CN212931986U - Detection box - Google Patents

Abstract

The utility model provides a detection box, which comprises a fluid sample collection cavity, a liquid sample collection cavity and a liquid sample detection cavity, wherein the collection cavity comprises an opening, and a test element is arranged in the collection cavity and is used for testing whether an analyte exists in the fluid sample or not; the detection box also comprises a cover body used for covering the opening of the collection cavity, wherein the cover body comprises a buckle structure used for clamping the opening of the collection cavity, and when the cover body covers the opening of the collection cavity, the buckle structure is clamped with the outer wall of the opening of the collection cavity, so that the cover body is fixed on the collection cavity. The utility model adopts the form that the cover body and the collection cavity are covered, the cover body and the bottle body are easily covered and difficult to separate through the arrangement of the buckle structure, and compared with the traditional screw thread rotating mode of the cover body and the collection cavity, the utility model has the advantages of convenience and fast detection efficiency; the sampling hole is arranged on the side surface of the collection cavity and is close to the corner part, so that a test strip or a test element on the carrier can be avoided, and the sampling hole is prevented from being blocked by a sample application area of the test strip or the test element during secondary sampling.

Description

Detection box

Technical Field

The utility model relates to a device for collecting and detecting analyzed substances in liquid samples, such as urine and saliva collecting and detecting box, belonging to the technical field of in vitro rapid detection, in particular to the field of rapid diagnosis.

Background

The following background description is merely an introduction to the general knowledge and is not intended to limit the invention in any way.

Currently, cartridges for detecting whether a sample contains an analyte are widely used in hospitals or homes, and these cartridges for rapid diagnosis include one or more test strips, such as an early pregnancy test, a drug abuse test, and the like. The rapid diagnosis test kit is convenient, and the test result can be obtained on the test reagent strip within one minute or at most ten minutes.

Drug detection is widely applied and is commonly used in drug-resistant departments, public security bureaus, drug rehabilitation centers, physical examination centers, national soldier physical examination places and other institutions. The drug detection is various in types and frequent in times. Some require the collection of a sample and then require a specialized testing facility or testing laboratory to perform the test. Some people need to complete detection on site in time, for example, people who drive after taking poison (called poison driving for short) need to perform detection on site, and then obtain the detection result in time. And (4) detecting drugs, wherein the samples can be urine, sweat, hair and saliva samples.

For testing saliva samples, they are increasingly accepted and welcomed by testing agencies or testing personnel based on convenient collection. Various sample collection and testing devices for clinical or home use have been seen and described in some literature. For example, U.S. Pat. No. 5,376,337 discloses a saliva sample collector in which a piece of filter paper is used to collect saliva from the mouth of a subject and transfer the saliva onto an indicator reagent. US 5,576,009 and US 5,352,410 each disclose a syringe-type fluid sample collector.

In US 7,927,562 a drug testing device is also described, the cap of which cooperates with a collection device in the form of a screw thread for collecting a test strip. Although this screw thread type seal serves the purpose of sealing the collection chamber, it is still inconvenient to operate, especially when there are many samples to be tested, and it is inconvenient and inefficient to rotate. For another example, in US 9,462,998, another drug detecting device is described, in which a raised tab is provided on the cover, which tab, when the cover is inserted into the cavity, contacts the inner wall of the collection chamber, thereby allowing the cover to be retained on the collection chamber, thereby limiting its position. The thin sheet structure arranged by the device is not easy to realize in the design and production of actual products, and the production of a mould of plastic parts is difficult.

There is a need for an improved prior art test cartridge that provides a simpler means of sample collection and testing.

Disclosure of Invention

An object of the utility model is to provide a detect box to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the present invention provides a test kit, which comprises a fluid sample collection chamber having an opening, a test element disposed in the collection chamber for testing whether an analyte exists in the fluid sample; the detection box also comprises a cover body for covering the opening of the collection cavity;

wherein, the lid is including being used for the joint to collect the open-ended buckle structure of chamber, and when the lid closed and collects the chamber open-ended, the open-ended outer wall in chamber is collected to buckle structure joint to let the lid fix on collecting the chamber.

Further, collect chamber outer wall including protruding structure, when the lid closes the collection chamber opening, buckle structure joint protruding structure, as preferred technical scheme, the outer wall in collection chamber has the protruding structure of square frame shape.

Further, be equipped with two buckle structures in the lid at least, buckle structure is right angle or straight line, and as preferred technical scheme, the lid is whole to be squarely, all is equipped with buckle structure on the four corners of lid, and buckle structure is the right angle, and protruding structure cooperates with four buckle structure to when letting the lid close the collection chamber opening, the lid is more difficult to break away from and collects the chamber.

Furthermore, the cover body is provided with a holding part, the holding part is convenient for an operator to exert force on the cover body, the holding part and the cover body are integrally formed, the processing is convenient, the lower part of the holding part is hollow, and the overall weight of the detection box can be reduced.

Furthermore, the bottom of the collection cavity protrudes upwards, so that the liquid sample in the collection cavity can be dispersed around and fully contacted with the test element, and the sampling quantity of the liquid sample can be reduced on the premise of not influencing the detection result.

Furthermore, the buckle structure comprises a lower buckle surface and an upper buckle surface, the angle of the angle formed by the lower buckle surface and the horizontal plane is larger than the angle of the angle formed by the upper buckle surface and the horizontal plane, so that the slope of the lower buckle surface is larger than that of the upper buckle surface, when the cover body and the collection cavity need to be covered, as the slope of the lower buckle surface is larger, the lower buckle surface is contacted with the bulge structure, the covering process of the cover body and the collection cavity is relatively easy, and a process of slow elastic deformation is formed between the lower buckle surface and the bulge structure, so the required force is smaller. The feeling when the operator is buckled is embodied as follows: can be buckled by lightly pushing. When lid and collection chamber need be separated, because the slope of going up the spiral-lock face is less, the process that goes up spiral-lock face and protruding structure contact and cause lid and collection chamber separation is difficult relatively, is a process that takes place elastic deformation fast each other, and the sensation when embodying operating personnel to separate is: a large force is required to separate.

