CN105963156B - Pregnant line massage lotion and preparation method thereof - Google Patents
Pregnant line massage lotion and preparation method thereof Download PDFInfo
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- CN105963156B CN105963156B CN201610485100.7A CN201610485100A CN105963156B CN 105963156 B CN105963156 B CN 105963156B CN 201610485100 A CN201610485100 A CN 201610485100A CN 105963156 B CN105963156 B CN 105963156B
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- Cosmetics (AREA)
Abstract
The invention discloses a kind of pregnant line massage lotion, which includes the first component, the second component, third component and the 4th component；Wherein, first component includes water, EDETATE SODIUM and moisturizer；Second component includes PEG-60 Span60 and emollients；Third component includes water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer；4th component includes Argireline, -30 citrulling of acetyl group tripeptides and pentapeptide, has the effect of reducing product quality otherness.
Description
Technical Field
The invention relates to the field of skin care, and particularly relates to a pregnancy line massage lotion and a preparation method thereof.
Background
A pregnancy line, refers to a strip or band of skin that appears after skin hyper-swelling and hormonal changes. The women are affected by hormone during pregnancy, the abdominal bulge causes the elastic fibers and the collagen fibers of the skin to be damaged or broken in different degrees due to external force traction, the skin becomes thinner and thinner, the skin of the abdominal wall becomes thinner and thinner, and the skin of the abdominal wall can have pink or purple wave-shaped patterns with different widths and lengths; after delivery, these patterns gradually disappear, leaving white or silvery-white scars as light marks. The pregnant wrinkles are not easy to disappear, and the skin of the woman is loose, wrinkled, fat accumulated on the abdomen, breast drop and the like, so that the physical state and the physical and mental health of the woman after delivery are seriously influenced. At present, the industry commonly considers that the optimal treatment time of the pregnancy line is the pregnancy period when the pregnancy line just appears; there are also a number of products on the market that treat the pregnancy lines, where the use of essential oils to remove the pregnancy lines is a common way.
Chinese patent with application publication No. CN105534746A and application publication No. 2016, 5 and 4 discloses stretch mark repairing essential oil for massage, which is prepared from sweet almond oil, wheat germ oil, citronellal, methyl anthranilate, silk peptide, hyaluronic acid, amino acid, coconut collagen, orange essential oil, frankincense essential oil, orange flower essential oil, lavender essential oil, citrus essential oil, frankincense essential oil and avocado oil.
The defects of the prior art are that the aim of repairing the stretch marks is fulfilled by adopting a considerable amount of different essential oils, however, the essential oils have the characteristic of easy volatilization, and the volatilization degrees of the different essential oils are different, so that the quality of stored products is different, and the using effect is influenced.
Disclosure of Invention
The first purpose of the invention is to provide a pregnancy line massage cream, which solves the problem of inconsistent product quality caused by product volatilization and has the effect of reducing the quality difference of products.
The technical purpose of the invention is realized by the following technical scheme:
a massage lotion for treating pregnant streaks comprises a first component, a second component, a third component and a fourth component; wherein,
the first component comprises water, disodium EDTA and a humectant;
the second component comprises PEG-60 sorbitan stearate and a softening agent;
the third component comprises water and acrylic/C10-30 alkanol acrylate crosspolymer;
the fourth component comprises acetyl hexapeptide-8, acetyl tripeptide-30 citrulline and pentapeptide.
By adopting the technical scheme, the combined action of the acetyl hexapeptide-8, the acetyl tripeptide-30 citrulline and pentapeptide influences the vesicular complex, and reduces the speed and release amount of neurotransmitter released by the vesicle, thereby weakening the muscle contraction and reducing the generation of stretch marks and wrinkles; meanwhile, the skin-care product can supplement nutrition to the damaged skin, and can improve and reduce the existing striae gravidarum after being absorbed by the skin; meanwhile, the moisturizer and the emollient are utilized to fulfill the aims of locking water and replenishing water, so that the skin condition is further improved;
the volatile substance such as essential oil is not adopted in the technical scheme of this application, and each component volatilizees in the product and can be ignored, and the application further reduces the possibility that each component volatilizees through the interact between each component, makes the product quality of depositing stable, ensures the result of use.
