CN113769018A - 一种治疗痛风的中药组合物及其制备方法 - Google Patents
一种治疗痛风的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗痛风的中药组合物及其制备方法;所述组合物包括杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参和醋。制备时,称量杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器中;加入醋浸泡,浸泡15‑20天;过滤,滤液灌装。本发明的配方中用精致米醋做药引子,纯中药炮制,通过控制特定pH值,米醋能在一定温度下,提炼各药材活性成分,实现补血养气、排毒散结、消炎去肿、软化血管、调节内分泌、提高机体免疫力、以及尿酸值逐步降至正常水平,且无副作用。
Description
技术领域
本发明属于中医药技术领域,涉及一种治疗痛风的中药组合物及其制备方法。
背景技术
痛风又称“高尿酸血症”,嘌呤代谢障碍,属于关节炎一种。痛风是体内嘌呤的物质的新陈代谢发生紊乱,尿酸的合成增加或排出减少,造成高尿酸血症,血尿酸浓度过高时,尿酸以钠盐的形式沉积在关节、软骨和肾脏中,引起组织异物炎性反应,即痛风,一般发作部分为大拇指关节、踝关节、膝关节等。急性痛风发作部位出现红、肿、热、剧烈疼痛,一般多在子夜发作,可使人从睡眠中惊醒,痛风初期,发作多见于下肢。
目前对于痛风,西医治疗主要应用秋水仙碱、别嘌呤醇、非甾体类抗炎药、激素等药物治疗,虽可较快控制急性症状,但因其副作用大,患者往往难以坚持治疗,故复发率很高。
当前西医治痛风主要还存在以下问题:1、治痛风不等于止痛:仅仅急性发作期止痛,疼痛缓解或进入无症状期,就不管不顾,会导致痛风病情反复发作。2、单一降尿酸治标不治本:痛风发病,肾脏功能衰竭,肾脏不能正常代谢尿酸,体内沉积的尿酸盐结晶未清除。3、长期依赖止痛药:大量服用西药激素会对关节造成极大损伤,最后可能会出现关节残疾、肾功能不全,尿毒症。
在中医中,痛风属于“痹症”的范畴,又称“历节“、”白虎历节风”等。痛风的病因病机主要以湿、热、寒、痰、瘀、虚六个方面,可从病因、气血津液和脏腑辨证三个方面对其进行中医辨证;中医辨证主要分为湿热蕴结型、寒湿痹阻型、痰浊阻滞型、脾虚湿阻型和肝肾阴虚型五种类型。因此,当痛风发作时,辨证服用中药,可以有效地缓解痛风引起的关节肿痛等症状。比如补肝益肾、活血清利的中药,健脾益肾、温阳散寒的中药,化痰散结、活血通络的中药,清热祛风、通络利湿的中药,清热利尿、通淋排石的中药等。具体来说:肝肾阴虚型的痛风,会伴随着眼睛干涩、关节疼痛、手心脚心发热、发烧盗汗、便秘、血尿等症状,此时可以应用补肝益肾、活血清利的中药辨证治疗,通过滋补肝肾缓解病情。脾肾气虚型的痛风会出现气短乏力、四肢冰凉、恶心腹胀、足跟疼痛等不适症状,此时可以应用健脾益肾、温阳散寒的中药调理,改善脾肾气虚症状,也能很好的缓解痛风病情。痰瘀阻滞型的痛风会出现关节肿痛、局部畸形发红、脸色发黄、浑身无力等症状,抽取关节液时还能发现痛风石。此时可以服用化痰散结、活血通络的中药治疗,改善痰瘀阻滞症状,也能很好的缓解痛风病情。风湿热痹型的痛风会伴随着发烧、怕风、关节肿痛、尿频、尿痛、尿少等不适症状,此时可以应用清热祛风、通络利湿的中药进行治疗,也可以缓解病情。此外,对痛风患者来说,如果能减少因痛风引起的血热血燥,增加尿量的排出,降低血尿酸的浓度,就可以缓解病情。所以出现痛风时,也可以应用清热利尿的中药治疗,减少尿酸在关节处的沉积,缓解关节疼痛症状。进一步的,痛风患者关节处会有疼痛症状,与痛风石的反复刺激有一定的关系,如果能适当的服用一些通淋排石的药物,促使痛风石溶解、排出,也可以缓解疼痛症状。
发明内容
本发明的目的在于提供一种治疗痛风的中药组合物及其制备方法;该中药配方源于发明人祖传中草药秘方(也称顺和口服液、痛风灵),且经几代人多年验证,对于中医辨证的各类型痛风都能够有效地缓解痛风引起的关节肿痛等症状,并在一定程度上实现根治痛风。
本发明的目的是通过以下技术方案来实现的:
本发明涉及一种治疗痛风的中药组合物,包括杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参和醋。
本发明中,选用的西洋参为加拿大或美国产西洋参。西洋参是五加科人参属多年生草本植物,别名花旗参、洋参、西洋人参,原产于加拿大的大魁北克与美国的威斯康辛州,中国北京怀柔与长白山等地也有种植。在本发明的配方中,如采用国产西洋参将达不到功效。黄芪需要为至少3年生的黄芪。醋必须为米醋,而不能使用香醋。
本发明配方中各中药组成详细情况如下:
杜仲:药用杜仲,即为杜仲科植物杜仲的干燥树皮,是中国名贵滋补药材。其味甘,性温。有补益肝肾、强筋壮骨、调理冲任、固经安胎的功效。可治疗肾阳虚引起的腰腿痛或酸软无力,肝气虚引起的胞胎不固,阴囊湿痒等症。在《神农本草经》中被列为上品。
黄芪:补中益气、性味归经、利水消肿;可治疗早期糖尿病;
党参:性味归经、补中益气、生津;主治:脾胃虚弱、气血两亏;
白术:为菊科植物,白术的根茎治疗脾胃气弱、倦急少气,有利尿降血糖作用以及抗菌作用;
当归:补气活血、调经止痛、治风湿痹痛、抗缺氧、调节机体免疫力、抗动脉硬化;
白花蛇舌草:清湿解毒、利湿、对单核细胞型以及慢性核细胞型的肿瘤细胞有较强抑制作用;
麦冬:养阴清热、润肺止咳、抗实冷性心律失常、养阴生津、润肺清心;
西洋参:补气养阴、促进血液活力、提高机体免疫力,降血糖、抗疲劳、抗氧化,对气虚阴亏。
所述中药组合物中各药材的重量份数如下:杜仲45-55份、黄芪35-45份、党参5-10份、白术3-8份、当归5-10份、麦冬20-30份、白花蛇舌草110-130份、西洋参75-85份。
作为一个优选方案,所述中药组合物中各药材的重量份数如下:杜仲50份、黄芪40份、党参8份、白术5份、当归8份、麦冬25份、白花蛇舌草120份、西洋参80份。
本发明中,醋的用量为每克药材添加醋20-28ml。
本发明还涉及治疗痛风的中药组合物的制备方法,所述方法包括如下步骤:
S1、称量杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器中;
S2、加入醋浸泡,浸泡温度控制在40-65℃,浸泡时间为15-20天;
S3、过滤,滤液灌装。
本发明的制备工艺,添加的醋为pH4-5.5的米醋。
本发明的制备工艺,浸泡过程中,每天必须早、晚各搅拌一次。上下搅拌,使得药材受热均匀即可。
本发明的制备工艺中,步骤S1中的容器,以及存放器具、灌装容器等均不得含有重金属。
本发明的制备工艺中,过滤采用离心机加纱布袋来进行过滤。
本发明的制备工艺中,步骤S1中的药材需进行筛选,不得有杂草、霉变、虫蛀等。
与现有技术相比,本发明具有如下有益效果:
1)本发明的配方用精致米醋做药引子,纯中药炮制,通过控制特定pH值,米醋能在一定温度下,提炼各药材活性成分,实现补血养气、排毒散结、消炎去肿、软化血管、调节内分泌、提高机体免疫力、以及尿酸值逐步降至正常水平,且无副作用。
2)本发明的组合物为棕褐色口服液,微酸,推荐服用周期为两个疗程(一个疗程6瓶250ml);对100个患者统计,95%痛风患者,未见复发,且生活质量提高,豆制品和海鲜可适量食用;5%患者因未遵从禁忌要求,出现痛风预兆(如服用动物内脏(猪肝)引发脚趾头出现痛风征兆),经再次服用本发明的组合物后恢复正常。
具体实施方式
下面结合实施例对本发明进行详细说明。以下实施例将有助于本领域的技术人员进一步理解本发明,但不以任何形式限制本发明。应当指出的是,对本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干调整和改进。这些都属于本发明的保护范围。
实施例1
本实施例涉及一种治疗痛风的中药的组合物;一贴药剂的配方为:杜仲45克、黄芪35克、党参5克、白术3克、当归5克、麦冬20克、白花蛇舌草110克、西洋参75克;
制备工艺如下:
1)对杜仲、3年生黄芪、党参、白术、当归、麦冬、白花蛇舌草、加拿大西洋参等药材进行筛选,不得有杂草、霉变、虫蛀;
2)称量筛选好的杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器(该容器中不得含重金属)中;
