CN201555848U - Detecting device - Google Patents

Abstract

The utility model provides a detecting device, which comprises a detecting element (102), a read device and an obstructing component, wherein the detecting element (102) comprises a sample area (1021) in contact with a liquid sample, and a detecting area (1022) for receiving the liquid sample from the sample area; the read device used for reading a detection result on the detection area comprises an electronic element component; and the obstructing component is used for obstructing the liquid sample in contact with the sample area to be in contact with the electronic component or be exposed outside the detection device. When the detecting device is in use, the liquid sample can be prevented from being in contact with the electronic component accidentally or being exposed outside the detecting device, at the same time, the stability and the operation safety of the detecting device are improved.

Description

Pick-up unit

Technical field

The utility model belongs to the diagnostic detection field, belongs to the field of detecting analyte in the sample especially, especially belongs to detect the metabolin that whether contains the drug abuse material in the sample or the quick diagnosis pick-up unit of women's gestation aspect.

Background technology

In recent years, pick-up unit is made the body fluid that is used for detecting the people in a large number, urine for example, the analyte in saliva or the blood, for example indicator substance of drug abuse or disease.Traditional like this pick-up unit need be collected in liquid sample to a container usually, inserts detecting element in the liquid then and then takes out and read test result on (with the naked eye see or read with machine) detecting element.Might allow the operator by sample contamination like this.Use this pick-up unit except being used by professional testing staff, do not had the people of professional experiences to use by some gradually, for example use in the family, this just need provide a kind of operation simpler, and testing result is pick-up unit more accurately.Utilize electronic technology to come direct read test result's device directly, simply to become more and more universal because obtain testing result.But, when carrying out test result with these electronic equipments when reading, because incorrect operation may allow and just flow on the electronic equipment at detected liquid sample, thereby the electronic component that damages on these equipment causes incorrect reading, even can not finish detection; In addition, when need do further affirmation chemical examination, usually need that whole detection device is transported to the another one place and chemically examine, in transportation, also may cause the leakage of liquid sample the sample in the pick-up unit.This just need provide a safer pick-up unit to satisfy these needs.

Summary of the invention

In order to satisfy these requirements, the utility model provides a kind of pick-up unit, comprising: a detecting element, and it comprises the sample areas of contact liq sample and reception surveyed area from the sample areas liquid sample; With a fetch equipment that is used to read testing result on the surveyed area, this equipment comprises electronic component; Wherein, this pick-up unit also comprises liquid sample contact electronic component that an obstruct contacts with sample areas or the barrier component that is leaked to the pick-up unit outside.Utilize this device when using this equipment, can not allow liquid sample contact electronic component unexpectedly or be leaked to the outside of pick-up unit, improved the stability and the processing safety of pick-up unit simultaneously.

More preferably in the embodiment, barrier component is between the sample areas and electronic component on the detecting element at some.Device can also comprise a test chamber, and barrier component is divided into test chamber the detection epicoele and detects cavity of resorption, and described part sample areas is positioned at and detects cavity of resorption, and electronic unit is positioned at and detects epicoele.More excellent, also comprise a ring-type cell body on the barrier component, an elastomeric element that is used for hermetic barrier parts and test chamber inner wall surface is set on the ring-type cell body.More excellent, barrier component also comprises an absorber element that is used to absorb from detecting the cavity of resorption liquid sample.More excellent, absorber element is positioned at a housing.In addition, absorber element also can be positioned at and detect epicoele.

Other preferred embodiment in, barrier component also comprises a through hole, the sample areas of detecting element is arranged in by this through hole and detects cavity of resorption.In some preferred modes, housing and barrier component can be connected as a single entity.Pick-up unit can also comprise a lid, and test chamber and lid are connected as a single entity.

In the concrete embodiment of other, this device also comprises a liquid sample transfer chamber, and an aperture film wherein is set between transfer chamber and test chamber; Wherein, when this pick-up unit is inserted in the liquid sample collecting chamber, the liquid sample in the collecting chamber enters in the liquid sample transfer chamber, but this liquid sample can not enter in the test chamber by described film; And wherein, when a piston is inserted in the liquid sample transfer chamber, this piston forces the partially liq sample in the transfer chamber to enter into test chamber by this porous membrane.More excellent, aperture is set to have surface tension of liquid, and when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by this aperture; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber can enter in the test chamber by described aperture.Better, lid, test chamber, transfer chamber and porous membrane are structure as a whole, and can be the mould of plastics single injection-molded.