Research shows that the dosage ratio of the first component to the second component to the third component to the fourth component is 18-22: 19-23: 10-13: 1;
in the first component, the dosage ratio of water, EDTA disodium and humectant is 1: 0.1% -0.2%: 0.25 to 0.35;
in the second component, the dosage ratio of PEG-60 sorbitan stearate to the softening agent is 3% -6%: 1;
in the third component, the dosage ratio of water to acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer is 1: 0.8% -2%;
in the fourth component, the dosage ratio of acetyl hexapeptide-8, acetyl tripeptide-30 citrulline and pentapeptide is 1: 0.5-1.5: 0.5-1.5, and the process and the product quality can obtain the optimal balance point.
More preferably: the humectant comprises 3 to 5 weight percent of triethanolamine, 2 to 3 weight percent of hyaluronic acid, 55 to 60 weight percent of glycerol and 32 to 40 weight percent of dipropylene glycol.
By adopting the technical scheme, the triethanolamine, the hyaluronic acid, the glycerol and the dipropylene glycol are combined to lock water and replenish water from multiple layers of skin, and the skin is clear and transparent, so that the skin-care liquid is suitable for pregnant women with relatively high body temperature.
More preferably: the emollient comprises 1-2 wt% of stearic acid, 2-4 wt% of glyceryl stearate, 2-4 wt% of polydimethylsiloxane, 50-60 wt% of dioctyl carbonate, 20-25 wt% of caprylic/capric triglyceride, 2-4 wt% of crab apple seed oil, 5-10 wt% of isononyl isononanoate and 8-15 wt% of cetyl ethyl hexanoate.
By adopting the technical scheme, stearic acid, glyceryl stearate, polydimethylsiloxane, dioctyl carbonate, caprylic/capric triglyceride, crab apple seed oil, isononyl isononanoate and cetyl ethyl hexanoate are combined to act, so that the viscosity and yield point are reduced, the fluidity and surface tension of an emulsion system are improved, the emulsion is easy to disperse and prepare, and the emulsion which is uniformly dispersed and stable is obtained; after the combination action of the softening agents, the spreading performance is good when the softening agents are applied, and the absorption of the pregnant-line massage lotion is easily promoted, so that the skin is smooth, soft, elastic and clear.
More preferably: the fourth component also comprises a preservative and essence; according to the mass ratio of the acetyl hexapeptide-8 to the preservative to the essence is 1: 0.2-0.5: 0.1 to 0.2.
By adopting the technical scheme, the service life of the product is prolonged, the fragrance of the product is adjusted, and the applicability of the product is improved.
More preferably: the hyaluronic acid comprises Mr of (1-2) x 106HAs a value of (1-8). times.10 for HA and Mr4The HA of (1).
By adopting the technical scheme, the micromolecular hyaluronic acid enters the skin to replenish water to the inner layer, and the macromolecule hyaluronic acid is positioned outside and inside the skin to lock water and absorb water on the surface of the skin, so that the water content of the skin is improved.
The second purpose of the invention is to provide a preparation method of the pregnancy line massage cream.
The technical purpose of the invention is realized by the following technical scheme:
the preparation method of the pregnant streaky massage lotion comprises the following steps:
step 1: mixing the raw materials of the first component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed first component;
step 2: mixing the raw materials of the second component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed second component;
and step 3: mixing the raw materials of the third component according to the formula amount, and stirring to obtain a uniformly dispersed third component;
and 4, step 4: mixing the raw materials of the fourth component according to the formula amount, and stirring to obtain a uniformly dispersed fourth component;
and 5: under the heat preservation state, adding the second component obtained by the treatment in the step 2 into the first component obtained in the step 1, homogenizing and uniformly dispersing; then, under the heat preservation state, adding the third component obtained by the treatment in the step 3, homogenizing and uniformly dispersing; cooling the material body to 42-45 ℃, adding the fourth component obtained by the treatment in the step 4, homogenizing and uniformly dispersing; and cooling to 25-30 ℃ to obtain the product.
By adopting the technical scheme, the process is easy to disperse, the activity of each raw material is kept, and the obtained product has good dispersibility and is easy to develop.
