CN108742655A - Whole blood HIV detection devices and application method - Google Patents
Whole blood HIV detection devices and application method Download PDFInfo
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- CN108742655A CN108742655A CN201810403999.2A CN201810403999A CN108742655A CN 108742655 A CN108742655 A CN 108742655A CN 201810403999 A CN201810403999 A CN 201810403999A CN 108742655 A CN108742655 A CN 108742655A
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- 239000008280 blood Substances 0.000 title claims abstract description 87
- 210000004369 blood Anatomy 0.000 title claims abstract description 87
- 238000001514 detection method Methods 0.000 title claims abstract description 64
- 238000000034 method Methods 0.000 title claims abstract description 12
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 139
- 229960002897 heparin Drugs 0.000 claims abstract description 139
- 229920000669 heparin Polymers 0.000 claims abstract description 139
- 239000007853 buffer solution Substances 0.000 claims abstract description 94
- 238000010241 blood sampling Methods 0.000 claims abstract description 34
- 238000012360 testing method Methods 0.000 claims abstract description 26
- 239000005030 aluminium foil Substances 0.000 claims description 15
- 238000007789 sealing Methods 0.000 claims description 11
- 230000007704 transition Effects 0.000 claims description 6
- 235000013399 edible fruits Nutrition 0.000 claims description 5
- 238000011010 flushing procedure Methods 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 210000002615 epidermis Anatomy 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 28
- 239000000523 sample Substances 0.000 description 21
- 238000010586 diagram Methods 0.000 description 16
- 239000007788 liquid Substances 0.000 description 6
- 238000009434 installation Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000005452 bending Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses whole blood HIV detection devices, including detecting box, it detects and is equipped with blood taking needle, heparin tube and buffer solution apparatus for placing in box, heparin tube is transparent tube body, test paper is equipped in heparin tube, it is not contacted using preceding blood taking needle and heparin tube and buffer solution apparatus for placing, heparin tube and buffer solution apparatus for placing combine outside detection box when use, are enclosed in detection box using the combination of rear heparin tube and buffer solution apparatus for placing；It is described book within/on detection box；It includes box body and box cover to detect box, and buffer solution apparatus for placing is fixed in box cover, and heparin tube is placed in box body, and blood taking needle is mounted on box body；Heparin tube one end is equipped with blood sampling head, and blood sampling head is externally provided with heparin tube lid, and the heparin tube other end is equipped with the first mounting base, mounting blocks are equipped in box body.The invention also discloses the application methods of the device.The present invention is a kind of HIV detection kits of safety and good leak tightness, collection blood sampling and is detected on one, can unitary closed abandon, sample secondary pollution can be effectively prevent.
Description
Technical field
The present invention relates to whole blood HIV detection devices and application methods.
Background technology
The detection of whole blood HIV has begun universalness, on the market existing many simple efficiently kits, but existing skill
Kit in art usually only includes the contained structure of test paper and test paper, and blood taking needle, heparin tube and the buffer solution for running plate
It all in addition individually packs, usually the kit after use has been contaminated, and is needed isolation to abandon, is prevented secondary dirt
Dye, and according to existing product for, be all exposed discarding, have no safeguard procedures, especially in the case of non-medical (such as
Self-test), the phenomenon that being abandoned as common rubbish, be just easy to generate secondary pollution.
Invention content
Present invention technical problems to be solved first are to provide a kind of whole blood HIV detection devices, by blood taking needle, heparin tube,
Test paper and buffer solution are integrated in a device, whole to be abandoned using whole, prevent secondary pollution.
Technical solution is used by the present invention solves above-mentioned technical problem：
Whole blood HIV detection devices, including box is detected, being integrated with blood taking needle, heparin tube and buffer solution in detection box holds dress
It sets, heparin tube is transparent tube body, and test paper is equipped in heparin tube, not using preceding blood taking needle and heparin tube and buffer solution apparatus for placing
Contact, heparin tube and buffer solution apparatus for placing combine outside detection box when use, use rear heparin tube and buffer solution apparatus for placing
Combination be enclosed detection box in.