In the other embodiment, described fetch equipment comprises: counting circuit, a kind of signal of chemically examining the amount of thing or chemically examining the accumulative speed of thing of response expression, if described signal surpasses presetting first threshold or is lower than the second default threshold value before chemical examination is not finished, then represent result of laboratory test, wherein, described second threshold value is less than first threshold.In addition, described fetch equipment can also comprise: at least one light source, and it can be luminous, and these light incide in the district that separates on two or more spaces on the described detecting element at least one; At least one photodetector arranges that its position makes it possible to detect the light that each district from two described districts spreads out of, and generation is illustrated in the signal that has or do not exist liquid sample in the respective area; And a counting circuit, respond described signal and calculate liquid sample along the flow velocity that flows between two districts on the described detecting element; Judge whether the flow velocity that is calculated can accepted outside the predetermined restriction.Fetch equipment can also comprise: first, second and the 3rd light source, and it can send corresponding first, second and the 3rd light of separate areas spatially that is used to shine on the described detecting element; With first and second photodetectors, wherein said first photodetector is used for detecting from each light that sends in described first and second zones and described second photodetector and is used for detecting each light that sends from the described second and the 3rd zone.In addition, can also comprise an electrode that is used to judge that liquid sample is whether enough on the fetch equipment.

Beneficial effect

The utility model makes and detects sample and settle at one go, can not allow liquid sample contact electronic component unexpectedly in this equipment of use or is leaked to the outside of pick-up unit, has improved the stability and the processing safety of pick-up unit simultaneously.

Description of drawings

Fig. 1 is the sub-perspective view of some specific embodiments of device of the present utility model;

Fig. 2 is the structure exploded perspective view of device shown in Figure 1;

Fig. 3 is the perspective view of gathering-device;

Fig. 4 is the assembling profile synoptic diagram of device shown in Figure 1;

Fig. 5 is the assembling square section synoptic diagram of device shown in Figure 1;

Fig. 6 is the structure exploded perspective view of pick-up unit in the object lesson of the present utility model;

Fig. 7 is the assembling perspective view of pick-up unit shown in Figure 6;

Fig. 8 A is the profile schematic perspective view of pick-up unit shown in Figure 7;

Fig. 8 B is A part structure for amplifying synoptic diagram on Fig. 8 A;

Fig. 9 A is the square section schematic perspective view of pick-up unit shown in Figure 7;

Fig. 9 B is B part structure for amplifying synoptic diagram on Fig. 9 A.

Description of reference numerals:

Detection device component 10, pick-up unit 101, test chamber 14, transfer chamber 15, lid 19, gathering-device 72, collecting chamber 721, collecting chamber opening 723, piston 722, collecting chamber bottom 724, test chamber opening 142, test chamber interior walls 141, detect epicoele 143, detect cavity of resorption 144, plastic tab 16, elastic sealing ring 13, transfer chamber opening 204, detecting element 102, the sample areas 1021 of detecting element, the surveyed area 1022 of detecting element, absorber element 11, circuit board 103, tabula disconnected 109, lower wall 129, lower wall opening 120, lower wall through hole 124, ring-type cell body 131, detecting element supporting construction 123,122, left side wall 128, right side wall 127, housing 12, base plate 125, pin hole 121, latch 1211, display screen 1011, bayonet arrangement 119, electrode 107, semisphere barrier element 108, syndeton 104, slit 456.

Embodiment

In the following detailed description, the explanation of accompanying drawing and corresponding character only is the mode that illustrates that by way of example the utility model can actable specific concrete scheme.We do not get rid of the utility model can also be in any other embodiment in the utility model claim scope.

The utility model provides a kind of pick-up unit.This device comprises: a detecting element 102, and it comprises the sample areas 1021 of contact liq sample and reception surveyed area 1022 from the liquid sample of sample areas; With a fetch equipment that is used to read testing result on the surveyed area, this equipment comprises electronic component; This pick-up unit also comprises liquid sample contact electronic component that an obstruct contacts with sample areas or the barrier component that is leaked to the pick-up unit outside.