Further, the lid is squarely, and spacing card strip is located on the lid inner wall and the bight position of lid, is equipped with spacing card strip in the lid, and spacing card strip includes first spacing part and second spacing part, and first spacing part is spacing to protruding structure, makes the lid remain stable on the body, and second spacing structure is spacing to collecting the chamber opening, makes the body upper end embedding unable rocking in the lid.

Further, the lower buckling surface is a smooth surface, and the convex structure on the collecting cavity comprises an upper convex surface and a lower convex surface, wherein the upper convex surface is in contact with the lower buckling surface to guide the lower convex surface to be in contact with the upper buckling surface.

Further, the detection box still includes the carrier, a plurality of draw-in grooves that are used for setting up test element have on the carrier, the carrier is arranged in collecting the chamber, the cavity has in the carrier, the carrier has the bottom simultaneously, the carrier bottom is equipped with the through-hole, the carrier, it is square to collect the chamber, it is equipped with the thief hole to collect the chamber side and be close to the bight position, test strip or test element on the carrier can be avoided, test strip or test element's sample is applyed the region and is stopped up the thief hole when preventing secondary sampling, the sample receives the pollution when can avoiding taking a sample from the direct sample of thief hole.

Further, a sample collector is disposed on the cover for insertion into the cavity in the carrier and contact with the bottom of the carrier.

Furthermore, an annular groove is formed in the sample collector, a sealing ring can be arranged in the annular groove, and the sealing ring can be sealed with the collecting cavity.

Furthermore, the bottom of the carrier is provided with a second boss which is in a square frame shape, the bottom of the collecting cavity is provided with a supporting piece, and the supporting piece supports four corners of the second boss.

To sum up, the utility model has the advantages that: the utility model provides a form that detection box adopts lid and collection chamber lid to close, and it is easy to make lid, body lid close through the setting of buckle structure, and it is difficult to separate, and lid and the lid of collection chamber close the mode and traditional lid and the rotatory mode of collection chamber screw thread all have easy and simple to handle, extrude the absorption element, improve detection efficiency's advantage, but relatively speaking, in the detection process of repetition many times, the mode of screw thread rotation is more loaded down with trivial details than the technical scheme that the utility model provides, difficult to operate; the outer surface of the carrier is provided with a plurality of grooves which can be used for mounting different test elements to realize the function of single multiple detection; the bottom of the bottle body is upwards convex, so that the liquid sample in the collection cavity can be dispersed to the periphery and fully contacted with the test element, and the sampling quantity of the liquid sample can be reduced on the premise of not influencing the detection result; the first boss and the second boss on the carrier are matched with the limit buckle and the support piece in the collection cavity, so that the carrier is loaded in the collection cavity to be kept stable and not easy to fall off; the sampling hole is arranged on the side surface of the bottle body (collection cavity) close to the corner part, so that a test strip or a test element on the carrier can be avoided, the sampling hole is prevented from being blocked by a sample application area of the test strip or the test element during secondary sampling, and meanwhile, the sample can be prevented from being polluted during sampling by directly sampling from the sampling hole; the sealing ring on the connecting end of the sample collector is attached to the inner wall of the collection cavity to form a sealing area, so that the liquid sample can be prevented from leaking out of the collection cavity or the carrier when the detection box is violently shaken and turned upside down.

Drawings

FIG. 1 is a schematic structural view of a carrier;

FIG. 2 is a schematic structural view of the bottle body;

FIG. 3 is an exploded view of the cartridge;

FIG. 4 is a schematic view of the bottom structure of the cartridge;

FIG. 5 is a top view of the body;

FIG. 6 is an exploded view of a sample collector;

FIG. 7 is a view showing the connection of the cap, carrier and body when they are cut open;

FIG. 8 is a schematic view of the structure of the cover;

FIG. 9 is a schematic view in half section of the cover;

FIG. 10 is a schematic view showing the overall construction of a cartridge;

FIG. 11 is an enlarged partial view of the areas "A" and "B" in FIG. 7;

fig. 12 is a partially enlarged view of the areas "C" and "D" in fig. 7.

Detailed Description

The structures referred to in the present invention or these terms of art used are further described below, and if not otherwise indicated, they are understood and explained by general terms commonly used in the art.

Detection of

Detection refers to assaying or testing for the presence of a substance or material, such as, but not limited to, a chemical, organic compound, inorganic compound, metabolic product, drug or drug metabolite, organic tissue or a metabolite of organic tissue, nucleic acid, protein, or polymer. In addition, detection indicates the amount of the test substance or material. Further, the assay means immunodetection, chemical detection, enzyme detection, and the like.

Sample(s)

The test cartridge or collected sample of the present invention comprises a biological fluid (e.g., a case fluid or a clinical sample). Liquid or liquid samples, or fluid samples, may be derived from solid or semi-solid samples, including fecal, biological tissue and food samples. The solid or semi-solid sample may be converted to a liquid sample by any suitable method, such as mixing, triturating, macerating, incubating, dissolving, or enzymatically digesting a solid sample in a suitable solution (e.g., water, phosphate solution, or other buffered solution). "biological samples" include samples derived from animals, plants and food, including, for example, urine, saliva, blood and components thereof, spinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, cultures, cell cultures and media of tissues and organs derived from humans or animals. Preferably, the biological sample is urine and preferably, the biological sample is saliva. Food samples include food processing materials, end products, meat, cheese, wine, milk and drinking water. Plant samples include those derived from any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (e.g., a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a waste liquid sample). Environmental samples may also include sewage or other wastewater.

