CN113740491A - Simulated skin for sensory evaluation and preparation method thereof - Google Patents
Simulated skin for sensory evaluation and preparation method thereof Download PDFInfo
- Publication number
- CN113740491A CN113740491A CN202110998539.0A CN202110998539A CN113740491A CN 113740491 A CN113740491 A CN 113740491A CN 202110998539 A CN202110998539 A CN 202110998539A CN 113740491 A CN113740491 A CN 113740491A
- Authority
- CN
- China
- Prior art keywords
- skin
- sensory evaluation
- parts
- simulated skin
- simulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001953 sensory effect Effects 0.000 title claims abstract description 158
- 238000011156 evaluation Methods 0.000 title claims abstract description 154
- 238000002360 preparation method Methods 0.000 title abstract description 25
- 150000002632 lipids Chemical class 0.000 claims abstract description 52
- 239000002344 surface layer Substances 0.000 claims abstract description 32
- 239000000758 substrate Substances 0.000 claims abstract description 28
- 239000011248 coating agent Substances 0.000 claims abstract description 19
- 238000000576 coating method Methods 0.000 claims abstract description 19
- 239000010410 layer Substances 0.000 claims description 52
- 239000011159 matrix material Substances 0.000 claims description 25
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 18
- 239000003995 emulsifying agent Substances 0.000 claims description 15
- 229920005749 polyurethane resin Polymers 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 14
- 239000000194 fatty acid Substances 0.000 claims description 14
- 229930195729 fatty acid Natural products 0.000 claims description 14
- 150000004665 fatty acids Chemical class 0.000 claims description 14
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 14
- 239000004164 Wax ester Substances 0.000 claims description 13
- 239000003963 antioxidant agent Substances 0.000 claims description 13
- 230000003078 antioxidant effect Effects 0.000 claims description 13
- 239000002649 leather substitute Substances 0.000 claims description 13
- 229920002635 polyurethane Polymers 0.000 claims description 13
- 239000004814 polyurethane Substances 0.000 claims description 13
- 239000011148 porous material Substances 0.000 claims description 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 13
- 235000019386 wax ester Nutrition 0.000 claims description 13
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 12
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 12
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 12
- 229940031439 squalene Drugs 0.000 claims description 12
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 11
- 235000012000 cholesterol Nutrition 0.000 claims description 10
- 239000002002 slurry Substances 0.000 claims description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical group CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 235000021314 Palmitic acid Nutrition 0.000 claims description 7
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 7
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 7
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 6
- 238000004049 embossing Methods 0.000 claims description 6
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 5
- 229940119170 jojoba wax Drugs 0.000 claims description 5
- 239000004745 nonwoven fabric Substances 0.000 claims description 5
- 229940042585 tocopherol acetate Drugs 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 3
- BVCOHOSEBKQIQD-UHFFFAOYSA-N 2-tert-butyl-6-methoxyphenol Chemical compound COC1=CC=CC(C(C)(C)C)=C1O BVCOHOSEBKQIQD-UHFFFAOYSA-N 0.000 claims description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 3
- DHFUFHYLYSCIJY-WSGIOKLISA-N CCCCCCCCCCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O Chemical compound CCCCCCCCCCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DHFUFHYLYSCIJY-WSGIOKLISA-N 0.000 claims description 3
- 239000005639 Lauric acid Substances 0.000 claims description 3
- 235000021360 Myristic acid Nutrition 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 claims description 3
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 claims description 3
- 235000013871 bee wax Nutrition 0.000 claims description 3
- 239000012166 beeswax Substances 0.000 claims description 3
- 239000004204 candelilla wax Substances 0.000 claims description 3
- 235000013868 candelilla wax Nutrition 0.000 claims description 3
- 229940073532 candelilla wax Drugs 0.000 claims description 3
- 239000004203 carnauba wax Substances 0.000 claims description 3
- 229940080421 coco glucoside Drugs 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 claims description 3
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 claims description 3
- 229940117972 triolein Drugs 0.000 claims description 3
- 241000381602 Vachellia nebrownii Species 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 243
- 238000012360 testing method Methods 0.000 abstract description 77
- 239000002537 cosmetic Substances 0.000 abstract description 70
- 230000000694 effects Effects 0.000 abstract description 22
- 239000004519 grease Substances 0.000 abstract description 9
- 210000002615 epidermis Anatomy 0.000 abstract description 7
- 239000012528 membrane Substances 0.000 abstract description 6
- 210000002374 sebum Anatomy 0.000 abstract description 4
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 208000026935 allergic disease Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 20
- 238000002474 experimental method Methods 0.000 description 20
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 18
- 238000012795 verification Methods 0.000 description 14
- 238000004088 simulation Methods 0.000 description 10
- 239000000203 mixture Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 206010070834 Sensitisation Diseases 0.000 description 5
- 239000003925 fat Substances 0.000 description 5
- 230000008313 sensitization Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 1
- 206010070835 Skin sensitisation Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 239000004234 Yellow 2G Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- RZUBARUFLYGOGC-MTHOTQAESA-L acid fuchsin Chemical group [Na+].[Na+].[O-]S(=O)(=O)C1=C(N)C(C)=CC(C(=C\2C=C(C(=[NH2+])C=C/2)S([O-])(=O)=O)\C=2C=C(C(N)=CC=2)S([O-])(=O)=O)=C1 RZUBARUFLYGOGC-MTHOTQAESA-L 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- FTZLWXQKVFFWLY-UHFFFAOYSA-L disodium;2,5-dichloro-4-[3-methyl-5-oxo-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazol-1-yl]benzenesulfonate Chemical compound [Na+].[Na+].CC1=NN(C=2C(=CC(=C(Cl)C=2)S([O-])(=O)=O)Cl)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 FTZLWXQKVFFWLY-UHFFFAOYSA-L 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- -1 trinononanoate Chemical compound 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
- 235000019235 yellow 2G Nutrition 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0001—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00 by organoleptic means
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
- A45D2044/007—Devices for determining the condition of hair or skin or for selecting the appropriate cosmetic or hair treatment
Abstract
The invention provides a simulated skin for sensory evaluation and a preparation method thereof. The simulated skin is provided with a substrate and a lipid surface layer coated on the surface of the substrate, simulates the epidermis structure and the sebum membrane structure of a real human body, and can replace the skin of the real human body to carry out cosmetic sensory evaluation test. The simulated skin can reduce the influence on the sensory evaluation test result caused by the skin state difference of different sensory evaluators, and can also reduce the potential risk that cosmetics may cause human allergy. Under the condition of not increasing the number of evaluators, the data of the sensory evaluation test effect are greatly enriched, the technical requirements of the sensory evaluation are fully met, and meanwhile, the labor cost is saved. The preparation method of the simulated skin for sensory evaluation comprises the step of coating grease on the surface of a substrate. The preparation method has simple steps and reasonable key step setting for simulating human skin, and can produce simulated skin products suitable for cosmetic sensory evaluation.
