CN213302249U - Cup body for collecting samples - Google Patents

Abstract

The utility model provides a cup for collecting sample, including third chamber and liquid-transfering channel, third chamber and liquid-transfering channel can be in the state of liquid intercommunication or wall, and the sample of collecting in the third chamber can flow into liquid-transfering channel naturally in, perhaps the sample of collecting in the third chamber can be in liquid-transfering channel under the exogenic action. The cup body can separate the collected sample, so that the sample needing secondary confirmation detection is separated from the sample needing primary detection, can be independently sealed and sent to a detection mechanism for confirmation detection.

Description

Cup body for collecting samples

Technical Field

The present invention relates to devices for collecting liquid samples, and more particularly to devices for collecting and detecting analytes in liquid samples, such as urine collection and detection devices, in the field of rapid diagnostics.

Background

Currently, a large number of test devices for detecting whether a sample contains an analyte are used in hospitals or homes, and these test devices for rapid diagnosis include one or more test reagent strips, such as an early pregnancy test, a drug abuse test, and the like. The rapid diagnosis test device is convenient, and can obtain the test result on the test reagent strip within one minute or at most ten minutes.

Drug detection is widely applied and is commonly used in drug-resistant departments, public security bureaus, drug rehabilitation centers, physical examination centers, national soldier physical examination places and other institutions. The drug detection urine cup has various drug detection types and frequent times, and has a huge market demand, and after the drug detection urine cup on the market finishes detection, the sample in the urine cup is polluted by the detection reagent and cannot be continuously used for secondary confirmation detection, for example, as described in U.S. patent 7300633.

Although, in the conventional technique, the sample to be tested can be isolated from the collected sample, it is costly and not easy to handle. For example, U.S. patent No. 7300633 describes a piston urine cup that allows a liquid sample, such as urine, in a collection chamber to be transferred from the collection chamber to a detection chamber during advancement of a piston, where a test element is located to detect an analyte in the sample, and the liquid sample in the collection chamber is separated by the piston so that the two samples do not mix, and can be used for subsequent confirmatory testing. Although the detected sample and the collected sample can be separated, the urine cup of the piston is high in cost and difficult to operate, and after all, the piston needs to be pushed by a large force, so that the sample needs to be transferred by the piston, the liquid sealing effect needs to be achieved with the wall of the piston, and the piston cavity need to be tightly combined to achieve the sealing effect.

For another example, U.S. patent 8992855 describes a device for collecting a liquid sample that includes a piston structure integral with and movable with a cap, and that, while allowing separation of the test sample from the collected sample, requires a large amount of pressure to be overcome to access the test sample after it has entered the test chamber, and requires the cap and cup to be precisely dimensioned so that the piston integral with the cap can be accurately inserted into the separation chamber.

In addition, after the initial tests of these conventional collecting and detecting devices are completed, if the subsequent confirmation tests are required, the whole collecting and detecting device needs to be transported to a confirmation and detection mechanism for further confirmation tests, which brings about many problems, at least such problems: first, most current liquid collection and testing devices are provided with only a preliminary testing chamber. If subsequent confirmation detection is required, the whole device containing the urine and the detection reagent strip can only be sent to a confirmation detection mechanism for detection. The sample in the urine cup may be contaminated with the detection reagent. Secondly, when the whole device is sent to the confirmation detection mechanism, the risk of liquid leakage exists in the transportation process due to the fact that the cup opening is large, and therefore more cost is needed to enable the device to have a better sealing effect, and the risk of leakage is reduced as much as possible; third, after the entire device is transported to the confirmation and inspection mechanism, the confirmation and inspection mechanism requires a large low-temperature warehouse to store the entire device, preventing the liquid sample from deteriorating, and preparing for possible further confirmation and inspection later, which causes a significant increase in the cost of the confirmation and inspection mechanism (which may be referred to as a secondary inspection mechanism).

In view of the above technical problems, it is desirable to improve the above and provide an alternative way to overcome the shortcomings of the conventional technologies.

SUMMERY OF THE UTILITY MODEL

To the above situation, for overcoming the defect of prior art, the utility model aims to solve the technical problem that a cup for collecting the sample is provided, this cup can separate the sample of collecting, makes the sample that needs to carry out the secondary and confirm the detection separate with the sample of initial detection, can independently seal and be sent to detection mechanism and confirm the detection. The utility model discloses a cup can be with collecting in the sample divides the different cavities, and the cavity of difference can realize partial intercommunication or cut off according to the needs of collecting, separation or detection, obtains the secondary through once collecting and detects required sample and can save respectively, confirms that can not pollute between the sample that detects and the sample and the test element of initial detection, ensures can not influence the effect that the secondary was confirmed.

In order to solve the technical problem, the utility model provides a following technical scheme:

a cup body for collecting samples comprises a third cavity and a pipetting channel, wherein the third cavity and the pipetting channel can be in a liquid communication or separation state, the samples collected in the third cavity can naturally flow into the pipetting channel, or the samples collected in the third cavity can be transferred into the pipetting channel under the action of external force.

Further, the pipetting channel is located below the third chamber.

Further, the cup includes a first channel for placing the pipetting channel in fluid communication with the third chamber.

Further, the first channel is located at the bottom of the third chamber.

Further, the first channel can be closed or opened.

Furthermore, a collecting groove is formed in the side wall of the first channel, and the collecting groove is flush with the bottom of the third cavity or slightly higher than the bottom of the third cavity.

Further, the collecting gutter can be closed off separately or simultaneously with the first channel.

Further, the cup includes a second channel for placing the pipetting channel in fluid communication with the third chamber.

Further, the second channel can be closed or opened.

Further, a detection area is included.

Further, a detection inlet for placing the pipetting channel in fluid communication with the detection area is included.

Further, the liquid in the pipetting channel can enter the detection area under the action of an external force.

The following technical scheme also belongs to the content of the utility model:

the utility model discloses an in the first aspect, the utility model provides a sample detection device, including the first chamber that is used for collecting the liquid sample and the second chamber that is used for collecting the confirmation detection sample, first chamber and second chamber can be in liquid intercommunication or the state of cutting off, and when first chamber and second chamber were in liquid intercommunication state, the liquid of first intracavity can be shifted to the second intracavity under the exogenic action.

In some preferred forms, the external force may be the action of gravity. In some preferred forms, the external force is a force other than gravity. In some preferred forms, other forces than gravity include contact and/or non-contact pressure, thrust, squeezing, and the like. In some preferred forms, the external force may be a force that overcomes gravity. In some preferred forms, the external force may be a force other than against gravity, such as breaking a blockage or passing through an opening. In some preferred forms, the external force may be a force generated within the structure. In some preferred forms, the external force may be a force developed within the structure by the structure or by a fit, such as an impulse force created by a pressure differential or an attractive force created by a negative pressure or vacuum. In some preferred embodiments, the second chamber may be provided with a vacuum, and in the case where the first chamber and the second chamber are in fluid communication, fluid may flow from the first chamber to the second chamber due to the pressure differential. In some preferred modes, the second cavity does not need to be completely vacuum, and the pressure difference effect can be realized as long as the internal pressure of the second cavity is smaller than that of the first cavity. In some preferred forms, the first chamber may be pressurized, and the above-described pressure differential effect may also be achieved.

In some preferred embodiments, the first chamber is capable of collecting the sample directly, or the first chamber is capable of communicating with another chamber to receive the sample directly or indirectly, and the receiving is not assisted by an external force, for example, the first chamber has an opening directly for receiving the sample, or an opening in fluid communication with another chamber for receiving the sample directly, and the sample can slide into the first chamber through the other chamber under the action of gravity, which can be achieved naturally by the collecting process without an external force.

In some preferred modes, the first cavity and the second cavity are in a liquid isolation state under the condition of no external force, namely, the first cavity and the second cavity are not in liquid communication; under the condition that the external force is applied, the second cavity can be in liquid communication with the first cavity, under the condition that the first cavity is in liquid communication with the second cavity, the sample in the first cavity can be transferred into the second cavity under certain pressure, namely, certain external force must be applied to the sample in the first cavity to be transferred into the second cavity, the process cannot be realized through natural power (such as gravity), after the second cavity collects a proper amount of sample, the external force is removed, and the first cavity and the second cavity can be restored to the liquid isolation state. In some preferred embodiments, the external force for causing the first chamber and the second chamber to be in the liquid communication state and the external force for causing the sample in the first chamber to be transferred into the second chamber may be the same external force, and in some preferred embodiments, the external force for causing the first chamber and the second chamber to be in the liquid communication state and the external force for causing the sample in the first chamber to be transferred into the second chamber may be different external forces.

As a possible implementation, for example, the first chamber has an opening to the second chamber, the opening is normally closed when not pressurized and is openable when pressurized, so that the collected liquid in the first chamber can enter the second chamber through the opening when pressurized, and when the pressure is removed, the opening is closed again to complete the transfer of the sample in the first chamber to the second chamber.

As a possible implementation manner, a communicating vessel may be disposed between the second chamber and the first chamber, and the communicating vessel may communicate the interiors of the first chamber and the second chamber under a certain condition (e.g., receiving pressure), so that the first chamber and the second chamber are in fluid communication, in which case, the sample in the first chamber may be transferred into the second chamber, and after the transfer is completed, the communicating vessel may be removed, so that the second chamber is closed.

As a possible implementation manner, the communicating vessel may have a puncture, the second chamber has a sealing port, the sealing port can be punctured by the puncture, and after the communicating vessel is removed, the sealing port can recover liquid sealing, for example, a rubber seal is adopted, the puncture can be punctured into the sealing port under the action of external force to communicate the first chamber with the second chamber, and the liquid in the first chamber can enter the second chamber through the puncture under the condition of pressure.

The second aspect of the utility model provides a third chamber for initially collecting the sample, third chamber and first chamber can be in liquid intercommunication or the state of cutting off with the first chamber.

In some preferred modes, the third cavity can be in natural liquid communication with the first cavity, that is, the liquid in the third cavity can naturally flow into the first cavity without external force, and in some preferred modes, the liquid in the first cavity can naturally flow into the third cavity without external force.

In some preferred manners, the third chamber and the first chamber are in a liquid communication state under the action of an external force, that is, the fluid in the third chamber does not actively flow into the first chamber, and a certain external force is applied to realize the flow of the fluid from the third chamber to the first chamber. In some preferred modes, the fluid in the first cavity does not actively flow into the third cavity, and certain external force is required to be applied to realize the flow of the fluid from the first cavity to the third cavity.

In some preferred manners, the third chamber and the first chamber are in a liquid separation state, that is, the liquid in the first chamber cannot flow into the third chamber, and the liquid in the third chamber cannot flow into the first chamber, and this separation state can be broken by an external force, that is, in some possible cases, the liquid communication state between the first chamber and the third chamber can be realized by an external force. For example, in some preferred embodiments, the sample is initially collected in the third chamber, and the sample does not enter the first chamber without force.

In some preferred forms, the third chamber may serve as a chamber for initially collecting a sample, as described in the first aspect, the first chamber or the third chamber may serve as a chamber for initially collecting a sample, and the first chamber and the third chamber may also be in fluid communication, so that a fluid sample collected in the third chamber may flow into the first chamber to collect a sample in the first chamber.

In some preferred forms, the first chamber and the third chamber have a first passageway therebetween in fluid communication through which fluid may pass from the first chamber into the third chamber or from the third chamber into the first chamber. In some preferred modes, the first channel is positioned at the bottom of the third cavity, so that the sample entering the third cavity can naturally flow into the first cavity under the action of self gravity.

In some preferred forms, the first passage between the first chamber and the third chamber may be closed, and when the first passage is closed, the first chamber and the third chamber are in a liquid-blocking state, for example, in some preferred forms, the sample first enters the third chamber and may flow into the first chamber along the aforementioned first passage, and the liquid in the first chamber may enter the second chamber under the action of external force, and in some preferred forms, when the first chamber and the second chamber are in a liquid-communicating state, the first passage may be closed.

In some preferred modes, the first cavity is positioned at the bottom of the third cavity, and when the first cavity is communicated with the third cavity in a fluid mode, liquid in the third cavity can directly flow into the first cavity under the action of self weight.

In some preferred modes, the fluid in the third chamber cannot naturally flow into the first chamber under the action of gravity, for example, the first chamber and the third chamber are separated in a natural state, and the communication port of the first chamber and the third chamber can be opened only under a certain pressure, in this case, the sample can be preferentially loaded into the third chamber, and then under a certain pressure, for example, the extrusion force generated by covering the cover body, the sample in the third chamber can be extruded downwards and forced into the first chamber.

In some preferred forms, the third chamber is preferentially filled with the sample. In some preferred modes, the sample in the third cavity can enter the first cavity under the action of certain external force.

In some preferred forms, the first chamber may be provided with a third channel through the third chamber, which third channel is not filled with sample during initial collection. In some preferred forms, the second chamber may be fitted directly to the third channel. In some preferred embodiments, the third channel and the third chamber have a common opening, but care is taken when loading the sample so that it does not enter the third channel. In some preferred forms, the third channel may be closed, for example by a plug, or by a membrane, at the initial collection of the sample.

