CN113827635A - Traditional Chinese medicine composition for relaxing bowels and preparation method thereof - Google Patents

Traditional Chinese medicine composition for relaxing bowels and preparation method thereof Download PDF

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CN113827635A
CN113827635A CN202111016483.0A CN202111016483A CN113827635A CN 113827635 A CN113827635 A CN 113827635A CN 202111016483 A CN202111016483 A CN 202111016483A CN 113827635 A CN113827635 A CN 113827635A
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赵井文
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Abstract

The invention provides a traditional Chinese medicine composition for relaxing bowels and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The laxative traditional Chinese medicine composition is prepared from the components in a reasonable relation and has a specific proportion, and the laxative traditional Chinese medicine composition is beneficial to clearing intestines and defecating, improving intestinal tracts and promoting gastrointestinal peristalsis. The radish and the Chinese cabbage are in a ratio of 1:5, so that the composition can relieve food retention, eliminate phlegm and heat, clear heat and remove toxicity while relaxing intestines and stomach, and has a health-care effect while treating constipation. Meanwhile, the radish and the Chinese cabbage serving as common fruit and vegetable products are easy to obtain, low in cost and beneficial to mass production, and the homology of medicine and food is also beneficial to acceptance of users and popularization of manufacturers. Therefore, the composition has the advantages of low cost, contribution to mass production, contribution to user acceptance and contribution to popularization of manufacturers.

Description

Traditional Chinese medicine composition for relaxing bowels and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for relaxing bowels and a preparation method thereof.
Background
Constipation means that the defecation frequency is reduced, and meanwhile, the defecation is difficult and the feces are dry and hard. The common constipation causes and the prevalence rate of the constipation of the elderly related to the age are obviously increased compared with the elderly in the middle-aged, mainly because the food intake and physical activity of the elderly are obviously reduced along with the age, the secretion of digestive juice of gastrointestinal tracts is reduced, the tension and the peristalsis of intestinal tracts are weakened, muscles of abdominal cavities and pelvic floors are weakened, internal and external sphincters of anus are weakened, the reflection of stomach and colon is weakened, the sensitivity of rectum is reduced, food stays in the intestines for a long time, and the excessive absorption of water causes the constipation. In addition, elderly people often lose the defecation reflex due to senile dementia or dysthymia, causing constipation. Meanwhile, bad living habits are also one of the common causes. The old people have teeth falling off, are fond of eating low-residue fine food, or are convenient and trouble-saving for a few patients, have simple diet and lack of coarse fibers, so that the volume of excrement is reduced, the viscosity is increased, the movement in the intestines is slowed down, and the excessive absorption of water causes constipation. In addition, the elderly may also suffer constipation due to poor food intake, low caloric content of the food, and slow gastrointestinal transit time. Reduced activity due to certain disease and obesity factors, particularly in bedridden or wheelchair patients, is also prone to constipation due to lack of motor stimulation to propel fecal movements.
At present, health care products adopted for conditioning intestinal problems such as constipation are single in component, poor in compatibility effect, free of medicine and food homology effect and incapable of being prepared into various types of compositions.
Disclosure of Invention
The invention aims to provide a laxative traditional Chinese medicine composition which is homologous in medicine and food and has the functions of clearing intestines and relieving constipation, improving intestinal tracts and promoting gastrointestinal peristalsis.
The invention also aims to provide a preparation method of the laxative traditional Chinese medicine composition, which is prepared into viscous liquid by applying the modern pharmaceutical technical method, and the viscous liquid is beneficial to subsequent production, can be prepared into pills, tablets or gels and is beneficial to different types of patients to use.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a laxative traditional Chinese medicine composition which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of radish, 25-75 parts of Chinese cabbage, 5-15 parts of black fungus, 10-30 parts of basil, 10-30 parts of kelp, 5-15 parts of crowndaisy chrysanthemum, 5-15 parts of bean sprouts, 3-10 parts of chicken's gizzard-membrane, 1-3 parts of pine nuts, 10-30 parts of fructus cannabis, 50-100 parts of radish plant ash and 20-60 parts of honey.
