CN212904922U - Sample detection device - Google Patents

Abstract

The utility model provides a sample detection device, including casing and carrier, the test element is installed to the carrier, and the casing can hold the sample, and in the carrier can insert the casing, the casing constitutes drawer type structure with the carrier, and when the carrier inserted the casing completely, test element and sample contact, test element carried out the detection of analyte nature to the sample. When the sample is collected, the absorption element can rub the oral cavity by holding the handle or the sample collector, so that the secretion of saliva is stimulated, the collection process is accelerated, and the sample acquisition amount is increased; when the sample is detected, a reagent strip or a detection device does not need to be held by hands, and the detection is finished through one extrusion action and one overturning action, so that the detection process is simplified; the assembly for integrating the collection and detection processes is one assembly, so that the detection part is simplified; the device has a simple structure and low cost, can be suitable for sample detection under crude conditions, is convenient for self-detection of people, and improves the detection rate; and detecting a plurality of analytes at a time.

Description

Sample detection device

Technical Field

The utility model relates to a short-term test field especially relates to a detection device for short-term test liquid sample.

Background

The following background description is merely an introduction to the general knowledge and is not intended to limit the invention in any way.

Currently, the technology of detecting whether an analyte exists in a sample by using the principle of an immunological binding reaction is widely used in various fields. It can be used to detect analytes in various biological samples (saliva, blood, urine, serum, sweat, etc.) to detect diseases and human health conditions (early pregnancy, tumors, infectious diseases, drugs, etc.). The underlying principle of such detection techniques is to establish the ability to specifically bind between immune molecules, such as antibodies and antigens, haptens/antibodies, biotin and avidin, and the like.

The existing saliva detection method is to collect saliva and extract saliva, and the collection of saliva and the extraction of saliva are two separate steps, so that measurement errors can be caused when procedures are switched. And when saliva is extracted, the cotton balls are basically adopted to extract saliva at present, and the problems that the saliva is difficult to extrude due to the adsorption effect of the saliva cotton balls and whether the saliva extracted by the cotton balls meets the test requirements or not cannot be judged are solved. The test paper device is generally a single test paper, and in the prior art, the single test paper is inserted into the saliva collecting bottle for detection. This detection method has the following problems: firstly, the single test paper inefficiency, secondly need artifical manual going to place the test paper, very inconvenient.

Various sample collection and testing devices for clinical use are available and described in the literature. For example, CN2018203131234 discloses a saliva detecting bottle with a double-layer structure, which is provided with an inner cylinder and an outer cylinder, wherein the inner cylinder is provided with a plurality of openings, in order to simplify the two steps of collecting saliva and extracting saliva. However, since the test strips are fixed separately, the process of installing the test strips or replacing the test strips is very complicated.

CN201210468107X discloses a saliva direct-testing device, which stimulates the secretion of saliva through a plurality of small holes, however, the device can only be used for saliva testing, and cannot test other kinds of samples, such as blood and urine.

Therefore, there is a need for a device that simplifies the steps of collecting a sample and extracting a sample and is suitable for use with a variety of samples to be tested.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a sample detection device to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the present invention provides a sample testing device, which comprises a housing and a carrier, wherein a testing element is mounted on the carrier, the housing can accommodate a sample, the carrier can be inserted into the housing, the housing and the carrier form a drawer-type structure, when the carrier is completely inserted into the housing, the testing element contacts with the sample, and the testing element performs a test on the sample for a sample.

Furthermore, a clamping groove is formed in the shell, a first protrusion is arranged on the carrier, and when the carrier is completely inserted into the shell, the first protrusion is clamped into the clamping groove.

Furthermore, a sharp corner is arranged on the clamping groove, and a first opening with a gradually reduced opening is formed at the position of the sharp corner on the clamping groove.

Further, the closed angle is provided with two closed angles, and a first opening is formed between the two closed angles.

Further, the angle of the first opening ranges from 20 ° to 160 °.

Further, a protruding table is arranged on the carrier, a recessed table is arranged on the shell, and when the carrier is completely inserted into the shell, the protruding table is arranged on the recessed table.

Furthermore, a second protrusion is arranged on the shell, a third protrusion is arranged on the carrier, and when the carrier is completely inserted into the shell, the second protrusion and the third protrusion are clamped together.

Further, the second protrusion and the third protrusion are convex arc-shaped blocks.

Further, the housing is provided with a hollow area that exposes the test elements on the carrier when the carrier is fully inserted into the housing.

Furthermore, the number of the clamping grooves is two, and the two clamping grooves are symmetrically arranged on two sides of the hollow area.

The utility model has the advantages that:

1. when the sample is collected, the absorption element can rub the oral cavity by holding the handle or the sample collector, so that the secretion of saliva is stimulated, the collection process is accelerated, and the sample acquisition amount is increased;

2. when the sample is detected, a reagent strip or a detection device does not need to be held by hands, and the detection is finished through one extrusion action and one overturning action, so that the detection process is simplified;

3. the assembly for integrating the collection and detection processes is one assembly, so that the detection part is simplified;

4. the device has a simple structure and low cost, can be suitable for sample detection under crude conditions, is convenient for self-detection of people, and improves the detection rate;

5. and detecting a plurality of analytes at a time.

