CN114028320B - Plant antibacterial lotion for female private parts - Google Patents
Plant antibacterial lotion for female private parts Download PDFInfo
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- CN114028320B CN114028320B CN202111356321.1A CN202111356321A CN114028320B CN 114028320 B CN114028320 B CN 114028320B CN 202111356321 A CN202111356321 A CN 202111356321A CN 114028320 B CN114028320 B CN 114028320B
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- lotion
- private parts
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 67
- 239000006210 lotion Substances 0.000 title claims abstract description 58
- 241000196324 Embryophyta Species 0.000 claims abstract description 49
- 239000000284 extract Substances 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
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- 239000000843 powder Substances 0.000 claims abstract description 15
- 229940051257 eucalyptus globulus leaf extract Drugs 0.000 claims abstract description 13
- 241000208680 Hamamelis mollis Species 0.000 claims abstract description 12
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- 230000002401 inhibitory effect Effects 0.000 description 2
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- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a plant antibacterial lotion for female private parts, which takes eucalyptus globulus leaf extract and tilia europaea flower extract as main antibacterial agents, and is added with aloe vera leaf juice powder, false leaf tree root extract, chamomile extract, witch hazel water and other additives to play a role in bacteriostasis. The plant antibacterial lotion has strong antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans, the main raw materials are plant herbs, and the plant antibacterial lotion has no toxic or side effect, in addition, the composition components of the plant antibacterial lotion also comprise a PH regulator, the PH regulator can be used for regulating the PH value of the plant antibacterial lotion, when the plant antibacterial lotion is used, the weak acidic environment of private parts can be maintained, the self-cleaning capability of the private parts is enhanced, and meanwhile, the drying of the private parts can be relieved, and the plant antibacterial lotion also has compact and anti-aging effects.
Description
Technical Field
The invention belongs to the field of antibacterial lotion, and particularly relates to a plant antibacterial lotion for female private parts.
Background
In recent years, the female private parts are more and more inflamed and peculiar smell caused by bacteria, fungus infection and other factors, different degrees of pains are brought to the life of females, the chemical component antibacterial lotion in the market is more, the chemical component antibacterial lotion has irritation to skin and has larger taste, the plant extract is adopted as the antibacterial component, the strong antibacterial effect is not achieved, and many antibacterial lotions are neutral or weak alkaline and cannot effectively maintain the weak acidic environment of the private parts.
The most main normal flora in the vagina is lactobacillus, belongs to beneficial bacteria, and can ferment saccharides to generate lactic acid, so that normal internal environment in the vagina, including pH value, is maintained, the vagina has self-cleaning function, the deficiency of the lactobacillus can cause inflammation of the vagina and can not maintain the normal weak acidic environment of the vagina, and lactic acid is added into washing liquor as a pH regulator, so that the weak acidic environment of private parts can be maintained.
The patent application with publication number CN108066376A discloses a bacteriostatic lotion for private parts of human body, which adopts polyhexamethylene biguanide hydrochloride as a bactericidal and bacteriostatic agent, and simultaneously adds lactic acid as a pH regulator to protect weak acid environment of the private parts. The antibacterial lotion has strong antibacterial ability, can maintain weak acidic environment in private parts, but the main antibacterial agent is chemical component, has great irritation to skin, and is easy to cause allergy.
Patent application publication No. CN106421511A discloses an aloe antibacterial composition and a preparation method thereof. The aloe antibacterial composition is used as a bacteriostatic agent to prepare antibacterial liquid with strong antibacterial effect on staphylococcus aureus, escherichia coli and candida albicans. The main bacteriostatic agent is plant extract, and has small skin irritation. But no lactic acid adjusts the weak acidic environment of the private part.
At present, no report on a bacteriostatic lotion which is prepared by taking a plant extract as a bacteriostatic agent and lactic acid as a PH regulator and is used for maintaining a weak acidic environment of a private part is available, wherein a eucalyptus globulus leaf extract in the plant extract has bacteriostatic and antipruritic effects, a tilia europaea flower extract in the plant extract has moistening and bacteriostatic effects, and a bacteriostatic composition is prepared from the eucalyptus globulus leaf extract, the tilia europaea flower extract and other plant extracts, and the bacteriostatic lotion is not available in the field of female private care lotions.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a plant bacteriostatic lotion for female private parts.