In another aspect, the present application provides a preparation method for treating gout, including the following steps:
weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of a first component;
weighing radish and Chinese cabbage, adding water, boiling into viscous liquid, crushing and sieving endothelium corneum gigeriae galli to obtain endothelium corneum gigeriae galli particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the endothelium corneum gigeriae galli particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water for boiling;
and (3) putting the powder particles of the first component into the viscous liquid while stirring to obtain the mixed viscous liquid.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the Chinese radish, the woad, the black fungus, the basil, the kelp, the crowndaisy chrysanthemum, the bean sprouts, the endothelium corneum gigeriae galli, the pine nuts, the fructus cannabis, the radish plant ash and the honey provided by the invention are used as essential medicines for treating constipation, the raw material cost is low, the source is wide, the price of the formula is greatly reduced, and the Chinese radish tea has great benefits for patients with economic difficulties.
The Chinese medicinal composition for relaxing the bowels has the advantages of simple and reasonable formula, low cost, good curative effect, no toxic or side effect and the like. The radish and the Chinese cabbage are in a ratio of 1:5, so that the composition can relieve food retention, eliminate phlegm and heat, clear heat and remove toxicity while relaxing intestines and stomach, and has a health-care effect while treating constipation. Meanwhile, the radish and the Chinese cabbage serving as common fruit and vegetable products are easy to obtain, low in cost and beneficial to mass production, and the homology of medicine and food is also beneficial to acceptance of users and popularization of manufacturers. Therefore, the composition has the effects of low cost, contribution to large-scale production, contribution to user acceptance and contribution to popularization of manufacturers.
The preparation method provided by the invention has the advantages that each substance in the raw materials is divided into the first component and the second component to be respectively processed, so that mutual interference among the raw materials is avoided, the drug effect is favorably exerted, meanwhile, the viscous liquid can be prepared, and a manufacturer can conveniently prepare pills, tablets or gels according to specific use requirements, so that the product can be specifically prepared, the applicability to crowds is improved (for example, children are more suitable for placing the gels into drinks, old people are more suitable for the pills, the taking is convenient, middle-aged people are more suitable for the tablets, and the carrying is convenient), and the compliance of taking the medicine by patients is further favorably improved.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
On one hand, the embodiment of the application provides a laxative traditional Chinese medicine composition which is mainly prepared from the following raw materials in parts by weight: 5-15 parts of radish, 25-75 parts of Chinese cabbage, 5-15 parts of black fungus, 10-30 parts of basil, 10-30 parts of kelp, 5-15 parts of crowndaisy chrysanthemum, 5-15 parts of bean sprouts, 3-10 parts of chicken's gizzard-membrane, 1-3 parts of pine nuts, 10-30 parts of fructus cannabis, 50-100 parts of radish plant ash and 20-60 parts of honey.
In some embodiments of the invention, the composition is mainly prepared from the following raw materials in parts by weight: 10 parts of radish, 50 parts of Chinese cabbage, 10 parts of black fungus, 20 parts of basil, 20 parts of kelp, 10 parts of crowndaisy chrysanthemum, 10 parts of bean sprouts, 7 parts of chicken's gizzard-membrane, 2 parts of pine nuts, 20 parts of fructus cannabis, 80 parts of radish plant ash and 40 parts of honey.
In some embodiments of the invention, the composition comprises 5 parts of radish, 25 parts of Chinese cabbage, 5 parts of black fungus, 10 parts of basil, 10 parts of kelp, 5 parts of crowndaisy chrysanthemum, 5 parts of bean sprouts, 6 parts of chicken's gizzard-membrane, 2 parts of pine nut, 24 parts of fructus cannabis, 50 parts of radish plant ash and 30 parts of honey.
Radish, also called radish and luo fu. Pungent and sweet in nature and cool in nature. Resolving food stagnation, resolving phlegm-heat, descending qi, relieving epigastric distention and removing toxicity. It is indicated for food stagnation, fullness and distention, cough with phlegm, aphonia, hematemesis, epistaxis, diabetes, dysentery, migraine and headache.