Further, it is integrated with specification within/on detection box.
Further, detection box includes box body and box cover, and buffer solution apparatus for placing is fixed in box cover, and heparin tube is placed on
In box body, blood taking needle is mounted on box body.
Further, one end of heparin tube is equipped with blood sampling head, and blood sampling head is externally provided with heparin tube lid, and the other end of heparin tube is set
There is the first mounting base, is equipped with the mounting blocks coordinated with the first mounting base in box body, the first mounting base can be set on mounting blocks.
Further, the second mounting base is equipped in box cover, the second mounting base is equipped with trepanning, the installation of buffer solution apparatus for placing
In the trepanning.
Further, buffer solution apparatus for placing is equipped with opening, and opening is equipped with aluminium foil sealing, and aluminium foil sealing is by buffer solution
It encapsulates in it.
Further, the length in the one of direction of heparin tube lid is more than buffer solution apparatus for placing and is open in the same direction
On length.
Further, the opening shape of the cross sectional shape of heparin tube and buffer solution apparatus for placing matches, when heparin tube stretches into
When in buffer solution apparatus for placing, outer surface can be with the opening close-fitting of buffer solution apparatus for placing.
Further, specification can be bent, is bent or be rolled into the shape consistent with inboard wall of cartridge and be placed on box
Between body and heparin tube.
Further, blood sampling head is capillary suction nozzle, and heparin tube is in flat, takes a blood sample and is equipped with the first mistake between head and heparin tube
Inclined-plane is crossed, sample working area is equipped in First Transition inclined-plane；The second intermediate incline is equipped between heparin tube and the first mounting base, the
The end face of one mounting base is equipped with shirt rim.
The present invention also provides a kind of application method of above-mentioned whole blood HIV detection devices,
It follows the steps below：
(1) detection box is opened, the box cover with buffer solution apparatus for placing is detached with box body；
(2) heparin tube being placed in box body is taken out, the blood taking needle for being placed in box body edge is exposed；
(3) finger is pressed on blood taking needle surface, punctures finger skin to can extrude out blood；
(4) lid for removing blood sampling tube head is squeezed at the finger epidermis being punctured extremely with the capillary blood sampling head of heparin tube
It is drawn to the blood of sufficient amount；
(5) after the completion of taking a blood sample, heparin tube is inserted into the buffer solution apparatus for placing in box cover, is pierced with the end of heparin tube
The encapsulated layer of broken buffer solution apparatus for placing makes capillary blood sampling head enter absorption buffer solution in buffer solution and carries out race plate；
(6) hardened fruit will be run and standard is compared, judge testing result；
(7) box cover with heparin tube is fastened on box body, so that heparin tube is closed in detection box, abandons.
During entire use, manual blood collection is not needed, buffer solution need not manually be added dropwise, passes through matching in structure
It closes, realizes automatic blood sampling, runs plate automatically, after detection, heparin tube and test paper need not be touched again, holding box cover can incite somebody to action
The waste containing detection sample such as heparin tube after use is encapsulated into detection box, it is ensured that not will produce secondary dirt after discarding
Dye.
For the testing staff of profession, the present invention obviously there is higher safety to be not necessarily to because in whole operation
Drop of blood is taken to add, testing staff will not
The beneficial effects of the invention are as follows：
(1) blood taking needle, heparin tube and buffer solution apparatus for placing are integrated in a box body by the present invention, and whole Transporting is whole
Carry whole use, it is ensured that each functional parts will not be lost.
(2) buffer solution apparatus for placing of the invention is integrated on box cover, and when use stretches into heparin tube wherein, heparin tube energy
Enough and buffer solution apparatus for placing close-fitting forms an entirety, can be integrally put into box body after use, box body and box cover are closed it
Afterwards, wherein by used heparin tube and test paper closing, it abandons again later, secondary pollution would not be generated.
