CN208721699U - A kind of collecting chamber of sample - Google Patents
A kind of collecting chamber of sample Download PDFInfo
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- CN208721699U CN208721699U CN201821071379.5U CN201821071379U CN208721699U CN 208721699 U CN208721699 U CN 208721699U CN 201821071379 U CN201821071379 U CN 201821071379U CN 208721699 U CN208721699 U CN 208721699U
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- chamber
- sample
- liquid
- intracavitary
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Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The utility model provides a kind of collecting chamber of sample, and including the third chamber for initial collection sample, third bottom of chamber portion, which is equipped with, can be naturally flowed by first passage intracavitary to first with the first passage of the first chamber fluid connection, the sample of the intracavitary collection of third.The collection well can separate the sample being collected into, and separate the sample for needing the sample for carrying out secondary-confirmation detection and initial detecting, can be independent sealed and be sent to testing agency and carry out confirmation detection.
Description
Technical field
The utility model relates to collect collection and detection liquid in the device of liquid sample, especially quick diagnosis field
The device of analyte in sample, such as urine collecting and detection device.
Background technique
Currently, for detect in sample whether the detection device containing analyte, be largely used to hospital or family
In, these detection devices for being applied to quick diagnosis include one or more detection reagent items, for example early pregnancy detects, drug abuse
Detection etc..The detection device of this quick diagnosis is very convenient, can be at one minute, or at most ten minutes or so are detecting
Testing result is obtained on reagent strip.
Illicit drugs inspection is widely used, be usually used in prohibition of drug department, public security bureau, narcotic house, medical center, country conscription physical examination at
Etc. mechanisms.Illicit drugs inspection wide variety, number is frequent, can be automatically separated the illicit drugs inspection urine cup of remaining sample Yu detected sample
With the huge market demand, after detection is completed, sample in urine cup will be by for illicit drugs inspection urine cup currently on the market
To detection reagent pollution and cannot continue on for second of confirmation detection, such as United States Patent (USP) 7300633 describe as.
Although detected sample in the conventional technology, can be allowed to be isolated with the sample of collection, cost
Height, and do not allow easy to operate.Such as United States Patent (USP), the piston urine cup that the patent No. 7300633 describes, when the mistake for pushing piston to advance
Cheng Zhong, allows liquid sample in collecting chamber, such as urine, is transferred to test chamber from collecting chamber, there is test sample in test chamber
The testing element of middle analyte, and the liquid sample of collecting chamber is kept apart by piston, so that two local samples are not
It can obscure, be detected so as to be used to later confirmation.Although can isolate out the sample of detection and the sample of collection in this way,
Be this piston urine cup it is at high cost, and operation is not easy, and pushes piston to need bigger strength after all, this is because living
Plug needs to reach transfer sample, is necessarily required to play the effect of hydraulic seal with the wall of piston, achievees the effect that sealing needs allow
Piston and plunger shaft closely combine.
For another example United States Patent (USP) 8992855 describes a kind of device for collecting liquid sample, which includes connecting with lid
The piston structure for being integrated and moving together with lid separates although can detecte sample and the sample of collection, when detection
It after sample enters test chamber, needs to overcome very big pressure just to can enter, and needs the size of sophisticated design lid and rim of a cup,
The piston being linked together in this way with lid can accurately be just inserted into disengagement chamber.
In addition, carrying out confirmation inspection if necessary to subsequent after the completion of the preliminary tests such as these traditional collections and detection device
It surveys, needing an entire collection and detection device to be transported to, the progress of confirmation testing agency is further to confirm detection, this just brings
Many problems, at least have a problem in that first, and major part liquid is collected at present and detection device is provided only with Preliminary detection
Chamber.When if necessary to subsequent confirmation detection, the whole device containing urine and detection reagent item can only be sent to confirmation detection machine
Structure is detected.Sample in urine cup is possible to the pollution by detection reagent.Second, whole device is sent to confirmation detection
When mechanism, since rim of a cup is larger, liquid has the risk of leakage during transportation, this is just needed more at allowing device to have originally
There is better seal effect, to reduce the risk of leakage to the greatest extent;Third, by whole device be transported to confirmation testing agency it
Afterwards, confirmation testing agency needs huge low temperature warehouse to store entire detection device, prevents liquid sample rotten, in order to it is subsequent can
Energy further confirms that detection is prepared, and confirmation testing agency (being properly termed as secondary detection mechanism) cost is caused substantially to rise in this way
It is high.
It for above-mentioned some technical problems, therefore needs to make improvements, other approach is provided and solves existing traditional skill
The deficiency of art.
Utility model content
For above situation, to overcome the shortcomings of existing technologies, the technical problem to be solved by the utility model is to provide
A kind of collecting chamber of sample, the collection well can separate the sample being collected into, and make to need to carry out secondary-confirmation inspection
The sample of survey and the sample of initial detecting separate, and can be independent sealed and be sent to testing agency and carry out confirmation detection.This
Utility model can will be collected into sample and assign in different chambers, and different chambers can be according to collection, separation or detection
Needs realize that part is connected to or partition, sample and can store needed for obtaining secondary detection respectively by once collecting,
Confirming will not pollute between the sample of detection and the sample and testing element of initial detecting, it is ensured that will not influence secondary true
The effect recognized.
In order to solve the above technical problems, the utility model the following technical schemes are provided:
A kind of collecting chamber of sample, including the third chamber for initial collection sample, third bottom of chamber portion is equipped with can be with the
The sample of the first passage of one chamber fluid connection, the intracavitary collection of third can be naturally flowed by first passage to the first chamber
It is interior.
Further, first passage is located at the bottom of third chamber.
Further, first passage can be closed or open.
Further, the side wall of first passage is equipped with a collecting tank, this collecting tank is flushed with the bottom of third chamber
Or the bottom of slightly above third chamber.
Further, collecting tank can individually be closed or with first passage while being closed.
It further, further include the 4th chamber for collecting sample to be detected, the 4th chamber can be in liquid with third chamber
The state of connection or partition.
Further, the sample of the intracavitary collection of third can naturally flow into intracavitary to the 4th, alternatively, the intracavitary collection of third
Sample can be flowed into the 4th under certain external force intracavitary.
Further, cavity includes the second channel for making the 4th chamber and third chamber fluid connection.
Further, second channel can be closed or open.
Further, including pipetting channel and liquid relief element.
Further, a part in pipetting channel is divided into the first chamber by liquid relief element.
Further, liquid relief element can move to change the volume of the first chamber in pipetting channel.
Further, liquid relief element can apply active force to the first intracavitary sample to turn the first intracavitary sample
Move on to other cavitys or outside.
Further, liquid relief element the first intracavitary sample can be applied active force to by the first intracavitary sample from
First passage is transferred to other cavitys or outside.
Further, when sample is shifted from first passage, first passage is isolated with third chamber.
Further, liquid relief element includes the first liquid relief element and the second liquid relief element, and the first liquid relief element and second move
Pipetting channel is isolated into the first chamber and the 4th chamber by liquid element.
Further, the first liquid relief element and the second liquid relief element can move in pipetting channel.
Further, the first chamber can be compressed when the first liquid relief element is mobile, turns liquid therein by first passage
It moves.
Further, the 4th chamber can be compressed when the second liquid relief element is mobile.
Further, while the second liquid relief four chamber of compression element, second channel is closed.
Following technical scheme also belongs to the content of the utility model:
The utility model in a first aspect, the utility model provides a kind of sample testing apparatus, including for collecting liquid
First chamber of sample and the second chamber for collecting confirmation detection sample, the first chamber and the second chamber be at fluid connection or every
Disconnected state, when the first chamber and the second chamber are in fluid connection state, the first intracavitary liquid can under external force by
It is intracavitary to be transferred to second.
In some preferred modes, external force can be gravity.In some preferred modes, external force is in addition to weight
Other active forces other than power.In some preferred modes, other active forces in addition to gravity, comprising contact and/or
Contactless pressure, thrust, extruding force etc..In some preferred modes, external force can be the active force for overcoming gravity.
In some preferred modes, external force can be the other active forces overcome other than gravity, for example, break through some obturator or
Person is open by some.In some preferred modes, external force may be power caused by inside configuration.In some preferred sides
In formula, external force can be certain power formed by structure or cooperation in inside configuration, such as push caused by pressure difference
Attraction caused by power or negative pressure or vacuum.In some preferred modes, vacuum can be set by the second chamber,
First chamber and the second chamber can be in the case where fluid connections, and liquid may will flow to second from the first chamber due to the effect of pressure difference
Chamber.In some preferred modes, the second chamber is not necessarily intended to perfect vacuum, as long as making the internal pressure of the second chamber less than the first chamber,
Above-mentioned differential pressure action may be implemented.In some preferred modes, the first chamber can be pressurized, also be can be realized above-mentioned
Differential pressure action.
In some preferred modes, the first chamber can be directly collected into sample or the first chamber can be with other chamber
Room connection is to directly or indirectly receive sample, and either directly still indirect reception, this reception mode are all not required to
External force is wanted to assist, for example, directly there is the first chamber the opening that can receive sample or the first chamber to have one and its
He directly receives the opening of the cavity fluid connection of sample, and sample can slide into first by other chambers under the effect of gravity
Chamber, this process can be realized naturally by the process collected, and not need auxiliary external force.
In some preferred modes, under no external force, between the first chamber and the second chamber be in liquid every
Disconnected state, that is to say, that be not no fluid connection in this case, between the first chamber and the second chamber;And it is outer being applied with
In the case that power acts on, fluid connection may be implemented between the second chamber and the first chamber, realize that liquid connects in the first chamber and the second chamber
In the state of logical, it is intracavitary that the first intracavitary sample can be transferred to second under pressure, that is to say, that first is intracavitary
Sample to be transferred to second it is intracavitary have to apply certain external force, this process can not pass through natural power (such as gravity)
It realizes, after the second chamber is collected into the sample suitably measured, removes external force, the first chamber and the second chamber can be restored to liquid again
The state of body partition.In some preferred modes, so that the first chamber and the second chamber is realized the external force of fluid connection state and make the
One intracavitary sample can be the same external force to the external force of the second intracavitary transfer, in some preferred modes, make the first chamber
The external force of fluid connection state is realized with the second chamber and can be the first intracavitary sample not to the external force of the second intracavitary transfer
Same external force.
There is the opening for leading to the second chamber as a kind of possible implementation, such as the first chamber, this opening tool
Have normally closed in the case where the not being pressurized and openable feature that is pressurized, in this way, the first intracavitary liquid being collected by
It in the case where pressure, can be entered by this opening second intracavitary, when pressure is removed, this opening restores closure again,
The first intracavitary sample is completed to the second intracavitary transfer.
As a kind of possible implementation, a linker can be set between the second chamber and the first chamber, this connection
The inside of first chamber and the second chamber can be connected in the case where (such as receiving pressure) by device under certain conditions, so that first
Chamber and the second chamber realize fluid connection, and in this case, the first intracavitary sample can be transferred to the second intracavitary, transfer completion
Afterwards, linker can be removed, the second chamber is closed.
As a kind of possible implementation, this linker can have one and puncture mouth, and the second chamber is close with one
Sealing, seal can puncture mouth by this and puncture, and after linker removes, it is close that this seal can restore liquid again
Envelope is sealed for example, by using rubber material, this punctures mouth can be pierced into seal under external force, make the first chamber and the second chamber
Connection, the first intracavitary liquid can puncture mouth in the case where compression by this, and to enter second intracavitary.
The second aspect of the utility model, the utility model provide be used for initial collection sample third chamber, third chamber and
First chamber can be in the state of fluid connection or partition with the first chamber.
In some preferred modes, third chamber can be in the state of nature fluid connection with the first chamber, that is to say, that
The intracavitary liquid of third can be naturally flowed under the action of not needing external force it is intracavitary to first, in some preferred modes
In, it is intracavitary that the first intracavitary liquid can also naturally flow into third under the action of not needing external force.
In some preferred modes, third chamber and the first chamber are in the state of fluid connection under external force, also
To say, the intracavitary fluid of third will not actively be flowed into it is first intracavitary, need to apply certain external force just and may be implemented fluid from
Flowing of the third chamber to the first chamber.In some preferred modes, it is intracavitary that the first intracavitary fluid will not actively flow into third, needs
Apply certain external force just and fluid may be implemented from the first chamber to the flowing of third chamber.
In some preferred modes, third chamber and the first chamber are in liquid partition state, that is to say, that first is intracavitary
Liquid can not be flowed into that third is intracavitary, and the intracavitary liquid of third can not also be flowed into first intracavitary, and the state of this partition can be with
Broken by external force, that is to say, that in some possible situations, can be realized between the first chamber and third chamber by external force
Fluid connection state.For example, in initial collection sample, third is intracavitary to be first collected into sample in some preferred modes
This, it is intracavitary that sample will not enter first in the case where no active force.
In some preferred modes, third chamber can be used as the cavity of initial collection sample, as described in preceding first aspect,
First chamber or third chamber can be used as the cavity of initial collection sample, and liquid company also may be implemented between the first chamber and third chamber
Logical, the liquid sample of so intracavitary collection of third can be flowed into first intracavitary, the first intracavitary sample collection of realization.
In some preferred modes, with the first passage of fluid connection between the first chamber and third chamber, fluid can be with
Enter third chamber from the first chamber by the first passage or enters the first chamber from third chamber.In some preferred modes, this
A first passage is located at the bottom of third chamber, in this way, entering the intracavitary sample of third can under the effect of gravity certainly
It is intracavitary to be so flowed into first.
In some preferred modes, the first passage between the first chamber and third chamber can be closed, and work as first passage
When being closed, the first chamber and third chamber are in liquid partition state, for example, sample initially enters in some preferred modes
Third chamber, and the first chamber can be flowed into along first passage above-mentioned, the first intracavitary liquid can enter the under external force
Two is intracavitary, and in some preferred modes, when the first chamber and the second chamber are in the state of fluid connection, first passage can be sealed
It closes.
In some preferred modes, the first chamber is located at the bottom of third chamber, when the first chamber and third chamber fluid communication,
It is intracavitary that the intracavitary liquid of third can be fed directly to first under Gravitative Loads.
In some preferred modes, the intracavitary fluid of third can not be flowed into naturally under the effect of gravity it is first intracavitary,
For example, the first chamber and third chamber are separated in its natural state, the first chamber and third chamber could be only opened under a certain pressure
Communication port, in such case, third is intracavitary to be preferentially packed into sample, then under pressure, such as cover cap close
Generated extruding force, the intracavitary sample of third can be pressed down against, and it is intracavitary to be forced into first.
In some preferred modes, third is intracavitary to be preferentially loaded into sample.Third is intracavitary in some preferred modes
Sample can enter under the action of certain external force it is first intracavitary.
In some preferred modes, the third channel for passing through third chamber is can be set in the first chamber, in initial collection
When, sample will not be loaded into some preferred modes in this third channel, the assembling structure of the second chamber and the second chamber
It can be assembled on third channel.In some preferred modes, the second chamber can be directly assembled on third channel.Some
In preferred mode, third channel and third chamber have shared opening, but when being loaded into sample, being will be slightly note that just not
Sample can be allowed to enter in third channel.In some preferred modes, when initial collection sample, third channel can be sealed
It closes, such as is clogged with plug, or sealed with film.