Isatis tinctoria, Chinese cabbage, Chinese medicine name. Is leaf of Brassica chinensis L.of Brassicaceae. Sweet in nature and taste, cool in nature. It enters lung, stomach and large intestine meridians. Relieving fever and relieving restlessness, promoting the production of body fluid to quench thirst, clearing lung-heat and eliminating phlegm, and smoothing intestines and stomach. Can be used for treating cough due to lung heat, diabetes, constipation, food stagnation, erysipelas, and skin ulcer.
The black fungus, also called as Auricularia and Morus alba Linne, is the fruiting body of Auricularia auricular (L.) Underw. Sweet in nature and taste, neutral in nature. It enters lung, spleen, large intestine and liver meridians. Invigorating qi, nourishing blood, moistening lung, stopping bleeding, lowering blood pressure, and resisting cancer. Can be used for treating qi deficiency and blood deficiency, tetany of extremities, chronic cough due to lung deficiency, hemoptysis, hematemesis, epistaxis, bloody flux, hemorrhoid hemorrhage, metrorrhagia, hypertension, constipation, eyeground hemorrhage, cervical cancer of subsidiary organs, vaginal cancer, and traumatic injury.
Ocimum basilicum, a plant of Ocimum of Labiatae and Labiatae, is a dual-purpose aromatic plant used as medicine and food, and has the functions of dispelling wind, promoting qi circulation, eliminating dampness, promoting digestion, promoting blood circulation and removing toxicity. Can be used for treating headache due to exogenous pathogenic factors, food stagnation, abdominal pain, diarrhea, menoxenia, traumatic injury, snake and insect bite, skin eczema, urticaria, pain, and pruritus.
Kelp (Laminaria japonica), a perennial large edible alga [1 ]. Sporophytes are large, brown, flat, ribbon-like. The blade, the handle and the fixer are divided, and the fixer is in a false root shape. The cellulose contained in the kelp can remove the metabolic waste in the digestive tract in time and prevent the problems of constipation, intestinal cancer and the like. In addition, the kelp also has the effects of softening and resolving hard mass and inducing diuresis, so that the problems of cardiovascular and cerebrovascular diseases such as hypertension, hyperglycemia and the like can be effectively prevented.
Chrysanthemum coronarium L, also known as Artemisia annua, Artemisia capillaris, Artemisia arvensis, Chrysanthemum morifolium, Artemisia japonica, Artemisia rod, Artemisia annua, Chrysanthemum indicum, Tung Hua vegetable, and Tung Hua vegetable (also called goose vegetable and Yi vegetable in Fujian, etc.), is an annual or biennial herb of Campanulales, Compositae, Chrysanthemum coronarium. Sweet, pungent and mild in nature and taste, has no toxicity, and has the effects of calming heart-qi, nourishing spleen and stomach, eliminating phlegm and retained fluid and benefiting intestines and stomach.
The bean sprouts, also called sprouting vegetables and smart sprouts, comprise mung bean sprouts and soybean sprouts so that the defecation effect of the mung bean sprouts is better. The mung bean sprouts have the effects of nourishing yin, clearing heat, removing dampness and detoxifying, and can effectively improve the problem of lung heat and intestinal dryness by frequent eating of the mung bean sprouts, so that the dry and hard stool condition is relieved, and the discharge of toxins in the body is facilitated.
Endothelium corneum Gigeriae Galli is the inner wall of dry sand sac of Garlus grandis family chicken Brisson of Phasianidae. Sweet in nature and mild in nature. It enters spleen, stomach, small intestine and bladder meridians. Strengthening the stomach to promote digestion, arresting seminal emission and relieving enuresis, and treating stranguria and removing calculus. Can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with stone, pain, gallbladder distention, and hypochondriac pain.
Pine nuts, also known as pine nuts, and sea pine nuts, are seeds of Pinaceae plants, such as Pinus koraiensis. Has effects of moistening lung, relieving cough, smoothing intestine, relaxing bowels, eliminating arthralgia, and caring skin and hair.