In order to achieve the purpose of the invention, the following technical scheme is adopted:
the plant antibacterial lotion for female private parts comprises the following components in percentage by weight:
0.40 to 0.60 percent of false leaf tree root extracting solution; 0.20 to 0.30 percent of eucalyptus globulus leaf extract; 0.20 to 0.30 percent of basswood flower extracting solution; 0.04 to 0.06 percent of aloe leaf juice powder; 0.04 to 0.06 percent of chamomile extract; hamamelis mollis water 0.04-0.06%; 73.0 to 75.0 percent of water; 14.0 to 16.0 percent of ammonium lauryl sulfate aqueous solution; 7.00 to 8.00 percent of lauryl sulfate TEA salt water solution; 0.5 to 0.6 percent of maleic castor oil ester; 0.7 to 0.8 percent of hydroxyethyl cellulose; 0.6 to 0.8 percent of panthenol; lactic acid 0.25-0.35%; EDTA disodium 0.09-0.11%; diazolidinyl imidazole urea 0.09-0.11%; 0.09 to 0.11 percent of essence.
Preferably, the plant antibacterial lotion comprises the following components in percentage by weight:
0.50% of false leaf tree root extract; 0.25% of eucalyptus globulus leaf extract; 0.25% of basswood flower extract; 0.05% of aloe leaf juice powder; 0.05% of chamomile extract; hamamelis mollis water 0.05%; water 73.78%; 15.0% of an aqueous solution of ammonium lauryl sulfate; 7.50% of lauryl sulfate TEA brine solution; 0.55% of maleic castor oil ester; hydroxyethyl cellulose 0.75%; panthenol 0.67%; lactic acid 0.30%; EDTA disodium 0.10%; diazolidinyl imidazole urea 0.10%; 0.10% of essence.
Preferably, the basswood flower extract is a basswood flower extract.
Preferably, the aloe leaf juice powder is aloe vera leaf juice powder.
Preferably, the water is pure water.
Preferably, the PH adjuster is lactic acid.
In the invention, the selection of the components of the plant antibacterial lotion is related, and the following description is made on the heavy components:
Aloe: is anthraquinone compound in aloe of Liliaceae, and has effects of keeping moisture, relieving inflammation, and resisting allergy. The aloe selected in the invention is embodied in the form of aloe leaf juice powder, and the preferred aloe leaf juice powder is aloe leaf juice powder which has better inhibition effect on staphylococcus aureus and escherichia coli and can be widely applied in the fields of medicine and cosmetics.
Leaf tree: is of the family of the pseudo-leaf tree the genus Ruscus. The activation of the extracted solution of the false leaf tree root to the cathepsin shows that the extract of the false leaf tree root can enhance the metabolism of skin cells and resist aging, meanwhile, the extract of the false leaf tree root has good activation effect to sphingomyelinase, and the combination of the activation of the extract of the false leaf tree root to the luciferase and the aromatase shows that the extract of the false leaf tree root has the anti-aging effect to the skin, and in addition, the essential oil of the false leaf tree root extract has the anti-inflammatory and antibacterial properties. In the invention, the false leaf tree root extract is firstly dissolved in propylene glycol aqueous solution, then the false leaf tree root extract is obtained by ultrasonic heating extraction, and the false leaf tree root extract is used as a component of the plant antibacterial lotion for female private parts.
Eucalyptus globulus Roxb: is a big tree of Eucalyptus genus of Myrtaceae family, and has good antibacterial property according to traditional medical application of plants, and has activity on various gram positive bacteria and gram negative bacteria, and antibacterial effect on bark and leaf extract, and the extract has activity on Candida albicans and various dermatophytes. In the invention, the eucalyptus globulus extract is firstly dissolved in propylene glycol aqueous solution, and then the eucalyptus globulus extract is obtained by means of ultrasonic heating extraction, and the eucalyptus globulus extract is used as a component of the plant antibacterial lotion for female private parts.
Tilia Miqueliana Maxim: is of Tilia of Tiliaceae. Tilia Miqueliana and its alcohol extract have growth inhibiting effect on Salmonella, staphylococcus aureus and Paralysis, and antibacterial activity on gram positive and gram negative bacteria. Inhibition of caspase, inhibition of elastase and activation of cathepsin show that it can enhance skin cell metabolism, has antiaging effect, and can be used for moistening skin to make skin smooth and elastic in combination with its excellent moisturizing performance. In the invention, the Tilia europaea extract is firstly dissolved in a propylene glycol aqueous solution, and then the Tilia europaea extract is obtained by ultrasonic heating extraction, and the Tilia europaea extract is used as a component of the plant antibacterial lotion for female private parts.
