CN215575183U - Detection device - Google Patents

Abstract

The utility model discloses a detection device which comprises a first cavity for collection, a second cavity for detection and a first channel for communicating the first cavity with the second cavity, wherein an adjusting element is arranged in the first channel and is configured to be used for adjusting communication or sealing between the first cavity and the second cavity. The adjusting element comprises a connecting piece, one end of the connecting piece is connected with a first plunger, and the connecting piece is configured to be capable of being used for blocking communication between the first passage and the first cavity. The detection device is a complete set of detection device, samples can be collected and can be detected, the whole detection process does not need to be in direct contact with the samples, the excrement solution is sealed in the detection device in the detection process, the whole device is good in sealing performance, the liquid leakage phenomenon cannot occur, and the automatic detection by a user is facilitated.

Description

Detection device

Technical Field

The utility model relates to a detection device.

Background

In the field of medical biology, analytical testing of samples is the basis for numerous tests and treatments. Stool testing is commonly used for early screening of many diseases. Excrement is a common solid sample, excrement occult blood detection can early warn of digestive tract abnormality, and when the amount of bleeding in the digestive tract is less, the appearance of excrement is not changed abnormally and can not be identified by naked eyes. Therefore, fecal occult blood examination is required for patients suspected of having chronic gastrointestinal bleeding, the early screening of gastrointestinal malignant tumors (such as gastric cancer, colorectal cancer, polyps and adenomas) is significant, fecal occult blood detection is one of important technologies for early diagnosis of colorectal cancer and population screening, and a fecal occult blood positive person performs colonoscopy, so that the tumor detection rate can be improved by 4-6 times, and the method is the best method for screening high risk groups of colorectal tumors at present. A plurality of large-scale cohort studies prove that the colorectal cancer incidence and mortality of people can be obviously reduced by detecting fecal occult blood every year. Fecal occult blood detection has been recommended as the most important colorectal cancer screening technology by a plurality of authoritative organizations such as American cancer society, early colorectal cancer treatment projects of the national ministry of health of China, and digestive disease division of the Chinese medical society.

In the conventional fecal occult blood detection, a subject needs to take feces for inspection and then the feces are detected by professional personnel in hospitals. However, because of the high requirements for storing and transporting the collected and sent samples of the feces, and the inconvenience of people who attend physical examination in hospitals, they often choose to ignore or not to send the feces. Therefore, in actual population screening and physical examination, the feces sampling and examination rate is low.

The colloidal gold immunity test paper on the market is very simple to detect fecal occult blood, is similar to the early pregnancy test paper, can be completely detected by community residents at home and judges the result by the community residents. But are reluctant to look directly or touch feces due to their strong odor. Secondly, the feces are solid and need to be fully dissolved in the buffer reagent before the detection of the immune test paper can be carried out. Again, control of stool sampling volume is difficult. Finally, the excrement is not leaked after being dissolved in the buffer reagent in the detection operation, otherwise, the excrement is not suitable for household or non-specialized household detection.

At present, no instrument suitable for fecal occult blood self-detection exists in the market, some fecal occult blood reagent manufacturers are respectively provided with some excrement collectors, but the excrement collectors do not have sampling amount control devices and do not comprise detectors, and all detections are performed under open conditions. Therefore, fecal occult blood is limited to be carried out in a professional medical institution at present, a professional generally places quantitative fecal into a container with a buffer reagent for dissolving when detecting, then pours the fecal liquid in the container into a small cup or a small hole, then inserts a liquid absorption test strip into the small cup or the small hole for detecting, according to the colloidal gold immunochromatography principle, the mixed liquid contacts with the test strip in the kit for running, a color band appears, and according to the contrast of the color depth of the color band and a standard color card, the fecal occult blood is negative or positive. The excrement solution is open in the detection process, corresponding sealing measures are not provided, the frequency of direct vision of excrement is high, a small cup and a small hole are prone to overturn and overflow and leak liquid in operation, the operation is carried out with gloves, detection devices are not scattered in a set and are inconvenient to carry and transport, and the defects enable the occult blood of the excrement to be incapable of being measured by non-professionals at present.

At present, for the feces, a sample with the pollution property, operators have the requirement of safety and sanitation and are inconvenient to directly contact. Some excrement detection device include sealing element, but the leakproofness of whole detection device remains to be improved, and detection device structural design is comparatively complicated for detection operation is inflexible.

Most excrement detection devices on the market cannot control the amount of collected samples, and some detection devices need to be controlled by detection personnel according to own experience and working habits; in addition, the conventional feces detection device cannot control the amount of sample solution which enters the detection region and runs on the detection element. However, in the detection process, the control of the amount of the collected sample and the amount of the sample solution often has a great influence on the detection result. If the control is not good, the detection result is inaccurate.

SUMMERY OF THE UTILITY MODEL

In view of the above situation, the present invention provides a detection device to overcome the drawbacks of the prior art.

In order to achieve the purpose, the utility model provides the following technical scheme:

a detection device comprises a first cavity for collection, a second cavity for detection and a first channel for communicating the first cavity with the second cavity, wherein an adjusting element is arranged in the first channel and can be used for adjusting communication or sealing between the first cavity and the second cavity.

Further, the adjusting element comprises a connecting piece, one end of the connecting piece is connected with a first plunger, and the connecting piece is configured to be capable of being used for blocking communication between the first passage and the first cavity.

Further, the other end of the connecting piece is connected with a second plunger which is configured to block the communication between the first passage and the outside.

Further, the cross-sectional dimension of the connecting member is smaller than the cross-sectional dimensions of the first plunger and the second plunger.

Further, the surfaces of the first plunger and the second plunger are both provided with pits.

Further, a first sealing element is arranged at the pit. The first sealing element can adopt a sealing ring, so that the sealing effect is good, the first channel is well separated from the outside or/and the first cavity, the first channel cannot be communicated with the outside and the first cavity, and the leakage of the sample solution cannot exist.