Utilize the utility model discloses suitable detecting element or test element can detect any analyte. Preferably utilizes the utility model discloses detect the drugs micromolecule in saliva, urine. Of course, any of the above types of samples, whether initially solid or liquid, can be collected using the cartridge of the present invention, provided that the liquid or liquid sample is absorbed by the absorbent member. Absorbent members herein are generally made of a water-absorbent material that is initially dry and capable of absorbing a liquid or fluid sample by capillary or other properties of the absorbent member material. The absorbent material may be any material capable of absorbing liquid, such as sponge, filter paper, polyester fiber, gel, nonwoven fabric, cotton, polyester film, yarn, and the like. Of course the absorbent member need not be made of absorbent material and may be made of non-absorbent material, but rather the absorbent member has holes, threads, cavities therein, and samples, typically solid or semi-solid samples, may be collected on such structures and filled between the threads, the holes, or the pores.

Downstream and upstream

Downstream or upstream is divided with respect to the direction of liquid flow, typically liquid flows from upstream to downstream regions. The downstream region receives liquid from the upstream region, and liquid may also flow along the upstream region to the downstream region. It is also generally divided in the direction of liquid flow, for example, on materials that use capillary forces to urge liquid flow, the liquid may flow by gravity in the opposite direction to gravity, and in this case, the upstream and downstream are also divided in the direction of liquid flow.

Gas or liquid communication

By gas or liquid communication is meant that liquid or gas can flow from one place to another, possibly guided by some physical structure during the flow. By physical structures is generally meant that the liquid flows passively or actively to another place through the surface of the physical structures or the space inside the physical structures, and passively is generally a flow caused by external force, such as a flow under capillary action. The flow here can also be a liquid or a gas, because of its own effect (gravity or pressure), or a passive flow. Communication herein does not necessarily mean that a liquid or gas is required to be present, but merely that in some cases a connection or condition between two objects, if any, may flow from one object to the other. This refers to a state in which two objects are connected, and conversely, if there is no liquid communication or gas communication between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on the other object, and such a state is a state of non-communication, non-liquid or gas communication.

Test element

The term "test element" as used herein refers to an element that can detect whether a sample or specimen contains an analyte of interest, and the detection can be based on any technical principles, such as immunology, chemistry, electricity, optics, molecular, nucleic acid, physics, etc. The test element may be a lateral flow test strip which detects a plurality of analytes. Of course, other suitable test elements may be used with the present invention.

Various test elements may be combined and used in the present invention. One form is a test strip. Test strips for the analysis of analytes, such as drugs or metabolites indicative of a physical condition, in a sample may be in various forms, such as immunoassay or chemical assay forms. The test strip may be used in a non-competitive or competitive assay format. The test strip generally comprises a bibulous material having a sample application area, a reagent area, and a test area. The sample is added to the sample application zone and flows by capillary action to the reagent zone. In the reagent zone, the sample binds to the reagent if the analyte is present. The sample then continues to flow to the detection zone. Other reagents, such as molecules that specifically bind to the analyte, are immobilized at the detection zone. These reagents react with the analyte (if present) in the sample and bind the analyte to the zone, or to one of the reagents of the reagent zone. The label for indicating the detection signal is present in the reagent zone or in a separate label zone.

A typical non-competitive assay format is one in which a signal is generated if the sample contains the analyte and no signal is generated if the analyte is not present. In a competition method, a signal is generated if the analyte is not present in the sample and no signal is generated if the analyte is present.

The test element can be a test paper, and can be made of water-absorbing or non-water-absorbing materials. The test strip may include a variety of materials for liquid sample delivery. One of the test strips may be coated with another material, such as a nitrocellulose membrane coated with filter paper. One region of the test strip may be selected from one or more materials and another region may be selected from a different one or more materials. The test strip may be adhered to some support or hard surface for improved strength when the test strip is held in place.

The analyte is detected by a signal producing system, such as one or more enzymes that specifically react with the analyte, and one or more compositions of the signal producing system are immobilized on the analyte detection zone of the test strip by a method such as that described above for the immobilization of a specific binding substance on the test strip. The signal-producing substance can be on the sample addition zone, reagent zone, or detection zone, or the entire test strip, and the substance can be impregnated on one or more materials of the test strip. A solution containing the signal is applied to the surface of the strip or one or more materials of the strip are immersed in the solution containing the signal. The strip to which the solution containing the signal substance was added was dried.

The various regions of the test strip may be arranged as follows: the device comprises a sample adding area, a reagent area, a detection area, a control area, a sample adulteration area and a liquid sample absorption area. The control zone is located behind the detection zone. All zones may be arranged on a strip of test paper using only one material. It is also possible to use different materials for the different zones. The zones may be in direct contact with the liquid sample, or different zones may be arranged according to the direction of flow of the liquid sample, with the ends of each zone being contiguous with and overlapping the ends of the other zone. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip may take other forms.

A commonly used reagent strip is a nitrocellulose membrane reagent strip, i.e., a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display the detection result; and may be a cellulose acetate film, a nylon film, or the like. Such as the reagent strips or devices containing the reagent strips described in some of the following patents: US 4857453; US 5073484; US 5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US 5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US 6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US 6306642; US 6352862; US 6372515; US 6379620; and US 6403383. The test strips disclosed in the above patent documents and similar devices with test strips can be applied to the test element or the test cartridge of the present invention for detecting an analyte, such as an analyte in a sample.

