JP2017194324A - Saliva preservation kit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To ensure the airtightness of a container when or after a preservation liquid and saliva in a saliva preservation kit are mixed together.SOLUTION: A saliva preservation kit 1 is configured so that a sealing part 61 enters into a space B between the outer periphery surface of a lid body 31 and the inner periphery surface of a preservation liquid container 12 before a pressing part 60 presses the lid part 31 until the lid part is broken so as to seal the space between the outer periphery surface of a collapse member 32 and the inner periphery surface of the preservation liquid container 12, when the collapse member 32 is pushed by a saliva collecting container 10 and is moved toward the lid part 31.SELECTED DRAWING: Figure 12

Description

  The present invention relates to a saliva storage kit.

  In recent years, for example, a DNA test for examining a genetic tendency of a disease or a constitution has been performed. In this DNA test, there is a method in which the subject's saliva is collected, and for example, the subject purchases a saliva storage kit, and the saliva is collected and stored in the saliva storage kit. Is sent to a DNA testing organization.

  The instrument having the function of the saliva preservation kit as described above has, for example, a lid having an internal chamber for containing the preservation liquid and a tube for containing the sample body fluid, and the lid is fitted into the tube containing the sample body fluid. There is a body fluid sample collection device in which the internal chamber in the lid is opened and the preservation liquid in the internal chamber is mixed with the sample body fluid in the tube (see Patent Document 1).

JP 2014-527615 A

  However, in the body fluid sample collection device as described above, the airtightness of the container when the preservation solution is mixed with the body fluid or after the mixture is dependent only on the lid and tube meshing mechanism, it may not be sufficiently secured. is there.

  If the airtightness of the container is not sufficient when the preservation solution and body fluid are mixed or after mixing, the preservation solution may leak or evaporate from the container, and the preservation solution may decrease or disappear before DNA testing is performed. The saliva is not properly stored and the DNA test cannot be performed properly.

  The present application has been made in view of such a point, and an object of the present application is to provide a saliva storage kit that can sufficiently ensure the airtightness of the container when the storage liquid and the saliva are mixed or after mixing.

  As a result of intensive studies, the present inventors have provided a crushing member for crushing the bottom of the storage liquid storage chamber in the storage liquid container in the saliva storage kit, and the crushing member is pushed and sealed by the saliva collection container. When the crushing member presses the capped bottom surface and crushes when moved to the bottom surface side, the sealing portion enters the concave portion of the capped bottom surface, and the outer peripheral surface of the crushing member and the storage liquid storage container In the configuration for sealing between the inner peripheral surfaces, or in the saliva storage kit, the inside of the storage liquid storage container is provided with a lid for sealing the storage liquid storage chamber and a crushing member for crushing the lid, When the crushing member is pushed by the saliva collection container and moves to the lid body, the sealing portion presses the lid body and crushes the sealing portion before the outer peripheral surface of the lid body and the storage liquid container The crushing member enters the gap between the inner peripheral surface of the member By adopting a structure for sealing an outer peripheral surface and between the inner peripheral surface of the storage liquid container, it can solve the above problems, and have completed the present invention.