In some preferred modes, the bottom of the third cavity is provided with openings which can be communicated with the first cavity. In some preferred modes, the first cavity and the third cavity are communicated through a pressure hole, when pressure is applied to the third cavity, the pressure hole is opened, fluid can directly enter the first cavity from the third cavity, and when the pressure is removed, the pressure hole can be closed again. In some preferred forms, the pressure port is capable of withstanding the liquid pressure of the third chamber in the closed state, i.e. simply by loading the third chamber with samples which do not have sufficient weight to open the pressure port. In some preferred ways, the pressure port can be opened when a certain amount of sample is collected. In some preferred modes, the pressure which can be borne by the pressure hole can be configured according to actual needs.

The utility model discloses a third aspect, the utility model provides a fourth chamber for collecting wait to detect sample, the fourth chamber can be in liquid intercommunication or the state of cutting off with the third chamber.

In some preferred modes, the third cavity can be in natural liquid communication with the fourth cavity, that is, the liquid in the third cavity can naturally flow into the fourth cavity without external force, and in some preferred modes, the liquid in the fourth cavity can naturally flow into the third cavity without external force.

In some preferred manners, the third chamber and the fourth chamber are in a liquid communication state under the action of an external force, that is, the fluid in the third chamber does not actively flow into the fourth chamber, and a certain external force is applied to realize the flow of the fluid from the third chamber to the fourth chamber. In some preferred modes, the fluid in the fourth cavity does not actively flow into the third cavity, and certain external force is required to be applied to realize the flow of the fluid from the fourth cavity to the third cavity.

In some preferred manners, the third chamber and the fourth chamber are in a liquid separation state, that is, the liquid in the first chamber cannot flow into the third chamber, and the liquid in the third chamber cannot flow into the fourth chamber, and this separation state can be broken by an external force, that is, in some possible cases, the liquid communication state between the fourth chamber and the third chamber can be realized by an external force.

In some preferred forms, as mentioned in the second aspect, the third chambers may be used as chambers for initially collecting samples, and the fourth chamber and the third chamber may also be in fluid communication, so that the fluid sample collected in the third chamber may flow into the fourth chamber to collect the sample in the fourth chamber.

In some preferred forms, the fourth chamber and the third chamber have a second passageway therebetween in fluid communication through which fluid may pass from the third chamber into the fourth chamber or from the fourth chamber into the third chamber. In some preferred modes, the second channel is located at the bottom of the third chamber, so that the sample entering the third chamber can naturally flow into the fourth chamber under the action of self gravity.

In some preferred embodiments, the second channel between the fourth chamber and the third chamber may be closed, and when the second channel is closed, the fourth chamber and the third chamber are in a liquid-blocking state, for example, in some preferred embodiments, the sample first enters the third chamber and can flow into the fourth chamber along the aforementioned second channel, and the liquid in the fourth chamber can enter the detection area under the action of external force, and in some preferred embodiments, the second channel may be closed when the fourth chamber and the detection area are in a liquid-communicating state.

The fifth aspect of the utility model provides a lid for covering closes sample collection mouth. In some preferred forms, the cover may act as a sealing element for the entire device. In some preferred forms, the cap may cover the sample collection port of the sample collection device.

As previously discussed, the second chamber may be in fluid communication with the first chamber such that there is a positional and mating relationship between the second chamber and the first chamber. In some preferred forms, the second chamber and the first chamber may be combined or separated. In some preferred forms, the second and third chambers may be combined or separated.

In some preferred forms, the second chamber is mounted on the cap. In some preferred forms, the second chamber is removably connected to the lid. In some preferred modes, the cover body is provided with a fitting channel of the second cavity. In some preferred forms, the second chamber is removably connected to the assembly channel. In some preferred forms, the assembly channel may be closed.

In some preferred forms, the cover may be fitted to the third chamber. In some preferred forms, the second chamber is in fluid communication with the first chamber when the cover is closed over the third chamber. In some preferred modes, when the cover body is covered with the third cavity, the communicating vessel punctures the second cavity so that the first cavity is in liquid communication with the second cavity. In some preferred forms, when the cover is closed over the third chamber, the assembly channel engages and seals the first channel, placing the third chamber and the first chamber in fluid communication.

In some preferred forms, the cover may be fitted to the first chamber. In some preferred forms, the second chamber is in fluid communication with the first chamber when the cover is closed over the first chamber. In some preferred modes, when the cover body is covered with the first cavity, the communicating vessel punctures the second cavity so that the first cavity is in liquid communication with the second cavity.

The utility model discloses a fifth aspect, the utility model provides an assembly structure of second chamber, assembly structure can with the passageway cooperation in the lid, pack into the lid with the second chamber or from it takes out. In some preferred forms, the mounting structure is removably coupled or connected to the cover. In some preferred forms, the removable attachment is a threaded connection. In some preferred forms, the removable attachment is a bayonet fitting.

In some preferred forms, the mounting structure is capable of securing the second chamber therein. In some preferred forms, the mounting structure has a grip element to facilitate coupling or decoupling of the mounting structure and the cover. In some preferred forms, the mounting structure has a knob member for facilitating coupling or decoupling of the mounting structure and the cover. The purpose of the handle member and the knob member is to facilitate the coupling and decoupling of the mounting structure and the cover. In some preferred forms, the cap may be plugged with a plug after the assembly structure and cap are separated. In some preferred forms, the cover may be plugged with a plug prior to assembly of the assembly structure and the cover to prevent dust or contamination from falling into the space within the cover for receiving the assembly structure.

In some preferred modes, the assembling structure is provided with a plurality of hollow structures, and a certain external force, such as extrusion, can be applied to the second cavity through the hollow structures, so that the sample in the second cavity flows out.

The utility model discloses an in the sixth aspect, the utility model provides a communicating vessel, communicating vessel are used for communicateing first chamber or second chamber or make and realize the liquid intercommunication between first chamber and the second chamber. In some preferred forms, the communicating vessel itself also has a chamber (which may be referred to as a communicating chamber). In some preferred modes, when the communicating vessel is communicated with the first cavity, the cavity inside the communicating vessel is in liquid communication with the first cavity. In some preferred modes, when the communicating vessel communicates with the second chamber, the communicating chamber inside the communicating vessel is in liquid communication with the second chamber. In some preferred modes, the communication cavity inside the communicator is in liquid communication with the first cavity and the second cavity.

In some preferred forms, the communicating vessel and the second chamber can be combined or separated. In some preferred forms, the communicating vessel is in fluid communication with the second chamber in a manner that punctures the second chamber. In some preferred modes, after the communicating vessel and the second cavity are separated, the second cavity is naturally closed. In some preferred forms, the communicating vessel and the second chamber are detachably combined.

In some preferred forms, the communicator may be mounted directly on the first passage. In some preferred forms, the communicator may be mounted on the first passage with the cover. In some preferred modes, the communicating vessel is detachably connected or combined with the assembly channel on the cover body. In some preferred modes, the communicating vessel can be arranged on the assembly channel, the communicating vessel and the cover body can synchronously move, and the communicating vessel can cover the first channel along with the cover body. In some preferred modes, the sample to be collected by the second cavity can enter the communicating vessel from the first channel and then enter the second cavity from the communicating vessel.

In some preferred modes, the communicating vessel communicates with the first chamber through the first passage. In some preferred modes, the communicating vessel can enable the first passage and the third cavity to be in a liquid separation state when the communicating vessel communicates with the first cavity.

The seventh aspect of the utility model provides a second chamber for collecting the secondary and confirm the sample that detects, the second chamber is used for collecting and depositing the secondary and confirms the sample that detects. In some preferred forms, the second chamber receives a sample from the first chamber. In some preferred forms, the second chamber is capable of being sealed naturally. In some preferred forms, the second chamber can be sealed after a sufficient amount of sample has been collected. In some preferred forms, the volume of the second chamber is variable. In some preferred forms, the second cavity may be a flexible cavity. In some preferred embodiments, the second chamber may be under vacuum before being filled with the sample. In some preferred forms, the second chamber may be sealed by a rubber stopper. In some preferred modes, the communicating vessel can pierce the rubber plug, and the rubber plug can keep sealing under certain pressure conditions after the communicating vessel is removed, so that the second chamber has the functions of sealing and storing the liquid sample.

In some preferred forms, the second chamber is detachably joined or connected directly to the first chamber. In some preferred forms, the second chamber is removably coupled or connected to the first chamber by a cover. In some preferred forms, the second chamber is removably coupled or connected to the cover by a mounting structure.

In some preferred forms, the second chamber is removably connected to the mounting structure. In some preferred forms, the second chamber may be placed into the mounting structure. In some preferred modes, the assembling structure is provided with a plurality of hollow structures, and a certain external force, such as extrusion, can be applied to the second cavity through the hollow structures, so that the sample in the second cavity flows out. In some preferred embodiments, the second chamber has an opening that can remain closed when not under pressure, or within a range of pressures, to allow a volume of sample to be stored in the second chamber, the sample having insufficient hydraulic pressure to open the opening, and the opening being openable when under sufficient pressure to allow the second chamber to be in fluid communication with an external or other chamber, such as by squeezing or otherwise compressing the opening.

In some preferred forms, the second cavity may be a rigid cavity. In some preferred forms, the second cavity may be a flexible cavity. In some preferred embodiments, the second chamber changes shape and volume after being filled with the sample. In some preferred modes, the second chamber may be configured to have a smaller internal pressure, for example, a smaller internal pressure than the first or third chamber, so that the sample in the first or third chamber can be transferred into the second chamber by the pushing force generated by the pressure difference or the suction force generated by the negative pressure or vacuum. In some preferred embodiments, the second chamber may be provided with a vacuum, and in the case where the first chamber and the second chamber are in fluid communication, fluid may flow from the first chamber to the second chamber due to the pressure differential. In some preferred modes, the second cavity does not need to be completely vacuum, and the pressure difference effect can be realized as long as the internal pressure of the second cavity is smaller than that of the first cavity. In some preferred forms, the first chamber may be pressurized, and the above-described pressure differential effect may also be achieved.

The eighth aspect of the present invention provides a liquid transfer element, wherein the liquid transfer element can transfer the liquid in the first chamber to the second chamber. In some preferred forms, the pipetting element is capable of transferring the liquid in the fourth chamber towards the detection area.

In some preferred forms, the pipetting element comprises a first pipetting element for transferring a sample in the first chamber to the second chamber and a second pipetting element for transferring a sample in the fourth chamber to the detection area. In some preferred forms, the first pipetting element is movable under the influence of an external force so as to squeeze the sample in the first chamber, exerting a pressure thereon, causing it to be transferred in the desired direction or chamber. In some preferred forms, the second pipetting element is movable under the influence of an external force to squeeze the sample in the fourth chamber, exerting a pressure on it to transfer it in the desired direction or chamber.

In some preferred forms, the first pipetting element and the first chamber are in the same pipetting channel, and pushing the first pipetting element can effect the squeezing described above. In some preferred forms, the second pipetting element and the fourth chamber are in the same pipetting channel, and pushing the second pipetting element can effect the squeezing described above. In some preferred forms, the first pipetting element, the second pipetting element, the first chamber and the fourth chamber are in the same pipetting channel, and pushing one of the first pipetting element or the second pipetting element can simultaneously achieve the squeezing, in which case the first pipetting element and the second pipetting element can achieve a state of stepwise linkage, for example, in the case that the first pipetting element is pushed, the first pipetting element is first forced to move to squeeze the sample in the first chamber, the resistance to movement of the second pipetting element may be greater than the resistance to movement of the liquid in the first chamber, at which time the sample in the first chamber is preferentially transferred, and when the force of the sample in the first chamber being discharged to the first pipetting element on the second pipetting element is greater than the resistance to movement of the second pipetting element, the second pipetting element starts to squeeze the sample in the fourth chamber, so that the sample in the fourth chamber is also transferred, or, in other possible cases, the second pipetting element is pushed, the second pipetting element is forced to move first and squeezes the sample in the fourth chamber, in which case the resistance to movement of the first pipetting element may be greater than the resistance to movement of the liquid in the fourth chamber, the sample in the fourth chamber is preferentially transferred, and when the sample in the fourth chamber is discharged until the force of the second pipetting element on the first pipetting element is greater than the resistance to movement of the first pipetting element, the first pipetting element starts to squeeze the sample in the first chamber, so that the sample in the first chamber is also transferred. In some cases, it is desirable that the liquid in the first chamber is preferentially transferred when the first pipetting element and the second pipetting element are in linkage as described above.

In some preferred forms, the pipetting channel may be in fluid communication with or isolated from the second chamber. In some preferred embodiments, the pipetting channel can be in fluid communication with or isolated from the detection zone. In some preferred forms, the first pipetting element and the second pipetting element divide the pipetting channel into a first chamber and a fourth chamber. In some preferred forms, the second pipetting element separates the fourth chamber from the second chamber.

In some preferred forms, the volume of the first chamber is reduced when the sample in the first chamber is transferred to the second chamber. In some preferred forms, the first pipetting element and the second pipetting element are brought together when the volume of the first chamber is reduced. In some preferred forms, the volume of the fourth chamber is reduced when the sample in the fourth chamber is transferred to the test area. In some preferred modes, after the liquid in the first cavity is transferred, the liquid communication state between the first cavity and the second cavity is cut off. In some preferred forms, when the liquid in the fourth chamber is transferred, the liquid communication state between the fourth chamber and the third chamber is blocked. In some preferred modes, the communication state of the fourth cavity and the third cavity is isolated by the second pipetting element closing the second channel during the movement.