In a concrete example, as shown in Figure 6, a barrier component part is positioned on the fetch equipment, and another part can individualism, and these two parts cooperatively interact and form complete barrier component.For example, the part barrier component that is positioned on the fetch equipment can be that tabula breaks 109, and another part barrier component can be a partition 129 that has opening 120, and tabula disconnected 109 reaches hydraulic seal with form 119 cooperations of opening 124 bayonet sockets.The mode that cooperates has a lot, for example allows tabula disconnected corresponding with opening 120 with size and shape.More excellent, on barrier component, comprise a through hole 124, the size of through hole and the square section of detecting element coupling, the sample areas of detecting element is passed through hole 124, barrier component is divided into two parts to detecting element like this, one end of sample areas is used for the contact liq sample, and an end of surveyed area is used for being read equipment and reads testing result and be presented on the display screen 1011.When using this pick-up unit, when the liquid sample zone on the detecting element contacts with liquid sample, owing to there is such barrier component, can avoids liquid sample to contact electronic component on the fetch equipment like this " accident ", thereby damage fetch equipment.Here said " accident " be meant in any operating process or the process of pick-up unit after finishing detection in, because factor artificial or the objective external world causes that liquid sample may contact the electronic component on the fetch equipment, or be leaked to pick-up unit outer any situation or condition.For example, when pick-up unit being inserted into when allowing the sample areas contact liq sample of detecting element in the liquid sample, may being splashed to the electronic component on the fetch equipment because liquid rocks, thereby damaging electronic component; This rock may owing to insert fast unconsciously detecting element in liquid sample or the operator deliberately cause whole detection can not be gone on.

Fetch equipment comprises the circuit board 103 that contains electronic component and cooperates electronic component to read on the detecting element 102 syndeton 104 of test result on the surveyed area 1022.Electronic component on the fetch equipment can comprise: counting circuit, a kind of signal of chemically examining the amount of thing or chemically examining the accumulative speed of thing of response expression, if described signal surpasses presetting first threshold or is lower than the second default threshold value before chemical examination is not finished, then represent result of laboratory test, wherein, described second threshold value is less than first threshold.Electronic component on the fetch equipment can also comprise at least one light source, and it can be luminous, and these light incide in the district that separates on two or more spaces on the described detecting element at least one; At least one photodetector arranges that its position makes it possible to detect the light that each district from two described districts spreads out of, and generation is illustrated in the signal that has or do not exist liquid sample in the respective area; And a counting circuit, respond described signal and calculate liquid sample along the flow velocity that flows between two districts on the described detecting element; Judge whether the flow velocity that is calculated can accepted outside the predetermined restriction.Electronic component on the fetch equipment also can comprise: first, second and the 3rd light source, and it can send corresponding first, second and the 3rd light of separate areas spatially that is used to shine on the described detecting element; With first and second photodetectors, wherein said first photodetector is used for detecting from each light that sends in described first and second zones and described second photodetector and is used for detecting each light that sends from the described second and the 3rd zone.Mode that these are concrete such as Chinese utility application, application number 200410045273.4,200410045275.3,200410063910.0 in disclosed all relevant fetch equipments, fetch equipment reads on detection (test) element and to detect (test or chemical examination) result, and how fetch equipment is fixed on all embodiments on the reagent strip by syndeton and all can be used to and be used as a concrete embodiment in the utility model.