The test strips used in the present invention may be so-called Lateral flow test strips (Lateral flow test strips), and the specific structure and detection principle of these test strips are well known in the art. A typical test strip comprises a sample collection area or application area, a labeling area comprising a label pad, a detection area comprising a bibulous pad, and a bibulous area comprising the necessary chemicals to detect the presence of the analyte, such as immunological or enzymatic reagents. A commonly used detection reagent strip is a nitrocellulose membrane reagent strip, that is, a detection area comprises a nitrocellulose membrane, and a specific binding molecule is fixed on the nitrocellulose membrane to display a detection result; it may be a cellulose acetate film, a nylon film, etc., and it may also include a detection result control region downstream of the detection region, and usually, the control region and the detection region are in the form of a transverse line, which is a detection line or a control line. Such test strips are conventional, but other types of test strips that utilize capillary action for testing are also contemplated. In addition, typically, the test strip has a dry chemical reagent component, such as an immobilized antibody or other reagent, which when exposed to a liquid, flows along the test strip by capillary action, and as it flows, the dry reagent component is dissolved in the liquid, and the next zone is processed to react the dry reagent in that zone, thereby performing the necessary test. The liquid flow is mainly by capillary action. The present invention can be applied to a test cartridge, or can be disposed in a test chamber to contact a liquid sample, or can be used to detect the presence or quantity of an analyte in a liquid sample entering the test chamber.

In addition to the test strips described above or the lateral flow test strip itself being used to contact a liquid sample to test for the presence of an analyte. In some preferred forms, the test elements may also be provided on some carriers, such as carrier 40 shown in fig. 1, which have a plurality of recesses 43 therein, the test elements being located in the recesses 43. In some embodiments, carrier 40 includes a recessed area for receiving test elements, where a plurality of recesses are provided, each of which may receive a test strip, each of which may detect an analyte. As shown in fig. 1-3 in particular, carrier 40 is configured to mate with collection chamber 22, and when collection chamber 22 is square, a square carrier can be disposed within collection chamber 22, and a plurality of recesses 43 are disposed on an outer surface of carrier 40, and a test element, which can be a test strip, is disposed within recesses 43. The groove 43 is internally provided with an installation sharp corner 45, so that the test strip can be clamped when being installed, and the test strip is prevented from falling off. In some embodiments, after the test elements are disposed in the recesses of the carrier, the carrier is covered with a transparent film, which seals the recess area of the carrier and facilitates viewing of the test results on the final test area. The transparent film may also be a transparent plastic sheet, transparent only in the test area.

Typically, the test strip includes a sample application area, a labeling area and a detection area, the sample application area being positioned adjacent to the bottom of the carrier and slightly exposing the recess, for example 2-3 mm, when the test strip is placed, with a portion of the sample application area reserved to absorb liquid sample that has flowed into the bottom of the collection well. Typically, the sample application zone is located upstream of the labeling zone, which is located upstream of the detection zone.

Carrier and collection chamber

The collection chamber is a place for containing a sample, and as shown in fig. 1-3, a collection chamber 22 is provided in the body 20, the collection chamber 22 includes an opening at an upper side of the body 20, and the carrier 40 is inserted into the collection chamber 22 from the opening at the upper side of the body 20. In some forms, carrier 40 mates with collection chamber 22. Specifically, when the collection chamber 22 is square, a square carrier 40 can be placed in the collection chamber 22, the upper end of the carrier 40 protrudes outwards to form a first boss 42, the first boss 42 is attached to the inner wall of the collection chamber 22, so that the carrier 40 cannot shake after being loaded into the collection chamber 22, a limit buckle 25 is arranged in the collection chamber 22, after the carrier 40 is completely inserted into the collection chamber 22, the carrier 40 is blocked by the limit buckle 25 and is not easy to fall out of the collection chamber 22, in the process of inserting the carrier 40 into the collection chamber 22, the first boss 42 collides with the limit buckle 25, for the convenience of inserting the carrier 40 into the collection chamber 22, referring to fig. 7 and fig. 12, the lower end of the first boss 42 is an inclined plane, correspondingly, the upper side surface of the limit buckle 25 is arc-shaped or inclined plane, for the difficulty of falling out of the carrier 40 from the collection chamber 22, the upper end of the first boss 42 is a plane, in order to prevent the carrier 40 from being inserted into the collection chamber 22 and, the lower side surface of the limit buckle 25 is an inclined plane, in addition, as shown in fig. 1, the bottom of the carrier 40 is provided with a second boss 46, correspondingly, as shown in fig. 5, the bottom of the collection cavity 22 is provided with a support member 29, the second boss 46 is in a square frame shape, the support member 29 is arranged at four corners of the bottom of the collection cavity 22 to support four corners of the second boss 46, the limit buckle 25 and the support member 29 respectively limit the carrier 40 from the upper side and the lower side, so that the carrier 40 is not easy to shake in the collection cavity 22. In some preferred manners, the lateral surface of the second boss 46 has a slope, and the square area of the lower portion of the second boss 46 is smaller than the square area of the upper portion of the second boss 46, so that the second boss 46 can be inserted between the supporting members 29 more easily, and a pre-tightening force is generated between the second boss 46 and the supporting members 29, so that the carrier 40 is installed in the collecting cavity 22 and is not easy to fall off.

The outer surface of the carrier 40 is uniformly distributed with grooves 43, the grooves 43 are internally provided with test elements, the carrier can be provided with a function of extruding a sample collector and sending a sample into a collection cavity besides the test elements, specifically, as shown in fig. 1-3, the carrier 40 is barrel-shaped, the upper side position is provided with an opening, the sample collector 30 is inserted into the carrier 40 along the opening on the upper side of the carrier 40 and extrudes with the bottom of the carrier 40, the sample is extruded from the sample collector and enters the space inside the carrier 40, the bottom of the carrier 40 is provided with a plurality of through holes 44, so that the space inside the carrier 40 is communicated with the collection cavity 22, the grooves 43 are internally provided with test paper, the lower end of the test paper is contacted with the bottom of the collection cavity 22 or is very close to the bottom of the collection cavity 22, and the sample inside the carrier 40 flows into the collection cavity 22 through.