In some preferred modes, the initial volume of the fourth cavity is fixed, that is, the amount of the sample which can be filled in the fourth cavity can be determined before the fourth cavity is compressed under the force. In some preferred forms, the initial position of the second pipetting element within the pipetting channel is fixed. In some preferred forms, the initial volume of the first chamber is fixed, i.e. the amount of sample that can be loaded into the first chamber before the first chamber is forced to compress is determinable. In some preferred forms, the initial position of the first pipetting element within the pipetting channel is fixed. In some preferred forms, the first pipetting element and the second pipetting element are fixed in relation to the initial position within the pipetting channel.

In some preferred forms, the pipetting channel has a pipetting opening through which an external force can be applied into the pipetting channel to effect the above-described squeezing. In some preferred forms, the pipetting opening can be sealed by the first pipetting element or the second pipetting element. In some preferred forms, the pipetting element further comprises a pipetting plug capable of pushing the first pipetting element and/or the second pipetting element. In some preferred forms, the pipetting plug can project into the pipetting channel through the pipetting opening. In some preferred forms, the opening of the pipetting channel is in some preferred forms provided with a receptacle matching the pipetting plug on the first pipetting element and/or on the second pipetting element.

In some preferred forms, a sealing member is provided between the pipetting element and the pipetting channel to ensure that no sample can leak out from between the pipetting element and the inner wall of the pipetting channel when the pipetting element is moved in the pipetting channel.

The utility model discloses a ninth aspect, the utility model provides a method for collecting liquid sample, this method adopts as before the sample collection device, this sample collection device is including the first chamber that is used for collecting the liquid sample and the second chamber that is used for collecting the confirmation detection sample, and first chamber and second chamber can be in the state that liquid intercommunication or cut off, and when first chamber and second chamber were in the liquid intercommunication state, the liquid in the first chamber can be shifted to the second intracavity.

In some preferred embodiments, the kit further comprises a third chamber for collecting the sample, the third chamber and the first chamber can be in fluid communication with or separated from the first chamber, the collection of the initial sample can be performed through the third chamber, and the sample collected in the first chamber may be transferred to the second chamber for secondary detection.

In some preferred embodiments, when the first chamber and the third chamber are in fluid communication, the fluid collected in the third chamber can enter the first chamber at the same time, that is, when the third chamber performs the initial collection of the sample, the first chamber can be filled with the initially collected sample at the same time.

In some preferred modes, when the liquid in the first cavity is transferred into the second cavity, the first cavity and the third cavity are in a liquid separation state, and since the sample in the second cavity is used for secondary confirmation detection, in order to ensure that the sample in the second cavity is not polluted, the first cavity is separated from other cavities before the transfer.

In some preferred modes, the kit further comprises a fourth cavity for collecting the sample to be detected, and the fourth cavity can be in liquid communication or separated from the third cavity.

In some preferred modes, when the fourth chamber is in liquid communication with the third chamber, the liquid collected in the third chamber can enter the fourth chamber at the same time, and the fourth chamber can also be in communication with the third chamber at the time of initial sample collection, so that the fourth chamber can also complete the required sample substantially synchronously with the third chamber, the sample collected in the fourth chamber is mainly used for primary detection, and the primary detection can be performed directly in the fourth chamber or transferred to other areas, such as a detection area, through the fourth chamber.

In some preferred forms, the kit further comprises a detection region, the fourth chamber can be in fluid communication with or isolated from the detection region, and the fourth chamber can be isolated from the detection region when initially collected, i.e., collection and detection can be independent of each other.

In some preferred modes, when the fourth chamber and the detection area are in a liquid communication state, the fourth chamber and the third chamber are in a liquid separation state, so that on one hand, the detection area can be ensured not to be influenced by possible pollution caused by other chambers, on the other hand, quantitative detection can be realized, and the quantitative determination of a sample entering the detection area can be realized as long as the volume of the fourth chamber is set.

In some preferred forms, the second and third chambers can be combined or separated. In some preferred forms, the second chamber and the first chamber can be combined or separated. The second cavity is required to obtain the collected sample from the first cavity or the third cavity, so that the second cavity is required to be in liquid communication with the first cavity or the third cavity or one of the first cavity and the third cavity, and after the required sample is obtained, the second cavity is required to be capable of independently sealing and storing the cavity therein, even to be independently transported to a secondary detection mechanism, so that the second cavity is required to be separated from the first cavity or the third cavity or one of the first cavity and the third cavity, and in some preferred modes, the second cavity can be detachably combined with or connected with the first cavity or the third cavity or one of the first cavity and the third cavity.

In some preferred forms, the apparatus further comprises a communication means between the first and second chambers, the communication means providing a convenient channel and path for the sample in the first chamber to enter the second chamber.

In some preferred embodiments, the communicating means is not installed at the time of initial collection of the sample, and is installed again when secondary confirmation collection is required.

In some preferred modes, the communication device can enable the first cavity and the second cavity to be in a liquid communication state or can isolate the communication state of the first cavity and the second cavity.

In some preferred modes, the communication device can separate the communication state of the first cavity and the third cavity. After the initial sample is collected, the first chamber and the third chamber may be separated to ensure no contamination of the secondary confirmation sample.

The utility model discloses in, because the sample of initial collection can't enter into the second chamber naturally, must be through under certain exogenic action, under this condition, just must take certain effort to the sample of initial collection.

Thus, in some preferred forms, the method of the invention also provides a pipetting element, which, after the initial collection has been completed, is already filled with a sufficient quantity of sample, and then is pushed to squeeze the sample in the first chamber, either directly or through the communication means, into the second chamber, while at the same time the volume of the first chamber itself is compressed. In some preferred forms, the pipetting element may also transfer the sample in the fourth chamber. In some preferred forms, the transfer of the sample in the fourth chamber may be subsequent to the transfer of the sample in the first chamber. In some preferred forms, the first and fourth chambers may be squeezed with different pipetting elements, respectively. In some preferred forms, there may be a linkage between the pipetting elements of the first and fourth chambers.

In some preferred forms, the method of the present invention further provides a pipetting channel in which the pipetting element described above can be moved to squeeze the liquid in the first or fourth chamber. In some preferred forms, the first or fourth chamber may be a section of the pipetting channel separated by different pipetting elements to form a chamber. In some preferred forms, the first chamber may be in fluid communication with the second chamber. In some preferred forms, the fourth chamber may be in fluid communication with the detection zone. That is, the pipetting channel itself may communicate with the second chamber or the detection area or both.

In some preferred forms, the method of the present invention further provides a pipetting plug, which is mainly used for providing a moving power to the pipetting element to move the pipetting element in the pipetting channel so as to generate a squeezing force on the samples in the first cavity and/or the fourth cavity to transfer the samples.

In some preferred modes, the method of the present invention further provides a sealing structure between the pipetting element and the pipetting channel, so as to ensure that no gap is generated between the pipetting element and the inner wall of the pipetting channel when the pipetting element is forced to move, and no sample leakage occurs.

The tenth aspect of the present invention provides a method for detecting whether there is analyte in a liquid sample, wherein the detecting method includes the sample collecting device of any one of the above manners, and the sample to be detected is collected by the sample collecting device, and after the sample is collected in the fourth cavity, the sample therein is detected. In some preferred modes, after the sample is collected in the third cavity, the sample in the third cavity is detected. In some preferred modes, the sample in the fourth cavity is transferred to the detection area to be detected. In some preferred modes, the sample in the third cavity is transferred to the detection area to be detected. And (e) after obtaining the test result, separating the second chamber from the sample collection device in any of the manners described above.

The utility model has the advantages that: the structure of the utility model is characterized by simple and reasonable structure, low cost of the used materials and excellent performance; the secondary detection is convenient. Particularly, when subsequent confirmation detection is required, the whole detection device is not required to be sent to the testing mechanism for detection, but only the second cavity is taken out of the device and then sent to the detection structure, so that the detection device is safe, saves space and cost, and is more environment-friendly.

Drawings

FIG. 1 is a diagram showing the overall configuration of a sample detection device according to an embodiment.

FIG. 2 is a partial exploded view of the sample testing device in one embodiment, with the cover open and the pipette plug not inserted.

Fig. 3 is a schematic view of the cap in an embodiment when the second chamber and the communicator are assembled to the cap.

Fig. 4 is a schematic view of the cover shown in fig. 3 from another angle.

Fig. 5 is a structural view of the upper portion of the cover shown in fig. 3, showing the handle or knob structure assembled.

Fig. 6 is a schematic view of a cap in an embodiment where the second chamber is not yet assembled to the cap.

FIG. 7 is a diagram of the assembled relationship of the second chamber and mounting structure and the communicator in one embodiment.

FIG. 8 is a diagram illustrating the assembly of the second chamber and the communicating vessel in one embodiment.

FIG. 9 is a schematic view of a communicator in one embodiment.

FIG. 10 is a bottom view of a connector according to one embodiment.

FIG. 11 is a top view of a communicator in one embodiment.

FIG. 12 is a schematic view of a second chamber in one embodiment.

Fig. 13 is a schematic view from another angle of the second chamber shown in fig. 12, and from the angle of fig. 13 it can be seen that the bottom of the second chamber has an opening that enables the second chamber to be in fluid communication with the outside or other chamber.

Fig. 14 is a schematic view showing that the opening of the bottom of the second chamber shown in fig. 13 is sealed.

Fig. 15 is a schematic view of another angle of the second chamber shown in fig. 12. as can be seen in fig. 15, the second chamber can be collapsed to a flat condition when the second chamber is not loaded with a sample.

FIG. 16 is a schematic view of an assembled structure of a second chamber in an embodiment.

FIG. 17 is a schematic view of a second chamber in combination with a mounting structure in accordance with an embodiment.

Fig. 18 is a schematic view of the second chamber of fig. 17 after being loaded with a sample.

FIG. 19 is a schematic illustration of the second chamber being separated from the communicating vessel after sample collection is complete, in accordance with one embodiment.

FIG. 20 is a schematic diagram of a third chamber, which may be a cartridge, in one embodiment, where the detection zone may be located on one side of the third chamber.

FIG. 21 is a schematic view of the third chamber of FIG. 20 from another angle from which the first and second passages may be located.

FIG. 22 is a schematic view of the third chamber of FIG. 20 from another angle from which a partial configuration of the pipetting channels can be shown.

FIG. 23 is a schematic illustration of a third chamber in another embodiment having a sealing connection cover mounted thereon.

FIG. 24 is a schematic view of a sealing connection cap on the third chamber shown in FIG. 23.

Fig. 25 is a schematic view of another angle of the seal connection cap of fig. 24.

FIG. 26 is a sectional view of the third chamber in a specific embodiment, in the state shown in the figure, the first pipetting element and the second pipetting element are not yet mounted in the pipetting channel.

FIG. 27 is a cross-sectional view of the pipetting channel in an embodiment where the first and second pipetting elements are in a position when the device is not in use, where the first and fourth chambers are both compressed, the first channel is in fluid communication with the first chamber and the second channel is in fluid communication with the fourth chamber.

FIG. 28 is a sectional view of the pipetting channel in a specific embodiment, in the state shown in this figure the second pipetting element is moved in the direction of squeezing the fourth chamber and sealing of the second channel is started.

FIG. 29 is a cross-sectional view of the third chamber in one embodiment, shown in this view, with the first and second pipetting elements being advanced by the pipetting plug to an inward extreme position, in which the fourth chamber and the first chamber are both compressed, the sample in the fourth chamber is advanced into the detection zone, the sample in the first chamber is advanced into the second chamber, the first chamber and the first channel are in fluid isolation, and the fourth chamber and the second channel are in fluid isolation.

FIG. 30 is a schematic view of a pipette plug in one embodiment.

FIG. 31 is a schematic view of a first pipetting element in one embodiment.

FIG. 32 is a schematic view of the first pipetting element from another angle in one embodiment.

FIG. 33 is a schematic view of a second pipetting element in one embodiment.

Fig. 34 is a schematic view of the second pipetting element from another angle in one embodiment.

FIG. 35 is a schematic view of a sealing structure on the first pipetting element and the second pipetting element in one embodiment.

Fig. 36 is a schematic view showing an assembled relationship of the interconnector and the first passage.

FIG. 37 is a schematic view of the first chamber, the third chamber, and the communicator in one embodiment.

Reference numbers in the figures: a first chamber 41, a second chamber 42, a third chamber 43, a fourth chamber 44, a detection area 45, a detection inlet 46, a first channel 47, a second channel 48, a collection port 49, a collection tank 50, a pipetting channel 51, a first pipetting element 52, a second pipetting element 53, a detection inlet partition 54, an open end 55, an opening 56, a seal 57, a communicating vessel 58, a piercing element 59, a communicating chamber 60, a step surface 61, a second chamber mounting structure 62, a cover 63, a tapered surface 64, a test element inlet 65, a seal connection cover 66, a first cover 67, a second cover 68, the assembly structure comprises a connecting part 69 matched with the cover body, an assembly channel 70, an assembly structure outer wall 71, an assembly structure inner cavity 72, a hollowed-out structure 73, a fixing ring 74, an assembly connecting piece 75, a sealing element 76, a liquid transfer opening 77, a liquid transfer plug 78, a first moving cavity 79, a supporting leg 80, a sealing groove 81, a third channel 82 and a pressure hole 83.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings, and it should be noted that the embodiments are only for describing the present invention specifically, and should not be construed as limiting the present invention.