That is, the present invention includes the following aspects.
(1) A saliva storage kit, comprising: a saliva collection container having an opening on an upper surface; and a storage liquid storage container having an opening on a lower surface; and an upper portion of the saliva collection container having an upper surface opening. The storage liquid container can be fitted into the storage liquid storage container from the bottom opening, and the storage liquid storage container is formed with a storage liquid storage chamber having an upper surface that is opened and closed by a lid and a sealed bottom surface that is sealed. A crushing member for allowing the storage liquid to flow out of the storage liquid storage chamber by crushing the bottom surface of the storage and being movable to the sealed bottom surface side by pressing from below with the saliva collection container. The crushing member protrudes toward the sealed bottom surface and presses the sealed bottom surface, and an annular sealing portion is disposed around the pressed portion and protrudes toward the sealed bottom surface. , Stored outflow from the storage solution storage chamber A liquid passage port through which the liquid passes to the saliva collection container side, and an outer periphery of the sealed bottom surface is provided with a concave portion into which the sealing portion enters, and the crushing member is formed by the saliva collection container. When pressed and moved to the sealed bottom surface side, the sealing portion enters the recessed strip portion before the pressing portion presses and crushes the sealed bottom surface, and the outer peripheral surface of the crushing member and the storage solution A saliva storage kit configured to seal between the inner peripheral surface of the container.
(2) A saliva storage kit, comprising: a saliva collection container having an opening on an upper surface; and a storage liquid storage container having an opening on a lower surface; and an upper portion of the saliva collection container having an upper surface opening. The storage liquid storage container can be fitted from the lower surface opening, and the storage liquid storage container is formed with a storage liquid storage chamber having an outlet on the lower surface of the storage liquid storage container. On the lower side, a lid body that seals the outflow port, and can be moved to the lid body side by pressing from below with the saliva collection container. A crushing member for causing the crushing member to flow out, and the crushing member is disposed around the pressing part, a pressing part for projecting toward the lid body and pressing the lid body, An annular sealing portion projecting toward the lid body along the peripheral surface, and the front A liquid passage port through which the preservation solution flowing out from the outlet passes to the saliva collection container side, and a gap is provided between the outer peripheral surface of the lid and the inner peripheral surface of the preservation solution storage container, When the crushing member is pushed by the saliva collection container and moves to the lid side, the sealing portion and the outer peripheral surface of the lid body before the pressing portion presses and crushes the lid body A saliva preservation kit configured to enter the gap between the inner peripheral surface of the storage liquid storage container and seal between the outer peripheral surface of the crushing member and the inner peripheral surface of the storage liquid storage container.
(3) The lid has an annular flange portion having a larger diameter than the outflow port of the storage liquid storage chamber and is formed in the storage liquid storage container and has a step larger in diameter than the outflow port. The saliva storage kit according to (2), wherein the kit is fitted into a portion, and the flange portion is ultrasonically welded to the stepped portion in an annular shape.
(4) The saliva storage kit according to (2) or (3), wherein an annular notch is formed on a surface of the lid that is pressed by the pressing portion.
(5) The saliva preservation kit according to any one of (1) to (4), wherein the sealing part protrudes toward the preservation liquid storage chamber side from the tip of the pressing part.
(6) The pressing portion includes a plurality of pins, and the liquid passing port has a tapered surface whose diameter gradually increases toward the storage liquid storage chamber side on the opening surface of the storage liquid storage chamber side. The saliva storage kit according to any one of (1) to (5), wherein the pin is erected on the tapered surface.
(7) Any one of (1) to (6), further including a locking mechanism that locks the crushing member with respect to the storage liquid storage container at a position where the pressing portion collapses the storage liquid storage chamber. Saliva preservation kit as described in 2.
(8) (1) to (7) further including a locking mechanism that locks the crushing member with respect to the storage liquid container at a position before the crushing member moves to the storage liquid storage chamber side. The saliva preservation kit according to any one of the above.
(9) The crushing member has an abutting portion with which an upper end portion of the saliva collecting container abuts when an upper part of the saliva collecting container is fitted into the storage liquid storage container, and the crushing member Is configured to move to the storage liquid storage chamber side by being further inserted into the saliva collection container with the upper end of the saliva collection container in contact with the contact portion. The saliva preservation kit according to any one of (1) to (8).
(10) A gap into which the upper end portion of the saliva collection container is fitted is formed between the lower outer peripheral surface of the crushing member and the inner peripheral surface of the preservation liquid storage container, and the bottom of the gap is formed. The saliva preservation kit according to (9), wherein the contact portion is formed.
(11) The saliva preservation kit according to any one of (1) to (10), further including a detachable funnel at an upper portion of the saliva collection container.
(12) The saliva storage kit according to any one of (1) to (11), wherein a protruding portion that protrudes outward is formed on an outer peripheral surface of the storage solution container.

  According to the present invention, when the preservation solution and saliva are mixed and the airtightness of the container after mixing can be sufficiently ensured, leakage and volatilization of the preservation solution are suppressed, and the examination using the saliva can be appropriately performed. it can.