Further, a pushing piece is connected to the outer end of the second plunger.

Further, the pushing piece is provided with an opening. In some preferred modes, the opening is one-way and cannot be communicated with the first channel, the opening is arranged to facilitate grabbing of the pushing piece and pulling or pushing of the pushing piece outwards, the opening can reduce the weight of the whole adjusting element, and the opening can be distinguished from other parts to indicate that the opening is the pushing piece and can be used for adjusting communication or partition between the first cavity and the second cavity.

Further, one end of the first channel is provided with a first opening configured for enabling communication with the first cavity, and the other end of the first channel is provided with a second opening through which the adjustment element can enter the first channel.

Further, the bottom surface of the first channel is provided with a third opening through which the second cavity can be communicated.

Further, the first passage is of a cylindrical structure. Compared with other square channels, the channel with the cylindrical structure enables the adjusting element to be tightly combined with the first channel, and the sealing performance is better; and the frictional force of adjusting element and first passageway inner wall is less, can not frictional damage adjusting element like this, and the adjusting element of being convenient for slides in first passageway, be convenient for change the position of adjusting element in first passageway, and then change the connected state between first chamber and the second chamber (connected state means to communicate between first chamber and the second chamber or by the wall), if the passageway of first passageway for square passageway or other shapes, make the frictional force between adjusting element and the first passageway inner wall relatively great like this, adjusting element can not smoothly move in first passageway, make the accommodation process comparatively hard waste time, and easy wearing and tearing adjusting element, influence the leakproofness of whole device.

Further, a lug is arranged on the outer side of the bottom of the first channel and can be matched and connected with other components. For example, after the cup body is combined with the base, the bump is contacted and combined with the stop block on the base (ultrasonic welding or thermal welding connection is available), and a certain space is left between the first channel and the bottom surface of the base due to the existence of the bump to serve as a transitional storage structure.

Furthermore, the second cavity (i.e. the detection cavity) is positioned at one side of the detection device, the first channel and the adjusting element are positioned at the other side of the detection device, the first channel and the adjusting element are positioned outside the detection cavity and are not in direct contact with the detection cavity, and a transition storage structure is arranged in the middle; therefore, in the process of pushing or pulling the adjusting element to enable the first cavity and the second cavity to be communicated or isolated, the sample solution in the detection cavity cannot shake. In the existing detection device, the adjusting element is located inside the detection chamber, so that the sample solution in the detection chamber is disturbed (or stirred) during adjustment, and the detection result is inaccurate.

Further, the bottom of the cup body is provided with a plurality of yielding structures for being matched and connected with the base, and after the cup body is combined with the base, a relatively flat surface is formed, so that the detection device is placed stably, and the transportation and storage of the detection device are facilitated. After the cup body is combined with the base, the outer surface of the second cavity is a flat surface, so that the detection result can be conveniently scanned.

Further, the inside guide structure that is equipped with of cup, guide structure connect inside detection device, and guide structure can be used for guiding the sampling head to get into first chamber or extract from first chamber, and guide structure's setting makes the sampling head can get into first chamber smoothly.

Further, the guide structure comprises a guide surface and a second channel, and the guide surface is connected with the second channel.

Further, the inner wall of the second channel is provided with a second sealing element, the second sealing element can adopt a sealing ring, and the sealing ring is fixedly connected with the second channel and can be used for sealing the first cavity and isolating the first cavity from being communicated with other parts of the device. After upper cover and cup lid closed, the sampling head was located first chamber, and sample collector's connecting rod part is located the second channel, and connecting rod and sealing washer combine closely, and the part of first chamber and guide structure top is separated, avoids the sample in the first chamber and/or buffer reagent to leak, and after upper cover and cup lid closed, the sampling head can be fixed simultaneously, avoids the sampling head to rock in first chamber. Generally need rock detection device, make the sample on the sampling head break away from the sampling head, fully contact with the buffer reagent in the first chamber, make sample solution in-process, because, first chamber is separated with other parts, sample and buffer reagent can not leak, can not influence the detection, can not influence the accuracy of testing result yet.

Furthermore, the guide surface is sunken downwards, so that the sampling head can smoothly and quickly enter the second channel and then enter the first cavity, the time is saved, and the efficiency is improved.

Further, the spigot surface makes the sampling head can get into the second passageway along the cambered surface downwards for the cambered surface like this, gets into first chamber, and the sampling head contacts with the cambered surface, can not wear and tear, fish tail sampling head, if the spigot surface is the plane of buckling, probably can wear and tear, harm the sampling head.

Further, the side of the mounting adjacent the side wall is provided with a fourth opening for the adjustment element to enter the first passage, and in some preferred forms a guard is provided around the fourth opening. In some preferred modes, the protecting piece protrudes outwards from the fourth opening, and the protecting piece can protect the first channel and the adjusting element placed in the first channel and avoid damage to the first channel and the adjusting element during transportation, storage and the like.

Further, when the detection device is in an initial state (i.e. when the detection device is not used), the pushing member is flush with the outer end of the protection member, the first cavity is isolated from the first channel, and the first cavity is not communicated with the second cavity, so that an operator can be reminded: when the push member of the adjustment element is flush with the outer end of the protection member, the first chamber and the second chamber are blocked. During the use process of the device, the pushing piece is pushed to move towards the direction of the inner part of the detection device. When the pushing part of the adjusting element cannot further enter the first channel, the pushing part can be felt to be clamped at the inlet of the first channel, and the first cavity is communicated with the second cavity, so that an operator can be reminded to understand the state (the communicated state or the isolated state) between the first cavity and the second cavity. According to the utility model, the adjusting element is flexible to operate, and can be conveniently adjusted to enable the first cavity and the second cavity to be in a communicated state or a closed state.

The utility model has the beneficial effects that:

(1) the detection device is a complete set of detection device, samples can be collected and can be detected, the whole detection process does not need to be in direct contact with the samples, the excrement solution is sealed in the detection device in the detection process, the whole device is good in sealing performance (the cup body is tightly combined with the base, the cup body is tightly combined with the cup cover, the second sealing element is arranged at the guide structure, the first sealing element is arranged on the adjusting element), liquid leakage is avoided, and the detection is convenient for a user to detect automatically.

