CN103760330B - A kind ofly to collect and the device of analyte in test fluid sample - Google Patents
A kind ofly to collect and the device of analyte in test fluid sample Download PDFInfo
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- CN103760330B CN103760330B CN201310755002.7A CN201310755002A CN103760330B CN 103760330 B CN103760330 B CN 103760330B CN 201310755002 A CN201310755002 A CN 201310755002A CN 103760330 B CN103760330 B CN 103760330B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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Abstract
The invention provides the device of analyte in a kind of test fluid sample, comprising: for holding the test chamber of testing element; For collecting the collecting chamber of fluid sample; Plunger shaft between test chamber and collecting chamber; Piston; One opening; Piston has the first and second positions in plunger shaft, and when piston is positioned at primary importance time, piston chamber is in fluid with collecting chamber by described opening and is communicated with; When piston moves to the process of the second place from primary importance, described opening is by piston seal, and wherein, while this opening is by described piston seal, the fluid be positioned in piston chamber is released in test chamber.By this device, can accurate quantification fluid sample, increase the accuracy of detection and the comfortableness of operation simultaneously.<b />
Description
Technical field
The present invention relates to a kind of pick-up unit, the detection of illegal drug in especially a kind of test fluid sample.
Background technology
At present, it is more and more easier that general public obtains violated medicine, and therefore the use of violated medicine also gets more and more.In order to the fair competition of the safety and physical culture that ensure working environment, enterprise, unit and sports organization need to detect employee, athletic body fluid is such as urinated, to understand employee and whether sportsman employs violated medicine.Therefore, getting more and more of Humoral sample Detection and Collect device, and need to be operated by layman in common occasion.Such as, fluid sample takes out from container, then drips on chemistry or immunoreagent bar.In such operating process, sample and test all can expose outside, can pollute or damage operator or environment.
The device disclosed in existing conventional art, such as US5,119, in 830, pick-up unit is arranged on the bowl cover of urine cup.When opening the bowl cover of urine cup, cup body for the collection of sample and can be deposited.When needing to detect, first gather sample, then the parts of a projection on bowl cover are pressed, barrier film between pick-up unit and cup body is poked, then cup body is inverted certain hour, sample along the breach crushed by projection, can enter the absorbent section of pick-up unit, thus detects from cup body.
Disclose another kind of similar pick-up unit in US6576193B1, rely on the rotation of the piston be arranged between collecting chamber and test chamber to carry out withdrawn fluid sample and detect.Such device due to piston and piston wall airtight not and leak, in addition owing to relying on the rotation of piston to carry out extracting part shunting body sample, also more inconvenience and safety problem can be produced in practical operation, especially, in rotation process, the fluid be positioned in piston is not easy to flow in test chamber, because under airtight space, the transfer of fluid sample seems smooth not, thus causes the non-quantitative of fluid sample, and even the amount of fluid sample can not complete detection very little.
Also another fluid specimen collection and pick-up unit is disclosed in US7270959, disclose the sampling relying on the transverse shifting of piston to realize fluid sample in that patent, but in practical operation, user is needed to expend the movement of larger strength promotion piston, also disclose in addition, the piston hand being used for promoting piston can be separated with piston, and like this in practical operation, piston pushing hands may be lost due to some factor and cannot complete the movement of piston.
In addition, in US Patent No. 6, disclose the urine cup of the edge-on detection of a kind of transverse direction in 726,879B2, this urine cup comprises three chambeies, one is collecting chamber, one is fluid transfer chamber, and one is test chamber, and two bowl covers, one of them bowl cover is used for the sealing of collecting chamber, and whether another one bowl cover is for detecting in sample containing analyte.Introducing the direct contacting with fluid sample in sample application zone by detecting reagent strip upstream in this patent, realizing testing goal.
This is still necessary to provide a kind of new pick-up unit, and not only can carry out quantitative sampling to needing the fluid sample of detection, handled easily simultaneously, improves the accuracy detected, and especially, improves the efficiency of detection and improves quantitative accuracy.
Summary of the invention
On the one hand, the invention provides the device of analyte in a kind of like this collection and test fluid sample, comprising: for holding the test chamber of testing element; For collecting the collecting chamber of fluid sample; Plunger shaft between test chamber and collecting chamber, in plunger shaft, arrange one can the piston of movement.In some preferred modes, by the movement of piston, a part of fluid sample in collecting chamber is transferred in test chamber.
In some preferred modes, in plunger shaft, comprise a piston chamber.In some preferred modes, one end of piston and plunger shaft and the wall of plunger shaft form piston chamber, and this piston chamber can hold the segment fluid flow sample from collecting chamber.In other preferred modes, piston chamber comprises piston, the wall of plunger shaft and one end of plunger shaft, and wherein the wall of piston, plunger shaft and one end of plunger shaft surround described piston chamber.
In a preferred mode, piston has the first and second positions in plunger shaft, and when piston is positioned at primary importance time, piston chamber is in fluid with collecting chamber by opening and is communicated with.Like this, segment fluid flow sample flows to piston chamber from collecting chamber.When piston moves to the process of the second place from primary importance, this opening is sealed, and wherein, while this opening is sealed, the fluid be positioned in piston chamber is released in test chamber.The fluid sample flowed out from piston chamber flows to test chamber, has contacted the analysis and resolution of fluid sample analyte with the testing element be arranged in advance in test chamber.
In some preferred modes, piston comprises a puncturing elements, when piston moves to the process of the second place from primary importance, described opening is sealed, wherein, while opening is sealed, the puncturing elements be positioned in piston chamber pierces through the sealed material that can be punctured, thus, the fluid be positioned in piston chamber is discharged in test chamber by the opening punctured on film.In some preferred modes, sealed material is the film of permeable watertight, like this when piston is mobile in plunger shaft time, before film is not also punctured, gas (if there is) unnecessary in piston chamber can be got rid of, reduce the resistance of piston movement like this, thus more easily promote piston.Preferably, the puncturing elements be positioned on piston is positioned at piston chamber.In some modes, piston and puncturing elements are connected as a single entity.
Preferably, in above-described embodiment, puncturing elements is not positioned at plunger shaft, but film is positioned at outside plunger shaft relatively, so also can arrive the object puncturing film.