A sampling hole 26 is formed in the bottle body 20 near the bottom, and as shown in fig. 3 and 10, the sampling hole 26 is used for performing a secondary sampling and retesting on the liquid sample. The sampling hole 26 is arranged on the side surface of the bottle body 20 (the collection cavity 22) near the corner position, because the carrier 40 is square under the condition that the bottle body 20 is square, the corner position of the carrier 40 is not provided with a slot for installing a test strip or a test element, the sample application area of the test strip or the test element can be prevented from blocking the sampling hole 26, and meanwhile, the sample is prevented from being polluted during secondary sampling by adopting a mode of directly extracting the sample from the sampling hole 26 of the bottle body 20. In some embodiments, the sampling hole 26 is provided with a sampling plug 27, and particularly as shown in fig. 4, the sampling plug 27 can prevent the liquid sample from flowing out of the sampling hole 26. In some preferred forms, the bottom of body 20 is provided with a chute 28 at the location where sampling plug 27 is fitted, chute 28 facilitating removal of sampling plug 27 by an inspector.

The upward protrusion 438 at the bottom of the bottle body 20 can disperse the liquid sample in the collection cavity 22 to the periphery, and fully contact with the test paper, so that the quantity of the liquid sample can be reduced on the premise of not influencing the detection result.

Analyte substance

Examples of analytes that can be used in the present invention include small molecule substances, including drugs of abuse (e.g., drugs of abuse). By "drug of abuse" (DOA) is meant the use of a drug (usually acting to paralyze nerves) at a non-medical destination. Abuse of these drugs can result in physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (e.g., black americane, white amphetamine tablets, dextroamphetamine tablets, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturate BAR (e.g., Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleep-aid drugs); lysergic acid diethylamide (LSD); inhibitors (downs, goofballs, barbs, blue devils, yellow jacks, hypnones); tricyclic antidepressants (TCAs, i.e., imipramine, amitriptyline and doxepin); dimethyldioxymethylaniline MDMA; phencyclidine (PCP); tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e., morphine, or opiates, cocaine, COC; heroin, dihydrocodeinone); anxiolytic and sedative hypnotic, anxiolytic is a kind of mainly used for relieving anxiety, stress, fear, stabilize mood, have hypnotic sedative effects at the same time, including benzodiazepine BZO (benzodiazepines), atypical BZ, fuse dinitrogen NB23C, benzodiazepine, BZ receptor ligand, ring-opening BZ, diphenylmethane derivatives, piperazine carboxylate, piperidine carboxylate, quinazolone, thiazine and thiazole derivatives, other heterocycles, imidazole type sedative/analgesic (such as dihydrocodeinone OXY, methadone MTD), propylene glycol derivative-carbamate, aliphatic compound, anthracene derivatives, etc.. The detection kit of the utility model can also be used for detecting the detection which belongs to the medical application and is easy to take excessive medicine, such as tricyclic antidepressant (imipramine or analogue), acetaminophen, etc. After being absorbed by human body, the medicines are metabolized into small molecular substances, and the small molecular substances exist in body fluids such as blood, urine, saliva, sweat and the like or exist in partial body fluids.

For example, analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic gonadotropin, progesterone hormone, follicle stimulating hormone, etc.), blood, leukocytes, sugars, heavy metals or toxins, bacterial material (e.g., proteins or carbohydrate material directed against specific bacteria, such as, for example, Escherichia coli 0157: H7, staphylococci, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Cactus), and substances associated with physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemical analysis can all utilize the cooperation of side direction crossing current detection form the utility model discloses the device detects.

Flow of liquid

The flow of liquid usually refers to a flow from one place to another, and in general, the natural liquid flow mostly depends on gravity from high to low, and the flow here also depends on external force, i.e. the flow under the external gravity condition, and can be the natural gravity flow. In addition to gravity, the flow of liquid may also overcome gravity and move from low to high. For example, the liquid is pumped, or the liquid is compressed, or the liquid is pressurized and flows from the bottom to the top, or the pressure is concerned and flows by the gravity of the liquid itself. For example, the liquid sample in the carrier 40 will enter the collection chamber 22 through the through hole 44 at the bottom of the carrier 40 under the action of gravity, and the liquid sample will start to flow from bottom to top by capillary force contacting the lower end of the test strip on the carrier 40.

Sample collector

The sample collector is used for collecting samples, and specifically, as shown in fig. 6, the sample collector 30 includes a connection end 31, a rod 32, and a sampling end 33, the connection end 31 includes a cross connection head 34 and a pressing table 37, the end of the cross connection head 34 is gradually tapered to facilitate the connection of the cross connection head 34 with the cover 10, the sampling end 33 is used for connecting an absorption element, the absorption element may be a nontoxic sponge with strong water absorption, the absorption element and the sampling end 33 can be bonded by special glue, an annular groove 35 is formed on the connection end 31, a sealing ring 36 is installed in the annular groove 35, when the sample collector 30 is inserted into the carrier 40 along the opening on the upper side of the carrier 40, the absorption element (not shown) on the sampling end 33 is pressed against the bottom of the carrier 40, the samples are extruded from the absorption element, the samples in the carrier 40 enter the collection cavity 22 through the through holes 44, until the sample collector 30 is completely inserted into the carrier 40, the sealing ring 36 on the connecting end 31 of the sample collector 30 is attached to the inner wall of the collection chamber 22 to form a sealing area, which can prevent the liquid sample from leaking out of the collection chamber 22 or from the carrier 40 when the detection box is violently shaken or turned upside down. In fact, the absorbing element contacts the bottom of the carrier, so that the absorbing element is compressed, the collected liquid sample, such as saliva sample, flows into the bottom of the collecting cavity through the through hole 44, the absorbing element needs to be continuously squeezed in the process, meanwhile, the sealing ring needs to contact the side wall of the collecting cavity, the sealing state is always kept, the sample collector always maintains the state by the mode that the detecting box covers the collecting cavity through the cover body, and therefore, the cover body and the collecting cavity are not easy to fall off. The use of a threaded structure is one way, but the threads need to be rotated in a relatively long time. The structure of the device in which the invention is particularly adapted will be elucidated and described in detail below.