(3) specification of the invention is also integrated in box body or on box body, and when use can directly carry out observation comparison, and
Do not allow easy to be lost.
(4) test paper is encapsulated in heparin tube by the present invention, and heparin tube will be adopted while by capillary suction nozzle, blood was collected
The blood sample of collection is stored in working area, and working area is stretched at the sample introduction end of test paper, and after the completion of blood sampling, heparin tube is extend into buffering
Draw buffer solution in liquid apparatus for placing, then carry out race plate, need not into test paper dropping liquid or transfer sample, avoid sample
Secondary pollution in transfer process, it is ensured that inspection result is accurate.
(5) the buffer solution apparatus for placing equipped with buffer solution is integrated on box cover by the present invention, box cover and the removable company of box body
It connects, the opening of buffer solution apparatus for placing is encapsulated using aluminium foil, can be punctured by hard object, is arranged with and adopt on the blood sampling head of heparin tube
Blood vessel lid, the size on one direction of heparin tube lid are more than the size of the opening same direction, under non-working condition, heparin tube
Blocked by heparin tube lid, aluminium foil encapsulation will not be punctured, after removing heparin tube lid, the blood sampling head of heparin tube can puncture aluminium foil into
Enter in buffer solution apparatus for placing, also, the tube body cross sectional shape of heparin tube, slightly larger than the shape of opening, such heparin tube is inserted into it
After can be with buffer solution apparatus for placing close-fitting.
(6) bottom of box body is equipped with mounting blocks, and the bottom of heparin tube is equipped with the first mounting base, and the first mounting base can be with peace
The installation of block close-fitting is filled, such as the first mounting base is socketed in by the way of interference fit above mounting blocks, in this way, before use, adopting
Blood vessel will be assembled on mounting blocks, will not be skidded off, and be both the positioning to heparin tube, while heparin tube can be prevented to box again
Lid moves over there, further protects the aluminium foil of buffer solution apparatus for placing, will not be just punctured when unused.
Description of the drawings
Fig. 1 is the monnolithic case figure of embodiment 1.
Fig. 2 is the exploded view of embodiment 1.
Fig. 3 is the schematic diagram that embodiment 1 opens the lid.
Fig. 4 is the schematic diagram that embodiment 1 takes out heparin tube.
Fig. 5 is the enlarged drawing of heparin tube one end in embodiment 1.
Fig. 6 is the schematic diagram that embodiment 1 opens heparin tube lid.
Fig. 7 is the installation site figure of blood taking needle in embodiment 1.
Fig. 8 is the internal structure chart of box cover in embodiment 1.
Fig. 9 is the schematic diagram of the buffer solution apparatus for placing of embodiment 1.
Figure 10 is the schematic diagram by buffer solution apparatus for placing after being taken out in box cover in embodiment 1.
Figure 11 is the schematic diagram that heparin tube is inserted into buffer solution apparatus for placing in embodiment 1.
Figure 12 is the schematic diagram that embodiment 1 releases specification.
Figure 13 is the schematic diagram of 1 blood taking needle of embodiment.
Figure 14 is the schematic diagram of 1 box body of embodiment.
Figure 15 is the sectional view after 1 use of embodiment.
Figure 16 is the monnolithic case figure of embodiment 2.
Figure 17 is the exploded view of embodiment 2.
Figure 18 is the schematic diagram that embodiment 2 opens the lid.
Figure 19 is the schematic diagram that embodiment 2 takes out heparin tube.
Figure 20 is the enlarged drawing of heparin tube one end in embodiment 2.
Figure 21 is the schematic diagram that embodiment 2 opens heparin tube lid.
Figure 22 is the installation site figure of blood taking needle in embodiment 2.
Figure 23 is the internal structure chart of box cover in embodiment 2.
Figure 24 is the schematic diagram of the buffer solution apparatus for placing of embodiment 2.
