CN108542946B - Traditional Chinese medicine prescription with weight-losing function and preparation method thereof - Google Patents
Traditional Chinese medicine prescription with weight-losing function and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine pharmaceutics, in particular to a traditional Chinese medicine prescription with a weight-losing function and a preparation method and application thereof. The invention provides a traditional Chinese medicine preparation with a weight-losing function, which comprises the following raw materials in parts by weight: 25-30 parts of pseudo-ginseng, 15-20 parts of burdock, 15-20 parts of cassia seed, 10-15 parts of astragalus membranaceus, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of poria cocos, 5-10 parts of lotus leaf, 5-10 parts of selfheal, 3-6 parts of fructus cannabis and 3-6 parts of bunge cherry seed. The Chinese herbal medicine composition takes the Chinese herbal medicines as main raw materials, not only can reduce weight, but also has the special health-care effects of strengthening spleen and stomach, preventing constipation, decomposing blood cholesterol and the like.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine pharmaceutics, in particular to a traditional Chinese medicine prescription with a weight-losing function and a preparation method and application thereof.
Background
Obesity, which is a common risk factor for cardiovascular diseases, type 2 diabetes, hypertension, hyperlipidemia, malignant tumors and other chronic diseases, not only increases the morbidity and mortality of the chronic diseases, but also increases the burden of the global health and medical system. In recent years, with the pace of people's life and work accelerating, and the obvious shortages of lifestyle changes, poor eating habits and physical exercise amount, obesity has become increasingly prevalent worldwide, especially in developing countries where the economy has rapidly increased. According to incomplete statistics, the direct economic burden of people in China in 2003 caused by relevant diseases such as hypertension, diabetes, coronary heart disease, cerebral apoplexy and the like caused by overweight and obesity accounts for 3.2 percent and 3.7 percent of the total cost of the Chinese health and the total medical cost in the year, and the economic burden of people in Europe and America accounts for 2 percent to 7 percent. In recent years, many epidemiological studies show that the distribution of fat in vivo, particularly abdominal fat accumulation, is more closely related to diabetes and cardiovascular diseases, and central obesity has higher value in predicting cardiovascular diseases and medical burden. Unlike euros, asians are more prone to accumulation of abdominal fat, even in normal weight populations with the risk factors of central obesity, which has become a public health problem that requires more extensive attention than simple weight gain, and cardiovascular and cerebrovascular disease. Over the past decade, overweight and central obesity in china have both shown a significant increase in the trend.
The middle-aged and the elderly and the teenagers are more and more obese, which not only affects the body beauty of people, but also potentially induces other diseases, so that early prevention and treatment are needed. The existing weight-losing medicines with different shapes and colors are mainly chemical synthesis or semi-synthesis medicines, the action mechanism of the medicine is mostly to achieve the purpose of losing weight by controlling diet and increasing excretion function, such as amphetamines and biguanide medicines, have large physical consumption and strong side effect, and have high rebound rate after medicine withdrawal, while the traditional Chinese medicine weight-losing medicine is favored by patients due to definite curative effect, simultaneous treatment of principal and subordinate symptoms and small side effect.
The pathological understanding of obesity in traditional Chinese medicine is mainly 'excessive phlegm' and 'less qi', the pathogenesis of the obesity is insufficiency of qi of spleen, lung and kidney, qi, blood and body fluid cannot be distributed, and dampness is easy to accumulate to generate phlegm. Obesity is mostly due to deficiency of the essence and excess of the essence, wherein spleen deficiency, kidney deficiency and stagnation of liver qi are the main symptoms, and phlegm, dampness, heat and blood stasis are the main symptoms. Namely, the disorder of the liver and gallbladder, which is caused by the deficiency of spleen and kidney qi, causes the retention of grease and water dampness, the disorder of qi movement and the unfavorable pulse channel. In therapeutic treatment, the spleen and kidney are regulated and regulated, and the actions of resolving dampness, promoting diuresis, dredging collaterals, strengthening spleen, warming yang and the like are combined. Clinically, obesity is mostly caused by spleen deficiency and dampness obstruction and stomach heat and dampness obstruction, wherein people with frequent spleen deficiency and dampness obstruction are middle-aged and elderly obesity patients, and people with frequent stomach heat and dampness obstruction are teenager patients.
In conclusion, the development of a weight-losing traditional Chinese medicine preparation which is pure natural, free of additives, free of toxic and side effects and strong in pertinence is particularly important for meeting the requirements of consumers.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a traditional Chinese medicine preparation with the function of losing weight and a preparation method thereof; the Chinese herbal medicine composition takes the Chinese herbal medicines as main raw materials, not only can reduce weight, but also has the special health-care effects of strengthening spleen and stomach, preventing constipation, decomposing blood cholesterol and the like.