Fructus Cannabis. Sweet in nature and mild in nature. It enters spleen, stomach and large intestine meridians. To moisten intestines and relax bowels. Can be used for treating constipation due to intestinal dryness and blood deficiency.
The honey is prepared from Apis cerana Fabricius or Apis mellifera Linnaeus. Sweet and neutral. It enters lung, spleen and large intestine meridians. Tonify middle energizer, moisten dryness, alleviate pain, remove toxicity; promoting tissue regeneration and healing wound for external use. Can be used for treating abdominal pain, dry cough due to lung dryness, constipation due to intestinal dryness, and headache due to wind-cold-dampness; it is indicated for sores and ulcers, scald due to hot water or fire.
On the other hand, the embodiment of the application provides a preparation method of the laxative traditional Chinese medicine composition, which comprises the following steps: weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of a first component;
weighing radish and Chinese cabbage, adding water, boiling into viscous liquid, crushing and sieving endothelium corneum gigeriae galli to obtain endothelium corneum gigeriae galli particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the endothelium corneum gigeriae galli particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water for boiling;
and (3) putting the powder particles of the first component into the viscous liquid while stirring to obtain the mixed viscous liquid.
The preparation method has the advantages that the viscous liquid can be prepared, so that the thick liquid can be conveniently made into pills, tablets or gels according to specific use requirements, the product can be specifically made, the applicability to people is improved (for example, children are more suitable for placing the gels into drinks, old people are more suitable for pills, the taking is convenient, middle-aged people are more suitable for tablets, and the carrying is convenient), and the compliance of taking medicines by patients is improved.
In some embodiments of the invention, in the microwave extraction, the microwave frequency is 100Hz and the microwave power is 1000W.
In some embodiments of the present invention, the specific method is that in the step of weighing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts, freeze-drying and grinding the weighed materials to obtain the powder particles of the first component;
uniformly mixing materials of the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, melting the materials into 500 portions of purified water of 300 portions, simultaneously carrying out ultrasonic treatment to uniformly distribute the components in the solution to obtain a mixed solution, spraying the mixed solution under the condition of flow rate of 3-10 mL/min, directly feeding the obtained fogdrop into liquid nitrogen for solidification, collecting the fogdrop to a freezing chamber through a vacuumizing device, putting the fogdrop into the freezing chamber, and freezing to obtain powder particles of the first component.
The ultrasonic treatment controls the ultrasonic power of more than 10kHz to be 10-300W and the ultrasonic time to be 1-2 h, so that the loss of volatile components and heat-denatured nutrient components and aromatic components in the raw materials can be reduced, and simultaneously, after low-temperature drying, 95-99.5% of moisture in the raw materials can be removed, and the storage period is long; drying at low temperature can not denature protein and enzyme, but can make microorganism lose biological activity, thereby facilitating subsequent processing production and improving drug effect.
In some embodiments of the present invention, the radish plant ash is added to the mixed viscous liquid, and after sufficient and uniform stirring, a dough-like composition is obtained, and then the honey is added to the dough-like composition, and the pills are formed by rolling to obtain the pills.
Compared with gel and tablet, the pill is suitable for the elderly, and has wide application range.
In some embodiments of the present invention, the radish plant ash is added to the mixed viscous liquid, and after sufficient stirring to obtain a dough-like composition, the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 0.1-5% of the weight of the dough-like composition are added to the dough-like composition, and the mixture is uniformly pressed to obtain a tablet.
The lactitol, the microcrystalline cellulose and the magnesium stearate are beneficial to tabletting and forming, and the formed tablets are convenient to carry and convenient to use by adults in the fast pace of modern life.
In some embodiments of the present invention, a gel matrix is added to the mixed viscous liquid, and after mixing and stirring, the gel matrix is solidified to obtain a gel.
The gel can be added into beverage for soaking and taking, and has effects of improving taste, improving palatability of the composition, and facilitating children's administration.
In some embodiments of the present invention, the gel matrix is added to the mixed viscous liquid, and after mixing and stirring, the gel is obtained by curing:
the curing method is heating curing, wherein the heating curing mode is heating to 50-90 ℃, keeping the temperature for 0.2-2h, and then cooling to 0-20 ℃.