Figure 25 is the schematic diagram by buffer solution apparatus for placing after being taken out in box cover in embodiment 2.
Figure 26 is the schematic diagram that heparin tube is inserted into buffer solution apparatus for placing in embodiment 2.
Figure 27 is the sectional view after 2 use of embodiment.
Specific implementation mode
Technical scheme of the present invention is described in further detail below in conjunction with attached drawing, it is noted that embodiment is only
It is to be specifically described to the present invention, is not construed as limitation of the invention.
Since HIV is a kind of high mortality high-risk viral, and its detection sample may contain the infection sources, therefore to it
Wholesomeness, seal and safety have very high requirement, at present similar product on the market, most of or and common blood examination
Or the structure that urinalysis reagent box is similar, there is no this to HIV targetedly safe set is carried out by the virus of the infection sources of sample
Meter.And currently, HIV detections start to popularize, many kits can carry out self-test to user, rather than medicine is special
Industry personnel operate, the kit after detection, it is more likely that can arbitrarily be abandoned by layman, clinical waste is not achieved
Processing requirement, often mix discarding with common rubbish, this just easily causes the secondary pollution of sample, therefore,
There is an urgent need for the fabulous detection kit of a kind of safety and seal, pointedly to be used as HIV detection kits, so as to have
Effect prevents the secondary pollution of sample.The present invention is exactly the innovation carried out the defects of for the above-mentioned prior art.
Embodiment 1, with reference to attached drawing 1-15.
Whole blood HIV detection devices, including detection box detect in box as shown in Figs 1-4 and are integrated with blood taking needle 5, heparin tube 3
With buffer solution apparatus for placing 4, heparin tube 3 is transparent tube body, and test paper, blood taking needle 5 and heparin tube 3 are equipped in heparin tube 3 and is delayed
Fliud flushing apparatus for placing 4 place when do not contact, before use, by heparin tube 3 and buffer solution apparatus for placing 4 respectively with detection box
Box body 1 detach, heparin tube 3 and buffer solution apparatus for placing 4 combine outside the box body of detection box when use, use rear heparin tube 3
It is enclosed in detection box with the combination of buffer solution apparatus for placing 4, as shown in figure 15.
That is, the device of the invention contains blood taking needle 5, heparin tube 3, test paper and buffer solution apparatus for placing 4, by this
A little devices are all integrated in a detection box, and components and functionality is completely complete, can be incited somebody to action again by closed box body after use
These components polluted are all encapsulated into box body 1, prevent secondary pollution, also, the whole blood HIV detection devices of the present invention exist
In operation, blood sampling and dropping liquid need not be manually removed, blood sample and buffer solution enter the areas Pao Ban of test paper and carry out running plate complete
It can be realized by automatic mode, need not substantially be operated entirely, for commonly used person, wanted completely without profession
It asks, can easily realize exact operations, it is ensured that testing result is accurately and detection program closes rule.
As a preferred solution, as shown in Figs 1-4, detection box includes box body 1 and box cover 2, buffer solution apparatus for placing 4
It is fixed in box cover 2, as shown in Figure 8；Heparin tube 3 is placed in box body 1, and blood taking needle 5 is mounted on box body 1, as shown in Figure 3.
As a preferred solution, there are needle guard mechanisms, as shown in figure 13, needle guard mechanisms around blood taking needle 5
It higher than blood taking needle 5, can be pressed into less than blood taking needle 5, in use, pressing needle guard mechanisms, contact blood taking needle 5 by finger
It punctures, blood was collected；After blood sampling, needle guard mechanisms restore to original height, avoid human body by syringe needle unexpected injury；Syringe needle
Protective device is located in blood taking needle mounting base 21；21 side of blood taking needle mounting base is equipped with card slot 19, and 1 inside of box body is equipped with and card slot
The strip 20 of 19 shapes cooperation, as shown in figure 14；Blood taking needle 5 can be fixed on box body 1 by card slot 19 with the mutual cooperation of strip 20
It is interior.