In some preferred modes, the other end of plunger shaft is sealed by the sealing-plug that can remove, piston comprises an ejecting structure, it the head of puncturing elements such as, is the shape of non-point, in the process of piston movement in plunger shaft, while opening described in piston seal, this ejecting structure also can eject sealing-plug one end from plunger shaft, thus the segment fluid flow sample in piston chamber is discharged in test chamber.In some preferred modes, described sealing-plug silica gel, rubber, plastic stopper.
In other preferred modes, one end of plunger shaft can be diaphragm seal by the sealed material that can be punctured, this film can be aluminium foil or self-adhesive plastic film or plastic sheeting, these films can allow the piston chamber formed be in airtight space (except being communicated with collecting chamber fluid by first passage), but these films can easily be punctured.
In other preferred modes, when piston moves to the process of the second place from primary importance, the opening between the packed-piston room, outer of piston and collecting chamber, wherein, piston continues to move in piston chamber, and in the process of motion, the outer of piston seals described first passage always.Preferably, continue the volume of the piston compression piston chamber moved in piston chamber, thus, force the fluid sample in piston chamber to enter in test chamber.Preferably, the outer of piston arranges one or more groove, in described groove, arrange elastic seal ring, this elastic seal ring is in sealing by the outer of piston and the inwall of piston.Preferably, when piston outer is in the process of sealing first passage, described elastic seal ring is two, and they lay respectively at the both sides of passage.In other preferred modes, the thickness of the outer of piston or length identical with the degree of depth essence of piston chamber.When piston is in primary importance time, one end of piston is positioned near first passage, and the other end of piston is in plunger shaft, but is not arranged in piston chamber.When piston is in the second place time, be positioned in piston chamber near one end of the piston of first passage, the passage described in the sealing of outer of piston.Like this, piston can be allowed to fill whole piston chamber, the fluid sample in piston chamber is almost pressed in test chamber substantially.
In some preferred modes, in some modes, one end of plunger shaft is by the diaphragm seal that can be punctured, and sealing film has certain elasticity.When piston is mobile in plunger shaft time, especially, in time filling flowing full sample body in piston chamber, in the process of piston relative to one end movement of plunger shaft, force fluid sample moves in piston chamber, piston can be allowed to continue to move to the second place from primary importance to reach, film has certain elasticity, such piston moves in the process of the second place, the elastic film of the packed-piston chamber other end bloats, now, the puncturing elements be positioned at outside piston chamber punctures the elastic film bloated, thus it is powerful that the fluid sample in piston chamber is discharged into detection.Certainly, because have the existence of elastic sealing film, when piston once sealed open time, side can be allowed to break element and puncture film, may also be and be, allow piston continue mobile, allow film bloat, the puncturing elements being arranged on outside punctures.When the outer face seal opening of piston time, just while sealing, puncturing elements punctures film, if piston continues mobile, the piston of movement forces the fluid sample in piston chamber all to enter test chamber by the film be punctured, in this time, the outer of piston still allows opening be sealed.During this time, the volume of piston chamber reduces, or even is reduced to zero.
On the other hand, the invention provides the device of analyte in a kind of test fluid sample, comprising: for holding the test chamber of testing element; For collecting the collecting chamber of fluid sample; Plunger shaft between test chamber and collecting chamber; Piston; One opening; Piston has the first and second positions in plunger shaft, and when piston is positioned at primary importance time, piston chamber is in fluid with collecting chamber by described opening and is communicated with; When piston moves to the process of the second place from primary importance, described opening is by piston seal, and wherein, while this opening is by described piston seal, the fluid be positioned in piston chamber is released in test chamber.
Preferably, described plunger shaft is both ends open, and wherein the one end open of plunger shaft is by piston seal, and the other end opening of plunger shaft is sealed by sealed material.Preferably, described sealed material is what can be punctured, described piston comprises a puncturing elements, when piston moves to the process of the second place from primary importance, the opening arranged between piston chamber and collecting chamber by piston seal, wherein, while this opening is sealed, puncturing elements pierces through the sealed material that can be punctured, thus, the fluid be positioned in piston chamber is discharged in test chamber by thorn sealed material.Preferably, the sealed material that can be punctured is ventilative, fluid-tight material.
Preferably, described sealed material is material that is flexible, that can be punctured, when piston moves to the process of the second place from primary importance, described elastic material is from the other end outwardly convex of plunger shaft, protruding resilient seal material is punctured element and punctures, thus, the fluid sample be positioned in piston chamber is discharged in test chamber by the elastic material punctured.Preferably, described puncturing elements is positioned at the outside of plunger shaft, and towards described flexible, the material that can be punctured.
Preferably, described plunger shaft is both ends open, and one end open is wherein by piston seal, and other end opening is sealed by sealing-plug, described piston comprises one and ejects element, when piston moves to the process of the second place from primary importance, the opening arranged between piston chamber and collecting chamber is sealed, wherein, while this opening is sealed, eject element described sealing-plug is ejected, thus, the fluid be positioned in piston chamber by being discharged in test chamber by the one end of backing down.Preferably, described sealing-plug is silica gel stopper.
In aforementioned all embodiments, preferably, the opening arranged between piston chamber and collecting chamber is sealed by the outer of piston.
In aforementioned all embodiments, preferably, the opening arranged between piston chamber and collecting chamber is by after the sealing of the outer of piston, and piston continues to move in plunger shaft, thus the volume of compression piston room.
In aforementioned all embodiments, preferably, the length of piston is equal with the degree of depth essence of piston chamber, when piston is positioned at primary importance time, one end of piston near the opening between described piston chamber and collecting chamber but and this opening of blow-by, the other end of piston is in plunger shaft and away from the opening between described piston chamber and collecting chamber.
In aforementioned all embodiments, preferably, the width of the opening between described piston chamber and collecting chamber is 3-8 millimeter.
In aforementioned all embodiments, preferably, described piston has groove, elastic seal ring is set in groove, thus the inwall of packed-piston and plunger shaft.
In aforementioned all embodiments, preferably, described piston chamber is surrounded by the opening of the wall in piston, partial piston chamber and the described plunger shaft other end.
In aforementioned all embodiments, preferably, be provided with testing element in described test chamber, fluid sample is urine.
Preferably, in the embodiment of above institute, described first passage or opening are opened on the piston wall of plunger shaft, and the fluid in such collecting chamber keeps fluid to circulate by first passage and piston chamber.
Preferably, in above embodiment, piston and a piston push rod are connected as a single entity.Promote push rod by external force, thus allow piston move in plunger shaft.External force can be manual promotion, also can be to adopt automation structure automatically to promote piston push rod.