Drawings

FIG. 1 is an exploded view of a sample-testing device according to example 1;

FIG. 2 is an enlarged partial view of region "A" in FIG. 1;

FIG. 3 is an enlarged partial view of the area "B" in FIG. 1;

FIG. 4 is a schematic view showing the entire structure of a sample-detecting device according to example 1;

FIG. 5 is a cross-sectional view of FIG. 4;

FIG. 6 is a schematic view of a support in one direction in example 1;

FIG. 7 is a schematic view of the carrier in another orientation in example 1;

FIG. 8 is a schematic view showing the sample-testing device of example 1 placed on a horizontal plane by the supporting portion;

FIG. 9 is an enlarged partial view of the area "C" in FIG. 8;

FIG. 10 is a schematic view showing the entire structure of a sample-testing device according to example 2;

FIG. 11 is a schematic view showing the entire structure of a sample-testing device in one direction in example 3;

FIG. 12 is a schematic view showing the entire structure of a sample-testing device in another orientation in example 3;

FIG. 13 is a perspective view of a half section of the case of embodiment 3;

FIG. 14 is a schematic view showing the case where the carrier of the sample-testing device of example 3 is separated from the housing;

FIG. 15 is a schematic view showing the entire structure of a sample-testing device according to example 4;

FIG. 16 is a schematic view showing the entire structure of a sample-testing device in one direction in example 5;

FIG. 17 is a schematic view showing the entire structure of a sample-testing device in another orientation in example 5;

FIG. 18 is an exploded view of the specimen testing device according to example 5;

FIG. 19 is a perspective view of a sample-detecting device according to example 5;

FIG. 20 is a schematic view showing the entire structure of a sample-detecting device according to example 6.

Detailed Description

The structures referred to in the present invention or these terms of art used are further described below, and if not otherwise indicated, they are understood and explained by general terms commonly used in the art.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or a metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Sample(s)

The sample that can be detected by the detection device provided by the utility model comprises biological liquid (for example, case liquid or clinical sample). Liquid or fluid samples may be derived from solid or semi-solid samples, including fecal matter, biological tissue, and food samples. The solid or semi-solid sample may be converted to a liquid sample by any suitable method, such as mixing, triturating, macerating, incubating, dissolving, or enzymatically digesting a solid sample in a suitable solution (e.g., water, phosphate solution, or other buffered solution). "biological samples" include samples derived from animals, plants and food, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, sweat, secretions and the like from humans or animals. Preferably the biological sample is saliva. Food samples include food processing materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample or other wastewater, a soil sample, groundwater, seawater, and a waste liquid sample).

Utilize the utility model discloses suitable detecting element or test element can detect any analyte. Preferably utilizes the utility model discloses detect the drugs micromolecule in saliva, urine. Of course, any of the above forms of samples, whether initially solid or liquid, may be collected using the test device of the present invention, provided that the liquid or liquid sample is absorbed by the absorbent member. Absorbent members herein are generally made of a water-absorbent material that is initially dry and capable of absorbing a liquid or fluid sample by capillary or other properties of the absorbent member material. The absorbent material may be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, nonwoven fabric, cotton, polyester film, yarn, and the like. Of course the absorbent member need not be made of absorbent material and may be made of non-absorbent material, but rather the absorbent member has holes, threads, cavities therein, and samples, typically solid or semi-solid samples, may be collected on such structures and filled between the threads, the holes, or the pores.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flows from upstream to downstream regions. The downstream region receives liquid from the upstream region, and liquid may also flow along the upstream region to the downstream region. It is also generally divided in the direction of liquid flow, for example, on materials that use capillary forces to urge liquid flow, the liquid may flow by gravity in the opposite direction to gravity, and in this case, the upstream and downstream are also divided in the direction of liquid flow.

Gas or liquid communication

By gas or liquid communication is meant that liquid or gas can flow from one place to another, possibly guided by some physical structure during the flow. By physical structures is generally meant that the liquid flows passively or actively to another place through the surface of the physical structures or the space inside the physical structures, and passively is generally a flow caused by external force, such as a flow under capillary action. The flow here can also be a liquid or a gas, because of its own effect (gravity or pressure), or a passive flow. Communication herein does not necessarily mean that a liquid or gas is required to be present, but merely that in some cases a connection or condition between two objects, if any, may flow from one object to the other. This refers to a state in which two objects are connected, and conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a state of non-communication, non-liquid or gas communication.

Test element

The term "test element" as used herein refers to an element that can detect whether a sample or specimen contains an analyte of interest, and the detection can be based on any technical principles, such as immunology, chemistry, electricity, optics, molecular, nucleic acid, physics, etc. The test element may be a lateral flow test strip which detects a plurality of analytes. Of course, other suitable test elements may be used with the present invention.