As a preferred solution, buffer solution apparatus for placing 4 is equipped with opening, and opening is equipped with aluminium foil sealing, aluminium foil
Sealing encapsulates buffer solution in it.The leakproofness of aluminium foil sealing is good with shielding, has some strength, additionally it is possible to shading, it can
Buffer solution is preferably protected, the shelf-life of buffer solution is increased.
As a preferred solution, heparin tube 3 includes tube body 6, as shown in fig. 6, one end of heparin tube 3 is equipped with blood sampling head
7, blood sampling head 7 is externally provided with heparin tube lid 8；When being not used, heparin tube lid 8 covers blood sampling head 7, protects blood sampling head 7, in order to avoid blood sampling head
7 are compromised or pollute.
As a preferred solution, it as shown in fig. 6, the other end of heparin tube 3 is equipped with the first mounting base 9, is set in box body 1
There are the mounting blocks 10 coordinated with the first mounting base 9, as shown in figure 15, the first mounting base 9 can be set on mounting blocks 10.Do not make
Used time, the first mounting base mounting base 9 are interference fitted with the locating piece 10 in box body 1, to fixed heparin tube 3, will not be skidded off, both
It is the positioning to heparin tube, while can prevents heparin tube from being moved over there to box cover again, further protects buffer solution apparatus for placing
Aluminium foil, will not be just punctured when unused.
As a preferred solution, the second mounting base 17a, as shown in Figure 10, the second mounting base 17a are equipped in box cover 2
It is equipped with trepanning, buffer solution apparatus for placing 4 is mounted in the trepanning, as shown in Figure 9；After installation, as shown in figure 8, buffer solution is contained
The upper surface for putting device 4 and the upper surface of mounting ring 17a are in same plane；Be conducive to the close of buffer solution apparatus for placing 4 in this way
Envelope.
As a preferred solution, the opening shape of the cross sectional shape of heparin tube 3 and buffer solution apparatus for placing 4 matches,
When heparin tube 3 stretches into buffer solution apparatus for placing 4, outer surface can be with the opening close-fitting of buffer solution apparatus for placing 4；The two
Interference fit during use, when heparin tube 3 is inserted into buffer solution apparatus for placing 4, can form a sealing system, avoid
Buffer solution or blood sample splash out.
As a preferred solution, tube body 6 is in flat, as shown in Figure 5；Be conducive to place test paper, fixed test strips
Position, prevent test strips from arbitrarily being overturn in tube body 6, influence final testing result.
As a preferred solution, the length in 8 one of direction of heparin tube lid is open more than buffer solution apparatus for placing 4
Length in the same direction；Heparin tube lid 8 is inserted into the opening of buffer solution apparatus for placing 4 when avoiding being not used so that buffering
Liquid splashes out.
As a preferred solution, blood sampling head 7 is capillary suction nozzle, and heparin tube 3 is in flat, take a blood sample head 7 and heparin tube 3
Between be equipped with First Transition inclined-plane 5a, as shown in fig. 6, First Transition inclined-plane 5a in be equipped with sample working area；Capillary suction nozzle is drawn
After blood, blood storage is detected in sample working area with plate to be run.As shown in fig. 6, being set between heparin tube 3 and the first mounting base 9
There are the second intermediate incline 6a, the end face of the first mounting base 9 to be equipped with shirt rim.
As a preferred solution, as shown in figure 3, the 2 removable connection of box body 1 and box cover, box body 1 are equipped with linkage section
11 as shown in figure 14, and linkage section 11 is equipped with retainer ring 12, is equipped with the snap ring 13 coordinated with retainer ring 12 in box cover 2, as shown in Figure 10；
The closing face of box body 1 and box cover 2 is equipped with transition face 14, as shown in Figure 1；When box body 1 and box cover 2 are closed, need be closed
There are certain gaps on face, are convenient for box cover 2 to open in this way, if without gap, are not just done when opening the lid
Method applies box cover and box body separated power, and device is caused to be difficult with.