In some preferred modes, some apertures that can be connected to the first chamber are arranged in the bottom of third chamber.Some excellent
In the mode of choosing, it is connected between the first chamber and third chamber by pressure port, when third is intracavitary to be under pressure, pressure port is opened,
Fluid directly can enter the first chamber from third chamber, and when pressure is removed, pressure port can restore closure again.Some preferred
In mode, pressure port in closed state, is able to bear the fluid pressure for carrying out third chamber under state of filling, that is to say, that only
It is only to the intracavitary loading sample of third, the self weight of these samples is not enough to open pressure port.In some preferred modes, in sample
When originally reaching certain collecting amount, pressure port can be opened.In some preferred modes, the pressure that pressure port can bear can
To configure according to actual needs.
The third aspect of the utility model, the utility model provide the 4th chamber for collecting sample to be detected, the 4th chamber
The state of fluid connection or partition can be in third chamber.
In some preferred modes, third chamber can be in the state of nature fluid connection with the 4th chamber, that is to say, that
The intracavitary liquid of third can be naturally flowed under the action of not needing external force it is intracavitary to the 4th, in some preferred modes
In, it is intracavitary that the 4th intracavitary liquid can also naturally flow into third under the action of not needing external force.
In some preferred modes, third chamber and the 4th chamber are in the state of fluid connection under external force, also
To say, the intracavitary fluid of third will not actively be flowed into it is the 4th intracavitary, need to apply certain external force just and may be implemented fluid from
Flowing of the third chamber to the 4th chamber.In some preferred modes, it is intracavitary that the 4th intracavitary fluid will not actively flow into third, needs
Apply certain external force just and flowing of the fluid from the 4th chamber to third chamber may be implemented.
In some preferred modes, third chamber and the 4th chamber are in liquid partition state, that is to say, that first is intracavitary
Liquid can not be flowed into that third is intracavitary, and the intracavitary liquid of third can not also be flowed into the 4th intracavitary, and the state of this partition can be with
Broken by external force, that is to say, that in some possible situations, can be realized between the 4th chamber and third chamber by external force
Fluid connection state.
In some preferred modes, as described in preceding second aspect, third chamber can be used as the chamber of initial collection sample
Body, also may be implemented fluid connection between the 4th chamber and third chamber, the liquid sample of so intracavitary collection of third can be flowed into
4th is intracavitary, realizes the 4th intracavitary sample collection.
In some preferred modes, with the second channel of fluid connection between the 4th chamber and third chamber, fluid can be with
Enter the 4th chamber from third chamber by the second channel or enters third chamber from the 4th chamber.In some preferred modes, this
A second channel is located at the bottom of third chamber, in this way, entering the intracavitary sample of third can under the effect of gravity certainly
It is intracavitary to be so flowed into the 4th.
In some preferred modes, the second channel between the 4th chamber and third chamber can be closed, and work as second channel
When being closed, the 4th chamber and third chamber are in liquid partition state, for example, sample initially enters in some preferred modes
Third chamber, and the 4th chamber can be flowed into along second channel above-mentioned, the 4th intracavitary liquid can enter inspection under external force
It surveys in region, in some preferred modes, when the 4th chamber and detection zone are in the state of fluid connection, second channel can be with
It is closed.
5th aspect of the utility model, the utility model are provided for covering the lid for closing sample collection mouth.Some excellent
In the mode of choosing, lid can be used as the sealing element of whole device.In some preferred modes, lid can cover conjunction in sample
On the sample collection mouth of this collection device.
As previously mentioned, the second chamber can be in the state of fluid connection with the first chamber, then between the second chamber and the first chamber
Have a position and matching relationship.In some preferred modes, the second chamber and the first chamber can in conjunction with or and separate.?
In some preferred modes, the second chamber and third chamber can be combined or be separated.
In some preferred modes, the second chamber is assemblied on lid.In some preferred modes, the second chamber and lid
Removable connection.In some preferred modes, lid is equipped with the assembly channel of the second chamber.In some preferred modes,
Second chamber and the assembly removable connection in channel.In some preferred modes, assembly channel can be closed.
In some preferred modes, lid can be assembled on third chamber.In some preferred modes, when lid with
When third chamber lid is closed, the second chamber realizes fluid connection with the first chamber therewith.In some preferred modes, when lid and third chamber
When lid closes, linker, which punctures the second chamber, makes the first chamber and the second chamber realize fluid connection.In some preferred modes, work as lid
When closing with third chamber lid, assembly channel is closed in conjunction with first passage and by first passage, and third chamber and the first chamber is made to be in liquid
Body separates state.
In some preferred modes, lid can be assembled on the first chamber.In some preferred modes, when lid with
When first chamber lid is closed, the second chamber realizes fluid connection with the first chamber therewith.In some preferred modes, when lid and the first chamber
When lid closes, linker, which punctures the second chamber, makes the first chamber and the second chamber realize fluid connection.
5th aspect of the utility model, the utility model provide a kind of assembling structure of second chamber, and assembling structure can
Cooperate with intracorporal channel is covered, the second chamber is packed into lid or is taken out.In some preferred modes, assembling structure with
Lid removable combination or connection.In some preferred modes, removable combination is to be threadedly coupled.Some preferred
In mode, removable combination is mating.
In some preferred modes, assembling structure can be fixed wherein by the second chamber.In some preferred modes, dress
Distribution structure has one convenient for the assembling structure and lid is combined or isolated handle element.In some preferred modes
In, assembling structure has one convenient for the assembling structure and lid is combined or isolated knob element.Either handle
Element or knob element, effect are provided to that assembling structure and lid is made to be combined or separate.Some excellent
In the mode of choosing, after assembling structure and lid separation, lid can be clogged with plug.In some preferred modes, filling
Before distribution structure and lid assembly, lid can be clogged with plug, prevent from falling into ash for accommodating the space of assembling structure in lid
Dirt is contaminated.
In some preferred modes, assembling structure is equipped with some engraved structures, can by the part of these hollow outs
Apply certain external force to the second chamber, such as squeeze, flows out sample therein.
6th aspect of the utility model, the utility model provide a kind of linker, linker for be connected to the first chamber or
The second chamber of person makes to realize fluid connection between the first chamber and the second chamber.In some preferred modes, linker itself
With a chamber (connection chamber can be referred to as).In some preferred modes, linker when being connected to the first chamber,
Internal chamber and the first chamber fluid connection.In some preferred modes, linker is when being connected to the second chamber, linker
Internal connection chamber and the second chamber fluid connection.In some preferred modes, connection chamber and the first chamber inside linker with
And the second equal fluid connection of chamber.
In some preferred modes, linker can be combined or be separated with the second chamber.In some preferred modes,
Linker in a manner of puncturing the second chamber with the second chamber fluid connection.In some preferred modes, linker and the second chamber point
From rear, the second chamber Natural closure.In some preferred modes, linker and the removable combination of the second chamber.
In some preferred modes, linker can be mounted directly on first passage.In some preferred modes
In, linker can be mounted on the first pass with lid.Dress in some preferred modes, on linker and lid
With channel removable connection or combination.In some preferred modes, linker can be installed on assembly channel, this
When linker and lid can be with synchronous movement, as the lid of lid closes, linker can be provide on the first pass.Some excellent
In the mode of choosing, need the sample collected by the second chamber that can enter linker from first passage, then enter second by linker
Chamber.
In some preferred modes, linker is connected to the first chamber by first passage.In some preferred modes, even
Logical device can make first passage and third chamber be in liquid partition state when being connected to the first chamber.
7th aspect of the utility model, the utility model provide a kind of for collecting the second of secondary-confirmation detection sample
Chamber, the second chamber are used to collect and store the sample of secondary-confirmation detection.In some preferred modes, the second chamber is from the first chamber
Obtain sample.In some preferred modes, the second chamber can seal naturally.In some preferred modes, the second chamber is being received
After the sample for collecting sufficient amount, it can be sealed.In some preferred modes, the variable volume of the second chamber.Some preferred
Mode in, the second chamber can be flexible cavity.In some preferred modes, the second chamber can be very before being loaded into sample
Dummy status.In some preferred modes, the second chamber can be sealed by rubber stopper.In some preferred modes, linker
Rubber stopper can be punctured, after linker removes, rubber stopper can seal in interior holding under the conditions of certain pressure, to make second
Chamber has the function of sealing and storing liquid sample.
In some preferred modes, the second chamber directly with the removable combination of the first chamber or connection.In some preferred sides
In formula, the second chamber passes through lid and the removable combination of the first chamber or connection.In some preferred modes, the second chamber passes through dress
Distribution structure and the removable combination of lid or connection.
In some preferred modes, the second chamber and the removable connection of assembling structure.In some preferred modes, second
Chamber can be placed into assembling structure.In some preferred modes, assembling structure is equipped with some engraved structures, passes through these
The part of hollow out can apply certain external force to the second chamber, such as squeeze, and flow out sample therein.In some preferred sides
In formula, the second chamber has an opening, this is open in the case where not being under pressure effect, or in certain pressure range
It is interior to be kept closed, make second it is intracavitary can store a certain amount of sample, the hydraulic of these samples is not enough to open this
A opening, while this opening can be opened by sufficiently large pressure makes the second chamber and external or other cavitys
Realize fluid connection, sufficiently large pressure, such as extruding or the compressing of other modes.
In some preferred modes, the second chamber can be hard cavity.In some preferred modes, the second chamber can be with
It is flexible cavity.In some preferred modes, the second chamber its shape and volume after being loaded into sample can change.One
In some preferred modes, it is smaller that the second chamber can be configured as internal pressure, for example, its internal pressure is less than the first chamber or third chamber, this
Sample, attraction caused by motive force or negative pressure or vacuum caused by pressure difference can be intracavitary by the first chamber or third
It is intracavitary that sample is transferred to second.In some preferred modes, vacuum can be set by the second chamber, in the first chamber and the second chamber
Can be in the case where fluid connection, liquid may will flow to the second chamber from the first chamber due to the effect of pressure difference.Some preferred
Mode in, the second chamber is not necessarily intended to perfect vacuum, as long as making the internal pressure of the second chamber less than the first chamber, also may be implemented above-mentioned
Differential pressure action.In some preferred modes, the first chamber can be pressurized, also can be realized above-mentioned differential pressure action.
The eighth aspect of the utility model, the utility model provide liquid relief element, and liquid relief element can make first intracavitary
Liquid is to the second intracavitary transfer.In some preferred modes, liquid relief element can make the 4th intracavitary liquid to detection zone
Transfer.
In some preferred modes, liquid relief element includes for the first intracavitary sample to be transferred to the second intracavitary
One liquid relief element, and, the 4th intracavitary sample is transferred to the second liquid relief element of detection zone.In some preferred modes
In, the first liquid relief element can move under external force to squeeze the first intracavitary sample, pressure is generated to it, make its to
Required direction or chamber are shifted.In some preferred modes, the second liquid relief element can be under external force
Movement generates pressure to it, shifts it to required direction or chamber to squeeze the 4th intracorporal sample of chamber.
In some preferred modes, the first liquid relief element and the first chamber are in same pipetting channel, push first to move
Above-mentioned extruding may be implemented in liquid element.In some preferred modes, the second liquid relief element and the 4th chamber are in same liquid relief
In channel, push the second liquid relief element that above-mentioned extruding may be implemented.In some preferred modes, the first liquid relief element,
Two liquid relief elements, the first chamber and the 4th chamber are in same pipetting channel, push the first liquid relief element or the second liquid relief element its
One of can be realized simultaneously above-mentioned extruding, in this case, the first liquid relief element and the second liquid relief element may be implemented
The state to link step by step, such as in the case where the first liquid relief element is pushed, the first liquid relief element stress first is mobile, squeezes
First intracavitary sample, the mobile resistance of the second liquid relief element are likely larger than the resistance that the first intracavity liquid is moved, and at this time the
One intracavitary sample is preferentially transferred, when the first intracavitary sample is discharged to the first liquid relief element to the work of the second liquid relief element
When being firmly greater than the resistance of the second liquid relief element movement, the second liquid relief element starts to squeeze the 4th intracavitary sample, so that the 4th
Intracavitary sample is also transferred, alternatively, the second liquid relief element is pushed in other possible situations, the second liquid relief element
Stress is mobile first and squeezes the 4th intracavitary sample, at this point, to be likely larger than the 4th intracavitary for the mobile resistance of the first liquid relief element
The resistance that liquid is moved, the 4th intracavitary sample are preferentially transferred, when the 4th intracavitary sample is discharged to the second liquid relief member
When part is greater than the first liquid relief element mobile resistance to the active force of the first liquid relief element, the first liquid relief element starts extruding first
Intracavitary sample, so that the first intracavitary sample is also transferred.In some cases, it is intended that, when the first liquid relief element and
Under foregoing linkage status, the first intracavitary liquid is preferentially transferred second liquid relief element.
In some preferred modes, fluid connection or partition is may be implemented in pipetting channel and the second chamber.Some preferred
Mode in, fluid connection or partition may be implemented in pipetting channel and detection zone.In some preferred modes, the first liquid relief
Pipetting channel pipetting channel is divided into the first chamber and the 4th chamber by element and the second liquid relief element.In some preferred modes,
Second liquid relief element separates the 4th chamber and the second chamber.
In some preferred modes, when the first intracavitary sample be transferred to second it is intracavitary when, the volume of the first chamber with
Diminution.In some preferred modes, when the volume-diminished of the first chamber, the first liquid relief element and the second liquid relief element are therewith
It draws close.In some preferred modes, when the 4th intracavitary sample is transferred in test zone, the volume of the 4th chamber is therewith
It reduces.Fluid connection in some preferred modes, after the first intracavitary liquid is transferred, between the first chamber and the second chamber
State is separated.Liquid in some preferred modes, when the 4th intracavitary liquid is transferred, between the 4th chamber and third chamber
Body connected state is separated.In some preferred modes, it is by second that the connected state of the 4th chamber and third chamber, which is separated,
Liquid relief element closes second channel to realize in moving process.
In some preferred modes, the initial volume of the 4th chamber is fixed, that is to say, that in the 4th chamber stress by compression
Before, the amount of the 4th intracavitary sample that can be packed into is confirmable.In some preferred modes, the second liquid relief element is being moved
Initial position in liquid channel is fixed.In some preferred modes, the initial volume of the first chamber is fixed, that is to say, that
For one chamber stress by before compressing, the amount of the first intracavitary sample that can be packed into is confirmable.In some preferred modes,
Initial position of the first liquid relief element in pipetting channel is fixed.In some preferred modes, the first liquid relief element and second
Relative initial position of the liquid relief element in pipetting channel is fixed.