Description
Technical Field
The invention relates to the technical field of cosmetic sensory evaluation, in particular to simulated skin for sensory evaluation and a preparation method thereof.
Background
In the field of cosmetics, sensory evaluation is a method of directly coating a product to be tested on human skin and evaluating the sensory performance of the product by means of subjective feeling of a human body. Because the evaluation is carried out on the skin of the evaluator, the skin conditions of different individuals are different, and the skin area suitable for evaluation of each evaluator is limited, in order to achieve an accurate and effective sensory evaluation result, the evaluation times and the number of the evaluators need to be increased, so that the test time is prolonged, and the later data processing amount is large, so that the labor time cost is greatly increased. In addition, sensory evaluation requires that the product to be tested be applied to the surface of human skin for testing, increasing the risk of skin sensitization. The popularization and application of the sensory evaluation technology in the industry are influenced by the problems existing in the sensory evaluation of the cosmetics.
The existing bionic skin is multipurpose in the field of medical instruments and tissue engineering materials, namely, the bionic skin mainly helps to transfer nutrient substances and promotes healing of skin wounds and the like, does not relate to reconstruction of proportion of skin grains and water and oil, has large difference between water and oil distribution and elastic touch feeling of the skin and the real skin of a human body, and cannot be applied to sensory evaluation of cosmetic coating sensory experience. Even in the cosmetic field, the current application of biomimetic skin mainly focuses on the mechanism research of the efficacy of cosmetic raw materials acting on skin. The application only simulates the internal structure of the skin, researches the action mechanism of the cosmetic raw materials in the skin, and cannot be applied to the sensory evaluation of the coating cosmetics.
Therefore, it is necessary to provide a simulated skin for sensory evaluation and a preparation method thereof to overcome the deficiencies of the prior art.
Disclosure of Invention
It is an object of the present invention to avoid the disadvantages of the prior art and to provide a simulated skin for sensory evaluation. The simulated skin can truly simulate the epidermis structure and the sebum membrane structure of the real human skin, and can be used in cosmetic sensory evaluation as a substitute of a cosmetic sensory evaluation tool.
The above object of the present invention is achieved by the following technical measures.
The simulated skin for sensory evaluation is prepared by a process at least comprising a step of coating grease on the surface of a substrate, and is consistent with human skin.
Specifically, the simulated skin for sensory evaluation is provided with a substrate and a lipid surface layer coated on the surface of the substrate.
The substrate comprises a base layer and an elastic layer coated and solidified on the surface of the base layer, and the lipid surface layer is positioned on the surface of the elastic layer.
Specifically, the lipid surface layer comprises the following components in parts by weight: 5-100 parts of triglyceride, 1.5-40 parts of squalene, 0.6-20 parts of fatty acid and 5-200 parts of emulsifier.
Preferably, the lipid surface layer further comprises, in parts by weight: 2.5-50 parts of wax ester, 0.2-20 parts of cholesterol, 0.1-5 parts of antioxidant, 100-1000 parts of water and pH value regulator for regulating the pH value range of the simulated skin to 4.5-6.5.
More preferably, the lipid surface layer comprises, in parts by weight: 40-60 parts of triglyceride, 10-20 parts of squalene, 4.8-10 parts of fatty acid, 40-60 parts of emulsifier, 20-30 parts of wax ester, 1.6-5 parts of cholesterol, 1-5 parts of antioxidant and 500-1000 parts of water.
Preferably, the triglyceride is at least one of caprylic/capric triglyceride, trinononanoate and triolein;
the wax ester is at least one of jojoba oil, palm wax, candelilla wax, and beeswax;
the fatty acid is at least one of palmitic acid, lauric acid and myristic acid;
the antioxidant is at least one of tocopherol acetate, di-tert-butyl-p-cresol and tert-butyl hydroxyanisole;
the emulsifier is at least one of coco glucoside, cetearyl glucoside and arachidyl glucoside;
the pH regulator is lactic acid.
Preferably, the base layer is a spunlace nonwoven fabric, and the elastic layer is a polyurethane resin layer.
The simulated skin for sensory evaluation is provided with a substrate and a lipid surface layer coated on the surface of the substrate. The substrate of the simulated skin simulates the epidermis structure of a real human body, and the lipid surface layer on the surface of the substrate simulates the sebum membrane structure of the real human body. Compared with the bionic skin in the field of tissue engineering materials, the simulated skin can simulate the physical properties of the real human epidermis and can replace the real human skin to carry out cosmetic sensory evaluation tests. The simulated skin is used as a substitute for the real human skin in the sensory evaluation of the cosmetics, so that the influence on the sensory evaluation test result caused by the skin state difference of different sensory evaluators can be reduced, and the potential risk that the cosmetics possibly cause human allergy can be reduced.
Another object of the present invention is to provide a method for preparing a simulated skin for sensory evaluation, which avoids the disadvantages of the prior art. The preparation method is simple to operate, the key control steps are reasonably set, the simulated skin with stable performance and suitable for sensory evaluation can be produced in batches, and the production cost is low.
The above object of the present invention is achieved by the following technical measures.
Provides a preparation method of simulated skin for sensory evaluation. The preparation method comprises the step of coating grease on the surface of the substrate.
Specifically, the preparation method of the simulated skin for sensory evaluation comprises the following steps:
step one, preparing a substrate.
And secondly, coloring the matrix by simulating the skin color of the human body.
And step three, carrying out human pore texture imitation embossing on the colored matrix.
And step four, washing and drying the colored and embossed matrix to obtain the matrix simulating the skin complexion and the pore texture of the human body.
Step five, detecting whether the friction coefficient of the surface of the base body prepared in the step four is in a target friction coefficient range, and entering the step six when the detected friction coefficient is in the target friction coefficient range; and if not, changing the depth of the texture imitating human body pores on the embossing roller to re-emboss the matrix until the friction coefficient of the surface of the matrix meets the range of the target friction coefficient, and entering the sixth step.
And step six, coating a lipid surface layer on the surface of the elastic layer of the substrate with the friction coefficient meeting the requirement of the target friction coefficient range to obtain the finished product of the simulated skin.
Specifically, in the first step, the step of preparing the substrate includes:
the pre-prepared polyurethane resin slurry is uniformly coated on the base layer, and the slurry is rolled by an extrusion roller.
And (3) uniformly solidifying the slurry on the base layer through a water solidifying tank to obtain the unmodified polyurethane artificial leather.
Specifically, the target friction coefficient of the simulated skin for sensory evaluation ranges from 0.4 to 0.6.
The preparation method of the simulated skin for sensory evaluation comprises the step of coating grease on the surface of a substrate. The preparation method coats grease on the surface of the matrix with the adjusted pore lines, color and friction coefficient, and can simulate the epidermis structure and the sebum membrane structure of the real human skin. The preparation method has simple steps and reasonable key step setting for simulating human skin, and can produce simulated skin products suitable for cosmetic sensory evaluation.