In the more excellent concrete embodiment of other, can also be set up a ring-type cell body 131 on the barrier component, this cell body is near the sample areas of detecting element, disconnected from tabula to lower process, an elastic sealing ring 13 is set on cell body, and when pick-up unit being inserted in the test chamber 14, barrier component is divided into up and down two independently chambeies to test chamber, elastic sealing ring contacts with the inwall 141 of test chamber better by barrier component, thereby reaches better separation effect.Elastic sealing ring 13 can be that those non-water-absorbing materials are formed, for example rubber, flexible plastic etc.More excellent, a housing 12 is set on barrier component, it comprises base plate 125, is positioned at the sidewall 127,128 and the lower wall 129 of base plate the right and left, they surround a groove jointly, and an element 11 that absorbs liquid is set in groove.Because detecting element is arranged in test chamber by the through hole on the barrier component 124, always there are some slits 456 at detecting element and through hole, liquid sample in test chamber might by " accident " and enter in the groove by these slits, the absorber element that is arranged on like this in the groove can absorb these liquid samples fast, can prevent the electronic component on these liquid sample contact arrangements effectively.In addition, after finishing detection, think that test result need do further affirmation analysis, for example use the general instrument of liquid phase matter, need be transferred to analytic centre to the liquid sample in pick-up unit and the test chamber together and analyze, in this time, pick-up unit may be shaken in transportation or tilt, the liquid sample that is arranged in test chamber like this may enter groove by opening 120, through hole 124 or slit 456, even may be leaked to outside the pick-up unit through electronic component.Like this, the barrier component that is provided with can prevent liquid sample contact electronic component, simultaneously the absorber element of She Zhiing can be better enter into when liquid sample detect epicoele after the fast Absorption liquid sample, prevent from that liquid sample from damaging electronic component or being leaked to test chamber to cause pollution outward to environment.

Pick-up unit can also comprise liquid sample transfer chamber 15; An and porous membrane 16 between sample transfer chamber and test chamber, when this pick-up unit being inserted in the liquid sample collecting chamber 72, liquid sample in the collecting chamber enters in the liquid sample transfer chamber, but this liquid sample can not enter in the test chamber 14 by film 16; And wherein, when a piston 722 is inserted in the liquid sample transfer chamber 15, this piston forces the partially liq sample in the transfer chamber to enter into test chamber 14 by this porous membrane 16.

Showed an embodiment of the present utility model as Fig. 1-5.Now describe in detail.Collecting chamber 72, one end openings are used for admitting or accommodating liquid sample, a piston 722 to be positioned at the bottom of collecting chamber and to upper process.Pick-up unit 10 comprises a test chamber 14, this test chamber can be held detecting element and the liquid sample of accepting from transfer chamber, with a liquid sample transfer chamber 15, a plastic tab that has several apertures is set between transfer chamber and test chamber, test chamber and atmosphere communicate.And size or shape that aperture is set allow aperture have certain surface tension of liquid, for example allow the interior diameter of aperture be 1.0 millimeters.Simultaneously, test chamber, the plastic tab that has aperture and transfer chamber are the plastics once injection moulding; Collecting chamber also is the plastics once injection moulding with the piston that is positioned at the bottom, chamber.When in use, after having collected the certain amount of fluid sample in the collecting chamber, a large amount of liquid samples is collected in the collecting chamber, then detection part is inserted in the collecting chamber, in insertion with near in the process of piston, partially liq sample in the collecting chamber enters in the transfer chamber 15 by transfer chamber opening 204, and the gas in the transfer chamber is rejected in the test chamber by aperture.Along with further being moved downward of transfer chamber, the gas that is arranged in transfer chamber has been arranged, liquid sample almost completely is full of whole transfer chamber, formed surface tension at the aperture place this moment, even the liquid surface in the transfer chamber is lower than the liquid level in the collecting chamber, the liquid in the transfer chamber can not enter in the test chamber by aperture.Along with further being moved downward of transfer chamber, piston is inserted in the transfer chamber, forces liquid sample in the transfer chamber to enter in the test chamber by aperture and contacts with the sample areas of detecting element.