3)加入pH值为4-5.5的米醋7公升,将容器放入低温鼓风干燥箱控制在45℃进行浸泡,浸泡18天,期间每天早、晚各搅拌一次;
4)采用离心机加纱布袋来对浸泡物料进行过滤;
5)将5贴中药过滤液合并、浓缩于250ml,灌装后得产品。本品为棕褐色口服液,微酸。推荐服用周期为两个疗程,一个疗程6瓶250ml,口服每次25ml,早晚各一次,饭后服用。
实施例2
本实施例涉及一种治疗痛风的中药的组合物;一贴药剂的配方为:杜仲55克、黄芪55克、党参10克、白术8克、当归10克、麦冬30克、白花蛇舌草130克、西洋参85克。
制备工艺如下:
3)对杜仲、3年生黄芪、党参、白术、当归、麦冬、白花蛇舌草、加拿大西洋参等药材进行筛选,不得有杂草、霉变、虫蛀;
4)称量筛选好的杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器(该容器中不得含重金属)中;
3)加入pH值为4-5.5的米醋9公升,将容器放入低温鼓风干燥箱控制在65℃进行浸泡,浸泡18天,期间每天早、晚各搅拌一次;
4)采用离心机加纱布袋来对浸泡物料进行过滤;
5)将5贴中药过滤液合并、浓缩于250ml,灌装后得产品。本品为棕褐色口服液,微酸。推荐服用周期为两个疗程,一个疗程6瓶250ml,口服每次25ml,早晚各一次,饭后服用。
实施例3
本实施例涉及一种治疗痛风的中药组合物;一贴药剂的配方为:杜仲50克、黄芪40克、党参8克、白术5克、当归8克、麦冬25克、白花蛇舌草120克、西洋参80克。
制备工艺如下:
5)对杜仲、3年生黄芪、党参、白术、当归、麦冬、白花蛇舌草、加拿大西洋参等药材进行筛选,不得有杂草、霉变、虫蛀;
6)称量筛选好的杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器(该容器中不得含重金属)中;
3)加入pH值为4-5.5的米醋8公升,将容器放入低温鼓风干燥箱控制在60℃左右进行浸泡,浸泡18天,期间每天早、晚各搅拌一次;
4)采用离心机加纱布袋来对浸泡物料进行过滤;
5)将5贴中药过滤液合并、浓缩于250ml,灌装后得产品。本品为棕褐色口服液,微酸。推荐服用周期为两个疗程,一个疗程6瓶250ml,口服每次25ml,早晚各一次,饭后服用。
发明人将本实施例的配方产品送至上海旭太生物工程有限公司,结果如表1、表2所示:
表1
表2
可见,本发明提供的药剂稳定性佳。进一步评价本实施例的药剂疗效如下:
疗效标准参照《中医病症诊断疗效标准》评定,治愈:关节红肿热痛消退,局部无明显异常,活动自如,10个月左右尿酸值降至正常范围(如快速降尿酸值会反弹);好转:关节红肿热痛减轻,尿酸值下降,但未达到正常范围;未愈:关节红肿热痛症改善不明显,活动受限,尿酸值不下降。对100个患者统计,服用本品后,95%痛风患者,未见复发,且生活质量提高,豆制品和海鲜可适量食用;5%患者因未遵从禁忌要求,出现痛风预兆(如服用动物内脏(猪肝)引发脚趾头出现痛风征兆),经再次服用本发明的组合物后恢复正常。临床验证资料列举如下:
案例1,患者,男,上海市人,77岁,身份证号310109*********23X,2000年开始发痛风病,主要症状:化经常规治疗病情一直未见缓解,发病后期一月发作2次,化验尿酸值在560μmol/L以上。治疗现状:2006年服用二个疗程后,至今已有14年未发作;目前化验尿酸值在360μmol/L。
案例2,患者:李某,男,江苏省苏州市人,57岁,身份证号320524*********210,1990年开始发病,主要症状:化验尿酸值在600-700μmol/L,最多时每月发作2次,右脚大脚趾头红肿,后发展到膝盖红、肿、痛。治疗现状:2015年服用二个疗程后,至今未再发作,尿酸值降到430μmol/L,基本正常。
案例3,患者:陈某某,男,浙江省嘉兴市人,55岁,身份证号330411*********010,主要症状:化验尿酸值在680μmol/L,经常性发病,大脚趾红、肿、痛。治疗现状:2016年开始服用,服用了6瓶,服用后症状消失,至今未复发。