The structures referred to by the invention or the technical terms used therein will be further described first, and if not otherwise indicated, they will be understood and explained by the general technical terms commonly used in the art.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or a metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Confirmation detection

The confirmation test may also be referred to as a secondary test or a secondary confirmation test, and when the first test result shows that the test result may be positive or weakly positive or cannot be accurately judged, in order to ensure the accuracy of the test result or obtain a more accurate test result, the same batch of samples (most preferably collected in the same batch) needs to be sent to an off-site or remote site with the qualification of confirmation test for the second test, so as to verify the test result. The purpose of the confirmation test is to perform a confirmation operation on the field or the primary test result, the tested instrument can be more precise, and the testing method can be more rigorous, but the basic principle is the same as or similar to the primary test, and only the recheck is performed on the basis of the primary test.

Sample(s)

The sample that the detection device of the present invention can detect includes a biological fluid (e.g., a case fluid or a clinical sample). The liquid sample or liquid sample may be derived from solid or semi-solid samples, including fecal matter, biological tissue, and food samples. The solid or semi-solid sample may be converted to a liquid sample by any suitable method, such as mixing, triturating, macerating, incubating, dissolving, or enzymatically digesting a solid sample in a suitable solution (e.g., water, phosphate solution, or other buffered solution). "biological samples" include samples derived from animals, plants and food, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures, cell cultures and media of tissues and organs derived from humans or animals. Preferably the biological sample is urine. Food samples include food processing materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a waste liquid sample). Environmental samples may also include sewage or other wastewater.

By using the utility model and a suitable detection element, any analyte can be detected. Preferably utilizes the utility model discloses detect the drugs micromolecule in saliva, urine. Of course, utilize the utility model discloses a collection device can collect above any form sample, no matter be solid-state, still liquid, as long as these liquid or liquid sample flow into a certain cavity after, these liquid samples can flow into other cavities simultaneously or later, because other cavities can combine or separate with the cavity that flows in at first, when the initial sample of collecting, the cavity that flows in at first combines with other cavities, the collection of the liquid sample of a plurality of required cavities can be accomplished through once collecting the action to the user, when needing to carry out follow-up confirmation and detection, let certain cavity wherein separate with whole, thereby, the liquid sample in one of them cavity or a plurality of cavities can carry out the primary detection, and the liquid sample in the cavity that is separated out can carry out the secondary detection. Alternatively, the functional positions of the chambers may be interchanged, that is, the liquid sample in which chamber can be primarily detected and the liquid sample in which chamber can be secondarily detected may be interchanged.

Test element

The test element may be a lateral flow test strip which detects a plurality of analytes. Of course, other suitable test elements can be used in the present invention, and any element that can detect whether a sample or specimen contains an analyte of interest can be referred to as a test element, and such detection can be based on any of the technical principles, such as immunology, chemistry, electricity, optics, physics, and the like.

Various test elements may be combined and used in the present invention. One form is a test strip. Test strips for the analysis of analytes, such as drugs or metabolites indicative of a physical condition, in a sample may be in various forms, such as immunoassay or chemical assay forms. The test strip may be used in a non-competitive or competitive assay format. The test strip includes a bibulous material having a sample application area, a reagent area, and a test area. The sample is added to the sample application zone and flows by capillary action to the reagent zone. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for indicating the detection signal is present in the reagent zone or in a separate label zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains the analyte and no signal is generated if the analyte is not present. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The test element is a test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength when the test strip is held in place.

The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The signal-producing substance can be on the sample addition zone, reagent zone, or detection zone, or the entire test strip, and the substance can be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal substance was added was dried.

The various regions of the test strip may be arranged as follows: the device comprises a sample adding area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

A commonly used reagent strip is a nitrocellulose membrane reagent strip, i.e., a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display the detection result; and may be a cellulose acetate film, a nylon film, or the like. Such as the reagent strips or devices containing the reagent strips described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The test strip disclosed in the above patent documents and similar devices with test strips can be applied to the test element or the test device of the present invention for detecting an analyte, such as an analyte in a sample.

The test strips used in the present invention may be so-called Lateral flow test strips (Lateral flow test strips), and the specific structure and detection principle of these test strips are well known in the art. A typical test strip comprises a sample collection area comprising a sample receiving pad, a labeling area comprising a labeling pad, a detection area comprising a bibulous pad, and a bibulous area comprising a chemical reagent, such as an immunological reagent or an enzymatic reagent, necessary to detect the presence of the analyte. A commonly used detection reagent strip is a nitrocellulose membrane reagent strip, that is, a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display a detection result; it may be a cellulose acetate film, a nylon film, etc., and it may also include a detection result control region downstream of the detection region, and usually, the control region and the detection region are in the form of a transverse line, which is a detection line or a control line. Such test strips are conventional, but other types of test strips that utilize capillary action for testing are also contemplated. In addition, typically, the test strip has a dry chemical reagent component, such as an immobilized antibody or other reagent, which when exposed to a liquid, flows along the test strip by capillary action, and as it flows, the dry reagent component is dissolved in the liquid, and the next zone is processed to react the dry reagent in that zone, thereby performing the necessary test. The liquid flow is mainly by capillary action. These test elements are described and documented in the following documents: lefukang 'research on regeneration treatment of nitrocellulose membranes and protein adsorption capacity thereof'; malanhuang, Liqiang et al analysis of performance of chromatography material in colloidal gold diagnostic kit; wangyong, Wanglauca et al, a novel colloidal gold immunochromatographic test strip. The present invention can be applied to a detecting device, or can be disposed in a detecting chamber to contact with a liquid sample, or can be used to detect whether an analyte exists or the amount of the analyte exists in the liquid sample entering the detecting chamber.

In addition to the test element being in the form of a test strip, which itself is used to test whether a fluid sample contains an analyte in a larger chamber, such as the third chamber 43 of the present application, in some preferred embodiments, the test element may be disposed on a centralized test card having a plurality of grooves, the test element is disposed in the groove, the entire test card is disposed in the detection region 45, and the fluid sample entering the third chamber 43 can enter the detection region 45 through the detection inlet 46 due to the presence of the detection inlet 46 communicating the third chamber 43 with the detection region 45, and can be detected by the test element on the test card. Of course, in addition to the carriers disclosed above, additional carriers may be employed in the present invention as carriers for carrying test strips. For example, in some embodiments, the third chamber 43 or other chambers may be first filled with a liquid sample and then inserted into the third chamber 43 for testing using a separate test strip or a card or carrier with a test strip. It will be understood by those skilled in the art that the test strips may not be disposed on a carrier, but may be independent of each other, as described herein, and that the detection zone 45 of the present invention may be absent in some cases, as well as the test strips.

Flow of liquid

The liquid flow may also be referred to as a sample flow or a liquid sample flow, in some cases, the transfer of the sample is also realized by the flow, the liquid flow generally refers to a flow from one place to another place, generally, the natural liquid flow mostly depends on gravity from a high place to a low place, and the flow here also depends on an external force, i.e., the flow under the external gravity condition, and can be a natural gravity flow. In addition to gravity, the flow of liquid may also move from low to high against gravity. For example, the liquid may be drawn, or the liquid may be pressed, or the liquid may be pressurized to flow from a lower position to a higher position, or may be pressurized to flow against the gravity of the liquid itself.

For example, in fig. 27-29, the third chamber is located above the first chamber and the fourth chamber, and the fourth chamber is located below the third chamber, when liquid enters the third chamber, the liquid can naturally flow from the third chamber to the first chamber and the fourth chamber by gravity, or from upstream to downstream by gravity, and when the device is shaken as a whole, the liquid may change its flow direction due to the change of gravity direction.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs of abuse (e.g., drugs of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. Abuse of these drugs can result in physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americane, white amphetamine tablets, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep-aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofballs, barbs, blue devils, yellow jacks, hypnones); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline and doxepin); dimethyldioxymethylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine, or opiates, cocaine, COC; heroin, dihydrocodeinone); anxiolytic and sedative hypnotic, anxiolytic is a kind of mainly used for relieving anxiety, stress, fear, stabilize mood, have hypnotic sedative effects at the same time, including benzodiazepine BZO (benzodiazepines), atypical BZ, fuse dinitrogen NB23C, benzodiazepine, BZ receptor ligand, ring-opening BZ, diphenylmethane derivatives, piperazine carboxylate, piperidine carboxylate, quinazolone, thiazine and thiazole derivatives, other heterocycles, imidazole type sedative/analgesic (such as dihydrocodeinone OXY, methadone MTD), propylene glycol derivative-carbamate, aliphatic compound, anthracene derivatives, etc.. The detection device of the utility model can also be used for detecting the detection which belongs to the medical purpose and is easy to take excessive medicine, such as tricyclic antidepressants (imipramine or analogues) and acetaminophen, etc. After being absorbed by human body, the medicines are metabolized into small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

For example, analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial material (e.g., proteins or carbohydrate material directed against specific bacteria, such as, for example, Escherichia coli 0157: H7, staphylococci, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Cactus), and substances associated with physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can all utilize the cooperation of side direction crossing current detection form the utility model discloses the device detects.

Communication and/or isolation

In the present invention, the communication means a state of fluid communication, that is, in this structure, the fluid can go from one area to another area, or can go from one part of the structure to another part, or can go from the first cavity of the structure to another cavity, where "to" is realized by the fluidity of the fluid itself, and the communication specifically means fluid communication, that is, gas communication or liquid communication. By gas or liquid communication is meant that liquid or gas can flow from one place to another, possibly guided by some physical structure during the flow. By physical structures is generally meant that the liquid flows passively or actively to another place through the surface of the physical structures or the space inside the physical structures, and passively is generally a flow caused by external force, such as a flow under capillary action. The flow here can also be a liquid or a gas, because of its own effect (gravity or pressure), or a passive flow. Communication herein does not necessarily mean that a liquid or gas is required to be present, but merely that in some cases a connection or condition between two objects, if any, may flow from one object to the other. This refers to a state in which two objects are connected, and conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a state of non-communication, non-liquid or gas communication. In the present invention, sometimes, the state of such gas communication or liquid communication is also directly referred to as fluid communication or simply communication, and such communication does not require the actual presence of fluid (e.g., liquid or gas) in the structure, but only indicates that the structure is in such a state. Correspondingly, the partition in the present invention refers to a state opposite to the communication (fluid communication), that is, not communicated, that is, in the partition state, the fluid cannot realize the above-mentioned from one region to another region under the action of the fluidity, or can realize from one part to another part of the structure, or can realize from the first cavity to another cavity of the structure, and similarly, the partition does not need the actual liquid in the structure, and can be only one state of the structure.

Detection or collection device

The detection device is a device for detecting whether or not an analyte is contained in a sample. A collection device refers to a device that performs the collection and storage of a liquid sample. The detection means may comprise collecting means which may also comprise detection means, or the collecting means may be separate from the detection means, and the collecting means and the detection means may be combined at the time of detection, thereby completing the detection. The collection device and the detection device may be an integrated device, once the liquid sample is collected, the detection can be performed immediately to obtain the test result, and the separation of the detection sample and the collection sample is performed simultaneously, so that the secondary detection can be performed (if necessary). The meanings of the detection device or the detection cavity can be interchanged, and the collecting device and the collecting cavity can be interchanged, so that the functions are interchanged only by playing different roles. For example, when the collecting device is said in the present invention, the detecting chamber may not be included, but the collecting device may include the test element or the carrier containing the test element, and the collecting device containing the test element may also be referred to as a detecting device. Of course, the collecting device may comprise a space for arranging the test elements, but does not necessarily have to comprise test elements, which may subsequently be combined with the collecting device at any suitable time to form the detecting device. For example, the collecting device may comprise a space for accommodating a test element, e.g. containing the detection area 45, or a suitable position for arranging a test element or a carrier containing a test element in a liquid-collecting chamber of the collecting device.

First chamber for collecting liquid sample

In some embodiments of the present invention, as shown in fig. 27-29, the present invention provides a collecting device for collecting a liquid sample, or a detecting device for detecting a liquid sample, of course, the detecting device also has a collecting function or includes a collecting device, the collecting device or the detecting device includes a first cavity 41, the first cavity 41 can be used as a directly collecting cavity, and the collection of the sample can also be realized by other cavities, such as a third cavity 43.

When the first chamber 41 is used as a direct collection chamber, it may have an opening directly communicating with the outside, and a sample may be injected or loaded into the first chamber 41 through the opening, for example, in the structure shown in fig. 26, in which case the first chamber 41 may directly collect the sample from the outside. When the first chamber 41 is used to effect the collection of a sample by means of a further chamber, as shown in figures 27-29, which communicates directly with the third chamber 43 via a first passage 47, and the first chamber 41 is located below the third chamber 43, the third chamber 43 having an upwardly directed collection port 49, through the collection port 49, the liquid sample can enter the third chamber 43 and fall naturally or down under gravity, and the portion of the liquid sample that falls naturally and enters the first passage can fall directly into the first chamber 41, a portion of the liquid sample that is inevitably unable to fall directly into the first channel 47 during the natural fall, may accumulate at the bottom of the third chamber 43, when the liquid level exceeds the height from the first passage 47 above the bottom of the third chamber 43, the liquid flows into the first chamber 41 through the first passage 47.