As a preferred solution, it detects in box and is integrated with specification 15, as shown in figure 12；Specification 15 includes explanation
Books body 17 and protrusion 16.
As a preferred solution, specification 15 can be bent, be bent or be rolled into the shape consistent with 1 inner wall of box body
And it is placed between box body 1 and heparin tube 3.
Specification ontology 17 is cylindrical in shape after being bent or curved in the present embodiment.
As a preferred solution, specification ontology 17 can be papery either plastics papery or other flat materials
Material, is put into after box body 1, will not occupy the space in box body 1, do not interfere with the placement of other articles box body 1 Nei.
As a preferred solution, protrusion 16 is arranged at the edge of an end face of tubular specification ontology 17, such as schemes
Shown in 12.
As a preferred solution, the protrusion direction of protrusion 16 is towards the inside of tubular specification ontology 17, such as Figure 12
It is shown；After specification is loaded into box body, smoothly specification can be picked up by protrusion 16.
As a preferred solution, it is as shown in figure 12 to be equipped with opening for the side of tubular specification ontology 17；Convenient for fixation
Specification.
As a preferred solution, the content recorded on specification includes：Product information illustrates, product operation illustrates,
Testing result explanation, product application notice.
As a preferred solution, the shape after the shape of 1 inner wall of box body is bent or curved with specification ontology 17
Unanimously；It is loaded into box body 1 convenient for specification ontology 17, specification ontology 17 is close to 1 inner wall of box body, it is possible to reduce illustrates books
17 occupied space of body.
Box body 1 is cylindrical in shape in the present embodiment.
As a preferred solution, 1 inner wall of box body is equipped with positioning strip 18, as shown in Fig. 7 and 14；Positioning strip 18 is along box body
The length direction of 1 inner wall is arranged, and positioning strip 18 is located at the opening of specification ontology 17 both sides.
As a preferred solution, positioning strip 18 can block the opening of specification ontology 17, prevent specification in box
Specification is maintained at fixed position by rotational slip in body 1.
As a preferred solution, protrusion 16 is located at this side that box body 1 is open, as shown in figure 12；Due to specification
After bending or bending to tubular, two end faces can be formed, when being put into box body, the two end faces one are located at box body bottom, and one
A to be located at box opening, convex block, which needs to be arranged in specification, to be located on this end face of 1 opening of box body, and when taking-up can
It plays a role.
The use of whole blood HIV detection devices includes the following steps：
(1) it opens the lid 2, takes out heparin tube 3；
(2) finger is punctured with blood taking needle 5,
(3) blood was collected for opening heparin tube lid 8；
(4) the buffer solution apparatus for placing 4 on box cover 2 is inserted into one end that heparin tube 3 is taken a blood sample, and runs plate and detects up to detection knot
Fruit.
Embodiment 2, with reference to attached drawing 16-27.
Box body 1 is in fan-shaped as shown in figure 16 with box cover 2 in the present embodiment.
The exploded view of the present embodiment whole blood HIV detection devices is as shown in figure 17.
As a preferred solution, blood taking needle 5 is mounted on the inside of the arcwall face of 1 linkage section 11 of box body, such as Figure 18 and 22
It is shown.
The schematic diagram that heparin tube 3 is taken out to detection box is as shown in figure 19.
As a preferred solution, it is detected in the present embodiment on box and is integrated with specification 15.
As a preferred solution, specification information is attached to the outer surface of box body 1, does not need positioning strip；By specification
15 are maintained at fixed position, avoid the loss of specification 15, do not interfere with the placement of other articles box body Nei.
As a preferred solution, a cambered surface of 1 outer surface of box body is posted respectively with two rectangle faces：Detection knot
Fruit illustrates that adhesive sticker, product information illustrate that adhesive sticker, product operation illustrate adhesive sticker, convenient for reading and operation instructions information.