Except above concrete mode, the aperture film with this character can be selected arbitrarily, for example selects those films with micro hole, cellulose nitrate film for example, nylon film or filter paper, glass fibre or the like.Certainly can also be plastic sheet with micro-aperture.In some preferred embodiments, test chamber 14 and transfer chamber 15 public faces, 16 on Fig. 4 for example, this face is separated test chamber and transfer chamber, on this face 16 some apertures is set, these aperture communication with detection chamber and transfer chamber.In a preferred mode, pick-up unit is an once injection moulding, and public isolation surface 16 is a plastic sheet, and thickness is approximately 1.5 millimeters, and some apertures are set on plastic sheet.In the other examples of implementation, the surface tension of liquid that aperture had on the film is set, liquid surface can come to be provided with arbitrarily as required, for example changes the internal diameter size of aperture, the perforate degree of depth of aperture, the shape of aperture or these combination of features.The quantity of aperture can be 2 for one or more, 3, and 4,5 or more; The diameter of aperture can be the 1-5 millimeter, can be 0.1,0.2,0.3,0.4,0.5,0.8,0.9,1,2,3,4,5 or 6 millimeter; The shape of aperture can be right cylinder shape or taper or other shapes; The thickness of aperture is the 0.1-10 millimeter, can be 0.1,0.2,0.5,1.0,1,3,5,7,9,2,4 or 6 millimeters etc.In specific embodiment, aperture is the cylinder bodily form, and the interior diameter of aperture is 0.5 millimeter, is 1.5 millimeters deeply, also can be tapered aperture or back taper aperture.Change the size of these apertures, the mode of the shape or the degree of depth has a variety of, the film of micro-aperture that can be by selecting different materials, filter paper, glass fibre etc.Also have a variety of test chamber and the separated mode of transfer chamber, for example passed through the once injection moulding hollow circular cylinder before this, his both ends open, in the right cylinder position intermediate film that one deck has micro hole is set then, for example a layer thickness is 1.5 millimeters a filter paper, this layer film is separated into two chambeies to this right cylinder, test chamber 15 and transfer chamber 14.

In some cases, because the continuity and the transience of sampling operation, the liquid sample that comes out from aperture sometimes is " injection " shape and enters in the test chamber.In order to prevent that these liquid samples are ejected on other elements that are positioned at test chamber, a protecting component is set above aperture, this element can be ejected on other elements by barrier liquid, does not influence liquid sample again simultaneously and contacts with detecting element.For example shown in Figure 5, above aperture, be provided with one and fall " U " shape structure 108, this structure can allow the liquid sample that is " injection " shape enter in the test chamber and contact and can not contact by her element with it with detecting element.When particularly containing electronic component in the test chamber, utilize protecting component can allow electronic component can not destroy some functions more safely because of the contact liq sample.

Now 1-10 gives detailed explanation specific embodiment of the present utility model in conjunction with the accompanying drawings.Fig. 1-5 provides a test section, comprises that lid 19 is used for covering on the opening 723 of collecting chamber 721.Comprise on the lid that a test chamber 14 that is roughly rectangular parallelepiped is used for acceptable solution sample body and hold detecting element.Test chamber 14 1 end openings 142 and the other end are provided with a plastic tab that has 4 apertures, and the thickness of thin slice is 1.2 millimeters, and the diameter of each aperture is 0.4 millimeter.Also comprise a liquid sample transfer chamber 15 on lid, its end is connected with plastic tab, other end opening.Lid, sample transfer chamber, test chamber and the plastic tab that has an aperture are by an injection molding.One end opening of collecting chamber, the other end seals as bottom 724, and a projection is set on the bottom, with the piston 722 of transfer chamber size coupling.Collecting chamber and piston are connected as a single entity and by once injection moulding.A pick-up unit 101 is set in test chamber, and pick-up unit comprises a detecting element 102 and read test result's fetch equipment.Detecting element is the immunoreagent bar, comprises the sample areas 1021 and the surveyed area 1022 that receive liquid sample; Fetch equipment comprises the link 104 of circuit board 103 and fixed test element, above link 104, install circuit board, detecting element 12 is installed in the corresponding position below link 104, allow the electronic component of the read test result on surveyed area 1022 and the circuit board of detecting element corresponding simultaneously, for example light emitting diode and photoelectric detector.End at link stretches out, and forms a horizontal partition 109 vertical with link, laterally cuts off with link wide.Laterally partition further extends to form a hemispheric barrier element 108, can stop the liquid sample that ejects from the plastics aperture.Circuit board 103, test-strips 102, link 104 can be assembled as a whole, as shown in figure 13.The global facility of assembling can be positioned on the housing 12, comprise a base plate 125 on the housing, both sides are provided with a sidewall 127 respectively on base plate about 125,128, with the lower end sidewall 129 is set, groove of base plate and sidewall besieged city, the groove in besieged city size and shape and test chamber coupling simultaneously, can allow test chamber just can hold whole housing 12 down, shown in Fig. 3 and 1.In groove, place the element 11 that absorbs liquid, for example a sponge or a filter paper.Simultaneously, on lower wall 129, open a gap 120, can cooperate formation to closely cooperate with the tabula on the link 104 is disconnected, shown in Fig. 6 and 7.In addition, open a through hole 124 on lower wall, the size match of its size dimension and reagent strip allows the sample areas of reagent strip enter in the test chamber by this hole 124 and contacts with liquid sample.An annular groove 131 also is set on lower wall in addition, an elastic sealing ring 13 is set on annular groove 1.When housing and be installed in pick-up unit on the housing put into test chamber after, sealing ring 13 allows lower wall 129 cooperate with the interior walls 141 of test chamber closely, lower wall on the housing and sealing ring are divided into test chamber and detect epicoele 143 and detect cavity of resorption 144 like this, as Fig. 4 and shown in Figure 3.In order to allow reagent strip stationkeeping and allow circuit board 103, link 104 stationkeeping, the structure 122,123 of a pin hole 121 and support fixation reagent strip is set on base plate 125.A latch 102 is set on link 104 like this, in the time of assembling, allow latch be inserted on the pin hole, as shown in Figures 9 and 10, allow housing and electronic component like this, reagent strip by link be connected to one whole, allow positions of electronic parts relative fixed on reagent strip and the circuit board, increased the stability of whole checkout equipment like this.