In some preferred forms, for example, as can be seen in the figures, a collection groove 50 may be provided on the side wall of the first passage 47, and this collection groove 50 may be flush with the bottom of the third chamber 43 or slightly higher than the bottom of the third chamber, and the liquid sample that does not enter the first passage 47 during the natural falling process may eventually collect at the bottom of the third chamber 43, and since the collection groove is closer to the bottom of the third chamber 43, the liquid sample at the bottom of the third chamber 43 may enter the first passage 47 through the collection groove 50 and thus flow into the first chamber 41 along the first passage 47. It should be noted that, since it is not necessary for all of the sample in the third chamber 43 to flow into the first chamber 41, but only a part thereof, a part of the sample will inevitably enter the first passage 47 as long as the amount of the collected liquid is sufficient, and, in practical use, the whole chamber may be in a non-static state, for example, being held by hand, and the collected sample will be more likely to enter the collection tank 50 due to shaking.

In some preferred embodiments, the liquid sample in the first chamber 41 can be used directly for detection. In some preferred embodiments, the liquid sample in the third chamber 43 can be directly used for detection. In some preferred ways, the liquid sample in the first chamber 41 can be transferred to other chambers, such as the second chamber 42.

In some preferred forms, the volume of the first chamber 41 is variable, for example in the process shown in fig. 27-29, the first chamber 41 is actually a space in the pipetting channel 51, which space is formed by the first pipetting element 52 and the second pipetting element 53, and the volume of the first chamber 41 changes when the first pipetting element 52 or the second pipetting element 53 or both are moved in the pipetting channel 51. In some preferred forms, the volume of first chamber 41 may be compressed, at which time the liquid sample stored therein may be expressed, into another chamber, or for another purpose. In some preferred embodiments, the volume of the first chamber 41 may be increased, in which case the first chamber 41 may be attracted inwardly to collect more fluid sample more quickly, or in some preferred embodiments, the volume of the first chamber 41 may be increased as the amount of sample collected increases.

Self-sealing

The self-sealing means that when no other acting force acts on the cavity except for pressure which may be generated on the inner wall or the outer wall of the cavity by the cavity itself or an object (including liquid, gas and other substances) contained in the cavity, the cavity can be in a sealed state, and the inside of the cavity is in a state of fluid isolation from the outside or other cavities, so that fluid exchange (including liquid, gas and the like) cannot be allowed. In some cases, the self-sealing means that, in addition to the pressure that may be generated on the inner wall or the outer wall of the cavity by the cavity itself or an object (including liquid, gas, and other substances) contained in the cavity, even if a certain external force is applied to the inner wall or the outer wall of the cavity, the cavity is still in the above-mentioned sealed state as long as the external force is not large enough or does not reach a certain value. In some cases, there may be an opening or a punctured hole in the cavity, but due to the material adopted by the cavity or the relationship of a certain wall thickness, the opening or the punctured hole may also satisfy the condition that the cavity cannot be opened under the action of an internal force or an external force not large enough, and when the external force or the external force is large enough, the cavity can be in liquid communication with the outside or other cavities without intervention of other components (the opening or the punctured hole may be passed through), and after the external force is removed, the cavity can be restored to the original fluid isolation state, and we call the cavity as a self-sealing cavity.

Third chamber for collecting liquid sample

In some embodiments of the present invention, as shown in fig. 20-23, the present invention provides a collecting device for collecting a liquid sample, or a detecting device for detecting a liquid sample, of course, the detecting device also has a collecting function or includes a collecting device, the collecting device or the detecting device includes a third cavity 43, the third cavity 43 can be used as a directly collected cavity, and can also be used as a detected cavity, or the third cavity 43 can also be used as a temporarily stored cavity, so that a liquid sample entering the third cavity 43 enters other cavities through the third cavity 43, and other cavities can be collecting cavities or detecting cavities.

For example, in the embodiment shown in FIGS. 27-29, the third chamber 43 serves as a transition chamber for the first chamber 41 to collect the liquid sample, and in some ways as previously described, the first chamber 41 can simultaneously collect the liquid sample into the third chamber 43. Of course, the third chamber 43 may be used to collect the sample through other chambers.

When third chamber 43 is used as a transitional chamber, as shown in FIG. 21, the bottom of the third chamber may have a first channel 47 in fluid communication with first chamber 41 and a second channel 48 in fluid communication with fourth chamber 44. in this case, as long as first channel 47 and second channel 48 are not sealed, first chamber 41 and fourth chamber 44 may be able to collect the sample substantially simultaneously with third chamber 43.

In some preferred embodiments, the third chamber 43 can be in fluid communication with the detection region 45 through a detection inlet 46, and the detection inlet 46 can be adjusted or set to be in communication or isolated, so that the fluid in the third chamber 43 can be introduced into the detection region 45 as needed, and the detection region 45 can be provided with or without a test element. When the test element is arranged in the detection area, the detection area can be made of transparent materials for the convenience of observation.

In some preferred manners, a collecting groove 50 may be formed on a side wall of the first passage 47, the collecting groove 50 may be flush with the bottom of the third chamber 43 or slightly higher than the bottom of the third chamber, and a portion of the liquid sample that does not enter the first passage 47 during the natural falling process may eventually collect at the bottom of the third chamber 43, and due to the close height of the collecting groove and the bottom of the third chamber 43, the liquid sample at the bottom of the third chamber 43 may enter the first passage 47 through the collecting groove 50 and flow into the first chamber 41 along the first passage 47. It should be noted that, since it is not necessary for all of the sample in the third chamber 43 to flow into the first chamber 41, but only a part thereof, a part of the sample will inevitably enter the first passage 47 as long as the amount of the collected liquid is sufficient, and, in practical use, the whole chamber may be in a non-static state, for example, being held by hand, and the collected sample will be more likely to enter the collection tank 50 due to shaking.

In some preferred embodiments, the first chamber 41 and the third chamber 43 may be in a liquid-separated state at the time of initial collection, that is, the liquid sample collected by the third chamber 43 cannot enter the first chamber 41 automatically or directly enter the first chamber 41 under the action of the self-weight of the sample, for example, the communication relationship between the first chamber 41 and the third chamber 43 is separated by a certain element, and after a certain force is applied to the liquid sample in the third chamber 43, the separation of the element may be broken, so that the sample enters the first chamber 41 from the third chamber 43. That is, in this case, the first chamber 41 does not have to be a chamber for initially collecting the sample, and it may be a passage that provides a path for the sample to enter the second chamber 42 from the third chamber 43, and due to the path, the sample can directly enter the second chamber 42 without contaminating the outer wall of the second chamber 42.

In some preferred forms, the third chamber 43 may be sealed by a cover. In some preferred forms, the cover may be directly connected to the third chamber 43 to seal the third chamber. In some preferred forms, the cover may directly seal the third chamber including the detection region. In some preferred forms, the cap may be used to seal only the collection port of the third chamber. In some preferred forms, the cover may be connected to the cover by a sealing connection. For example, as shown in fig. 24-25, a sealing connection cover 66 can be used for sealing the collection port 49 and the test element inlet 65, the sealing connection cover 66 comprises a first cover 67 for covering the sample collection inlet and a second cover 68 for covering the test element inlet 65, the sealing connection cover 66 can simultaneously cover the collection port 49 and the test element inlet 65 through the first cover 67 and the second cover 68, the sealing connection cover 66 can be connected with the cover body again, or the sealing connection member itself is in a sealing state, and as shown in the figure, the first cover 67 and the second cover 68 are in snap fit with the opening of the third chamber and the detection region. In addition to the mode shown in the figure, the film can be used for hot plastic packaging, so long as the film is sealed and airtight or liquid-tight during detection, and after the detection is finished and the second cavity is separated from the device body, the device body (including the detection area) can be discarded without storing and transporting the whole detection device.

In some preferred embodiments, the sample is first loaded into third chamber 43 and not loaded into first chamber 41. In some preferred modes, the sample in the third chamber 43 can enter the first chamber 41 under the action of certain external force. For example, as shown in FIG. 37, in some preferred embodiments, the first chamber 41 can be provided with a third channel 82 through the third chamber 43, such that during initial collection, no sample can be loaded into this third channel 82. In some preferred forms, the second chamber 42 and the mounting structure for the second chamber may be mounted to the third passageway, and the same connector 58 may be used to connect the first and second chambers 42. In some preferred forms, the sample in the third chamber 43 may be forced under pressure from the first chamber 41 directly into the third channel 82. In some preferred forms, the second chamber 42 may be directly fitted to the third channel 82. In some preferred embodiments, the third channel 82 and the third chamber 43 have a common opening, but care is taken when loading the sample so that the sample does not enter the third channel 43. In some preferred forms, the third channel 43 may be closed, for example by a plug, or by a membrane, in case of initial collection of the sample.

In some preferred modes, the bottom of the third cavity is provided with openings which can be communicated with the first cavity, the openings can be opened under certain conditions, and the openings are communicated with the first cavity and the third cavity only and are not communicated with other cavities or the outside. In some preferred forms, the openings are provided in the bottom of the third chamber. In some preferred forms, the openings are provided in a wall common to the first and third chambers. In some preferred embodiments, the openings are pressure holes 83, and when sufficient pressure is applied to the third chamber 43, the pressure holes 83 are opened to allow the first chamber and the third chamber to be in fluid communication, so that the sample can directly enter the first chamber from the third chamber, and when the pressure is removed, the pressure holes 83 can be closed again. In some preferred forms, the pressure port may be a self-sealing port as previously described, such as a "Pop" like port. In some preferred forms, the pressure port is capable of withstanding the liquid pressure of the third chamber in the closed state, i.e. simply by loading the third chamber with samples which do not have sufficient weight to open the pressure port. In some preferred ways, the pressure port can be opened when a certain amount of sample is collected. In some preferred modes, the pressure which can be borne by the pressure hole can be configured according to actual needs. In one embodiment, the cross-section of the first chamber 41 is wider than the cross-section of the third channel 82, so that a distance is provided between the third channel 82 and the first chamber 41, at which distance the pressure port 83 is arranged. In some preferred modes, the pressure in the third chamber 43 may come from a cover body, for example, a piston on the cover body pushes or presses the upper liquid surface downwards, or the cover body can generate pressure when covering, and acts on the upper liquid surface.

Detection inlet

The detection inlet 46 is a communication port between the collection chamber and the detection zone, however, it is not necessary to communicate the detection zone with the collection chamber at all times, the collection chamber may be separated from the detection zone and communicated as desired, in which case, a detection inlet partition 54 may be provided at the detection inlet 46, and the detection inlet 46 may be adjusted or set to be communicated or partitioned by the detection inlet partition 54, so that the liquid in the third chamber 43 may be introduced into the detection zone 45 as desired.

For example, as shown in fig. 27, the detecting inlet partition 54 has a certain hardness and thickness, and is provided with a notch, and the cut surfaces of the notch are in interference fit, so that the whole notch is in a closed state under the condition of no pressure or insufficient pressure, and can block the liquid from flowing through, but when one side of the notch is subjected to pressure, the notch is opened along the direction of the pressure, and natural pressure relief is performed, that is, when one side of the notch has a certain amount of sample, or a certain pressure is applied to the sample, the notch can be flushed, so that the collecting cavity is in liquid communication with the detecting region 45, and when the pressure is removed, the notch can be restored to the closed state.

Detection area

The detection zone 45 is used in the present invention to analyze a liquid sample for the presence of an analyte. Generally, a test element may be included within the detection zone 45 that is in contact with the liquid sample to perform an assay or test on the liquid sample. In conventional products, it is common to manufacture devices with test chambers by first fabricating the test elements or by placing the test elements on a carrier, then inserting the test elements into the test areas, and then sealing the test areas. In this case, the detection area generally has an opening to allow the test element to enter and exit the detection area. As shown, for example, in fig. 1-2 and 20-21, the upper end of the test zone 45 is provided with a test element access opening 65, through which test element access opening 65 a test element can be inserted into the test zone 45, as previously described. Typically, the opening 65 of the test area needs to be sealed after insertion into the test chamber, which is very high in sealing effect and quality, and as explained above, the entire test device or collection device needs to be transported and packaged together, so that in order to avoid leakage of the liquid in the test area or in the third chamber, any place where leakage may occur needs to be tightly sealed, and each product needs to be tested for sealing, which increases the production cost. But adopt the utility model discloses a second chamber with secondary confirmation back, just can not need to consider with carelessness to these places that the former consideration needs sealed effectual, this kind of sealed only need temporary sealed just enough, need not require lasting sealed moreover. For example, as shown in fig. 24-25, a sealing connection cover 66 can be used for sealing the collection port 49 and the test element inlet 65, the sealing connection cover 66 comprises a first cover 67 for covering the sample collection inlet and a second cover 68 for covering the test element inlet 65, the sealing connection cover 66 can simultaneously cover the collection port 49 and the test element inlet 65 through the first cover 67 and the second cover 68, and the sealing of the sealing connection cover 66 can be realized by a conventional sealing, for example, the first cover 67 and the second cover 68 are snap-fitted into the opening of the third chamber and the detection region. In addition to the mode shown in the figure, the film can be used for hot plastic packaging, so long as the film is sealed and airtight or liquid-tight during detection, and after the detection is finished and the second cavity is separated from the device body, the device body (including the detection area) can be discarded without storing and transporting the whole detection device. In some preferred forms, the sealing connection cover 66 may also be provided with a connection portion 69 which is matched with the cover body as shown in fig. 24-25, in some preferred forms, the connection portion 69 may be a screw connection, such as the form shown in the figures, of course, the connection portion 69 may also be any other form of connection as long as the connection of the sealing connection cover 66 and the cover body 63 can be realized. Of course, the sealing cover 66 itself may be a cover of the apparatus, and in this case, the connecting portion 69 is not necessary, and the sealing cover 66 is directly formed in a shape capable of sealing the entire apparatus.