Hamamelis mollis: is Lawsonia inermis of Hamamelidaceae, lawsonia genus, shrub or small arbor. The witch hazel contains flavonoid and other components, has cleaning effect and antioxidant capability, and the procyanidine contained in the witch hazel has effects of relaxing and diminishing inflammation on skin, can remove cell free radicals, can inhibit the growth of skin color spots and wrinkles, and can delay skin aging.
Chamomile flower: is annual or biennial herb of chamomile genus of Compositae family, whole grass fragrance, chamomile seed volatile oil, total flavone, cyclic ether bluish azulene, alpha-bisabolol, umbrella-shaped flower endophenol and the like have inhibiting effect on trichophyton, trichophyton rubrum, candida albicans, the volatile oil has the effects of diminishing inflammation, inhibiting fungi, relieving spasm and pain and the like, and the ethanol extract of the upper part of chamomile has the functions of resisting blood sugar and oxidization.
In the present invention, the PH adjustor is added to the plant bacteriostatic lotion in order to adjust the weak acidity of the plant bacteriostatic lotion, i.e., to adjust the PH of the plant bacteriostatic lotion, while also maintaining the weak acidic environment of the female private part when the plant bacteriostatic lotion is used, in the present invention, lactic acid is preferable as the PH adjustor.
The invention has the beneficial effects that:
(1) The invention takes eucalyptus globulus leaf extract, tilia europaea flower extract, pseudo-leaf tree root extract, aloe vera leaf juice powder and chamomile extract as main raw materials, and the main raw materials are all herbal, so that the plant antibacterial lotion for female private parts has no toxic or side effect;
(2) The plant antibacterial lotion disclosed by the invention comprises the PH regulator, and lactic acid is selected as the PH regulator, so that the PH value of the plant antibacterial lotion can be regulated, and when the plant antibacterial lotion is used, the weak acid environment of a private part can be maintained, and the self-cleaning capability of the private part is enhanced.
(3) The plant antibacterial lotion for female private parts has antibacterial and anti-inflammatory effects, and simultaneously has strong antibacterial effects on staphylococcus aureus, escherichia coli and candida albicans; can also relieve dryness of private parts, and has tightening and antiaging effects.
Detailed Description
The invention will be further understood by the following specific examples of the invention, which are given by way of illustration and are not intended to be limiting.
Example 1
The first embodiment provides a plant antibacterial lotion for female private parts, which comprises the following components in percentage by weight:
0.50% of false leaf tree root extract; 0.25% of eucalyptus globulus leaf extract; 0.25% of Tilia europaea extract; 0.05% of aloe vera leaf juice powder; 0.05% of chamomile extract; hamamelis mollis water 0.05%; 73.78% of pure water; 15.0% of an aqueous solution of ammonium lauryl sulfate; 7.50% of lauryl sulfate TEA brine solution; 0.55% of maleic castor oil ester; hydroxyethyl cellulose 0.75%; panthenol 0.67%; lactic acid 0.30%; EDTA disodium 0.10%; diazolidinyl imidazole urea 0.10%; 0.10% of essence.
Example two
The second embodiment provides a plant antibacterial lotion for female private parts, which comprises the following components in percentage by weight:
0.40% of false leaf tree root extract; 0.20% of eucalyptus globulus leaf extract; 0.20% of Tilia europaea extract; 0.04% of aloe vera leaf juice powder; 0.04% of chamomile extract; hamamelis mollis water 0.04%; 75.00% of pure water; 14.00% aqueous ammonium lauryl sulfate; 7.76% of lauryl sulfate TEA brine solution; 0.50% of castor oil maleate; 0.70% of hydroxyethyl cellulose; panthenol 0.60%; lactic acid 0.25%; disodium EDTA 0.09%; diazolidinyl imidazole urea 0.09%; 0.09% of essence.
Example III
The third embodiment provides a plant antibacterial lotion for female private parts, which comprises the following components in percentage by weight:
0.60% of false leaf tree root extract; 0.30% of eucalyptus globulus leaf extract; 0.30% of Tilia europaea extract; 0.06% of aloe vera leaf juice powder; 0.06% of chamomile extract; hamamelis mollis water 0.06%; 73.00% of pure water; 15.74% of an aqueous solution of ammonium lauryl sulfate; 7.00% aqueous TEA lauryl sulfate; 0.60% of maleic castor oil ester; 0.80% of hydroxyethyl cellulose; panthenol 0.80%; lactic acid 0.35%; EDTA disodium 0.11%; diazolidinyl imidazole urea 0.11%; 0.11% of essence.