As a preferred solution, the opening shape on buffer solution apparatus for placing 4, as shown in figure 24；Buffer solution is held
The opening shape of device 4 and the cross sectional shape of heparin tube 3 match, when heparin tube 3 is inserted into buffer solution apparatus for placing 4,
It outer surface can be with the opening close-fitting of buffer solution apparatus for placing 4；The two is interference fitted, and during use, heparin tube 3 is inserted into slow
Fliud flushing apparatus for placing 4 can form a sealing system as shown in figure 26, and buffer solution or blood sample is avoided to splash out.
The other embodiment of the present embodiment is same as Example 1.
Obviously, described embodiment is only a part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment should all belong to the scope of protection of the invention.
Embodiment 3, the application method of whole blood HIV detection devices.
The present embodiment provides a kind of detection method of whole blood HIV, this method is with the detection box of embodiment 1 or embodiment 2
Tool carries out HIV detections, and follows the steps below：
(1) detection box is opened, the box cover with buffer solution apparatus for placing is detached with box body；Before use, heparin tube, adopting
Blood needle and buffer solution apparatus for placing are encapsulated in detection box.
(2) heparin tube being placed in box body is taken out, exposes the blood taking needle for being placed in box body edge, heparin tube can be out of box body
It extracts, after heparin tube is extracted, the blood taking needle at box body edge is set and is just exposed, convenient for blood sampling.
(3) finger is pressed on blood taking needle surface, punctures finger skin to can extrude out blood；
(4) lid for removing blood sampling tube head is squeezed at the finger epidermis being punctured extremely with the capillary blood sampling head of heparin tube
It is drawn to the blood of sufficient amount, the end of heparin tube is equipped with capillary suction nozzle, and when there is blood outflow, capillary suction nozzle can draw blood
Liquid is placed in the working area in heparin tube, and pending buffer liquid runs plate after being added；
(5) after the completion of taking a blood sample, heparin tube is inserted into the buffer solution apparatus for placing in box cover, is pierced with the end of heparin tube
The encapsulated layer of broken buffer solution apparatus for placing makes capillary blood sampling head enter absorption buffer solution in buffer solution and carries out race plate；Due to slow
There are one opening, openings to be equipped with the sealing that can be punctured by hard object for fliud flushing apparatus for placing tool, as previously described in the embodiment, this
A sealing may be used aluminium foil and be made, and the blood sampling tube head extruded aluminium foil after blood sampling can break through aluminium foil, then heparin tube
Can from being stretched into opening in buffer solution apparatus for placing, then, capillary blood sampling head will automatic sucking buffer solution carry out race plate.
What needs to be explained here is that the outer shape of heparin tube and the shape of opening need to match, also, heparin tube is outer
Portion's sectional dimension slightly larger than opening size, in this way, after heparin tube stretches into, heparin tube can with opening close-fitting, to opening
It is sealed, prevents the buffer solution outflow for being mixed with sample, meanwhile, as soon as heparin tube and box cover are formed entirety, later not
It needs holding heparin tube, heparin tube can be moved by directly holding box cover, and further operating personnel reduce and sample connects
Tactile possibility.
(6) specification is taken out out of box body, or directly reads specification in box surface, will run hardened fruit and specification
On standard be compared, judge testing result.
(7) box cover with heparin tube is fastened on box body, so that heparin tube is closed in detection box, abandon, fastens
When, it is only necessary to box cover is caught, the tail portion of heparin tube is stretched into box body, then box cover and box body are fastened, completes encapsulation.
Claims (11)
1. whole blood HIV detection devices, characterized in that including detecting box, detect in box and be integrated with blood taking needle, heparin tube and buffer solution
Apparatus for placing, heparin tube are transparent tube bodies, are equipped with test paper in heparin tube, are held using preceding blood taking needle and heparin tube and buffer solution
Device does not contact, and heparin tube and buffer solution apparatus for placing combine outside detection box when use, and rear heparin tube and buffer solution is used to contain
The combination for putting device is enclosed in detection box.