Second chamber for collecting confirmation test sample

In some embodiments of the present invention, a second chamber 42 for collecting confirmatory test samples is provided. In some preferred embodiments, the second chamber 42 is capable of collecting the same batch of sample as the initial test sample, i.e., the initial sample is collected and the same batch of sample is loaded into the second chamber 42. In some preferred forms, the sample in the second chamber 42 is from the first chamber 41. In some preferred forms, the sample in the second chamber 42 is from a third chamber 43. In some preferred forms, the second chamber 42 may collect the sample directly.

As a specific implementation of the second chamber, as shown in fig. 12-15, the second chamber 42 is a variable volume chamber having an open end 55, in some preferred embodiments, the open end 55 is not compressible, as shown in fig. 13, an opening is provided in the open end 55, the opening 56 may communicate with other chambers to collect samples through the other chambers, or the opening may allow the second chamber 42 to collect samples by itself. In some preferred forms, this opening 56 may be sealed by a seal 57, as shown in fig. 14, which seal 57 is capable of being fixedly attached, tightly fitted or removably attached or engaged with the opening 56 when sealed. In some preferred forms, the communication between the connector 58 and the second chamber 42 may be accomplished by a puncturing element 57.

In some preferred embodiments, the open end 55 may be compressible, in which case the open end may be formed integrally with the second chamber 42 without a separate seal, or a seal may be provided that is compressible along with the open end 55, where the seal may be required to have some flexibility or elasticity.

In some preferred embodiments, the second chamber 42 may have a self-sealing opening, which, as previously described, may be sealed under a range of pressures to ensure that the liquid in the second chamber 42 does not escape, but may open when the pressure exceeds a certain value and return to a sealed state when the pressure exceeding the certain value is removed.

In some preferred modes, sealing member 57 can be a rubber plug or a plastic plug or a silicone plug, and the material thereof has certain elasticity, and can be communicated with the outside or other cavities through a puncture element when being punctured, and can recover the sealing after the puncture element is removed, and the recovered sealing can ensure that the liquid therein cannot leak within a certain pressure range.

In some preferred embodiments, a vacuum may be drawn in the second chamber 42, so that the second chamber 42 may be evacuated to facilitate the flow of the sample into the second chamber 42 once it is in communication with other chambers or the outside.

In some preferred embodiments, second lumen 42 changes shape and volume after being filled with a liquid sample, as shown in FIGS. 18-19, and expands from a flat shape to a cylindrical shape when second lumen 42 is filled with a volume of liquid sample. Since the second chamber 42 has such flexibility or elasticity and the open end thereof is pierced by the piercing member when the sample is loaded, the sample loaded in the second chamber 42 can press the second chamber 42 to flow out from the pierced open end of the piercing member when it is needed for use.

In some preferred forms, the second chamber may also be a rigid chamber, for example made of glass or plastic material, and the seal 57 may be provided with an opening capable of self-sealing, for example, an opening resembling a "carafe". In some preferred forms, the self-sealing opening may be provided directly on the second lumen.

Communicating vessel

As shown in fig. 9-11, in some embodiments of the present invention, a communicating vessel 58 is provided for communicating the second chamber 42 with the first chamber 41. In some preferred forms, the connector 58 is removably connected or coupled to the second chamber 42. In some preferred modes, when the cavity and the communicating vessel are connected or combined, the communicating vessel can be used for communicating the interior of the cavity with other cavities or external liquid. In some preferred modes, when the cavity and the communicating vessel are disassembled, the cavity is in a self-sealing state. In some preferred forms, the communication device 58 is used to communicate the second chamber 42 with other chambers, such as the first chamber 41, or the third chamber 43. In some preferred forms, a communication device 58 is provided for communicating the second chamber 42 with the external space.

As shown in fig. 9, the communicating vessel 58 may have a puncturing element 59, and the puncturing element 59 may puncture the second chamber 42 under an external force and establish a communication path for the second chamber 42 to other chambers or the outside. In some preferred forms, the piercing element 59 is a needle as shown.

In some preferred forms, the communicating vessel 58 has a communicating chamber 60, the piercing member 59 communicates with the communicating chamber 60, and the communicating chamber 60 itself can communicate with other chambers, for example, the communicating chamber 60 can communicate with the first chamber 41, when the first chamber 41 is squeezed, the sample in the first chamber can enter the second chamber 42 along the piercing member 59 through the communicating chamber 60, and in some preferred forms, the communicating chamber 60 can also serve as an inlet for directly collecting the sample.

In some preferred embodiments, the communicating chamber 60 can receive a portion of the first passage 47, which includes, inter alia, the collection trough 50, as described above, and as shown in fig. 36, is an assembly of the communicating vessel and the first passage, in which the communicating vessel separates the first passage from the third passage 43, so that the first passage can only communicate with the second chamber 42 and the first chamber 41, and the second chamber 42 can only receive the sample from the first chamber 41, which is particularly suitable for use in the case where the sample in the other chambers is used for testing, so as to ensure that the sample entering the second chamber 42 for secondary testing is not contaminated during the initial testing, and that the outer periphery of the second chamber is not contaminated by the sample from the third chamber after the first passage is separated from the third chamber, and that the outer surface of the second chamber is not contaminated by the sample after the second chamber is collected and taken out.

In some preferred embodiments, a stop structure may be provided for the communicating vessel 58 and the cover 63, which stop structure may prevent the communicating vessel 58 from being carried away from the cover, because the outer wall of the communicating vessel 58 may contact the sample, in which case the communicating vessel 58 is preferably not carried away at the same time as the second chamber 42 when the second chamber 42 is removed, or the sample may be carried away, i.e., the second chamber 42 is removed while the second chamber 42 is separated from the communicating vessel 58, which separation may be achieved by the stop structure limiting the movement of the communicating vessel. In some preferred forms, the limiting structure may be provided on the cover 63. In some preferred forms, a stop structure may be provided on the connector 58.

In some preferred embodiments, the end surface of the communicating vessel 58 has a step surface 61, the step surface 61 can be used as a reference surface for covering the communicating vessel 58 on the first passage 47, and when the second chamber finishes collecting a sample, the communicating vessel 58 can be connected to the second chamber 42 due to the piercing element 59, and the second chamber and the communicating vessel 58 need to be separated, that is, a certain external force needs to be applied, but the communicating vessel itself is contaminated by the sample and cannot be operated manually, in this case, due to the protrusion of the step surface 61, the step surface 61 can be acted on by the fitting structure 62 of the second chamber on the cover 63, so that the communicating vessel 58 can be still left in the device and cannot be pulled out therewith when the second chamber 42 is separated. In addition, the adapter 58 has a tapered surface 64, the primary function of which is to facilitate installation of the adapter 58.

As shown in fig. 3-4, in one embodiment of the present invention, the connector 58 may be mounted to the cover 63 at the lower end of the mounting structure 62 of the second chamber during initial use, and then fit over the first channel 47 as the cover 63 is closed. The connector 58 does not connect to the second chamber during initial use or initial assembly, and the connector 58 will only connect to the second chamber under certain action when the sample for secondary confirmation detection needs to be collected.

For example, as shown in fig. 7-8 and 36, the communicating vessel 58 is not yet in communication with the second chamber 42, and no liquid sample is collected in the second chamber 42, in this engaged state, the piercing member 59 on the communicating vessel 58 can pierce the outer wall of the second chamber or the sealing member 57 on the second chamber to be in liquid communication with the second chamber by pushing the communicating vessel 58 toward the second chamber 42 through the engagement relationship or external force. Also as shown in fig. 19, it is understood that the connector 58 is pulled out of the second chamber, and a sufficient amount of the liquid sample has been collected in the second chamber, and the connector 58 is pulled out, and the punctured outer wall of the second chamber or the seal 57 of the second chamber can be naturally closed, and the naturally closed state can withstand the pressure of the liquid sample collected in the second chamber. When it is desired to use, the second chamber is squeezed and the liquid sample can flow from the punctured site.

Cover body

As shown in fig. 3-6, in some embodiments of the present invention, the present invention provides a cover 63, and in some preferred embodiments, as shown in fig. 2, the cover 63 can be connected to the sealing connection cover 66, and the cover 63 and the sealing connection cover 66 can be detachably combined or connected through the connection portion 69, that is, the cover 63 can be covered on the sealing connection cover 66 and can be removed therefrom. In some preferred modes, the sealing connection cover 66 may not be provided, the cover 63 directly covers the mouth of the third cavity 43, the cover 63 may also be detachably combined with or connected to the mouth of the third cavity 43, and when the cover 63 covers, the whole sample collection device of the present invention can be sealed. As mentioned above, the seal may be a common seal or a seal with higher requirements, and is selected according to actual requirements.

In some preferred embodiments of the present invention, the cover 63 can enclose the second chamber 42 while being sealed and fitted, so that the second chamber 42 is located at a position or state where a sample can be collected at any time. Of course, the present invention does not exclude that in some preferred embodiments, the second cavity 42 may be placed in a position or state where the sample can be collected at any time in other manners. In some preferred modes, set up the assembly structure 62 of second chamber on the lid 63, second chamber 42 can be with this assembly structure 62 detachable connection or combine the utility model discloses a device is used (for example when transportation storage or sale) second chamber 42 can separate with assembly structure 62, if this separation can reduce the utility model discloses the shared space of overall structure, then when using, pack into assembly structure 62 with second chamber 42 again in, the second chamber can be packed into suitable position along with assembly structure. In some preferred embodiments, the cover 63 is provided with a mounting channel 70, and the mounting structure 62 of the second chamber is detachably coupled or connected to the mounting channel 70, i.e., the second chamber can be first assembled into the mounting structure and then assembled into the cover 63 through the mounting structure.

In some preferred embodiments, the communication device 58 is also received in the mounting structure 62, but the receiving of the communication device 58 in the mounting structure 62 does not mean that the communication device is in direct communication with the second chamber 42. as previously described, the communication device 58 may be in fluid communication with or separate from the second chamber 42 under other cooperative or external forces as desired for the application.

Assembly structure of second chamber

In some preferred modes of the present invention, the present invention provides an assembly structure 62 of a second chamber, wherein the assembly structure 62 mainly functions to pack the second chamber into the second chamber, in some preferred modes of the present invention, the second chamber 42 is a flexible body, the outer wall of which can be squeezed, and the second chamber needs to be detachably combined or connected with a cover or other chambers, and certain external force is inevitably applied to the second chamber in the detachable combining or connecting process, if there is no external protection structure for the flexible body of the second chamber, it is very possible that the force is not applied properly to extrude the liquid sample therein, which is an absolute condition to be avoided, therefore, the assembly structure not only bears the second chamber, but also plays a role of supporting and temporary protection for the second chamber.

In some preferred forms, the second cavity may also be a rigid cavity, such as made of glass or plastic material, in which case the assembly structure may also provide some protection to the second cavity, and more particularly, provide a convenient way to grasp and hold the second cavity.

In some preferred forms, as shown in figures 7, 16-17, the mounting structure has an outer wall 71 and an inner cavity 72 into which the second chamber can be fitted, and the second chamber and the inner cavity can be mounted together in a fixed, fixed or removable combination. The purpose of the assembly is to enable the second chamber and the assembly structure to be connected or integrated as a unit with the cover or other chambers and components. As mentioned above, the mounting structure 62 needs to support and protect the second cavity, and therefore, the outer wall of the mounting structure 62 must have a shape and hardness, which exceeds the outline shape of the second cavity, and the hardness is sufficient to withstand a certain pressure without causing squeezing of the second cavity, such as squeezing of fingers.

In some preferred modes, since the second cavity may be realized by pressing the outer wall of the second cavity when releasing the sample, the outer wall of the assembly structure is provided with a plurality of hollow structures 73, and the second cavity can be pressed through the hollow structures 73. In some preferred modes, due to the existence of the hollow-out structure 73, the assembling structure can bear extrusion deformation within a certain range, and when the sample needs to be released, the purpose of discharging the sample can be achieved as long as the assembling structure is extruded and the assembling structure applies pressure to the second cavity.

In some preferred forms, mounting structure 62 is provided with a retaining ring 74 that mates with open end 55 of the second chamber, and the outer wall of open end 55 is fixedly attached, bonded, or removably attached or bonded to the inner wall of retaining ring 74 to secure the second chamber to the mounting structure. In some preferred forms, retaining ring 74 and open end 55 are both located at the lower end of the second chamber and mounting structure.

In some preferred forms, the mounting structure 62 is removably coupled or connected to the cover 63. In some preferred embodiments, the mounting structure 62 is provided with a mounting connector 75, the mounting connector 75 can be detachably coupled or connected with the cover, in some preferred embodiments, the mounting connector 75 is detachably coupled or connected with the cover 63 through a screw, and in other preferred embodiments, the mounting connector 75 can be connected with the cover through other detachable connection methods.

In some preferred embodiments, for the convenience of the second chamber, as shown in fig. 16-17, the assembly structure 62 is provided with a knob 76, as shown in fig. 1-3, after the assembly structure is assembled on the cover 63, the knob 76 is exposed on the outer surface of the cover, and the assembly structure and the second chamber can be taken out by rotating the knob 76 in the opposite direction, it should be noted that the knob 76 is only one possible implementation manner, and in fact, the specific implementation forms of the handle, the pick, the ring, and the like can achieve this function as long as there is an element exposed on the outer surface of the cover to facilitate the assembly and the disassembly of the second chamber, and the invention is not limited to the specific form of this element.