Research shows that the dosage ratio of the first component to the second component to the third component to the fourth component is 18-22: 19-23: 10-13: 1;
the first component comprises water, disodium EDTA and a humectant; in the first component, the dosage ratio of water, EDTA disodium and humectant is 1: 0.1% -0.2%: 0.25 to 0.35; the humectant comprises 3 to 5 weight percent of triethanolamine, 2 to 3 weight percent of hyaluronic acid, 55 to 60 weight percent of glycerol and 32 to 40 weight percent of dipropylene glycol; the hyaluronic acid comprises Mr of (1-2) x 106HAs a value of (1-8). times.10 for HA and Mr4The HA of (a);
the second component comprises PEG-60 sorbitan stearate and a softening agent; in the second component, the dosage ratio of PEG-60 sorbitan stearate to the softening agent is 3% -6%: 1; the emollient comprises 1-2 wt% of stearic acid, 2-4 wt% of glyceryl stearate, 2-4 wt% of polydimethylsiloxane, 50-60 wt% of dioctyl carbonate, 20-25 wt% of caprylic/capric triglyceride, 2-4 wt% of crab apple seed oil, 5-10 wt% of isononyl isononanoate and 8-15 wt% of cetyl ethyl hexanoate;
the third component comprises water and acrylic acid/C10-30 alkanol acrylate cross-linked polymer, and the dosage ratio of the water and the acrylic acid/C10-30 alkanol acrylate cross-linked polymer in the third component is 1: 0.8% -2%;
the fourth component comprises acetyl hexapeptide-8, acetyl tripeptide-30 citrulline, pentapeptide, preservative and essence, and in the fourth component, the dosage ratio of the acetyl hexapeptide-8, the acetyl tripeptide-30 citrulline, the pentapeptide, the preservative and the essence is 1: 0.5-1.5: 0.5-1.5: 0.2-0.5: 0.1-0.2, and the process and the product quality can obtain the optimal balance point.
More preferably: the crabapple seed oil is prepared by the following method:
taking crabapple seeds, adding an ethanol water solution, performing heat preservation and ultrasonic extraction for 0.5-2 hr at the temperature of 5-30 ℃, extracting for 2-3 times, combining extract liquor, filtering, and performing heat preservation and concentration at the temperature of 5-30 ℃ to obtain an alcohol extract; and adding water into the concentrated alcohol extract, extracting, and volatilizing the solvent at 5-30 ℃ to obtain the alcohol extract.
By adopting the technical scheme, the biological activity of the crab apple seeds can be maintained by low-temperature operation, and meanwhile, the crab apple seed oil prepared by the method has high yield and better skin moistening effect; the crab apple seed oil volatilizing the solvent is adopted, has no stimulation and is suitable for pregnant women.
More preferably: the Chinese flowering crabapple fruit seed raw material is subjected to drying and crushing pretreatment, wherein the drying is freeze drying at the temperature of-20-0 ℃, and the crushing is heat preservation crushing at the temperature of 5-30 ℃; the ethanol aqueous solution consists of 75-90 wt% of ethanol and 10-25 wt% of water, the weight ratio of the dry weight of the Chinese flowering crabapple seeds to the amount of the ethanol aqueous solution used for extraction is 1: 2-5, and the weight ratio of the concentrated ethanol extract to the water is 1: 2-5.
By adopting the technical scheme, the raw material is treated by freeze drying, so that the raw material loses water instantly and is kept in the original shape basically, the raw material is easy to crush and can quickly act with an extraction solvent to accelerate the dissolution of active ingredients in the raw material.
In conclusion, the invention has the following beneficial effects:
1. the raw materials adopted by the application are non-irritant or low-irritant, do not generate irritant products after being mixed, are mild and non-irritant, and are suitable for pregnant women and lying-in women;
2. the pregnant line massage cream has the advantages that the speed for removing the pregnant lines is higher, the effect is better, and the pregnant line massage cream is suitable for pregnant women and lying-in women in the middle and later periods of pregnancy;
3. after the pregnant line massage lotion is used, the skin feeling is clearer, and the smearing and spreading performance is improved;
4. after the pregnant line massage cream is used, the skin is firmer, the condition of skin looseness can be improved, and the skin is shinier and more elastic.
Detailed Description
Unless otherwise noted, all materials used herein meet international cosmetic material standards, and thus the origin of individual components is not noted in this application. The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Examples 1 to 3: the crabapple seed oil is prepared by the following method:
pretreatment: taking a crab apple seed raw material, freeze-drying at-20-0 ℃ to constant weight, and carrying out heat preservation and crushing at 5-30 ℃ to 100-200 meshes;
extraction: taking pretreated Chinese flowering crabapple seeds, adding an ethanol water solution, extracting for 2-3 times by heat preservation and ultrasonic treatment at 5-30 ℃ for 0.5-2 hr, combining the extract, filtering, and concentrating at 5-30 ℃ to obtain an alcohol extract; adding water into the concentrated alcohol extract, extracting, and volatilizing the solvent at 5-30 ℃ to obtain the final product;
the raw material information of examples 1 to 3 is shown in Table 1.