In some preferred modes, pipetting channel has a liquid relief opening, can be logical to liquid relief by liquid relief opening
Apply external force in road, realizes above-mentioned extruding.In some preferred modes, liquid relief opening can be by the first liquid relief element or the
Two liquid relief elements are sealed.In some preferred modes, liquid relief element further includes that can push the first liquid relief element and/or
The liquid relief plug of two liquid relief elements.In some preferred modes, liquid relief plug can be open by liquid relief and be protruded into pipetting channel.?
In some preferred modes, the opening of pipetting channel is by some preferred modes, the first liquid relief element and/or the second liquid relief
Element is equipped with and the matched socket of liquid relief plug.
In some preferred modes, sealing element is equipped between liquid relief element and pipetting channel, it is ensured that liquid relief element exists
It, will not there is a situation where samples to reveal between liquid relief element and the inner wall of pipetting channel when being moved in pipetting channel.
9th aspect of the utility model, the utility model provide a kind of method for collecting liquid sample, and this method uses
Foregoing sample collection device, the sample collection device include the first chamber for collecting liquid sample and for collecting really
Recognize the second chamber of detection sample, the first chamber and the second chamber are at the state of fluid connection or partition, when the first chamber and second
When chamber is in fluid connection state, it is intracavitary that the first intracavitary liquid can be transferred to second.
It further include the third chamber for collecting sample, third chamber and the first chamber can be in some preferred modes
One chamber is in the state of fluid connection or partition, and the collection of initial sample can be carried out by third chamber, and first is intracavitary collected
It is intracavitary for secondary detection purposes may to be transferred to second for the sample arrived.
In some preferred modes, when the first chamber and third chamber are in fluid connection state, the intracavitary collection of third
Liquid can enter the first chamber simultaneously, that is to say, that third chamber carry out sample initial collection when, first it is intracavitary while
The sample of initial collection can be packed into.
In some preferred modes, when the first intracavitary liquid be transferred into second it is intracavitary when, at the first chamber and third chamber
Separate state in liquid, since the second intracavitary sample is detected for secondary-confirmation, not in order to ensure the second intracavitary sample
It is contaminated, just the first chamber is isolated with other chambers before transfer.
It further include the 4th chamber for collecting sample to be detected in some preferred modes, the 4th chamber can be with third
Chamber is in the state of fluid connection or partition.
In some preferred modes, when the 4th chamber is in fluid connection state with third chamber, the intracavitary collection of third
Liquid can enter the 4th chamber simultaneously, and the 4th chamber can also be at the shape being connected to when initial collection sample with third chamber
State, such 4th chamber can also substantially simultaneously complete required sample, the 4th intracavitary collected sample with third chamber
Originally it is mainly used for primary detection, primary detection can also can be transferred to other by the 4th chamber directly in the 4th intracavitary progress
Region carries out, such as detection zone.
Further include detection zone in some preferred modes, the 4th chamber can be in detection zone fluid connection or
The state of partition, when the 4th chamber is when initial collection, the 4th chamber can be isolated with detection zone to come, that is to say, that
Collection and detection can be independent from each other link.
In some preferred modes, when the 4th chamber is in fluid connection state with detection zone, the 4th chamber and third
Chamber is in liquid partition state, on the one hand may insure the pollution effect that detection zone not may cause by other chambers, another
Quantitative detection may be implemented in aspect, as long as the volume of the 4th chamber of setting, so that it may realize and determine the sample for entering detection zone
Amount.
In some preferred modes, the second chamber and third chamber can be combined or be separated.In some preferred modes,
Second chamber and the first chamber can be combined or be separated.Due to the second chamber be need to get from the first chamber or third chamber it is collected
Sample, therefore the second chamber must with the first chamber or third chamber or one of them establish the relationship of fluid connection, when obtaining
After having got required sample, the second chamber has to be independent sealed and save cavity therein again, or even will be by independence
It is transported, is sent to secondary detection mechanism, therefore the second chamber has to and the first chamber or third chamber or one of them point
From, in some preferred modes, the second chamber can with the first chamber or third chamber or one of them removable combination or
Person's connection.
It further include the communication apparatus between the first chamber and the second chamber, communication apparatus first in some preferred modes
Intracavitary sample enters second and intracavitary provides advantageously channel and a path.
In some preferred modes, when initial collection sample, communication apparatus is not installed in place, need into
When row secondary-confirmation is collected, then communication apparatus is installed.
In some preferred modes, communication apparatus can allow the first chamber and the second chamber to be in the state of fluid connection can also
The connected state of the first chamber and the second chamber to be separated.
In some preferred modes, communication apparatus can separate the connected state of the first chamber and third chamber.When initial
It is pollution-free in order to ensure secondary-confirmation sample after the completion of the collection of sample, first the first chamber and third chamber can be separated.
In the present invention, since can not to enter second naturally intracavitary for initial collected sample, it is necessary to pass through
Under certain external force, in this case, just have to take initial collected sample certain active force.
Therefore, in some preferred modes, the method for the utility model also provides a kind of liquid relief element, in initial collection
After the completion, the first intracavitary sample for having had sufficient amount squeezes the first intracavitary sample then pushing liquid relief element at this time
Pressure makes it direct or through communication apparatus and enters second intracavitary, and simultaneously, the volume of first chamber itself is compressed.?
In some preferred modes, liquid relief element can also be shifted the 4th intracavitary sample.In some preferred modes, the
The transfer of four intracavitary samples can be after the first intracavitary sample transfer.In some preferred modes, the first chamber and the 4th chamber
Different liquid relief elements can be respectively adopted to be squeezed.In some preferred modes, the liquid relief member of the first chamber and the 4th chamber
It may be implemented to link between part.
In some preferred modes, the method for the utility model also provides pipetting channel, and above-mentioned liquid relief element can
It is moved in pipetting channel, to squeeze the first chamber or the 4th intracavitary liquid.In some preferred modes,
First chamber or the 4th chamber can be a certain section in pipetting channel, be separated to form chamber by different liquid relief elements
Body.In some preferred modes, the first chamber can realize fluid connection with the second chamber.In some preferred modes, the 4th
Chamber can realize fluid connection with detection zone.That is, inherently can be with the second chamber or detection as pipetting channel
Region or the two connection.
In some preferred modes, the method for the utility model also provides a kind of liquid relief plug, and liquid relief plug is mainly used for
Mobile power is provided to liquid relief element, keeps it mobile to the first chamber and/or the 4th intracavitary sample in pipetting channel
The power squeezed is generated, these samples are shifted.
In some preferred modes, the method for the utility model also provides the sealing between liquid relief element and pipetting channel
Structure, it is ensured that when liquid relief element stress is mobile, gap will not be generated between the inner wall of pipetting channel, sample will not occur
Leakage.
Tenth aspect of the utility model, the utility model, which provides, whether there is analyte in a kind of detection liquid sample
The method of matter, the detection method include the sample collection device of any one above-mentioned mode, are received by sample collection device
Collect sample to be detected, after the 4th intracavitary collection has sample, sample therein is detected.In some preferred modes
In, after the intracavitary collection of third has sample, sample therein is detected.It is intracavitary by the 4th in some preferred modes
Sample be transferred to detection zone it detected.In some preferred modes, the intracavitary sample of third is transferred to inspection
Region is surveyed to detect it.After obtaining testing result, allow the second chamber according to above-mentioned arbitrary mode and sample collection device
It is separated.
The beneficial effects of the utility model are: using the structure of the utility model, have the characteristics that simple and reasonable, makes
With lower cost for material, function admirable;Convenient for secondary detection.Particularly, when needing to carry out subsequent confirmation detection, no
It needs entire detection device to be sent to mechanism for testing and is detected, and be only to remove the second chamber from device, be sent to examine
Geodesic structure, it is not only safe in this way, but also space is saved, save the cost is more environmentally-friendly.
Detailed description of the invention
Fig. 1 is the overall structure figure of sample testing apparatus in a specific embodiment.
Fig. 2 is the partial exploded view of sample testing apparatus in a specific embodiment, and lid is in the open state in figure,
Liquid relief plug is not stuffed into.
Fig. 3 is the schematic diagram of lid in a specific embodiment, and the second chamber and linker have been fitted on lid at this time.
Fig. 4 is schematic diagram of the lid shown in Fig. 3 from another angle.
Fig. 5 is the structure chart on lid top shown in Fig. 3, shows the handle or knob structure of assembly.
Fig. 6 is the schematic diagram of lid in a specific embodiment, and the second chamber is not yet assembled on lid at this time.
Fig. 7 is the assembling relationship figure of the second chamber and assembling structure and linker in a specific embodiment.
Fig. 8 is the assembling relationship figure of the second chamber and linker in a specific embodiment.
Fig. 9 is the schematic diagram of linker in a specific embodiment.
Figure 10 is the bottom view of linker in a specific embodiment.
Figure 11 is the top view of linker in a specific embodiment.
Figure 12 is the schematic diagram of the second chamber in a specific embodiment.
Figure 13 is the schematic diagram from another angle of the second chamber shown in Figure 12, can be seen that second from the angle of Figure 13
The bottom of chamber has an opening, which can make the second chamber and external or other cavitys realize fluid connection.
Figure 14 is the schematic diagram that the opening in the second bottom of chamber portion shown in Figure 13 is sealed.
Figure 15 is the schematic diagram of another angle of the second chamber shown in Figure 12, as can be seen from Figure 15, when the second chamber
It is inside not already built into sample, the second chamber can be punctured into flat state.
Figure 16 is the schematic diagram of the assembling structure of the second chamber in a specific embodiment.
Figure 17 is schematic diagram of second chamber in conjunction with assembling structure in a specific embodiment.
Figure 18 is that the second chamber is loaded into the schematic diagram after sample in Figure 17.
Figure 19 is the schematic diagram that the second chamber is completed to separate after sample collection with linker in a specific embodiment.
Figure 20 is the schematic diagram of third chamber in a specific embodiment, and third chamber can be a box body, in this tool
In the embodiment of body, detection zone be can be set in the side of third chamber.
Figure 21 is schematic diagram of the third chamber in Figure 20 from another angle, from this angle can show first passage and
Position where second channel.
Figure 22 is schematic diagram of the third chamber in Figure 20 from another angle, can show pipetting channel from this angle
Part-structure.
Figure 23 is the schematic diagram of third chamber in another embodiment, in this specific embodiment, third
A sealed connection lid is assembled on chamber.
Figure 24 is the schematic diagram of the sealed connection lid on third chamber shown in Figure 23.
Figure 25 is the schematic diagram of another angle of the sealed connection lid in Figure 24.
Figure 26 is the cross-sectional view of third chamber in a specific embodiment, in the state of shown in this figure, the first liquid relief member
Part and the second liquid relief element are not yet mounted in pipetting channel.
Figure 27 is the cross-sectional view of pipetting channel in a specific embodiment, and in the state of shown in this figure, first is moved
Position when the location of liquid element and the second liquid relief element are not used by for device, at this time the first chamber and the 4th chamber be by
Compression, first passage and the first chamber are in fluid connection state, and second channel and the 4th chamber are in fluid connection state.
Figure 28 is the cross-sectional view of pipetting channel in a specific embodiment, in the state of shown in this figure, the second liquid relief
Element is mobile to the direction for squeezing the 4th chamber, starts simultaneously at and is sealed to second channel.
Figure 29 is the cross-sectional view of third chamber in a specific embodiment, in the state of shown in this figure, the first liquid relief member
Part and the second liquid relief element are by liquid relief plug top to inside extreme position, at this point, the 4th chamber and the first chamber are compressed, the 4th chamber
Interior sample is pushed into detection zone, and the first intracavitary sample is pushed into second intracavitary, and the first chamber and first passage are in liquid
Body separates state, and the 4th chamber and second channel are in liquid partition state.
Figure 30 is the schematic diagram of liquid relief plug in a specific embodiment.
Figure 31 is the schematic diagram of the first liquid relief element in a specific embodiment.
Figure 32 be in a specific embodiment the first liquid relief element from the schematic diagram of another angle.
Figure 33 is the schematic diagram of the second liquid relief element in a specific embodiment.
Figure 34 be in a specific embodiment the second liquid relief element from the schematic diagram of another angle.
Figure 35 is the schematic diagram of sealing structure on the first liquid relief element and the second liquid relief element in a specific embodiment.
Figure 36 is the assembly relation schematic diagram of linker and first passage.
Figure 37 is the schematic diagram of the first chamber, third chamber and linker in a specific embodiment.
Figure label: the first chamber 41, the second chamber 42, third chamber 43, the 4th chamber 44, detection zone 45 detect entrance 46, the
One channel 47, second channel 48, collection port 49, collecting tank 50, pipetting channel 51, the first liquid relief element 52, the second liquid relief element
53, detect entrance partitions 54, open end 55, opening 56, sealing element 57, linker 58, puncturing elements 59, connection chamber 60, platform
Terrace 61, the assembling structure 62 of the second chamber, lid 63, tapered surface 64, testing element entrance 65 are tightly connected lid 66, the first lid
67, the second lid 68, the connecting portion 69 with lid cooperation, assembly channel 70, assembling structure outer wall 71, assembling structure inner cavity 72,
Engraved structure 73, fixed ring 74, assembling connecting piece 75, sealing element 76, liquid relief opening 77, liquid relief plug 78, first movement chamber 79,
Support leg 80, seal groove 81, third channel 82, pressure port 83.
Specific embodiment
The utility model is described in further detail below in conjunction with attached drawing, it is noted that embodiment is pair
The specific descriptions of the utility model are not construed as the restriction to the utility model.
First to the utility model relates to structure or used technical term be described further, if without spy
It does not indicate, is understood and explained according to general technology term generally in the art.
Detection
Detection indicates chemical examination or tests a kind of substance or material to whether there is, for example, but it is not limited to this, chemical substance,
Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation
Thank object, nucleic acid, protein or polymer.In addition, detection indicates the quantity of test substances or material.Furtherly, table is gone back in chemical examination
Show immune detection, chemical detection, enzyme detection etc..
Confirmation detection
Confirmation detection is properly termed as secondary detection, secondary-confirmation detection again, may be sun when first time testing result is shown
Property or weakly positive in order to ensure the accuracy of testing result or obtain more accurate detection when being perhaps unable to judge accurately
As a result, it is desirable to will be sent to a batch of sample (optimal is same batch acquisition) non-at-scene or farther away with confirmation
The place of detection qu alification carries out second and detects, to verify testing result.The purpose of confirmation detection is to scene or primary detection
As a result a kind of confirmation operation, the instrument examined may be more accurate, and the method for inspection may be more tight, but basic
Principle be identical or approximate, only reinspection on the basis of initial survey with initial survey.