In some preferred forms, the seal 57 of the second chamber may be fixed to the mounting structure 62, for example, at the fixing ring 74, or outside the fixing ring 74, or at another location through the seal 57 that allows communication with the interior of the second chamber 42.

First channel

In some preferred forms, the first chamber of the present invention does not have an outward collection port directly, but receives the liquid sample through another chamber, such as the third chamber 43, in which case the first chamber and the third chamber are in fluid communication. In some preferred forms, the first chamber and the third chamber are in direct communication. In some preferred forms, the first and third chambers are in fluid communication via a first passage 47, as shown in fig. 27-29, the first passage 47 serving to place the first and third chambers in fluid communication, and through which fluid can pass from the third chamber into the first chamber. For example, in the manner shown, this first passage 47 is located at the bottom of the third chamber 43, so that the sample entering the third chamber can naturally flow into the first chamber under the effect of its own weight. The first channel 47 is directly communicated with the third chamber 43, the first chamber 41 is located below the third chamber 43, the third chamber 43 has an upward collecting port 49, through the collecting port 49, the liquid sample can enter the third chamber 43 and naturally fall or flow downwards under the action of gravity, the part of the liquid sample which naturally falls and enters the first channel can directly fall into the first chamber 41, and a part of the liquid sample cannot necessarily directly fall into the first channel 47 in the natural falling process, so that the part of the liquid sample can be accumulated at the bottom of the third chamber 43, and when the liquid level exceeds the height from the first channel 47 to the bottom of the third chamber 43, the part of the liquid can flow into the first chamber 41 through the first channel 47. In some preferred forms, the sample may also pass from the first chamber into the third chamber.

In some preferred forms, for example, as can be seen in the figures, a collection groove 50 may be provided on the side wall of the first passage 47, and this collection groove 50 may be flush with the bottom of the third chamber 43 or slightly higher than the bottom of the third chamber, and the liquid sample that does not enter the first passage 47 during the natural falling process may eventually collect at the bottom of the third chamber 43, and since the collection groove is closer to the bottom of the third chamber 43, the liquid sample at the bottom of the third chamber 43 may enter the first passage 47 through the collection groove 50 and thus flow into the first chamber 41 along the first passage 47. It should be noted that, since it is not necessary for all of the sample in the third chamber 43 to flow into the first chamber 41, but only a part thereof, a part of the sample will inevitably enter the first passage 47 as long as the amount of the collected liquid is sufficient, and, in practical use, the whole chamber may be in a non-static state, for example, being held by hand, and the collected sample will be more likely to enter the collection tank 50 due to shaking.

In some preferred embodiments, the first channel 47 may be closed, for example, when the sample in the first chamber is transferred to the second chamber, or when the second chamber is taken out and put in, since the second chamber is used for collecting the liquid sample for the secondary confirmation detection, when the first channel is closed, the first chamber and the third chamber are in a liquid-separated state, for example, in some preferred embodiments, the sample first enters the third chamber and can flow into the first chamber along the first channel, the liquid in the first chamber can enter the second chamber under the action of external force, and in some preferred embodiments, when the first chamber and the second chamber are in a liquid-connected state, the first channel can be closed. In some preferred embodiments, as shown in fig. 36, the first channel may be closed by a communicating vessel, and in this assembled mode, the communicating vessel separates the first channel from the third chamber 43, so that the first channel can only communicate with the second chamber 42 and the first chamber 41, and the second chamber 42 can only receive the sample from the first chamber 41, which is particularly suitable for the case where the sample in the other chambers is used for detection, and it is ensured that the sample entering the second chamber 42 for secondary detection is not contaminated during the initial detection, and after the first channel is separated from the third chamber, the outer periphery of the second chamber is not contaminated by the sample from the third chamber, and after the second chamber is completely collected and taken out, the outer surface of the second chamber is not contaminated by the sample.

The fourth chamber

In some preferred forms, the present invention provides a fourth chamber for temporarily storing a test sample, as shown in fig. 27-28, wherein the sample in the fourth chamber is primarily used for primary testing. In some preferred modes, the sample is detected directly from the fourth chamber. In some preferred modes, the sample in the fourth cavity is pushed into the detection area for detection. In some preferred forms, the fourth chamber may collect the sample directly. In some preferred forms, the fourth chamber may collect the sample via another chamber.

When the fourth chamber is used to collect a sample via the other chambers, in some preferred forms the fourth chamber can be in fluid communication or isolated from the third chamber. In some preferred embodiments, when the fourth chamber is in fluid communication with the third chamber, the fluid collected in the third chamber can simultaneously enter the fourth chamber, and the fourth chamber can also be in fluid communication with the third chamber at the time of initial collection of the sample, for example, as shown in fig. 27-28, the fourth chamber is located at the bottom of the third chamber, and the bottom of the third chamber is provided with an opening in communication with the fourth chamber, so that the fluid sample entering the third chamber can directly flow into the fourth chamber under the action of gravity, and the fourth chamber can also complete the desired sample substantially simultaneously with the third chamber. In some preferred modes, the fourth chamber can be directly communicated with the third chamber. In some preferred forms, the fourth chamber may be in fluid communication with the third chamber via a second passageway.

In some preferred embodiments, the fourth chamber can be in fluid communication with or isolated from the detection region, and the fourth chamber can be isolated from the detection region when the fourth chamber is initially collected, i.e., the collection and detection can be separate entities. In some preferred forms, the isolation and communication between the fourth chamber and the detection zone may be achieved by a detection inlet. As previously described, the detection inlet 46 is a communication port between the collection chamber and the detection zone, however, it is not necessary to communicate the detection zone with the collection chamber at all times, the collection chamber may be separated from the detection zone and communicated as desired, in which case a detection inlet partition 54 may be provided at the detection inlet 46, and the function that the detection inlet 46 may be adjusted or set to communicate or partition is achieved by the detection inlet partition 54, so that the liquid in the third chamber 43 may be introduced into the detection zone 45 as desired.

For example, as shown in fig. 27, the detecting inlet partition 54 has a certain hardness and thickness, and is provided with a notch, and the cut surfaces of the notch are in interference fit, so that the whole notch is in a closed state under the condition of no pressure or insufficient pressure, and can block the liquid from flowing through, but when one side of the notch is subjected to pressure, the notch is opened along the direction of the pressure, and natural pressure relief is performed, that is, when one side of the notch has a certain amount of sample, or a certain pressure is applied to the sample, the notch can be flushed, so that the collecting cavity is in liquid communication with the detecting region 45, and when the pressure is removed, the notch can be restored to the closed state.

In some preferred modes, when the fourth cavity 44 is in liquid communication with the detection region 45, the fourth cavity 44 and the third cavity 43 are in liquid separation, so that on one hand, the detection region is not affected by possible contamination of other cavities, and on the other hand, quantitative detection can be realized, and the quantitative determination of the sample entering the detection region can be realized as long as the volume of the fourth cavity is set.

The second channel

As previously described, the second channel 48 is provided to place the fourth chamber 44 in fluid communication with the third chamber 43, thereby allowing the fourth chamber 44 to collect a sample simultaneously with the third chamber 43. In some preferred embodiments, the second channel is also closed when the sample in the fourth chamber is transferred to the detection zone, considering that the sample itself is free from contamination, the sample in the other chamber is free from contact during the detection, and the sample does not flow back after contacting the test element in the detection zone. For example, in the state shown in FIG. 28, the initial position of the second pipetting element 53 is located on the lower side of the second channel 48, the position of the second channel is not changed during the collection of the sample in the fourth chamber 44, and when it is necessary to push the sample into the detection area, the second pipetting element 53 is moved in the direction to approach the detection area 45, and this is also a process of gradually closing the second channel 48. In some preferred forms, the distance between the second channel 48 and the detection area is smaller than the length of the second pipetting element 53 itself, so that after pipetting has been completed, the second channel 48 is still closed by the second pipetting element 53.

First and second pipetting elementsLiquid element, pipetting channel and pipetting plug

The utility model provides a move liquid element, move liquid element's effect makes the liquid in first chamber 41 shift to second chamber 42 internal transfer. In some preferred forms, the pipetting element is also capable of transferring the liquid in the fourth chamber 44 towards the detection area 45, both transfers being synchronized or separate processes.

In some preferred forms, as shown in fig. 27-29 and 31-34, the pipetting element comprises a first pipetting element 52 for transferring the sample in the first chamber 41 to the second chamber 42 and a second pipetting element 53 for transferring the sample in the fourth chamber 44 to the detection area 45, the first pipetting element 52 and the second pipetting element 53 can be moved independently or in combination, and the first pipetting element 52 and the second pipetting element 53 are typically pushed to move and then generate a pushing force on the liquid in the respective chambers to transfer the samples to other chambers or areas. For example, the first pipetting element 52 can be moved by an external force to squeeze the sample in the first chamber 51, pressurizing it and transferring it in the desired direction or chamber, for example through the communication 58 into the second chamber. In some preferred forms, the second pipetting element 53 is movable under the influence of an external force to squeeze the sample in the fourth chamber 44, exerting a pressure thereon to displace it in the desired direction or chamber, for example into the detection zone 45.

In some preferred forms, the first pipetting element 52 and the first chamber 41 are in the same pipetting channel 51, and pushing the first pipetting element can effect the squeezing described above. In some preferred forms, the second pipetting element and the fourth chamber are in the same pipetting channel, and pushing the second pipetting element can effect the squeezing described above. In some preferred forms, the first pipetting element, the second pipetting element, the first chamber and the fourth chamber are located in the same pipetting channel 51, pushing one of the first pipetting element or the second pipetting element can simultaneously achieve the squeezing described above, in which case the first pipetting element and the second pipetting element can achieve a state of stepwise linkage, for example, in the case that the first pipetting element is pushed, the first pipetting element is first forced to move to squeeze the sample in the first chamber, the resistance to movement of the second pipetting element may be greater than the resistance to movement of the liquid in the first chamber, at which time the sample in the first chamber is preferentially transferred, when the force of the sample in the first chamber being discharged to the first pipetting element on the second pipetting element is greater than the resistance to movement of the second pipetting element, the second pipetting element starts to squeeze the sample in the fourth chamber, so that the sample in the fourth chamber is also transferred, or, in other possible cases, the second pipetting element is pushed, the second pipetting element is forced to move first and squeezes the sample in the fourth chamber, in which case the resistance to movement of the first pipetting element may be greater than the resistance to movement of the liquid in the fourth chamber, the sample in the fourth chamber is preferentially transferred, and when the sample in the fourth chamber is discharged until the force of the second pipetting element on the first pipetting element is greater than the resistance to movement of the first pipetting element, the first pipetting element starts to squeeze the sample in the first chamber, so that the sample in the first chamber is also transferred. In some cases, it is desirable that when the first pipetting element and the second pipetting element are in linkage as described above, the liquid in the first chamber is preferentially transferred, and then the liquid in the fourth chamber breaks through the entrance of the detection area, so as to ensure that the liquid sample transferred into the second chamber in the first chamber is not contaminated during detection.

In some preferred forms, the pipetting channel may be in fluid communication with or isolated from the second chamber. In some preferred embodiments, the pipetting channel can be in fluid communication with or isolated from the detection zone. In some preferred forms, the first pipetting element and the second pipetting element divide the pipetting channel into a first chamber and a fourth chamber. In some preferred forms the second pipetting element separates the fourth chamber from the second chamber, and in fact, as can also be seen in the figures, in some preferred forms the first chamber and the fourth chamber are two segments on the pipetting channel.

In some preferred forms, the volume of the first chamber is reduced when the sample in the first chamber is transferred to the second chamber. In some preferred forms, the first pipetting element and the second pipetting element are brought together when the volume of the first chamber is reduced. In some preferred forms, the volume of the fourth chamber is reduced when the sample in the fourth chamber is transferred to the test area. In some preferred modes, after the liquid in the first cavity is transferred, the liquid communication state between the first cavity and the second cavity is cut off. In some preferred forms, when the liquid in the fourth chamber is transferred, the liquid communication state between the fourth chamber and the third chamber is blocked. In some preferred modes, the communication state of the fourth cavity and the third cavity is isolated by the second pipetting element closing the second channel during the movement.

The utility model has the other characteristic that the quantitative detection can be realized. For example, in some preferred embodiments, the initial volume of the fourth chamber is fixed, i.e., the amount of sample that can be loaded into the fourth chamber is determinable before the fourth chamber is forced to compress. In some preferred forms, the initial position of the second pipetting element within the pipetting channel is fixed. In some preferred forms, the initial volume of the first chamber is fixed, i.e. the amount of sample that can be loaded into the first chamber before the first chamber is forced to compress is determinable. In some preferred forms, the initial position of the first pipetting element within the pipetting channel is fixed. In some preferred forms, the first pipetting element and the second pipetting element are fixed in relation to the initial position within the pipetting channel.

In some preferred forms, the pipetting channel has a pipetting opening 77 through which an external force can be applied to the pipetting channel to effect the above-described squeezing. In some preferred forms, the pipetting opening can be sealed by the first pipetting element or the second pipetting element. In some preferred forms, the pipetting element further comprises a pipetting plug capable of pushing the first pipetting element and/or the second pipetting element. In some preferred forms, the pipetting plug can project into the pipetting channel through the pipetting opening. In some preferred forms, the opening of the pipetting channel is in some preferred forms provided with a receptacle matching the pipetting plug on the first pipetting element and/or on the second pipetting element.