(2) According to the utility model, the sample collector is matched with the guide structure, a certain amount of sample can be collected, so that a sample solution with a certain solubility can be obtained, the adjustment element is matched with the first channel for adjustment, the first cavity and the second cavity can be better communicated or separated, the amount of the sample solution entering the detection cavity can be controlled, a certain amount of the sample solution enters the detection cavity, and the detection result is more accurate.

(3) In the utility model, the adjusting mode of the adjusting element matched with the first channel is flexible, (for example, the adjusting element is pushed inwards or pulled outwards, so that the communication and the separation between the first cavity and the second cavity can be realized, and corresponding marks can be provided to remind or prompt an operator that the first cavity and the second cavity are in the communication state or the separation state during adjustment, for example, when a pushing piece of the adjusting element is flush with the outer end part of the protection piece, the first cavity and the second cavity are separated, when the pushing piece of the adjusting element can not further enter the first channel, the pushing piece can be felt to be clamped at the inlet of the first channel, and the first cavity and the second cavity are communicated), so that the operation is convenient, and in the whole adjustment process, the leakproofness is better, can avoid sample solution or the solution after the detection to leak to the outside and leak to other cavities.

(4) In the utility model, after the cup body is combined with the base, the outer side surface of the second cavity (namely the detection cavity) forms a flat surface, so that the detection device is convenient to place, store and carry, and after the detection is finished, the detection result is convenient to scan.

(5) According to the utility model, a second cavity (namely a detection cavity) is positioned at one side of a detection device, a first channel and an adjusting element are positioned at the other side of the detection device, the first channel and the adjusting element are positioned outside the detection cavity and are not in direct contact with the detection cavity, and a transition storage structure is arranged in the middle; therefore, in the process of pushing or pulling the adjusting element to enable the first cavity and the second cavity to be communicated or isolated, the sample solution in the detection cavity cannot shake. In the existing detection device, the adjusting element is located inside the detection chamber, so that the sample solution in the detection chamber is disturbed (or stirred) during adjustment, and the detection result is inaccurate.

Drawings

FIG. 1 is a schematic view of the structure of the detecting device of the present invention.

FIG. 2 is an exploded view of the test device of the present invention.

Fig. 3 is a schematic view of the front of the cup (showing the structure of the first and second strips).

Fig. 4 is a schematic view of the structure of the back of the cup body.

Fig. 5 is a schematic view of the internal structure of the cup (a portion of the cup is hidden to show the guide structure).

Fig. 6 is a schematic view of the construction of the cup (showing the construction of the first channel).

Fig. 7 is a schematic structural diagram of a sample collector.

Fig. 8 is a schematic view of the structure of the sample collector (showing the structure inside the upper cover).

Fig. 9 is a schematic structural view of the base.

FIG. 10 is a schematic view of the structure of the regulating member (showing the structure of the opening on the pusher).

Fig. 11 is a schematic view of the structure of the regulating member (showing the first sealing member).

Fig. 12 is a schematic view of the structure of the adjustment element (showing the structure of the first and second plungers).

Fig. 13 is a schematic sectional view of the detecting device when the first chamber and the second chamber are separated.

Fig. 14 is an enlarged view of the lower structure of the detecting unit in fig. 13 (showing the structure of the first passage and the regulating member and the relative positional relationship therebetween).

Fig. 15 is a schematic view of the detecting unit in a sectional view (the first sealing member is not shown) in a state where the first chamber and the second chamber are communicated with each other.

Fig. 16 is an enlarged view of the lower structure of the detecting unit in fig. 15 (showing the structure of the first passage and the regulating member and the relative positional relationship therebetween).

Detailed Description

The technical solutions of the present invention are further described in detail below with reference to the accompanying drawings, and it should be noted that the detailed description is only for describing the present invention, and should not be construed as limiting the present invention.

First, technical terms related to the present invention are explained with reference to examples, and the terms are explained to enable those skilled in the art to more accurately understand the technical solution of the present invention, and do not necessarily limit the scope of the present invention.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or a metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Sample(s)

The test device or collected sample of the present invention comprises a biological fluid (e.g., a medical fluid or a clinical sample). Liquid or liquid samples, or fluid samples, may be derived from solid or semi-solid samples, including fecal, biological tissue and food samples. The solid or semi-solid sample may be converted to a liquid sample by any suitable method, such as mixing, triturating, macerating, incubating, dissolving, or enzymatically digesting a solid sample in a suitable solution (e.g., water, phosphate solution, or other buffered solution). "biological samples" include samples derived from animals, plants and food, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures, cell cultures and media of tissues and organs derived from humans or animals. Preferably, the biological sample is urine, and preferably, the biological sample is saliva. Food samples include food processing materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a waste liquid sample). Environmental samples may also include sewage or other wastewater.

Any analyte may be detected using a suitable detection element or test element. Preferably, the detection device of the utility model is used for detecting drug small molecules in saliva and urine. Of course, any of the above forms of samples, whether initially solid or liquid, may be collected using the collection device of the present invention, provided that the liquid or liquid sample is absorbed by the absorbent member. Absorbent members herein are generally made of a water-absorbent material that is initially dry and capable of absorbing a liquid or fluid sample by capillary or other properties of the absorbent member material. The absorbent material may be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, nonwoven fabric, cotton, polyester film, yarn, and the like. The absorbent member need not be made of absorbent material, and may be made of non-absorbent material, but rather, the absorbent member may have holes, threads, cavities, and samples may be taken from such structures, typically solid or semi-solid samples, that are filled between the threads, the holes, or the pores.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flows from upstream to downstream regions. The downstream region receives liquid from the upstream region, and liquid may also flow along the upstream region to the downstream region. This is generally done in terms of the direction of liquid flow, e.g., on materials that are urged to flow by capillary forces, which may flow against gravity, and in this case, upstream and downstream, again in terms of the direction of liquid flow.