Here, the absorption element is intended to absorb a liquid sample, such as saliva, urine, sweat or other samples. The material of the absorbent member may be any absorbent material, such as a sponge.

Cover and collection cavity

The cover body is used for sealing the collection cavity and preventing the sample in the collection cavity from leaking out, and is particularly shown in fig. 3 and 7. Be provided with in the body 20 and collect chamber 22, collect chamber 22 and be used for collecting the fluid sample, still have test element in collecting chamber 22, whether there is analyte matter in the fluid sample for testing, collect chamber 22 and include the opening of body 20 upside position, lid 10 is used for the lid to close and collects chamber 22 opening, wherein, lid 10 and collection chamber 22 phase-match, when collecting chamber 22 and being square, lid 10 also is square, be equipped with the buckle structure 12 that is used for the joint to collect chamber 22 in the lid 10, when lid 10 lid closed and collects chamber 22 opening, lid 10 passes through buckle structure 12 joint and collects chamber 22 open-ended outer wall, thereby let lid 10 fix on collecting chamber 22. In some approaches, the collection chamber includes a carrier on which a plurality of test elements are disposed. As previously described, the carrier is positioned in the collection chamber and the sample collector with the absorbent member is attached to the cover such that during closure of the collection chamber by the cover, the absorbent member contacts the bottom of the carrier, allowing the absorbent member to be compressed to express the liquid sample so that the liquid sample flows into the bottom of the collection chamber and into contact with the test element at the bottom of the collection chamber. A test element is disposed within the channel of the carrier, the test element including a sample application zone, a labeling zone, a detection zone, and an absorption zone. Typically, the sample application area of the test element is located at the bottom of the collection chamber to receive the liquid sample. Thus, a portion of the liquid sample flows over the test element by capillary force, completing the analyte test.

The outer wall of the collection cavity 22 comprises a protruding structure 21, and when the cover body 10 covers the opening of the collection cavity 22, the buckling structure 12 is buckled with the protruding structure 21. The snap-fit means here that the cap 10 cooperates with the collection chamber 22 in a similar "plug-in" or "piston-like" manner, by means of a snap-fit. The manner of clamping is opposite to the manner of screw rotation. The thread pattern requires relative rotation and then the cap and collection chamber are brought together.

In some preferred modes, as shown in fig. 11, the fastening structure 12 includes a lower fastening surface 13 and an upper fastening surface 14, an angle (angle 2) between the lower fastening surface 13 and a horizontal plane is greater than an angle (angle 1) between the upper fastening surface 14 and the horizontal plane, so that a slope of the lower fastening surface 13 is greater than a slope of the upper fastening surface 14, when the cover 10 and the collecting cavity 22 need to be covered, since the slope of the lower fastening surface 13 is greater, the process of covering the cover 10 and the collecting cavity 22 is relatively easy due to the contact between the lower fastening surface 13 and the protrusion structure 21, and a process of elastic deformation occurs slowly, so that a small force is required. The feeling when the operator is buckled is embodied as follows: can be buckled by lightly pushing. When the cover 10 needs to be separated from the collecting cavity 22, the process of separating the cover 10 from the collecting cavity 22 is relatively difficult due to the small slope of the fastening surface 14 and the contact between the fastening surface 14 and the protrusion structure 21, and mutually, the process of rapidly generating elastic deformation is realized by the feeling that the operator separates: a large force is required to separate. As will be described in more detail below.

Thus, as shown in FIG. 3, when the cover 10 is provided with the sample collector 30, the sample collector 30 is provided at one end with an element for collecting a fluid sample, such as an absorbent element, which is generally stiff when dry and becomes soft when exposed to liquid, such as saliva or urine. During the process of covering the opening of the collection chamber 22 with the cover 10 having the absorbent member, the sample collector 30 is gradually inserted into the collection chamber 22, the absorbent member contacts the pressing surface (the bottom of the carrier 40), and as the cover 10 is further inserted, the cover 10 continues to approach the opening of the collection chamber 22, during which the absorbent member is pressed, the liquid of the absorbent member is released, and the cover 10 continues to approach the opening of the collection chamber 22 until the protrusion 21 on the outer wall of the collection chamber 22 contacts the lower fastening surface 13 of the fastening structure 12. As shown in fig. 7 and 11, in the next stage, the cap body 10 and the collection cavity 22 are elastically deformed, the position of the latch structure 12 on the cap body 10 is slightly expanded outwards, and correspondingly, the position of the protrusion structure 21 on the collection cavity 22 is pressed inwards, the degree of deformation depends on the thickness of the latch structure 12 on the cap body 10 and the thickness of the protrusion structure 21 on the bottle body 20, and the thicker the thickness the smaller the degree of deformation, the more difficult the deformation; the thinner the thickness, the greater the degree of deformation, the easier the deformation, and in order to facilitate the closure between the cap body 10 and the collection cavity 22, the cap body 10 and the bottle body 22 can be made of plastic with stronger plastic deformation capability. The cover 10 and the collection chamber 22 are continuously elastically deformed until the collection chamber 22 slides over the lower fastening surface 13 and enters the upper fastening surface 14, the protrusion 21 of the collection chamber 22 contacts the upper fastening surface 14, during the next period, the position of the fastening structure 12 on the cover 10 is contracted inward, the position of the protrusion 21 on the collection chamber 22 is expanded outward, until the cover 10 and the collection chamber 22 are restored to the original state, at which time, the cover 10 and the collection chamber 22 are completely closed, in which state, the absorption element is always in a compressed state, and transmits a force separating from the collection chamber 22 to the cover 10 through the sample collector 30, wherein the sealing ring 36 in the sample collector 30 contacts the inner wall of the collection chamber 22, and can counteract a part of the separating force, but in general, the separating force cannot be completely counteracted, but due to the smaller slope of the upper fastening surface 14, the separation of the upper snap surface 14 from the raised structure 21 requires a large force, so that the cover 10 and the collecting chamber 22 cannot be deformed by the force of the absorption element alone, but the separation force makes the raised structure 21 of the collecting chamber 22 and the upper snap surface 14 contact more tightly or firmly, and at this time, the cover 10 is not easily separated from the opening of the collecting chamber 22, and the cover 10 does not shake on the collecting chamber 22. In this way it is ensured that the absorbent member is always in a compressed state, which allows for a continuous release of the liquid sample into the collection chamber 22. The elastic deformation is very small, and in the actual use process of the test box, the buckling process is very short and is difficult to observe by naked eyes, but the matching relationship between the elastic deformation and the buckling process can be reflected by the hand feeling when the elastic deformation is buckled and separated, namely: can be buckled by slight pushing and can be separated by using larger force.