Example IV
The plant antibacterial lotion for female private parts in the above embodiments one to three is prepared by the following method:
The first step: uniformly mixing and stirring water, an ammonium lauryl sulfate aqueous solution and a TEA lauryl sulfate aqueous solution according to weight percentage to obtain a first solution, adding hydroxyethyl cellulose, panthenol and EDTA disodium into the first solution, heating to 50-55 ℃, and stirring the first solution at 50-55 ℃ until the first solution is completely dissolved to obtain a second solution;
and a second step of: cooling the second solution to 40-42 ℃, adding castor oil maleate and diazolidinyl imidazole urea into the second solution at 40-42 ℃ and continuously stirring for 10-15 min to obtain a third solution;
And a third step of: sequentially adding the extract of the root of the pseudo-leaf tree, the extract of the eucalyptus globulus leaf, the extract of the tilia europaea flower, the aloe vera leaf juice powder, the extract of the chamomile and the witch hazel water into the third solution, and stirring and uniformly mixing to obtain a fourth solution;
fourth step: adding essence into the fourth solution and uniformly stirring to obtain a fifth solution;
Fifth step: and adding lactic acid into the fifth solution to adjust the pH value of the fifth solution, and uniformly stirring after the pH is adjusted to obtain the plant antibacterial lotion for female private parts.
Example five bacteriostasis experiment
The plant antibacterial lotion for female private parts in the first embodiment is subjected to antibacterial tests, wherein antibacterial test objects are staphylococcus aureus, escherichia coli and candida albicans, and the test modes are as follows: according to GB15979-2002 annex C and the "sterilizing technical Specification" (2002 edition) 1.4.1.4 of the Ministry of health ", weighing antibacterial lotion according to the amount of 5 g/tablet, completely immersing the bacterial infection carrier in a sample, performing actions for 2min, 5min, 10min and 20min, respectively taking the bacterial infection carrier, adding the bacterial infection carrier into a 5.0ml PBS test tube, uniformly mixing, oscillating, washing test bacteria, performing living bacteria culture counting, repeating the test for three times, and counting the antibacterial rate of the plant antibacterial lotion. The results of the bacteriostasis test are shown in Table 1.
Table 1 results table of bacteriostasis test
Note that: sterile growth of negative control dilution and culture medium
As shown in the results of Table 1, the five pairs of staphylococcus aureus, escherichia coli and candida albicans in the embodiment act for 2 minutes in the plant antibacterial lotion for female private parts, and the antibacterial rate can reach more than 93 percent; the antibacterial agent has 20min of action in plant antibacterial lotion for female private parts, and the antibacterial rate can almost reach 100%. The plant antibacterial lotion for female private parts has strong antibacterial effect.
Example six vaginal mucosa irritation test
The vaginal mucosa irritation test is carried out on 6 female New Zealand rabbits, and the female New Zealand rabbits are divided into a sample group and a control group, wherein the sample group uses the plant antibacterial lotion (hereinafter referred to as a sample) for female private parts, 3 animals in each group are killed after 24 hours of contamination, and vaginal mucosa tissues are taken for pathological observation. The results are shown in Table 2.
Table 2 results of vaginal mucosal irritation test
Note that: 1) Average score = stimulation response score sum/total observed (number of animals x 3) for 3 sites of 3 animals;
2) Stimulation index = infection group mean integral-negative control group mean integral.
As shown in the results of table 2, the irritation index of the sample to the vaginal mucosa is 0, and the irritation intensity of the sample (the sample refers to the plant antibacterial lotion for female private in example one) is classified according to the irritation intensity of the vaginal mucosa, and the irritation intensity of the sample to the vaginal mucosa of the rabbit is non-irritating.
Example seven lead arsenic mercury content detection
The lead, arsenic and mercury contents in the plant bacteriostatic lotion used in female private parts are detected by using an AA800 atomic absorption spectrometer, an M-7600 mercury meter, a ETNOS ONE microwave digestion meter, a liquid transfer device and a10 ml colorimetric tube with a plug. The results are shown in Table 3.