Gas or liquid communication

By gas or liquid communication is meant that liquid or gas can flow from one place to another, possibly guided by some physical structure during the flow. By physical structures is generally meant that the liquid flows passively or actively to another place through the surface of the physical structures or the space inside the structures, and passively is generally a flow caused by an external force, such as a flow under capillary action. The flow here can also be a liquid or a gas, because of its own effect (gravity or pressure), or a passive flow. Communication herein does not necessarily mean that a liquid or gas is required to be present, but merely that in some cases a connection or condition between two objects, if any, may flow from one object to the other. This refers to a state in which two objects are connected, and conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a state of non-communication, non-liquid or gas communication.

Detection element

The term "detection element" as used herein refers to an element that can detect whether or not a sample or specimen contains an analyte of interest, and such detection can be based on any technical principle, including immunology, chemistry, electricity, optics, molecular, nucleic acid, physics, and the like. The detection element may be a lateral flow test strip which detects a plurality of analytes. Of course, other suitable sensing elements may be used with the present invention.

Various sensing elements may be combined for use in the present invention. One form is a test strip. Test strips for the analysis of analytes, such as drugs or metabolites indicative of a physical condition, in a sample may be in various forms, such as immunoassay or chemical assay forms. The test strip may be used in a non-competitive or competitive assay format. The test strip generally includes a bibulous material having a sample application area, a reagent area, and a detection area. The sample is added to the sample application zone and flows by capillary action to the reagent zone. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for displaying the detection signal is present in the reagent zone or in a separate label zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains the analyte and no signal is generated if the analyte is not present. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The detection element can be detection test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength when the test strip is held in place.

The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The substance that produces the signal (or the signal species) can be on the sample addition zone, the reagent zone, or the detection zone, or the entire test strip, and the substance can be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal substance was added was dried.

The various regions of the test strip may be arranged as follows: the device comprises a sample adding area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be a material with good water absorption such as filter paper, nitrocellulose membrane, etc. The test strip may take other forms.

A commonly used reagent strip is a nitrocellulose membrane reagent strip, i.e., a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display the detection result; and may be a cellulose acetate film, a nylon film, or the like. Such as the reagent strips or devices containing the reagent strips described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The test strips disclosed in the above patent documents and similar devices with test strips can be applied to the detection element or the detection device of the present invention for detecting an analyte, such as an analyte in a sample.

The test strip used in the present invention may be a so-called Lateral flow test strip (Lateral flow test strip), and the specific structure and detection principle of these test strips are well known to those skilled in the art. A typical test strip comprises a sample collection area or application area, a labeling area comprising a label pad, a detection area comprising a bibulous pad, and a bibulous area comprising the necessary chemicals to detect the presence of the analyte, such as immunological or enzymatic reagents. A commonly used detection reagent strip is a nitrocellulose membrane reagent strip, that is, a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display a detection result; it may be a cellulose acetate film, a nylon film, etc., and it may also include a detection result control region downstream of the detection region, and usually, the control region and the detection region are in the form of a transverse line, which is a detection line or a control line. Such test strips are conventional, but other types of test strips that utilize capillary action for testing are also contemplated. In addition, typically, the test strip has a dry chemical reagent component, such as an immobilized antibody or other reagent, which when exposed to a liquid, flows along the test strip by capillary action, and as it flows, the dry reagent component is dissolved in the liquid, and the next zone is processed to react the dry reagent in that zone, thereby performing the necessary test. The liquid flow is mainly by capillary action. The detection device can be used in the detection device of the present invention, or can be disposed in the detection chamber to contact the liquid sample, or can be used to detect the presence or quantity of an analyte in the liquid sample entering the detection chamber.

In addition to the test strips described above or the lateral flow test strip itself being used to contact a liquid sample to test for the presence of an analyte. In some preferred forms, the test element may also be provided on a carrier having a plurality of recesses in which the test element is located. In some embodiments, the carrier includes a recessed area for receiving the test element, and a plurality of recesses are provided in the recessed area, each of which can receive a test strip, and each of which can detect an analyte. In some embodiments, after the test element is disposed in the recess of the carrier, the carrier is covered with a transparent film, which seals the recess region of the carrier and facilitates observation of the test result on the final test region. The transparent film may also be a transparent plastic sheet.

Typically, the test strip includes a sample application region, a labeling region and a detection region, the sample application region being positioned adjacent to the bottom of the carrier and slightly exposing the recess, for example 2-3 mm, when the test strip is placed, with a portion of the sample application region reserved to absorb fluid sample flowing into the bottom of the collection chamber. Typically, the sample application zone is located upstream of the labeling zone, which is located upstream of the detection zone.

Such carriers are useful for carrying test strips in applications where these particular carriers may be used in the test chamber of the present invention as part of the test, such as described in DE19780221T1, JP1999506213A, US7244392, US 20040133128A.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs of abuse (e.g., drugs of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. Abuse of these drugs can result in physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americane, white amphetamine tablets, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep-aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofballs, barbs, blue devils, yellow jacks, hypnones); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline and doxepin); dimethyldioxymethylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine, or opiates, cocaine, COC; heroin, dihydrocodeinone); anxiolytic and sedative hypnotic, anxiolytic is a kind of mainly used for relieving anxiety, stress, fear, stabilize mood, have hypnotic sedative effects at the same time, including benzodiazepine BZO (benzodiazepines), atypical BZ, fuse dinitrogen NB23C, benzodiazepine, BZ receptor ligand, ring-opening BZ, diphenylmethane derivatives, piperazine carboxylate, piperidine carboxylate, quinazolone, thiazine and thiazole derivatives, other heterocycles, imidazole type sedative/analgesic (such as dihydrocodeinone OXY, methadone MTD), propylene glycol derivative-carbamate, aliphatic compound, anthracene derivatives, etc.. The detection device of the utility model can also be used for detecting the detection which belongs to the medical application and is easy to take overdose, such as tricyclic antidepressant (imipramine or the like) and acetaminophen. After being absorbed by human body, the medicines are metabolized into small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

For example, analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial material (e.g., proteins or carbohydrate material directed against a specific bacterium, such as E.coli 0157: H7, staphylococci, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Cactus), and substances associated with physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical chemistry assay can be detected using a lateral flow assay format in conjunction with the device of the utility model.