Various test elements may be combined and used in the present invention. One form is a test strip. Test strips for the analysis of analytes, such as drugs or metabolites indicative of a physical condition, in a sample may be in various forms, such as immunoassay or chemical assay forms. The test strip may be used in a non-competitive or competitive assay format. The test strip generally comprises a bibulous material having a sample application area, a reagent area, and a test area. The sample is added to the sample application zone and flows by capillary action to the reagent zone. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for indicating the detection signal is present in the reagent zone or in a separate label zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains the analyte and no signal is generated if the analyte is not present. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The test element can be a test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength when the test strip is held in place.

The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The signal-producing substance can be on the sample addition zone, reagent zone, or detection zone, or the entire test strip, and the substance can be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal substance was added was dried.

The various regions of the test strip may be arranged as follows: the device comprises a sample adding area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

A commonly used reagent strip is a nitrocellulose membrane reagent strip, i.e., a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display the detection result; and may be a cellulose acetate film, a nylon film, or the like. Such as the reagent strips or devices containing the reagent strips described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The reagent strip disclosed in the above patent documents and similar devices with reagent strips can be applied to the test element or the detection device of the present invention to detect an analyte, such as an analyte in a sample.

The test strips used in the present invention may be so-called Lateral flow test strips (Lateral flow test strips), and the specific structure and detection principle of these test strips are well known in the art. A typical test strip comprises a sample collection area or application area, a labeling area comprising a label pad, a detection area comprising a bibulous pad, and a bibulous area comprising the necessary chemicals to detect the presence of the analyte, such as immunological or enzymatic reagents. A commonly used detection reagent strip is a nitrocellulose membrane reagent strip, that is, a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display a detection result; it may be a cellulose acetate film, a nylon film, etc., and it may also include a detection result control region downstream of the detection region, and usually, the control region and the detection region are in the form of a transverse line, which is a detection line or a control line. Such test strips are conventional, but other types of test strips that utilize capillary action for testing are also contemplated. In addition, typically, the test strip has a dry chemical reagent component, such as an immobilized antibody or other reagent, which when exposed to a liquid, flows along the test strip by capillary action, and as it flows, the dry reagent component is dissolved in the liquid, and the next zone is processed to react the dry reagent in that zone, thereby performing the necessary test. The liquid flow is mainly by capillary action. The present invention can be applied to a detecting device, or can be disposed in a detecting chamber to contact with a liquid sample, or can be used to detect whether an analyte exists or the amount of the analyte exists in the liquid sample entering the detecting chamber.

In addition to the above-described test strips or lateral flow test strips which are themselves used to contact a liquid sample to test for the presence of an analyte. In some preferred embodiments, the test elements may be disposed on a carrier, for example, in the present invention, as shown in fig. 7, the carrier 40 has a plurality of grooves 43, and the test elements are reagent strips. Generally, the reagent strip includes a sample application region, a labeling region and a detection region, the reagent strip is positioned in the groove 43, the sample application region is positioned on the open side of the groove 43 and then slightly exposes the groove 43 when the reagent strip is placed, and a part of the sample application region is reserved for absorbing the liquid sample. Typically, the sample application zone is located upstream of the labeling zone, which is located upstream of the detection zone. In some embodiments, the reagent strips in each of the wells 43 are different, and can detect a single analyte. The groove 43 is internally provided with an installation sharp corner 45, so that the reagent strip can be clamped when being installed, and the reagent strip is prevented from falling off. In some embodiments, after the reagent strip is mounted in recess 43 of carrier 40, carrier 40 is covered with a transparent film that seals the area of recess 43 of carrier 40, and the transparent film facilitates viewing of the final test results. The transparent film may also be a transparent plastic sheet, which is only transparent in the labeling area of the strip.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs of abuse (e.g., drugs of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. Abuse of these drugs can result in physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americane, white amphetamine tablets, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep-aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofballs, barbs, blue devils, yellow jacks, hypnones); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline and doxepin); dimethyldioxymethylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine, or opiates, cocaine, COC; heroin, dihydrocodeinone); anxiolytic and sedative hypnotic, anxiolytic is a kind of mainly used for relieving anxiety, stress, fear, stabilize mood, have hypnotic sedative effects at the same time, including benzodiazepine BZO (benzodiazepines), atypical BZ, fuse dinitrogen NB23C, benzodiazepine, BZ receptor ligand, ring-opening BZ, diphenylmethane derivatives, piperazine carboxylate, piperidine carboxylate, quinazolone, thiazine and thiazole derivatives, other heterocycles, imidazole type sedative/analgesic (such as dihydrocodeinone OXY, methadone MTD), propylene glycol derivative-carbamate, aliphatic compound, anthracene derivatives, etc.. The detection device of the utility model can also be used for detecting the detection which belongs to the medical purpose and is easy to take excessive medicine, such as tricyclic antidepressants (imipramine or analogues) and acetaminophen, etc. After being absorbed by human body, the medicines are metabolized into small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

For example, analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial material (e.g., proteins or carbohydrate material directed against specific bacteria, such as, for example, Escherichia coli 0157: H7, staphylococci, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Cactus), and substances associated with physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can all utilize the cooperation of side direction crossing current detection form the utility model discloses the device detects.