Preferably, in the embodiment of above institute, piston push rod arranges a limit element, this element can the initial first position of limited piston in plunger shaft, can avoid mistake push piston like this and cause extraction and the detection of liquid.Preferably, limit element is snap ring, and this snap ring can be separated from push rod.
Preferably, in above embodiment, in test chamber, one or more testing element is comprised.Preferably, testing element comprises immunoassay bar and adulterated test-strips.Preferably, the adsorptive pads of testing element is near the bottom of test chamber.
Beneficial effect
By pick-up unit of the present invention, the automatic acquisition of fluid sample can be realized, automatically detect and reach the object sampling accurate quantification, easily operation, reduces the degree of difficulty of operation, simultaneously simultaneously, such device is more easily produced, and in addition, improves the efficiency of detection.
Accompanying drawing explanation
Fig. 1 is the principle schematic (piston is in primary importance) of one embodiment of the invention;
Fig. 2 is that (piston is in the second place, and sealed open also punctures the other end of plunger shaft for the theory structure schematic diagram of another embodiment of the present invention;
Fig. 3 is the cross-sectional view of another embodiment of the present invention;
Fig. 4 is the principle schematic of another embodiment of the present invention;
Fig. 5 is the principle schematic of one embodiment of the invention;
Fig. 6 is the schematic diagram of inventive piston;
Fig. 7 is the cross-sectional view of the pick-up unit in the present invention's embodiment;
Fig. 8 is the cross-sectional view of the pick-up unit in another embodiment of the present invention;
Fig. 9 is the perspective view of the pick-up unit in another embodiment of the present invention;
Figure 10 is the perspective view of the pick-up unit in another embodiment of the present invention.
Description of reference numerals:
Piston 200; Collecting chamber 80; The opening 40 of collecting chamber; Bayonet arrangement 600; Plunger shaft 100; One end 104 of plunger shaft; The other end 101 of plunger shaft; Opening 103 between piston chamber and collecting chamber; The inwall 102 of plunger shaft; Puncturing elements 300; Piston chamber 70; Piston push rod 400; Push rod lid 500; Piston base 108; Test chamber 10; Testing element 20; Piston outer 201; One end 202 of piston; The other end 205 of piston; Groove 204; 205; The lid 2 of sealing collecting chamber; Sealed material 900.
Describe in detail
Below to relating to structure of the present invention or these technical terms used are described further.
detect
Detect and represent chemical examination or test a kind of material or whether material exists, such as, but be not limited to this, the metabolin of chemical substance, organic compound, mineral compound, metabolism product, medicine or drug metabolite, organic organization or organic organization, nucleic acid, protein or polymkeric substance.In addition, the quantity representing test substances or material is detected.Furtherly, chemical examination also represents immune detection, chemical detection, enzyme detection etc.
sample
The sample of indication of the present invention refers to that those can be used for detecting, chemically examining or diagnose the material that whether there is interested analyte.Sample can be, such as, fluid sample, fluid sample can comprise blood, blood plasma, serum, urine, saliva and various juice, can also comprise the fluid solution that solid sample and semi-solid samples are formed after anticipating.The sample that collection comes may be used for the methods such as immune detection, chemical detection, enzyme detection and detects whether there is analyte.
Sample can be liquid sample, such as liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be water sample, such as seawater, river, river etc., or from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.Such as, throat or genitals sample may be dipped in liquid and make sample.Sample can comprise the potpourri of liquid, solid and gas or any relevant potpourri, the cell suspending liquid in such as dilution or solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be produced from solid, semisolid or high-viscosity materials such as such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.Such as, these solids or semi-solid samples can mix by the solution suitable with dilution one class.Sample can be macerated, freezing and thaw, or other extracting method form liquid sample.Remaining particulate material can use the method that filtration or precipitation etc. are traditional to remove.
analyte
Any analyte can be analyzed by apparatus and method of the present invention.Analyte can detect in any fluid or liquefied sample, such as urine, saliva, saliva, blood, blood plasma, or serum.
The analyte that the present invention refers to can be " drug abuse " (DOA) or other deposit interested material in the sample." drug abuse " (DOA) refers to that non-medical destination uses medicine (usually playing paralysis neural).Abusing these medicines can cause body & mind to suffer damage, and produces dependence, addicted and/or dead.The example of drug abuse comprises cocaine; Amphetamine (such as, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, RochePharmaceuticals, Nutley, NewJersey); Sedative (paramedicines of namely sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, bluedevils, yellowjackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.), opiate (i.e. morphine, opium, codeine, heroin, hydroxyl dihydrocodeinone), anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.This device is used also to may be used for detecting and belong to medical usage but the detection of easy overdose, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or part body fluid exists above-mentioned small-molecule substance.
testing element
Device of the present invention can adopt multiple test-strips, and this is according to being disinclined to the object of analysis thing to be checked and test.Test-strips can be roughly divided into two classes, detects test-strips and anti-adulterated test-strips.Detection test-strips comprises the material for detecting composition to be checked in sample.Anti-adulterated test-strips comprises the material for detecting sample material characteristic.The test-strips of two types all comprises sample application zone and detection zone.
detect test-strips: multiple detection test-strips can be used in the present invention.Detect the test that test-strips comprises analyte in immune detection or chemical detection and detection sample.These analytes comprise: the metabolin of drug abuse or hint health status.
Such as above-described " drug abuse " (DOA) material.For the legal medication of medical object, but incidental dosage is excessive, and test-strips of the present invention also can be adopted to detect.These medicines comprise: three rings resist strongly fragrant dose (imipramine and its analog) and the OTC product (trade mark that being such as positioned at the washingtonian McNeil-PPC company of Pennsylvania, America provides is called the medicine of acenol) containing acetaminophen.The one of the patient that this detection can help emergency rescue personnel to judge stupor whether by accident in these medicines of excessive use.
Can imply that the metabolin in the urine of health status includes but not limited to creatinine, cholerythrin, nitrite, protein (non-specific), hormone is (as human chorionic gonadotrophin, corpus luteum hormone, follicular stimulating hormone etc.), blood, leucocyte, sugar, heavy metal or toxin, bacterial component is (as specific protein or the carbohydrate of Special Category bacterium, such as colon bacillus 0157: H7, staphylococcus, salmonella, fusobacterium, Campylobacter, monocytosis kytoplasm base (L.monocytogenes), vibrio, or cactus bacillus) and physical property, as pH value and proportion.Other Clinical Urinary liquid chemical analyte of quick detection mode that can adopt any can be applied in this device.