Flow of liquid

The flow of liquid usually refers to a flow from one place to another, and in general, the natural liquid flow mostly depends on gravity from high to low, and the flow here also depends on external force, i.e. the flow under the external gravity condition, and can be the natural gravity flow. In addition to gravity, the flow of liquid may also move from low to high against gravity. For example, the liquid is pumped or pressed, or the liquid is pressurized and flows from a low position to a high position.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

As shown in fig. 2 and 13, a detection device comprises a first cavity 1 for collection and a second cavity for detection, wherein the first cavity 1 and the second cavity can be closed or communicated, and further comprises a first channel 40 for communicating the first cavity 1 with the second cavity, and an adjusting element 3 is arranged in the first channel 40 and can be used for adjusting the communication or the closing between the first cavity 1 and the second cavity. In some preferred forms, the adjustment element 3 is slidably connected to the first channel 14, and the adjustment element 3 can be slid in the first channel 14 by pushing the adjustment element 3 inward or pulling the adjustment element 3 outward. The different positions of the adjusting element 3 in the first channel 14 determine whether the first chamber 1 and the second chamber are in a communicating or a closed state.

In some preferred modes, first chamber 1 is located detection device inside for collect a certain amount of testing sample, testing sample and buffer reagent mixing can be made into the sample solution that can be used for the detection, in some preferred modes, can place buffer reagent in first chamber 1 in advance, when needs examine time measuring, add first chamber 1 with the sample, the sample mixes with the contact of buffer reagent, avoid adding buffer reagent in addition, add buffer reagent in addition, make detection device structure more complicated, and comparatively loaded down with trivial details in the operation. In some preferred modes, the buffer reagent is directly placed in the first cavity 1, in other preferred modes, the buffer reagent is placed in the buffer reagent containing device, the buffer reagent containing device is placed inside the first cavity 1, and when detection is needed, the buffer reagent containing device is punctured, so that the buffer reagent flows out to be in contact with and mixed with the detection sample in the first cavity 1. In some preferred forms, the buffer reagent holding means is provided with an opening which is initially closed and can be opened. In other preferred modes, the buffer reagent containing device is not provided with an opening, for example, the buffer reagent containing device is a capsule or a bag capable of storing the buffer reagent, and any place can be punctured to allow the buffer reagent to flow out. In some preferred forms, the buffer reagent may be a diluent or a solution that reduces the viscosity of the liquid sample or other functional reagent; for example, some samples may not be tested in their original state, or the test results may be unsatisfactory, and often require pre-treatment to change their physical or chemical properties, for example, by buffering the sample with a buffer to help dilute the sample and then testing the sample. In some preferred modes, a detection element is arranged in the second cavity and used for detecting the analyte in the sample to be detected.

In this embodiment, as shown in fig. 2, the detection device includes a cup 4 and a base 19, the cup 4 is connected to the base 19, in some preferred modes, the cup 4 is connected to the base 19 by ultrasonic welding, in other embodiments, the cup 4 and the base 19 can also be connected by heat welding or snapping or other connection modes. The combination of the cup 4 and the base 19, as shown in fig. 1, can be used to collect and test a sample to be tested, so that the collection and testing of the sample can be performed in one testing device, avoiding open transfer operations in the middle process, especially for special samples such as stool samples. In some preferred modes, the detection device further comprises an upper cover 29, the upper cover 29 is connected with the cup body 4 in a buckling manner, the upper cover 29 and the cup body 4 can be connected in a threaded manner or in other manners, in this embodiment, as shown in fig. 3 and 8, a clamping block 8 is arranged on the inner side surface of the upper cover 29, a clamping groove 7 is arranged on the cup body 4, and the clamping block 8 can be clamped in the clamping groove 7, so that the connection between the upper cover 29 and the cup body 4 is realized.

In some preferred modes, as shown in fig. 3, the front side surface of the cup body 4 comprises a first step 5 and a second step, the first step 5 is connected with the second step 6, the first step 5 is located above the second step 6, and a clamping groove 7 is arranged on the surface of the first step 5 and can be in snap-fit connection with a clamping block 8 on the inner side surface of the upper cover 29. In some preferred forms, as shown in fig. 6, the bottom surface of the first step 5 is provided with a mounting slot 9 for mounting in combination with other components. In some preferred manners, as shown in fig. 3, the surface of the second step 6 is connected with a first clamping strip 10 disposed opposite to the first clamping strip 10, and is further connected with a second clamping strip 11 disposed opposite to the first clamping strip 10, and the first clamping strip 10 and the second clamping strip 11 are used for clamping and fixing the detecting element 12, so that the detecting element 12 can be stably located in the second cavity, in this embodiment, the detecting element 12 is a test strip. In some preferred modes, the inner sides of the first card strip 10 and the second card strip 11 are both provided with the card contact 13, so that the combination of the detection element 12 and the first card strip 10 and the second card strip 11 can be firmer and more stable, and the detection result is prevented from being influenced by displacement and inclination of the detection element. In some preferred modes, cup 4 bottom is equipped with many places and gives way structure 50 for be connected with the base 19 cooperation, after the cup combines with the base, form more smooth surface, the detection device of being convenient for places steadily, is favorable to transportation, storage detection device. The outer surface of the second cavity is a flat surface, which facilitates scanning of the test results.

