CN1138787C - 天然植物多糖 - Google Patents
天然植物多糖 Download PDFInfo
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- CN1138787C CN1138787C CNB001245384A CN00124538A CN1138787C CN 1138787 C CN1138787 C CN 1138787C CN B001245384 A CNB001245384 A CN B001245384A CN 00124538 A CN00124538 A CN 00124538A CN 1138787 C CN1138787 C CN 1138787C
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Abstract
天然植物多糖是由枸杞提经醇洄流浸泡去色；加水煮沸，滤除杂质，浓缩清液，醇沉析；离心沉积物，烘干研磨过筛得到的枸杞粗多糖与由甘草经漂洗去杂，加水，煮沸，除杂质，清液；脱色；浓缩，醇沉析，离心的沉析物烘干研磨过筛，得到的甘草粗多糖按照1∶9混合，装入胶囊，本品能激活巨噬细胞，TB淋巴细胞，增强体液免疫和细胞免疫。具有抑制肿瘤细胞端粒作用及对多种病毒的逆转录酶的抑制作用，使基因组无法正常复制，起到对病毒的抑制或直接灭活作用。
Description
本发明属于来源于植物材料的中药的提取物，特别涉及一种甘草，枸杞的有效部位提取物，有关调节人体免疫功能，抑杀肿瘤细胞，抑制爱滋病的天然植物多糖。
目前，肿瘤是常见的多发病，其在国内外西药治疗中尚无特效药，而且药物价格昂贵，使多数患者生畏；近年来，我国中医治疗肿瘤研究十分活跃，从基础理论到临床治疗都取得了一定的进展。从全国各地报道来看，疗效不一，仁智各见。为此如何提高临床疗效，探取治疗规律，乃是当务之急。
本发明的目的是，提供一种调节人体免疫功能抑制肿瘤及爱滋病的“天然植物多糖”
本发明是这样实现的：治疗肿瘤、调节人体免疫功能，抗爱滋病的天然植物多糖由枸杞、甘草的有效部位制备如下：一、(1)原料处理及提取物制备1.1将枸杞果实用清水冲洗去杂，经醇回流浸泡去除色素。1.2将去除色素之枸杞子加水煮沸7小时，稍凉，滤除杂质，获得清液。1.3浓缩清液，用醇沉析。1.4离心、获取沉积物。1.5沉积物烘干、研磨、过筛、即取得枸杞粗多糖。(2)甘草原料处理及提取物制备。2.1将切割好的甘草根、茎用清水漂洗去杂。2.2将去杂后的原料加水，沸水煮沸7～8小时，稍凉，滤除杂质，获取清液。2.3经活性炭脱色。2.4脱色液浓缩，用醇沉析。2.5离心获取沉析物。2.6沉析物烘干、研磨、过筛、即取得甘草粗多糖。二、胶囊内含物配比及包装按以下重量比混合：枸杞多糖10％，甘草多糖90％混合，装入胶囊，经物理方法灭菌、压板、包装。三、天然植物多糖理化特点及特色1.色淡黄褐色。2.味微甜。3.易溶于水，具较高粘度。4.对非原发性瘤效果佳。
经大量科学实验证明，本品不仅能激活巨噬细胞，TB淋巴细胞，从而增强体液免疫和细胞免疫的双重功能。从抑制机理分析该胶囊具有抑制肿瘤细胞端粒作用及对多种病毒的逆转录酶的抑制作用，使基因组(DNA或RNA)，无法正常复制，从而起到对病毒的抑制或直接灭活作用。
图1是天然植物多糖工艺流程图
本产品经毒理学安全性评价检测报告确认无毒物质。(见附件1)。
本产品经保健品的功效成分、稳定性测试确认品质稳定。(见附件2)。
本产品经对抗病毒研究有抑制作用和直接灭活作用，对巨噬细胞吞噬功能研究有明显促进作用有免疫促进作用，对抑瘤作用试验可见大片变性坏死细胞及造性分布的核固缩。(见附件3)。
本产品经对抗AIDS药物检测报告显示：对病毒复制有一定抑制作用，对病毒抑制率为36.2％。(见附件4)
Claims (1)
1、一种天然植物多糖，其特征在于：它是由枸杞、甘草的有效部位按如下制备方法制备得到的产品；其制备方法为：(1)枸杞原料处理及提取物制备1.1将枸杞果实用清水冲洗去杂，经醇回流浸泡去除色素；1.2将去除色素之枸杞子加水煮沸7小时，稍凉，滤除杂质，获得清液；1.3浓缩清液，用醇沉析；1.4离心、获取沉积物；1.5沉积物烘干、研磨、过筛、即取得枸杞粗多糖；(2)甘草原料处理及提取物制备；2.1将切割好的甘草根、茎用清水漂洗去杂；2.2将去杂后的原料加水，沸水煮沸7～8小时，稍凉，滤除杂质，获取清液；2.3经活性炭脱色；2.4脱色液浓缩，用醇沉析；2.5离心获取沉析物；2.6沉析物烘干、研磨、过筛、即取得甘草粗多糖；按所述配比混合：按重量比，枸杞多糖10％，甘草多糖90％混合。
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| CNB001245384A CN1138787C (zh) | 2000-09-20 | 2000-09-20 | 天然植物多糖 |
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| CNB001245384A CN1138787C (zh) | 2000-09-20 | 2000-09-20 | 天然植物多糖 |
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| CN1343728A CN1343728A (zh) | 2002-04-10 |
| CN1138787C true CN1138787C (zh) | 2004-02-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511716A (zh) * | 2011-12-29 | 2012-06-27 | 天津大学 | 一种甘草多糖颗粒剂及其制备方法 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103608024B (zh) * | 2011-04-01 | 2016-04-13 | 桂林商源植物制品有限公司 | 控制血糖、血脂及体重的药物组合物 |
| CN105876303A (zh) * | 2015-01-26 | 2016-08-24 | 济南金植医药技术有限公司 | 一种枸杞保健组合物及其制备方法 |
| CN111777695B (zh) * | 2019-04-04 | 2021-11-26 | 中国科学院上海药物研究所 | 一种黑果枸杞多糖lrp3-s1、其制备方法及其用途 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102511716A (zh) * | 2011-12-29 | 2012-06-27 | 天津大学 | 一种甘草多糖颗粒剂及其制备方法 |
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| CN1343728A (zh) | 2002-04-10 |
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Owner name: TIANJIN PHARMACEUTICAL BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BEITE SCIENCE AND TECHNOLOGY DEVELOPMENT CO LTD, TIANJIN CITY Effective date: 20051125 |
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