Detailed Description
The invention is further illustrated by the following examples.
Example 1.
A simulated skin for sensory evaluation is prepared by a process at least comprising the step of coating grease simulating skin lipid on the surface of a substrate, and is the simulated skin consistent with human skin. The simulated skin for sensory evaluation is provided with a substrate and a lipid surface layer coated on the surface of the substrate. The base body comprises a base layer and an elastic layer coated and solidified on the base layer, and the lipid surface layer is positioned on the surface of the elastic layer.
The surface friction coefficient range of the simulated skin is 0.4-0.6, and the pH value range is 4.5-6.5. The simulated skin truly simulates the performances of skin color, lines, friction force, pH value, elastic touch feeling and the like of human skin, can be used for cosmetic sensory evaluation and can be used as a substitute of a cosmetic sensory evaluation tool.
The base layer of this embodiment may be a spunlace nonwoven. The spunlace nonwoven fabric is a product with a strong net structure formed by winding loose fiber nets mutually through a spunlace forming process. The spunlace nonwoven fabric is soft in texture, high in moisture absorption and quick moisture, high in fabric strength, washable, not easy to mildew and is a support with excellent performance.
The elastic layer of the present embodiment may be a polyurethane resin layer. The elastic layer comprises the following components in parts by weight: 85-115 parts of polyurethane resin, 15-35 parts of wood powder, 50-80 parts of dimethyl formamide (DMF) and 15-35 parts of toner. The elastic layer prepared by the proportion has soft texture and meets the performance requirement of human epidermis.
The simulated skin matrix part prepared by combining the base layer and the elastic layer has the characteristics of wear resistance and washing resistance. After being cleaned and re-coated with grease, the performance of the skin care product is consistent with that of the skin care product, and the skin care product can be circularly used in a cosmetic sensory evaluation test, so that the problem that the real human skin is easily in a fatigue state in the frequent cosmetic coating and cleaning processes is solved. Meanwhile, the sensitization risk of the cosmetics on the real human skin is reduced. In addition, the elastic layer made of the polyurethane resin also has moisture absorption, moisture permeability and elasticity, so that the absorption process of the real human skin to the cosmetics can be simulated after the simulated skin is contacted with the cosmetics.
The lipid surface layer comprises the following components in parts by weight: 5-100 parts of triglyceride, 1.5-40 parts of squalene, 0.6-20 parts of fatty acid and 5-200 parts of emulsifier. Preferably, the lipid facing further comprises: 2.5-50 parts of wax ester, 0.2-20 parts of cholesterol, 0.1-5 parts of antioxidant, 100-1000 parts of water and pH value regulator for regulating the pH value range of the simulated skin to 4.5-6.5.
Wherein the triglyceride can be at least one of caprylic/capric triglyceride, trinononanoate, and triolein. The wax ester is selected from at least one of jojoba oil, palm wax, candelilla wax, and beeswax. The fatty acid can be at least one of palmitic acid, lauric acid and myristic acid. The antioxidant can be at least one selected from tocopherol acetate, di-tert-butyl-p-cresol and tert-butyl hydroxy anisole. The emulsifier can be at least one of coco glucoside, cetearyl glucoside and arachidyl glucoside. The pH regulator can be lactic acid. The lipid surface layer in this embodiment can be prepared from commercially available raw materials, and those skilled in the art can select suitable raw materials according to actual needs, which are not listed here.
The lipid surface layer is a lipid simulating skin surface skin lipid of a real human body. The oil can adjust the water-oil distribution and the pH value of the surface of the substrate, so that the performance parameters are consistent with the real skin state of a human body.
The simulated skin for sensory evaluation is provided with a base layer, an elastic layer coated and solidified on the base layer and a lipid surface layer coated on the surface of the elastic layer. Wherein the spunlace nonwoven is used as a base layer for forming the support surface. The polyurethane resin is used as an elastic layer and is used for simulating skin color, lines, friction force and elastic touch of human skin. The lipid simulating the skin lipid on the surface of the human skin is used as a lipid surface layer for simulating the skin lipid film of the human skin. The base layer, the elastic layer and the lipid surface layer are sequentially laminated, so that the skin color, lines, friction force and elastic touch feeling of the real human skin can be simulated. Therefore, the simulated skin for sensory evaluation of the invention can be used for testing sensory evaluation indexes such as coating difficulty, whiteness, coverage, skin brightness, skin hand-sticking degree and the like after the cosmetics are applied to human skin. The sensory evaluation test effect of the simulated skin is close to the test effect of real human skin, the safety problems of fatigue caused by long-time sensory test on the human skin and sensitization risk brought to the human skin by cosmetics are avoided, and the simulated skin can be used as a substitute of the real human skin in the sensory test.
Example 2.
A simulated skin for sensory evaluation, the other structures and materials are the same as those of example 1, except that the lipid surface layer of this example comprises the following components in parts by weight: 40-60 parts of triglyceride, 10-20 parts of squalene, 4.8-10 parts of fatty acid, 40-60 parts of emulsifier, 20-30 parts of wax ester, 1.6-5 parts of cholesterol, 1-5 parts of antioxidant, 500-1000 parts of water and a pH value regulator for regulating the pH value of the simulated skin to be 4.5-6.5.
In the lipid surface layer of the embodiment, the proportion of the lipid simulating the skin lipid on the surface of the human skin is closer to the pH value and the water-oil distribution condition of the real human skin, and the accuracy of the cosmetic sensory evaluation test result is improved.
The simulated skin provided by the invention can be used as a cosmetic sensory evaluation tool to test sensory evaluation indexes such as coating difficulty, whiteness, coverage, skin brightness, skin hand-sticking degree and the like after the cosmetic is applied to human skin. The sensory evaluation test effect of the simulated skin is close to the test effect of the real skin, the safety problems of fatigue caused by long-time sensory test on human skin and sensitization risk brought to the human skin by cosmetics are avoided, and the simulated skin can be used as a substitute of a sensory test object.
Example 3.
A method for preparing a simulated skin for sensory evaluation as in example 1 or 2, comprising the step of applying an oil or fat simulating the skin lipids of the skin surface of a human body to the surface of the base.
The preparation method of the simulated skin for sensory evaluation specifically comprises the following steps:
step one, preparing a substrate. Specifically, pre-prepared polyurethane resin slurry is coated on a base layer, a slurry roller is thinned to be 0.1-0.3 mm in thickness through an extrusion roller, and the slurry is uniformly solidified on the base layer through a water solidifying tank to prepare the unmodified polyurethane artificial leather.
And secondly, coloring the matrix by simulating the skin color of the human body. Specifically, the toner is mixed into color paste according to the required skin color proportion, the temperature of the color paste is maintained between 45 ℃ and 50 ℃, and the color paste is coated on the polyurethane resin layer of the unmodified polyurethane artificial leather prepared in the step one through a roller.