In some preferred modes, as shown in fig. 3, a first channel 14 is arranged inside the cup body 4, the first channel 14 can communicate the first cavity 1 with the second cavity, in some preferred modes, as shown in fig. 5, one end of the first channel 14 is provided with a first opening for communicating with the first cavity 1, and the other end of the first channel 14 is provided with a second opening 16 as a channel inlet for the adjusting element 3 to enter the first channel 14, so that the communication or the sealing between the first cavity 1 and the second cavity is adjusted. In some preferred forms, the bottom surface of the first channel 14 is provided with a third opening 17, through which third opening 17 the second chamber can be connected. In some preferred forms, as shown in fig. 4-5, the first passage 14 is cylindrical, this results in a low friction of the adjusting element 3 against the inner wall of the first channel 14, which does not frictionally damage the adjusting element 3, but also the adjusting element 3 can slide in the first channel 14, the position of the adjusting element 3 in the first channel can be adjusted, and the communication state between the first cavity 1 and the second cavity (the communication state refers to the communication or the separation between the first cavity 1 and the second cavity) can be changed, if the first passage 14 is a square passage or a passage of other shape, so that the frictional force between the adjusting member 3 and the inner wall of the first passage 14 is relatively large, the adjusting member 3 cannot smoothly move in the first passage 14, the adjusting process is labor-consuming and time-consuming, and the adjusting element 3 is easy to wear, so that the tightness of the whole device is affected.

In some preferred modes, the bottom of the outer surface of the first channel 14 is provided with a bump 18, the bump 18 can be matched and connected with other components, in this embodiment, as shown in fig. 13-14, after the cup body 4 is combined with the base 19, the bump 18 is combined with a stop 60 on the base 19 in a contact manner (which can be ultrasonic welding or thermal welding), and due to the existence of the bump 18, a certain space is left between the first channel 14 and the bottom surface of the base 19, and the third opening 17 is not contacted with the bottom surface of the base 19, so that the sample solution can conveniently flow into the second cavity, and the detection reaction can be favorably carried out. If the third opening 17 contacts the bottom surface of the base 19, the third opening 17 may be blocked, which is not favorable for the communication between the first chamber 1 and the second chamber and the sample solution in the first chamber 1 flowing into the second chamber. The first channel 14 and the bottom surface of the base 19 are provided with a certain space, which is used as a transitional storage structure 70, when the first chamber and the second chamber are in a communication state, the liquid sample can flow into the first channel from the first chamber, then enter the transitional storage structure 70 from the first channel through the third opening 17, and then enter the second chamber (i.e. the detection chamber) through the fifth opening 71. Therefore, in the process of pushing or pulling the adjusting element to enable the first cavity and the second cavity to be communicated or isolated, the sample solution in the detection cavity cannot shake. In some detection devices in the prior art, the adjusting element is located inside the detection chamber, and then, when the adjusting element is adjusted, the sample solution in the detection chamber is disturbed (or stirred), so that the detection is affected, and the detection result is inaccurate.

In some preferred forms, as shown in fig. 9, the base 19 comprises a bottom support 20 and a side wall 21, the bottom support 20 is fixedly connected with the side wall 21, the bottom support 20 can be combined with the bottom of the cup body 4, the side wall 21 is combined with the front side of the cup body 4 to form a second cavity for detecting a sample, and in some preferred forms, the upper end of the side wall 21 is provided with a raised mounting part 53, and the raised mounting part 53 can be inserted into the mounting groove hole 9 to combine the side wall 21 with the cup body 4. In some preferred forms, the side of the mounting 20 adjacent to the side wall 21 is provided with a fourth opening 54 for the passage of the adjustment element 3 into the first channel 14, and in some preferred forms, the periphery of the fourth opening 54 is provided with a protection 23 projecting outwards. The protective element 23 protects the first channel 14 and the adjusting element 3 inserted into the first channel 14 from damage to the first channel 14 and the adjusting element 3 during transport, storage, etc.

In some preferred modes, as shown in fig. 10 to 12, the adjusting element 3 includes a connecting member 22, one end of the connecting member 22 is connected with a first plunger 24, the other end of the connecting member 22 is connected with a second plunger 25, the first plunger 24 and the second plunger 25 can be used for blocking the first passage 14, so as to separate the first passage 14 from the outside or/and other cavities, for example, the first plunger 24 can be used for blocking the communication between the first passage 14 and the first cavity 1, and further blocking the communication between the first passage 14 and the second cavity, and the second plunger 25 can separate the first passage 14 from the outside, so as to prevent the sample solution in the first passage 14 from leaking, flowing out of the detection device, polluting the detection station, and affecting the detection. In some preferred forms, as shown in fig. 12, the first plunger 24 and the second plunger 25 are provided with recesses 52 on their surfaces, and a first sealing element can be disposed at the recesses 52, and the first sealing element has elasticity to be tightly combined with the recesses without being separated from the recesses. The arrangement of the first sealing element enables the first plunger, the second plunger and the first channel to be combined more tightly, and liquid leakage is avoided. The number of dimples 52 can be designed as desired. The first sealing element 26 may be a sealing ring, which enables a better sealing effect, so that the first channel 14 is better separated from the outside or/and the first cavity 1, the first channel 14 is not in communication with the outside and the first cavity 1, and there is no leakage of the sample solution. In some preferred forms, the cross-sectional dimension of the connector 22 is smaller than the cross-sectional dimensions of the first and second plungers 24, 25, thereby facilitating the entry of the sample solution into the first channel, and the sample solution can enter the second chamber through the third opening.

