CN113834869B - 收集探针及其使用方法 - Google Patents
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| MX2020005448A (es) * | 2017-11-27 | 2020-08-27 | Univ Texas | Sonda de recoleccion minimamente invasiva y metodos para el uso de esta. |
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| CN112017942B (zh) * | 2020-09-04 | 2021-03-02 | 中国地质科学院地质研究所 | 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法 |
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| CN116169005B (zh) * | 2023-02-28 | 2023-07-28 | 厦门金诺花科学仪器有限公司 | 一次性疏水纳升点样针头及点样测试方法 |
| KR102702105B1 (ko) * | 2023-10-04 | 2024-09-06 | 대한민국 | 휴대용 dna 검체 채취장치 |
| WO2025085615A1 (en) * | 2023-10-17 | 2025-04-24 | Baylor College Of Medicine | Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients |
| CL2024001366A1 (es) * | 2024-05-04 | 2024-12-13 | Ignacio Alberto Moscoso Gutierrez | Dispositivo analizador de gases de combustión de tejidos humanos |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989000829A1 (en) | 1987-07-23 | 1989-02-09 | Terumo Kabushiki Kaisha | Catheter tube |
| US5711816A (en) | 1990-07-06 | 1998-01-27 | Advanced Technolgy Materials, Inc. | Source reagent liquid delivery apparatus, and chemical vapor deposition system comprising same |
| US5119827A (en) | 1990-09-05 | 1992-06-09 | Board Of Regents, The University Of Texas System | Mechanisms of antiestrogen resistance in breast cancer |
| US5100402A (en) * | 1990-10-05 | 1992-03-31 | Megadyne Medical Products, Inc. | Electrosurgical laparoscopic cauterization electrode |
| US5241990A (en) | 1992-07-10 | 1993-09-07 | Inlet Medical, Inc. | Irrigation/aspiration valve and probe for laparoscopy |
| US5470308A (en) | 1992-08-12 | 1995-11-28 | Vidamed, Inc. | Medical probe with biopsy stylet |
| US5746720A (en) | 1995-10-18 | 1998-05-05 | Stouder, Jr.; Albert E. | Method and apparatus for insertion of a cannula and trocar |
| US5742050A (en) * | 1996-09-30 | 1998-04-21 | Aviv Amirav | Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis |
| US6297499B1 (en) | 1997-07-17 | 2001-10-02 | John B Fenn | Method and apparatus for electrospray ionization |
| ATE386335T1 (de) | 1999-10-29 | 2008-03-15 | Mds Inc Through Its Mds Sciex | Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie |
| US6786884B1 (en) | 1999-10-29 | 2004-09-07 | Bard Access Systems, Inc. | Bolus tip design for a multi-lumen catheter |
| CN1623091A (zh) | 2000-11-16 | 2005-06-01 | 赛弗根生物系统股份有限公司 | 质谱分析方法 |
| US6784439B2 (en) | 2001-07-19 | 2004-08-31 | Ut Battelle, Llc | Thin-channel electrospray emitter |
| US6756586B2 (en) * | 2001-10-15 | 2004-06-29 | Vanderbilt University | Methods and apparatus for analyzing biological samples by mass spectrometry |
| US20040014227A1 (en) | 2002-01-04 | 2004-01-22 | Frederick Erik D. | Apparatus, method and computer program product for automated high-throughput sampling and data acquisition |
| US6803566B2 (en) * | 2002-04-16 | 2004-10-12 | Ut-Battelle, Llc | Sampling probe for microarray read out using electrospray mass spectrometry |
| JP4095349B2 (ja) * | 2002-06-03 | 2008-06-04 | ペンタックス株式会社 | 蛍光測定装置 |
| US6677593B1 (en) | 2002-08-28 | 2004-01-13 | Ut-Battelle, Llc | Planar flow-by electrode capacitive electrospray ion source |
| CA2433205A1 (en) | 2003-03-18 | 2004-09-18 | James Alexander Keenan | Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility |
| US7684934B2 (en) | 2003-06-06 | 2010-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pattern recognition of whole cell mass spectra |
| US7335897B2 (en) | 2004-03-30 | 2008-02-26 | Purdue Research Foundation | Method and system for desorption electrospray ionization |
| WO2005116256A2 (en) * | 2004-04-16 | 2005-12-08 | Wei-Sing Chu | Device for extracting biological molecules from tissue specimens |
| US7445603B2 (en) | 2004-05-12 | 2008-11-04 | Zkz Science Corp. | Apparatus for removable distal internal cassette for in situ fixation and specimen processing with serial collection and storage of biopsy specimens |
| WO2006031842A2 (en) | 2004-09-14 | 2006-03-23 | Metara, Inc. | In-process mass spectrometry with sample multiplexing |
| US20090286305A1 (en) * | 2005-04-15 | 2009-11-19 | Wei-Sing Chu | Method for non-destructive macromolecule extraction from biological samples on slide |
| US7295026B2 (en) | 2005-06-03 | 2007-11-13 | Ut-Battelle, Llc | Automated position control of a surface array relative to a liquid microjunction surface sampler |
| CA2611591A1 (en) | 2005-06-08 | 2006-12-14 | Vanderbilt University | Analysis of tissue samples surrounding malignancies |
| DE102005044307B4 (de) * | 2005-09-16 | 2008-04-17 | Bruker Daltonik Gmbh | Ionisierung desorbierter Moleküle |
| US7714276B2 (en) * | 2005-09-30 | 2010-05-11 | New York University | Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry |
| CA2930748C (en) | 2005-12-14 | 2017-12-05 | Stryker Corporation | Medical/surgical waste collection portable rover capable of zero setting the float used to measure the volume of liquid in the rover waste container |
| US7544933B2 (en) | 2006-01-17 | 2009-06-09 | Purdue Research Foundation | Method and system for desorption atmospheric pressure chemical ionization |
| JP2009539114A (ja) | 2006-05-26 | 2009-11-12 | イオンセンス インコーポレイテッド | 表面イオン化技術で用いるための固体を保持する器具 |
| HU226837B1 (hu) | 2006-05-31 | 2009-12-28 | Semmelweis Egyetem | Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz |
| US7800056B2 (en) * | 2006-10-26 | 2010-09-21 | Smiths Detection Montreal Inc. | Document sampler and method of sampling a document |
| EP2087504A2 (en) * | 2006-11-23 | 2009-08-12 | Philips Intellectual Property & Standards GmbH | Device for separation and maldi analysis of an analyte in a sample |
| US7847244B2 (en) * | 2006-12-28 | 2010-12-07 | Purdue Research Foundation | Enclosed desorption electrospray ionization |
| US8232521B2 (en) * | 2007-02-02 | 2012-07-31 | Waters Technologies Corporation | Device and method for analyzing a sample |
| US20080243141A1 (en) | 2007-04-02 | 2008-10-02 | Salvatore Privitera | Surgical instrument with separate tool head and method of use |
| WO2008151153A1 (en) * | 2007-06-02 | 2008-12-11 | Cerno Bioscience Llc | A self calibration approach for mass spectrometry |
| US20100285486A1 (en) | 2008-01-03 | 2010-11-11 | Grossman H Barton | Non-Invasive Detection of Bladder Cancer by Fluorescence in Situ Hybridization of Aurora A |
| US20090324617A1 (en) * | 2008-01-24 | 2009-12-31 | Glykos Finland Ltd. | Cancer specific glycans and use thereof |
| EP2247775B1 (en) | 2008-01-28 | 2012-12-19 | National University of Singapore | Method of generating a classification model |