TABLE 3 determination of lead, arsenic and mercury content
Detecting items | Unit (B) | Measurement results |
Lead | mg/kg | <0.15* |
Arsenic (As) | mg/kg | <0.57* |
Mercury | mg/kg | <0.040* |
Note that: * Indicating the limit of detection
The results in Table 3 show that the lead-arsenic-mercury content in the plant bacteriostatic lotion for female private parts is below the detection limit.
Example eight pH test
The pH value of the stock solution, namely the plant bacteriostatic lotion for female private parts, is measured by using a METTLER TOLEDO pH meter under the conditions of the test environment temperature of 25 ℃ and the relative humidity of 59%.
The pH value of the plant antibacterial lotion used for female private parts is 3.62 through testing. The result shows that the pH value of the plant antibacterial lotion for female private parts accords with the acidic environment of the private parts.
Example nine stability test
Placing the sample in a 37 ℃ incubator for 3 months, and measuring the antibacterial effect of the sample on candida albicans according to GB15979-2002 annex C before and after the sample is placed. Table 4 shows the bacteriostatic effect of the sample stock (i.e., the plant bacteriostatic lotion for female private parts of the invention) on Candida albicans after 3 months of storage in a 37℃incubator.
TABLE 4 antibacterial effect on Candida albicans after 3 months of preservation of stock solution in incubator at 37deg.C
Note that: the appearance of the samples has no obvious difference; the negative control dilutions and medium were grown aseptically.
The result shows that after the sample is preserved for 3 months at 37 ℃, the raw liquid of the sample acts for 2 minutes, and the antibacterial rate on candida albicans is more than 90%; has no obvious difference with the antibacterial effect of the sample before storage and has good stability.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above examples, and all technical solutions belonging to the concept of the present invention belong to the protection scope of the present invention. It should be noted that modifications and adaptations to the invention may occur to one skilled in the art without departing from the principles of the present invention and are intended to be comprehended within the scope of the present invention.
Claims (3)
1. The plant antibacterial lotion for female private parts is characterized by comprising the following components in percentage by weight:
0.40 to 0.60 percent of false leaf tree root extracting solution; 0.20 to 0.30 percent of eucalyptus globulus leaf extract; 0.20 to 0.30 percent of tilia europaea flower extract; 0.04 to 0.06 percent of aloe vera leaf juice powder; 0.04 to 0.06 percent of chamomile extract; hamamelis mollis water 0.04-0.06%; 73.0 to 75.0 percent of water; 14.0 to 16.0 percent of ammonium lauryl sulfate aqueous solution; 7.00 to 8.00 percent of lauryl sulfate TEA salt water solution; 0.5 to 0.6 percent of maleic castor oil ester; 0.7 to 0.8 percent of hydroxyethyl cellulose; 0.6 to 0.8 percent of panthenol; lactic acid 0.25-0.35%; EDTA disodium 0.09-0.11%; diazolidinyl imidazole urea 0.09-0.11%; 0.09 to 0.11 percent of essence;
The preparation method of the false leaf tree root extracting solution comprises the following steps: dissolving the root extract of the pseudo-leaf tree in propylene glycol water solution, and performing ultrasonic heating extraction;
The preparation method of the eucalyptus globulus leaf extract comprises the following steps: dissolving Eucalyptus globulus leaf extract in propylene glycol water solution, and performing ultrasonic heating extraction;
the preparation method of the Tilia europaea extracting solution comprises the following steps: dissolving Tilia europaea flower extract in propylene glycol water solution, and performing ultrasonic heating extraction.
2. The plant bacteriostatic lotion for female privacy of claim 1, wherein the plant bacteriostatic lotion consists of the following components in weight percent:
0.50% of false leaf tree root extract; 0.25% of eucalyptus globulus leaf extract; 0.25% of Tilia europaea extract; 0.05% of aloe vera leaf juice powder; 0.05% of chamomile extract; hamamelis mollis water 0.05%; water 73.78%; 15.0% of an aqueous solution of ammonium lauryl sulfate; 7.50% of lauryl sulfate TEA brine solution; 0.55% of maleic castor oil ester; hydroxyethyl cellulose 0.75%; panthenol 0.67%; lactic acid 0.30%; EDTA disodium 0.10%; diazolidinyl imidazole urea 0.10%; 0.10% of essence.
3. A plant bacteriostatic lotion for female private parts according to claim 1 or 2, wherein said water is pure water.
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