In some preferred forms, as shown in fig. 10-12, the outer end of the second plunger 25 is connected with a pusher 27, the pusher 27 is fixedly connected with the second plunger 25, and the pusher 27, the second plunger 25 and the whole adjusting element 3 can move in the first channel 14. In some preferred modes, as shown in fig. 10, pushing member 27 is provided with an opening 28, which is one-way and does not communicate with first channel, opening 28 is provided to facilitate grasping pushing member 27 and pulling or pushing member 27 outwards, and opening 28 is provided to reduce the weight of the whole regulating element and distinguish it from other parts, and is used to indicate that the pushing member is here used to regulate the communication or partition between first chamber 1 and the second chamber. In some preferred forms, the cross-sectional dimension of pusher 27 is greater than the cross-sectional dimension of second plunger 25 and also greater than the cross-sectional dimension of first channel 14, and pusher 27 is able to move relative to first channel 14 toward the outside of the detection device or toward the proximity device, but pusher 27 does not enter into first channel 14, and pusher 27 eventually becomes stuck outside first channel 14. In the initial state, as shown in fig. 1 and 13, the pushing member 27 is flush with the protecting member 23, the first cavity is blocked from the first passage, and the first cavity is not communicated with the second cavity, so that the operator can be reminded: when the push member of the adjustment element is flush with the outer end of the protection member, the first chamber and the second chamber are blocked. As shown in fig. 16, pushing member 27 is located at the entrance of first channel 14, and pushing member 27 has a cross-sectional dimension larger than the entrance of the first channel, so that pushing member 27 cannot enter the first channel and can not move further toward the detecting device. When the pushing part of the adjusting element cannot further enter the first channel, the pushing part can be felt to be clamped at the inlet of the first channel, and the first cavity is communicated with the second cavity, so that an operator can be reminded to understand the state (the communicated state or the isolated state) between the first cavity and the second cavity. In the utility model, the adjusting element is flexible to operate and can be conveniently adjusted to enable the first cavity 1 and the second cavity to be in a communicated state or a closed state.

During the movement of the adjusting element 3 in the first channel 14, at least one plunger is positioned in the first channel 14, so that the first cavity 1 is always isolated from the outside and not communicated with the outside, and the second cavity is always isolated from the outside and not communicated with the outside.

In some preferred modes, the detection device further comprises a sample collector 40 for collecting a sample to be detected; in some preferred modes, as shown in fig. 7-8, the sample collector 40 includes an upper cover 29, a sampling head 30 and a connecting rod 31, the sampling head 30 is connected to the connecting rod 31, the connecting rod 31 is connected to the upper cover 29, the sampling head 30 has a groove 32 for holding a sample, and the sampling head 30 may be square, triangular, hemispherical, semi-ellipsoidal, 1/3 spherical, etc., in this embodiment, as shown in fig. 7-8, the sampling head 30 is shaped like a spoon for collecting a sample and storing a sample, such as a stool sample. The sample can be collected without scratching other parts or devices. The groove 32 for accommodating the sample on the sampling head 30 is composed of a cambered surface, so that the sample can enter the groove 32 when the sample is collected. In some preferred manners, the connecting rod 31 is detachably connected with the sampling head 30, and can adopt a threaded connection or a snap-in connection, so that the sampling head 30 can be replaced or cleaned conveniently, and the connecting rod 31 can also be fixedly connected with the sampling head 30. In some preferred modes, the length of the connecting rod 31 is long, which is beneficial to quickly collecting samples, and the length is too short, which is inconvenient for obtaining samples, causes long collecting time and poor comfort of the sampling process, especially for special samples such as feces.

In some preferred modes, as shown in fig. 8, the connecting rod 31 is fixedly connected with the upper cover 29, the connecting rod 31 and the upper cover 29 are respectively connected with a reinforcing rib 33, specifically, one end of the reinforcing rib 33 is connected inside the upper cover 29, the other end of the reinforcing rib 33 is connected on the connecting rod 31, and the reinforcing rib 33 is arranged to enable the connection between the connecting rod 31 and the upper cover 29 to be firmer. During sampling, the upper cover 29 is generally required to be held by a hand to collect a sample, and at the moment, the upper cover 29 is used as a handle, so that the upper cover 29 and the connecting rod 31 are required to be firmly connected, and the phenomenon that the connection part is broken to influence the collection of the sample is avoided. In some preferred modes, the upper surface of the upper cover 29 is concave inwards, so that the area where the upper cover 29 is connected with the connecting rod 31 can be effectively protected from being collided or abraded; moreover, the concave structure is beneficial to taking or grabbing the upper cover 29, so that the upper cover is not easy to slip and not firm to grab, and the upper cover and the cup body are combined more tightly.

In some preferred modes, a guiding structure is arranged inside the cup body 4, the guiding structure is fixedly connected inside the detection device, the guiding structure can be used for guiding the sampling head 30 to enter the first cavity 1 or be pulled out of the first cavity 1, and the guiding structure is arranged to enable the sampling head 30 to smoothly enter the first cavity 1. In some preferred modes, as shown in fig. 5, the guide structure comprises a guide surface 34 and a second channel 35, the guide surface 34 is connected with the second channel 35, the guide structure divides the space in which the guide structure is located into two parts, and the part below the guide structure is a first cavity 1 for collecting a sample, mixing the sample and preparing a sample solution. The sampling head 30 can enter the second channel 35 along the guide surface 34, and enter the first cavity 1 through the second channel 35, in some preferred modes, the inner wall of the second channel 35 is provided with a second sealing element 51, the second sealing element 51 can adopt a sealing ring, and the sealing ring is fixedly connected with the second channel and can be used for sealing the first cavity and cutting off the communication between the first cavity and other parts of the device. After the upper cover 29 is covered with the cup body 4, as shown in fig. 13, the sampling head 30 is located in the first cavity 1, the connecting rod 31 of the sample collector 40 is partially located in the second channel 35, the connecting rod 31 is tightly combined with the sealing ring, the first cavity 1 is separated from the part above the guide structure, so that the sample and/or the buffer reagent in the first cavity 1 are prevented from leaking, and meanwhile, after the upper cover 29 is covered with the cup body 4, the sampling head 30 can be fixed, so that the sampling head 30 is prevented from shaking in the first cavity 1. Generally, the detection device needs to be shaken to separate the sample on the sampling head 30 from the sampling head 30 and fully contact with the buffer reagent in the first cavity 1, and in the process of preparing the sample solution, because the first cavity 1 is separated from other parts, the sample and the buffer reagent cannot leak, the detection cannot be influenced, and the accuracy of the detection result cannot be influenced.