And step three, carrying out human pore texture imitation embossing on the colored matrix. And specifically, drawing the colored polyurethane artificial leather obtained in the step two through a pattern roller with human pore texture imitation to obtain the polyurethane artificial leather with human skin pore texture imitation.
And step four, washing and drying the colored and embossed matrix to obtain the matrix simulating the skin complexion and the pore texture of the human body. And specifically, the colored and embossed polyurethane artificial leather prepared in the third step passes through a water washing tank, so that the solvent in the polyurethane artificial leather is replaced by water, and then a porous membrane is formed, and the polyurethane artificial leather is dried at 120 ℃ to finally form the polyurethane artificial leather simulating the skin color and pore texture of the human body.
Step five, detecting whether the friction coefficient of the surface of the base body prepared in the step four is in a target friction coefficient range, and entering the step six when the detected friction coefficient is in the target friction coefficient range; and if not, changing the depth of the texture imitating human body pores on the embossing roller to re-emboss the matrix until the friction coefficient of the surface of the matrix meets the range of the target friction coefficient, and entering the sixth step. The target friction coefficient is in the range of 0.4 to 0.6. The friction coefficient range truly simulates the friction index requirement of human skin.
And step six, coating grease simulating skin surface skin lipid of a human body on the surface of the elastic layer of the substrate with the friction coefficient meeting the requirement of the target friction coefficient range as a lipid surface layer to prepare the finished product simulated skin.
Aiming at the requirement of simulating the state of the real human skin, the key control point of the simulated skin preparation method of the embodiment lies in the toning of the substrate and the adjustment of the surface friction coefficient, so that the key parameters of the skin color, the grain, the friction coefficient and the like of the real human skin can be simulated, and an effective evaluation test tool substitute can be provided for cosmetic sensory evaluation.
The preparation method disclosed by the invention is simple to operate, reasonable in key control step setting, high in production efficiency, capable of producing simulated skin products for sensory evaluation with stable performance in batches and low in production cost. Because the quality and the performance of the finished product of the simulated skin are stable, the simulated skin prepared in the same batch is consistent in parameter indexes such as skin color, lines, friction force, pH value, elastic touch feeling and the like, and the problem of sensory evaluation test result error caused by individual difference of skin of an evaluator can be solved.
Because the test area of cosmetic sensory evaluation is not large, the simulated skin produced by the preparation method can be cut into sheets with smaller areas, and a large amount of the sheets are supplied for cosmetic sensory evaluation tests. Meanwhile, the preparation method of the invention has flexible and convenient control on the product performance, and can simulate the skin of different ages, races and parts. Under the condition of not increasing the number of evaluators, the data of the sensory evaluation test effect is greatly enriched, and the technical requirements of the sensory evaluation are fully met.
Example 4.
A simulated skin prepared using the method for preparing simulated skin for sensory evaluation of example 2, the other steps being the same as in example 2 except that:
in this example, the prepared elastic layer of the simulated skin comprises the following components in parts by weight: 100 parts of polyurethane resin, 25 parts of wood powder, 65 parts of Dimethylformamide (DMF) and 25 parts of toner.
In this embodiment, the first base layer is a water-jet non-woven fabric of a huahao brand, and the ratio of the viscose polyester is 3: 7.
In this embodiment, the pre-prepared polyurethane resin slurry in step one includes polyurethane resin (selected from htresin brand, model number Dolphin-1378, solid content 35 ± 2%), wood powder (selected from xingdong brand, extra white powder) and dimethylformamide (DMF for english, selected from wale changsheng brand, industrial grade, content is greater than or equal to 99%).
The thickness of the polyurethane resin layer prepared by the embodiment is about 0.2mm, and the average epidermal layer thickness in skin structures of human faces, limbs and the like is truly simulated. Therefore, the simulated skin prepared by the preparation method of the simulated skin can be used in a cosmetic sensory evaluation test, and can test index parameters such as the coating difficulty, the whiteness, the coverage degree, the skin brightness, the skin stickiness and the like through a skin test instrument after the cosmetic is applied to human skin.
In the embodiment, the second step is to mix red, yellow and white toners into color paste according to the mass ratio of 1:1:3, the temperature of the color paste is maintained between 45 ℃ and 50 ℃, and the color paste is coated on the polyurethane resin layer of the unmodified polyurethane artificial leather prepared in the first step through a roller. Wherein the red toner is acid fuchsin 6B (selected from Tianjin brand of China, Industrial grade), the yellow toner is acid bright yellow 2G (selected from Tianjin brand of China, Industrial grade), and the white toner is rutile titanium dioxide (selected from Shandong Jinpu brand of China, Industrial grade).
The toner composition and the proportion of the embodiment enable the prepared simulated skin to truly simulate the yellow-tone characteristic of the skin color band of Asian people. It should be noted that even asians have several differences in their skin color, such as those in the east asian region having a white hue and those in the south asian region having a dark yellow to brown hue. Those skilled in the art can prepare suitable skin color according to actual application, and the toner preparation ratio is not listed here. Similarly, if other skin colors need to be simulated, the toner can be mixed and blended according to actual needs.
The preparation method of the simulated skin for sensory evaluation has simple steps and stable quality of the finished product. The simulated skin prepared in the same batch is consistent in performance of parameters such as skin color, lines, friction force and elastic touch, and the problem of sensory evaluation test effect error caused by individual difference of skin of an evaluator can be solved.
Example 5.
The simulation skin and the real human skin of the invention are used for carrying out the comparative evaluation experiment of the cosmetic sense organ
Purpose of the experiment
The simulated skin and the real human skin of the invention are used as cosmetic sensory evaluation tools, and the differences of the sensory evaluation indexes such as the coating difficulty, the whiteness, the coverage degree, the skin brightness, the skin hand-sticking degree and the like are compared.
2 preparation of the experiment
This example produced simulated skin samples 1 through 9 using the method of example 4. The other structures and materials of the 9 samples were the same as those of example 1, except that the samples were different1 to 9, oils and fats as lipid surface layers were prepared in the ratios shown in table 1. In this example, the triglyceride was caprylic/capric triglyceride (British Poa brand, cosmetic grade, content ≥ 99%), the wax ester was jojoba oil (Jiangxibolin brand, cosmetic grade, content ≥ 95%), the fatty acid was palmitic acid (Malaysia Italian brand, cosmetic grade, content ≥ 99%), the antioxidant was tocopherol acetate (German Basff brand, cosmetic grade, content ≥ 98%), and the emulsifier was MONTANOV containing coco glucosideTMS (France Saibek brand, cosmetic Grade, content is more than or equal to 99%), the pH value regulator is lactic acid (Henan Jindan brand, cosmetic Grade, content is more than or equal to 80%), the squalene is Shaanxi Jia and biological brand (cosmetic Grade, content is more than or equal to 80%), and the cholesterol is American Mecline brand (Sigma Grade, content is more than or equal to 99%).