In some preferred embodiments, a sealing member 76 is provided between the pipetting element and the pipetting channel 51, and the sealing member 76 can be a sealing ring as shown in fig. 35, which can be made of a material with certain elasticity to ensure that no sample can leak from between the pipetting element and the inner wall of the pipetting channel when the pipetting element moves in the pipetting channel. A further function of the sealing member 76 is to increase the friction between the pipetting member and the inner wall of the pipetting channel, so that a quantitative collection and a quantitative detection can be achieved with sufficient friction that the liquid introduced into the first and fourth chambers is not sufficient to displace the pipetting member.

As shown in fig. 31-32, in one embodiment, the first pipetting element 52 comprises a first moving chamber 79, and a power member such as a pipetting plug 78 can be partially inserted into the moving chamber 79 to push the first pipetting element 52. correspondingly, the pipetting plug 78 can also be provided with a taper, and the taper can provide a point of application for the power member, and can also define the direction of pushing to some extent. In some preferred forms, the first moving chamber 79 may not be provided. In some preferred embodiments, the first pipetting element 52 is provided with a support foot 80, and the support foot 80 can separate the first pipetting element 52 from the second pipetting element 53, ensuring that a certain space is always left between the two pipetting elements. In some preferred embodiments, the first pipetting element may also be provided without support legs. In some preferred embodiments, a sealing groove 81 is provided on the first pipetting element, and the sealing element 76 is mounted in the sealing groove 81. Sealing groove 81 may be one or more grooves.

In a specific embodiment, as shown in FIGS. 33-34, the second pipetting element 53 comprises a second moving chamber 82, and the power member can partially extend into the moving chamber 82 to push the second pipetting element 53, so as to push the sample in the fourth chamber into the detection area, as shown in FIG. 29, in a state where the sample in the fourth chamber is completely pushed into the detection area. In some preferred forms, the second moving chamber 82 may not be provided.

Method for collecting liquid sample

The utility model provides a method of collecting liquid sample, this method adopt as before the sample collection device, this sample collection device is including the first chamber that is used for collecting the liquid sample and the second chamber that is used for collecting the confirmation detection sample, and first chamber and second chamber can be in the state of liquid intercommunication or wall, and when first chamber and second chamber were in the liquid intercommunication state, the liquid in the first chamber can be shifted to in the second chamber.

In some preferred embodiments, the kit further comprises a third chamber for collecting the sample, the third chamber and the first chamber can be in fluid communication with or separated from the first chamber, the collection of the initial sample can be performed through the third chamber, and the sample collected in the first chamber may be transferred to the second chamber for secondary detection.

In some preferred embodiments, when the first chamber and the third chamber are in fluid communication, the fluid collected in the third chamber can enter the first chamber at the same time, that is, when the third chamber performs the initial collection of the sample, the first chamber can be filled with the initially collected sample at the same time.

In some preferred modes, when the liquid in the first cavity is transferred into the second cavity, the first cavity and the third cavity are in a liquid separation state, and since the sample in the second cavity is used for secondary confirmation detection, in order to ensure that the sample in the second cavity is not polluted, the first cavity is separated from other cavities before the transfer.

In some preferred modes, the kit further comprises a fourth cavity for collecting the sample to be detected, and the fourth cavity can be in liquid communication or separated from the third cavity.

In some preferred modes, when the fourth chamber is in liquid communication with the third chamber, the liquid collected in the third chamber can enter the fourth chamber at the same time, and the fourth chamber can also be in communication with the third chamber at the time of initial sample collection, so that the fourth chamber can also complete the required sample substantially synchronously with the third chamber, the sample collected in the fourth chamber is mainly used for primary detection, and the primary detection can be performed directly in the fourth chamber or transferred to other areas, such as a detection area, through the fourth chamber.

In some preferred forms, the kit further comprises a detection region, the fourth chamber can be in fluid communication with or isolated from the detection region, and the fourth chamber can be isolated from the detection region when initially collected, i.e., collection and detection can be independent of each other.

In some preferred modes, when the fourth chamber and the detection area are in a liquid communication state, the fourth chamber and the third chamber are in a liquid separation state, so that on one hand, the detection area can be ensured not to be influenced by possible pollution caused by other chambers, on the other hand, quantitative detection can be realized, and the quantitative determination of a sample entering the detection area can be realized as long as the volume of the fourth chamber is set.

In some preferred forms, the second and third chambers can be combined or separated. In some preferred forms, the second chamber and the first chamber can be combined or separated. The second cavity is required to obtain the collected sample from the first cavity or the third cavity, so that the second cavity is required to be in liquid communication with the first cavity or the third cavity or one of the first cavity and the third cavity, and after the required sample is obtained, the second cavity is required to be capable of independently sealing and storing the cavity therein, even to be independently transported to a secondary detection mechanism, so that the second cavity is required to be separated from the first cavity or the third cavity or one of the first cavity and the third cavity, and in some preferred modes, the second cavity can be detachably combined with or connected with the first cavity or the third cavity or one of the first cavity and the third cavity.

In some preferred forms, the apparatus further comprises a communication means between the first and second chambers, the communication means providing a convenient channel and path for the sample in the first chamber to enter the second chamber.

In some preferred embodiments, the communicating means is not installed at the time of initial collection of the sample, and is installed again when secondary confirmation collection is required.

In some preferred modes, the communication device can enable the first cavity and the second cavity to be in a liquid communication state or can isolate the communication state of the first cavity and the second cavity.

In some preferred modes, the communication device can separate the communication state of the first cavity and the third cavity. After the initial sample is collected, the first chamber and the third chamber may be separated to ensure no contamination of the secondary confirmation sample.

The utility model discloses in, because the sample of initial collection can't enter into the second chamber naturally, must be through under certain exogenic action, under this condition, just must take certain effort to the sample of initial collection.

Thus, in some preferred forms, the method of the invention also provides a pipetting element, which, after the initial collection has been completed, is already filled with a sufficient quantity of sample, and then is pushed to squeeze the sample in the first chamber, either directly or through the communication means, into the second chamber, while at the same time the volume of the first chamber itself is compressed. In some preferred forms, the pipetting element may also transfer the sample in the fourth chamber. In some preferred forms, the transfer of the sample in the fourth chamber may be subsequent to the transfer of the sample in the first chamber. In some preferred forms, the first and fourth chambers may be squeezed with different pipetting elements, respectively. In some preferred forms, there may be a linkage between the pipetting elements of the first and fourth chambers.

In some preferred forms, the method of the present invention further provides a pipetting channel in which the pipetting element described above can be moved to squeeze the liquid in the first or fourth chamber. In some preferred forms, the first or fourth chamber may be a section of the pipetting channel separated by different pipetting elements to form a chamber. In some preferred forms, the first chamber may be in fluid communication with the second chamber. In some preferred forms, the fourth chamber may be in fluid communication with the detection zone. That is, the pipetting channel itself may communicate with the second chamber or the detection area or both.

In some preferred forms, the method of the present invention further provides a pipetting plug, which is mainly used for providing a moving power to the pipetting element to move the pipetting element in the pipetting channel so as to generate a squeezing force on the samples in the first cavity and/or the fourth cavity to transfer the samples.

In some preferred modes, the method of the present invention further provides a sealing structure between the pipetting element and the pipetting channel, so as to ensure that no gap is generated between the pipetting element and the inner wall of the pipetting channel when the pipetting element is forced to move, and no sample leakage occurs.

Sample detection method

The utility model provides a method for whether there is analyzed matter in detection liquid sample, detection method includes the sample collection device of foretell arbitrary mode, collects the sample that waits to detect through the sample collection device, treats that the fourth intracavity has collected the sample after, detects sample wherein. In some preferred modes, after the sample is collected in the third cavity, the sample in the third cavity is detected. In some preferred modes, the sample in the fourth cavity is transferred to the detection area to be detected. In some preferred modes, the sample in the third cavity is transferred to the detection area to be detected. And (e) after obtaining the test result, separating the second chamber from the sample collection device in any of the manners described above.

One specific embodiment

As shown in FIG. 2, the sample collection device of the present invention may include a cover 63 and a third chamber 43, which are detachably connected by a connection portion 69. The sample collection device may further include components that may be individually unassembled prior to use, such as the second chamber 42, the mounting structure 62, the adapter 58, the pipette plug 78, etc., that may be loaded into the third chamber 43 during shipping and packaging, and a plug that may be pre-positioned in the mounting channel of the cover 63 to plug the mounting channel to prevent dust accumulation or contamination of the interior of the mounting channel. In some cases, the connector 58 may also be provided as a component that is assembled to the cover during use. In use, the plug is removed, the second chamber 42 is assembled into the assembly channel of the cap 63, the second chamber itself can be mounted on an assembly structure, the assembly structure and the second chamber form an assembly body, the assembly body is loaded into the assembly channel of the cap 63, the communicating vessel 58 is then loaded into the lower end of the assembly channel 70, the lower end of the assembly channel can be sealed by the communicating vessel 58, and before use, as shown in fig. 36, the communicating vessel 58 does not puncture the second chamber. In some cases, the communicator 58 may be pre-assembled at the bottom of the assembly channel of the cover 62, but not assembled to the mating limit.

When collecting the sample, the cover body is opened, the components such as the second cavity and the like are assembled in the cover body according to the relation, then the sample is collected in the third cavity, the sample can automatically flow into the first cavity and the fourth cavity until reaching the required amount, then the cover body 63 is closed, in the process of sealing the cover body, the communicating vessel 58 firstly seals the first channel, then the cover body is continuously closed downwards, the assembly channel is pressed downwards, so that the communicating vessel further enters the assembly channel until the sealing member 57 on the second cavity is punctured, at the moment, the first channel is sealed by the communicating vessel, the first cavity and the third cavity are in a separated state, the first cavity and the second cavity are in a liquid communication state through the communicating vessel, but because the communicating vessel is connected through the needle head, the liquid in the first cavity is positioned below the second cavity, the liquid in the first cavity can not actively flow into the second cavity, the sample in the fourth chamber does not actively flow into the detection region.

When the sample is detected, the first pipetting element 52 is pushed inwards by the pipetting plug 78, and the volume of the first chamber 41 is reduced by the inward movement of the first pipetting element 52, so that the liquid sample in the first chamber is squeezed and moved towards the second chamber, while also generating an inward pushing force on the second pipetting element 53, but before this inward pushing force overcomes the frictional resistance between the second pipetting element 53 and the inner wall of the pipetting channel 51, the second pipetting element 53 is stationary until the first pipetting element 52 and the second pipetting element 53 are in contact, at which point the second chamber has substantially completed collecting the sample, the pipetting plug is pushed further inward, the second pipetting element 53 starts to squeeze the liquid sample in the fourth chamber, pushing it into the detection area, the test is performed by the test element in a state shown at 29 in which the sample in the fourth chamber is pushed completely into the test area. Since the position of the second pipetting element 51 is determinable in the initial state, the volume of the fourth chamber 44 is determinable, thereby enabling quantitative detection.

In the mode of this embodiment, can place the test element in the detection zone, come to carry out initial detection to the sample through the test element, the detection zone adopts transparent material to make, can direct observation test result through the surface in detection zone, under the test result probably is positive or weak positive or can't confirm the condition, when needing to carry out the secondary and confirm the detection, through rotating knob 76, take out second chamber and assembly structure, the linker is stayed detection device this moment, the second chamber can independently be transported to the secondary and confirm detection mechanism and detect.

Claims (6)

1. A cup body for collecting samples is characterized by comprising a third cavity and a liquid transferring channel, wherein the third cavity and the liquid transferring channel can be in a liquid communication or separation state, the samples collected in the third cavity can naturally flow into the liquid transferring channel, or the samples collected in the third cavity can be transferred into the liquid transferring channel under the action of external force;

the pipetting channel is positioned below the third cavity, the cup body comprises a first channel for enabling the pipetting channel to be in liquid communication with the third cavity, the first channel is positioned at the bottom of the third cavity, and the first channel can be closed or opened;

a collecting groove is formed in the side wall of the first channel, and the collecting groove is flush with the bottom of the third cavity or slightly higher than the bottom of the third cavity; the collecting gutter can be closed off separately or simultaneously with the first channel;

the bottom of the third chamber has a first channel in fluid communication with the first chamber and a second channel in fluid communication with the fourth chamber.

2. The cup for collecting a sample of claim 1, wherein the cup includes a second channel for placing the pipetting channel in fluid communication with a third chamber.

3. The cup for collecting a sample of claim 2, wherein the second channel can be closed or opened.

4. The cup for collecting a sample of claim 1, comprising a detection zone;

a second chamber for collecting a confirmation test sample, and an assembly structure for the second chamber, the assembly structure being capable of housing the second chamber therein;

the sample transferring device further comprises a first pipetting element for transferring the sample in the first cavity into the second cavity and a second pipetting element for transferring the sample in the fourth cavity into the detection area, wherein the first pipetting element can move under the action of external force so as to press the sample in the first cavity into the second cavity through the communicating vessel.

5. A cup for collecting a sample according to claim 4, including a test inlet for placing the pipetting channel in fluid communication with the test area.

6. The cup for collecting a sample according to claim 4, wherein the liquid in the pipetting channel is capable of entering the detection area by an external force.

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