In some forms, in order to facilitate the sliding of the raised structure 21 on the outer wall of the collection chamber 22 into the cover 10 to cover, the lower fastening surface 13 may be smooth and have a certain curvature, and accordingly, the raised structure 21 preferably has a smooth surface, and the two smooth surfaces are in sliding engagement to reduce friction, so that the cover 10 can be engaged with the collection chamber 22 with little effort.

In some embodiments, as shown in fig. 11, the protrusion structure 21 includes an upper convex surface 70 and a lower convex surface 71, when the cover 10 is in a closed state with the collection cavity 22, the lower convex surface 71 of the protrusion structure 21 is in close contact with the fastening surface 14 of the fastening structure 12, when the fastening surface 14 is at a certain angle with the horizontal plane (angle 1), the lower convex surface 71 should also be at a certain angle with the horizontal plane (angle 3), and when the collection cavity 22 is in close contact with the cover 10 for closing, the angle of the angle 3 is equal to angle 1, when the plane of the fastening surface 14 is perpendicular to the central axis of the cover 10, the corresponding lower convex surface 71 of the protrusion structure 21 should also be perpendicular to the central axis of the cover 10, and when the lower convex surface 71 of the collection cavity 22 is in close contact with the fastening surface 14, the cover 10 tightly clamps the collection cavity 22, in which case it is difficult to separate the cover 10 from the collection cavity 22. In a preferred mode, during the process of covering the cover 10 and the collecting cavity 22, the upper convex surface 70 will contact with the lower buckling surface 13 to cause the cover 10 and the collecting cavity 22 to elastically deform, and in order to make the covering process easier, the surface of the upper convex surface 70 may be smooth, or the plane of the upper convex surface 70 may form an angle (angle 4) with the horizontal plane. In some embodiments, the upper fastening surface 14 intersects with the lower fastening surface 13 or the extension surface of the upper fastening surface 14 intersects with the extension surface of the lower fastening surface 13, and the length of the lower fastening surface 13 is longer than that of the upper fastening surface 14, so that the protruding structure 21 of the collecting cavity 22 is more easily slid into the cover 10, the cover 10 is slowly deformed outward, and when the protruding structure 21 slides into the upper fastening surface 14, due to the relative short distance of the upper fastening surface 14 and the resilience of the cover 10 and the collecting cavity 22, the collision between the protruding structure 21 and the fastening structure 12 generates a crisp sound to remind the cover 10 and the collecting cavity 22 to be closed.

In some embodiments, to ensure that the cover 10 can be more firmly fitted or covered with the collection chamber 22, at least two or more than three snap structures 12 are provided in the cover 10. In some embodiments, referring to fig. 8-9, the cover 10 is generally square, and the four corners of the cover 10 are provided with the fastening structures 12, wherein the fastening structures 12 are right-angled. Meanwhile, the outer wall of the collecting cavity 22 is provided with a square protruding structure 21, and the protruding structure 21 is matched with the four buckling structures 12, so that when the collecting cavity 22 is opened by the cover body 10, the cover body 10 is not easy to separate from the collecting cavity 22. The primary purpose of this is that when the sample collector 30 has a resilient sealing ring 36 thereon, the sample collector 30 is inserted into the collection chamber 22, and the sealing ring 36 cooperates with the inner wall of the collection chamber 22 to form a sealing area, thereby minimizing leakage of the liquid sample within the collection chamber 22 or within the carrier 40. Due to the sealing engagement of the sealing ring 36 with the inner wall of the collection chamber 22, it is more desirable that the cap 10 and the collection chamber 22 are longitudinally closely engaged to avoid separation of the cap 10 from the collection chamber 22. In some other embodiments, the snap structure 12 is disposed on the inner wall of the cover 10 near the bottom position, and the snap structure 12 is in a straight line.

In some embodiments, as shown in fig. 8 to 9, a position-limiting clamping strip 15 is provided in the cover 10, and the position-limiting clamping strip 15 includes two parts: first spacing position 81 and second spacing position 82, when lid 10 and collection chamber 22 are in the lid and close the state, second spacing position 82 and buckle structure 12 can be followed the upper and lower side respectively and spacing to the protruding structure 21 on the collection chamber 22 outer wall, make lid 10 keep stable on body 20, and first spacing position 81 can make lid 10 and the opening of collecting chamber 22 keep in touch, makes body 20 upper end embedding unable the rocking in lid 10. In some preferred modes, the position limiting clamping strips 15 are arranged on the inner wall of the square cover body 10 and on the corner positions.