TABLE 1 simulated skin lipid surface layer component ratios (unit: parts by weight)
3 Experimental procedures
The cosmetics used for the test were sample 374 (elegant peel essence) and sample 591 (elegant whitening emulsion), and the sensory evaluation indexes of the test were ease of application, whiteness, coverage, skin brightness, and skin tack.
The tests were divided into two groups: in the first group, 7 specially trained evaluators perform sensory evaluation on the cosmetics on the skin measured in the arms of the evaluators, and the evaluators are used for verification and recording the verification value of the evaluators; the second group was conducted by applying cosmetics to the surfaces of simulated skin samples 1 to 9 by an evaluator for sensory evaluation, using instrument verification, and recording the instrument verification score.
The evaluation method, the scoring standard, and the instrument verification method for each index of sensory evaluation are shown in table 2.
TABLE 2 evaluation method, evaluation standard and instrument verification method for sensory evaluation index
4 results of the experiment
The results of the sensory evaluations of this experiment on sample 374 and sample 591 are shown in tables 3 and 4.
TABLE 3 sensory evaluation results of sample 374
| Sensory evaluation index | Ease of application | Whiteness enhancement | Degree of coverage | Skin radiance | Degree of skin sticking to hands |
| Evaluator 1 | 12.2 | 3.9 | 2.5 | 7.6 | 8.4 |
| Evaluator 2 | 12.5 | 3.9 | 2.5 | 7.3 | 7.8 |
| Evaluator 3 | 12.5 | 3.8 | 2.3 | 7.2 | 8.0 |
| Evaluator 4 | 12.4 | 3.2 | 2.8 | 7.6 | 7.8 |
| Evaluator 5 | 12.7 | 3.7 | 2.3 | 7.3 | 7.5 |
| Evaluator 6 | 12.5 | 3.5 | 2.1 | 7.5 | 8.5 |
| Evaluator 7 | 12.6 | 3.7 | 2.8 | 7.7 | 8.0 |
| Average value Xi of 7 evaluators | 12.5 | 3.7 | 2.5 | 7.5 | 8.0 |
| Sample No. 1 | 11.9 | 3.1 | 1.8 | 6.7 | 7.5 |
| Sample No. 2 | 12.1 | 3.4 | 2.1 | 6.6 | 7.5 |
| Sample No. 3 | 12.2 | 3.2 | 2.4 | 6.9 | 7.4 |
| Sample No. 4 | 12.1 | 3.1 | 2.1 | 7.3 | 7.6 |
| Sample No. 5 | 12.4 | 3.7 | 2.3 | 7.2 | 8.0 |
| Sample No. 6 | 12.4 | 3.6 | 2.4 | 7.6 | 8.2 |
| Sample 7 | 12.7 | 3.9 | 2.8 | 7.9 | 8.2 |
| Sample 8 | 13.2 | 4.4 | 3.3 | 8.1 | 8.6 |
| Sample 9 | 13.1 | 4.5 | 3.2 | 8.3 | 8.5 |
TABLE 4 sensory evaluation results of sample 591
| Sensory evaluation index | Ease of application | Whiteness enhancement | Degree of coverage | Skin radiance | Degree of skin sticking to hands |
| Evaluator 1 | 10.0 | 9.7 | 7.3 | 7.6 | 7.3 |
| Evaluator 2 | 10.3 | 9.2 | 6.2 | 7.8 | 8.4 |
| Evaluator 3 | 10.5 | 9.3 | 6.2 | 8.7 | 8.6 |
| Evaluator 4 | 10.1 | 9.7 | 7.3 | 8.4 | 8.1 |
| Evaluator 5 | 10.5 | 9.2 | 6.6 | 7.5 | 8.5 |
| Evaluator 6 | 10.6 | 9.5 | 7.5 | 8.5 | 7.8 |
| Evaluator 7 | 10.2 | 9.0 | 6.6 | 7.4 | 7.4 |
| Average value Xi of 7 evaluators | 10.3 | 9.4 | 6.8 | 8.0 | 8.0 |
| Sample No. 1 | 9.2 | 9.0 | 6.2 | 7.8 | 7.3 |
| Sample No. 2 | 9.5 | 9.4 | 7.6 | 8.0 | 7.5 |
| Sample No. 3 | 9.8 | 9.5 | 6.1 | 8.0 | 7.4 |
| Sample No. 4 | 9.8 | 9.5 | 7.5 | 7.8 | 7.2 |
| Sample No. 5 | 10.2 | 9.8 | 6.4 | 8.1 | 7.9 |
| Sample No. 6 | 10.1 | 9.7 | 6.7 | 7.6 | 8.3 |
| Sample 7 | 10.4 | 9.4 | 6.8 | 8.4 | 8.2 |
| Sample 8 | 10.9 | 10.3 | 7.7 | 8.9 | 8.8 |
| Sample 9 | 11.1 | 10.2 | 7.5 | 8.9 | 8.7 |
5 analysis of results
And taking an average value Xi from the sensory evaluation test data of the real human skin of 7 evaluators, and defining the range of plus or minus 1 of the average value Xi as the sensory evaluation test result which accords with the sensory evaluation effect of the real human skin. Wherein i represents the degree of easiness in smearing, whiteness increasing, coverage, skin brightness or skin hand-sticking degree.
From the sensory evaluation test results in tables 3 and 4, the lipid surface layer composition of the skin-imitated material of the present invention has sensory evaluation test data falling within the range of [ Xi ± 1] in the ranges of 5 to 100 parts of triglyceride, 1.5 to 40 parts of squalene, 0.6 to 20 parts of fatty acid, 5 to 200 parts of emulsifier, 2.5 to 50 parts of wax ester, 0.2 to 20 parts of cholesterol, 0.1 to 5 parts of antioxidant, 100 to 1000 parts of water, and pH adjuster for adjusting the pH value of the skin-imitated material to 4.5 to 6.5. The results of the simulated skin samples 1 to 9 of the embodiment, which are tested by various skin test instruments, are close to the results of the real human skin in 5 sensory evaluation indexes of the smearing difficulty, the whiteness, the coverage, the skin brightness and the skin hand-sticking degree. The simulated skin samples 1 to 9 of the present embodiment can be applied to cosmetic sensory tests and can be used as substitutes for human skin.
Wherein, the preferable proportioning range of the lipid surface layer is as follows: 40-60 parts of oil triester, 10-20 parts of squalene, 4.8-10 parts of fatty acid, 40-60 parts of emulsifier, 20-30 parts of wax ester, 1.6-5 parts of cholesterol, 1-5 parts of antioxidant and 500-1000 parts of water. The test results of samples 5 to 7 for preparing the lipid surface layer in the preferred proportioning range are closest to the average value Xi of the real human skin sensory evaluation test of each sensory evaluation index.