TABLE 1 information on the raw materials in the crab apple seed oil of examples 1-3
Examples 4 to 6: the pregnant wrinkle massage lotion is prepared by the following method:
step 1: mixing the raw materials of the first component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed first component;
step 2: mixing the raw materials of the second component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed second component;
and step 3: mixing the raw materials of the third component according to the formula amount, and stirring to obtain a uniformly dispersed third component;
and 4, step 4: mixing the raw materials of the fourth component according to the formula amount, and stirring to obtain a uniformly dispersed fourth component;
and 5: under the heat preservation state, adding the second component obtained by the treatment in the step 2 into the first component obtained in the step 1, homogenizing and uniformly dispersing; then, under the heat preservation state, adding the third component obtained by the treatment in the step 3, homogenizing and uniformly dispersing; cooling the material body to 42-45 ℃, adding the fourth component obtained by the treatment in the step 4, homogenizing and uniformly dispersing; then cooling to 25-30 ℃ to obtain the product;
the raw material information of examples 4 to 6 is shown in Table 2.
TABLE 2 information of each raw material in pregnancy pattern massage milks of examples 4 to 6
Example 7: pregnant marbled massage lotion, different from example 5 in that its crabapple seed oil was provided by the french green family.
Example 8: the pregnant wrinkle massage cream is different from the pregnant wrinkle massage cream in example 5 in that glycerin is replaced by dipropylene glycol in the humectant of the first component.
Example 9: the pregnant wrinkle massage cream is different from the pregnant wrinkle massage cream in example 5 in that dipropylene glycol is replaced with glycerin in the humectant of the first component.
Example 10: the pregnant wrinkle massage lotion is different from the lotion of the embodiment 5 in that the humectant of the first component is not added with triethanolamine, Mr is (1-2) x 106HAs a value of (1-8). times.10 for HA and Mr4The HA of (1).
Example 11: the pregnant wrinkle massage cream is different from the pregnant wrinkle massage cream in example 5 in that stearic acid, glyceryl stearate and polydimethylsiloxane are not added in the emollient of the second component.
Example 12: the pregnant massage cream is different from the cream of example 5 in that isononyl isononanoate and cetyl ethyl hexanoate are not added to the emollient of the second component.
Example 13: the pregnant streaky massage cream is different from the pregnant streaky massage cream in example 5 in that the emollient of the second component does not contain caprylic/capric triglyceride and crab apple seed oil.
Example 14: the pregnant streaky massage cream is different from the pregnant streaky massage cream in the embodiment 5 in that all the raw materials are directly stirred and mixed at room temperature (25 ℃) for 2 hours to obtain the pregnant streaky massage cream.
Example 15: the stretch mark repairing essential oil for massage is prepared according to example 1 of CN105534746A, and is prepared by directly stirring and mixing 50g of sweet almond oil, 8g of wheat germ oil, 1g of citronellal, 1g of methyl benzoate, 1.5g of fibroin peptide, 0.5g of hyaluronic acid, 2g of lysine, 2g of coconut collagen, 9g of orange essential oil, 2g of frankincense essential oil, 2g of orange flower essential oil, 2g of lavender essential oil, 13g of citrus essential oil, 5g of frankincense essential oil and 1g of avocado oil at room temperature (25 ℃) and uniformly dispersing the mixture.
Example 16: evaluation of use
Test subjects: examples 4 to 14 were used as test samples, and example 15 was used as a control.
Test contents A: randomly selecting 120 pregnant women with pregnancy period of 3-6 months and slight striae gravidarum (pink), and randomly dividing into 12 groups of 10 persons, wherein each group uses one test object; the use frequency is 3 times per day; the striae gravidarum removal effect was evaluated according to table 3 after 1 week and 1 month of use, while the smearing experience was evaluated according to tables 4 and 5;
test contents B: randomly selecting 120 pregnant women with gestational period of 6-10 months and obvious striae gravidarum (purple red or black), randomly dividing into 12 groups of 10 persons each, and using one test object each; the use frequency is 3 times per day; the striae gravidarum removing effect was evaluated according to table 3 after 1 week and 1 month of use, respectively;
test content C: randomly selecting 120 lying-in women with obvious striae gravidarum (black) within 1 month, randomly dividing into 12 groups of 10 persons, and using one test object in each group; the use frequency is 3 times per day; the striae gravidarum removing effect was evaluated according to table 3 after 1 week and 1 month of use, respectively;
and (3) test results: striae gravidarum removal effects are shown in tables 6, 8 and 9, and smearing experience evaluations are shown in table 7.