| EP2249737B1 (en) | 2008-03-03 | 2020-07-01 | Koninklijke Philips N.V. | Biopsy guidance by electromagnetic tracking and photonic needle |
| KR20110014983A (ko) * | 2008-04-10 | 2011-02-14 | 더 유니버시티 오브 브리티시 콜롬비아 | 심장 동종이식 만성 거부반응 진단방법 |
| US8207494B2 (en) | 2008-05-01 | 2012-06-26 | Indiana University Research And Technology Corporation | Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry |
| US8410452B2 (en) * | 2008-05-29 | 2013-04-02 | Universitaetsklinikum Muenster | Ion source means for desorption/ionisation of analyte substances and method of desorbing/ionising of analyte substances |
| US8084735B2 (en) | 2008-09-25 | 2011-12-27 | Ut-Battelle, Llc | Pulsed voltage electrospray ion source and method for preventing analyte electrolysis |
| WO2010039675A1 (en) | 2008-09-30 | 2010-04-08 | Prosolia, Inc. | Method and apparatus for embedded heater for desorption and ionization of analytes |
| EP2380023A2 (en) | 2008-12-19 | 2011-10-26 | Medirista Biotechnologies AB | Oxidized cardiolipin as a novel pro-inflammatory factor |
| US20100224013A1 (en) | 2009-03-05 | 2010-09-09 | Van Berkel Gary J | Method and system for formation and withdrawal of a sample from a surface to be analyzed |
| EP2415067B1 (en) | 2009-04-01 | 2017-12-20 | Prosolia, Inc. | Method and system for surface sampling |
| US9500572B2 (en) | 2009-04-30 | 2016-11-22 | Purdue Research Foundation | Sample dispenser including an internal standard and methods of use thereof |
| US8704167B2 (en) | 2009-04-30 | 2014-04-22 | Purdue Research Foundation | Mass spectrometry analysis of microorganisms in samples |
| JP5671523B2 (ja) | 2009-04-30 | 2015-02-18 | パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 濡れた多孔質材料を用いるイオン生成 |
| KR101938742B1 (ko) | 2009-05-27 | 2019-01-15 | 마이크로매스 유케이 리미티드 | 생물 조직의 식별을 위한 시스템 및 방법 |
| WO2010141763A1 (en) | 2009-06-03 | 2010-12-09 | Wayne State University | Mass spectrometry using laserspray ionization |
| US8598521B2 (en) | 2009-08-17 | 2013-12-03 | Temple University Of The Commonwealth System Of Higher Education | Vaporization device and method for imaging mass spectrometry |
| US8546752B2 (en) * | 2009-12-07 | 2013-10-01 | Advion Inc. | Solid-phase extraction (SPE) tips and methods of use |
| AU2011214344A1 (en) | 2010-02-11 | 2012-08-16 | KATHOLIEKE UNIVERSITEIT LEUVEN, KULeuven R&D | Phospholipid profiling and cancer |
| WO2011127091A1 (en) | 2010-04-05 | 2011-10-13 | Indiana University Research And Technology Corporation | Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry |
| JP5596402B2 (ja) * | 2010-04-19 | 2014-09-24 | 株式会社日立ハイテクノロジーズ | 分析装置、イオン化装置及び分析方法 |
| US9063047B2 (en) * | 2010-05-07 | 2015-06-23 | Ut-Battelle, Llc | System and method for extracting a sample from a surface |
| CN201811941U (zh) * | 2010-05-26 | 2011-04-27 | 中国石油化工股份有限公司 | 液体样品解析电喷雾质谱desi-ms电离装置 |
| ES2812457T3 (es) | 2010-06-23 | 2021-03-17 | Univ Louisville Res Found Inc | Uso de ácidos grasos en procedimientos para detectar cáncer |
| US20130131470A1 (en) | 2010-07-14 | 2013-05-23 | The Regents of the University of Colorado, a body coporate | Methods and systems for in vivo clinical data measurement of analytes |
| US9153425B2 (en) * | 2010-09-01 | 2015-10-06 | Ut-Battelle, Llc | Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis |
| WO2012031082A2 (en) | 2010-09-02 | 2012-03-08 | University Of The Sciences In Philadelphia | System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry |
| US8486703B2 (en) * | 2010-09-30 | 2013-07-16 | Ut-Battelle, Llc | Surface sampling concentration and reaction probe |
| HUE055674T2 (hu) * | 2010-10-29 | 2021-12-28 | Thermo Fisher Scientific Oy | Rendszerelrendezés automatizált mintaelõkészítõ és -elemzõ rendszerhez |
| US10180426B2 (en) * | 2010-11-08 | 2019-01-15 | Dako Denmark A/S | Quantification of single target molecules in histological samples |
| CN102115741B (zh) * | 2010-12-10 | 2013-07-17 | 许汉鹏 | 一种原位分类提取生物大分子的方法及其系统 |
| CN102221614B (zh) * | 2011-03-28 | 2013-07-17 | 山东大学 | 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法 |
| US9157921B2 (en) | 2011-05-18 | 2015-10-13 | Purdue Research Foundation | Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging |
| US9546979B2 (en) | 2011-05-18 | 2017-01-17 | Purdue Research Foundation | Analyzing a metabolite level in a tissue sample using DESI |
| US9024254B2 (en) * | 2011-06-03 | 2015-05-05 | Purdue Research Foundation | Enclosed desorption electrospray ionization probes and method of use thereof |
| EP2798344B1 (en) | 2011-12-28 | 2023-12-13 | Micromass UK Limited | System and method for rapid evaporative ionization of liquid phase samples |
| US9305759B2 (en) | 2012-01-26 | 2016-04-05 | University Of The Sciences In Philadelphia | Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers |
| WO2013112836A2 (en) | 2012-01-26 | 2013-08-01 | The Cleveland Clinic Foundation | Diagnostic and prognostic biomarkers for cancer |
| JP5955032B2 (ja) * | 2012-03-01 | 2016-07-20 | キヤノン株式会社 | イオン化方法、質量分析方法、抽出方法及び精製方法 |
| US9105458B2 (en) | 2012-05-21 | 2015-08-11 | Sarah Trimpin | System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry |
| CN104603289A (zh) | 2012-06-15 | 2015-05-06 | 哈里·斯泰利 | 检测疾病或病状的方法 |
| WO2014045087A1 (en) | 2012-09-20 | 2014-03-27 | Oslo Universitetssykehus Hf | Prostate cancer markers and uses thereof |
| KR102174578B1 (ko) | 2012-11-27 | 2020-11-06 | 폰티피씨아 유니베르시다드 까똘리까 데 칠레 | 갑상선 종양을 진단하기 위한 조성물 및 방법 |
| WO2014106165A1 (en) | 2012-12-30 | 2014-07-03 | Brigham And Women's Hospital, Inc. | System and method for analysis of bio-metabolites for-use in image-guided surgery |
| US10983126B2 (en) | 2013-05-31 | 2021-04-20 | The Brigham And Women's Hospital | System and method for analyzing tissue for the presence of cancer using bio-marker profiles |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| FR3007634B1 (fr) | 2013-06-28 | 2016-09-02 | Commissariat Energie Atomique | Dispositif de prelevement in vivo d'especes biologiques et procede automatise d'analyse d'especes biologiques capturees au moyen d'un tel dispositif |
| EP3022762B1 (en) | 2013-07-19 | 2022-04-27 | Smiths Detection Inc. | Mass spectrometer inlet with reduced average flow |
| JP6323922B2 (ja) | 2013-08-07 | 2018-05-16 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析計供給源中への液体流れからの気泡除去 |
| US9245722B2 (en) * | 2013-09-16 | 2016-01-26 | Georgia Tech Research Corporation | SMS probe and SEM imaging system and methods of use |
| US20160341712A1 (en) | 2013-10-23 | 2016-11-24 | Brigham And Women's Hospital, Inc. | System and method for analyzing tissue intra-operatively using mass spectrometry |
| CN110648894B (zh) * | 2013-12-30 | 2022-05-13 | 普度研究基金会 | 用于电离样品的质谱分析探针和系统 |