The simulated skin provided by the invention is used as a cosmetic sensory evaluation tool, and can test sensory evaluation indexes such as whiteness, coverage, skin brightness, skin stickiness and the like of the cosmetic after being applied to human skin. The simulation skin sensory evaluation test effect is close to the test effect of real human skin, the fatigue caused by long-time sensory test on human skin and the safety problem that cosmetics bring sensitization risk to human skin are avoided, the simulation skin sensory evaluation test effect can be used as a substitute of a sensory test object, the simulation skin sensory evaluation test effect is suitable for being popularized in the field of cosmetic sensory evaluation, the promotion of the development of cosmetic sensory evaluation technology is facilitated, and the simulation skin sensory evaluation test effect has a wide market prospect.
Example 6.
The simulated skin of the present invention was compared with the base of the present invention having no fat applied to the surface for cosmetic sensory evaluation
Experiment of
Purpose of the experiment
The simulated skin and the substrate without oil and fat applied on the surface of the invention are used as cosmetic sensory evaluation tools, and the differences of the sensory evaluation indexes such as coating difficulty, whiteness, coverage, skin brightness, skin stickiness and the like are compared.
2 preparation of the experiment
Simulated skin samples 1 to 6 were prepared as in example 5.
Comparative examples 1, 2 and 3 were prepared by the processes of step 1 to step 5 of example 4. Comparative examples 1, 2 and 3 are substrates that were not treated with a grease. The surface friction coefficient of comparative example 1 was 0.43, the surface friction coefficient of comparative example 2 was 0.52, and the surface friction coefficient of comparative example 3 was 0.59.
3 Experimental procedures
The cosmetics used for the test were sample 374 and sample 591, and the sensory evaluation indices of the test were ease of application, whiteness, coverage, skin brightness, and skin tack.
The cosmetic was applied to the surfaces of comparative examples 1 to 3 by an evaluator for sensory evaluation, and the instrumental authentication score was recorded.
Evaluation methods, scoring criteria, and instrument verification methods for sensory evaluation of the respective indices are shown in table 2 of example 5.
4 results of the experiment
The results of the sensory evaluations of this experiment on sample 374 and sample 591 are shown in tables 5 and 6.
Table 5 sensory evaluation test data of sample 374 on simulated skin and general polyurethane artificial leather
| Sensory evaluation index | Ease of application | Whiteness enhancement | Degree of coverage | Skin radiance | Degree of skin sticking to hands |
| Comparative example 1 | 11.1 | 1.9 | 1.2 | 10.5 | 11.0 |
| Comparative example 2 | 11.4 | 1.8 | 1.0 | 10.8 | 11.6 |
| Comparative example 3 | 13.8 | 2.5 | 3.7 | 10.0 | 11.4 |
| Average value Xi of 7 evaluators | 12.5 | 3.7 | 2.5 | 7.5 | 8.0 |
Table 6 sensory evaluation test data of sample 591 on simulated skin and general polyurethane artificial leather
| Sensory evaluation index | Ease of application | Whiteness enhancement | Degree of coverage | Skin radiance | Degree of skin sticking to hands |
| Comparative example 1 | 12.2 | 6.0 | 5.1 | 12.0 | 10.1 |
| Comparative example 2 | 12.5 | 6.5 | 5.0 | 11.6 | 10.5 |
| Comparative example 3 | 11.7 | 7.1 | 5.2 | 11.5 | 10.0 |
| Average value Xi of 7 evaluators | 10.3 | 9.4 | 6.8 | 8.0 | 8.0 |
5 analysis of results
And taking an average value Xi from the sensory evaluation test data of the real human skin of 7 evaluators, and defining the range of plus or minus 1 of the average value Xi as the sensory evaluation test result which accords with the sensory evaluation effect of the real human skin. Wherein i represents the degree of easiness in smearing, whiteness increasing, coverage, skin brightness or skin hand-sticking degree. The reference standard of this example is the average value Xi of the sensory evaluation test of real human skin of 7 evaluators of example 5.
The results show that in comparative examples 1 to 3 of the present example, the matrix without being coated with the oil and fat had a surface friction coefficient in accordance with the friction coefficient range of the real human skin, and the friction coefficient was between 0.4 and 0.6, but the sensory evaluation test data of the matrix deviated from the range of [ Xi ± 1], i.e., the matrix did not conform to the sensory evaluation effect of the real human skin. As is clear from example 5, the cosmetic sensory evaluation test data of the simulated skin according to the present invention is close to the data of the real human skin, and thus it was confirmed that the substrate which was not subjected to the treatment of applying oil or fat did not satisfy the conditions as a cosmetic sensory evaluation test tool and could not be used as a substitute for human skin.
Example 7.
Experiment of influence of lipid composition of simulated skin on sensory evaluation of cosmetic
Purpose of the experiment
The lipid surface layer composition of the invention is subjected to element reduction experiments, and the importance of each composition component in the lipid surface layer of the invention on simulating the real human skin effect is verified.
2 preparation of the experiment
Simulated skin sample 10 and comparative examples 4 to 14 were prepared as in example 4, wherein the lipid top layer composition of each simulated skin was prepared in the proportions shown in table 7. The experiment was based on the lipid surface layer of the simulated skin sample 10 of the present invention as a reference.
TABLE 7 proportioning of lipid (unit: parts by weight) for skin surface lipid simulation in simulated skin
3 Experimental procedures
The cosmetics used for the test were sample 374 and sample 591, and the sensory evaluation indices of the test were ease of application, whiteness, coverage, skin brightness, and skin tack.
The test is divided into three groups: the first group is that the evaluator trained professionally evaluates the cosmetics on the skin measured in the arm, uses the instrument for verification, and records the verification value of the instrument; in the second group, the evaluator applies the cosmetics on the surface of the simulated skin sample 10 for sensory evaluation, and the instrument is used for verification and recording the verification value of the instrument; the third group was conducted by applying cosmetics to the surfaces of comparative simulated skin examples 4 to 14 by an evaluator for sensory evaluation, using instrumental verification, and recording instrumental verification scores.
Evaluation methods, scoring criteria, and instrument verification methods for sensory evaluation of the respective indices are shown in table 2 of example 5.
4 results of the experiment
The results of the sensory evaluations of this experiment on sample 374 and sample 591 are shown in tables 8 and 9.
Table 8 sample 374 sensory evaluation test data
TABLE 9 sample 591 sensory evaluation test data
5 analysis of results
And taking the real human skin sensory evaluation test data as a reference value Zj. And defining the range of the Zj value plus or minus 1 as that the sensory evaluation test result accords with the sensory evaluation effect of the real human skin. Wherein j represents the degree of easiness in smearing, whiteness increasing, coverage, skin brightness or skin hand-sticking degree.