2. whole blood HIV detection devices according to claim 1, characterized in that be integrated with specification within/on detection box.
3. whole blood HIV detection devices according to claim 1, characterized in that detection box includes box body and box cover, buffer solution
Apparatus for placing is fixed in box cover, and heparin tube is placed in box body, and blood taking needle is mounted on box body.
4. whole blood HIV detection devices according to claim 3, characterized in that one end of heparin tube is equipped with blood sampling head, blood sampling
Head is externally provided with heparin tube lid, and the other end of heparin tube is equipped with the first mounting base, the peace coordinated with the first mounting base is equipped in box body
Block is filled, the first mounting base can be set on mounting blocks.
5. whole blood HIV detection devices according to claim 4, characterized in that be equipped with the second mounting base, the second peace in box cover
It fills seat and is equipped with trepanning, buffer solution apparatus for placing is mounted in the trepanning.
6. whole blood HIV detection devices according to claim 5, characterized in that buffer solution apparatus for placing is equipped with opening, opens
Aluminium foil sealing is equipped at mouthful, aluminium foil sealing encapsulates buffer solution in it.
7. whole blood HIV detection devices according to claim 6, characterized in that the length in the one of direction of heparin tube lid
More than the length of buffer solution apparatus for placing opening in the same direction.
8. whole blood HIV detection devices according to claim 6, characterized in that the cross sectional shape and buffer solution of heparin tube are contained
The opening shape matching of device is put, when heparin tube stretches into buffer solution apparatus for placing, outer surface can be held with buffer solution
The opening close-fitting of device.
9. whole blood HIV detection devices according to claim 2, characterized in that specification can be bent, is bent or be rolled into
The shape consistent with inboard wall of cartridge is simultaneously placed between box body and heparin tube.
10. whole blood HIV detection devices according to claim 3, characterized in that blood sampling head is capillary suction nozzle, and heparin tube is in
It is flat, it takes a blood sample and is equipped with First Transition inclined-plane between head and heparin tube, sample working area is equipped in First Transition inclined-plane；Heparin tube
And first be equipped with the second intermediate incline between mounting base, the end face of the first mounting base is equipped with shirt rim.
11. the application method of whole blood HIV detection devices, this method uses the device described in any one of claim 1-10, and
It follows the steps below：
(1) detection box is opened, the box cover with buffer solution apparatus for placing is detached with box body；
(2) heparin tube being placed in box body is taken out, the blood taking needle for being placed in box body edge is exposed；
(3) finger is pressed on blood taking needle surface, punctures finger skin to can extrude out blood；
(4) lid for removing blood sampling tube head is squeezed with the capillary blood sampling head of heparin tube and is extremely drawn at the finger epidermis being punctured
To the blood of sufficient amount；
(5) after the completion of taking a blood sample, heparin tube is inserted into the buffer solution apparatus for placing in box cover, is punctured with the end of heparin tube slow
The encapsulated layer of fliud flushing apparatus for placing makes capillary blood sampling head enter absorption buffer solution in buffer solution and carries out race plate；
(6) hardened fruit will be run and standard is compared, judge testing result；
(7) box cover with heparin tube is fastened on box body, so that heparin tube is closed in detection box, abandons.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810403999.2A CN108742655A (en) | 2018-04-28 | 2018-04-28 | Whole blood HIV detection devices and application method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810403999.2A CN108742655A (en) | 2018-04-28 | 2018-04-28 | Whole blood HIV detection devices and application method |
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| Publication Number | Publication Date |
|---|---|
| CN108742655A true CN108742655A (en) | 2018-11-06 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810403999.2A Pending CN108742655A (en) | 2018-04-28 | 2018-04-28 | Whole blood HIV detection devices and application method |
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| CN111458492A (en) * | 2020-05-08 | 2020-07-28 | 山西医科大学 | POCT blood detection box |
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