Sample
The sample that the detection device of the utility model can detecte includes biofluid (such as casing fluids or clinical sample
Product).Fluid sample or fluid sample can from the sample of solid-state or semisolid, including excreta, biological tissue and
Food samples.The sample of solid-state or semisolid can be converted to fluid sample using any method appropriate, such as mix, smash
It is broken, macerate, be incubated for, dissolution or in a suitable solution (such as water, phosphate solution or other buffer solutions) using enzymatic hydrolysis make
With digestion of solid sample." biological sample " includes deriving from animal, plant and food samples, for example including from human or animal
Urine, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, organ, tumor,
The culture of tissue and organ, cell culture and medium.It is preferred that biological sample is urine.Food samples include the object of food processing
Matter, final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, plant tissue, and plant is thin
Born of the same parents' culture and medium." environmental sample " from environment (for example, from lake or the fluid sample of other water bodys, sewage
Sample, soil property sample, underground water, seawater and waste liquid sample).Environmental sample may also include sewage or other waste water.
Using the utility model and suitable detecting element, any analyte can detecte.It is practical new preferably by this
Drugs small molecule in type detection saliva, urine.Certainly, any of the above shape can be collected using the collection device of the utility model
No matter the sample of formula is initially solid or liquid, as long as these liquid or liquid sample are flowed into some chamber
Afterwards, these liquid samples can flow into other chambers simultaneously or later, due to other chambers can with flow into first
Chamber combines or separation, and when initial collection sample, the chamber and other chambers flowed into first is combined, and user passes through primary
Collection movement can complete the collection of the liquid sample to required multiple chambers, when needing to carry out subsequent confirmation detection,
Allow wherein some chamber and overall separation, thus, one of chamber or the indoor liquid sample of multiple chambers can carry out for the first time
Detection, and the liquid sample in that chamber being separated can carry out secondary detection.Optionally, the function of these chambers
Status also can be interchanged, that is to say, that the liquid sample in which chamber can carry out primary detection, the liquid in which chamber
Sample, which can carry out secondary detection, can be interchanged.
Testing element
Testing element can select the test strip of lateral flow, it can detect a variety of analytes.Certainly, other are closed
Suitable testing element can also be used in the utility model, all to can detecte sample or sample is whether containing interested
The element of analyte can be referred to as testing element, this to detect which kind of Yuan technical principle be either based on, immunology,
Chemistry, electricity, optics, physics etc. are ok.
Various testing elements can be grouped together and apply in the utility model.A kind of form is Test paper.With
The Test paper of analyte (such as drugs or showing the metabolin of physical condition) in analysis sample can be various forms,
Such as immunoassays or the form of chemical analysis.Test paper can be using non-competing method or the analytical model of competition law.Detection examination
Paper bag is containing a water-absorbent material with sample application zone, reagent area and test section.Sample-adding passes through capillary originally to sample application zone
Effect flows to reagent area.In reagent area, if there is analyte, sample is in conjunction with reagent.Then sample continues to flow to inspection
Survey area.Other reagents, such as molecule with analyte specific binding are fixed on detection zone.In these reagents and sample
Analyte (if present) reacts and analyte is incorporated in the area, or in conjunction with some reagent of reagent area.With
Exist and reagent area or isolated mark zone in the marker of display detection signal.
Typical non-competing method analytical model is if containing analyte in sample, and signal will generate, if do not wrapped
Containing analyte, signal is not just generated.In competition law, if analyte is not present in sample, signal is generated, if deposited
In analyte, then signal is not generated.
Testing element is Test paper, the material that can be selected water suction or not absorb water.Test paper may include multiple material
It is transmitted for liquid sample.The material of one of Test paper can cover on another material, as filter paper is covered on nitric acid
On cellulose membrane.One area of Test paper can select one or more materials, and one kind that another area selects other different
Or multiple material.Test paper can be attached on certain support or hard surface and be affectedly bashful the strong of Test paper for improving
Degree.
Analyte is detected by signal generating system, such as utilizes one with this analyte generation specific reaction
Kind or a variety of enzymes, are fixed on the method on Test paper for specific combinating substance using such as aforementioned, one or more signals are sent out
The composition of raw system is fixed on the analyte detection zone of Test paper.Generate signal substance can in sample application zone, reagent area,
Or on detection zone, or entire Test paper, which can be full of on one or more materials of Test paper.Signal will be contained
The solution of object is added to the surface of test paper or one or more materials of test paper is immersed in the solution of the object containing signal.Make to be added and contain
The test paper of signal object solution is dry.
Each area of Test paper can arrange in the following manner: sample application zone, reagent area, detection zone, control zone determine sample
This whether adulterated area, liquid sample uptake zone.Control zone is located at after detection zone.All areas can be arranged at only with a kind of
On one test paper of material.It can also be not same district and use different materials.Each area can directly be contacted with liquid sample, or not
Direction arrangement of the same area according to liquid sample flowing, the end in each area is connected and is overlapped with the front end in another area.Used
Material can be the preferable material of water imbibition such as filter paper, glass or nitrocellulose filter etc..Test paper can also use it
His form.
General common reagent strip is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitre
Specific binding molecule is fixed on acid cellulose film to show the result of detection;It can also be cellulose acetate film or nylon membrane etc.
Deng.Such as the description of the following patent reagent strip or device containing reagent strip: US 4857453;US 5073484;US
5119831;US 5185127;US 5275785;US 5416000; US 5504013;US 5602040;US 5622871;US
5654162;US 5656503;US 5686315; US 5766961;US 5770460;US 5916815;US 5976895;US
6248598;US 6140136; US 6187269;US 6187598;US 6228660;US 6235241;US 6306642;US
6352862; US 6372515;US 6379620;With US 6403383.Test-strips disclosed in patent documents above and band
There is the similar device of test-strips that can be applied in the testing element or detection device of the utility model to be analyzed
The detection of substance, for example, in sample analyte detection.
Apply to the lateral effluent reagent strip (Lateral that the detection reagent item of the utility model can be known as
Flow test strip), the specific structure and testing principle of these detection reagent items are the general skill in this field in the prior art
Technology well known to art personnel.Common detection reagent item, including sample collection region, marked region, detection zone and suction zones
Domain, sample collection region include sample receiving pad, and marked region includes label pad, and suction zone may include water absorption pad, wherein
It include that can detect whether the necessary chemical substance containing analyte, such as immunoreagent or enzymology are tried in detection zone
Agent.General common detection reagent item is nitrocellulose assay strip, i.e. detection zone includes nitrocellulose filter, in nitric acid
Specific binding molecule is fixed on cellulose membrane to show the result of detection;It can also be cellulose acetate film or nylon membrane etc.,
It certainly, can also include testing result control area in the downstream of detection zone, in general, with cross in control area and detection zone
The form of line occurs, and is detection line or control line.Such detection reagent item is that traditional reagent strip can also be it certainly
The other types of reagent strip that he is detected using capillarity.In addition, having dry chemistry reagent on general detection reagent item
Ingredient, such as fixed antibody or other reagents, after encountering liquid, liquid is flowed with capillarity along reagent strip,
With flowing, dry agent formulations is allowed to be dissolved in liquid, so that the dry reagent to next regional processing in the area reacts,
To carry out necessary detection.Liquid flowing mainly carries out through capillary action.These testing elements are shown in retouching for following file
It states and records: " regeneration treatment of nitrocellulose filter and its research of adhesion protein ability " of Li Fugang;Ma Hongyan, Li Qiang etc.
The analysis of membrane material characteristic " in colloidal gold diagnosis kit chromatograph ";Wang Yong, Wang Luhai etc. " a kind of new colloidal gold is immune
Chromatograph test strip ".Can be applied in the detection device of the utility model herein, or be arranged in test chamber with
Liquid sample contact either whether there is or existing for detecting analyte in the liquid sample entered in test chamber
Quantity.
In addition to above-mentioned testing element is in the form of reagent strip, itself it is used to and some biggish chamber, such as sheet
The liquid contact of third chamber 43 in application comes in test liquid samples whether contain outside analyte, in some preferred sides
In formula, testing element can also be arranged in the test card of a concentration, have many grooves, testing element position in test card
In groove, entire test card is arranged in detection zone 45, due to having between third chamber 43 and detection zone 45 by two
The detection entrance 46 of person's connection, the liquid sample entered in third chamber 43 can enter detection zone by detecting entrance 46
In domain 45, so that the testing element on tested card is detected.Certainly, in addition to carrier disclosed above, carrier in addition can also
To be applied in the utility model as the carrier of bearing test item.For example, in some modes, third chamber 43 or other
Chamber can first collect liquid sample, then with individually with test-strips or the card with test-strips or carrier are inserted into
It is detected in three chambers 43.Those of ordinary skill in the art are appreciated that according to documented by the utility model, these are tested
Item can be not provided on carrier, but be individually present, and the detection zone 45 of the utility model is also in some cases
It can lack, test-strips are also that can lack in some cases.
The flowing of liquid
The flowing of liquid, and the flowing of sample or the flowing of liquid sample, in some cases, sample can be referred to as
Transfer be also to be realized by flowing, the circulation of liquid typically refers to flow to from a place another place, one
As in the case of, the flowing of the liquid of nature is most of to flow to lower from eminence by the effects of gravity, and flowing here is also
By external force, i.e., flowing under external gravitational conditions can become the flowing of natural gravity.In addition to gravity, liquid
Flowing can also overcome gravity, carry out the movement that eminence is flow to from lower.For example, the extraction of liquid or the compressing of liquid,
Or liquid is under pressure, and flow to eminence from lower, also or due to pressure relationship and overcome the gravity of liquid itself
And the flowing carried out.
For example, third chamber is located on the first chamber and the 4th chamber, and the 4th chamber is located under third chamber in Figure 27-29, when there is liquid
When into third chamber, liquid relies on the gravity of itself, naturally gravity flowing can be relied on to first from third chamber
In chamber and the 4th chamber, downstream position can also be flow to naturally from upstream, when device integrally rocks, liquid be also possible to because
For gravity direction change and the variation that flows to.
Analyte
It can include some small-molecule substances with the example of the analyte involved in the utility model, these small molecule packets
Include drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is usually played using drug in non-medical destination
With).It abuses these drugs and will lead to body & mind and be damaged, generate dependence, addicted and/or dead.Drug is indiscriminate
Example includes cocaine;Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation
Amphetamine tablet, Beans);Crystal methamphetamine MET (crank, meth, crystal, speed);Barbiturate
BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey);Sedative (i.e. sleep adjuvant
Product);Lysergic acid diethylamide (LSD);Inhibitor (downers, goofballs, barbs, blue devils, yellow
Jackets, methaqualone);The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin);Two methylenedioxy groups
Methylaniline MDMA;Phencyclidine (PCP);Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..);Opiate
(i.e. morphine MOP or opium, cocaine COC, heroin, hydroxyl dihydrocodeinone);Anxiolytic and hypnotic sedative agent resist
Anxiety medicine is that one kind is mainly used for anxiety reduction, anxiety, fear, sets the mind at rest, has the drug of hypnosis sedation, including benzene concurrently
Diazepine BZO (benzodiazepines), atypia BZ class, fusion phenodiazine NB23C class, benzene nitrogen Zhuo class, BZ receptor are matched
Body class, open loop BZ class, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole
Derivative, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propylene glycol are derivative
Object-carbamates, aliphatic compound, anthracene derivative etc..It can be used for examining using the detection device of the utility model
The detection for belonging to medical usage but being easy overdose is surveyed, such as tricyclic antidepressant (imipramine or the like) and acetyl ammonia
Base phenol etc..These drugs can be metabolized to small-molecule substance after being absorbed by the body, these small-molecule substances be present in blood, urine,
In the body fluid such as saliva, sweat or part body fluid there are above-mentioned small-molecule substances.
For example, with the utility model detect analyte include but is not limited to, creatinine, bilirubin, nitrite,
Albumen (non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood
Ball, sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as Escherichia coli
0157:H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bar
Bacterium) and urine sample in substance relevant to physiological characteristic, such as pH and specific gravity.Other any Clinical Urinary chemical analyses are all using lateral
Flow test format cooperation utility model device is detected.
Connection and/or partition
In the present invention, connection refers to a kind of state of fluid communication, that is, in this structure, fluid can
From a region to another region, perhaps can be from a part of structure to another part or can be from the of structure
For one cavity to another cavity, " to " here is realized by the mobility of fluid itself, and connection specifically refers to flow
Body connection, i.e. gas connection or fluid connection.Gas connection or fluid connection refer to that liquid or gas can be from one
Place flow to another place, may play guiding function by the structure of some physics during flowing.So-called process
The structure of physics generally refers to the space of inside on surface or these structures of the liquid by the structure of these physics and passive
Or another place is actively flowed to, passive is usually the flowing received under flowing caused by external force, such as capillarity.
Here flowing is also possible to liquid or gas because of self-acting (gravity or pressure), is also possible to passively flow.
Here connection is not offered as that liquid or gas is centainly needed to exist, and only shows in some cases between two objects
Connection relationship or state can be from a material flows to another object if there is liquid exists.This refers to two
The state of object connection, on the contrary, if not having fluid connection or gas connection state between two objects, if there is liquid exists
In one object perhaps on liquid cannot flow in another object or on, such state be non-interconnected, on-liquid
Or the state of gas connection.In the present invention, sometimes also directly by this gas connection or the shape of fluid connection
State, referred to as be in fluid communication or referred to as be connected to, it is this connection do not need physical presence fluid in structure (such as liquid or
Person's gas), only structure is at the expression of such a state.Correspondingly, the partition in the utility model refer to
It is connected to (fluid communication) opposite state, i.e., is not connected to, that is to say, that under partition state, fluid can not be in the work of mobility
With it is lower realize it is above-mentioned from a region to another region, perhaps can from a part of structure to another part or
Can be from first cavity of structure to another cavity, equally, partition does not need physical presence liquid in structure yet, can be only
It is a kind of state of structure.
Detection device or collection device
Detection device refer to for detect in sample whether the device containing analyte.Collection device refers to carry out liquid
The device of collection and the storage of body sample.Detection device may include collection device, and collection device also may include detection device,
Or collection device is separated with detection device, when detection, is combined to collection device and detection device, thus complete
At detection.It is also possible to collection device and device that detection device is structure as a whole, after collecting liquid sample, so that it may
It is detected at once, obtains test result, while carried out detection sample and collecting the separation of sample, so as to carry out secondary inspection
It surveys (if necessary).Here the meaning of detection device or test chamber can be interchanged, and collection device and collection chamber can also
To exchange, only play the role of exchange that is different and carrying out function.For example, when the utility model mentions collection device,
It can not include test chamber, but collection device may include having testing element or the carrier containing testing element, contain survey
The collection device of examination element can also be referred to as detection device.Certainly, collection device may include for testing element is arranged
Space, but be not necessarily required to containing testing element, testing element can be when subsequent any suitable and collection device
It is combined and becomes detection device.For example, collection device may include the space for accommodating testing element, such as contain inspection
Region 45 is surveyed, either has suitable position testing element is arranged or containing survey in the chamber of the collection liquid of collection device
Try the carrier of element.
For collecting the first chamber of liquid sample
In some specific embodiments of the utility model, in concrete mode as can be seen in figures from 27 to 29, the utility model
It provides a kind of for collecting the collection device of liquid sample, or the detection device for detecting liquid sample, certainly, the detection
It also includes this collection device of collection device that device, which also has the function of collection perhaps, or detection device includes the first chamber 41,
First chamber 41, which can be used as the chamber directly collected, to be come using can also realize sample by other chambers such as third chamber 43
This collection.