As is clear from the results of tables 8 and 9, the sensory evaluation test data of the simulated skin sample 10 of the present invention all fall within [ Zj. + -. 1 [)]The range of (1) is in accordance with the sensory evaluation effect of the skin of a real human body. In each of the sensory evaluation test data of comparative examples 4 to 14, there were cases where 2 to 5 sensory evaluation indexes failed to meet the standards. Wherein the lipid surface layer composition is deficient in caprylic/capric triglyceride, squalene, palmitic acid and MONTANOV, respectivelyTMThe 5 sensory evaluation indexes of the S emulsifier comparative examples 11 to 14 all reach the standard, and deviate from the test data of real human skin to a large extent. Demonstration of caprylic/capric triglyceride (triglyceride), squalene, palmitic acid (fatty acid) and MONTANOVTMThe S emulsifier is an important component for simulating the structure of the human body skin lipid membrane.
The lipid top layer compositions of comparative examples 4 to 10 were designed with several additions of jojoba oil (wax ester), cholesterol, tocopherol acetate (antioxidant). The sensory evaluation test data of comparative examples 4 to 10 did not completely meet the standards, and the degree of deviation from the test data of real human skin was not as severe as that of comparative examples 11 to 14 lacking important components in the non-met index data. Further illustrated are caprylic/capric triglyceride (triglyceride), squalene, palmitic acid (fatty acid) and MONTANOVTMS emulsifiers are essential materials for preparing simulated skin that can be used for cosmetic sensory evaluation.
In conclusion, the simulated skin provided by the invention can be used as a cosmetic sensory evaluation tool to test sensory evaluation indexes such as the coating difficulty, the whiteness, the coverage degree, the skin brightness, the skin stickiness and the like of the cosmetics after being applied to human skin. The simulation skin sensory evaluation test effect is close to the test effect of real human skin, the fatigue caused by long-time sensory test on human skin and the safety problem that cosmetics bring sensitization risk to human skin are avoided, the simulation skin sensory evaluation test effect can be used as a substitute of a sensory test object, the simulation skin sensory evaluation test effect is suitable for being popularized in the field of cosmetic sensory evaluation, the promotion of the development of cosmetic sensory evaluation technology is facilitated, and the simulation skin sensory evaluation test effect has a wide market prospect.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The simulated skin for sensory evaluation is characterized by being provided with a matrix and a lipid surface layer coated on the surface of the matrix.
2. The simulated skin for sensory evaluation according to claim 1, wherein said base comprises a base layer and an elastic layer coated and solidified on a surface of said base layer, and a lipid surface layer is positioned on a surface of said elastic layer.
3. The simulated skin for sensory evaluation according to claim 2, wherein said lipid top layer comprises, in parts by weight: 5-100 parts of triglyceride, 1.5-40 parts of squalene, 0.6-20 parts of fatty acid and 5-200 parts of emulsifier.
4. The simulated skin for sensory evaluation according to claim 3, wherein said lipid top layer further comprises, in parts by weight: 2.5-50 parts of wax ester, 0.2-20 parts of cholesterol, 0.1-5 parts of antioxidant, 100-1000 parts of water and pH value regulator for regulating the pH value range of the simulated skin to 4.5-6.5.
5. The simulated skin for sensory evaluation according to claim 4, wherein said lipid top layer comprises, in parts by weight: 40-60 parts of triglyceride, 10-20 parts of squalene, 4.8-10 parts of fatty acid, 40-60 parts of emulsifier, 20-30 parts of wax ester, 1.6-5 parts of cholesterol, 1-5 parts of antioxidant and 500-1000 parts of water.
6. Simulated skin for sensory evaluation according to claim 3 or 4,
the triglyceride is at least one of caprylic/capric triglyceride, and triolein;
the wax ester is at least one of jojoba oil, palm wax, candelilla wax and beeswax;
the fatty acid is at least one of palmitic acid, lauric acid and myristic acid;
the antioxidant is at least one of tocopherol acetate, di-tert-butyl-p-cresol and tert-butyl hydroxyanisole;
the emulsifier is at least one of coco glucoside, cetearyl glucoside and arachidyl glucoside;
the pH value regulator is lactic acid.
7. The simulated skin for sensory evaluation according to any one of claims 1 to 4, wherein the surface friction coefficient is in the range of 0.4 to 0.6, and the pH value is in the range of 4.5 to 6.5;
the basic unit is water thorn non-woven fabrics, the elastic layer is the polyurethane resin layer.
8. A method of preparing simulated skin for sensory evaluation according to any one of claims 1 to 7, comprising the step of applying oil or fat to the surface of the base.
9. The method for preparing simulated skin for sensory evaluation according to claim 8, comprising the steps of:
step one, preparing a substrate;
secondly, coloring the matrix by simulating the skin color of the human body;
thirdly, carrying out human pore texture imitation embossing on the colored matrix;
washing and drying the colored and embossed matrix to obtain a matrix simulating skin complexion and pore texture of a human body;
step five, detecting whether the friction coefficient of the surface of the base body prepared in the step four is in a target friction coefficient range, and entering the step six when the detected friction coefficient is in the target friction coefficient range; if not, changing the depth of the texture imitating human body pores on the embossing roller to re-emboss the matrix until the friction coefficient of the surface of the matrix meets the range of the target friction coefficient, and entering the sixth step;
and step six, coating a lipid surface layer on the surface of the elastic layer of the substrate with the friction coefficient meeting the requirement of the target friction coefficient range to obtain the finished product of the simulated skin.