Detailed Description

Utilize the utility model provides a device and suitable test element, can detect any analyte. Preferably saliva is detected.

Saliva, as a non-invasive liquid, has many features, such as simple collection, safety, painlessness, easy acceptance by the subject, etc. It is increasingly being used as an index for the study and diagnosis of diseases as a biological fluid of the human body. For patients with chronic gastritis, the activity ratio of the salivary amylase of the traditional Chinese medicine composition is obviously reduced compared with that of normal people, and the traditional Chinese medicine composition is one of the widely accepted microscopic indexes capable of better reflecting gastritis. However, the index has not been generally applied clinically, which is related to the lack of standardization of saliva sample collection and low clinical detection rate.

The general method mainly adopts a method that a subject naturally reserves quantitative saliva, and a part of patients can only reserve a very small amount of saliva due to individual difference, so that the collection time needs to be prolonged, and the part of patients often generate conflicted emotion; in addition, the method of naturally flowing saliva also has the problem that the remaining saliva in the mouth is difficult to be spitted into the test tube. These factors are one of the main reasons for the decrease of the ratio of the salivary amylase activity of the patients and the low detection rate. The solution is usually to put a cotton ball, a cotton swab, etc. into the mouth of a patient to wipe or chew, to suck the saliva of the patient by the water absorption of the cotton, and then to compress the volume of the cotton ball or the cotton swab to squeeze out the saliva for testing. However, the cotton ball placed in the mouth of the patient has a smaller volume and draws less saliva; meanwhile, in the process of extruding saliva in the cotton ball, the cotton ball is difficult to be completely compressed, so that the saliva is left in the cotton ball. When the cotton swab is used, a centrifuge is usually used for squeezing saliva out of the cotton swab, but the centrifuge is expensive and not convenient to use. To the sample that awaits measuring the sample testing need hand the test rod with the application of sample district that detects test paper dip in the sample to wait for the sample to spread to the detection zone, waste time when the sample that awaits measuring is more. Meanwhile, in the prior art, a test tube and test paper need to be prepared during detection, and a user needs to unseal a plurality of different parts in one detection, which is very troublesome.

The present invention thus improves upon the prior art from the three aspects of increasing the amount of saliva obtained, simplifying the testing process, and integrating the two processes of collection, testing into one assembly.

Example 1, see figures 1-9.

Referring to fig. 1, a sample testing device includes a handle 10 with an absorbent member 11, the absorbent member 11 having a volume much larger than that of a conventional cotton ball, so that it can absorb a larger amount of saliva during the process of collecting saliva. In addition, when the handle 10 with the absorption element 11 collects saliva, the patient holds the absorption element 11 in the mouth, and the absorption element 11 can rub the oral cavity to stimulate the secretion of saliva and accelerate the collection process, which is not realized by the common cotton ball.

The sample detection device further comprises a shell 12, a sample cavity 36 is arranged in the shell 12, the sample cavity 36 is communicated with the outside, an extrusion unit 13 is arranged on the shell 12, a channel 37 is arranged on the extrusion unit 13, the communication position of the channel 37 and the outside is an opening of the extrusion unit 13, the opening direction of the extrusion unit 13 is the direction of the channel 37, a through hole 14 is arranged at the junction position of the extrusion unit 13 and the shell 12, the through hole 14 enables the inside (the channel 37) of the extrusion unit 13 to be communicated with the inside (the sample cavity 36) of the shell 12, and a sample can be extruded into the sample cavity 36 in the shell 12 through the through hole 14 by extruding the bottoms of the absorption element 11 on the handle 10 and the channel 37 of the extrusion. Specifically, referring to fig. 1 and 4, the housing 12 is plate-shaped, the plane of the housing 12 is plate-shaped, the absorbing element 11 is cylindrical, the side of the handle 10 connected to the absorbing element 11 is disc-shaped, the squeezing unit 13 is cylindrical barrel-shaped, the direction of the channel 37 inside the squeezing unit 13 is perpendicular to the plate-shaped plane of the housing 12, and the radius of the disc position on the handle 10 is equal to the inner diameter (inner diameter of the channel 37) of the squeezing unit 13, so that when the handle 10 is squeezed by the channel 37, as much saliva in the absorbing element 11 as possible enters the sample cavity 36 of the housing 12, and does not overflow from the gap between the handle 10 and the squeezing unit 13. In the present embodiment, the through-hole 14 is circular. The through-hole 14 is not provided too large, which may cause the absorption element 11 to be partially embedded in the through-hole 14; the through-hole 14 should not be too small, which would make it inconvenient for the absorbent member 11 to squeeze the released saliva into the sample chamber 36. Therefore, a plurality of through holes 14 with proper size are preferably arranged at the bottom of the cylindrical barrel of the squeezing unit 13, the diameter of the through holes 14 is 1/4-1/2 of the inner diameter of the channel 37, and the number of the through holes is 5-15. In some other embodiments, the through-holes 14 are square, triangular, etc. in geometry. In some other embodiments, the through holes 14 are replaced by a mesh grid, or a bar grid, and the through holes 14 only have to support the absorbent member 11 when the absorbent member 11 is compressed and have a communication function, so that the sample can enter the sample chamber 36.

