CN113827541B - Essence emulsion composition with black eye removing and pouch removing effects and preparation method thereof - Google Patents
Essence emulsion composition with black eye removing and pouch removing effects and preparation method thereof Download PDFInfo
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- CN113827541B CN113827541B CN202111139412.XA CN202111139412A CN113827541B CN 113827541 B CN113827541 B CN 113827541B CN 202111139412 A CN202111139412 A CN 202111139412A CN 113827541 B CN113827541 B CN 113827541B
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- eye
- dark circles
- emulsion composition
- essence
- removing dark
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- 238000012546 transfer Methods 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 230000008320 venous blood flow Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses an essence emulsion composition with the effects of removing dark circles and bags, and a preparation method and application thereof. The essence emulsion composition comprises the following raw material components: 0.5-35% of functional components for removing black eyes and bags, 0.5-40% of emollient, 1-20% of emulsifier, 0.5-25% of filler, 0.5-20% of thickener, 0.1-10% of preservative, 0.01-5% of pH regulator, 0.001-4% of daily essence and the balance of deionized water. The components with the efficacy of removing dark circles and bags comprise: acetyl tetrapeptide-5, lactobacillus fermentation lysate, nicotinamide, fucus serrulata extract. The essence emulsion composition with the effects of removing dark circles and the eye bags can reduce pigment accumulation of eye skin, improve permeability of blood vessels around eyes, reduce edema of eyes and resist eye bags through the compound use of the components, so that the essence emulsion composition has the effects of effectively removing dark circles of eyes and improving the problems of the skin around eyes such as the eye bags.
Description
Technical Field
The invention relates to a skin care product and a preparation method and application thereof, belongs to the technical field of daily chemicals, and in particular relates to an essence emulsion composition with the effects of removing dark circles and eye bags and a preparation method thereof.
Background
The eyes are the focus of attention of a person, and are of great importance for beautiful presentation, and proper care of the periocular region helps to improve the aesthetic feeling of a person. The most plagued problems in the periocular region are dark circles and bags, and the current fast-paced, high-pressure life further causes periocular skin crisis, so eye care is becoming more and more important.
Nowadays, people often have problems of insufficient sleep, eye fatigue and the like in a fast-paced life and a high-pressure working environment, and the problems can slowly cause blood stasis and edema of skin around eyes, and the thin barrier function of keratinocyte layers at the skin of the eyes is weak. Over time, the effect of the eye drops is that dark circles, edema, eye bags, loose eye skin and the like appear around the eyes.
The occurrence of black eye is caused by various factors, the most common black eye is that the blood flow velocity of blood vessels of skin around eyes is low due to night, venous blood flow is caused, and partial supply around eyes is insufficient, so that the accumulation of eye pigment is caused, the metabolism is slow, and the black eye is formed slowly.
In addition, there are dark circles caused by pigmentation around the eyes due to long-term sun exposure, dark circles caused by deep skin tone due to aging of the eyelid and loose skin wrinkling, or shadows due to the appearance of the pouch. The factors causing the black eye are various, people with the factors possibly happen at the same time, people can accept and effectively relieve the black eye, and the eye bag measures are solved through skin care products.
Therefore, how to prepare a skin care product which can effectively prevent and reduce the occurrence of dark circles caused by multiple factors and has safe and effective components is a technical problem which is urgently needed to be solved by the technicians in the field.
Disclosure of Invention
The invention aims to provide an essence emulsion composition with the functions of removing dark circles and eye bags, which can reduce pigment accumulation of eye skin, improve permeability of blood vessels around eyes, reduce edema of eyes and resist eye bags when applied to the essence emulsion, thereby having the functions of effectively removing dark circles of eyes and improving problems of skin around eyes such as eye bags. It will be appreciated by those who have been plagued with dark circles.
The invention also aims to provide a preparation method and application of the essence emulsion composition with the efficacy of removing dark circles and under-eye puffiness.
An essence emulsion composition with effects of removing black eye and pouch comprises 0.5-35% of effective components for removing black eye and pouch, and 65-99.5% of cosmetic adjuvant matrix; the functional components for removing dark circles and the pouch comprise: acetyl tetrapeptide-5, lactobacillus fermentation lysate, nicotinamide, fucus serrulata extract.
Preferably, the cosmetic auxiliary material matrix is composed of an emollient, an emulsifier, a filler, a thickener, a preservative, a pH regulator, a daily essence and deionized water.
An essence emulsion composition with the efficacy of removing dark circles and eye bags comprises the following components in percentage by weight:
0.5-35% of an effective component for removing dark circles and under-eye puffiness, comprising: 0.1-10% of acetyl tetrapeptide-5, 0.1-8% of lactobacillus fermentation lysate, 0.1-10% of nicotinamide, 0.1-12% of Fucus vesiculosus extract;
65-99.5% of a cosmetic adjuvant matrix comprising: 0.5-40% emollient; 1-20% of an emulsifier; 0.5-25% filler; 0.5-20% of a thickener; 0.1-10% preservative; 0.01-5% of a pH regulator; 0.001-4% of daily essence; the balance of deionized water.