It is a perspective view which shows an example of the saliva preservation kit in 1st Embodiment. It is sectional drawing of the container for saliva collection. It is sectional drawing of the container for saliva collection which attached the funnel. It is an exploded view of a preservation | save liquid storage container. It is sectional drawing of a preservation | save liquid storage container. It is a top view of a lid. It is a top view of a crushing member. It is a perspective view when attaching a preservation | save liquid storage container to the container for saliva collection. It is explanatory drawing which shows the state which the upper end part of the container for saliva collection contact | abutted to the contact part of the crushing member. It is explanatory drawing which shows the state which the sealing part of the crushing member entered into the clearance gap. It is explanatory drawing which shows the state which the crushing member crushed the cover body. It is explanatory drawing which shows the state which the preservation | save liquid fell on the container for saliva collection. It is explanatory drawing which shows the other outer periphery shape of a preservation | save liquid storage container. It is a perspective view when attaching the preservation | save liquid storage container in 2nd Embodiment to the container for saliva collection. It is sectional drawing of a preservation | save liquid storage container. It is explanatory drawing which shows the state which the sealing part of the crushing member entered into the protruding item | line part. It is explanatory drawing which shows the state which the crushing member crushed the sealing bottom face.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same element and the overlapping description is abbreviate | omitted. Further, the positional relationship such as up, down, left and right is based on the positional relationship shown in the drawings unless otherwise specified. Furthermore, the dimensional ratios in the drawings are not limited to the illustrated ratios. Moreover, the following embodiment is an illustration for explaining the present invention, and the present invention is not limited to this embodiment.

<First Embodiment>
FIG. 1 shows an example of a saliva storage kit 1 according to the present embodiment. For example, the saliva storage kit 1 includes a saliva collection container 10 used when collecting saliva, a funnel 11, and a storage solution storage container 12 that stores a storage solution of saliva. The saliva collection container 10, the funnel 11, and the storage liquid storage container 12 are formed of, for example, polypropylene resin.

  FIG. 2 shows a cross-sectional view of the saliva collection container 10 with the funnel 11 removed. The saliva collection container 10 is formed in a cylindrical shape having an opening 10a on the upper surface. The saliva collection container 10 has a saliva storage chamber 20 in the upper part and a lower part is a hand-held part 21. On the upper outer peripheral surface of the saliva collection container 10, a screw portion 22 for fitting into the storage liquid storage container 12 is formed.

  As shown in FIG. 3, the funnel 11 is attached to the upper opening 10 a of the saliva collection container 10. On the outer peripheral surface of the lower part of the funnel 11, there is formed a locking part 11 a that is fitted into the upper part of the saliva collection container 10 from the outside and locked. The funnel 11 can be removed from the saliva collection container 10 by pulling upward.

  As shown in FIGS. 4 and 5, the storage liquid storage container 12 is formed in a cylindrical shape having a closed upper surface and an opening 12a on the lower surface. The storage liquid storage container 12 includes, for example, a main body 30, a lid 31, and a crushing member 32.

  As shown in FIG. 5, a storage liquid storage chamber 41 having an outflow port 40 on the lower surface is formed in the upper part inside the main body 30. The storage solution storage chamber 41 is filled with a storage solution A for storing the mixed solution by mixing with saliva. The lower part inside the main body 30 has a diameter that is larger than the diameter of the preservation liquid storage chamber 41 and is approximately the same as the outer diameter of the saliva collection container 10. A step portion 42 to which the lid 31 is attached is formed between the upper portion and the lower portion of the main body portion 30, that is, immediately below the storage solution storage chamber 41.

  A screw portion 43 that meshes with the screw portion 22 of the saliva collection container 10 is formed on the inner peripheral surface of the lower portion of the main body portion 30. In addition, on the inner peripheral surface of the lower portion of the main body portion 30, an annular first concave portion 44 and a second concave portion 45 into which a convex portion 90 of a crushing member 32 described later is fitted are formed.

  The lid 31 is formed in a disc shape as shown in FIGS. 4 and 5 and seals the outlet 40. As shown in FIG. 5, the lid 31 has an annular flange portion 50 on the outer periphery, and has a cylindrical portion 51 having a diameter smaller than the outer diameter of the flange portion 50 at the lower portion of the flange portion 50. A crushing surface 52 is provided on the lower surface of 51.

  The flange portion 50 is larger than the outflow port 40 and has the same diameter as the inner diameter of the lower portion of the main body portion 30, and is ultrasonically welded to the horizontal surface 42 a of the step portion 42. The crushing surface 52 is formed to a thickness of about 1 mm to 2 mm, and is easily crushed by the pressing of the pressing portion 60 of the crushing member 32 described later. As shown in FIG. 6, a circular notch 53 is formed on the outer peripheral portion of the upper surface of the crushing surface 52, and the crushing surface 52 is crushed starting from the notch 53. The thickness of the crushing surface 52 at the notch 53 is set to about 0.03 mm to 0.1 mm.