| US20150202005A1 (en) | 2014-01-20 | 2015-07-23 | Omniguide, Inc. | System and Method To Control Surgical Energy Devices |
| JP2015171467A (ja) | 2014-03-12 | 2015-10-01 | セイコーエプソン株式会社 | 液体噴射装置および手術機器 |
| US9297828B2 (en) | 2014-03-27 | 2016-03-29 | Ut-Battelle, Llc | High heating rate thermal desorption for molecular surface sampling |
| US10000789B2 (en) | 2014-06-17 | 2018-06-19 | The Board Of Regents Of The University Of Oklahoma | Cellular probe device, system and analysis method |
| US9595428B2 (en) | 2014-06-17 | 2017-03-14 | The Board Of Regents Of The University Oklahoma | Cellular probe device, system and analysis method |
| US20160041138A1 (en) | 2014-08-11 | 2016-02-11 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for Monitoring Airborne Contaminants and Agents using Atmospheric Condensate |
| CA2978048A1 (en) * | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Liquid trap or separator for electrosurgical applications |
| KR101934663B1 (ko) | 2015-03-06 | 2019-01-02 | 마이크로매스 유케이 리미티드 | 급속 증발 이온화 질량 분광분석 (“reims”) 디바이스에 커플링된 이온 분석기용 유입구 기기장치 |
| US11342170B2 (en) * | 2015-03-06 | 2022-05-24 | Micromass Uk Limited | Collision surface for improved ionisation |
| US10026599B2 (en) | 2015-03-06 | 2018-07-17 | Micromass Uk Limited | Rapid evaporative ionisation mass spectrometry (“REIMS”) and desorption electrospray ionisation mass spectrometry (“DESI-MS”) analysis of swabs and biopsy samples |
| US11239066B2 (en) * | 2015-03-06 | 2022-02-01 | Micromass Uk Limited | Cell population analysis |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US10060838B2 (en) | 2015-04-09 | 2018-08-28 | Ut-Battelle, Llc | Capture probe |
| US9632066B2 (en) | 2015-04-09 | 2017-04-25 | Ut-Battelle, Llc | Open port sampling interface |
| EP3304033B1 (en) | 2015-05-29 | 2025-11-26 | Purdue Research Foundation | Methods for analyzing a tissue sample |
| GB201509402D0 (en) | 2015-06-01 | 2015-07-15 | Micromass Ltd | Lock mass library for internal correction |
| US11266383B2 (en) | 2015-09-22 | 2022-03-08 | University Health Network | System and method for optimized mass spectrometry analysis |
| US20170097355A1 (en) | 2015-10-06 | 2017-04-06 | University Of Washington | Biomarkers and methods to distinguish ovarian cancer from benign tumors |
| GB2548596A (en) | 2016-03-22 | 2017-09-27 | Micromass Ltd | An interface probe |
| WO2018013678A2 (en) | 2016-07-13 | 2018-01-18 | Board Of Regents, The University Of Texas System | Molecular markers and methods for sample analysis via mass spectrometry |
| EP4357784A3 (en) | 2016-09-02 | 2024-07-31 | Board of Regents, The University of Texas System | Collection probe and methods for the use thereof |
| WO2018045208A1 (en) | 2016-09-02 | 2018-03-08 | Board Of Regents, The University Of Texas System | Collection probe and methods for the use thereof |
| US10492801B2 (en) | 2016-09-20 | 2019-12-03 | Osteomed Llc | Power driven surgical tool |
| MX2020005448A (es) | 2017-11-27 | 2020-08-27 | Univ Texas | Sonda de recoleccion minimamente invasiva y metodos para el uso de esta. |
| EP3756014B1 (en) | 2018-02-23 | 2025-12-24 | Board of Regents, The University of Texas System | Tissue analysis by mass spectrometry |
-
2017
- 2017-08-31 EP EP23220654.0A patent/EP4357784A3/en active Pending
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