Be structure as a whole with lid 19 essence after the pick-up unit 101 that has housing is inserted into test chamber, shown in Fig. 3 and 4.The person obtains testing result to allow the screen 101 of display result expose the handled easily.When in use, cover cap is incorporated on the opening of collecting chamber and rotation, liquid sample in the collecting chamber flows in the transfer chamber 15 like this, owing to be provided with the size of aperture, aperture has certain surface tension, even transfer chamber is lower than the liquid level of collecting chamber, the liquid of transfer chamber can not enter in the test chamber by aperture yet, and the air in the transfer chamber is discharged to outside the transfer chamber by aperture simultaneously.Along with being further rotated of lid, the opening 204 of transfer chamber by piston seal, stops more liquid sample to enter in the transfer chamber near piston.Along with being further rotated again of lid, piston is inserted in the transfer chamber, and the liquid sample in the transfer chamber is forced through aperture and enters into and detect cavity of resorption and contact with sample areas on the reagent strip, and liquid sample enters surveyed area because of capillary action.Simultaneously, in the process of rotation, be arranged on the horizontal partition that detects on the cavity of resorption and can stop liquid sample to enter the electronic component that detection epicoele destruction is positioned at epicoele.The carrying out of surveyed area chemical reaction, the electronic component on the circuit board draws test result by calculating and operation, and is presented on the screen.Usually, in some cases, because operator's individual difference, cover lid to collecting chamber and the speed difference of rotating lid, the speed that liquid enters test chamber also differs just the same.When using, because the fast moving of piston in transfer chamber detects in the cavity of resorption thereby may cause liquid type to be injected into like " fountain " shape than fast speeds rotation lid.Tabula disconnected below, the top that faces aperture is provided with hemispheric stop member 108, similar " fountain " shape liquid contact semisphere detects in the cavity of resorption thereby entered by hemispheric inside surface reflection, contacts with sample areas.

After finishing detection, may need further to be transported to the chemical examination center confirms to analyze, test is positioned at the liquid sample that detects cavity of resorption may enter the detection epicoele by the opening 124 or the slit 456 at test-strips place, after this unexpected situation takes place, be positioned at the absorber element of groove, sponge for example, face can the fast Absorption liquid sample, avoid liquid sample to be leaked to outside the test chamber, for example be leaked on the lid.

In another embodiment, detect in the cavity of resorption in order to guarantee that enough this samples of liquid enter, pair of electrodes 107 is set on circuit board, electrode can enter into by the opening on the lower wall and detect in the cavity of resorption.When sufficient liquid was arranged in the test chamber, electrode was by fluid connection, and the electronic component on the energizing circuit plate is started working, and the surveyed area on the test-strips is carried out test result read and calculate.On the contrary, if the liquid sample in the test chamber is inadequate, electrode can not be connected, when waiting for that an end is after the time, if electrode still is not connected, then system provides a negative result, and this negative decision energizing circuit does not carry out any work, and on display screen display message, the result of indicating liquid deficiency.