In order to achieve the purpose, the invention provides a traditional Chinese medicine preparation with a weight-losing function, which comprises the following raw materials in parts by weight: 25-30 parts of pseudo-ginseng, 15-20 parts of burdock, 15-20 parts of cassia seed, 10-15 parts of astragalus membranaceus, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of poria cocos, 5-10 parts of lotus leaf, 5-10 parts of selfheal, 3-6 parts of fructus cannabis and 3-6 parts of bunge cherry seed.
In order to achieve the purpose, the invention also provides a preparation method of the traditional Chinese medicine preparation with the weight-losing function, which specifically comprises the following steps.
Step 1, pretreatment: the materials are received according to the production instruction, the code, name, specification, number, weight and the like of the materials are checked, and coat removal and disinfection are carried out.
Step 2, granulating: taking the following components in proportion: pseudo-ginseng, burdock, cassia seed, astragalus, bighead atractylodes rhizome, poria cocos, lotus leaf, selfheal, fructus cannabis and bunge cherry seed; extracting with ethanol, recovering ethanol, concentrating to 50% of the weight of the original ethanol extract, standing at 20-30 deg.C room for 3 hr to precipitate completely, filtering, concentrating the filtrate at 40-45 deg.C to obtain soft extract with specific gravity of 1.30, adding cyclodextrin, mixing with sugar powder, adding 50% ethanol 5-20% of the weight of the soft extract, adjusting humidity and viscosity to obtain soft material, adding into hopper of swing granulator, rotating repeatedly with a hexagonal prismatic rotating shaft, and making into wet granule with a screen (10-14 mesh); the wet granule standard is that the wet granule is placed in the palm to shake, heavy feeling should be generated, the fine powder is less, and the wet granule is regular in size and has no long strip; the weight ratio of the sugar powder, the dextrin and the thick extract (the specific gravity is 1.35-1.40, and the temperature is 50-60 ℃) is generally 3: 1: 1, the water content of the dry particles is controlled to be less than or equal to 6.0 percent and can be properly adjusted according to the specific gravity, the property and the purpose of medication of the thick extract.
And step 3, drying: and (3) after granulation, drying at 40-45 ℃ for 6-8 hours.
Step 4, straightening granules: after the particles are dried, part of the particles are agglomerated and adhered; cooling the dried material in a granulator, sieving again, removing coarse particles with 14 mesh sieve, and removing fine powder with 60 mesh sieve to obtain uniform granules (the fine powder can be re-granulated).
Step 5, mixing and filling: adding the material after the whole grains are finished in the step 4 into the compressible starch (the weight ratio of the whole grains to the starch is 4: 1), uniformly mixing in a mixer, and then packaging on an automatic packaging machine.
Step 6, thermal shrinkage: and (4) beating the prepared small packaged product for a corresponding production date, and sleeving a heat shrinkage film for heat shrinkage.
Step 7, metal detection: and (4) placing the product subjected to heat shrinkage on a food metal detector for detection, and then packaging and packaging to obtain a finished product.
And step 8, warehousing: and placing the finished product into a product qualified area of a storehouse.
The Chinese medicinal preparation can be prepared into granules, pills, powder, tea drinks and the like.
The traditional Chinese medicine preparation has the unique health-care effects of strengthening the spleen and stomach, increasing appetite, promoting digestion, preventing constipation, decomposing blood cholesterol and the like.
And analyzing the components of the raw materials.
Notoginseng radix can both dissipate blood stasis and stop bleeding, and tonify qi and blood. The ' Bencao gang mu Shi Yi ' cloud ' has slightly sweet and bitter taste, rather similar ginseng, ginseng tonifies qi firstly, notoginseng replenishes blood firstly, has the same taste and the same work and the like, and people with the same name as ginseng and notoginseng are the most precious of medicines, cooked notoginseng is often stewed with hen for postpartum blood deficiency, and the notoginseng has ginseng-like qi tonifying and strengthening effects, but has no ginseng-like absentmindedness phenomenon, and is known as ' king of ginseng '. Pseudo-ginseng is also used for treating diseases related to qi deficiency clinically, qi tonifying and yang rising are basic principles of treatment, and pseudo-ginseng has a good curative effect on the diseases and has the effect of tonifying qi.
Semen cassiae has the effects of relaxing bowel, reducing blood fat and improving eyesight, and is mainly used for treating constipation, hyperlipidemia and hypertension clinically; clearing liver-fire, improving vision, inducing diuresis, relaxing bowels and relieving diarrhea.