  As shown in FIG. 5, the cylindrical portion 51 is formed so that the outer diameter is smaller than the outer diameter of the flange portion 50, and the cylindrical portion 51 extends vertically to a predetermined length, so that the outer peripheral surface of the lid body 31. An annular gap B is formed between the main body portion 30 and the inner peripheral surface of the main body portion 30. The gap B has, for example, a radial thickness of about 1 mm and a height of about 3 mm.

  As shown in FIGS. 4 and 5, the crushing member 32 is formed in a cylindrical shape having an outer diameter substantially the same as the inner diameter of the lower portion of the main body 30. The crushing member 32 is provided at a position (initial position) where the crushing member 32 does not come into contact with the lid body 31 below the lid body 31, and can move inside the main body 30 toward the lid body 31 side. For example, as shown in FIGS. 4 and 5, the crushing member 32 protrudes toward the lid 31 and is disposed around the pressing portion 60 and the inner peripheral surface of the main body 30. And an annular sealing portion 61 projecting toward the lid body 31 side, and a fluid passage port 62 through which the preservation solution A flowing out from the outlet 40 passes to the saliva collection container 10 side (downward).

  The pressing part 60 has a plurality of pins, for example, three pins 70. As shown in FIG. 5, the sealing portion 61 has a thickness that can be fitted in the gap B in an airtight manner, that is, a thickness that is slightly larger than the gap B. The sealing portion 61 protrudes closer to the lid body 31 than the pressing portion 60. Thereby, when the crushing member 32 is pushed by the saliva collection container 10 and moves to the lid body 31 side, the sealing portion 61 is positioned before the pressing portion 60 reaches the crushing surface 52 of the lid body 31. The sealing part 61 enters the gap B before the pressing part 60 presses and crushes the lid 31 and can seal the gap between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the main body part 30. You can stop. At this time, the space between the crushing member 30 and the outer peripheral surface of the lid 31 can also be sealed.

  The liquid passage port 62 is formed at the center of the crushing member 32. The liquid passage port 62 has a tapered surface 71 whose diameter gradually increases toward the lid body 31 at the upper opening on the lid body 31 side. As shown in FIG. 7, pins 70 of the pressing portion 60 are erected on the tapered surface 71 at equal intervals on the same circumference.

  As shown in FIG. 5, the lower part of the crushing member 32 is formed with a smaller outer diameter than the other parts. Thereby, a gap C is formed between the outer peripheral surface of the lower portion of the crushing member 32 and the inner peripheral surface of the main body 30. The upper part of the saliva collection container 10 is inserted into the gap C in an airtight manner. A step portion 80 is formed between the upper portion of the crushing member 30 having a large outer diameter and the lower portion having a small outer diameter, and the upper portion of the saliva collection container 10 is fitted into the main body portion 30. It is a contact part which contacts when it hits. That is, the bottom of the gap C is the contact portion 80.

  The crushing member 32 can be pushed and moved to the lid 31 side by further fitting the upper part of the saliva collection container 10 in contact with the back. The crushing member 32 moves to the lid body 31 side by pressing the saliva collection container 10, and the pin 70 crushes the crushing surface 52 of the lid body 31, so that the preservation solution A can flow out from the outlet 40.

  On the outer peripheral surface of the crushing member 32, an annular convex portion 90 that can be locked to the first concave portion 44 and the second concave portion 45 formed on the inner peripheral surface of the lower portion of the main body portion 30 is formed. The crushing member 32 can be locked at the initial position when the convex portion 90 is locked to the first concave portion 44, and the crushing member 32 when the convex portion 90 is locked to the second concave portion 45. Can be locked at a position (crush position) when the pressing portion 60 crushes the lid 31.

  Next, a saliva storage process using the saliva storage kit 1 configured as described above will be described.

  First, the saliva of the subject is collected in the saliva collection container 10 from the funnel 11 attached to the saliva collection container 10 shown in FIGS. Next, in place of the funnel 11, as shown in FIG. 8, the preservation solution storage container 12 is attached to the saliva collection container 10.