Detecting element can be some laboratory reagent bars, for example can be the lateral-flow assays reagent strip of any routine, as disclosed reagent strip among EP291194 or the US6352862.Reagent strip preferably includes porous infiltration carrier, and this carrier comprises the not particular combination reagent of tape label of a label particular combination reagent and one.Particularly, EP291194 discloses a kind of immunoassay reagent bar, comprising: the carrier of a porous infiltration, and this carrier comprises and is used for a kind of particular combination reagent of chemically examining the particulate label of thing, and under dampness, this reagent can move freely; With a kind of particular combination reagent that is used for the not tape label of same chemical examination thing, this immobilization of reagents is in the detection zone or test section in the specific adhesive agent downstream of described not tape label.Suspect that the liquid sample that contains described chemical examination thing is applied to the carrier of described porous infiltration, should chemically examine the particular combination reagent effect of thing and described particulate label thereon, form a kind of complex of chemically examining thing-combination.Described particulate label is coloured, normally golden or dyeing condensate, for example, latex or poly-inferior peace fat.Described complex moves into detection zone subsequently, constitutes another mesocomplex at the particular combination reagent of detection zone and described fixing not tape label, and what make described chemical examination thing exists scope detected or observe.

" sample " refer to need chemical examination whether to exist and (or) analyze any material of analyte concentration, maybe need to determine whether one or more samples exist and (or) material of the analyte of quantity, maybe need to carry out the material of qualitative evaluation.Sample can be liquid sample, for example liquid sample.Liquid sample comprises body fluid, such as blood, serum, blood plasma, saliva, urine, tears, seminal fluid and marrow; Liquid sample also can be a water sample, such as seawater, river, river etc., perhaps from domestic water, municipal water use or service water resource, runoff water or sewage; Sample can be a food sample, such as milk and wine.Mucus, semisolid or solid sample can be used for making liquid, eluate, suspending liquid or leachate equal samples.For example, throat or genitals sample may be dipped in and make sample in the liquid.Sample can comprise potpourri or any relevant potpourri of liquid, solid and gas, such as the cell suspending liquid in dilution or the solution.Sample comprises biological substance, such as cell, microorganism, organelle and biochemical complexes.Liquid sample can be from producing such as solid, semisolid or high-viscosity materials such as soil, ight soil, tissue, organ, biological fluid or other occurring in nature non-liquid samples.For example, these solids or semi-solid samples can be mixed with the suitable solution of dilution one class.Sample can be macerated, freezing and thaw, perhaps other extracting method form liquid samples.Remaining particulate material can use traditional method such as filtration or precipitation to remove.

Analyte can be " drug abuse " (DOA) or other have interested material in the sample." drug abuse " (DOA) is meant that the non-medical destination uses medicine (playing the paralysis nerve usually).Abuse these medicines and can cause body ﹠ mind to suffer damage, produce dependence, habit-forming and/or dead.The example of drug abuse comprises cocaine; Amphetamine (for example, black beauty, white amphetamine tablet, dextroamphetamine, dexie, Beans); Crystal methamphetamine (crank, meth, crystal, speed); Barbiturate (as Valium, Roche Pharmaceuticals, Nutley, NewJersey); Sedative (paramedicines of promptly sleeping); Lysergic acid diethylamide (LSD); Inhibitor (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); Hog (PCP); Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); Opiate (being morphine, opium, codeine, heroin, the hydroxyl dihydrocodeinone); Anxiolytic and hypnotic sedative agent, anxiolytic is that a class is mainly used in anxiety reduction, nervous, frightened, set the mind at rest, have the medicine of hypnosis sedation concurrently, comprise Benzodiazepines (benzodiazepines, BZ), atypia BZ class, merge phenodiazine NB23C class, the tall and erect class of benzene nitrogen, the part class of BZ acceptor, open loop BZ class, diphenylmethane derivatives, the piperazine carboxylic acid salt, the piperidine carboxylic acid salt, Kui azoles quinoline ketone, thiazine and thiazole, other heterocyclic, imidazole type calmness/anodyne, propanediol derivative-carbamates, fatty compound, anthracene derivative etc.Use this device also can be used to detect and belong to medical usage but the detection of overdose easily, as tricyclic antidepressant (imipramine or analog) and Paracetamol etc.Can resolve into different small-molecule substances after these medicines are absorbed by the body, these small-molecule substances are present in the body fluid such as blood, urine, saliva, sweat or there is above-mentioned small-molecule substance in part body fluid.