When the first chamber 41 is as the cavity directly collected, the opening outside a direct connection itself can have,
It can be injected or loaded into sample, such as structure shown in Figure 26 into the first chamber 41 by the opening, the first chamber 41 can be at this time
Sample is directly collected from external.When the first chamber 41 realizes the collection of sample by other chambers, as can be seen in figures from 27 to 29,
It is directly connected to by a first passage 47 with third chamber 43, also, the first chamber 41 is located at the lower section of third chamber 43, third chamber
43 have a upward collection port 49, and by the collection port 49, liquid sample can be entered in third chamber 43 and in gravity
It acts on lower nature to fall or toward flowing down, fall naturally and the can be fallen directly into the part liquid sample of first passage
In one chamber 41, some inevitable liquid sample can not fall directly into first passage 47 in natural dropping process, then
This partially liq sample can gather in the bottom of third chamber 43, when liquid level is more than to be higher by third chamber from first passage 47
When the height of 43 bottoms, this partially liq will be flowed into the first chamber 41 by first passage 47.
In some preferred modes, for example, as can be seen from the figure, it can be opened up on the side wall of first passage 47
One collecting tank 50, this collecting tank 50 can be flushed with the bottom of third chamber 43 or the bottom of slightly above third chamber, certainly
In right dropping process and does not enter the part liquid sample of first passage 47 and can finally be pooled to the bottom of third chamber 43, due to
Relatively, the liquid sample in 43 bottom of third chamber may pass through greatly collection to the bottom level of collecting tank and third chamber 43 very much
Slot 50 enters in first passage 47 to be flowed into the first chamber 41 along first passage 47.It should be noted that due to me
Do not need sample all in third chamber 43 and be all flowed into the first chamber 41, it is only necessary to a part therein, therefore, only
The amount for the liquid to be collected into is enough, will necessarily some sample can enter in first passage 47, also, due to actually making
In, entire cavity may be in the state of a nonstatic, such as be held, then the collected sample of institute also due to
It rocks and more possibly enters in collecting tank 50 greatly.
In some preferred modes, the liquid sample in the first chamber 41 is used directly for detecting.Some preferred
In mode, the liquid sample in third chamber 43 is used directly for detecting.Liquid in some preferred modes, in the first chamber 41
Body sample can be transferred in other cavitys, such as the second chamber 42.
In some preferred modes, the volume of the first chamber 41 is variable, for example, shown in Figure 27-29 during,
One chamber 41 is actually one section of space in pipetting channel 51, this section of space is by the first liquid relief element 52 and the second liquid relief member
Part 53 is isolated and is formed, when the first liquid relief element 52 or the second liquid relief element 53 or two liquid relief elements are logical in liquid relief
When moving in road 51, the volume of the first chamber 41 will change.In some preferred modes, the volume of the first chamber 41 can be with
It is compressed, the liquid sample wherein stored at this time can be extruded, until in other chambers or for other purposes.Some preferred
Mode in, the volume of the first chamber 41 can also be extended, and in this case, can generate inside attraction in the first chamber 41
Power makes it faster be collected into more liquid samples, alternatively, in some preferred modes, the volume of the first chamber 41 can be with
The increase of collected sample and expand.
Self-sealing
The self-sealing refers to, the object that is accommodated in addition to cavity itself or cavity (including liquid, gas with
And other substances) may be acted on without other any active forces other than pressure caused by the inner wall or outer wall to cavity
When on cavity, cavity be may be between sealing state, inside cavity and the external world or other cavitys in fluid isolation
State, fluid communication (including liquid, gas etc.) can not be allowed.In some cases, the self-sealing refers to, in addition to
The object (including liquid, gas and other substances) accommodated in above-mentioned cavity itself or cavity may be in cavity
Even if wall perhaps applies certain external force to the inner wall or outer wall of cavity other than pressure caused by outer wall, as long as outside this
Power is not sufficiently large or does not reach certain value, and cavity is still within the state of above-mentioned sealing.In some cases, on cavity
There may be being open the hole being perhaps punctured but the material as used by cavity or the relationship with certain wall thickness, this
A hole for being perhaps punctured of being open also can satisfy above-mentioned in internal force or under not sufficiently large external force, will not open
Condition, also, when being applied with external force or external force is sufficiently large, cavity do not need other component intervention can with it is outer
Boundary or other cavitys realize fluid connection (can be through the opening or the hole being punctured), and remove in this external force
After going, and when can be restored to original fluid isolation state, this cavity is referred to as by we can be with the cavity of self-sealing.
For collecting the third chamber of liquid sample
In some specific embodiments of the utility model, such as Figure 20-23, the utility model provides a kind of for collecting
The collection device of liquid sample, or the detection device for detecting liquid sample, certainly, which also has collection
Function also includes perhaps this collection device of collection device or detection device includes third chamber 43, and third chamber 43 can be used as
The chamber directly collected come using, can also be used as detection cavity come using or the third chamber 43 be also used as one
The cavity temporarily stored makes to enter in other cavitys into liquid sample therein by third chamber 43, other cavitys
It can be collection chamber, be also possible to test chamber.
For example, third chamber 43 collects the transition of liquid sample as the first chamber 41 in the concrete mode shown in Figure 27-29
Cavity, by foregoing some modes, the first chamber 41 can be collected simultaneously the liquid sample into third chamber 43.When
Right third chamber 43 can also collect sample by other chambers.
When third chamber 43 is as a transitional cavity, as shown in figure 21, bottom be may have and 41 liquid of the first chamber
The first passage 47 of body connection, and the second channel 48 with 44 fluid connection of the 4th chamber, in this case, as long as first is logical
Road 47 and second channel 48 are not closed, then the first chamber 41 and the 4th chamber 44 can be able to be substantially same with third chamber 43
Step completes the collection of sample.
In some preferred modes, third chamber 43 can also realize liquid by a detection entrance 46 and detection zone 45
Body connection, detection entrance 46 can be adjusted or be set as to be connected to or separate, thus can according to need third chamber
Liquid in 43 is introduced into detection zone 45, and testing element can be set in detection zone 45, can also be not provided with test member
Part.When testing element is arranged in detection zone, for the ease of observation, detection zone can be made of transparent material.
In some preferred modes, a collecting tank 50 can be opened up on the side wall of first passage 47, this collection
Slot 50 can be flushed with the bottom of third chamber 43 or the bottom of slightly above third chamber, in natural dropping process and does not enter
The part liquid sample in one channel 47 can finally be pooled to the bottom of third chamber 43, due to the bottom of collecting tank and third chamber 43
Relatively, the liquid sample in 43 bottom of third chamber may be entered in first passage 47 greatly height by collecting tank 50 very much
To be flowed into the first chamber 41 along first passage 47.It should be noted that since we do not need institute in third chamber 43
Some samples are all flowed into the first chamber 41, it is only necessary to a part therein, therefore, as long as the amount for the liquid being collected into is enough,
Will necessarily some sample can enter in first passage 47, also, due to actual use in, entire cavity may be in
The state of one nonstatic, such as held, then the collected sample of institute is also due to rocking and more possibly entering greatly
In collecting tank 50.
In some preferred modes, the first chamber 41 and third chamber 43 can be isolated when initial collection in liquid
State, that is, the liquid sample as collected by third chamber 43 will not automatically into or can not sample be self-possessed effect
It is entered directly under power in the first chamber 41, such as the connected relation between the first chamber 41 and third chamber 43 is separated by some element,
After applying certain active force to the liquid sample in third chamber 43, the partition of this element can be broken through, to make sample
This enters in the first chamber 41 out of third chamber 43.That is, in this case, the first chamber 41 is not necessarily intended to as at the beginning of one
Beginning collects the cavity of sample, can be used as a channel, this channel enters the second chamber 42 from third chamber 43 for sample and mentions
A paths are supplied, due to the presence in this path, sample can be entered directly into inside the second chamber 42 without polluting second
The outer wall of chamber 42.
In some preferred modes, third chamber 43 can be sealed with coverd part.In some preferred modes, lid can be with
Directly and the connection of third chamber 43 is to seal third chamber.In some preferred modes, lid can be sealed directly including detection
Third chamber including region.In some preferred modes, lid can be only used for the collection port of sealing third chamber.Some excellent
In the mode of choosing, lid can be connect by sealed connecting component with lid.Such as shown in Figure 24-25, for collection port 49 and survey
The sealing for trying element inlet 65 can be using lid 66 be tightly connected, and being tightly connected lid 66 include for covering sample collection entrance the
One lid 67 and the second lid 68 for covering testing element entrance 65 pass through the first lid 67 and the second lid 68, are tightly connected lid 66
Collection port 49 and testing element entrance 65 can be covered simultaneously, lid can be reconnected by being tightly connected lid 66, alternatively, sealing connects
Fitting inherently sealing state, as shown, the first lid 67 and the second lid 68 are engaged by clamping in third chamber and detection zone
Opening portion.Other than mode shown in figure, thermoplastic envelope can also be carried out with film, as long as guaranteeing when detection,
The diaphragm seal is airtight or no leakage can, after completing detection, after allowing the second chamber to separate with apparatus main body, device
Main body (including detection zone) can make discard processing, without entire detection device is stored and transported.
In some preferred modes, it is first packed into sample into third chamber 43, is not loaded into sample in the first chamber 41.
In some preferred modes, the sample in third chamber 43 can enter in the first chamber 41 under the action of certain external force.For example,
As shown in figure 37, in some preferred modes, the third channel 82 for passing through third chamber 43 is can be set in the first chamber 41,
When initial collection, sample will not be loaded into this third channel 82.In some preferred modes, the second chamber 42 and second
The assembling structure of chamber can be assembled on third channel, similarly can be connected to the first chamber and the second chamber 42 with linker 58.?
In some preferred modes, the sample in third chamber 43 can be pressed directly into from the first chamber 41 to third under pressure and be led to
In road 82.In some preferred modes, the second chamber 42 can be directly assembled on third channel 82.In some preferred modes
In, third channel 82 and third chamber 43 have shared opening, but when being loaded into sample, and being will be slightly note that just will not allow sample
Originally it enters in third channel 43.In some preferred modes, when initial collection sample, in order to make provision against emergencies, third channel
43 can be closed, such as be clogged with plug, or sealed with film.
In some preferred modes, some apertures that can be connected to the first chamber, these apertures are arranged in the bottom of third chamber
It can be opened under certain conditions, these apertures are only connected to the first chamber and third chamber, without with other cavitys or outside
Portion's connection.In some preferred modes, the bottom of third chamber is arranged in these apertures.In some preferred modes, these
Aperture is arranged on the wall surface that the first chamber and third chamber share.In some preferred modes, these apertures are that pressure port 83 connects
Logical, when in third chamber 43 by enough pressure, pressure port 83 will be opened, and the first chamber and third chamber is allowed to can be realized fluid
Connection, sample directly can enter the first chamber from third chamber at this time, and when pressure is removed, pressure port 83 can restore closure again.
In some preferred modes, pressure port can be using foregoing self-enclosed aperture, such as opening similar to " bottle of screaming "
Mouthful.In some preferred modes, pressure port in closed state, is able to bear the liquid pressure for carrying out third chamber under state of filling
Power, that is to say, that be only to the intracavitary loading sample of third, the self weight of these samples is not enough to open pressure port.Some excellent
In the mode of choosing, when sample reaches certain collecting amount, pressure port can be opened.In some preferred modes, pressure port
The pressure that can bear can configure according to actual needs.In a specific embodiment, the section of the first chamber 41 compares third
The section in channel 82 is wide, can make have a distance between third channel 82 and the first chamber 41 in this way, pressure port 83 is set
It sets in this section apart from upper.In some preferred modes, the pressure in third chamber 43 may come from lid, such as lid
It is pushed down on equipped with piston and perhaps squeezes upper liquid level or cover cap is fashionable can produce pressure, act on liquid level.
Detect entrance
Detection entrance 46 is the communication port between collecting chamber and detection zone, yet it is not desirable to will test region and collection
The connection of chamber moment, collecting chamber can be separated with detection zone, and be connected to as needed, in such a case, it is possible to detecting
Entrance 46 setting detection entrance partitions 54, by detection entrance partitions 54 come realize detection entrance 46 can be adjusted or
It is set as the function of being connected to or separate, thus can according to need and the liquid in third chamber 43 is introduced into detection zone 45
It is interior.
For example, detection entrance partitions 54 has certain hardness and thickness in mode as shown in figure 27, which is provided with
Notch is interference fit between the section of notch, then in the case where no pressure or insufficient pressure, entire notch is
State in closure, can separate liquid communication, but in the case that the side of notch is under pressure, and notch will be along
The direction of pressure is opened wide, and nature pressure release is carried out, that is to say, that when there is a certain amount of sample in the side of notch, or is applied to sample
Add certain pressure, so that it may wash notch open, make 45 fluid connection of collecting chamber and detection zone, after pressure is removed, notch
It can restore the state of closure again.
Detection zone
Detection zone 45 the utility model be for liquid sample carry out analysis test with the presence or absence of analyte
Matter.It generally, may include testing element inside detection zone 45, the testing element and liquid sample carry out contact and carry out to liquid
The chemical examination or test of body sample.In traditional product, generally when manufacture has the device of test chamber, typically
It first makes testing element or testing element is allowed to be arranged on carrier, then testing element is inserted into detection zone again, so
Sealing detection region again afterwards.In this case, generally there is detection zone an opening testing element can be entered and left to inspection
It surveys in region.Such as shown in Fig. 1-2,20-21, the upper end of detection zone 45 is equipped with a testing element entrance 65, such as preceding institute
It states, testing element can be allowed to be inserted into detection zone 45 by this testing element entrance 65.Under normal conditions, it is inserted into
After test chamber, need to be sealed the opening 65 of detection zone, this sealing effect and quality requirement are very high, as front
It is illustrated, entire detection device or collection device require to carry out transportation and packaging together, in order to avoid being located at detection zone
The liquid in domain or the liquid of third chamber are unlikely to reveal, and need strictly to seal any place there may be leakage,
And each product requires the detection of being sealed property, increases production cost in this way.But use the utility model
After the second chamber with secondary-confirmation, these were considered with the place for needing sealing effect good can not have to deliberately go to examine in the past
Consider, this sealing only needs temporary sealing with regard to much of that, and does not need to require persistent sealing.Such as shown in Figure 24-25,
Can be using lid 66 be tightly connected for the sealing of collection port 49 and testing element entrance 65, being tightly connected lid 66 includes for covering
Firmly the first lid of sample collection entrance 67 and the second lid 68 for covering testing element entrance 65 pass through the first lid 67 and the second lid
68, can simultaneously collection port 49 and testing element entrance 65 be covered by being tightly connected lid 66, and the sealing for being tightly connected lid 66 is just adopted
With conventional sealing can, such as the first lid 67 and the second lid 68 be engaged by clamping in the opening of third chamber and detection zone
Portion.Other than mode shown in figure, thermoplastic envelope can also be carried out with film, as long as guaranteeing when detection, the film
Sealed air-tight or no leakage can, after completing detection, after allowing the second chamber to separate with apparatus main body, apparatus main body
(including detection zone) can make discard processing, without entire detection device is stored and transported.Some preferred
In mode, the connecting portion 69 with lid cooperation that can also be arranged as shown in figures 24-25 is tightly connected on lid 66, some excellent
In the mode of choosing, connecting portion 69 can be using threaded connection, such as form shown in figure, and certainly, connecting portion 69 can also
With connection in any other form, as long as can be realized the connection for being tightly connected lid 66 and lid 63.Certainly, close
Envelope connection cover 66 can also be used as the lid of device in itself, does not need connecting portion 69 at this time, but will directly be tightly connected and cover
66 are made into the shape that can seal whole device.