  At this time, the upper part of the saliva collection container 10 is inserted from the lower surface 12a of the main body part 30 of the preservation liquid storage container 12 shown in FIG. 5, and the screw part 43 and the screw part 22 are engaged with each other. The upper part of the saliva collection container 10 is fitted into the storage liquid storage container 12. At this time, the crushing member 32 inside the storage liquid storage container 12 has the convex portion 90 fitted into the first concave portion 44 of the main body portion 30 and is locked at the initial position.

  Then, when the storage liquid storage container 12 is further rotated and the upper part of the saliva collection container 10 is fitted further into the main body 30, the upper part of the saliva collection container 10 enters the gap C as shown in FIG. It contacts the contact part 80. Then, when the storage liquid storage container 12 is further rotated and the upper part of the saliva collection container 10 is fitted further into the main body part 30, the crushing member 32 is pushed, and the locking with respect to the main body part 30 is released and the upper part is released upward. Moving. At this time, the inner peripheral surface of the upper part of the saliva collection container 10 and the outer peripheral surface of the contact portion 80 are in close contact with each other, and airtightness is maintained between them. Thereby, the airtightness in the container when the preservation solution A and saliva described later are mixed or after mixing is ensured.

  As shown in FIG. 10, the sealing portion 61 of the crushing member 32 enters the gap B, and seals between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the main body portion 30. In this state, when the crushing member 32 further moves upward, the pin 70 of the pressing portion 60 pushes the crushing surface 52 of the lid 31 and collapses as shown in FIG. At this time, the crushing surface 52 is crushed from the circular cutout 53. At this time, the sealing portion 61 of the crushing member 32 is fitted to the back of the gap B and contacts the flange portion 42 of the lid 31, for example. Further, the convex portion 90 of the crushing member 32 is fitted into the second convex portion 45 of the main body portion 30, and the crushing member 32 is locked at the crushing position.

  When the crushing surface 52 is crushed, as shown in FIG. 12, the storage liquid A flows out from the outlet 40 of the storage liquid storage chamber 41 and passes through the lid 31 and the liquid passage port 62 of the crushing member 32 to collect saliva below. It flows into the container 10. As a result, the saliva and the preservation liquid in the saliva collection container 10 are mixed, and the saliva and the preservation liquid are stored in the airtight saliva collection container 10.

  According to the present embodiment, in the saliva storage kit 1, when the crushing member 32 is pushed by the saliva collection container 10 and moves to the lid body 31 side, the pressing portion 60 presses the lid body 31 to crush it. Before the sealing portion 61 enters the gap B between the outer peripheral surface of the lid 31 and the inner peripheral surface of the storage liquid storage container 12, the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the storage liquid storage container 12 It is comprised so that a space may be sealed. Thereby, since the airtightness of the container when the preservation solution A and the saliva are mixed or after the mixture is ensured, leakage and volatilization of the preservation solution A are suppressed, and the inspection using the saliva can be performed appropriately. In addition, it is possible to prevent the liquid from leaking from the container when mixing the preservation solution A and saliva at the time of inspection.

  Since the sealing portion 61 protrudes closer to the lid body 31 than the tip of the pressing portion 60, the sealing portion 61 surely enters the gap B before the pressing portion 60 crushes the lid body 31. Thereby, before the preservation | save liquid A flows out, between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the preservation | save liquid storage container 12 can be sealed reliably.

  The pressing portion 60 includes a plurality of pins 70, the liquid passage port 62 has an opening on the lid body 31 side, and has a tapered surface 71 whose diameter gradually increases toward the lid body 31 side. Since it stands upright, the pin 70 can be arrange | positioned in the position close | similar to a center, and the cover body 31 can be crushed appropriately. Further, while the cover body 31 is crushed by the pin 70, the storage solution A that has been crushed and flowed out can be efficiently flowed to the saliva collection container 10 side through the tapered surface 71.

  The crushing member 32 is engaged with the storage liquid storage container 12 at the position where the pressing part 60 has crushed the lid 31 (crushing position) by the second recess 45 of the storage liquid storage container 12 and the protrusion 90 of the compression member 32. Since it can stop, the position shift of the crushing member 32 after crushing can be prevented. As a result, the space between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the storage liquid storage container 12 can be reliably sealed.

