CN114041600A - 一种负载花色苷的植物甾醇递送体系的制备方法 - Google Patents
一种负载花色苷的植物甾醇递送体系的制备方法 Download PDFInfo
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Abstract
一种负载花色苷的植物甾醇递送体系的制备方法,属于食品加工技术领域。其包括以下工艺步骤:β‑谷甾醇衍生物的合成;负载花色苷的植物甾醇递送体系的制备。本发明制备的负载花色苷的植物甾醇递送体系选用的原料β‑谷甾醇是具有生物相容性和优生物活性的天然小分子;本发明制备的β‑谷甾醇衍生物引入了二硫键和亲水的羧基基团,兼有谷胱甘肽刺激响应性和pH刺激响应性;本发明首次运用β‑谷甾醇衍生物作为载体包埋水溶性活性成分花色苷,解决了花色苷稳定性差且生物利用度低的问题,且壁材和芯材之间可以产生协同效应,扩大其功能应用。
Description
技术领域
本发明属于食品加工技术领域,具体涉及一种负载花色苷的植物甾醇递送体系的制备方法。
背景技术
乳液是两种不相混溶的液体通过均质、超声、微流态化或高剪切混合在分散体系中混合而成。乳液由于低毒、稳定性强而被视为一种有潜力的运送方式,在食品及医药领域具有广阔的应用前景。近年来,已有诸多天然高分子和小分子被应用于乳液载体的构建。其中植物甾醇具有降血脂、抗肿瘤、抗氧化等多种药理作用,可通过酯化反应合成两亲性聚合物用于乳液载体的构建。
花色苷是自然界中重要的水溶性色素之一,主要存在于水果和蔬菜中,作为一种天然的色素,花色苷具有诸多生理功能,如抗氧化、抗癌、抗炎、抗菌等。然而,虽然花色苷具有良好的功能特性,但是由于花色苷稳定性差,易发生不同程度的降解。与此同时,由于胃肠道不稳定等因素,花色苷的生物利用度低,仅为1.95%~12.3%。因此,针对上述问题,将花色苷包封在乳液中,有助于提高花色苷的生物利用度和稳定性,扩展功能应用。
发明内容
本发明的目的是为了解决花色苷稳定性差、利用度低的问题,提供一种负载花色苷的植物甾醇递送体系的制备方法。
为实现上述目的,本发明采取的技术方案如下:
一种负载花色苷的植物甾醇递送体系的制备方法,所述方法步骤为:
步骤一、β-谷甾醇衍生物的合成:
(1)将β-谷甾醇溶于二氯甲烷中,配置浓度为5mg/mL~7mg/mL的溶液;
(2)将3,3-二硫代二丙酸溶于N,N-二甲基甲酰胺(DMF)中,配置浓度为100mg/mL~140mg/mL的3,3-二硫代二丙酸的DMF溶液;
(3)将β-谷甾醇溶液与3,3-二硫代二丙酸溶液混合,在冰浴条件下搅拌10~20min;
(4)将催化剂二环己基碳二亚胺(DCC)和4-二甲氨基吡啶(DMAP)加入步骤(3)反应后的溶液,在冰浴条件下反应3~4h;
(5)将β-谷甾醇衍生物利用正向硅胶柱层析进行分离纯化,然后旋干后冻干,得到β-谷甾醇衍生物;
步骤二、负载花色苷的植物甾醇递送体系的制备:
(1)称取β-谷甾醇衍生物溶解于二氯甲烷溶液,配置浓度为5mg/mL~10mg/mL的β-谷甾醇衍生物溶液;
(2)称取花色苷溶解于1%PVA溶液中;
(3)将步骤(2)配置的花色苷溶液在涡旋的条件下逐滴滴入β-谷甾醇衍生物溶液中,随后在细胞破碎仪下超声乳化,制备初乳;
(4)将初乳在涡旋的条件下逐滴滴入0.1%~0.3%PVA溶液中,随后在细胞破碎仪下超声乳化,制备复乳;
(5)将复乳在室温下磁力搅拌6~12h,直至有机溶剂挥发,随后将复乳在冷冻离心机于10000rpm离心20~30min,用双蒸水洗涤下层沉淀3遍除去残留的PVA,将沉淀冷冻干燥得负载花色苷的植物甾醇递送体系。
进一步地,步骤一(4)中,所述β-谷甾醇:3,3-二硫代二丙酸:DCC:DMAP的摩尔比为1:3~5:1~4:3。
进一步地,步骤一(5)中,所述上样方式为湿法上样,展开剂比例为石油醚:丙酮=5:1。
进一步地,步骤二(3)中,所述花色苷溶液与β-谷甾醇衍生物溶液的体积比为1:10~30。
进一步地,步骤二(3)中,所述超声乳化的功率为60W~100W,时间为1~3min,其中每超声5s间隔5s。
进一步地,步骤二(4)中,所述PVA溶液的浓度为0.1%~0.3%,初乳和PVA溶液的体积比为1:3~5。
进一步地,步骤二(4)中,所述超声乳化的功率为40W~100W,时间为1~3min,其中每超声5s间隔5s。
本发明相对于现有技术的有益效果为:
(1)本发明制备的负载花色苷的植物甾醇递送体系选用的原料β-谷甾醇是具有生物相容性和优生物活性的天然小分子;
(2)本发明制备的β-谷甾醇衍生物引入了二硫键和亲水的羧基基团,兼有谷胱甘肽刺激响应性和pH刺激响应性;
(3)本发明首次运用β-谷甾醇衍生物作为载体包埋水溶性活性成分花色苷,解决了花色苷稳定性差且生物利用度低的问题,且壁材和芯材之间可以产生协同效应,扩大其功能应用。