案例4,患者:沈某某,男,浙江省嘉兴市人,54岁,身份证号330411*********034,主要症状:化验尿酸值在700-750μmol/L,脚趾头红、肿,不能行走;最多时一个月发作一次。治疗现状:2016年10月份开始服用痛风灵,服用6瓶后症状好转,红肿消失。
案例5,患者:王某某,男,浙江省嘉善县人,45岁,身份证号330421*********015,主要症状:初诊化验尿酸值为800μmol/L,后有时还高出该值;发作时间从一年几次发展到一个月两次,不能行走。治疗现状:2014年服用4瓶后病情有很大好转,红肿消失;至今7年,未再复发。
案例6,患者:李某某,男,浙江省嘉善县人,36岁,身份证号330421*********039,主要症状:尿酸值高出正常指标,脚趾头红、肿,不能行走。治疗现状:2017年12月开始服药一个疗程后,至今未发作。
案例7,患者:孙某某,男,上海市人,41岁,身份证号310229*********214,主要症状:化验尿酸值在520μmol/L,脚大拇指红、肿、痛。治疗现状:2018年1月服药一个疗程后,至今未发作。
案例8,患者:孙某某,男,上海市人,66岁,身份证号310229*********215,主要症状:化验尿酸值在600μmol/L以上,11几年痛风病史,脚大拇指肿、痛。治疗现状:2018年元月服药一个疗程后,至今未发作。
案例9,患者:项某某,女,江苏省南通市人,42岁,身份证号320621*********966,主要症状:经常反复发作,有时一个月发作两次。治疗现状:2011年服药两个疗程后,至今10年未发作。
案例10,患者:杨某某,男,53岁,主要症状:脚大拇指红、肿、痛,经常反复发作,有时一个月发作两次。治疗现状:服用两个疗程后,2015年至今未发作。
此外,还需要强调的的是:本发明的配方用精致米醋做药引子(只加米醋不加水),纯中药炮制,通过控制特定pH值,米醋能在一定温度下,提炼各药材活性成分,最终实现有效地缓解痛风引起的关节肿痛等症状,并在一定程度上实现根治痛风的功效。该药引子是发明人祖传中草药秘方中的关键,曾用香醋替换米醋进行对比,除口感欠佳外,且患者服用后均未见好转。
以上对本发明的具体实施例进行了描述。需要理解的是,本发明并不局限于上述特定实施方式,本领域技术人员可以在权利要求的范围内做出各种变形或修改,这并不影响本发明的实质内容。
Claims (10)
1.一种治疗痛风的中药组合物,其特征在于,所述组合物包括杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参和醋。
2.根据权利要求1所述的治疗痛风的中药组合物,其特征在于,所述西洋参为加拿大或美国产西洋参。
3.根据权利要求1所述的治疗痛风的中药组合物,其特征在于,所述黄芪为至少3年生的黄芪。
4.根据权利要求1所述的治疗痛风的中药组合物,其特征在于,所述醋为米醋,pH值为4-5.5。
5.根据权利要求1所述的治疗痛风的中药组合物,其特征在于,所述中药组合物中各药材的重量份数如下:杜仲45-55份、黄芪35-45份、党参5-10份、白术3-8份、当归5-10份、麦冬20-30份、白花蛇舌草110-130份、西洋参75-85份;醋的用量为每克药材添加醋20-28ml。
6.一种根据权利要求1-5中任一项所述的治疗痛风的中药组合物的制备方法,其特征在于,所述方法包括如下步骤:
S1、称量杜仲、黄芪、党参、白术、当归、麦冬、白花蛇舌草、西洋参后置于容器中;
S2、加入醋浸泡,浸泡15-20天;
S3、过滤,滤液灌装。
7.根据权利要求6所述的治疗痛风的中药组合物的制备方法,其特征在于,步骤S2中,所述浸泡温度控制在40-65℃。
8.根据权利要求7所述的治疗痛风的中药组合物的制备方法,其特征在于,浸泡温度的控制是通过将容器放入低温鼓风干燥箱来实现的。
9.根据权利要求6所述的治疗痛风的中药组合物的制备方法,其特征在于,步骤S2的浸泡过程中,每天早、晚各搅拌一次。
10.根据权利要求6所述的治疗痛风的中药组合物的制备方法,其特征在于,步骤S3中,所述过滤采用离心机加纱布袋来进行过滤。
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