Radix astragali has effects of invigorating qi, consolidating superficial resistance, inducing diuresis, and relieving swelling, and is suitable for treating internal injury, fatigue, spleen deficiency, diarrhea, qi deficiency, blood deficiency, and qi deficiency; radix astragali has effects of reducing blood viscosity, reducing thrombosis, lowering blood pressure, protecting heart, regulating blood sugar, resisting free radical injury, resisting aging, resisting anoxia, resisting tumor, and enhancing immunity, and can be used for treating heart disease, hypertension, diabetes, etc.
The bighead atractylodes rhizome has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, is used for treating spleen and stomach qi deficiency, spleen deficiency diarrhea, dyspepsia and gastrointestinal diseases, is used for regulating the middle warmer and tonifying the spleen, and is used for removing dampness and tonifying qi and matched with a tonifying prescription to tonify qi and blood; it can also dry dampness and induce diuresis, so it is a good herb for treating phlegm-fluid retention edema and is indicated for various kinds of edema.
Poria cocos, Poria cocos wolf, radix astragali and Atractylodes macrocephala are often used in combination, because Poria cocos, has the effects of both strengthening the spleen and eliminating dampness, and treating diarrhea and leukorrhagia caused by dysfunction of transportation and transformation due to spleen deficiency, has the effect of addressing both the symptoms and root causes. Can be used as an adjuvant drug for tonifying lung and spleen and treating qi deficiency; tuckahoe, Poria induces diuresis and removes dampness, but has mild drug properties, induces diuresis without damaging healthy qi, and is the essential herb for inducing diuresis and removing dampness; it is indicated for difficult urination and retention of water-dampness, either due to cold-dampness or damp-heat or spleen deficiency with dampness accumulation.
The lotus leaf is bitter and astringent, slightly salty, pungent and cool in nature, and has the effects of clearing summer heat, promoting diuresis, invigorating yang, dispersing, removing blood stasis and stopping bleeding. The infusion and decoction of lotus leaf can expand blood vessel, clear away summer heat, lower blood pressure and reduce weight. The lotus leaf tea can also obviously reduce the content of triglyceride and cholesterol in serum and has the health-care function of regulating blood fat. The lotus leaf is often used as a health-care tea in folks, is not as instant as a medicine, but has no side effect, and is the most ideal choice for people with three highs, namely hypertension, hyperlipidemia and hypercholesterolemia, middle-aged and old people and women who want to keep slim.
Spica Prunellae, clears heat and purges fire, dissipates stasis and subsides swelling, and is good at purging liver fire for improving eyesight; it is indicated for up-flaming of liver fire, red eyes with swelling and pain, clearing liver heat and improving vision, and is indicated for liver yin deficiency, eye bead pain, especially at night.
Great burdock achene is cold in nature and pungent and bitter in taste; cold can clear heat, bitter can purge, pungent can disperse, and is suitable for various constipation due to heat-toxin and body fluid consumption; the great burdock achene enters lung meridian and can descend lung qi, the lung and large intestine are exterior and interior, and the descending of the large intestine depends on the dispersion and purification of lung qi; the burdock enters the stomach channel to reduce stomach qi, food residues descend to the large intestine when the stomach qi descends, and then are turned into excrement to be discharged out of the body, and the burdock has the function of promoting the stomach power.
Huo Ma ren has the actions of moistening dryness, relaxing bowels and tonifying consumptive disease, is suitable for old people with constipation due to asthenia, and can also be used for patients with excess heat in intestines, and has the action of tonifying consumptive disease, and is suitable for patients with intestinal dryness due to yin deficiency, and is often used together with qi-tonifying and body fluid-generating medicines to nourish yin, tonify deficiency and moisten dryness.
Semen Pruni has effects of moistening dryness, smoothing intestine, descending qi, and promoting diuresis; treating large intestine stagnation of qi, dryness, difficulty in micturition, abdominal edema, edema of limbs, and tinea pedis; the bunge cherry seed can promote qi generation of pylorus, moisten dryness of large intestine to promote qi circulation, moisten dryness and dredge intestine, has the functions of inducing diuresis and relieving swelling, and belongs to the purgative medicament.
The invention has remarkable effect.