Detect test-strips and can have various ways.Generally speaking, test-strips is made up of absorbent material.This absorbent material comprises sample application zone, raw material district and test results zone.Sample is added to sample application zone and by capillary force wet raw material district.In raw material district, sample dissolves and mixes those and detects analysans (if existing in sample) necessary raw material.The sample being mixed with raw material continues moistening test result zone.Extra raw material is fixed on test result zone.One of first group of raw material in these raw materials and analysans (if present) or raw material district reacts.If sample exists analyte really, test section by appearance signal, otherwise then there will not be signal.
As an example more specifically, the detection test-strips that disclosed in following United States Patent (USP) or patented claim, data discloses can be used in the present invention: 5, 252, 496, 5, 415, 994, 5, 559, 041, 5, 602, 040, 5, 656, 503, 5, 712, 170, 5, 877, 028, 5, 965, 458, 6, 046, 058, 6, 136, 610, 6, 140, 136, 6, 183, 972, 6, 187, 268, 6, 187, 598, 6, 194, 221, 6, 194, 224, 6, 221, 678, 6, 228, 660, 6, 241, 689, 6, 248, 598, 6, 271, 046, 6, 297, 020, 6, 316, 205, 6, 372, 514, 6, 338, 969, 6, 368, 873, 6, 372, 516, 6, 375, 896, 6, 375, 897, 6, 391, 652, 6, 403, 383, 6, 418, 606, 6, 429, 026, 6, 464, 939, 6, 468, 474, 6, 485, 982, 6, 506, 612, 6, 514, 769, 6, 528, 323, 6, 548, 019, 6, 730, 268, 2001/0004532, 2001/0021536, 2001/0023076, 2002/0001854, 2002/0004019, 2002/0031840, 2002/0031845, 2002/0052050, 2002/0085953, 2002/0137231, 2002/0173047, 2002/0132267, 2003/0129673, 2003/0207466, 2004/0018636 and 2004/0191760.
anti-adulterated test-strips: prevent that adulterated test-strips is for detecting sample material characteristic or pollution, such as: the pollution of temperature, proportion, pH value, oxidant contamination, glutaconaldehyde, nitrite pollution, ascorbic acid contamination and creatinine pollute.Test purpose for this reason, adopts following test-strips to be desirable.This test-strips incorporates those and defeats and detect for detecting extra chemical substance or other intention and conceal the reagent of drug taking behavior.These test-strips can be used in any form, such as immune detection or chemical detection.In some embodiments, this test-strips can comprise to the chemical examination of creatinine and protein whether diluted to detect urine sample.Anti-adulterated test-strips also can detect Cobastab or other material being intended to defeat detection and joining in urine.These materials comprise: commodity (being provided by the S.C.Johnson company in the Racine city of Wisconsin, USA), soft drink, oxygenant (such as bleaching agent, hydrogen peroxide, pyridine, chromium chloride hydrochlorate) that the commodity (being provided by the Pfizer of New York city,U.S) that glutaraldehyde, nitrite, chromate, vinegar, trade mark are Visine, sodium bicarbonate, trade mark are Drano.
The test-strips of test liquid samples substance characteristics can use together with the present invention.These test-strips comprise for transmit liquid sample by the absorbent material of test-strips, with the filtering element of absorbent material phase fluid connection, with the raw material pad of filtering element phase fluid connection and one optionally transparency cover.Raw material pad includes the raw material for generation of the symbol that can detect, this symbol is relevant to sample properties and observed by the transparent plate (if employed) of transparency cover and this device and obtaining.Described filtering element can by can material manufacture from raw material pad to absorbent material that reflux from of suppression fluid." suppress backflow " refers to that the amount of raw material that the Fluid Volume flowing to absorbent material from raw material pad seldom can not change assay or transfer to absorbent material or adjacent raw material pad from raw material pad seldom detects not out or this testing result can not be made to become indefinite.Test-strips also can comprise the material that do not get wet be placed between a part for filtering material and absorbent material.This material that do not get wet is to suppress sample to reflux to absorbent material from raw material pad.Liquid sample is transmitted through whole test-strips because of capillary action.What " capillary action " referred to that the art personnel know is interacted and the physical influence produced by the inside of liquid and wall or material, and this physical influence can cause liquid to flow through this material." absorbent material " refer to easily attract or absorption fluids material and this material is suitable for capillary action that fluid is transferred to another by the somewhere of this material." filtering element " promotes the even diffusion of sample when sample flows to raw material pad.Thus promote successively on raw material pad, form the symbol that can detect uniformly.Filtering element also suppresses sample to be refluxed to absorbent material by raw material pad, thus also suppresses the chemical substance of raw material to be transferred to another raw material pad by a raw material pad." do not get wet material " refers to the material not allowing the fluid of the quantity that can change testing result to pass.Do not get wet material normally fluid flowing barrier.
The adulterated test-strips of capillary flow of other type also can be integrated in device of the present invention.Such as, the adulterated test-strips disclosed in following listed reference can be applied in the present invention: 2002/0001845,2002/0098512,2002/0155028,2003/0045003,5,922,283,6,248,598,6,514,768,6,537,823 and 6,548,019.
piston and plunger shaft
In the embodiment that some are concrete, plunger shaft 100 can be a cylindrical shape, and be the structure of hollow in the middle of right cylinder, the part of hollow is the cavity of plunger shaft.And the two ends of plunger shaft can be the form of opening.Piston 200 is inserted into plunger shaft from the opening 104 of one end of plunger shaft, and the outer 201 of piston contacts and the one end 104 in packed-piston chamber with the inwall 102 of plunger shaft, allows the fluid sample entering plunger shaft not be leaked to outside plunger shaft.In another mode, the outer 201 of piston has the groove 204,203 of annular, groove is arranged elastic seal ring 501, this elastic seal ring contacts with the inwall 102 of plunger shaft and reaches the effect of sealing, the number of elastic seal ring and the number of groove can be 1, and 2 or multiple, they can be provided separately on piston, when piston is enough thick time, groove can be arranged on the two ends 202,205 of piston outer, installs an O-ring seal 501 in groove respectively.The fluid sample entered in plunger shaft at least can not be leaked between piston outer 201 and the inwall 102 of plunger shaft in such sealing.Except such sealing means, seal with also can adopting its her form such as latch, buckle between piston 200 and plunger shaft 100.