  Due to the first concave portion 44 of the storage liquid storage container 12 and the convex portion 90 of the compression member 32, the collapse member 32 is placed in the storage liquid storage container 12 at a position (initial position) before the collapse member 32 moves to the lid 31 side. For example, it is possible to prevent the crushing member 32 from moving and crushing the lid 31 during transportation of the saliva storage kit 1 before use.

  The lid body 31 has a flange portion 50 having a diameter larger than that of the outlet 40 of the storage liquid storage chamber 41 and is fitted into a step portion 42 inside the storage liquid storage container 12. Since it is ultrasonically welded to the ring 42, the airtightness between the lid 31 and the storage liquid storage container 12 can be secured. Thereby, the airtightness of the container when the preservation solution A and saliva are mixed or after mixing can be improved.

  Since the circular notch 53 is formed in the crushing surface 52 with which the pressing part 60 in the lid 31 abuts, the crushing position of the crushing surface 52 can be guided. In such a case, since the crushing surface 52 is crushed in a circular shape, an outflow channel for the preservation liquid A can be suitably secured.

  Since the crushing member 32 has the contact part 80 with which the upper end part of the saliva collection container 10 comes into contact, the crushing member 32 can be suitably moved to the lid 31 side by pressing the saliva collection container 10. it can.

  Since the gap C is formed between the lower outer peripheral surface of the crushing member 32 and the inner peripheral surface of the preservation liquid storage container 12, and the contact portion 80 is formed at the bottom of the gap C, saliva collection The upper end of the container 10 pushes the crushing member 32 upward.

  In the first embodiment, the preservation liquid storage container 12 may have an outer peripheral shape as shown in FIG. The storage liquid storage container 12 has a substantially cylindrical outer peripheral shape, and is provided with a protruding portion 100 protruding outward on the outer peripheral surface 12b. The protrusion 100 is formed from the lower surface to the upper surface of the storage liquid storage container 20 along the vertical direction of the outer peripheral surface 12b, for example. The protrusion 100 is formed in, for example, an outwardly convex arc shape. According to the saliva storage kit 1, when the subject turns the storage fluid storage container 12 relative to the saliva collection container 10, the subject's finger is easily applied to the protruding portion 100, and thus the storage fluid storage container 12. It is easy to fit the saliva collection container 10 into the saliva collection container 10 and to close the saliva collection container 10 with the storage liquid storage container 12 as a lid.

<Second Embodiment>
In the above embodiment, the outlet 40 of the storage liquid storage chamber 41 of the storage liquid storage container 12 is sealed with the lid 31, but the lid 31 is not provided, and instead the lower surface of the storage liquid storage chamber 41 is covered. It may be a sealed bottom surface. Such an example will be described below as a second embodiment. In addition, about the member and structure similar to 1st Embodiment, description is abbreviate | omitted using the same code | symbol.

  As shown in FIG. 14, the storage liquid storage container 12 has a substantially cylindrical shape, and a protruding portion 100 protruding outward is provided on the outer peripheral surface 12b. As shown in FIGS. 14 and 15, the storage liquid storage chamber 41 of the storage liquid storage container 12 has an upper surface 110 that is open and a lower surface 111 that is a sealed bottom surface. The sealed bottom surface 111 preferably has a thickness of about 1 mm to 2 mm, for example. The upper surface 110 can be opened and closed by the lid 120. The storage liquid A is filled in the storage liquid storage chamber 41 by opening the lid 120, and then the lid 120 is welded and sealed in the storage liquid storage chamber 41. A notch similar to the notch 53 is formed in the sealed bottom surface 111.

  As shown in FIG. 15, a crushing member 32 that crushes the sealed bottom surface 111 is provided below the storage liquid storage chamber 41 in the main body 30. An annular sealing portion 61 is formed at the tip of the crushing member 32, and the sealing portion 61 is formed slightly inside the inner peripheral surface of the main body portion 30 where the crushing member 32 is disposed. On the outer periphery of the sealed bottom surface 111 of the storage liquid storage chamber 41, an annular concave strip portion 130 into which the sealing portion 61 of the crushing member 32 enters is formed.