The prescription takes four medicines of fructus cannabis, bunge cherry seed, great burdock achene and cassia seed as the monarch medicines; the ministerial drugs comprise pseudo-ginseng, astragalus root, largehead atractylodes rhizome and tuckahoe; folium Nelumbinis and Prunellae Spica can be added. Semen Pruni has effects of moistening and descending, activating qi-flowing, relaxing bowels, and promoting purgation, and can be used for treating constipation due to qi stagnation and dryness in large intestine; fructus cannabis, which is good at lubricating the dryness and intestine, relaxing the bowels and purgation, is used for constipation due to dry body and blood; the two components are mutually reinforced to play the efficacy of tonifying deficiency, moistening intestines and relaxing bowels, the burdock has the effects of relaxing bowels, removing food retention and eliminating phlegm, namely relaxing bowels and stopping diarrhea, the cassia seed has the effects of relaxing bowels, reducing fat and improving eyesight, the bunge cherry seed, the fructus cannabis, the burdock and the cassia seed can be used for relaxing bowels, the effects of relaxing bowels are different, the qi-moving and relaxing bowels are used, the dryness-moistening and relaxing bowels are used, the food retention and relaxing bowels are used, the fat-reducing and relaxing bowels are used, all the plant seeds are used for tonifying, and the tonifying effect is realized, so that the effects of purging and stopping diarrhea are realized. The radix notoginseng, the radix astragali, the rhizoma atractylodis macrocephalae and the poria cocos are used together as ministerial medicines, the rhizoma atractylodis macrocephalae has the effects of tonifying spleen and replenishing qi, drying dampness and regulating the middle warmer, and has the strong effects of tonifying spleen and drying dampness, the poria cocos has the effects of promoting diuresis and excreting dampness, strengthening spleen and regulating the middle warmer and is good for excreting dampness, the effects of tonifying spleen and drying dampness are more remarkable, namely the spleen can be strengthened and dried dampness, the monarch medicines are used for reducing blood fat, and the spleen and the stomach are prevented from being injured by excessive purgation of the monarch medicines; qi deficiency of spleen and spleen of a person is nourished to generate phlegm, phlegm dampness stagnates for a long time to remove blood stasis, pseudo-ginseng has the functions of regulating blood and activating blood, astragalus has the effect of tonifying qi, qi circulation is blood circulation, and qi stagnation is blood stasis, so that the effects of promoting qi and activating blood are excellent when the pseudo-ginseng and the astragalus are used together. The lotus leaves and the selfheal are adjuvant drugs, and the lotus leaves have the effects of clearing summer heat, removing dampness and removing stasis, facilitating urination and relaxing bowels, and tonifying spleen and invigorating yang. The selfheal can clear liver fire and dissipate stagnation, is frequently drunk as tea in folk, is used for dispelling damp heat and preventing heatstroke and cooling, has the functions of clearing heat, clearing phlegm heat, resolving dampness and dispelling stagnant heat, and is used as an adjuvant drug together.
The medicines of the invention are combined and supplement each other, so that the invention has definite weight-losing and health-care effects. The formula is based on the theory of traditional Chinese medicine, mainly eliminates dampness and promotes diuresis, strengthens spleen, promotes blood circulation and blood enriching, promotes qi circulation and invigorates qi, effectively helps to condition viscera and endocrine, enables qi and blood of a body to better run, can remove redundant water in the body and metabolic wastes and toxins accumulated in the body, and accelerates metabolism.
According to the theory of traditional Chinese medicine, obesity is related to qi deficiency, phlegm, dampness and blood stasis. The traditional Chinese medicine considers that the spleen and the stomach are damaged, the spleen does not disperse essence, or the spleen and the kidney are insufficient, the water channel is unfavorable, the ointment is changed into grease, phlegm and dampness, and the internal organs are accumulated to form obesity, so that the visceral dysfunction is the pathological basis of the obesity, namely the endocrine dyscrasia in western medicine, namely the imbalance between hunger sensation nerve and satiety nerve is regulated, and the imbalance of nutrition absorption is caused. Compared with other weight-reducing products, the formula breaks through the traditional understanding according to the modern Chinese medicine theory and achieves the purpose of reducing weight by regulating internal secretion. By adjusting the nerve and endocrine functions of the obese patient, on one hand, the weight loss health care food can suppress the hyperactive appetite of the obese patient, reduce the food intake, simultaneously suppress the hyperactive gastrointestinal digestion and absorption function of the patient, reduce the absorption of the body to energy, thereby reducing the intake of energy, on the other hand, the weight loss health care food can promote energy metabolism, increase energy consumption, promote the mobilization and lipolysis of body fat, and finally realize the weight loss effect. The formula applies the traditional Chinese medicine, has small side effect of weight reduction, can safely reduce the weight of patients without side effect, has no adverse reaction such as dizziness, diarrhea, vomit and the like caused by non-destructive weight reduction, and has no toxic substance residue in vivo. After a period of administration, the body metabolism reaches a new "regulation point" and the body weight stabilizes at a new level. The formula selects the Chinese medicinal materials which can tonify qi and invigorate spleen, are safe and have no toxic or side effect to form a compound, has remarkable effects of losing weight, invigorating spleen and combining stomach, and has consolidated and lasting treatment effect and difficult relapse.