Sealed by sealed material 900 at the other end 101 of plunger shaft.These sealed materials can be the sealed materials be easily punctured, the diaphragm seal that such as can be punctured, the double faced adhesive tape that can be punctured or other diaphragm seal that can be punctured, such as aluminium foil, thin plastic sheet etc.In addition, the sealed material 900 of the packed-piston chamber other end 101 also can be ventilative, fluid-tight sealed material material, or this is ventilative, fluid-tight sealed material material is also easily punctured.The one end 101 sealed by sealed material in plunger shaft and the other end 205 of piston 200 and the inwall 103 of plunger shaft surround piston chamber 70 jointly, this piston chamber 70 is used for receiving the segment fluid flow sample of in collecting chamber 80 by opening 103, this piston chamber 70 also transfers to test chamber 10 li from the fluid sample in collecting chamber in 80 by the motion of piston simultaneously.Like this, piston chamber 70 is limited jointly by the other end 205 of piston 200 and one end 101 of plunger shaft 100 and the wall 103 of piston.
In some modes, in order to allow piston chamber 70 naturally obtain segment fluid flow sample in collecting chamber swimmingly, the wall of plunger shaft having opening 103 or passage, allows collecting chamber 80 be in fluid with piston chamber 70 and be communicated with.Like this, in time having in collecting chamber or collect fluid sample, fluid sample enters into piston chamber by opening or passage naturally, or fills full whole piston chamber.In order to quickly and accurately the fluid sample from collecting chamber 80 li be transferred to test chamber 10 li, piston 200 is when original state, piston is generally positioned near opening 103, or semitight opening or passage, like this when collection in collecting chamber has fluid sample time, due to opening 103 and piston chamber 70 configured in fluid communication, fluid sample in collecting chamber flows in piston chamber naturally, in this time, piston is in primary importance (Fig. 1, Fig. 4).Due to can be punctured diaphragm seal, double faced adhesive tape or other diaphragm seals piston chamber 70 other end 108(during this time, a part of space of plunger shaft 100 li is just restricted to the space of piston chamber 70, and the other end 101 of plunger shaft just becomes the bottom 108 of piston chamber 70 naturally).Piston 200 arranges a puncturing elements 300, and this puncturing elements can puncture the encapsulant 900 of the packed-piston chamber other end.In some modes, this puncturing elements 300 is positioned at piston chamber 70 li and is positioned on piston 200, and, allow one end 301(punctured of puncturing elements puncture sharp keen tartar in other words) and the other end 101 of seal material 900 or plunger shaft between distance be less than or equal to the length of the opening on plunger shaft wall, when piston 200 moves to the other end 101 of plunger shaft in plunger shaft 100, once while outer 201 essence of piston seals this opening 103 completely, puncturing elements 300 also punctures the encapsulant 900 of packed-piston chamber 100 other end 101 simultaneously, like this, the liquid sample being positioned at piston chamber 70 li enters in test chamber by the sealed material punctured immediately, the fluid sample entering test chamber 10 li can contact with testing element 20.Like this, opening 103 sealed and punctured sealed material 900 almost essence complete at synchronization." essence " mentioned here sealed open 103 refers to that the outer of piston seals opening, avoids the fluid sample of collecting chamber 80 li to enter into piston chamber 70 li again.Generally, in the process promoting piston, because velocity ratio is very fast, almost can being completed at synchronization by step and the step puncturing sealed material of opening, this provides for improved efficiency, when particularly operating by hand, adds the comfortableness of operation.
In another preferred mode, the sealed material 900 of one end, packed-piston chamber is ventilative, waterproof material.In other modes, this is ventilative, waterproof material is also the material be easily punctured.
In some other examples, the sealed material 900 of the one end 101 in packed-piston chamber is not the sealing film easily punctured, but a stopper, be such as silica gel stopper.When piston 200 moves in piston chamber 70 or plunger shaft 100 time, opening between the extension 201 sealed open 103(piston chamber and collecting chamber of piston 100 or passage) while, to be arranged on piston 100 and the push rod (puncturing slope element during this time do not have sharp keen tip and become non-sharp keen top) be positioned in piston chamber also along with travelling forward, this push rod bottom packed-piston room 70 108 stopper eject (stopper being also one end, packed-piston chamber), thus the fluid sample made way in piston chamber enters in test chamber.The effect of stopper is adopted to be better than the process puncturing sealed material, because after stopper is ejected, the bottom of whole piston chamber is almost opened, and fluid sample flows in test chamber more easily by the opening made.And puncturing elements was generally punctured an osculum before this, and then tear larger openning (situation relative to plug seal), fluid is not easy to flow out from piston chamber.
In another preferred mode, when piston 200 moves in plunger shaft 100 time, the volume of piston chamber 70 can be compressed.(Fig. 8 when the sealed material of the other end in packed-piston chamber is resilient material time, wherein dotted line position is the state of resilient material when not compressed), the motion of piston can allow these resilient materials 90 outwardly, such as, volume (in concrete mode as above) in compression piston room.In these examples of implementation, puncturing elements 300 not necessarily needs to be positioned in piston chamber, but be positioned at (Fig. 8) outside piston chamber, when piston is positioned at initial position, the tip 301 that the side that element is broken in side is broken near seal element, but can not puncture seal element, and this in time, flexible member can overcome liquid pressure and produce micro-under projection, but such projection not essence be punctured.When piston 200 moves in piston chamber 70 time, the outer 201 of piston once between packed-piston room 70 and collecting chamber 80 opening 103 time, this opening is by the moment sealed, when whole piston chamber is in airtight, piston is moving forward a little a little, such as 1-2 millimeter, under may also be the inertia effect of piston movement, due to the volume of the forces piston room 70 of piston 200, resilient material due to be subject to external force compressing and to the exterior protrusions (Fig. 8) of piston chamber, once summit (the sharp tip of also puncture in time) is broken in the side that the part of projection encounters puncturing elements, this resilient material is punctured, thus the fluid sample discharged in piston chamber is in test chamber.This resilient material is also the material be easily punctured, such as very thin rubber film etc.