10. The method for preparing simulated skin for sensory evaluation according to claim 9, wherein in the first step, the step of preparing the base body comprises:
uniformly coating the pre-prepared polyurethane resin slurry on a base layer, and rolling the slurry by using an extrusion roller;
uniformly solidifying the slurry on the base layer through a water solidification tank to obtain unmodified polyurethane artificial leather;
in the fifth step, the range of the target friction coefficient is 0.4-0.6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110998539.0A CN113740491A (en) | 2021-08-27 | 2021-08-27 | Simulated skin for sensory evaluation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110998539.0A CN113740491A (en) | 2021-08-27 | 2021-08-27 | Simulated skin for sensory evaluation and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113740491A true CN113740491A (en) | 2021-12-03 |
Family
ID=78733554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110998539.0A Pending CN113740491A (en) | 2021-08-27 | 2021-08-27 | Simulated skin for sensory evaluation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113740491A (en) |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0813222A (en) * | 1994-07-01 | 1996-01-16 | Subuenson:Kk | Artificial skin or net as wig base |
| CN1795922A (en) * | 2000-03-27 | 2006-07-05 | 株式会社资生堂 | Agent promoting the formation of skin basement membrane, agents promoting the formation of artificial skin and process for producing artificial skin |
| CN101610902A (en) * | 2007-01-08 | 2009-12-23 | 宝洁公司 | Matrix with properties of mammalian skin |
| CN102781484A (en) * | 2010-03-04 | 2012-11-14 | 株式会社资生堂 | Artificial skin |
| CN103085402A (en) * | 2013-02-04 | 2013-05-08 | 苏春 | High-stimulation fur fabric and its making method |
| CN103948960A (en) * | 2014-05-20 | 2014-07-30 | 四川大学 | Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof |
| CN104499301A (en) * | 2014-11-17 | 2015-04-08 | 杭州苏威进出囗有限公司 | Preparation technology for synthesizing leather by durable environmental protection wet-type PU |
| CN104548214A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Artificial skin and preparation method thereof |
| CN106668937A (en) * | 2016-12-16 | 2017-05-17 | 深圳市茵冠生物科技有限公司 | Bionic skin and preparation method thereof |
| CN108567997A (en) * | 2018-06-04 | 2018-09-25 | 上海其鸿新材料科技有限公司 | A kind of high strength elastic stealth artificial skin |
| TW201843235A (en) * | 2017-05-08 | 2018-12-16 | 新賀工業股份有限公司 | Synthetic leather of expanded thermoplastic polyurethane (e-TPU), fabrication method therefor and formula preventing the mixture of TPU from being sticking under a melting status |
| CN110997025A (en) * | 2017-07-31 | 2020-04-10 | 美珂斯株式会社 | Composition for preparing artificial skin comprising fibrous polymer and method for preparing artificial skin using the same |
| CN111341188A (en) * | 2020-04-27 | 2020-06-26 | 上海临韵智达智能科技有限公司 | Human body simulation skin and manufacturing method thereof |
| CN111700713A (en) * | 2020-06-24 | 2020-09-25 | 福建华民生物科技有限公司 | Artificial skin |
| CN112870438A (en) * | 2021-02-04 | 2021-06-01 | 合肥科天水性科技有限责任公司 | Application of bio-based waterborne polyurethane in artificial skin surface material |
| US20210209967A1 (en) * | 2018-08-30 | 2021-07-08 | Universite Le Havre Normandie | Non-biological skin model |
-
2021
- 2021-08-27 CN CN202110998539.0A patent/CN113740491A/en active Pending
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0813222A (en) * | 1994-07-01 | 1996-01-16 | Subuenson:Kk | Artificial skin or net as wig base |
| CN1795922A (en) * | 2000-03-27 | 2006-07-05 | 株式会社资生堂 | Agent promoting the formation of skin basement membrane, agents promoting the formation of artificial skin and process for producing artificial skin |
| CN101610902A (en) * | 2007-01-08 | 2009-12-23 | 宝洁公司 | Matrix with properties of mammalian skin |
| CN102781484A (en) * | 2010-03-04 | 2012-11-14 | 株式会社资生堂 | Artificial skin |
| CN103085402A (en) * | 2013-02-04 | 2013-05-08 | 苏春 | High-stimulation fur fabric and its making method |
| CN103948960A (en) * | 2014-05-20 | 2014-07-30 | 四川大学 | Nano-silver porous silicone rubber/polyurethane-containing double-layer artificial skin and preparation method thereof |
| CN104499301A (en) * | 2014-11-17 | 2015-04-08 | 杭州苏威进出囗有限公司 | Preparation technology for synthesizing leather by durable environmental protection wet-type PU |
| CN104548214A (en) * | 2015-02-10 | 2015-04-29 | 广州赛莱拉干细胞科技股份有限公司 | Artificial skin and preparation method thereof |
| CN106668937A (en) * | 2016-12-16 | 2017-05-17 | 深圳市茵冠生物科技有限公司 | Bionic skin and preparation method thereof |
| TW201843235A (en) * | 2017-05-08 | 2018-12-16 | 新賀工業股份有限公司 | Synthetic leather of expanded thermoplastic polyurethane (e-TPU), fabrication method therefor and formula preventing the mixture of TPU from being sticking under a melting status |
| CN110997025A (en) * | 2017-07-31 | 2020-04-10 | 美珂斯株式会社 | Composition for preparing artificial skin comprising fibrous polymer and method for preparing artificial skin using the same |
| CN108567997A (en) * | 2018-06-04 | 2018-09-25 | 上海其鸿新材料科技有限公司 | A kind of high strength elastic stealth artificial skin |
| US20210209967A1 (en) * | 2018-08-30 | 2021-07-08 | Universite Le Havre Normandie | Non-biological skin model |
| CN111341188A (en) * | 2020-04-27 | 2020-06-26 | 上海临韵智达智能科技有限公司 | Human body simulation skin and manufacturing method thereof |
| CN111700713A (en) * | 2020-06-24 | 2020-09-25 | 福建华民生物科技有限公司 | Artificial skin |
| CN112870438A (en) * | 2021-02-04 | 2021-06-01 | 合肥科天水性科技有限责任公司 | Application of bio-based waterborne polyurethane in artificial skin surface material |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2011155765A2 (en) | Method for preparing customized cosmetics | |
| CN109288757B (en) | Lipstick with repairing effect and preparation method thereof | |
| Gelineau | A psychometric approach to the measurement of color preference | |
| CN102406578B (en) | Silky bright-color smoothing toner composition | |
| Sohm et al. | Evaluation of the efficacy of a dill extract in vitro and in vivo | |
| CN112494400A (en) | Organic pressed powder and preparation method thereof | |
| CN110025506B (en) | Frosted color-changing lip balm and preparation method thereof | |
| CN111714414A (en) | Velvet matte lip glaze and preparation method thereof | |
| CN106061458B (en) | Concealer patch, manufacturing method thereof, skin whitening and protecting method and anti-acne and protecting method | |
| CN113740491A (en) | Simulated skin for sensory evaluation and preparation method thereof | |
| WO2014170807A1 (en) | Device for evaluating a product on application | |
| CN114432182A (en) | Make-up fixing spray with oil control effect and preparation method thereof | |
| CN104146931B (en) | A kind of natural nourishing maintenance type hair conditioner and preparation method thereof | |
| JPH11169390A (en) | Artificial skin | |
| CN108685739A (en) | It is a kind of repair skin barrier reduce acne skin matrix and its prepare with its cosmetics | |
| CN105496874B (en) | A kind of whitening and moisturizing face cream containing plant extracts and preparation method thereof | |
| CN112641672A (en) | Water-based lasting lip gloss | |
| CN108042455A (en) | A kind of whitening and moisturizing profit body frost and preparation method thereof | |
| CN105411949B (en) | A kind of whitening and moisturizing hand lotion containing plant extracts and preparation method thereof | |
| CN102631308B (en) | Skin care composition and preparation with effects of improving skin textures and increasing skin elasticity and preparation methods thereof | |
| CN103211743B (en) | Preparation method of smoothing toner composition containing natural plant extract | |
| CN105963156B (en) | Pregnant line massage lotion and preparation method thereof | |
| CN108261379A (en) | A kind of facial mask and preparation method thereof | |
| CN104070915B (en) | Bionic natural-efficacy plant essential oil painting with fragrance and preparing method of painting | |
| CN113057904A (en) | Moisture-retaining pressed powder containing fibroin and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |