranged on the described syringe needle.
8. biological liquid sample pick-up unit as claimed in claim 1 is characterized in that: this pick-up unit also comprises the vacuum tube by the automatic imbitition sample of described sampler.
9. biological liquid sample pick-up unit as claimed in claim 1 is characterized in that: the volume of described vacuum tube is the 5-25 milliliter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201093511U CN201043969Y (en) | 2007-05-11 | 2007-05-11 | Biological liquid sample testing apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201093511U CN201043969Y (en) | 2007-05-11 | 2007-05-11 | Biological liquid sample testing apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201043969Y true CN201043969Y (en) | 2008-04-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007201093511U Expired - Lifetime CN201043969Y (en) | 2007-05-11 | 2007-05-11 | Biological liquid sample testing apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201043969Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972496A (en) * | 2010-11-17 | 2011-02-16 | 惠州市华阳多媒体电子有限公司 | Liquid collecting bottle containing sampling cavity |
| WO2011060623A1 (en) * | 2009-11-23 | 2011-05-26 | Alere Switzerland Gmbh | Device for detecting analyte in sample |
| CN107966582A (en) * | 2017-11-10 | 2018-04-27 | 杭州迪图科技有限公司 | A kind of sample collection detector |
| CN112314595A (en) * | 2020-12-01 | 2021-02-05 | 王辉 | Stem cell transport case based on biotechnology |
-
2007
- 2007-05-11 CN CNU2007201093511U patent/CN201043969Y/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011060623A1 (en) * | 2009-11-23 | 2011-05-26 | Alere Switzerland Gmbh | Device for detecting analyte in sample |
| CN101972496A (en) * | 2010-11-17 | 2011-02-16 | 惠州市华阳多媒体电子有限公司 | Liquid collecting bottle containing sampling cavity |
| CN107966582A (en) * | 2017-11-10 | 2018-04-27 | 杭州迪图科技有限公司 | A kind of sample collection detector |
| CN112314595A (en) * | 2020-12-01 | 2021-02-05 | 王辉 | Stem cell transport case based on biotechnology |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai Inverness Medical Co., Ltd. Assignor: Abon Biopharm (Hangzhou) Co., Ltd. Contract record no.: 2010310000067 Denomination of utility model: A biology liquid sample detecting device with a support body Granted publication date: 20080402 License type: Exclusive License Record date: 20100518 |
|
| ASS | Succession or assignment of patent right |
Owner name: ALERE (SHANGHAI) DIAGNOSTICS CO., LTD. Free format text: FORMER OWNER: ABON BIOPHARM (HANGZHOU) CO., LTD. Effective date: 20121018 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 310018 HANGZHOU, ZHEJIANG PROVINCE TO: 201203 PUDONG NEW AREA, SHANGHAI |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121018 Address after: Shanghai city 201203 libing road Zhangjiang High Tech Park No. 151 Building No. 4 floor Patentee after: Meiai Lier (Shanghai) Diagnostics Product Co.,Ltd. Address before: 310018 Hangzhou economic and Technological Development Zone, Zhejiang, No. 12 Main Street (East), No. 198 Patentee before: Abon Biopharm (Hangzhou) Co., Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080402 |