Compared with ultrasonic curing, the curing mode has the advantages of lower cost, contribution to production and cost reduction.
In some embodiments of the invention, the gel matrix is gelatin, xanthan gum, or carbomer.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes: 5g of radish, 25g of Chinese cabbage, 5g of black fungus, 10g of basil, 10g of kelp, 5g of crowndaisy chrysanthemum, 5g of bean sprouts, 3g of chicken's gizzard-membrane, 1g of pine nut, 10g of fructus cannabis, 50g of radish plant ash and 20g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
s4, adding the radish plant ash into the mixed viscous liquid, fully and uniformly stirring to obtain a dough-shaped composition, adding the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 0.1% of the weight of the dough-shaped composition into the dough-shaped composition, uniformly mixing and tabletting to obtain the tabletting.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 300 parts of purified water, ultrasonic treatment is simultaneously performed to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of a flow rate of 3mL/min, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected by a vacuumizing device to a freezing chamber, and the droplets are placed into the freezing chamber to obtain powder particles of the first component after freezing.
Auricularia is known as intestinal tract cleaning husband, and has the functions of nourishing yin, moistening dryness, promoting blood circulation, stopping bleeding, and loosening bowel to relieve constipation. Not only can inhibit inflammation of digestive tract, but also can effectively improve constipation. It contains enzymes and alkaloids, and can promote secretion of digestive juice to lubricate intestinal tract. The black fungus is a tonic with high nutritive value, has the effects of nourishing yin, moistening lung, tonifying qi, clearing intestine, promoting fluid production, moistening dryness, and can not only improve the problems of cough, thirst, fatigue and the like, but also effectively improve the intestinal function. Tremella contains large amount of dietary fiber, and has effects of promoting intestinal tract movement, inhibiting fat absorption, and preventing constipation. The bean sprout has effects of nourishing yin, clearing heat, eliminating dampness and removing toxic substance, and can effectively improve dryness of lung heat and intestine by eating mung bean sprout frequently, so as to relieve constipation, and is helpful for discharging toxin in vivo. The cellulose contained in the sea tangle can remove the metabolic waste in the digestive tract in time, and prevent constipation and intestinal cancer. The crowndaisy chrysanthemum has the effects of nourishing heart and spleen and benefiting intestines and stomach, and the habitual constipation, dyspepsia and other problems can be effectively prevented and treated by eating the crowndaisy chrysanthemum frequently. The volatile substances in the crowndaisy chrysanthemum can promote the secretion of digestive glands, enhance appetite and promote digestion, and the abundant cellulose contained in the crowndaisy chrysanthemum is beneficial to discharging intestinal toxins and improving the problems of constipation, obesity and the like.
Example 2
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes: 15g of radish, 75g of woad, 15g of black fungus, 30g of basil, 30g of kelp, 15g of crowndaisy chrysanthemum, 15g of bean sprouts, 10g of chicken's gizzard-membrane, 3g of pine nuts, 30g of fructus cannabis, 100g of radish plant ash and 60g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
and S4, adding the radish plant ash into the mixed viscous liquid, fully and uniformly stirring to obtain a dough-shaped composition, adding the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 5% of the weight of the dough-shaped composition into the dough-shaped composition, uniformly mixing and tabletting to obtain the tabletting.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 500 parts of purified water, ultrasonic treatment is simultaneously performed to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of 10mL/min of flow, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected to a freezing chamber through a vacuum extractor, and the droplets are placed into the freezing chamber to obtain powder particles of the first component after freezing.
Example 3
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes: 10g of radish, 50g of woad, 10g of black fungus, 20g of basil, 20g of kelp, 10g of crowndaisy chrysanthemum, 10g of bean sprouts, 7 g of chicken's gizzard-membrane, 2g of pine nuts, 20g of fructus cannabis, 80g of radish plant ash and 40g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
and S4, adding the radish plant ash into the mixed viscous liquid, fully and uniformly stirring to obtain a dough-shaped composition, adding the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 2% of the weight of the dough-shaped composition into the dough-shaped composition, uniformly mixing and tabletting to obtain the tabletting.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 400 parts of purified water, ultrasonic treatment is simultaneously carried out to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of 5mL/min of flow, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected to a freezing chamber through a vacuumizing device and then are placed into the freezing chamber, and the powder particles of the first component are obtained after freezing.