Tables 6, 8 and 9 show: compared with the control sample, the pregnancy mark massage cream of the examples 4-14 has faster speed and better effect of removing the pregnancy marks, and especially the pregnancy marks can be lightened and the range is reduced by more than 50% after the massage cream of the examples 4-6 is used for one month; the striae gravidarum removing massage lotion of examples 4 to 14 is suitable for pregnant women and parturients in and after the gestation period.
Table 7 shows: compared with the control, the skin feel is clearer after the massage cream of the examples 4 to 14 is applied, and the spreading property is general or easy to spread, particularly the spreading property and the skin feel are clearer after the massage cream of the examples 4 to 6 is used.
Meanwhile, researches show that the skin is firmer after the skin is used in the examples 4-14, the loose condition of the skin can be improved, and the skin is shinier and more elastic; and the skin improvement effect was the best after using examples 4-6.
TABLE 3 evaluation criteria for striae gravidarum removal effect
TABLE 4 evaluation criteria for spreading of sample application
| Spreading property during application | Evaluation of spreading Property of coating |
| 1g sample development time < 2S | Easy to unfold |
| The 1g sample development time is 2-5S | Deployment in general |
| 1g sample development time > 5S | Hard to unfold |
TABLE 5 evaluation criteria for skin feel after sample application
| Skin feel after application | Evaluation of skin feel after application |
| After being smeared, the paint is breathable and has no greasy feeling after being lightly wiped by hands | Clear and penetrate |
| After being smeared, the paint is breathable or slightly non-breathable, and has greasy feeling after being lightly wiped by hands | Slightly greasy |
| After being smeared, the paint is not breathable, and the paint feels greasy after being lightly wiped by hands | Is relatively greasy |
TABLE 6 Desorption of striae gravidarum results for test A (Unit: example)
TABLE 7 sample application experience evaluation results of test content A (Unit: case)
TABLE 8 striae gravidarum removal results for test B (Unit: example)
TABLE 9 striae gravidarum removal results for test C (Unit: example)
Claims (8)
1. A pregnant streak massage lotion is characterized by comprising a first component, a second component, a third component and a fourth component; wherein,
the first component comprises water, disodium EDTA and a humectant;
the second component comprises PEG-60 sorbitan stearate and a softening agent;
the third component comprises water and acrylic/C10-30 alkanol acrylate crosspolymer;
the fourth component comprises acetyl hexapeptide-8, acetyl tripeptide-30 citrulline and pentapeptide;
the humectant comprises 3-5 wt% of triethanolamine, 2-3 wt% of hyaluronic acid, 55-60 wt% of glycerol and 32-40 wt% of dipropylene glycol; the softening agent comprises 1-2 wt% of stearic acid, 2-4 wt% of glyceryl stearate, 2-4 wt% of polydimethylsiloxane, 50-60 wt% of dioctyl carbonate, 20-25 wt% of caprylic/capric triglyceride, 2-4 wt% of crab apple seed oil, 5-10 wt% of isononyl isononanoate and 8-15 wt% of cetyl alcohol ethyl hexanoate.
2. The pregnancy line massage cream of claim 1, characterized in that the dosage ratio of the first component, the second component, the third component and the fourth component is 18-22: 19-23: 10-13: 1;
in the first component, the dosage ratio of water, EDTA disodium and humectant is 1: 0.1% -0.2%: 0.25 to 0.35;
in the second component, the dosage ratio of PEG-60 sorbitan stearate to the softening agent is 3-6%: 1;
in the third component, the dosage ratio of water to acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer is 1: 0.8% -2%;
in the fourth component, the dosage ratio of acetyl hexapeptide-8, acetyl tripeptide-30 citrulline and pentapeptide is 1: 0.5-1.5: 0.5 to 1.5.
3. The pregnancy line massage cream of claim 2, wherein the fourth component further comprises a preservative and a perfume; according to the mass ratio of the acetyl hexapeptide-8 to the preservative to the essence is 1: 0.2-0.5: 0.1 to 0.2.
4. The pregnancy line massage cream of claim 2, wherein the hyaluronic acid comprises Mr of (1-2) x 106HAs a value of (1-8). times.10 for HA and Mr4The HA of (1).