附图说明
图1是β-谷甾醇衍生物的反应机理图;
图2是负载花色苷的植物甾醇递送体系的扫描电镜图。
具体实施方式
以下实施例进一步说明本发明的内容,但不应理解为对本发明的限制。在不背离本发明实质的情况下,对本发明方法、步骤或条件所作的修改和替换,均属于本发明的范围。
实施例1
一、β-谷甾醇衍生物的合成:
以7mL二氯甲烷和1mLN,N-二甲基甲酰胺(DMF)作为溶剂,将β-谷甾醇和3,3-二硫代二丙酸溶解,在冰浴条件下混匀15min。然后加入DCC和DMAP,β-谷甾醇:3,3-二硫代二丙酸:DCC:DMAP的摩尔比为1:4.5:2.5:3。在冰浴条件下反应3.5h,通过薄层层析确定反应结束时间,通过硫酸乙醇显色,根据产物的极性确定产物点位置。反应结束后,将剩余溶剂旋干备用。β-谷甾醇衍生物的反应机理如图1所示。
二、负载花色苷的植物甾醇递送体系的制备:
用二氯甲烷作为溶剂配制5mg/mLβ-谷甾醇衍生物溶液,称取一定量的花色苷溶解于1%PVA溶液,吸取100μL花色苷溶液逐滴滴入1mLβ-谷甾醇衍生物溶液,漩涡振荡1min,随后在细胞破碎仪下进行超声乳化,乳化功率60W,总时长1min,其中每乳化5s停顿5s,保证超声过程在冰浴下进行,制备初乳,随后将乳化后的溶液逐滴滴入5mL 0.3%PVA溶液中,旋涡振荡1min,在细胞破碎仪下进行超声乳化,乳化功率60W,总时长1min,其中每乳化5s停顿5s,保证超声过程在冰浴下进行,制备复乳。然后将乳液在转速400r/min搅拌6h,在10000rpm下冷冻离心30min,用双蒸水洗涤沉淀3遍以除去残留的PVA,将沉淀冷冻干燥得负载花色苷的植物甾醇颗粒。如图2所示,当花色苷与植物甾醇衍生物组装后,该颗粒呈均匀球形,说明该递送体系的成功制备。
Claims (7)
1.一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:所述方法步骤为:
步骤一、β-谷甾醇衍生物的合成:
(1)将β-谷甾醇溶于二氯甲烷中,配置浓度为5mg/mL~7mg/mL的溶液;
(2)将3,3-二硫代二丙酸溶于N,N-二甲基甲酰胺中,配置浓度为100mg/mL~140mg/mL的3,3-二硫代二丙酸的DMF溶液;
(3)将β-谷甾醇溶液与3,3-二硫代二丙酸溶液混合,在冰浴条件下搅拌10~20min;
(4)将催化剂二环己基碳二亚胺和4-二甲氨基吡啶加入步骤(3)反应后的溶液,在冰浴条件下反应3~4h;
(5)将β-谷甾醇衍生物利用正向硅胶柱层析进行分离纯化,然后旋干后冻干,得到β-谷甾醇衍生物;
步骤二、负载花色苷的植物甾醇递送体系的制备:
(1)称取β-谷甾醇衍生物溶解于二氯甲烷溶液,配置浓度为5mg/mL~10mg/mL的β-谷甾醇衍生物溶液;
(2)称取花色苷溶解于1%PVA溶液中;
(3)将步骤(2)配置的花色苷溶液在涡旋的条件下逐滴滴入β-谷甾醇衍生物溶液中,随后在细胞破碎仪下超声乳化,制备初乳;
(4)将初乳在涡旋的条件下逐滴滴入0.1%~0.3%PVA溶液中,随后在细胞破碎仪下超声乳化,制备复乳;
(5)将复乳在室温下磁力搅拌6~12h,直至有机溶剂挥发,随后将复乳在冷冻离心机于10000rpm离心20~30min,用双蒸水洗涤下层沉淀3遍除去残留的PVA,将沉淀冷冻干燥得负载花色苷的植物甾醇递送体系。
2.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤一(4)中,所述β-谷甾醇:3,3-二硫代二丙酸:DCC:DMAP的摩尔比为1:3~5:1~4:3。
3.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤一(5)中,所述上样方式为湿法上样,展开剂比例为石油醚:丙酮=5:1。
4.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤二(3)中,所述花色苷溶液与β-谷甾醇衍生物溶液的体积比为1:10~30。
5.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤二(3)中,所述超声乳化的功率为60W~100W,时间为1~3min,其中每超声5s间隔5s。
6.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤二(4)中,所述PVA溶液的浓度为0.1%~0.3%,初乳和PVA溶液的体积比为1:3~5。
7.根据权利要求1所述的一种负载花色苷的植物甾醇递送体系的制备方法,其特征在于:步骤二(4)中,所述超声乳化的功率为40W~100W,时间为1~3min,其中每超声5s间隔5s。
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