Example 4
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes:
5g of radish, 25g of Chinese cabbage, 5g of black fungus, 10g of basil, 10g of kelp, 5g of crowndaisy chrysanthemum, 5g of bean sprouts, 6g of chicken's gizzard-membrane, 2g of pine nuts, 24g of fructus cannabis, 50g of radish plant ash and 30g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
s4, adding the radish plant ash into the mixed viscous liquid, fully and uniformly stirring to obtain a dough-shaped composition, adding the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 2.5% of the weight of the dough-shaped composition into the dough-shaped composition, uniformly mixing and tabletting to obtain the tabletting.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 400 parts of purified water, ultrasonic treatment is simultaneously carried out to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of 5mL/min of flow, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected to a freezing chamber through a vacuumizing device and then are placed into the freezing chamber, and the powder particles of the first component are obtained after freezing.
Example 5
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes: 5g of radish, 25g of Chinese cabbage, 5g of black fungus, 10g of basil, 10g of kelp, 5g of crowndaisy chrysanthemum, 5g of bean sprouts, 6g of chicken's gizzard-membrane, 2g of pine nuts, 24g of fructus cannabis, 50g of radish plant ash and 30g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
s4, adding the radish plant ash into the mixed viscous liquid, fully and uniformly stirring to obtain a dough-shaped composition, adding the honey into the dough-shaped composition, and kneading to obtain the pill.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 400 parts of purified water, ultrasonic treatment is simultaneously carried out to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of 5mL/min of flow, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected to a freezing chamber through a vacuumizing device and then are placed into the freezing chamber, and the powder particles of the first component are obtained after freezing.
Compared with gel and tablet, the pill is suitable for the elderly, and has wide application range.
Example 6
The present embodiment aims to provide a laxative traditional Chinese medicine composition, which includes: 5g of radish, 25g of Chinese cabbage, 5g of black fungus, 10g of basil, 10g of kelp, 5g of crowndaisy chrysanthemum, 5g of bean sprouts, 6g of chicken's gizzard-membrane, 2g of pine nuts, 24g of fructus cannabis, 50g of radish plant ash and 30g of honey.
The laxative traditional Chinese medicine composition provided by the embodiment can be prepared by the following steps:
s1, weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of the first component;
s2, weighing radish and Chinese cabbage, adding water to boil into viscous liquid, crushing chicken ' S gizzard-membrane, sieving to obtain chicken ' S gizzard-membrane particles, frying pine nuts and fructus cannabis, crushing to obtain mixed particles, mixing the chicken ' S gizzard-membrane particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil;
s3, putting the powder particles of the first component into the viscous liquid while stirring to obtain mixed viscous liquid;
and S4, adding a gel matrix into the mixed viscous liquid, mixing and stirring, and curing to obtain the gel.
In step S4, the curing method is heating curing, wherein the heating curing is performed by heating to 50-90 ℃, keeping the temperature for 0.2-2h, and then cooling to 0-20 ℃. The gel matrix is gelatin, xanthan gum or carbomer.
In step S3, the material obtained by uniformly mixing the black fungus, the basil, the kelp, the garland chrysanthemum and the bean sprouts is melted into 400 parts of purified water, ultrasonic treatment is simultaneously carried out to uniformly distribute the components in the solution to obtain a mixed solution, then the mixed solution is sprayed under the condition of 5mL/min of flow, the obtained droplets directly enter liquid nitrogen for solidification, the droplets are collected to a freezing chamber through a vacuumizing device and then are placed into the freezing chamber, and the powder particles of the first component are obtained after freezing.