The housing 12 and the carrier 40 are detachable. Specifically, referring to fig. 1, the carrier 40 can be inserted into the housing 12, and the housing 12 and the carrier 40 form a drawer structure, which is mainly embodied as: both carrier 40 and housing 12 are flat, and carrier 40 is capable of a drawer-type "pull" motion within housing 12. When carrier 40 is fully inserted into housing 12, carrier 40 is mounted in housing 12, as follows. A hollow area 16 is provided in housing 12, and hollow area 16 facilitates an operator to view all of the reagent strips in carrier 40. In this embodiment, the hollow area 16 is square and extends out of the housing 12, such that the side of the housing 12 having the hollow area 16 is "concave". Clamping grooves 15 are symmetrically formed in the shell 12 at two sides of the hollow area 16, correspondingly, first protrusions 17 are arranged on the carrier 40, and the first protrusions 17 can be clamped into the clamping grooves 15, so that the carrier 40 is fixed in the shell 12 (fixed in the sample cavity 36). Preferably, referring to fig. 2-3, two sharp corners 18 are disposed at the position of the slot 15, the two sharp corners 18 form a first opening with a gradually decreasing opening, the angle range of the first opening is 20 ° to 160 °, and preferably 40 ° to 90 °, so that the first protrusion 17 can be more conveniently clamped into the slot 15, and the clamped first protrusion 17 is not easy to fall off from the slot 15. In some other embodiments, only one sharp corner 18 may be provided, and the sharp corner 18 and the slot 15 form a first opening with a gradually decreasing opening. As a further preferred option, the housing 12 is further provided with a recessed ledge 19 at a position near the card slot 15, the recessed ledge 19 being positioned slightly below the edge of the housing 12, and correspondingly, the carrier 40 is provided with a protruding ledge 20 at a position near the first protrusion 17, when the housing 12 and the carrier 40 are assembled together, the first protrusion 17 is snapped into the card slot 15, the protruding ledge 20 rests on the recessed ledge 19, and the carrier 40 is flush with the edge of the housing 12.

Preferably, referring to fig. 1, a second protrusion 41 is further disposed in the housing 12, a third protrusion 42 is further disposed on the carrier 40, the second protrusion 41 and the third protrusion 42 are protruding arc-shaped blocks, when the housing 12 and the carrier 40 are assembled together, the second protrusion 41 and the third protrusion 42 are also clamped together, generally, the third protrusion 42 is located at a lower side position of the second protrusion 41, and the slot 15, the first protrusion 17, the second protrusion 41 and the third protrusion 42 form a double fixation, so that the carrier 40 is not easy to fall off.

The housing 12 is provided with a support portion 21, and the support portion 21 enables the housing 12 to stand upright after being turned upside down. In some forms, the support location 21 is one or more plates that connect the housing 12 to the compression unit 13.

Referring to fig. 4-5, in the present embodiment, since the channel 37 inside the compressing unit 13 is perpendicular to the plate-shaped plane of the housing 12, the compressing direction of the absorbing element 11 and the compressing unit 13 during compressing is perpendicular to the reagent strip-mounted surface of the carrier 40, and during compressing of the absorbing element 11, the reagent strip-mounted surface of the housing 12 is generally placed on a horizontal plane for compressing, and the housing 12 is in a state of being upright, the channel 37 inside the compressing unit 13 is perpendicular to the horizontal plane, and the plate-shaped plane of the housing 12 is parallel to the horizontal plane. After the pressing is completed, the housing 12 is turned over, and referring to fig. 8 and 9, the housing 12 is erected on a horizontal plane through the supporting portion 21, and the housing 12 is turned over, the direction of the passage 37 in the pressing unit 13 is parallel to the horizontal plane, and the plate-shaped plane of the housing 12 is perpendicular to the horizontal plane. Meanwhile, the sample contacts with the sample application area of the reagent strip in the shell 12 under the action of gravity, the sample application area of the reagent strip flows to the marking area and the detection area under the action of capillary phenomenon, the detection of the sample is completed, and meanwhile, after the shell 12 is turned over, one surface of the shell 12, on which the reagent strip is arranged, is exposed, and the reading result can be directly observed. The sample is detected without holding a reagent strip or a detection device by hands, and the detection is finished through one extrusion action and one overturning action, so that the detection process is simplified. Preferably, the sample application area of the strip extends to the bottom of the sample chamber 36 slightly beyond the recess 43, which facilitates sample contact with the sample application area of the strip.