  When saliva is stored, the saliva of the subject is collected in the saliva collection container 10, and then the saliva collection container 10 is inserted into the storage liquid storage container 12 as shown in FIG. The container 12 is turned to fit the upper part of the saliva collection container 10 into the back, and the crushing member 32 is pushed and moved to the sealed bottom surface 111 side. Eventually, the sealing portion 61 of the crushing member 32 enters the ridge 130 and the space between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the main body 30 is sealed. And if the crushing member 32 further advances, as shown in FIG. 17, the pin 70 of the press part 60 will push the sealing bottom face 111, and will be crushed. At this time, the sealing part 61 of the crushing member 32 is fitted into the ridge part 130 exactly. When the sealed bottom surface 111 is crushed, the preservation liquid A in the preservation liquid storage chamber 41 flows out, and flows into the saliva collection container 10 below through the liquid passage port 62 of the crushing member 32. As a result, the saliva and the preservation liquid in the saliva collection container 10 are mixed, and the saliva and the preservation liquid are stored in the airtight saliva collection container 10. The operations other than the portion using the sealed bottom surface 111 instead of the lid 31 are the same as those in the first embodiment.

  According to the present embodiment, when the crushing member 32 is pushed by the saliva collection container 10 and moves to the sealed bottom surface 111 side, the saliva storage kit 1 presses the sealed bottom surface 111 and crushes it. The sealing part 61 enters the protruding line part 130 before and is configured to seal between the outer peripheral surface of the crushing member 32 and the inner peripheral surface of the storage liquid storage container 12. Thereby, since the airtightness of the container when the preservation solution A and the saliva are mixed or after the mixture is ensured, leakage and volatilization of the preservation solution A are suppressed, and the inspection using the saliva can be performed appropriately. In addition, it is possible to prevent the liquid from leaking from the container when mixing the preservation solution A and saliva at the time of inspection.

  The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It is obvious for those skilled in the art that various modifications or modifications can be conceived within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. It is understood.

  For example, the configuration of the lid 31 and the crushing member 32 in the above embodiment is not limited to this. For example, the pressing portion 60 of the crushing member 32 may not be a plurality of pins 70, may be a single pin 70, and may not be a pin-like one. The sealing part 61 may have another configuration as long as the gap between the outer peripheral surface of the crushing member 32 and the storage liquid storage container 12 can be sealed before the lid 31 is crushed. The position and shape of the contact portion 80 of the crushing member 32 are not limited to this.

  Although the liquid passing port 62 has the tapered surface 71, the tapered surface may not be provided. The pin 70 may not be provided on the tapered surface 71.

  The locking mechanism that locks the crushing member 32 with respect to the storage liquid storage container 12 is configured by the first concave portion 44, the second concave portion 45, and the convex portion 90, but is not limited thereto, and other configurations are possible. You may have.

  The flange portion 50 of the lid 31 is ultrasonically welded in an annular shape to the horizontal surface 42a of the step portion 42 of the storage liquid storage container 12, but may be bonded by other methods.

  A continuous circular cutout 53 is formed on the crushing surface 52 of the lid 31, but the cutout 53 may be formed in a plurality of intermittent portions on the same circumference. Further, the shape of the notch 53 is not limited to a circular shape, and may be another shape. The notch 53 may be provided on the lower surface of the crushing surface 52, or may be provided on both the upper and lower surfaces.

  The saliva preservation kit in the present embodiment can be applied to tests other than DNA tests.

  The present invention is useful when the preservation solution and saliva in the saliva preservation kit are mixed or when the airtightness of the container after mixing is ensured.

DESCRIPTION OF SYMBOLS 1 Saliva preservation kit 10 Saliva collection container 12 Storage liquid storage container 30 Main body part 31 Cover body 32 Crushing member 60 Pressing part 61 Sealing part 62 Liquid passing port 111 Sealing bottom face A Preservation liquid B Crevice C Crevice

Claims (12)