In some preferred modes, the guiding surface 34 is concave downwards, so that the sampling head 30 can smoothly and quickly enter the second channel 35 and further enter the first cavity 1, time is saved, and efficiency is improved; if the guide surface 34 is flat or convex upward, it is not favorable for the sampling head 30 to rapidly enter the second channel 35 and enter the first cavity 1, which affects the detection operation and prolongs the operation time; in some preferred embodiments, the guide surface 34 is curved such that the sampling head 30 can move down the curve into the second channel 35 and into the first chamber 1, and the sampling head 30 contacts the curved surface without wearing or scratching the sampling head 30, which might cause wear and damage to the sampling head 30 if the guide surface 34 is a bent flat surface.

In some preferred embodiments, as shown in fig. 13, the entire guide structure has a larger upper opening and a smaller lower second opening, which facilitates the entry of the sampling head 30 into the second opening 35 and into the first chamber 1 without intentionally aligning the sampling head with the second opening; and at the in-process that sampling head 30 got into first chamber 1, can scrape off the outside sample of sampling head 30 and connecting rod 31 for only the inside sample of sampling head 30 can get into first chamber 1, can make the sample size that gets into first chamber 1 be in certain extent like this, guarantees that the sample solution that obtains after sample and the buffer reagent mix has certain concentration, makes the testing result comparatively accurate.

The utility model also provides a method of using the test device, which will now be described with reference to the embodiments of figures 1-16. As shown in fig. 13-14, the testing device is in an initial state, in which the first plunger 24 is completely located inside the first passage 14, and the first plunger 24 is provided with a sealing ring, so that the first chamber is isolated from the rest of the device; the outer surface of the pushing member 27 is flush with the outer end of the protecting member 23, and the protecting member 23 can better protect the pushing member 27 from being accidentally collided, worn, displaced and the like by the pushing member 27.

(1) Taking out the sample collector 40 and collecting a sample; specifically, the upper cover 29 is taken, and a sample is collected using the sampling head 30;

(2) inserting the sample collector 40 into the first cavity 1, contacting the sample with the Buffer reagent (Buffer) in the first cavity, and then shaking the detection device to separate the sample from the sampling head 30, so that the sample and the Buffer reagent are uniformly mixed; and after the sample and the buffer reagent are uniformly mixed, obtaining a sample mixed solution. Specifically, in the process that the sample collector 40 is inserted into the first cavity 1, the sampling head 30 scrapes off the redundant samples on the outer side of the connecting rod 31 and the outer side of the sampling head 30 through the guide structure, then the sampling head 30 enters the first cavity 1, then the fixture block 8 on the inner side surface of the upper cover 29 is clamped in the clamping groove 7 on the cup body 4, so that the upper cover 29 and the cup body 4 are covered, as shown in fig. 13-14, and then the detection device is shaken to prepare the sample solution.

(3) Pushing member 27 to move the pushing member toward the direction approaching first channel 14 until the pushing member is located at the entrance of first channel 14, at this time, the pushing member is blocked by the second opening of first channel 14 (because the size of the second opening is smaller than that of the pushing member), and cannot move further inward, as shown in fig. 15-16, at this time, first plunger 24 is separated from first channel 14, first channel 14 is communicated with first chamber 1, the sample solution in first chamber 1 can enter first channel 14, and then flow into the second chamber equipped with detecting element 12 through third opening 17 and the fifth opening, the sample solution contacts detecting element 12 to perform plate running detection, and a detection result can be obtained. The sidewall 21 may be made of a transparent material, which is convenient for an operator to observe the detection result. The amount of the sample solution entering the second chamber can be conveniently observed, for example, a scale mark is arranged on the detection device or a scale mark is arranged on the side wall of the detection device, when the amount of the sample entering the second chamber reaches a certain scale, the pushing member 27 can be pulled outwards to enable the pushing member 27 to be flush with the protection member, so that the adjusting element 3 returns to the initial state as shown in fig. 13-14, the communication between the first chamber 1 and the second chamber is isolated, the solution in the first chamber does not enter the second chamber any more, the aim of re-quantification is achieved, and the detection result is more accurate; and in this way, the undetected sample solution in the first cavity and the detection mixed solution in the second cavity are separated, and the undetected sample solution cannot be polluted. Redundant samples are stored in the first cavity, so that a user can conveniently carry the sample solution to a hospital or other professional institutions for secondary confirmation and detection.

It is to be understood that the described embodiments are merely a few embodiments of the utility model, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (8)

1. A detection device is characterized by comprising a first cavity for collection, a second cavity for detection and a first channel for communicating the first cavity with the second cavity, wherein an adjusting element is arranged in the first channel and is configured to be used for adjusting the communication or the sealing between the first cavity and the second cavity;

the adjusting element comprises a connecting piece, one end of the connecting piece is connected with a first plunger, and the connecting piece is configured to be capable of being used for blocking communication between the first passage and the first cavity;

the other end of the connecting piece is connected with a second plunger which is configured to be capable of cutting off the communication between the first channel and the outside.

2. A testing device according to claim 1 wherein the cross-sectional dimension of the connecting member is smaller than the cross-sectional dimensions of the first and second plungers.

3. A testing device according to claim 1 wherein the first and second plungers are provided with dimples on their surfaces.

4. A testing device according to claim 3 wherein the recess is provided with a first sealing element.

5. A testing device according to claim 1 wherein the second plunger has a pusher member attached to the outer end thereof.

6. A testing device according to claim 5 wherein the urging member is provided with an opening.

7. A testing device according to claim 1 wherein one end of the first passage is provided with a first opening arranged for communication with the first chamber, and the other end of the first passage is provided with a second opening through which the adjustment member can enter the first passage.

8. A testing device according to claim 1 wherein the bottom surface of the first passage is provided with a third opening through which the second chamber is accessible.

Images