Preferably, referring to fig. 6 and 7, the liquid storage tank 22 is arranged on the surface of the carrier 40 opposite to the groove 43, when the carrier 40 is mounted in the housing 12, the liquid storage tank 22 corresponds to the through hole 14 and can wrap all the through holes 14, the liquid storage tank 22 is tightly attached to the inner wall of the sample cavity 36 (the inner wall of the housing 12), a notch 23 is arranged on one side of the liquid storage tank 22 close to the opening of the groove 43, and the position of the notch 23 is slightly lower than that of the liquid storage tank 22. The reservoir 22 is arranged in the sense that: when the face of the housing 12, on which the reagent strip is mounted, is placed on a horizontal plane (the housing 12 is in a positive state), the reagent strip is in a horizontal placement state at this time, and the sample application region, the labeling region and the detection region of the reagent strip are at the same horizontal height, so that the sample may contact with the sample application region, the labeling region and the detection region of the reagent strip, and the test structure is inaccurate. At the same time, saliva may leak from the hollow area 16 to the outside due to the presence of the hollow area 16. After the reservoir 22 is present, the saliva produced by the squeezing of the absorbent element 11 can be stored in the reservoir 22; when the housing 12 is turned over and is erected on the horizontal surface through the supporting portion 21 (the housing 12 is in a turned-over state), saliva in the reservoir 22 can enter the sample cavity 36 from the notch 23 under the action of gravity and only can be in contact with the sample application area of the reagent strip, and the hollow area 16 is higher than the saliva in the sample cavity 36, so that the leakage of the saliva is avoided. Furthermore, due to the presence of the reservoir 22, when the housing 12 is in the upright position, the sample is stored in the reservoir 22 and does not contact the reagent strip; when the housing 12 is in the inverted state, the sample flows from within the reservoir 22 and into contact with the reagent strip. The significance of the reservoir 22 abutting the inner wall of the sample chamber 36 is: the sample in the reservoir 22 can only flow out through the notch 23 of the sample chamber 36.

Preferably, a piece of transparent plastic or transparent glass is installed in the hollow area 16, so that the hollow area 16 does not leak liquid without affecting the observation result.

Preferably, referring to fig. 5 and 6, the groove wall of the reservoir 22 on the side provided with the notch 23 is inclined so that the saliva in the reservoir 22 can completely flow into the sample chamber 36 to be in full contact with the reagent strip when the housing 12 is erected on the horizontal surface through the support portion 21 (the housing 12 is in the inverted state).

Preferably, referring to fig. 4 and 6, a first inclined surface 24 is provided on a side of the housing 12 close to the pressing unit 13, a second inclined surface 25 is provided on the carrier 40, the first inclined surface 24 and the second inclined surface 25 are inclined in the same direction, and the first inclined surface 24 and the second inclined surface 25 are mainly provided to distinguish the installation direction of the carrier 40 and prevent the carrier 40 from being reversely installed. The second inclined surface 25 is inclined in the direction opposite to the groove wall of the reservoir 22 on the side of the notch 23. The first inclined surface 24 also raises the level of saliva in the sample chamber 36 to facilitate contact of the saliva with the sample application area of the test strip.

The following provides a matched detection method by combining the sample detection device:

1. loading a reagent strip on the carrier 40;

2. aligning the first inclined surface 24 with the second inclined surface 25, installing the carrier 40 in the housing 12, and placing the side of the housing 12, on which the reagent strip is installed, on a horizontal plane (the housing 12 is in a positive state);

3. collecting a sample using the absorbent element 11 on the handle 10;

4. inserting the handle 10 into the channel 37 in the squeezing unit 13 and squeezing the absorbent member 11, the sample is squeezed out and enters the reservoir 22 through the through hole 14; (FIG. 5)

5. Turning over the housing 12 to make the housing 12 stand on the horizontal plane through the supporting portion 21 (the housing 12 is in a turned-over state), and allowing the sample to enter the sample cavity 36 from the liquid storage tank 22 through the notch 23 under the action of gravity and to contact with the sample application area of the reagent strip; (FIG. 9)

6. Waiting a period of time, the reagent strip read on carrier 40 is viewed through hollow area 16.

Preferably, when a sufficient amount of sample has been collected by the absorbent member 11, the absorbent member 11 is inserted into the channel 37 in the squeezing unit 13 and squeezed by pushing the handle 10 to the bottom of the channel 37, and the absorbent member 11 is completely compressed a plurality of times to transfer most of the sample from the absorbent member 11 to the reservoir 22.

Example 2, see figure 10.

In this embodiment, the hollow area 16 is square but does not extend beyond the housing 12, the hollow area 16 exposes the labeled area of the strip, and the side of the housing 12 where the hollow area 16 is located is "mouth" shaped.

Other embodiments of this example are the same as example 1.