In above embodiment, preferred, from piston chamber 70, all flow into test chamber 10 li to allow fluid sample to contact with the testing element 20 in test chamber, it is the same that the fluid sample ensureing in each final device becoming to produce enters the volume of test chamber, allows the thickness h of piston 200
*length or the degree of depth h of (in other words the length on outer 201 edges of piston) essence and piston chamber 70 are consistent, like this, when piston 200 is positioned at initial first position time, one end 205 of piston outer is between piston chamber 70 and collecting chamber 80 near opening 103 (Fig. 4), or piston outer semitight opening, fluid sample in such collecting chamber can arrive in piston chamber smoothly, if having fluid sample in collecting chamber, and such as urine.When piston is positioned at primary importance time, whole piston 200 is positioned at the side of opening and is positioned at plunger shaft 100 li; In time being pushed along with piston, piston outer 201 is once sealed open 103, the puncturing elements 300 be positioned at this time in piston chamber has also punctured the sealed material 900 of packed-piston chamber 100 other end 101 simultaneously, or the push rod be positioned in piston chamber pushes the sealing lid (silica gel cover) of the packed-piston chamber other end 101 open, this time, the fluid sample being positioned at piston chamber 70 li enters in test chamber, also just at the same time, the fluid sample that collecting chamber is 80 li can not enter into piston chamber 70 li again.Along with piston continues to move in piston chamber, in fact, the volume of piston chamber is gradually reduced, piston 200 all can be pressed into all liq of piston chamber 70 li in test chamber, when compression piston room 70, the outer 201 of piston is seal the opening 103 communicated with piston chamber 70 always, and in this time, the liquid sample in collecting chamber would not flow into piston chamber 70 li (Fig. 5) again.In order to allow piston 200 can in motion process sealed open 103 all the time, one or two groove 204 can be opened on the outer 201 of piston, 205, elastic seal ring 501 is set in groove, 502, when piston 200 moves to the bottom of piston chamber 70 (namely the other end 101 of plunger shaft), be separately positioned on piston be on sealed elastic element 501,502 both sides being positioned at opening 103, which increase the effect of piston seal opening.
The such design of the present invention, compared with traditional similar designs, can reach the object of more accurate quantification.Such as, the volume of the piston chamber 216 described in United States Patent (USP) 7270958 is fixed, after piston chamber and collecting chamber 208 opening are sealed, piston chamber's entirety moves to next position, although when arriving next position, partially liq sample in piston chamber can enter test chamber 300, but the amount entered is inaccurate, because the state (the leak of liquid auto levelizer that prevent from enter test chamber outer) of test chamber sometimes also for almost sealing, so the liquid be positioned in piston chamber needs the pressure that overcomes in test chamber and naturally all can not enter into test chamber.But the present invention, because the volume of plunger forces piston chamber, almost can be pressed into the fluid sample in whole piston chamber in test chamber, enters so the present invention has carried out this to traditional design, make the amount of sampling more accurate.And the present invention not only can accurate quantification, and, allow piston can move fast in plunger shaft, decrease the friction force of piston and plunger shaft, make operation more laborsaving.In addition, traditional piston chamber is mass motion, need the inwall of packed-piston and plunger shaft more, guarantee liquid is not leaked out, in order to ensure that liquid is not leaked, must take the acting force increasing piston and plunger shaft inwall, this just adds the acting force promoting piston virtually, adds the difficulty of operation.In actual product uses, when operating personnel need continued operation multiple device time, only need to apply less strength and seem the most important at every turn.The present invention, just from the defect of traditional design, adopts different mentalities of designing completely, decreases the acting force be applied on piston, too increases the efficiency of operation and the accuracy of sample size simultaneously.
In other preferred modes, when the opening 103 designed between collecting chamber and piston chamber or passage, the size of opening is also a very important factor, if opening design is too little, due to capillary effect, the fluid entered in collecting chamber is not easy naturally to flow to piston chamber smoothly, sometimes occurs the situation not being full of piston chamber, or is appeared in piston chamber by drum.If too large, the outer of piston is not easy sealing.Through our experiment, find that the width of the opening of piston is that 5-8 millimeter is best.
Be in allow piston and stable be in primary importance, and do not move in piston chamber 70 easily or move, one end 202 of piston arranges a push rod 400, this push rod and piston are connected as a single entity, push rod arranges a limit fastener 600, by limit fastener 600 can allow piston stable be in initial first position, allow opening 103 stable be in the state opened.Preferably, piston push rod is arranged and pushes away cap 500, the width pushing away cap is greater than the diameter of piston.In time operating, remove buckle 600, allowing piston move in plunger shaft, waiting after moving to suitable distance by pushing away cap 500, because the diameter pushing away cap is greater than the diameter of piston, pushing away cap can only be pushed on the opening of one end of plunger shaft.Like this, the distance of piston in plunger shaft is by piston rod and push away concrete the limiting (Fig. 1-3) of cap.
In some preferred modes, piston, piston push rod, pushing away cap and puncturing elements (or push rod) can by the design disposal molding of mould.
collecting chamber, test chamber and plunger shaft
Collecting chamber 80 is collect the cavity body structure of fluid sample, and collecting chamber can a wall public with plunger shaft, or plunger shaft is positioned at below bottom collecting chamber, keeps fluid to be communicated with by opening 103 and collecting chamber.Collecting chamber 80 has opening, opening can have lid to seal collecting chamber.The volume of collecting chamber can set arbitrarily, such as, be 100-500 milliliter.Test chamber 10 is positioned at the outside of collecting chamber, can arrange testing element 20 in test chamber.The position of collecting chamber of the present invention and plunger shaft and test chamber arrange can with traditional arrange the same, the setting position such as, described in United States Patent (USP) 6576193 and 7270959 can carry out as embodiments more of the present invention, and the material also comprising these component processing is also the plastic material preparation that this area is known.The setting of test chamber and collecting chamber and testing element also can with reference to the specific descriptions of United States Patent (USP) 7270959 li, as a part of the present invention.When testing element is arranged in test chamber time, test chamber can be transparent, like this can by the test result on transparent test chamber read test bar.