Detailed Description
The present invention will be further described with reference to the following specific examples.
Example 1.
The traditional Chinese medicine weight-losing formula comprises the following raw materials in parts by weight: 30 parts of pseudo-ginseng, 20 parts of burdock, 20 parts of cassia seed, 15 parts of astragalus, 15 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 10 parts of lotus leaf, 10 parts of selfheal, 6 parts of fructus cannabis and 6 parts of bunge cherry seed.
The preparation method of the traditional Chinese medicine formula for losing weight comprises the following steps.
Step 1, pretreatment: the materials are received according to the production instruction, the code, name, specification, number, weight and the like of the materials are checked, and coat removal and disinfection are carried out.
Step 2, granulating: taking the following components in proportion: pseudo-ginseng, burdock, cassia seed, astragalus, bighead atractylodes rhizome, poria cocos, lotus leaf, selfheal, fructus cannabis and bunge cherry seed; extracting with ethanol, recovering ethanol, concentrating to 50% of original weight, standing at 30 deg.C room for 3 hr to precipitate completely, filtering, concentrating the filtrate at 40-45 deg.C to obtain soft extract with specific gravity of 1.30, placing in dry container, adding cyclodextrin, mixing with sugar powder, adding 50% ethanol 20% of the weight of the soft extract, adjusting humidity and viscosity to obtain soft material "kneading into lumps under hand and dispersing under light pressure", adding into hopper of swing granulator, rotating with blunt hexagonal prismatic rotating shaft to make reciprocating rotation, and extruding with screen (10-14 mesh) to obtain wet granules; the wet granule standard is that the wet granule is placed in the palm to shake, heavy feeling should be generated, the fine powder is less, and the wet granule is regular in size and has no long strip; the weight ratio of the sugar powder, the dextrin and the thick extract (the specific gravity is 1.35, 60 ℃) is 3: 1: 1, the water content of the dry particles is controlled to be less than or equal to 6.0 percent and can be properly adjusted according to the specific gravity, the property and the purpose of medication of the thick extract.
And step 3, drying: after granulation, drying treatment is carried out, the drying temperature is controlled at 40 ℃, and the drying time is 8 hours.
Step 4, straightening granules: after the particles are dried, part of the particles are agglomerated and adhered; cooling the dried material in a granulator, sieving again, removing coarse particles with 14 mesh sieve, and removing fine powder with 60 mesh sieve to obtain uniform granules (the fine powder can be re-granulated).
Step 5, mixing and filling: and (4) adding the compressible starch into the whole grain material obtained in the step (4), uniformly mixing in a mixer, and then packaging on an automatic packaging machine.
Step 6, thermal shrinkage: and (4) beating the prepared small packaged product for a corresponding production date, and sleeving a heat shrinkage film for heat shrinkage.
Step 7, metal detection: and (4) placing the product subjected to heat shrinkage on a food metal detector for detection, and then packaging and packaging to obtain a finished product.
And step 8, warehousing: and placing the finished product into a product qualified area of a storehouse.
First, the traditional Chinese medicine weight-losing formula of embodiment 1 of the invention has an influence experiment on mouse weight and serum biochemical indexes.
1. Experimental materials: 60 SD mice, male random, weight 16-20g (provided by Liaoning university of traditional Chinese medicine laboratory animal center), enzyme method serum determination kit (Shanghai Fusheng industry Co., Ltd.).
2. Experimental drugs: the weight-reducing traditional Chinese medicine formula alcohol extract (density is 1.3) is prepared by self, and the high-nutrition feed (10 g of milk powder, 10 g of lard oil, 1 egg and 10 drops of cod liver oil) is prepared by self.
3. And (4) experimental animals.
3.1 grouping of experimental animals.
The weight-losing and lipid-lowering experiment: taking 30 mice, randomly dividing into 3 groups, wherein each group comprises 10 mice, namely a normal lipid-lowering group, a control lipid-lowering group and a traditional Chinese medicine lipid-lowering group; control group experiment: 30 mice are taken and randomly divided into 3 groups, each group comprises 10 mice, and the groups respectively comprise a normal weight-reducing fat group formula group (the normal group formula group in the example 1), a monarch group (pseudo-ginseng, astragalus, bighead atractylodes rhizome, poria cocos, lotus leaves and selfheal), and a ministerial drug group (fructus cannabis, bunge cherry seed, burdock, cassia seed, lotus leaves and selfheal).
3.2 experimental animal feeding: feeding normal mice with the lipid-lowering group with common mouse food, feeding the control group with the lipid-lowering traditional Chinese medicine with self-made high-nutrition feed, continuously feeding the mice for 30 days, feeding 3 groups of mice with free diet, wherein the feeding environment temperature is 20-28 ℃, and the humidity is 60-70%. The mice for the fatigue resistance experiment are all supplied with common mouse food and are continuously fed for 30 days.
3.3 administration to laboratory animals.
The mice in the lipid-lowering traditional Chinese medicine group are fed with the traditional Chinese medicine weight-losing formula for 0.2 mL/mouse and 1 time/d, and the mice in the lipid-lowering normal group and the lipid-lowering control group are fed with the same amount of distilled water continuously for 30 d. The anti-fatigue traditional Chinese medicine group mice are fed with the traditional Chinese medicine weight-reducing formula for 0.2 mL/mouse and 1 time/day, and the anti-fatigue control group is fed with the same amount of distilled water for 30 days continuously.
4. Observation indexes and statistical methods.
The influence of the traditional Chinese medicine weight-reducing formula on the weight and fat coefficient of the mouse, the influence of the content of total cholesterol and triglyceride in serum of the mouse and the influence of the fatigue resistance of the mouse are observed. Statistical analysis of the data was performed using Excel2003 software, and the metrology data are expressed as standard deviation (x ± s).
5 animal experiment results.
5.1 influence of the traditional Chinese medicine weight-reducing formula on the body mass of mice.
In the process of lipid-lowering experiment, 3 groups of mice were respectively weighed at 6 days, 12 days, 18 days, 24 days and 30 days of feeding, sacrificed after 30 days, and the fat weight around the genitals was taken to calculate the fat coefficient, i.e.,% fat coefficient (= (fat weight/mouse weight) × 100%). The body weight changes of the mice before and after the experiment are shown in table 1.
As can be seen from Table 1, the weight of the mice in the lipid-lowering control group increased at a lower rate in the early stage than that in the normal group, but at the later stage, the weight of the mice in the normal group was higher than that in the later stage of the test, indicating that the nutritional feed has the effect of increasing the weight. The weight growth speed of the mice with the traditional Chinese medicine for reducing the fat is obviously less than that of a normal group and a control group for reducing the fat, and the weight-reducing formula with the traditional Chinese medicine has the function of reducing the weight. The statistical analysis result shows that the body weight change difference of the control group mouse and the normal group mouse reaches a significant level (P <0.05), and the body weight growth change of the traditional Chinese medicine group mouse and the control group mouse have a very significant difference (P < 0.01).
5.2 the effect of the weight-reducing formula on the quality and fat coefficient of mouse genital fat is shown in Table 2.
As can be seen from Table 2, the fat mass and fat coefficient around the genitals of the mice in the fat-reducing control group are both obviously (P <0.05) higher than those of the mice in the normal control group, and the fat mass and fat coefficient around the genitals of the mice in the control group are obviously reduced compared with those in the control group, which shows that the weight-reducing effect of the traditional Chinese medicine weight-reducing prescription is obvious.
5.3 the effect of the traditional Chinese medicine weight-reducing formula on the total cholesterol and triglyceride of the serum of the mouse.
After feeding the mice 30 times, the mice are sacrificed, blood is collected from the heart, serum is separated (the blood is kept still for 30min, centrifuged at 3000 r/min for 15min, and supernatant is taken), and fasting is carried out for 16h before blood collection. The total cholesterol and triglyceride content in serum was determined by enzymatic assay kit, see table 3.
As can be seen from Table 3, the serum total cholesterol and triglyceride concentrations of the control group mice were significantly higher (P <005) than those of the normal group, demonstrating that the nutritional feed can cause significant increases in the serum total cholesterol and triglyceride concentrations of the mice. The concentration of total cholesterol and triglyceride in the serum of the traditional Chinese medicine mouse is very obvious (P is less than 0.01) and is lower than that of a control group, which shows that the weight-reducing formula of the traditional Chinese medicine has obvious effect of reducing blood fat.
5.4 the normal traditional Chinese medicine weight-reducing formula is compared with a traditional Chinese medicine formula which does not contain monarch drugs and ministerial drugs.
5.4.1 Effect of Normal Chinese medicinal lipid-lowering formula on mouse body weight.
The mice of 3 groups are respectively weighed on the 6 th day, 12 th day, 18 th day, 24 th day and 30 th day by using a normal formula group and no monarch drug-free group and no minister drug-free group, and are sacrificed after 30 days, the fat weight around the genitals is taken, and the fat coefficient is calculated as the fat coefficient% = (fat weight/mouse weight). times.100%. The body weight changes of the mice before and after the experiment are shown in table 1.
As can be seen from table 4, after the experiment, the weight growth rate of the mice in the normal group of the weight-reducing and lipid-lowering traditional Chinese medicine formula is obviously lower than that of the mice without monarch medicine and ministerial medicine, which indicates that the weight-reducing traditional Chinese medicine formula in the normal formula has the function of obviously reducing the weight. Compared with the mouse without monarch drug, the weight growth speed of the mouse without the monarch drug is obviously lower than that of the mouse without the monarch drug, which shows that the monarch drug plays a main role in reducing fat in the whole weight and fat formula. The statistical analysis result shows that the body weight change difference of the control group mouse and the normal group mouse reaches a significant level (P <0.05), and the body weight growth change of the traditional Chinese medicine group mouse and the control group mouse have a very significant difference (P < 0.01).
5.4.2 the influence of the normal formula traditional Chinese medicine weight-losing and lipid-lowering formula on the quality and fat coefficient of the peripheral fat of mouse genitals and the influence of the traditional Chinese medicine weight-losing and lipid-lowering formula without monarch drug group and ministerial drug group are shown in a table 5.
As can be seen from the table 5, the fat mass and fat coefficient around the mouse genitals in the normal formula traditional Chinese medicine weight-reducing formula are both remarkably lower (P is less than 0.05) than those without monarch drug and ministerial drug, and the fat mass and fat coefficient around the mouse genitals in the ministerial drug-free group are remarkably reduced compared with those without monarch drug, which shows that the weight-reducing effect of the normal formula traditional Chinese medicine weight-reducing formula is most remarkable, and the monarch drug plays a main role in reducing weight and fat.
Example 2.
The traditional Chinese medicine weight-losing formula comprises the following raw materials in parts by weight: 25 parts of pseudo-ginseng, 18 parts of burdock, 12 parts of scutellaria baicalensis, 6 parts of semen cassiae, 6 parts of bighead atractylodes rhizome, 6 parts of poria cocos, 6 parts of lotus leaves, 6 parts of bunge cherry seeds, 3 parts of selfheal and 3 parts of fructus cannabis.
Example 3.
The traditional Chinese medicine weight-losing formula comprises the following raw materials in parts by weight: 28 parts of pseudo-ginseng, 15 parts of burdock, 15 parts of cassia seed, 12 parts of bighead atractylodes rhizome, 12 parts of poria cocos, 12 parts of selfheal, 6 parts of lotus leaf, 6 parts of scutellaria baicalensis, 3 parts of bunge cherry seed and 6 parts of fructus cannabis.
Typical cases.
Case 1: wangzhi, male, 13 years old, student, height 152cm, weight 145 jin. Since the child is slightly fat from young than the same-age child, the weight of the queen-son is rapidly increased after the early school, and because the queen-son is subjected to the same-theory jeers, the parents pay attention to the achievement regression of the child in the recent period and silence the whisper, and the child comes from the hospital to see a doctor. The current symptoms are as follows: the body fat is accumulated in the abdomen and the buttocks, the lower limbs are fat, the qi is short during the activity, the fatigue is often felt, the appetite is vigorous, and the appetite is fat and sweet. Treatment: weight reducing prescription, meridian-following massage therapy and ear acupuncture therapy. The prescription is as follows: example 1, oral administration, twice daily. After three months, the weight is reduced by 43 jin, and other symptoms disappear.
Case 2: li in certain, male, 44 years old, private enterprises and old men, height 175cm, 262 jin. The diet has high heat when being taken out of the night frequently, and is inconvenient to move gradually and causes a plurality of problems on the health because the work needs to drink the wine frequently and is not easy to exercise, and the weight is increased from 120 jin to 262 jin in a few years. The patient is admitted to the hospital for treatment 5-6 months in 2013. The current symptoms are as follows: palpitation, dizziness, fever, hyperhidrosis, increased appetite, sudden weight gain, knee pain, dark urine. Treatment: the Chinese medicinal weight reducing decoction, acupoint selection massage therapy along channels, and Chinese medicinal soaking. During hospitalization, the weight-reducing traditional Chinese medicine decoction is taken twice a day, and in example 1, the decoction is taken orally twice a day. The massage treatment is carried out once a day along the channels. When palpitation is obvious, a certain amount of tribromo mixture is temporarily given once, and the pain-relieving and stasis-removing decoction and the traditional Chinese medicine of the Ermiao decoction are used for soaking the lower limbs once a day for 30 minutes each time, so that the knee pain is treated. Discharge from the hospital in 2013, 7 and 11 months, and relieve discharge symptoms, reduce sweating, knee pain, palpitation and improvement, and lose weight for 22 jin. Patients still take the medicine in front twice a day after discharge, and are subjected to repeated diagnosis in 10 months, all symptoms are obviously reduced, and the weight is reduced by 59 jin.
Case 3: female, 35 years old, teacher, height 162cm, weight 145 jin. After delivery, fat is accumulated continuously, and the body shape is deformed. Many weight loss methods have been tried and have failed. The current symptoms are as follows: the abdominal muscles are relaxed, fat is deposited on the abdomen, and the body is tired. Treatment: the traditional Chinese medicine weight-reducing prescription decoction and acupuncture treatment. The prescription is as follows: example 2, oral administration, twice daily. Acupuncture treatment is performed once a day. Aiming at the root cause of postpartum obesity of women, starting from the regulation of an endocrine system, decoction acupuncture therapy is adopted to be matched to dredge the circulation of channels and collaterals, regulate the functions of viscera, effectively improve the dehumidification function of spleen and accelerate the dehumidification at the same time. The formula is modified according to symptoms, and the weight is reduced by 21 jin after three months, and the symptoms are reduced by diet.
Claims (2)
1. A traditional Chinese medicine prescription with a weight-losing function is characterized by comprising the following raw materials in parts by weight: 25-30 parts of pseudo-ginseng, 15-20 parts of burdock, 15-20 parts of cassia seed, 10-15 parts of astragalus membranaceus, 10-15 parts of bighead atractylodes rhizome, 10-15 parts of poria cocos, 5-10 parts of lotus leaf, 5-10 parts of selfheal, 3-6 parts of fructus cannabis and 3-6 parts of bunge cherry seed;
the preparation method of the traditional Chinese medicine prescription with the weight-losing function is characterized by comprising the following steps:
step 1, pretreatment: getting the material according to the production instruction, checking the code, name, specification, number and weight of the material, and removing coat and sterilizing;
step 2, granulating: taking the following components in proportion: pseudo-ginseng, burdock, cassia seed, astragalus, bighead atractylodes rhizome, poria cocos, lotus leaf, selfheal, fructus cannabis and bunge cherry seed; extracting with ethanol, recovering ethanol, concentrating to 50% of original weight, standing at 20-30 deg.C for 3 hr to precipitate completely, filtering, concentrating the filtrate at 40-45 deg.C to obtain soft extract with specific gravity of 1.30 g/ml, adding into dry container, adding soft extract, stirring, adding 10-20% 50% ethanol, adjusting humidity and viscosity to obtain soft material, adding into hopper of swing granulator, rotating with hexagonal rotating shaft to make wet granules by 10-14 mesh; the wet granule standard is that the wet granule is placed in the palm to shake, heavy feeling should be generated, the fine powder is less, and the wet granule is regular in size and has no long strip; the weight ratio of the sugar powder, the dextrin and the thick extract is 3: 1: 1, properly adjusting according to the specific gravity and the property of the thick extract and the purpose of medication, and controlling the water content of dry particles to be less than or equal to 6.0 percent; the specific gravity of the thick extract is 1.35-1.40g/ml at 50-60 ℃;
and step 3, drying: after granulation, drying treatment is carried out, the drying temperature is controlled to be 40-45 ℃, and the drying time is 6-8 hours;
step 4, straightening granules: after the particles are dried, part of the particles are agglomerated and adhered; cooling the dried material in a granulator, sieving again, removing coarse particles by using a 14-mesh sieve, and removing fine powder by using a 60-mesh sieve to ensure that the particles are uniform;
step 5, mixing and filling: adding compressible starch into the material after the whole grains are finished in the step 4, wherein the weight ratio of the whole grains to the starch is 4: 1, uniformly mixing in a mixer, and then packaging on an automatic packaging machine;
step 6, thermal shrinkage: the prepared small packaged product is printed with corresponding production date, and a thermal shrinkage film is sleeved for thermal shrinkage;
step 7, metal detection: placing the product subjected to heat shrinkage on a food metal detector for detection, and then packaging and packaging to obtain a finished product;
and step 8, warehousing: and placing the finished product into a product qualified area of a storehouse.
2. The traditional Chinese medicine prescription with the function of losing weight as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 30 parts of pseudo-ginseng, 20 parts of burdock, 20 parts of cassia seed, 15 parts of astragalus, 15 parts of bighead atractylodes rhizome, 15 parts of poria cocos, 10 parts of lotus leaf, 10 parts of selfheal, 6 parts of fructus cannabis and 6 parts of bunge cherry seed.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1568797A (en) * | 2004-04-28 | 2005-01-26 | 尹运贵 | Nutritious preparation and its making method |
| JP2015140333A (en) * | 2014-01-30 | 2015-08-03 | 松浦薬業株式会社 | Fat combustion accelerator composition |
| CN108014226A (en) * | 2017-12-18 | 2018-05-11 | 王富春 | A kind of Chinese medicine for being used to lose weight |
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