For collecting the second chamber of confirmation detection sample
In some specific embodiments of the utility model, the utility model provides a kind of for collecting confirmation detection sample
This second chamber 42.In some preferred modes, the second chamber 42 can be collected with initial detecting sample with a batch of sample,
That is, can also be packed into the second chamber 42 with a batch of sample while acquiring initial sample.Some preferred
In mode, the sample in the second chamber 42 is from the first chamber 41.In some preferred modes, the sample in the second chamber 42 is come from
Third chamber 43.In some preferred modes, the second chamber 42 can directly collect sample.
As the specific implementation of the second chamber, as shown in figs. 12-15, the second chamber 42 is the cavity of a variable-volume,
This cavity has an open end 55, and in some preferred modes, open end 55 cannot be compressed, and as shown in figure 13, open
An opening is equipped in mouthful end 55, this opening 56 can with when the second chamber 42 be connected to other cavitys to pass through other cavitys
Collecting sample or this opening can permit the second chamber 42 and voluntarily collects sample.In some preferred modes, this is opened
Mouthfuls 56 can be sealed by sealing element 57, as shown in figure 14, when being sealed by sealing element, sealing element 57 can be connected with opening 56,
Close-fitting or removable connection or combination.In some preferred modes, the mode of communicating of linker 58 and the second chamber 42 be can be
57 are punctured with puncturing elements to realize.
In some preferred modes, open end 55 can also be compressed, in such a case, it is possible to not be separately provided close
Open end and the second chamber 42 are directly integrally formed by sealing, or setting can be with the compressed sealing together of open end 55
Part, the elasticity or retractility that sealing element needs to have certain at this time.
In some preferred modes, the second chamber 42 can have the opening of a self-sealing, as previously mentioned, this is open
It is at the state of sealing over a range of pressures, it is ensured that the liquid in the second chamber 42 will not flow out, but in pressure
More than certain numerical value, it is likely that can open, after the pressure for being more than this numerical value is removed, and the state of sealing can be restored to.
In some preferred modes, sealing element 57 can be rubber stopper or plastic plug or silica gel plug, have material
It with certain elasticity, can be connected to by puncturing elements with extraneous or other cavitys when being punctured, when puncturing member
After part is removed, and it can restore to seal, the sealing after recovery can guarantee within the scope of certain pressure, and liquid therein will not
Leakage.
In some preferred modes, it can be evacuated in the second chamber 42, in this way, since the second chamber 42 does not have internal pressure,
Once being connected to other cavitys or the external world, there will be conducive to sample to flow into the second chamber 42.
In some preferred modes, the second chamber 42 its shape and volume after being loaded into liquid sample can change,
As depicted in figs. 18-19, after the second chamber 42 is loaded into a certain amount of liquid sample, shape from it is flat expansion be it is cylindric.
Since the second chamber 42 has such retractility or elasticity, and its open end is punctured element and punctures when being packed into sample, because
When need to use, can squeeze the second chamber 42 makes it from the opening for being punctured element and puncturing to the sample being packed into this second chamber 42
End outflow.
In some preferred modes, the second chamber is also possible to hard cavity, for example, by using glass or plastic material system
At the opening for capableing of self-sealing can be set on sealing element 57, for example, the opening of similar " bottle of screaming ".In some preferred sides
In formula, the opening of self-sealing be can be arranged directly on the second chamber.
Linker
As shown in figs. 9-11, in some specific implementations of the utility model, the utility model also provides a kind of use
In the linker 58 of connection the second chamber 42 and the first chamber 41.In some preferred modes, linker 58 and the second chamber 42 are removable
The connection or combination of formula.In some preferred modes, when cavity is connected or combined with linker, linker can be incited somebody to action
Inside cavity is connected to other cavitys or outside liquid.In some preferred modes, when cavity and linker are dismantled, chamber
Body is in the state of self-sealing.In some preferred modes, linker 58 is used to be connected to the second chamber 42 and other cavitys, such as
First chamber 41 or third chamber 43.In some preferred modes, linker 58 is empty for being connected to the second chamber 42 and outside
Between.
As shown in figure 9, linker 58 can have a puncturing elements 59, this puncturing elements 59 can be in certain external force
The second chamber 42 is punctured under effect, and establishes one and other cavitys or the extraneous channel being connected to for the second chamber 42.Some excellent
In the mode of choosing, puncturing elements 59 are syringe needles as shown in the figure.
In some preferred modes, linker 58 has a connection chamber 60, and puncturing elements 59 are connected to chamber 60 is connected to,
Connection chamber 60 itself can be connected to other cavitys, for example, connection chamber 60 can be connected to the first chamber 41, when the first chamber 41 is squeezed
When pressure, in sample can be entered in the second chamber 42 by connection chamber 60 along puncturing elements 59, in some preferred sides
In formula, connection chamber 60 can also be used as the entrance for directly collecting sample.
In some preferred modes, connection chamber 60 can be by the receiving of 47 part of first passage wherein, this part is especially
It is a kind of assembly method of linker and first passage, in this assembly side as shown in figure 36 including collecting tank 50 noted earlier
Under formula, linker separates first passage and third chamber 43, and first passage is made to be merely able to the second chamber 42 of connection and the first chamber 41, this
When the second chamber 42 can only receive the sample from the first chamber 41, this mode is particularly suitable for the intracorporal sample of other chambers and is used as inspection
The case where survey, it is ensured that entering the sample in the second chamber 42 as secondary detection will not be contaminated when initial detecting, together
When by first passage and third chamber partition after, the outer periphery of the second chamber will not be by the sample contamination from third chamber, in the second chamber
It completes after collecting and taking out, outer surface will not be infected with sample.
In some preferred modes, a position limiting structure can be set for linker 58 and lid 63, this limit knot
Structure can prevent linker 58 to be brought away from lid, because the outer wall of linker 58 may be in contact with sample, in this feelings
Under condition, when the second chamber 42 is removed, linker 58 had better not be carried over simultaneously with the second chamber 42, otherwise have sample,
That is the separation of the second chamber of Yao Shixian 42 and linker 58, this separation can pass through limit while the second chamber 42 takes out
Bit architecture limits the movement of linker to realize.In some preferred modes, position limiting structure be can be set on lid 63.?
In some preferred modes, position limiting structure be can be set on linker 58.
In some preferred modes, there is a step surface 61 on the end face of linker 58, step surface 61 can be used as
Linker 58 covers on a datum level on first passage 47, also, after the second chamber completes sample collection, linker 58 due to
The effect of puncturing elements 59 can be connected on the second chamber 42, need to separate in the second chamber and linker 58 at this time, Ye Jixu
Apply certain external force, but since linker itself has been infected with by sample, cannot be manually operated, in this case, by
It, can effect by the assembling structure 62 of the second chamber on lid 63 to this step surface 61 in the protrusion of step surface 61, it is ensured that
In the separation of the second chamber 42, linker 58 is still remained in device, will not be pulled out therewith.In addition, also having on linker 58
One tapered surface 64, the main function of tapered surface are easy for the installation of linker 58.
As shown in Figure 3-4, in a specific embodiment of the utility model, linker 58 is initial in use, can
To be installed in the lower end of the assembling structure 62 of the second chamber on lid 63, as the lid trap of lid 63 is on first passage 47.?
It is initial to use or when initial assembly, linker 58 is not connected to the second chamber, only when needing to collect secondary-confirmation detection
Sample when, linker 58 just can be connected to the second chamber under the action of certain.
Such as state shown in Fig. 7-8 and 36, it is the state that linker 58 is not yet connected to the second chamber 42, the second chamber at this time
Liquid sample is not yet collected into 42, under this mated condition, by matching relationship or external force by linker 58 to second
The direction of chamber 42 pushes, then the puncturing elements 59 on linker 58 can puncture the outer wall of the second chamber or puncture on the second chamber
Sealing element 57 and the second chamber fluid connection.For another example state shown in Figure 19, it can be understood as be that linker 58 is extracted from the second chamber
State, the second intracavitary liquid sample for being collected into sufficient amount at this time extracts linker 58 at this time, and the second chamber is punctured outer
The sealing element 57 of wall or the second chamber can Natural closure, the state of this Natural closure is able to bear in its collected liquid
The pressure of body sample.It needs in use, squeezing the second chamber, liquid sample can be flowed out from the place of being punctured.
Lid
As seen in figures 3-6, in some specific embodiments of the utility model, the utility model provides a kind of lid
63, in some preferred modes, as shown in Fig. 2, lid 63 can connect on being tightly connected lid 66, lid 63 and sealing
Connection cover 66 can be removable by connecting portion 69 combination or connection, that is to say, that lid 63 can cover conjunction sealing
In connection cover 66, it can also be removed from thereon.In some preferred modes, it can be not provided with being tightly connected lid 66, lid 63
Directly lid closes the oral area in third chamber 43, lid 63 can also and third chamber 43 the removable combination or connection of oral area, when
It, can be by the sample collection device integral sealing of the utility model when the lid of lid 63 closes.As previously mentioned, it is this sealing can be it is general
Logical sealing is also possible to more demanding sealing structure, is selected according to actual demand.
In some preferred modes of the utility model, lid 63, can be by the second chamber 42 while sealing cooperation
Be packed into so that the second chamber 42 be in one being capable of the position of collecting sample or state at any time.Certainly, the utility model is not arranged
Except in some preferred modes, the second chamber 42 can also be placed in other way can at any time the position of collecting sample or
Person's state.In some preferred modes, the assembling structure 62 of the second chamber is set, the second chamber 42 can be with the assembly on lid 63
The removable connection of structure 62 perhaps combination before the device of the utility model is used (such as transport storage or sale
When) the second chamber 42 can be separated with assembling structure 62, if this separation can reduce shared by the utility model overall structure
Then when in use space, then the second chamber 42 is encased in assembling structure 62, the second chamber can be filled with assembling structure
Enter to suitable position.In some preferred modes, setting assembly channel 70,62 energy of assembling structure of the second chamber on lid 63
Enough and removable the assembly channel 70 combinations or connection, that is to say, that the second chamber can be loaded into the assembling structure first
It is interior, then be encased in lid 63 by the assembling structure.
In some preferred modes, linker 58 can be also loaded into assembling structure 62, but linker 58 is packed into
Assembling structure 62 is not offered as it and is directly connected to the second chamber 42, and as previously described, linker 58 can be according to actual use
Need under other mating reactions perhaps external force with 42 fluid connection of the second chamber or separate.
The assembling structure of second chamber
In some preferred modes of the utility model, the utility model provides a kind of assembling structure 62 of second chamber,
The main function of the assembling structure 62 is to be packed into the second chamber wherein, in some preferred modes of the utility model, second
Chamber 42 is a flexible body, and outer wall can be extruded, and the second chamber needs and the either other cavity progress of lid can
Tearing the combination of formula open, perhaps connection will necessarily apply the second chamber certain during this removable combination or connection
External force, if none external protection structure to this flexible body of the second chamber, it is more likely that can exert a force it is improper will wherein
Liquid sample squeeze out, this is the case where absolute demand avoids, therefore assembling structure is not only the second chamber of carrying, also to the second chamber
Play the role of a support and temporarily protects.
In some preferred modes, the second chamber is also possible to hard cavity, such as glass or plastic material are made,
In this case, assembling structure can also play a certain protective role the second chamber, and more important is play one to second
The convenient mode that chamber is grabbed, held.
In some preferred modes, as shown in Fig. 7,16-17, assembling structure has an outer wall 71 and inner cavity 72, the
Two chambers can be loaded into its inner cavity, the second chamber and inner cavity can using secure bond, be fixedly connected or removable combination can
The form for tearing formula connection open is assembled together.The purpose of assembly be enable the second chamber and assembling structure as a whole with lid
Body or other cavitys and component are attached or combine.As previously mentioned, assembling structure 62 needs to play branch to the second chamber
The effect of support and protection, therefore, the outer wall of assembling structure 62 must have certain a shape and hardness, this shape will be beyond the
The outline shape range of two chambers, hardness, which will meet, is able to bear certain pressure without causing to squeeze to the second chamber, such as finger
Extruding will not deliberately go to squeeze when in use since the working environment of the second chamber is usually all mobile or manual operation
Second chamber or assembling structure, therefore the requirement to hardness will not be too high, the hardness of common plastic material substantially energy
Enough meet this requirement.
It, may be by way of squeezing its outer wall since the second chamber is when discharging sample in some preferred modes
It realizes, some engraved structures 73 is set on the outer wall of assembling structure, these engraved structures 73 can be passed through, the second chamber is carried out
It squeezes.In some preferred modes, due to there is the presence of engraved structure 73, assembling structure itself can bear a certain range
Interior extrusion deformation needs to be, as long as squeezing assembling structure, to apply pressure to the second chamber by assembling structure when discharging sample,
Also can achieve the purpose that sample is discharged.
In some preferred modes, assembling structure 62 is equipped with the matched fixed ring in open end 55 of one and the second chamber
74, the outer wall of open end 55 is fixedly connected with the inner wall of the fixed ring 74, in conjunction with or removable connection or combination, thus
Second chamber is fixed in assembling structure.In some preferred modes, fixed ring 74 and open end 55 be respectively positioned on the second chamber and
The lower end of assembling structure.
In some preferred modes, assembling structure 62 and the removable combination or connection of lid 63.Some preferred
Mode in, assembling structure 62 is equipped with an assembling connecting piece 75, assembling connecting piece 75 can and the removable combination of lid
Or connection, in some preferred modes, assembling connecting piece 75 combination or connection removable by screw thread and lid 63,
In other preferred modes, assembling connecting piece 75 can also be connected by other dismountable connection types with lid
It connects.
In some preferred modes, in order to which the separation and loading of the second chamber are convenient, as shown in figs. 16-17, assembling structure
62 are equipped with a knob 76, as shown in Figure 1-3, knob 76 is to be exposed to after assembling structure is loaded on lid 63
The outer surface of lid, assembling structure and the second chamber can be taken out by rotating backward knob 76, it should be noted that knob
76 only a kind of possible implementation, in fact, the concrete implementations such as handle, plectrum, link form can realize it is this
Function can be exposed to the outer surface of lid as long as there is an element, and convenient for the loading and separation of the second chamber, this is practical
The novel concrete form for not limiting this element.