In a preferred mode, such as Fig. 7, this device comprises collection chamber 80, and collecting chamber has opening 40, and this opening can be sealed by lid 2.The form of sealing of lid opening can make helicitic texture, may also be the form of latch.Opening 13 is had in the bottom of collecting chamber, opening and plunger shaft are in fluid and are communicated with, and at the other end 103 opening opening of plunger shaft 100, this opening is sealed by sealed material 900, sealing material is the material that can be punctured, such as, can be film, aluminium foil, double faced adhesive tape etc.Piston 200 has the puncturing elements 300 be connected as a single entity.Be test chamber in the outside of the plunger shaft other end 103, in test chamber, be provided with testing element.Piston is provided with groove, in groove, is provided with elastic seal ring 501,502.Piston 200 is arranged on one end of plunger shaft 104.When piston at initial position time, the one end with puncturing elements is positioned at piston chamber 70 li, but not sealed open 103, now, if there is fluid sample to be collected in collecting chamber 80 li, fluid sample, due to Action of Gravity Field, flows in piston chamber naturally.This time, when needs detect time, take off the buckle 600 pre-set on the piston rod, promotion piston 200 moves to the other end 101 of plunger shaft, while sealed open 103, puncturing elements punctures sealed material 900, this time, because opening is sealed, the liquid sample be positioned in collecting chamber is not flowing into piston chamber, meanwhile, because puncturing elements has punctured sealed material 900, be positioned at fluid sample in piston chamber to flow into test chamber and contact with testing element, complete the detection of analyte in fluid sample.In order to better allow the fluid sample in piston chamber enter test chamber, moving in the follow-up reforwarding of piston seal opening 103, the volume of compression piston room, forcing the whole fluid samples be arranged in piston chamber to enter into test chamber completely, complete the accurate quantification of fluid sample.
In another mode, such as Fig. 8, this device comprises collection chamber 80, and collecting chamber has opening 40, and this opening can be sealed by lid 2.The form of sealing of lid opening can make helicitic texture, may also be the form of latch.Opening 13 is had in the bottom of collecting chamber, opening and plunger shaft are in fluid and are communicated with, and at the other end 103 opening opening of plunger shaft 100, this opening is sealed by sealed material 900, sealing material has elasticity and can be punctured, such as rubber film, Emulsoid-film, plastic sheeting.In the outside of the plunger shaft other end 103, just arrange puncturing elements to the opposite of sealed material, now puncturing elements is not positioned in plunger shaft, but is positioned at plunger shaft outside.The outside of the plunger shaft other end 103 is test chamber, in test chamber, be provided with testing element.Piston is provided with groove, in groove, is provided with elastic seal ring 501,502.Piston 200 is arranged on one end of plunger shaft 104.When piston at initial position time, puncturing elements is near sealed material, but do not contact sealed material, now, but piston is positioned at the side of opening 103 not sealed open 103, now, if there is fluid sample to be collected in collecting chamber 80 li, fluid sample, due to Action of Gravity Field, flows in piston chamber naturally.This time, when needs detect time, take off the buckle 600 pre-set on the piston rod, promotion piston 200 moves to the other end 101 of plunger shaft, while sealed open 103, puncturing elements punctures sealed material 900, this time, because opening is sealed, the liquid sample be positioned in collecting chamber no longer flow into piston chamber, simultaneously, because puncturing elements has punctured sealed material 900, be positioned at fluid sample in piston chamber to flow into test chamber and contact with testing element, complete the detection of analyte in fluid sample, because while piston seal opening, because piston continues motion in piston chamber, in fact allow air pressure in piston chamber increase, the air pressure increased forces to be had flexible sealing film and bulges, the surface of the elastic film bloated is once contact puncturing elements, just be punctured element to puncture, discharge fluid sample in test chamber.In order to better allow the fluid sample in piston chamber enter test chamber, moving in the follow-up reforwarding of piston seal opening 103, the volume of compression piston room, forcing the whole fluid samples be arranged in piston chamber to enter into test chamber completely, complete the accurate quantification of fluid sample.
In another embodiment, as shown in Figure 9, other identical with the embodiment shown in Fig. 7, difference is: on piston, arrange the piston push rod 400 be connected as a single entity, piston push rod is arranged and pushes away cap 500, plunger shaft 100 is positioned at the bottom of collecting chamber, and on piston wall, open an opening 103, the width of opening is 3-8 mm wide, simultaneously, piston push rod arranges buckle structure 600, and buckle structure limited piston is stably in initial first position in plunger shaft, that is: blow-by opening 103.When needs operate time, remove buckle structure 600, push away cap 500, thus allow piston move in plunger shaft, while piston seal opening, piston forces the fluid sample in plunger shaft to enter in test chamber.The mode entering test chamber can the one in the concrete mode shown in Fig. 1-8 be carried out, such as puncturing elements punctures sealed material or ejects element and ejects sealing cap or allow sealed material have elasticity, allows the puncturing elements side slope flexible member etc. be arranged on outside piston chamber.Certainly, also can make to be to better allow the fluid sample in piston chamber enter test chamber, moving in the follow-up reforwarding of piston seal opening 103, the volume of compression piston room, force the whole fluid samples be arranged in piston chamber to enter into test chamber completely, complete the accurate quantification of fluid sample.
In another mode, such as Figure 10, other identical with the embodiment shown in Fig. 7, difference is: one end 101 opening of plunger shaft, opening arranges a sealing plug (being such as silica gel stopper) and seals up this opening, piston arranges a bar, along with the motion of piston, when piston outer 201 sealed open 103, push rod ejects stopper in test chamber, the fluid sample be positioned in piston chamber is discharged in test chamber simultaneously, has contacted the detection of analyte with testing element.In order to better allow the fluid sample in piston chamber enter test chamber, moving in the follow-up reforwarding of piston seal opening 103, the volume of compression piston room, forcing the whole fluid samples be arranged in piston chamber to enter into test chamber completely, complete the accurate quantification of fluid sample.
Embodiment
Be described in detail the specific embodiment of the present invention by reference to the accompanying drawings now, this explanation is not carry out any restriction to the claims in the present invention, and is used to illustrate how to realize the present invention, belongs to a concrete mode of the present invention.
Specific embodiment
According to US7270959 patent disclosed in method manufacture the product of 1000, manufacture device of the present invention 1000 products simultaneously.The collecting chamber volume (450 milliliters) of the product that US7270959 patent (contrast) describes is identical with the product of apparatus of the present invention with the volume (25 milliliters) of containing fluid sample in plunger shaft, in addition, collecting chamber is the same with position with the size of the opening of plunger shaft, and the volume of plunger shaft too.Water or the urine specimen of 300 milliliters is filled in each product, operate according to the method for each self-described, contrast United States Patent (USP) (US7270959) allows piston have three kinds of states, and the design of piston of the present invention is different from the design of the piston of contrast US Patent No. 7270959, mode of operation also occurs that essence is different.Meanwhile, compare the difference of the volume of the sample transferred in test chamber, the time difference of compare operation simultaneously.