Claims (16)

1. pick-up unit comprises:

A detecting element, it comprises the sample areas of contact liq sample and reception surveyed area from the sample areas liquid sample; With a fetch equipment that is used to read testing result on the surveyed area, this equipment comprises electronic component; It is characterized in that this pick-up unit also comprises liquid sample contact electronic component that an obstruct contacts with sample areas or the barrier component that is leaked to the pick-up unit outside.

2. device according to claim 1 is characterized in that, barrier component is between the sample areas and electronic component on the detecting element.

3. device according to claim 1 is characterized in that, this device also comprises a test chamber, and barrier component is divided into test chamber the detection epicoele and detects cavity of resorption, and described part sample areas is positioned at and detects cavity of resorption, and electronic unit is positioned at and detects epicoele.

4. device according to claim 3 is characterized in that, described barrier component also comprises an absorber element that is used to absorb from detecting the cavity of resorption liquid sample.

5. device according to claim 3 is characterized in that, this device also comprises a groove, and absorber element is positioned at this groove.

6. device according to claim 4 is characterized in that described absorber element is positioned at the detection epicoele.

7. device according to claim 5 is characterized in that described groove and barrier component are connected as a single entity.

8. device according to claim 3 is characterized in that, also comprises a ring-type cell body on the barrier component, and an elastic sealing element that is used for hermetic barrier parts and test chamber inner wall surface is set on the ring-type cell body.

9. device according to claim 3 is characterized in that, this pick-up unit also comprises a lid, and test chamber and lid are connected as a single entity.

10. device according to claim 3 is characterized in that, described barrier component comprises a through hole, and the sample areas of detecting element is positioned at the detection cavity of resorption by this through hole.

11. device according to claim 3 is characterized in that,, this device also comprises a liquid sample transfer chamber, and an aperture film wherein is set between transfer chamber and test chamber; Wherein, when this pick-up unit is inserted in the liquid sample collecting chamber, the liquid sample in the collecting chamber enters in the liquid sample transfer chamber, but this liquid sample can not enter in the test chamber by described aperture film; And wherein, when a piston is inserted in the liquid sample transfer chamber, this piston forces the partially liq sample in the transfer chamber to enter into test chamber by this porous membrane.

12. device according to claim 11, it is characterized in that, described aperture is set to have surface tension of liquid, when the pressure differential of described transfer chamber and test chamber was less than or equal to the set surface tension of liquid of this aperture, the liquid sample in the transfer chamber can not enter test chamber by this aperture; When the pressure differential of described transfer chamber and test chamber greater than the set surface tension of liquid of this aperture the time, the liquid in the transfer chamber can enter in the test chamber by described aperture.

13. device according to claim 1, it is characterized in that, described fetch equipment comprises: counting circuit, a kind of signal of chemically examining the amount of thing or chemically examining the accumulative speed of thing of response expression, if described signal surpasses presetting first threshold or is lower than the second default threshold value before chemical examination is not finished, then represent result of laboratory test, wherein, described second threshold value is less than first threshold.

14. device according to claim 1 is characterized in that, described fetch equipment comprises: at least one light source, and it can be luminous, and these light incide in the district that separates on two or more spaces on the described detecting element at least one; At least one photodetector arranges that its position makes it possible to detect the light that each district from two described districts spreads out of, and generation is illustrated in the signal that has or do not exist liquid sample in the respective area; And a counting circuit, respond described signal and calculate liquid sample along the flow velocity that flows between two districts on the described detecting element; Judge whether the flow velocity that is calculated can accepted outside the predetermined restriction.

15. device according to claim 1 is characterized in that, described fetch equipment comprises: first, second and the 3rd light source, and it can send corresponding first, second and the 3rd light of separate areas spatially that is used to shine on the described detecting element; With first and second photodetectors, wherein said first photodetector is used for detecting from each light that sends in described first and second zones and described second photodetector and is used for detecting each light that sends from the described second and the 3rd zone.

16. device according to claim 1 is characterized in that, also comprises an electrode that is used to judge that liquid sample is whether enough on described fetch equipment.

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