Foretell lid 10 and collection chamber 22's lid closed the mode and traditional lid 10 and collect chamber 22 screw thread rotation mode and all have easy and simple to handle, extrude the advantage that absorbs the component, improve detection efficiency, but relatively speaking, in repeated many times's testing process, the rotatory mode of screw thread compares the utility model provides a technical scheme is many more loaded down with trivial details, is difficult to operate. The utility model discloses a detect box aim at obtains preliminary testing result fast, "fast", "convenient" is the utility model discloses a detect the required primary requirement that reaches of box.

In some modes, as shown in fig. 8, since the cover body 10 and the collection cavity 22 are tightly covered, the cover body 10 and the collection cavity 22 are not conveniently separated, a holding portion 83 is arranged on the cover body 10, the holding portion 83 facilitates an operator to exert force on the cover body 10, the holding portion 83 and the cover body 10 are integrally formed, processing is convenient, the lower portion of the holding portion 83 is hollow, and the overall weight of the detection box can be reduced.

In some embodiments, the cap body 10 is provided with a hollow connecting portion 80, the hollow connecting portion 80 is used for connecting the sample collector 30, the cross-shaped connector 34 can be inserted into the hollow connecting portion 80 by pressing the pressing platform 37 with the index finger and the middle finger, so as to complete the connection between the cap body 10 and the sample collector 30, when the cap body 10 and the collection cavity 22 are in the covering state, the absorption element in the sample collector 30 is in the compressed state, and at this time, a force for separating the cap body 10 from the collection cavity 22 is generated, but since the force generated when the absorption element is compressed is very small and is much smaller than the force required for separating the cap body 10 from the collection cavity 22, the snap structure 12 and the bulge structure 21 cannot be separated.

The above description is only the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through creative work should be covered within the protection scope of the present invention, and therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

The utility model shown and described herein may be implemented in the absence of any element, limitation, or limitations specifically disclosed herein. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, and it is recognized that various modifications are possible within the scope of the invention. It should therefore be understood that although the present invention has been specifically disclosed by various embodiments and optional features, modification and variation of the concepts herein described may be resorted to by those skilled in the art, and that such modifications and variations are considered to be within the scope of this invention as defined by the appended claims.

The contents of the articles, patents, patent applications, and all other documents and electronically available information described or cited herein are hereby incorporated by reference in their entirety to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. Applicants reserve the right to incorporate into this application any and all materials and information from any such articles, patents, patent applications, or other documents.

Claims (15)

1. A test kit is characterized by comprising a fluid sample collection cavity, a test kit and a detection device, wherein the collection cavity comprises an opening, a test element is arranged in the collection cavity, and the test element is used for testing whether an analyte exists in a fluid sample or not; the detection box also comprises a cover body for covering the opening of the collection cavity;

wherein, the lid is including being used for the joint to collect the open-ended buckle structure of chamber, and when the lid closed and collects the chamber open-ended, the open-ended outer wall in chamber is collected to buckle structure joint to let the lid fix on collecting the chamber.

2. The detecting box according to claim 1, wherein the outer wall of the collecting cavity includes a protrusion structure, and the fastening structure is engaged with the protrusion structure when the cover body covers the opening of the collecting cavity.

3. The detecting box of claim 1, wherein at least two fastening structures are provided in the cover.

4. The detecting box of claim 1, wherein the snap structure is a right angle or a straight line.

5. The detecting box according to claim 1, wherein the cover body is provided with a grip portion, the grip portion is formed integrally with the cover body, and a lower portion of the grip portion is hollow.

6. The cartridge according to claim 1, wherein the bottom of the collection chamber is upwardly convex.

7. The detecting box of claim 2, wherein the fastening structure comprises a lower fastening surface and an upper fastening surface, and the angle between the lower fastening surface and the horizontal plane is larger than the angle between the upper fastening surface and the horizontal plane.

8. The detecting box according to claim 2, wherein a position-limiting clamping strip is arranged in the cover body, the position-limiting clamping strip comprises a first position-limiting part and a second position-limiting part, the first position-limiting part limits the protruding structure, and the second position-limiting part limits the opening of the collecting cavity.

9. The testing cassette of claim 2, wherein the bottom button surface is a smooth surface and the protrusion on the collection well comprises an upper convex surface and a lower convex surface, wherein contact between the upper convex surface and the bottom button surface guides the lower convex surface into contact with the top button surface.

10. The detecting box according to claim 8, wherein the cover is square, and the position-limiting holding strip is provided on the inner wall of the cover and at the corner of the cover.

11. The detecting box according to claim 10, wherein the collecting chamber has a square shape, and a sampling hole is provided on a side surface of the collecting chamber near a corner portion.

12. The testing cassette of claim 1, further comprising a carrier having a plurality of slots for receiving the testing elements, the carrier being disposed in the collection chamber, the carrier having a cavity therein, the carrier having a bottom, the bottom of the carrier having a through hole.

13. The testing cassette of claim 12, wherein the cover further comprises a sample collector disposed thereon, the sample collector adapted to be inserted into the cavity in the carrier and to contact the bottom of the carrier.

14. The testing cassette of claim 12, wherein the sample collector defines an annular groove, and wherein the annular groove is configured to receive a sealing ring, the sealing ring being configured to seal with the collection well.

15. The detecting box of claim 12, wherein the bottom of the carrier is provided with a second boss, the second boss is in a shape of a square frame, and the bottom of the collecting cavity is provided with a supporting member, and the supporting member supports four corners of the second boss.

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