Example 3, see figures 11-14.

In this embodiment, the channel 37 inside the pressing unit 13 is parallel to the plate-shaped plane of the housing 12, and the pressing direction of the absorbent member 11 and the pressing unit 13 during pressing is parallel to the reagent strip-mounted surface of the carrier 40, so that the advantage of the design is that the housing 12 does not need to be turned over during the detection process, thereby further simplifying the detection process, but also providing a technical disadvantage that the stability of the device during placement is inferior to that provided by embodiment 1 due to the reduced contact area between the device and the horizontal surface during the detection process.

Preferably, referring to fig. 13, since the pressing direction of the absorbing element 11 and the pressing unit 13 during pressing is parallel to the reagent strip mounting surface of the carrier 40, the absorbing element 11 is pressed against the bottom of the channel 37 in the pressing unit 13 instead of the through hole 14 during pressing, so that it is no longer necessary to consider whether the absorbing element 11 is jammed in the through hole 14, and therefore the through hole 14 only needs to be larger. Further preferably, the lowest position in the sample chamber 36 is lower than the bottom position of the channel 37, the through hole 14 communicates the bottom of the channel 37 with the sample chamber 36, and the lowest position in the sample chamber 36 is lower than the lowest position in the channel 37, so that the sample can flow into the sample chamber 36 as much as possible.

Preferably, referring to fig. 14, since the device in this embodiment does not need to be turned over, in the sample detection device provided in this embodiment, the supporting portion 21 is not provided, and in order to ensure the stability of the device when it is placed, it is only necessary to make the bottom position of the pressing unit 13 flush with the bottom position of the housing 12. And also does not require a reservoir 22 designed for temporary storage of the sample.

Preferably, referring to FIG. 12, the housing 12 is provided with a viewing window 26 at a position below the hollow area 16, the viewing window 26 is used for viewing the sample application area of the reagent strip for determining whether the sample is sufficient, since the viewing window 26 only needs to view the sample liquid level in the detection device and does not need to perform reading, and the hollow area 16 needs to read the results of all the reagent strips, the viewing window 26 is much smaller than the hollow area 16. Further, the viewing window 26 can also be fitted with transparent plastic or glass.

Since the structure of the device is modified with respect to embodiment 1, a matched detection method is provided below with reference to a sample detection device in this embodiment:

1. loading a reagent strip on the carrier 40;

2. aligning the first inclined surface 24 with the second inclined surface 25, mounting the carrier 40 in the housing 12, and placing the bottom side of the pressing unit 13 on a horizontal plane; (FIG. 14)

3. Collecting a sample using the absorbent element 11 on the handle 10;

4. inserting the handle 10 into the channel 37 of the squeezing unit 13 and squeezing the absorbent member 11, the sample is squeezed out and enters the sample chamber 36 through the through hole 14;

5. observing through the observation window 26 whether the sample is in contact with the sample application area of the reagent strip, and if not, repeating operation 3; if so, performing step 6;

6. waiting a period of time, the reagent strip read on carrier 40 is viewed through hollow area 16.

Other embodiments of this example are the same as example 1.

Example 4, see figure 15.

In the present embodiment, the hollow area 16 is square but does not extend out of the housing 12, the hollow area 16 exposes the label area of the reagent strip, the housing 12 is provided with an observation window 26 at a position below the hollow area 16, and the housing 12 is provided with a "sun" shape on the side where the hollow area 16 is provided.

Other embodiments of this example are the same as example 3.

Example 5, see figures 16-19.

In this embodiment, based on a further improvement of embodiment 4, in embodiment 4, an operator presses the handle 10 to press the absorption element 11 and the pressing unit 13 to release the sample, when the operator stops pressing the handle 10, the absorption element 11 rebounds and absorbs part of the sample, if the number of samples acquired by the absorption element 11 during acquisition only just meets the amount required for detection, then along with the rebounding of the absorption element 11, a part of the sample is absorbed, resulting in insufficient sample amount and further requiring secondary sampling, which makes the detection flow cumbersome. Furthermore, in all of the sample testing devices provided in examples 1-4, there is no permanent connection between the handle 10 and the device, i.e., the handle 10 is easily detached from the device during transportation of the device.