Examples of effects
90 volunteers of constipation patients are collected, wherein 49 men and 41 women have the disease course of 7-14 days and are divided into 6 groups, each group comprises 15 patients, pills, tablets and gels with the same drug effect content are regularly and quantitatively taken, and the effective rate and the cure rate are shown in the following table. Statistical analysis of gender revealed that the difference between them was not statistically significant (P > 0.05). The screening conditions for constipation patients were as follows:
1) the number of defecations per week is less than 3, and the constipation symptom is regarded as mild;
2) the single bowel movement period is 2-4 weeks, and constipation symptoms are considered severe.
Before treatment and 7 days after treatment, follow-up observation is carried out, and symptoms, sign changes and adverse reactions are recorded at each follow-up visit.
Figure BDA0003240015870000161
Therefore, the tableted composition of example 4 was most effective in use, and the effective rate and cure rate were higher for 7 days and 14 days than for the other examples.
In case one, Zhu Yi, 43 years old, male, chronic constipation, manifested as dry stool, abdominal distension and pain, insomnia and restlessness. The composition prepared as described in example 4 was consumed by introduction to friends. The application method comprises taking the tablet twice daily, and taking two tablets once. After continuous use for 30 days, the constipation symptom basically disappears, the defecation is smooth, and the abdominal pain symptom disappears.
In case two, Gong Yi, 73 years old, male with chronic constipation, manifested as less stool, difficult defecation, and mild abdominal pain. The composition prepared as described in example 5 was consumed. The application method comprises taking 10 pills twice daily with water. After the continuous use for 25 days, the constipation symptom basically disappears, the defecation is smooth, and the abdominal pain symptom disappears.
In conclusion, the laxative traditional Chinese medicine composition provided by the invention is prepared from the components in a reasonable relationship and has a specific proportion, and the laxative traditional Chinese medicine composition is beneficial to clearing intestines and discharging feces, improving intestinal tracts and promoting gastrointestinal peristalsis. The radish and the Chinese cabbage are in a ratio of 1:5, so that the composition can relieve food retention, eliminate phlegm heat, clear away heat and toxic materials while relaxing intestines and stomach, and can achieve a health-care effect while treating constipation. Meanwhile, the radish and the Chinese cabbage are used as common fruit and vegetable products, are easy to obtain, have low cost, are beneficial to mass production, and are also beneficial to acceptance of users and popularization of manufacturers due to homology of medicine and food. Therefore, the composition has the advantages of low cost, contribution to mass production, contribution to user acceptance and contribution to popularization of manufacturers.
According to the preparation method provided by the invention, each substance in the raw materials is divided into the first component and the second component to be respectively processed, so that mutual interference among the raw materials is avoided, the drug effect is favorably exerted, meanwhile, the viscous liquid can be prepared, and a manufacturer can conveniently prepare pills, tablets or gel according to specific use requirements, so that the product can be specifically prepared, the applicability to people is improved (for example, children are more suitable for placing gel into drinks, old people are more suitable for pills, the taking is convenient, middle-aged people are more suitable for tabletting, and the carrying is convenient), and further the medicine taking compliance of patients is favorably improved.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The traditional Chinese medicine composition for relaxing bowels is characterized by being mainly prepared from the following raw materials in parts by weight: 5-15 parts of radish, 25-75 parts of Chinese cabbage, 5-15 parts of black fungus, 10-30 parts of basil, 10-30 parts of kelp, 5-15 parts of crowndaisy chrysanthemum, 5-15 parts of bean sprouts, 3-10 parts of chicken's gizzard-membrane, 1-3 parts of pine nuts, 10-30 parts of fructus cannabis, 50-100 parts of radish plant ash and 20-60 parts of honey.
2. The laxative traditional Chinese medicine composition according to claim 1, which is mainly prepared from the following raw materials in parts by weight: 10 parts of radish, 50 parts of Chinese cabbage, 10 parts of black fungus, 20 parts of basil, 20 parts of kelp, 10 parts of crowndaisy chrysanthemum, 10 parts of bean sprouts, 7 parts of chicken's gizzard-membrane, 2 parts of pine nuts, 20 parts of fructus cannabis, 80 parts of radish plant ash and 40 parts of honey.