In some preferred modes, the sealing element 57 of the second chamber can be fixed in assembling structure 62, such as setting exists
At fixed ring 74, perhaps it is arranged outside fixed ring 74 or other can be connected to inside the second chamber 42 across sealing element 57
On position.
First passage
In some preferred modes, first chamber of the utility model be not directly have external collection port, but
Liquid sample is received by other chambers, such as third chamber 43, in this case, is between the first chamber and third chamber
The state of fluid connection.In some preferred modes, the first chamber is directly connected to third chamber.In some preferred modes,
First chamber is connected to third chamber by a first passage 47, and as can be seen in figures from 27 to 29, the effect of first passage 47 is to make first
Chamber and third chamber realize that fluid connection, fluid can enter the first chamber from third chamber by the first passage.Such as the institute in figure
In the mode shown, this first passage 47 is located at the bottom of third chamber 43, in this way, entering the intracavitary sample of third can be
Naturally it is intracavitary that first is flowed under the action of self gravity.First passage 47 is directly connected to third chamber 43, also, the first chamber 41
Positioned at the lower section of third chamber 43, third chamber 43 has a upward collection port 49, and by the collection port 49, liquid sample can be with
It enters in third chamber 43 and falls naturally under the effect of gravity or toward flowing down, fall and enter naturally that portion of first passage
Point liquid sample can be fallen directly into the first chamber 41, in natural dropping process some inevitable liquid sample be can not be straight
It connects and falls into first passage 47, then this partially liq sample can gather in the bottom of third chamber 43, when liquid level is more than
When being higher by the height of 43 bottom of third chamber from first passage 47, this partially liq will be flowed into first by first passage 47
In chamber 41.In some preferred modes, sample can also enter third chamber from the first chamber.
In some preferred modes, for example, as can be seen from the figure, it can be opened up on the side wall of first passage 47
One collecting tank 50, this collecting tank 50 can be flushed with the bottom of third chamber 43 or the bottom of slightly above third chamber, certainly
In right dropping process and does not enter the part liquid sample of first passage 47 and can finally be pooled to the bottom of third chamber 43, due to
Relatively, the liquid sample in 43 bottom of third chamber may pass through greatly collection to the bottom level of collecting tank and third chamber 43 very much
Slot 50 enters in first passage 47 to be flowed into the first chamber 41 along first passage 47.It should be noted that due to me
Do not need sample all in third chamber 43 and be all flowed into the first chamber 41, it is only necessary to a part therein, therefore, only
The amount for the liquid to be collected into is enough, will necessarily some sample can enter in first passage 47, also, due to actually making
In, entire cavity may be in the state of a nonstatic, such as be held, then the collected sample of institute also due to
It rocks and more possibly enters in collecting tank 50 greatly.
In some preferred modes, first passage 47 can be closed, such as in the first intracavitary sample to the second chamber
When middle transfer or the second chamber are removed and are put into, since the second chamber is the liquid sample for collecting secondary-confirmation detection
, when first passage is closed, the first chamber and third chamber are in liquid partition state, for example, in some preferred modes,
Sample initially enters third chamber, and can flow into the first chamber along first passage above-mentioned, and the first intracavitary liquid can be in outer masterpiece
Entered under it is second intracavitary, in some preferred modes, when the first chamber and the second chamber are in the state of fluid connection, first
Channel can be closed.In some preferred modes, as shown in figure 36, first passage can be closed by linker,
Under this assembly method, linker separates first passage and third chamber 43, and first passage is made to be merely able to connection 42 He of the second chamber
First chamber 41, the second chamber 42 can only receive the sample from the first chamber 41 at this time, and this mode is particularly suitable in other cavitys
Sample the case where being used as detection, it is ensured that enter in the second chamber 42 as the sample of secondary detection will not initial detecting when
It waits and is contaminated, while by after first passage and the partition of third chamber, the outer periphery of the second chamber will not be dirty by the sample from third chamber
Dye, after the second chamber is completed to collect and take out, outer surface will not be infected with sample.
4th chamber
In some preferred modes, the utility model provides a kind of the 4th chamber for temporary detection sample, such as Figure 27-
Shown in 28, the 4th intracavitary sample is mainly used for primary detection.It is directly intracavitary to sample from the 4th in some preferred modes
It is detected.In some preferred modes, the 4th intracavitary sample is pushed into detection zone and is detected.Some excellent
In the mode of choosing, the 4th chamber can directly collect sample.In some preferred modes, the 4th chamber can pass through other chambers
Collect sample.
When the 4th chamber collects sample by other chambers, in some preferred modes, the 4th chamber can be with third chamber
State in fluid connection or partition.In some preferred modes, when the 4th chamber and third chamber are in fluid connection state
When, the liquid of the intracavitary collection of third can enter the 4th chamber simultaneously, and the 4th chamber can also be with third chamber in initial collection sample
When be at the state of connection, for example, the 4th chamber is located at the bottom of third chamber as shown in Figure 27-28, the bottom of third chamber is set
There is the opening being connected to the 4th chamber, in this way, the liquid sample for entering third chamber can flow directly under the effect of gravity
Four chambers, the 4th chamber can also substantially simultaneously complete required sample with third chamber.In some preferred modes, the 4th
Chamber can be directly connected to third chamber.In some preferred modes, the 4th chamber can pass through second channel and third chamber liquid
Connection.
In some preferred modes, the 4th chamber can be in the state of fluid connection or partition with detection zone, when
When initial collection, the 4th chamber can be isolated with detection zone to come four chambers, that is to say, that collects and detection can be
Mutually independent link.In some preferred modes, the 4th chamber and the isolation of detection zone be connected to can by detect into
It mouthful realizes.As previously mentioned, detection entrance 46 is the communication port between collecting chamber and detection zone, yet it is not desirable to will test
Region is connected to the collecting chamber moment, and collecting chamber can be separated with detection zone, and be connected to as needed, in this case,
It can realize that detection entrance 46 can be with by detection entrance partitions 54 in the detection setting detection entrance partitions 54 of entrance 46
It is adjusted or is set as the function of being connected to or separate, thus can according to need and be introduced into the liquid in third chamber 43
In detection zone 45.
For example, detection entrance partitions 54 has certain hardness and thickness in mode as shown in figure 27, which is provided with
Notch is interference fit between the section of notch, then in the case where no pressure or insufficient pressure, entire notch is
State in closure, can separate liquid communication, but in the case that the side of notch is under pressure, and notch will be along
The direction of pressure is opened wide, and nature pressure release is carried out, that is to say, that when there is a certain amount of sample in the side of notch, or is applied to sample
Add certain pressure, so that it may wash notch open, make 45 fluid connection of collecting chamber and detection zone, after pressure is removed, notch
It can restore the state of closure again.
In some preferred modes, when the 4th chamber 44 is in fluid connection state with detection zone 45, the 4th chamber 44
It is in liquid partition state with third chamber 43, on the one hand may insure the pollution shadow that detection zone not may cause by other chambers
It rings, quantitative detection on the other hand may be implemented, as long as the volume of the 4th chamber of setting, so that it may realize to the sample for entering detection zone
This is quantified.
Second channel
As previously mentioned, the effect of second channel 48 is that the 4th chamber 44 and third chamber 43 is made to realize fluid connection, to make the
Four chambers 44 can be with 43 synchronous collection sample of third chamber.In some preferred modes, it is contemplated that this part sample itself will be kept away
Exempt from pollution, this part sample will avoid existing with the intracorporal sample contact of other chambers and this part sample when detection
The problem of contact the testing element of detection zone not flow back later, when the 4th intracavitary sample is transferred to detection zone
When, second channel is also closed simultaneously.For example, state as shown in figure 28, the initial position of the second liquid relief element 53 is in
The side of 48 lower section of second channel, during the 4th chamber 44 collects sample, the location of second channel is constant, works as needs
When sample is pushed into detection zone, the second liquid relief element 53 is mobile to the direction close to detection zone 45, at this time and one by
Gradually close the process of second channel 48.In some preferred modes, the distance between second channel 48 and detection zone are less than
The length of second liquid relief element 53 itself, in this way, second channel 48 is still within by the second liquid relief element after completing liquid relief
53 closed states.
First liquid relief element, the second liquid relief element, pipetting channel and liquid relief plug
The utility model provides liquid relief element, and the effect of liquid relief element is to make the liquid in the first chamber 41 into the second chamber 42
Transfer.In some preferred modes, liquid relief element can also be such that the liquid in the 4th chamber 44 shifts to detection zone 45, above-mentioned
Two kinds of transfers can be synchronous, be also possible to mutually independent process.
In some preferred modes, as shown in Figure 27-29,31-34, liquid relief element includes for will be in the first chamber 41
Sample is transferred to the first liquid relief element 52 in the second chamber 42, and, the sample in the 4th chamber 44 is transferred to detection zone 45
The second liquid relief element 53, the first liquid relief element 52 and the second liquid relief element 53 independently can move or link, and first moves
Liquid element 52 and the second liquid relief element 53 are usually to be pushed mobile and then generate thrust to the intracorporal liquid of respective chamber, make these
Sample is transferred in other cavitys or region.For example, the first liquid relief element 52 can move to squeeze under external force
The sample in the first chamber 51 is pressed, pressure is generated to it, shifts it to required direction or chamber, such as passes through company
It is intracavitary that logical device 58 enters second.In some preferred modes, the second liquid relief element 53 can move under external force from
And the intracorporal sample of the 4th chamber 44 is squeezed, pressure is generated to it, shifts it to required direction or chamber, such as
It enters in detection zone 45.
In some preferred modes, the first liquid relief element 52 and the first chamber 41 are in same pipetting channel 51, are pushed
Above-mentioned extruding may be implemented in first liquid relief element.In some preferred modes, the second liquid relief element and the 4th chamber are in same
In one pipetting channel, push the second liquid relief element that above-mentioned extruding may be implemented.In some preferred modes, the first liquid relief member
Part, the second liquid relief element, the first chamber and the 4th chamber are in same pipetting channel 51, push the first liquid relief element or the second liquid relief
One of element can be realized simultaneously above-mentioned extruding, and in this case, the first liquid relief element and the second liquid relief element can
To realize the state to link step by step, such as in the case where the first liquid relief element is pushed, the first liquid relief element stress first is moved
It is dynamic, the first intracavitary sample is squeezed, the mobile resistance of the second liquid relief element is likely larger than the resistance that the first intracavity liquid is moved,
The first intracavitary sample is preferentially transferred at this time, when the first intracavitary sample is discharged to the first liquid relief element to the second liquid relief member
When the active force of part is greater than the second liquid relief element mobile resistance, the second liquid relief element starts to squeeze the 4th intracavitary sample, makes
It obtains the 4th intracavitary sample to be also transferred, alternatively, the second liquid relief element is pushed in other possible situations, second is moved
Liquid element stress first is mobile simultaneously to squeeze the 4th intracavitary sample, at this point, the mobile resistance of the first liquid relief element is likely larger than the
The resistance that four intracavity liquids are moved, the 4th intracavitary sample are preferentially transferred, when the 4th intracavitary sample is discharged to second
When liquid relief element is greater than the first liquid relief element mobile resistance to the active force of the first liquid relief element, the first liquid relief element starts to squeeze
The first intracavitary sample is pressed, so that the first intracavitary sample is also transferred.In some cases, it is intended that, when the first liquid relief
Element and the second liquid relief element are under foregoing linkage status, and the first intracavitary liquid is preferentially transferred, then the 4th chamber
Interior liquid just breaks through the entrance of detection zone, this be in order to ensure first it is intracavitary be transferred to the second intracavitary liquid sample will not
Contaminated when detection, certainly, the transfer of the first chamber and the 4th chamber can also synchronize progress, due to there is one in structure
Along the sequence of liquid flow direction, therefore a possibility that reflux or pollution, is smaller.
In some preferred modes, fluid connection or partition is may be implemented in pipetting channel and the second chamber.Some preferred
Mode in, fluid connection or partition may be implemented in pipetting channel and detection zone.In some preferred modes, the first liquid relief
Pipetting channel pipetting channel is divided into the first chamber and the 4th chamber by element and the second liquid relief element.In some preferred modes,
Second liquid relief element separates the 4th chamber and the second chamber, in fact, from figure it can also be seen that in some preferred modes,
First chamber and the 4th chamber are two sections in pipetting channel.
In some preferred modes, when the first intracavitary sample be transferred to second it is intracavitary when, the volume of the first chamber with
Diminution.In some preferred modes, when the volume-diminished of the first chamber, the first liquid relief element and the second liquid relief element are therewith
It draws close.In some preferred modes, when the 4th intracavitary sample is transferred in test zone, the volume of the 4th chamber is therewith
It reduces.Fluid connection in some preferred modes, after the first intracavitary liquid is transferred, between the first chamber and the second chamber
State is separated.Liquid in some preferred modes, when the 4th intracavitary liquid is transferred, between the 4th chamber and third chamber
Body connected state is separated.In some preferred modes, it is by second that the connected state of the 4th chamber and third chamber, which is separated,
Liquid relief element closes second channel to realize in moving process.
Another feature of the utility model is that quantitative detection may be implemented.For example, in some preferred modes, the
The initial volume of four chambers is fixed, that is to say, that in the 4th chamber stress by before compressing, the amount of the 4th intracavitary sample that can be packed into
It is confirmable.In some preferred modes, initial position of the second liquid relief element in pipetting channel is fixed.Some
In preferred mode, the initial volume of the first chamber is fixed, that is to say, that in the first chamber stress by before compressing, the first intracavitary energy
The amount for the sample being enough packed into is confirmable.In some preferred modes, the first liquid relief element is first in pipetting channel
Beginning position is fixed.In some preferred modes, the first liquid relief element and the second liquid relief element are relatively first in pipetting channel
Beginning position is fixed.
In some preferred modes, pipetting channel has a liquid relief opening 77, can be to liquid relief by liquid relief opening
Apply external force in channel, realizes above-mentioned extruding.In some preferred modes, liquid relief opening can by the first liquid relief element or
Second liquid relief element is sealed.In some preferred modes, liquid relief element further include can push the first liquid relief element and/or
The liquid relief plug of second liquid relief element.In some preferred modes, liquid relief plug can be open by liquid relief and be protruded into pipetting channel.
In some preferred modes, the opening of pipetting channel the first liquid relief element and/or second is moved by some preferred modes
Liquid element is equipped with and the matched socket of liquid relief plug.
In some preferred modes, sealing element 76, sealing element 76 are equipped between liquid relief element and pipetting channel 51
It can be sealing ring as shown in figure 35, sealing ring can be made of the material with certain elasticity, it is ensured that liquid relief element exists
It, will not there is a situation where samples to reveal between liquid relief element and the inner wall of pipetting channel when being moved in pipetting channel.Sealing member
Part 76 is exactly the frictional force increased between liquid relief element and pipetting channel inner wall there are one effect, in enough friction masterpieces
Under, to the intracavitary loading fluid low of the first chamber and the 4th so that liquid relief element is subjected to displacement, so that it may realize quantitative collection
And quantitative detection.