Table 1 device of the present invention compares the comparison of parameter with the device of contrast 1.
| Leakage ratio | Arrive the urine liquid volume of test chamber | Arrive the water volume of test chamber | Arrive the liquid volume of piston chamber | Running time | |
| Contrast | 20/1000 | 15.2 milliliters (on average) | 14.3 milliliters (on average) | 23.2 milliliters (on average) | 2.3 second |
| The present invention | 12/1000 | 24.3 milliliters (on average) | 23.8 milliliters (on average) | 24.8 milliliters (on average) | 1.5 seconds. |
Table 2 device of the present invention with contrast 1 device comfort level and firmly compare.
| Exerting oneself of push piston | Comfort level | |
| Contrast | 200.4 newton | 200(10 divides); 300(8 divides); 400(6 divides); 100(3 divides) |
| The present invention | 120.45 newton | 400(10 divides); 500(8 divides); 80(6 divides); 20(3 divides) |
Have passed through more than 1000 common operator to operate, grade to comfort level, grading is that standard is as follows: 10 are divided into the most comfortable, 8 be divided into comfortable; 6 are divided into generally; 3 be divided into uncomfortable.
Claims (7)
1. collecting and the device of analyte in test fluid sample, comprising: for holding the test chamber of testing element; For collecting the collecting chamber of fluid sample; Plunger shaft between test chamber and collecting chamber; Piston; The opening arranged between piston chamber and collecting chamber; Piston has the first and second positions in plunger shaft, and when piston is positioned at primary importance time, piston chamber is in fluid with collecting chamber by described opening and is communicated with; When piston moves to the process of the second place from primary importance, described opening is by piston seal, and wherein, while this opening is by described piston seal, the fluid be positioned in piston chamber is released in test chamber; Described plunger shaft comprises the two ends of opening, and wherein, the one end open of plunger shaft is by piston seal, and the other end opening of plunger shaft is sealed by sealed material; Described sealed material is material that is flexible, that can be punctured, when piston moves to the process of the second place from primary importance, described resilient seal material is from the other end outwardly convex of plunger shaft, protruding resilient seal material is punctured element simultaneously and punctures, thus, the fluid sample be positioned in piston chamber is discharged in test chamber by the elastic material punctured.
2. device according to claim 1, wherein, described puncturing elements is positioned at the outside of plunger shaft, and towards described flexible, the material that can be punctured, only have when resilient seal material projection time, puncturing elements just punctures described resilient seal material.
3. device according to claim 1, wherein, the opening arranged between piston chamber and collecting chamber is sealed by the outer of piston.
4. device according to claim 1, wherein, the opening arranged between piston chamber and collecting chamber is by after the sealing of the outer of piston, and piston continues to move in plunger shaft, thus the volume of compression piston room.
5. device according to claim 1, wherein, the length of piston is equal with the degree of depth essence of piston chamber, when piston is positioned at primary importance time, one end of piston near the opening between described piston chamber and collecting chamber but and this opening of blow-by, the other end of piston is in plunger shaft and away from the opening between described piston chamber and collecting chamber.
6. device according to claim 1, wherein, the width of the opening between described piston chamber and collecting chamber is 5-8 millimeter.
7. device according to claim 1, wherein, described piston chamber is surrounded by the opening of the wall in one end of piston, partial piston chamber and the described plunger shaft other end.
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| CN201310755002.7A CN103760330B (en) | 2013-12-31 | 2013-12-31 | A kind ofly to collect and the device of analyte in test fluid sample |
| US14/318,489 US9352313B2 (en) | 2013-12-31 | 2014-06-27 | Device for collecting and testing analyte in a liquid sample |
| EP14200592.5A EP2889086B1 (en) | 2013-12-31 | 2014-12-30 | A device for collecting and testing analyte in a liquid sample |
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| CN106732835B (en) * | 2015-11-21 | 2020-09-15 | 艾博生物医药(杭州)有限公司 | Collection detection device of fluid sample |
| CN105784443B (en) * | 2016-03-16 | 2018-12-07 | 杭州安旭科技有限公司 | A kind of sample testing apparatus and sample collection detection device and method |
| CN107290515A (en) * | 2016-04-11 | 2017-10-24 | 福因德科技（武汉）有限公司 | High flux immunoassay device |
| CN106399053B (en) * | 2016-11-14 | 2019-07-05 | 湖南圣湘生物科技有限公司 | A kind of PCR reaction unit and its application method |
| CN106841586B (en) * | 2017-01-22 | 2018-12-18 | 英科新创(厦门)科技有限公司 | A kind of integration chromatography detection device |
| CN106841587B (en) * | 2017-01-22 | 2018-12-18 | 英科新创(厦门)科技有限公司 | A kind of integration chromatography detection device |
| CN107576809A (en) * | 2017-09-30 | 2018-01-12 | 江苏宝卫士生物科技有限公司 | A kind of real-time test device |
| CN107817358B (en) * | 2017-12-14 | 2023-11-07 | 江苏宝卫士生物科技有限公司 | Diagnostic reagent detection device and method thereof |
| CN110567748B (en) * | 2019-07-25 | 2022-07-01 | 杭州迪图科技有限公司 | Device for sampling |
| CN110907371B (en) * | 2019-11-26 | 2022-12-13 | 中国地质调查局水文地质环境地质调查中心 | On-site detection reagent tube for ferric ions in water and detection method |
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| CN2763795Y (en) * | 2004-11-04 | 2006-03-08 | 艾康生物技术(杭州)有限公司 | Body fluid sample collection detector |
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| CN101876661A (en) * | 2009-05-08 | 2010-11-03 | 艾博生物医药(杭州)有限公司 | Device for analyzing analyte in liquid sample |
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| US7270959B2 (en) * | 2001-07-25 | 2007-09-18 | Oakville Hong Kong Company Limited | Specimen collection container |
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| CN2763795Y (en) * | 2004-11-04 | 2006-03-08 | 艾康生物技术(杭州)有限公司 | Body fluid sample collection detector |
| WO2010003310A1 (en) * | 2008-07-07 | 2010-01-14 | Lv Xinlong | Detection device for fluid sample |
| CN101464457A (en) * | 2008-07-23 | 2009-06-24 | 吕欣龙 | Detecting instrument for liquid sample |
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