3. The laxative traditional Chinese medicine composition according to claim 1, which is mainly prepared from the following raw materials in parts by weight: 5 parts of radish, 25 parts of Chinese cabbage, 5 parts of black fungus, 10 parts of basil, 10 parts of kelp, 5 parts of crowndaisy chrysanthemum, 5 parts of bean sprouts, 6 parts of chicken's gizzard-membrane, 2 parts of pine nuts, 24 parts of fructus cannabis, 50 parts of radish plant ash and 30 parts of honey.
4. A method for preparing a laxative traditional Chinese medicine composition according to any one of claims 1 to 3, comprising the following steps:
weighing the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, and freeze-drying to obtain powder particles of a first component;
weighing radish and Chinese cabbage, adding water to boil the radish and Chinese cabbage into viscous liquid, crushing and sieving endothelium corneum gigeriae galli to obtain endothelium corneum gigeriae galli particles, frying pine nuts and fructus cannabis, crushing the fried pine nuts and fructus cannabis to obtain mixed particles, mixing the endothelium corneum gigeriae galli particles with the mixed particles to obtain powder particles of a second component, putting the mixed particles into the viscous liquid, and adding water to boil the mixture;
and (3) putting the powder particles of the first component into the viscous liquid while stirring to obtain the mixed viscous liquid.
5. The method according to claim 4, wherein the step of weighing the black fungus, basil, kelp, garland chrysanthemum and bean sprouts, freeze-drying and grinding to obtain the powder particles of the first component comprises;
uniformly mixing materials of the black fungus, the basil, the kelp, the crowndaisy chrysanthemum and the bean sprouts, melting the materials into 500 portions of purified water of 300 portions, simultaneously carrying out ultrasonic treatment to uniformly distribute the components in the solution to obtain a mixed solution, spraying the mixed solution under the condition of flow rate of 3-10 mL/min, directly feeding the obtained fogdrop into liquid nitrogen for solidification, collecting the fogdrop to a freezing chamber through a vacuumizing device, putting the fogdrop into the freezing chamber, and freezing to obtain powder particles of the first component.
6. The preparation method according to claim 4, wherein the radish plant ash is added to the mixed viscous liquid, the mixture is fully and uniformly stirred to obtain a dough-like composition, and then the honey is added to the dough-like composition to obtain the pill.
7. The preparation method according to claim 6, wherein the radish plant ash is added to the mixed viscous liquid, the mixture is fully stirred to obtain a dough-like composition, and then the lactitol, the microcrystalline cellulose and the magnesium stearate accounting for 0.1-5% of the weight of the dough-like composition are added to the dough-like composition, and the mixture is uniformly mixed and tabletted to obtain the tablet.
8. The method according to claim 6, wherein a gel matrix is added to the mixed viscous liquid, and after mixing and stirring, the gel matrix is solidified to obtain the gel.
9. The method according to claim 8, wherein the step of adding the gel matrix to the mixed viscous liquid, mixing and stirring, and curing to obtain the gel is a step of:
the curing method is heating curing, wherein the heating curing mode is heating to 50-90 ℃, keeping the temperature for 0.2-2h, and then cooling to 0-20 ℃.
10. The method of claim 8 or 9, wherein the gel matrix is gelatin, xanthan gum or carbomer.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1561807A (en) * 2004-04-15 2005-01-12 童良坤 Instant vegetable food and its preparing method
CN104983886A (en) * 2015-07-29 2015-10-21 张光泉 Traditional Chinese medicine preparation for treating constipation and preparing method thereof
CN104984141A (en) * 2015-07-29 2015-10-21 张光泉 Prescription for treating constipation and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1561807A (en) * 2004-04-15 2005-01-12 童良坤 Instant vegetable food and its preparing method
CN104983886A (en) * 2015-07-29 2015-10-21 张光泉 Traditional Chinese medicine preparation for treating constipation and preparing method thereof
CN104984141A (en) * 2015-07-29 2015-10-21 张光泉 Prescription for treating constipation and preparation method thereof

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