As shown in Figure 31-32, in a specific embodiment, the first liquid relief element 52 includes a first movement chamber
79, power part such as liquid relief plug 78 can partially protrude into push the first liquid relief element 52 in this mobile cavity 79, corresponding
, a tapering also can be set in liquid relief plug 78, this cavity can provide the point of application for power part, while can also be certain
The direction of promotion is limited in degree.In some preferred modes, first movement chamber 79 can also be not provided with.Some preferred
In mode, the first liquid relief element 52 is equipped with support leg 80, and support leg 80 can separate the first liquid relief element 52 and the second liquid relief
Element 53, it is ensured that there are certain spaces always between two liquid relief elements.In some preferred modes, the first liquid relief element
On can also be not provided with support leg.In some preferred modes, the first liquid relief element is equipped with seal groove 81, sealing element 76
It is mounted in seal groove 81.Seal groove 81 can be one or multiple tracks.
As shown in Figure 33-34, in a specific embodiment, the second liquid relief element 53 includes second mobile cavity
82, power part, which can partially protrude into, pushes the second liquid relief element 53 in this mobile cavity 82, thus by the 4th intracavitary sample
It is pushed into detection zone, is the state that the 4th intracavitary sample is driven fully into detection zone as shown in figure 29.Some excellent
In the mode of choosing, the second mobile cavity 82 can also be not provided with.
The method for collecting liquid sample
The utility model provides a kind of method for collecting liquid sample, and this method is filled using foregoing sample collection
It sets, which includes the first chamber for collecting liquid sample and the second chamber for collecting confirmation detection sample,
First chamber and the second chamber are at the state of fluid connection or partition, when the first chamber and the second chamber are in fluid connection state
When, it is intracavitary that the first intracavitary liquid can be transferred to second.
It further include the third chamber for collecting sample, third chamber and the first chamber can be in some preferred modes
One chamber is in the state of fluid connection or partition, and the collection of initial sample can be carried out by third chamber, and first is intracavitary collected
It is intracavitary for secondary detection purposes may to be transferred to second for the sample arrived.
In some preferred modes, when the first chamber and third chamber are in fluid connection state, the intracavitary collection of third
Liquid can enter the first chamber simultaneously, that is to say, that third chamber carry out sample initial collection when, first it is intracavitary while
The sample of initial collection can be packed into.
In some preferred modes, when the first intracavitary liquid be transferred into second it is intracavitary when, at the first chamber and third chamber
Separate state in liquid, since the second intracavitary sample is detected for secondary-confirmation, not in order to ensure the second intracavitary sample
It is contaminated, just the first chamber is isolated with other chambers before transfer.
It further include the 4th chamber for collecting sample to be detected in some preferred modes, the 4th chamber can be with third
Chamber is in the state of fluid connection or partition.
In some preferred modes, when the 4th chamber is in fluid connection state with third chamber, the intracavitary collection of third
Liquid can enter the 4th chamber simultaneously, and the 4th chamber can also be at the shape being connected to when initial collection sample with third chamber
State, such 4th chamber can also substantially simultaneously complete required sample, the 4th intracavitary collected sample with third chamber
Originally it is mainly used for primary detection, primary detection can also can be transferred to other by the 4th chamber directly in the 4th intracavitary progress
Region carries out, such as detection zone.
Further include detection zone in some preferred modes, the 4th chamber can be in detection zone fluid connection or
The state of partition, when the 4th chamber is when initial collection, the 4th chamber can be isolated with detection zone to come, that is to say, that
Collection and detection can be independent from each other link.
In some preferred modes, when the 4th chamber is in fluid connection state with detection zone, the 4th chamber and third
Chamber is in liquid partition state, on the one hand may insure the pollution effect that detection zone not may cause by other chambers, another
Quantitative detection may be implemented in aspect, as long as the volume of the 4th chamber of setting, so that it may realize and determine the sample for entering detection zone
Amount.
In some preferred modes, the second chamber and third chamber can be combined or be separated.In some preferred modes,
Second chamber and the first chamber can be combined or be separated.Due to the second chamber be need to get from the first chamber or third chamber it is collected
Sample, therefore the second chamber must with the first chamber or third chamber or one of them establish the relationship of fluid connection, when obtaining
After having got required sample, the second chamber has to be independent sealed and save cavity therein again, or even will be by independence
It is transported, is sent to secondary detection mechanism, therefore the second chamber has to and the first chamber or third chamber or one of them point
From, in some preferred modes, the second chamber can with the first chamber or third chamber or one of them removable combination or
Person's connection.
It further include the communication apparatus between the first chamber and the second chamber, communication apparatus first in some preferred modes
Intracavitary sample enters second and intracavitary provides advantageously channel and a path.
In some preferred modes, when initial collection sample, communication apparatus is not installed in place, need into
When row secondary-confirmation is collected, then communication apparatus is installed.
In some preferred modes, communication apparatus can allow the first chamber and the second chamber to be in the state of fluid connection can also
The connected state of the first chamber and the second chamber to be separated.
In some preferred modes, communication apparatus can separate the connected state of the first chamber and third chamber.When initial
It is pollution-free in order to ensure secondary-confirmation sample after the completion of the collection of sample, first the first chamber and third chamber can be separated.
In the present invention, since can not to enter second naturally intracavitary for initial collected sample, it is necessary to pass through
Under certain external force, in this case, just have to take initial collected sample certain active force.
Therefore, in some preferred modes, the method for the utility model also provides a kind of liquid relief element, in initial collection
After the completion, the first intracavitary sample for having had sufficient amount squeezes the first intracavitary sample then pushing liquid relief element at this time
Pressure makes it direct or through communication apparatus and enters second intracavitary, and simultaneously, the volume of first chamber itself is compressed.?
In some preferred modes, liquid relief element can also be shifted the 4th intracavitary sample.In some preferred modes, the
The transfer of four intracavitary samples can be after the first intracavitary sample transfer.In some preferred modes, the first chamber and the 4th chamber
Different liquid relief elements can be respectively adopted to be squeezed.In some preferred modes, the liquid relief member of the first chamber and the 4th chamber
It may be implemented to link between part.
In some preferred modes, the method for the utility model also provides pipetting channel, and above-mentioned liquid relief element can
It is moved in pipetting channel, to squeeze the first chamber or the 4th intracavitary liquid.In some preferred modes,
First chamber or the 4th chamber can be a certain section in pipetting channel, be separated to form chamber by different liquid relief elements
Body.In some preferred modes, the first chamber can realize fluid connection with the second chamber.In some preferred modes, the 4th
Chamber can realize fluid connection with detection zone.That is, inherently can be with the second chamber or detection as pipetting channel
Region or the two connection.
In some preferred modes, the method for the utility model also provides a kind of liquid relief plug, and liquid relief plug is mainly used for
Mobile power is provided to liquid relief element, keeps it mobile to the first chamber and/or the 4th intracavitary sample in pipetting channel
The power squeezed is generated, these samples are shifted.
In some preferred modes, the method for the utility model also provides the sealing between liquid relief element and pipetting channel
Structure, it is ensured that when liquid relief element stress is mobile, gap will not be generated between the inner wall of pipetting channel, sample will not occur
Leakage.
Sample testing method
The utility model provides a kind of method for detecting and whether there is analyte in liquid sample, the detection method
Sample collection device including any one above-mentioned mode collects sample to be detected by sample collection device, to the 4th
After intracavitary collection has sample, sample therein is detected.In some preferred modes, there is sample to the intracavitary collection of third
Afterwards, sample therein is detected.In some preferred modes, the 4th intracavitary sample is transferred to detection zone to it
It is detected.In some preferred modes, the intracavitary sample of third is transferred to detection zone, it is detected.Deng acquisition
After testing result, the second chamber is allowed to be separated according to above-mentioned arbitrary mode with sample collection device.
One specific embodiment
As shown in Fig. 2, the sample collection device of the utility model may include lid 63 and third chamber 43, lid and third
Chamber passes through the removable connection of connecting portion 69.Sample collection device can also include some components, these components are using
Before can be the individually state, such as the second chamber 42, assembling structure 62, linker 58, liquid relief plug 78 etc. do not assembled, these zero
Part can be loaded into third chamber 43 in transportation and packing, on the assembly channel of lid 63, can be pre-configured with a plug,
For clogging assembly channel, prevent dust stratification or assembly channel interior contaminated.In some cases, linker 58 can also be made
For a components, refills be fitted on lid when in use.In use, plug is removed, the second chamber 42 is then assembled to lid
In the assembly channel of body 63, second chamber itself be may be mounted in an assembling structure, this assembling structure and the second chamber are formed
One assembly, this assembly are encased in the assembly channel of lid 63, and linker 58 is then also built into assembly again and is led to
The lower end in road 70, linker 58 can will assemble the lower end closed in channel, before use, as shown in figure 36, linker 58 is not
The second chamber can be punctured.In some cases, linker 58 can be the assembly the bottom of the channel for being pre-assembled in lid 62, but
It is the extreme position for not being assembled to cooperation.
When collecting sample, lid is opened, according to above-mentioned relation by the component assemblings to lid such as the second chamber, then to third
Intracavitary collection sample, while third intracavitary collection sample, sample can automatically flow into, Zhi Daoda intracavitary to the first chamber and the 4th
To required amount, then lid 63 is closed, during lid sealing, linker 58 can close first passage first, so
Rear cover body continues to close to lower cover, then assembling channel can push, and enters further into linker in assembly channel, until puncturing the
Sealing element 57 on two chambers, first passage is closed by linker at this time, and the first chamber and third chamber are in isolation, and the first chamber
Fluid connection state is in by linker with the second chamber, but since linker is connected by syringe needle, first is intracavitary
Liquid is to be located at the lower section of the second chamber, therefore the first intracavitary liquid will not actively flow into the second intracavitary, the 4th intracavitary sample again
Originally it will not actively flow into detection zone.
When detecting sample, the first liquid relief element 52 is inwardly pushed by liquid relief plug 78, the first liquid relief element 52 is inside at this time
The mobile volume that can make the first chamber 41 become smaller, squeeze the first intracavitary liquid sample, it is mobile to the second chamber to make it, while also can
Inside thrust is generated to the second liquid relief element 53, but overcomes the second liquid relief element 53 and liquid relief logical in this inside thrust
Before frictional resistance between 51 inner wall of road, the second liquid relief element 53 be all it is motionless, until the first liquid relief element 52 and second
Liquid relief element 53 is in contact, and the second chamber has been substantially finished the collection of sample at this time, further inwardly pushes liquid relief plug, and second moves
Liquid element 53 starts to squeeze the 4th intracavitary liquid sample, pushes it into detection zone, is detected by testing element, such as
State shown in 29 is that the 4th intracavitary sample is pushed fully into detection zone.Since the position of the second liquid relief element 51 is first
It is it is believed that therefore the volume of the 4th chamber 44 is it is believed that realize quantitative detection under beginning state.
In the mode of the present embodiment, testing element can be placed in detection zone, by testing element come to sample
Initial detecting is carried out, detection zone is made of transparent material, can observe directly test by the outer surface of detection zone
As a result, needing to carry out secondary-confirmation detection when test result may be positive or weakly positive or in the case where can not determining
When, by turning knob 76, the second chamber and assembling structure are taken out, linker stays in detection device at this time, and the second chamber can
It is detected with being independently transported to secondary-confirmation testing agency.
Claims (20)
1. a kind of collecting chamber of sample, characterized in that including the third chamber for initial collection sample, third bottom of chamber portion is equipped with energy
Enough first passages with the first chamber fluid connection, the sample of the intracavitary collection of third can be naturally flowed by first passage to the
One is intracavitary.
2. a kind of collecting chamber of sample according to claim 1, characterized in that first passage is located at the bottom of third chamber.
3. a kind of collecting chamber of sample according to claim 1, characterized in that first passage can be closed or open.
4. a kind of collecting chamber of sample according to claim 1, characterized in that the side wall of first passage is equipped with a receipts
Collect slot, this collecting tank is flushed with the bottom of third chamber or the bottom of slightly above third chamber.
5. a kind of collecting chamber of sample according to claim 4, characterized in that collecting tank can individually be closed or and
First passage is closed simultaneously.
6. a kind of collecting chamber of sample according to claim 1, characterized in that further include for collecting sample to be detected
4th chamber, the 4th chamber can be in the state of fluid connection or partition with third chamber.
7. a kind of collecting chamber of sample according to claim 6, characterized in that the sample of the intracavitary collection of third can be natural
Ground be flowed into it is the 4th intracavitary, alternatively, can be flowed into the 4th under certain external force intracavitary for the sample of the intracavitary collection of third.
8. a kind of collecting chamber of sample according to claim 6, characterized in that cavity includes for making the 4th chamber and third
The second channel of chamber fluid connection.
9. a kind of collecting chamber of sample according to claim 8, characterized in that second channel can be closed or open.
10. a kind of collecting chamber of sample according to claim 1, characterized in that including pipetting channel and liquid relief element.
11. a kind of collecting chamber of sample according to claim 10, characterized in that liquid relief element is by one in pipetting channel
Part is divided into the first chamber.
12. a kind of collecting chamber of sample according to claim 10, characterized in that liquid relief element can be in pipetting channel
The mobile volume to change the first chamber.
13. a kind of collecting chamber of sample according to claim 12, characterized in that liquid relief element can be intracavitary to first
Sample applies active force to which the first intracavitary sample is transferred to other cavitys or outside.
14. a kind of collecting chamber of sample according to claim 12, characterized in that liquid relief element can be intracavitary to first
Sample applies active force to which the first intracavitary sample is transferred to other cavitys or outside from first passage.
15. a kind of collecting chamber of sample according to claim 14, characterized in that when sample is shifted from first passage, the
One channel is isolated with third chamber.
16. a kind of collecting chamber of sample according to claim 11, characterized in that liquid relief element includes the first liquid relief element
With the second liquid relief element, pipetting channel is isolated into the first chamber and the 4th chamber by the first liquid relief element and the second liquid relief element.
17. a kind of collecting chamber of sample according to claim 16, characterized in that the first liquid relief element and the second liquid relief member
Part can move in pipetting channel.
18. a kind of collecting chamber of sample according to claim 17, characterized in that the first liquid relief element can press when mobile
Contract the first chamber, shifts liquid therein by first passage.
19. a kind of collecting chamber of sample according to claim 17, characterized in that the second liquid relief element can press when mobile
Contract the 4th chamber.
20. a kind of collecting chamber of sample according to claim 19, characterized in that the 4th chamber of the second liquid relief compression element
Meanwhile closing second channel.
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CN2018101504850 | 2018-02-13 | ||
CN201810150485 | 2018-02-13 | ||
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CN2018210430334 | 2018-06-29 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110426509A (en) * | 2019-07-29 | 2019-11-08 | 杭州博拓生物科技股份有限公司 | A kind of detection device |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110426509A (en) * | 2019-07-29 | 2019-11-08 | 杭州博拓生物科技股份有限公司 | A kind of detection device |
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