In order to solve the two technical problems, the technical scheme is as follows: the top of the pressing unit 13 is flush with the top of the housing 12, an "L" -shaped groove 33 is formed at the opening position of the pressing unit 13, and the upper end of the "L" -shaped groove 33 penetrates through the pressing unit 13. The handle 10 is replaced with a sample collector 27. the sample collector 27 comprises a cover head 28, a connecting rod 29, and a mounting end 30. The connecting rod 29 connects the cap 28 and the mounting end 30, the cap 28 being used to connect the sample collector 27 to the pressing unit 13, and the mounting end 30 being used to connect the absorbing element 11. The cover head 28 comprises an upper cover 31 and a lower cover 32, the lower cover 32 can be embedded into an opening of the extrusion unit 13, a clamping point 34 is arranged on the lower cover 32, the clamping point 34 can move along an L-shaped groove 33, lines are arranged on the upper cover 31, and the sample sampler 27 can be rotated by an operator conveniently. When the device is used, the clamping point 34 on the cover head 28 is pressed down to the lowest position along the L-shaped groove 33, the absorption element 11 connected with the sample collector 27 is completely extruded at the moment, then the cover head 28 is rotated, so that the clamping point 34 continuously moves along the L-shaped groove 33, and as the absorption element 11 has the rebound tendency, the clamping point 34 is clamped in the L-shaped groove 33 and cannot move on the premise of no external force, namely, the sample collector 27 is fixed relative to the device and cannot fall off in the transportation process of the device; meanwhile, the absorption element 11 is always in a completely compressed state, so that a sample cannot be absorbed, and the sampling frequency is reduced. The technical scheme can integrate the components for collecting and detecting the two processes into one component.

Preferably, the opening of the squeezing unit 13 is provided with two "L" shaped slots 33 in a central symmetry manner, correspondingly, the lower cover 32 is provided with two clamping points 34 in a central symmetry manner, and the two "L" shaped slots 33 and the two clamping points 34 are designed in a matching manner, so that the assembly of the sample collector 27 and the device is facilitated. In addition, the cover head 28 is hollow inside, which is to reduce the weight of the cover head 28 part of the device and avoid the situation of 'heavy head and light foot' which leads to the unstable placement of the device on the horizontal plane.

Since the structure of the device is modified with respect to embodiment 4, a matched detection method is provided below with reference to a sample detection device in this embodiment:

1. loading a reagent strip on the carrier 40;

2. aligning the first inclined surface 24 with the second inclined surface 25, mounting the carrier 40 in the housing 12, and placing the bottom side of the pressing unit 13 on a horizontal plane;

3. collecting a sample using the absorbent member 11 on the sample collector 27;

4. the sample collector 27 is inserted into the channel 37 of the pressing unit 13, the clamping point 34 on the cover head 28 is pressed to the lowest position along the L-shaped groove 33, the absorption element 11 is pressed, and the sample is extruded and enters the sample cavity 36 through the through hole 14;

5. observing through the observation window 26 whether the sample is in contact with the sample application area of the reagent strip, and if not, repeating operation 3; if so, performing step 6;

6. the cover head 28 on the sample collector 27 is rotated so that the stuck point 34 continues to move along the "L" shaped slot 33.

7. Waiting a period of time, the reagent strip read on carrier 40 is viewed through hollow area 16.

Other embodiments of this example are the same as example 4.

Example 6, see figure 20.

In this embodiment, the hollow area 16 is square but extends out of the housing 12, the hollow area 16 exposing the labeled area of the reagent strip.

Other embodiments of this example are the same as example 5.

The above description is only the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through creative work should be covered within the protection scope of the present invention, and therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

The utility model shown and described herein may be implemented in the absence of any element, limitation, or limitations specifically disclosed herein. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, and it is recognized that various modifications are possible within the scope of the invention. It should therefore be understood that although the present invention has been specifically disclosed by various embodiments and optional features, modification and variation of the concepts herein described may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the appended claims.

The contents of the articles, patents, patent applications, and all other documents and electronically available information described or cited herein are hereby incorporated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such articles, patents, patent applications, or other documents.

Claims (10)

1. A sample detection device is characterized by comprising a shell and a carrier, wherein the carrier is provided with a test element, the shell can contain a sample, the carrier can be inserted into the shell, the shell and the carrier form a drawer type structure, when the carrier is completely inserted into the shell, the test element is contacted with the sample, and the test element detects an analyzed substance of the sample.

2. The apparatus according to claim 1, wherein the housing has a slot, and the carrier has a first protrusion, wherein the first protrusion is configured to be inserted into the slot when the carrier is fully inserted into the housing.

3. The apparatus according to claim 2, wherein the notch has a sharp corner, and the sharp corner of the notch defines a first opening with a gradually decreasing opening.

4. The apparatus according to claim 3, wherein the tip has two corners, and the first opening is formed between the two corners.

5. The sample testing device of claim 4, wherein the angle of the first opening is in the range of 20 ° to 160 °.

6. The apparatus according to claim 1, wherein the carrier has a raised platform and the housing has a recessed platform, the raised platform resting on the recessed platform when the carrier is fully inserted into the housing.

7. The apparatus according to claim 1, wherein the housing has a second protrusion, the carrier has a third protrusion, and the second protrusion and the third protrusion are engaged when the carrier is fully inserted into the housing.

8. The apparatus according to claim 7, wherein the second and third protrusions are arc-shaped blocks.

9. The apparatus according to claim 1, wherein the housing has a hollow area, and the hollow area exposes the test element on the carrier when the carrier is fully inserted into the housing.

10. The apparatus according to claim 2 or 9, wherein there are two slots, and the two slots are symmetrically disposed on two sides of the hollow region.

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