5. A method for preparing the pregnancy line massage cream of any one of claims 1 to 4, comprising the steps of:
step 1: mixing the raw materials of the first component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed first component;
step 2: mixing the raw materials of the second component according to the formula amount, stirring and heating to 70-75 ℃ to obtain a uniformly dispersed second component;
and step 3: mixing the raw materials of the third component according to the formula amount, and stirring to obtain a uniformly dispersed third component;
and 4, step 4: mixing the raw materials of the fourth component according to the formula amount, and stirring to obtain a uniformly dispersed fourth component;
and 5: under the heat preservation state, adding the second component obtained by the treatment in the step 2 into the first component obtained in the step 1, homogenizing and uniformly dispersing; then, under the heat preservation state, adding the third component obtained by the treatment in the step 3, homogenizing and uniformly dispersing; cooling the material body to 42-45 ℃, adding the fourth component obtained by the treatment in the step 4, homogenizing and uniformly dispersing; and cooling to 25-30 ℃ to obtain the product.
6. The method for preparing pregnancy line massage cream of claim 5, wherein,
according to the mass, the dosage ratio of the first component to the second component to the third component to the fourth component is 18-22: 19-23: 10-13: 1;
the first component comprises water, disodium EDTA and a humectant; in the first component, the dosage ratio of water, EDTA disodium and humectant is 1: 0.1% -0.2%: 0.25 to 0.35; the humectant comprises 3-5 wt% of triethanolamine, 2-3 wt% of hyaluronic acid, 55-60 wt% of glycerol and 32-40 wt% of dipropylene glycol; the hyaluronic acid comprises Mr of (1-2) x 106HAs a value of (1-8). times.10 for HA and Mr4The HA of (a);
the second component comprises PEG-60 sorbitan stearate and a softening agent; in the second component, the dosage ratio of PEG-60 sorbitan stearate to the softening agent is 3-6%: 1; the softening agent comprises 1-2 wt% of stearic acid, 2-4 wt% of glyceryl stearate, 2-4 wt% of polydimethylsiloxane, 50-60 wt% of dioctyl carbonate, 20-25 wt% of caprylic/capric triglyceride, 2-4 wt% of crab apple seed oil, 5-10 wt% of isononyl isononanoate and 8-15 wt% of cetyl ethyl hexanoate;
the third component comprises water and acrylic acid/C10-30 alkanol acrylate cross-linked polymer, and the dosage ratio of the water and the acrylic acid/C10-30 alkanol acrylate cross-linked polymer in the third component is 1: 0.8% -2%;
the fourth component comprises acetyl hexapeptide-8, acetyl tripeptide-30 citrulline, pentapeptide, preservative and essence, and in the fourth component, the dosage ratio of the acetyl hexapeptide-8, the acetyl tripeptide-30 citrulline, the pentapeptide, the preservative and the essence is 1: 0.5-1.5: 0.5-1.5: 0.2-0.5: 0.1 to 0.2.
7. The preparation method of the pregnant streaky massage cream as claimed in claim 6, wherein the crab apple seed oil is prepared by the following method:
taking crabapple seeds, adding an ethanol water solution, performing heat preservation and ultrasonic extraction for 0.5-2 hr at the temperature of 5-30 ℃, extracting for 2-3 times, combining extract liquor, filtering, and performing heat preservation and concentration at the temperature of 5-30 ℃ to obtain an alcohol extract; and adding water into the concentrated alcohol extract, extracting, and volatilizing the solvent at 5-30 ℃ to obtain the alcohol extract.
8. The preparation method of the pregnant streaky massage cream as claimed in claim 7, wherein the crab apple seed raw material is pretreated by drying and crushing, wherein the drying is freeze drying at-20 to 0 ℃, and the crushing is heat preservation crushing at 5 to 30 ℃; the ethanol aqueous solution comprises 75-90 wt% of ethanol and 10-25 wt% of water, the weight ratio of the dry weight of the Chinese flowering crabapple seeds to the amount of the ethanol aqueous solution used for extraction is 1: 2-5, and the weight ratio of the concentrated ethanol extract to the water is 1: 2-5.
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| CN104069043A (en) * | 2014-07-23 | 2014-10-01 | 上海岚瑞电子商务有限公司 | Massage gel for preventing striae gravidarum and preparation method thereof |
| CN105267243A (en) * | 2014-07-23 | 2016-01-27 | 深圳天元干细胞科技有限公司 | Stem cell extract product for eliminating skin striae gravidarum |
| CN104921983A (en) * | 2015-05-25 | 2015-09-23 | 广西达庆生物科技有限公司 | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof |
| JP2016056205A (en) * | 2016-01-14 | 2016-04-21 | 花王株式会社 | Mfap-4 production promoter |
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| CN105963156A (en) | 2016-09-28 |
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