Preferably, the composition is composed of the following components, based on the total weight of the composition:
1-15% of an effective component for removing dark circles and under-eye puffiness, which comprises: 0.2-4% of acetyl tetrapeptide-5, 0.1-5% of lactobacillus fermentation lysate, 0.5-5% of nicotinamide, 0.1-4% of Fucus vesiculosus extract;
85-99% of a cosmetic adjuvant matrix comprising: 5-35% of an emollient; 1-15% of an emulsifier; 1-20% of a filler; 1-15% of a thickener; 0.1-5% preservative; 0.01-4% of a pH regulator; 0.001-2% of daily essence; the balance of deionized water.
Preferably, the composition is composed of the following components, based on the total weight of the composition:
an active ingredient for removing dark circles and under-eye puffiness comprising: 0.2-1% of acetyl tetrapeptide-5, 1-2% of lactobacillus fermentation lysate, 0.5-2% of nicotinamide, 0.5-1.5% of Fucus vesiculosus extract;
a cosmetic adjuvant matrix comprising: 18-28% of an emollient; 2-4% of an emulsifier; 2-5% of filler; 10-15% of a thickener; 0.5-2% preservative; 0.03-1% of a pH regulator; 0.02-0.1% of daily essence; the balance of deionized water.
Preferably, the preparation method of the lactobacillus fermentation lysate comprises the following steps:
1) Lactobacillus species were used at 1: performing expansion culture in a seed culture medium according to the volume ratio of (5-10);
2) The lactic acid bacteria amplified in step 1) were treated with 1: inoculating the mixture to fermentation culture in a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotation speed of the shaking table is 50-200r/min, and the fermentation time is 5-12h;
3) Performing ultrasonic treatment on the fermentation broth obtained in the step 2) for 10-30min by using a cell ultrasonic pulverizer, centrifuging at a centrifugal speed of 10000r/min, taking supernatant and removing filter residues;
4) And 3) performing high-temperature sterilization on the supernatant obtained in the step 3), wherein the sterilization temperature is 95 ℃, and the sterilization time is 10-30min, so as to obtain the lactobacillus fermentation lysate.
More preferably, the lactobacillus species is selected from the group consisting of bifidobacteria, probiotics such as lactobacillus; the lactobacillus fermentation lysate is rich in active ingredients of lactobacillus cells such as peptidoglycan, extracellular polysaccharide, active peptide, amino acid and the like, and has the effects of resisting wrinkle, brightening skin, retaining water, reducing melanin deposition, improving skin flora balance and the like.
Preferably, the fucus tinctorius extract is obtained by supercritical carbon dioxide fluid extraction, and the preparation method comprises the following steps:
1) Cleaning raw materials, drying, pulverizing, and sieving to obtain raw material powder;
2) The method comprises the steps of (1) loading raw material powder into a supercritical extraction kettle, adjusting the pressure and the temperature of CO2, entering the supercritical extraction kettle from the bottom of the supercritical extraction kettle, adding a small amount of entrainer into the supercritical CO2 in a liquid form, fully contacting the supercritical CO2 with the raw material powder, and selectively dissolving out required chemical components;
3) The CO2 fluid containing the dissolved extract is depressurized by a pressure reducing valve and enters a separation kettle, the solubility of the solute is greatly reduced, so that the solute is separated out, and the extract can be obtained by concentrating the solute to dryness under reduced pressure.
More preferably, in the supercritical carbon dioxide fluid extraction preparation method, the extraction temperature is 35-60 ℃; the extraction pressure is 20-60Mpa; the extraction time is 1-4h; the entrainer is one or more of water, methanol, ethanol, acetone and propane.
Preferably, the emollient is selected from one or more of butylene glycol, hexylene glycol, stearyl alcohol, behenyl alcohol, caprylic glycol, caprylic capric triglyceride, squalane, avocado oil, soybean oil, shea butter, rapeseed oil, jojoba oil, hydrogenated polyisobutene, isododecane, phytosterols, polydecene, isononyl isononanoate;
preferably, the emulsifier is selected from one or more of polysorbate-20, sorbitan olive oleate, stearyl polyether-21, polysorbate-80, soybean lecithin PC60, glyceryl stearate, laureth-23, and poloxamer 407;
preferably, the filler is selected from one or more of boron nitride, volcanic ash, diatomite, mica, kaolin, talcum powder, starch octyl aluminum succinate and cellulose acetate;
preferably, the thickener is selected from one or more of glycerol, 1, 3-propanediol, carbomer, xanthan gum, acrylic acid (esters) type/C10-30 alkanol acrylate cross-linked polymer, gum arabic, hydroxyethyl cellulose, polymer EMT-10, sodium acrylate/sodium acryloyldimethyl taurate, acrylic acid (esters) type/C10-30 alkanol acrylate cross-linked polymer copolymer;
preferably, the pH modifying agent is one or more of lactic acid or arginine.
Specifically, the weight ratio of the acetyl tetrapeptide-5, the lactobacillus fermentation lysate, the nicotinamide and the fucus serrulata extract in the functional components for removing dark circles and the eye bags is 1: (2-5): (1-4): (1-2).
The preparation method of the essence emulsion composition with the efficacy of removing dark circles and eye bags comprises the following steps:
1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
2) Adding the functional components for removing dark circles and bags, the emollient, the filler, the preservative and the pH regulator into the mixed solution in the step 1), heating to 65 ℃, homogenizing for 3 minutes at 3000r/min to ensure that the functional components are completely dispersed;
3) Adding the emulsifying agent and the daily essence into the step 2), homogenizing for 3 minutes at 3000r/min to completely emulsify, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of removing dark circles and eye bags.
A cosmetic comprises the essence emulsion composition with the effects of removing dark under eye circles and bags prepared by the preparation method.
In particular, the essence emulsion composition with the efficacy of removing dark circles and bags of eyes is not limited to an essence emulsion formulation, and can be used in other cosmetic formulations.
In particular, the cosmetic is in the form of solvent dispersion or suspension, or in the form of emulsified particles, or in the form of polymer packages.
Specifically, the essence emulsion composition with moisturizing and soothing effects of the present invention has a pH in the range of 4 to 10, preferably a pH in the range of 5 to 8, and most preferably a pH in the range of 5 to 7.
By means of the technical scheme, the invention has the following beneficial technical effects:
1) The functional components of the black eye removing and pouch removing acetyl tetrapeptide-5, lactobacillus fermentation lysate and nicotinamide have the effects of reducing pigment accumulation of eye skin, improving the permeability of blood vessels around eyes, reducing edema of eyes and resisting pouch, and can effectively lighten the black eye of eyes and improve the problems of skin around eyes such as pouch and the like;
2) In addition, when the efficacy components for removing black eyes and the pouch are used in a compounding way, the problem of black eyes caused by multiple factors can be solved;
3) The innovative functional components for removing the black eye and the pouch are simultaneously applied to the essence emulsion, and can also play a role in cooperatively removing the black eye and the pouch.
Drawings
FIG. 1 is a graph showing the results of a black eye removal capability test of a black eye removal and pouch efficacy composition;
FIG. 2 is a graph showing the results of the pouch removal ability test of the pouch and dark circles removal efficacy composition;
FIG. 3 is a graph showing the rate of change of skin color L+ after use of the sample;
FIG. 4 is a graph showing the change rate of pouch volume after use of the sample;
FIG. 5 is the skin color ITA DEG change rate after use of the sample;
FIG. 6 is a graph showing skin melanin rate after use of the samples;
FIG. 7 is a graph showing skin stain change rate after use of the sample;
FIG. 8 is a comparison of the rate of change of skin color L using comparative examples 1-14 and example 1;
FIG. 9 is a comparison of the change rate of the pouch volume using comparative examples 1-14 and example 1;
fig. 10 is a comparison of the rates of change of skin color ita° using comparative examples 1-14 and example 1.
Detailed Description
The invention discloses an essence emulsion composition with the effects of removing dark circles and eye bags and a preparation method thereof. The essential emulsion composition mainly comprises the following functional components for removing dark circles and eye bags: acetyl tetrapeptide-5, lactobacillus fermentation lysate, nicotinamide, fucus serrulata extract.
The essence emulsion composition with the effects of removing dark circles and the eye bags can reduce pigment accumulation of eye skin, improve permeability of blood vessels around eyes, reduce edema of eyes and resist eye bags through the compound use of the components, so that the essence emulsion composition has the effects of effectively removing dark circles of eyes and improving the problems of the skin around eyes such as the eye bags.
Wherein acetyl tetrapeptide-5 can reduce vascular permeability, prevent liquid accumulation under the eyes, reduce bilirubin content, lighten dark circles, combat edema, and reduce fluid and fat type eye bags. In addition, the skin brightness under the eyes can be improved, and the effect of fading dark circles is further achieved.
The lactobacillus fermentation lysate is rich in active ingredients of lactobacillus cells such as peptidoglycan, exopolysaccharide, active peptide, amino acid and the like, and mainly plays a role in repairing and updating the skin barrier around eyes, and avoids deepening the appearance skin color caused by ageing and relaxing the skin wrinkling of the eyelid. In addition, the utility model can accelerate the epidermal regeneration and strengthen the thickness and barrier function of the horny layer, and can avoid the problems of periocular skin caused by thin periocular keratinocyte layer and weak barrier function.
Nicotinamide mainly plays a role in inhibiting pigment-type black eye caused by accumulation of melanin in epidermis. The nicotinamide can inhibit melanin transfer to epidermis, promote metabolism of epidermis melanin, and reduce pigmentation, thereby reducing dark circles.
The Fucus vesiculosus extract contains rich nutrients, can solve the problem of insufficient nutrient supply of the skin around eyes, can improve the respiration of mitochondria, can accelerate the metabolism of the skin, prevent the accumulation of local melanin around eyes, and can effectively wake up the vitality of the skin so as to restore the skin around eyes to be new and new.
The invention innovatively combines the four functional components for removing dark circles and the eye bags, can reduce pigment accumulation of eye skin, improve permeability of blood vessels around eyes, reduce edema of eyes and resist the effect of the eye bags, and can effectively lighten dark circles of eyes and improve the problems of the skin around eyes such as the eye bags.
The invention is illustrated by the following examples which are given for further illustration of the invention and are not intended to limit the scope of the invention. Some insubstantial modifications and adaptations of the invention by others are within the scope of the invention. The following percentages (%) are mass percentages unless otherwise indicated.
Examples 1 to 3
An essence emulsion composition with effects of removing black eye and pouch comprises the following raw materials in proportion as shown in table 1.
TABLE 1 raw material composition ratio (unit: mass%) of examples 1-3
The preparation process of the essence emulsion with the efficacy of removing dark circles and bags of eyes of the embodiment 1 comprises the following steps:
1) Preparation of lactic acid bacteria fermentation lysate:
bifidobacterium species were isolated at 1:5, performing expansion culture in a seed culture medium according to the volume ratio; spread bifidobacteria were grown at 1: inoculating the fermentation culture in a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotation speed of the shaking table is 100r/min, and the fermentation time is 12h; performing ultrasonic treatment on the fermentation broth by using a cell ultrasonic pulverizer for 30min, centrifuging at a centrifugal speed of 10000r/min, taking supernatant, and removing filter residues; and (3) performing high-temperature sterilization on the obtained supernatant, wherein the sterilization temperature is 95 ℃, and the sterilization time is 30min, so as to obtain the lactobacillus fermentation lysate.
Preparation of Fucus vesiculosus extract:
taking 20g of raw materials, cleaning, drying, crushing, and sieving with a 80-mesh sieve to obtain raw material powder for later use; the method comprises the steps of (1) loading raw material powder into a supercritical extraction kettle, allowing CO2 to enter from the bottom of the extraction kettle after pressure and temperature adjustment, adding a small amount of entrainer acetone into the supercritical CO2 in a liquid form, fully contacting the raw material powder, and selectively dissolving out required chemical components; the extraction temperature is 45 ℃; the extraction pressure is 40Mpa; the extraction time is 2 hours; the CO2 fluid containing the dissolved extract is depressurized by a pressure reducing valve and enters a separation kettle, the solubility of the solute is greatly reduced, so that the solute is separated out, and the extract can be obtained by concentrating the solute to dryness under reduced pressure.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) To the mixture in step 2) were added 0.4 parts of acetyl tetrapeptide-5, 1 part of lactic acid bacteria fermentation lysate, 0.8 parts of nicotinamide, 0.8 parts of Fucus vesiculosus extract.
4) Continuously adding an emollient, a filler, a preservative and a pH regulator into the mixed solution in the step 3), heating to 65 ℃, and homogenizing for 3 minutes at 3000r/min to enable the mixture to be completely dispersed;
5) Adding emulsifying agent and daily essence into the step 4), homogenizing for 3 min at 3000r/min to completely emulsify, and heating to 65deg.C to obtain essence emulsion composition with effects of removing black eye and eye pouch, wherein pH is 6.5-6.8.
The preparation process of the essence emulsion with the efficacy of removing dark circles and bags of eyes of the embodiment 2 comprises the following steps:
1) Preparation of lactic acid bacteria fermentation lysate:
lactobacillus species were used at 1:8, performing expansion culture in a seed culture medium according to the volume ratio; lactobacillus amplified at 1:8, inoculating the fermentation culture in a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotation speed of the shaking table is 120r/min, and the fermentation time is 10h; performing ultrasonic treatment on the fermentation broth by using a cell ultrasonic pulverizer for 30min, centrifuging at a centrifugal speed of 10000r/min, taking supernatant, and removing filter residues; and (3) performing high-temperature sterilization on the obtained supernatant, wherein the sterilization temperature is 95 ℃, and the sterilization time is 30min, so as to obtain the lactobacillus fermentation lysate.
Preparation of Fucus vesiculosus extract:
cleaning 50g of raw materials, drying, crushing, and sieving with a 80-mesh sieve to obtain raw material powder for later use; the method comprises the steps of (1) loading raw material powder into a supercritical extraction kettle, allowing CO2 to enter from the bottom of the extraction kettle after pressure and temperature adjustment, adding a small amount of entrainer acetone into the supercritical CO2 in a liquid form, fully contacting the raw material powder, and selectively dissolving out required chemical components; the extraction temperature is 45 ℃; the extraction pressure is 40Mpa; the extraction time is 4 hours; the CO2 fluid containing the dissolved extract is depressurized by a pressure reducing valve and enters a separation kettle, the solubility of the solute is greatly reduced, so that the solute is separated out, and the extract can be obtained by concentrating the solute to dryness under reduced pressure.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) To the mixture in step 2) were added 0.6 parts of acetyl tetrapeptide-5, 1.4 parts of lactic acid bacteria fermentation lysate, 1.2 parts of nicotinamide, 1.2 parts of Fucus vesiculosus extract.
4) Continuously adding an emollient, a filler, a preservative and a pH regulator into the mixed solution in the step 3), heating to 65 ℃, and homogenizing for 3 minutes at 3000r/min to enable the mixture to be completely dispersed;
5) Adding emulsifying agent and daily essence into the step 4), homogenizing for 3 min at 3000r/min to completely emulsify, and heating to 65deg.C to obtain essence emulsion composition with effects of removing black eye and eye pouch, wherein pH is 6.0-6.7.
The preparation process of the essence emulsion with the efficacy of removing dark circles and bags of eyes of the embodiment 3 comprises the following steps:
1) Preparation of lactic acid bacteria fermentation lysate:
lactobacillus species were used at 1:10, performing expansion culture in a seed culture medium; lactobacillus amplified at 1: inoculating the fermentation culture in a volume ratio of 10 to a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotating speed of the shaking table is 150r/min, and the fermentation time is 12h; performing ultrasonic treatment on the fermentation broth by using a cell ultrasonic pulverizer for 30min, centrifuging at a centrifugal speed of 10000r/min, taking supernatant, and removing filter residues; and (3) performing high-temperature sterilization on the obtained supernatant, wherein the sterilization temperature is 95 ℃, and the sterilization time is 30min, so as to obtain the lactobacillus fermentation lysate.
Preparation of Fucus vesiculosus extract:
cleaning 100g of raw materials, drying, crushing, and sieving with a 60-mesh sieve to obtain raw material powder for later use; the method comprises the steps of (1) loading raw material powder into a supercritical extraction kettle, allowing CO2 to enter from the bottom of the extraction kettle after pressure and temperature adjustment, adding a small amount of entrainer acetone into the supercritical CO2 in a liquid form, fully contacting the raw material powder, and selectively dissolving out required chemical components; the extraction temperature is 45 ℃; the extraction pressure is 40Mpa; the extraction time is 8 hours; the CO2 fluid containing the dissolved extract is depressurized by a pressure reducing valve and enters a separation kettle, the solubility of the solute is greatly reduced, so that the solute is separated out, and the extract can be obtained by concentrating the solute to dryness under reduced pressure.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) To the mixture in step 2) were added 0.8 parts of acetyl tetrapeptide-5, 1.8 parts of lactic acid bacteria fermentation lysate, 1.6 parts of nicotinamide, 0.8 parts of Fucus vesiculosus extract.
4) Continuously adding an emollient, a filler, a preservative and a pH regulator into the mixed solution in the step 3), heating to 65 ℃, and homogenizing for 3 minutes at 3000r/min to enable the mixture to be completely dispersed;
5) Adding emulsifying agent and daily essence into the step 4), homogenizing for 3 min at 3000r/min to completely emulsify, and heating to 65deg.C to obtain essence emulsion composition with effects of removing black eye and eye pouch, wherein pH is 6.0-6.5.
Effect verification test example
1. Safety test
Test sample: example 1;
the testing method comprises the following steps: and testing the security by adopting a third party detection mechanism. A suitable patch device with an area of not more than 50mm2 and a depth of about 1mm is selected, and about 0.02-0.025ml (g) of a test object is added into the patch device by a closed patch test method. The patch tester is attached to the forearm of a subject, the test object is removed after 24 hours, the skin reaction is observed after 0.5 hour, 24 hours and 48 hours respectively, and the result is recorded according to the skin reaction grading standard in cosmetic safety technical regulations 2015.
TABLE 2 Patch test results
Remarks: skin response grading criteria;
level 0: a negative reaction;
stage 1: suspicious reactions; only weak erythema;
2 stages: weak positive response (erythema response); erythema, infiltration, edema, and possibly papules;
3 stages: strong positive response (herpes response); erythema, infiltration, edema, papules, herpes; the reaction may be beyond the test zone;
4 stages: extremely strong reactions (fusogenic herpetic reactions); obvious erythema, severe infiltration, edema, blepharospermia, and response beyond the test area.
As can be seen from table 2 above, the prepared essence milk showed no irritation and was safe.
2. Stability test
Test sample: example 1;
the testing method comprises the following steps: internal control standard, the appearance color, viscosity, pH for three months was observed.
TABLE 3 stability investigation results
As shown in the table 3, the prepared essence emulsion has no obvious change in color, viscosity and pH within three months under the conditions of high and low temperature or illumination, which proves that the essence emulsion has better stability.
3. Efficacy test of compositions for removing dark under-eye and under-eye puffiness
Test sample: the anti-dark under-eye and under-eye pouch efficacy composition of example 1 (0.4% acetyl tetrapeptide-5, 1% lactic acid bacteria fermentation lysate, 0.8% nicotinamide, 0.8% Fucus vesiculosus extract)
The testing method comprises the following steps:
1) A0.01% combined bilirubin solution was mixed with 10mg/mL of the anti-black eye and pouch efficacy composition in a light-protected tube and allowed to stand for 24 hours. Bilirubin levels are measured by High Pressure Liquid Chromatography (HPLC) to measure the ability of the composition to lighten dark circles.
2) Human preadipocytes were cultured for 8 days in the presence of 0.005 or 0.01mg/mL of the anti-black eye and pouch efficacy composition. Comparison was made with 0.2mg/mL caffeine. Fat accumulation was measured by fluorescence techniques stained with nile red to measure the ability of the combination to improve the pouch.
Test results:
1) From the experimental results fig. 1, it can be seen that the bilirubin content can be reduced by about 18.5% after 24 hours of mixing the test sample with the combined bilirubin solution, indicating that the test sample is effective in reducing dark circles.
2) From the experimental results, as shown in FIG. 2, the 0.005mg/mL sample was effective in reducing fat accumulation by 15.7; a0.01 mg/mL sample was effective in reducing fat accumulation by 24.4%, indicating that the present test sample was effective in reducing fat accumulation, thereby improving a fatty pouch.
4. Evaluation of effect of removing dark under eye and pouch
Test sample: example 1;
the testing method comprises the following steps: twice daily, in the morning and evening. A suitable amount of test sample was applied around the eye on one side of the randomization and no test sample was used on the other side as a control. The sunscreen product is applied to the whole face daily in the morning.
The results were tested in the following 4 time periods, respectively: before the sample (D0), after 14 days of the sample (D14), after 28 days of the sample (D28), and after 56 days of the sample (D56).
The detection items are as follows:
the VISIA-CR is used for facial image acquisition and skin color analysis;
primos is used for facial image acquisition and pouch analysis;
the skin color meter CL400 is for detecting skin color;
the skin melanin and red pigment tester MX18 is used for detecting skin melanin and skin heme;
test results:
as shown in fig. 3-7, tables 4-8, the results of the clinical efficacy test experiment of example 1, after 56 days of use (D56): the skin color L+ value of the sample area is obviously increased by 2.35 percent; the analysis value of the eye pouch volume of the sample area is obviously reduced by 8.74 percent; the skin color ITA DEG value of the sample area is remarkably increased by 5.84%; the skin melanin value of the sample area is obviously reduced by 3.61%; the skin red pigment value of the sample area is remarkably reduced by 3.61 percent.
TABLE 4 rate of change of skin color L
| Time | After 14 days of use (D14) | After 28 days of use (D28) | After 56 days of use (D56) |
| Sample of | 0.31％ | 0.76％ | 2.35％ |
| Control | -1.31％ | -1.18％ | -0.46％ |
TABLE 5 pouch volume change rate
| Time | After 14 days of use (D14) | After 28 days of use (D28) | After 56 days of use (D56) |
| Sample of | -5.07％ | -8.62％ | -8.74％ |
| Control | 1.86％ | 3.05％ | 2.94％ |
TABLE 6 skin color ITA change Rate
| Time | After 14 days of use (D14) | After 28 days of use (D28) | After 56 days of use (D56) |
| Sample of | 4.02％ | 3.26％ | 5.84％ |
| Control | -0.29％ | -0.71％ | -1.5％ |
TABLE 7 skin melanin rate of change
| Time | After 14 days of use (D14) | After 28 days of use (D28) | After 56 days of use (D56) |
| Sample of | -3.81％ | -3.37％ | -3.61％ |
| Control | 3.82％ | 2.97％ | 5.65％ |
TABLE 8 skin Reddish Rate of change
| Time | After 14 days of use (D14) | After 28 days of use (D28) | After 56 days of use (D56) |
| Sample of | -3.81％ | -3.04％ | -3.61％ |
| Control | -1.01％ | -0.12％ | 5.23％ |
In conclusion, the essence emulsion composition with the effects of removing dark circles and the eye bags, which is prepared by the embodiment of the invention, can effectively lighten dark circles on eyes and improve the problems of the eye bags and the skin around eyes.
5. Synergistic test of dark circles removing and pouch removing composition
An essence emulsion composition with effects of removing black eye and pouch comprises the raw materials of comparative examples 1-14 in proportion as shown in the following tables 9-10.
Table 9 Table 1-7 shows the ratios of the components of the dark under-eye and under-eye bag-removed essence milk (unit: mass%)
Table 10 comparative examples 8 to 14 were conducted on the ratio table (unit: mass%) of the dark under eye and under eye bag removed essence milk components
The preparation process of the essence milk with the functions of removing dark circles and bags of eyes of comparative examples 1 to 14 comprises the following steps:
1) Preparation of lactic acid bacteria lysate:
bifidobacterium species were isolated at 1:5, performing expansion culture in a seed culture medium according to the volume ratio; spread bifidobacteria were grown at 1: inoculating the fermentation culture in a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotation speed of the shaking table is 100r/min, and the fermentation time is 12h; performing ultrasonic treatment on the fermentation broth by using a cell ultrasonic pulverizer for 30min, centrifuging at a centrifugal speed of 10000r/min, taking supernatant, and removing filter residues; and (3) performing high-temperature sterilization on the obtained supernatant, wherein the sterilization temperature is 95 ℃, and the sterilization time is 30min, so as to obtain the lactobacillus fermentation lysate.
Preparation of Fucus vesiculosus extract:
cleaning 20g of raw materials, drying, crushing, and sieving with a 80-mesh sieve to obtain raw material powder for later use; the method comprises the steps of (1) loading raw material powder into a supercritical extraction kettle, allowing CO2 to enter from the bottom of the extraction kettle after pressure and temperature adjustment, adding a small amount of entrainer acetone into the supercritical CO2 in a liquid form, fully contacting the raw material powder, and selectively dissolving out required chemical components; the extraction temperature is 45 ℃; the extraction pressure is 40Mpa; the extraction time is 2 hours; the CO2 fluid containing the dissolved extract is depressurized by a pressure reducing valve and enters a separation kettle, the solubility of the solute is greatly reduced, so that the solute is separated out, and the extract can be obtained by concentrating the solute to dryness under reduced pressure.
2) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
3) Adding the functional components for removing dark circles and bags, the emollient, the filler, the preservative and the pH regulator into the mixed solution in the step 1), heating to 65 ℃, homogenizing for 3 minutes at 3000r/min to ensure that the functional components are completely dispersed;
4) Adding the emulsifying agent and the daily essence into the step 2), homogenizing for 3 minutes at 3000r/min to completely emulsify, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of removing dark circles and eye bags.
The effect of the synergistic test of the components for removing dark under eye and under eye puffiness was verified in examples and comparative examples 1 to 14, and the procedure and results are as follows:
1) The tester: 150 healthy females (20-45 years old) divided into 15 groups of 10 individuals each; the same formulation was used within the group.
2) Test area: the periocular region.
3) The method comprises the following steps: twice daily, in the morning and evening. A suitable amount of test sample was applied around the eye on one side of the randomization and no test sample was used on the other side.
The results were tested in the following 4 time periods, respectively: before the sample (D0), after 14 days of the sample (D14), after 28 days of the sample (D28), and after 56 days of the sample (D56).
4) Test items:
the VISIA-CR is used for facial image acquisition and skin color analysis;
primos is used for facial image acquisition and pouch analysis;
the skin color meter CL400 is for detecting skin color;
5) The test results are shown in Table 11.
Table 11 test set effect
From the results shown in Table 11, FIGS. 8 to 10, it can be seen that when acetyl tetrapeptide-5, lactic acid bacteria fermentation lysate and nicotinamide are added to the essence milk at the same time, the dark circles can be effectively reduced, the skin eye bags can be improved, and the effect is remarkably improved compared with the effect obtained by using only one component or two components.
This shows that the combination of acetyl tetrapeptide-5, lactobacillus fermentation lysate and nicotinamide can act on most of black eye types and effectively reduce eye bags, and is an excellent cosmetic formula for improving eye appearance and improving color value.
The present invention is not limited to the preferred embodiments, but can be modified, equivalent, and modified in any way without departing from the technical scope of the present invention.
Claims (9)
1. An essence emulsion composition with the efficacy of removing dark circles and eye bags is characterized in that: comprises 0.5-35% of functional components for removing black eye and eye bags and 65-99.5% of cosmetic auxiliary material matrix by total weight of the composition; the functional components for removing dark circles and the pouch comprise: acetyl tetrapeptide-5, lactobacillus fermentation lysate, nicotinamide, fucus serrulata extract;
0.5-35% of an effective component for removing dark circles and under-eye puffiness, comprising: 0.1-10% of acetyl tetrapeptide-5, 0.1-8% of lactobacillus fermentation lysate, 0.1-10% of nicotinamide, 0.1-12% of Fucus vesiculosus extract;
the mass ratio of the acetyl tetrapeptide-5, the lactobacillus fermentation lysate, the nicotinamide and the fucus serrulata extract is 1 based on the total weight of the composition: (2-5): (1-4): (1-2).
2. The essence emulsion composition having the efficacy of removing dark circles and under-eye puffiness according to claim 1, characterized in that: the cosmetic auxiliary material matrix consists of an emollient, an emulsifier, a filler, a thickener, a preservative, a pH regulator, a daily essence and deionized water.
3. The essence emulsion composition with the efficacy of removing dark circles and under-eye puffiness according to claim 1, which is composed of the following components by weight of the total composition:
0.5-35% of an effective component for removing dark circles and under-eye puffiness, comprising: 0.1-10% of acetyl tetrapeptide-5, 0.1-8% of lactobacillus fermentation lysate, 0.1-10% of nicotinamide, 0.1-12% of Fucus vesiculosus extract;
65-99.5% of a cosmetic adjuvant matrix comprising: 0.5-40% emollient; 1-20% of an emulsifier; 0.5-25% filler; 0.5-20% of a thickener; 0.1-10% preservative; 0.01-5% of a pH regulator; 0.001-4% of daily essence; the balance of deionized water.
4. The essence emulsion composition with the efficacy of removing dark circles and under-eye puffiness according to claim 1, which is composed of the following components by weight of the total composition:
1-15% of an effective component for removing dark circles and under-eye puffiness, which comprises: 0.2-4% of acetyl tetrapeptide-5, 0.1-5% of lactobacillus fermentation lysate, 0.5-5% of nicotinamide, 0.1-4% of Fucus vesiculosus extract;
85-99% of a cosmetic adjuvant matrix comprising: 5-35% of an emollient; 1-15% of an emulsifier; 1-20% of a filler; 1-15% of a thickener; 0.1-5% preservative; 0.01-4% of a pH regulator; 0.001-2% of daily essence; the balance of deionized water.
5. The essence emulsion composition with the efficacy of removing dark circles and under-eye puffiness according to any one of claims 1 to 4, wherein the preparation method of the lactobacillus fermentation lysate comprises the following steps:
1) Lactobacillus species were used at 1: performing expansion culture in a seed culture medium according to the volume ratio of (5-10);
2) The lactic acid bacteria amplified in step 1) were treated with 1: inoculating the mixture to fermentation culture in a constant temperature shaking table for fermentation to obtain fermentation liquor; the fermentation temperature is 37 ℃, the rotation speed of the shaking table is 50-200r/min, and the fermentation time is 5-12h;
3) Performing ultrasonic treatment on the fermentation broth obtained in the step 2) for 10-30min by using a cell ultrasonic pulverizer, centrifuging at a centrifugal speed of 10000r/min, taking supernatant and removing filter residues;
4) And 3) performing high-temperature sterilization on the supernatant obtained in the step 3), wherein the sterilization temperature is 95 ℃, and the sterilization time is 10-30min, so as to obtain the lactobacillus fermentation lysate.
6. The essence emulsion composition having the efficacy of removing dark under eye circles and under eye puffiness of claim 5, wherein: the lactobacillus strain is selected from one or two of bifidobacteria and lactobacillus; the lactobacillus fermentation lysate is rich in lactobacillus cell active ingredients including peptidoglycan, extracellular polysaccharide, active peptide and amino acid.
7. The essence emulsion composition having the efficacy of removing dark circles and under-eye puffiness according to claim 1, characterized in that: the emollient is selected from one or more of butanediol, hexanediol, stearyl alcohol, behenyl alcohol, caprylic glycol, caprylic capric triglyceride, squalane, avocado oil, soybean oil, shea butter, rapeseed oil, jojoba oil, hydrogenated polyisobutene, isododecane, phytosterol, polydecene, isononyl isononanoate;
the emulsifier is one or more selected from polysorbate-20, sorbitan olive oleate, stearyl alcohol polyether-21, polysorbate-80, soybean lecithin PC60, glycerol stearate, laureth-23 and poloxamer 407;
the filler is one or more selected from boron nitride, volcanic ash, diatomite, mica, kaolin, talcum powder, starch octyl aluminum succinate and cellulose acetate;
the thickener is one or more selected from glycerol, 1, 3-propylene glycol, carbomer, xanthan gum, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, gum arabic, hydroxyethyl cellulose, polymer EMT-10, sodium acrylate/sodium acryloyldimethyl taurate and acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer copolymer;
the pH regulator is one or two of lactic acid and arginine.
8. The process for producing an essential emulsion composition having an efficacy of removing dark under-eye circles and under-eye puffiness as claimed in any one of claims 1 to 7, characterized in that: the method comprises the following steps:
1) Wetting and dispersing the thickener in water completely to obtain a mixed solution;
2) Adding the functional components for removing dark circles and bags, the emollient, the filler, the preservative and the pH regulator into the mixed solution in the step 1), heating to 65 ℃, homogenizing for 3 minutes at 3000r/min to ensure that the functional components are completely dispersed;
3) Adding the emulsifying agent and the daily essence into the step 2), homogenizing for 3 minutes at 3000r/min to completely emulsify, and heating to 65 ℃ to obtain the essence emulsion composition with the effects of removing dark circles and eye bags.
9. A cosmetic product characterized by: the cosmetic comprises the essence emulsion composition with the efficacy of removing dark circles and bags, which is prepared by the preparation method of claim 8.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478459A (en) * | 2018-04-28 | 2018-09-04 | 广东巴松那生物科技有限公司 | A kind of eye essence of the lysate containing lactobacillus fermentation and preparation method thereof |
| CN110464658A (en) * | 2019-08-07 | 2019-11-19 | 广州艾蓓生物科技有限公司 | A kind of multiple-effect eye freeze-drying film and steam eye patch |
| CN110742831A (en) * | 2019-10-29 | 2020-02-04 | 浙江英树生物科技有限公司 | Brightening eye brightening and night-out eye mask essence and preparation method thereof |
| CN112494384A (en) * | 2020-12-09 | 2021-03-16 | 珠海为你而美丽化妆品有限公司 | Composition for removing dark eye circles, eye mask and preparation method of eye mask |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478459A (en) * | 2018-04-28 | 2018-09-04 | 广东巴松那生物科技有限公司 | A kind of eye essence of the lysate containing lactobacillus fermentation and preparation method thereof |
| CN110464658A (en) * | 2019-08-07 | 2019-11-19 | 广州艾蓓生物科技有限公司 | A kind of multiple-effect eye freeze-drying film and steam eye patch |
| CN110742831A (en) * | 2019-10-29 | 2020-02-04 | 浙江英树生物科技有限公司 | Brightening eye brightening and night-out eye mask essence and preparation method thereof |
| CN112494384A (en) * | 2020-12-09 | 2021-03-16 | 珠海为你而美丽化妆品有限公司 | Composition for removing dark eye circles, eye mask and preparation method of eye mask |
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