A saliva storage kit,
A saliva collection container having an opening on the upper surface, and a storage liquid storage container having an opening on the lower surface, and an upper portion having an upper surface opening of the saliva collection container is opened on the lower surface inside the storage liquid storage container Can be fitted from
The storage liquid storage container has a storage liquid storage chamber having an upper surface that is opened and closed by a lid and a sealed bottom surface that is sealed, and the lower side of the storage liquid storage chamber is pressed from below by the saliva collection container. And a crushing member for allowing the storage liquid to flow out of the storage liquid storage chamber by crushing the sealing bottom surface,
The crushing member protrudes toward the sealed bottom surface and presses the sealed bottom surface, an annular sealing portion that is disposed around the pressed portion and protrudes toward the sealed bottom surface, and stores the storage liquid A liquid passage port for passing the preservative solution flowing out of the chamber to the saliva collection container side,
On the outer periphery of the bottom surface of the blockade, a concave strip portion into which the sealing portion enters is provided,
When the crushing member is pushed by the saliva collection container and moves to the sealed bottom surface side, the sealing portion enters the concave portion before the pressing portion presses and crushes the sealed bottom surface. A saliva storage kit configured to seal between an outer peripheral surface of the crushing member and an inner peripheral surface of the preserving liquid container. A saliva storage kit,
A saliva collection container having an opening on the upper surface, and a storage liquid storage container having an opening on the lower surface, and an upper portion having an upper surface opening of the saliva collection container is opened on the lower surface inside the storage liquid storage container Can be fitted from
Inside the storage liquid storage container, a storage liquid storage chamber having an outlet on its lower surface is formed in the upper part thereof, and on the lower side of the storage liquid storage chamber, a lid that seals the outlet, A crushing member is provided that can be moved to the lid side by pressing from below with a saliva collection container, and that crushes the lid body and causes the storage solution to flow out from the outlet.
The crushing member protrudes toward the lid and presses the lid, and is disposed around the pressing portion and protrudes toward the lid along the inner peripheral surface of the storage liquid storage container. And a liquid passage port through which the preservation solution that has flowed out of the outlet is passed to the saliva collection container side,
A gap is provided between the outer peripheral surface of the lid and the inner peripheral surface of the storage liquid storage container,
When the crushing member is pushed by the saliva collection container and moves to the lid side, the sealing portion and the outer peripheral surface of the lid body before the pressing portion presses and crushes the lid body A saliva preservation kit configured to enter the gap between the inner peripheral surface of the storage liquid storage container and seal between the outer peripheral surface of the crushing member and the inner peripheral surface of the storage liquid storage container. The lid body has an annular flange portion having a diameter larger than that of the outflow port of the preservation liquid storage chamber, and is fitted into a step portion formed inside the preservation liquid storage container and having a diameter larger than that of the outflow port. And
The saliva preservation kit according to claim 2, wherein the flange portion is ultrasonically welded to the stepped portion in an annular shape.   The saliva preservation kit according to claim 2 or 3, wherein an annular notch is formed on a surface of the lid that is pressed by the pressing portion.   The saliva preservation kit according to any one of claims 1 to 4, wherein the sealing part protrudes toward the preserving liquid storage chamber from the tip of the pressing part. The pressing portion includes a plurality of pins,
The liquid passage port has a tapered surface whose diameter gradually increases toward the storage liquid storage chamber side on the opening surface of the storage liquid storage chamber side, and the pin is erected on the taper surface. The saliva preservation kit according to any one of claims 1 to 5.   The saliva preservation according to any one of claims 1 to 6, further comprising a locking mechanism that locks the crushing member with respect to the storage liquid storage container at a position where the pressing portion collapses the storage liquid storage chamber. kit.   8. The locking mechanism according to claim 1, further comprising a locking mechanism that locks the crushing member with respect to the storage liquid container at a position before the crushing member moves to the storage liquid storage chamber side. Saliva storage kit. The crushing member has an abutting portion with which an upper end portion of the saliva collection container abuts when an upper part of the saliva collection container is fitted into the preservation liquid storage container.
The crushing member is moved further to the storage liquid storage chamber side by being further fitted into the saliva collection container with the upper end of the saliva collection container in contact with the contact portion. The saliva preservation kit according to any one of claims 1 to 8, which is configured.   A gap into which the upper end of the saliva collection container is fitted is formed between the lower outer peripheral surface of the crushing member and the inner peripheral surface of the storage liquid storage container, and the abutment is in contact with the bottom of the gap The saliva preservation kit according to claim 9, wherein the part is formed.   The saliva preservation kit according to any one of claims 1 to 10, further comprising a detachable funnel at an upper part of the saliva collection container.   The saliva preservation kit according to any one of claims 1 to 11, wherein a projecting portion that projects outward is formed on an outer peripheral surface of the preservation liquid storage container.

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