CN105963156A - Pregnancy line massage lotion and method for preparing same - Google Patents
Pregnancy line massage lotion and method for preparing same Download PDFInfo
- Publication number
- CN105963156A CN105963156A CN201610485100.7A CN201610485100A CN105963156A CN 105963156 A CN105963156 A CN 105963156A CN 201610485100 A CN201610485100 A CN 201610485100A CN 105963156 A CN105963156 A CN 105963156A
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- component
- pregnant
- stricture
- water
- amount ratio
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- 238000000034 method Methods 0.000 title claims description 27
- 230000035935 pregnancy Effects 0.000 title abstract description 9
- 239000006210 lotion Substances 0.000 title abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 150000002148 esters Chemical class 0.000 claims abstract description 19
- 239000000080 wetting agent Substances 0.000 claims abstract description 17
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims abstract description 12
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 9
- -1 melon amino acid Chemical class 0.000 claims abstract description 8
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 38
- 210000001215 vagina Anatomy 0.000 claims description 38
- 239000006071 cream Substances 0.000 claims description 34
- 239000002994 raw material Substances 0.000 claims description 28
- 240000005589 Calophyllum inophyllum Species 0.000 claims description 22
- 235000009590 Calophyllum inophyllum Nutrition 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
- QWVUXEBWAZOACQ-UHFFFAOYSA-N 2-(hydroxymethyl)-2-[[2-hydroxy-3-(16-methylheptadecoxy)propoxy]methyl]propane-1,3-diol Chemical compound CC(C)CCCCCCCCCCCCCCCOCC(O)COCC(CO)(CO)CO QWVUXEBWAZOACQ-UHFFFAOYSA-N 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- 238000000605 extraction Methods 0.000 claims description 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 13
- 229920002674 hyaluronan Polymers 0.000 claims description 13
- 229960003160 hyaluronic acid Drugs 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 12
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 9
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims description 9
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 9
- 235000013477 citrulline Nutrition 0.000 claims description 9
- 229960002173 citrulline Drugs 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 7
- HVUMOYIDDBPOLL-XGKPLOKHSA-N [2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XGKPLOKHSA-N 0.000 claims description 7
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 6
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 claims description 6
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 6
- 235000021355 Stearic acid Nutrition 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 229940075529 glyceryl stearate Drugs 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 5
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000008117 stearic acid Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 230000008901 benefit Effects 0.000 abstract description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- UHGGERUQGSJHKR-VCDGYCQFSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;octadecanoic acid Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCCCCCCCCCCCC(O)=O UHGGERUQGSJHKR-VCDGYCQFSA-N 0.000 abstract 1
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
- 241000219112 Cucumis Species 0.000 abstract 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 abstract 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 abstract 1
- 239000004902 Softening Agent Substances 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 abstract 1
- 125000005233 alkylalcohol group Chemical group 0.000 abstract 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 abstract 1
- 229960001484 edetic acid Drugs 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 21
- 235000019198 oils Nutrition 0.000 description 21
- 206010040925 Skin striae Diseases 0.000 description 20
- 239000000047 product Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 9
- 208000007502 anemia Diseases 0.000 description 7
- 238000011156 evaluation Methods 0.000 description 7
- 239000000523 sample Substances 0.000 description 6
- 241000717739 Boswellia sacra Species 0.000 description 4
- 239000004863 Frankincense Substances 0.000 description 4
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 4
- 210000000582 semen Anatomy 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 230000003187 abdominal effect Effects 0.000 description 3
- 239000013068 control sample Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 241000207199 Citrus Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 239000008163 avocado oil Substances 0.000 description 2
- 235000021302 avocado oil Nutrition 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 235000000983 citronellal Nutrition 0.000 description 2
- 229930003633 citronellal Natural products 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 201000010251 cutis laxa Diseases 0.000 description 2
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 2
- 229940093633 tricaprin Drugs 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 101001018064 Homo sapiens Lysosomal-trafficking regulator Proteins 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102100033472 Lysosomal-trafficking regulator Human genes 0.000 description 1
- 244000038561 Modiola caroliniana Species 0.000 description 1
- 235000010703 Modiola caroliniana Nutrition 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 210000000579 abdominal fat Anatomy 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229950011392 sorbitan stearate Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses pregnancy line massage lotion. The pregnancy line massage lotion comprises first components, second components, third components and fourth components. The first components comprise water, disodium EDTA (ethylene diamine tetraacetic acid) and humectants; the second components comprise PEG-60 dehydrated sorbitol stearate and softening and wetting agents; the third components comprise water and acrylic acid (ester)/C10-30 alkyl alcohol acrylate cross-linked polymers; the fourth components comprise acetyl hexapeptide-8, acetyl tripeptide-30 melon amino acid and pentapeptide. The pregnancy line massage lotion has the advantage of effects of reducing the quality difference of products.
Description
Technical field
The present invention relates to skin care industry, particularly to a kind of pregnant stricture of vagina massage cream and preparation method thereof.
Background technology
Pregnant stricture of vagina, refers to occur in skin and excessively expands bar or the band of skin after changing with hormone.Women is pregnant
Your twilight of period load-bearing of being pregnent is rung, and abdominal tympanites makes the elastic fibers of skin and collagen fiber be subject in various degree because of external force tractive
Damage or fracture, thinning of skin attenuates, and abdominal skin is thinning to attenuate, and abdominal skin there will be that some width are different, length
The pink differed or mauve wavy decorative pattern；After childbirth, these decorative patterns can fade away, and leaves white or silvery white
The shallow trace of cicatrix.Pregnant stricture of vagina is not easily vanished, and it makes the skin of women lax, fold, abdominal fat accumulation, breast occur
Tenesmus etc., have had a strong impact on figure and the physical and mental health in women puerperal.Jointly think in industry at present, the optimization process of pregnant stricture of vagina
Time is the period of gestation pregnant stricture of vagina just occurred；The most also there is a large amount of product processing pregnant stricture of vagina, wherein use quintessence oil to remove pregnant
Stricture of vagina is common mode.
The Chinese patent that application publication number is CN105534746A, Shen Qing Publication day is on May 4th, 2016 discloses
A kind of massage is with repairing striae gravidarum quintessence oil, and its raw material includes Semen pruni armeniacae oil, Semen Tritici aestivi germ oil, citronellal, peace yl benzoic acid first
Ester, silk polypeplide, hyaluronic acid, aminoacid, Cortex cocois radicis collagen protein, Fructus Citri tangerinae quintessence oil, Olibanum quintessence oil, orange blossom quintessence oil, smoked clothing
Grass quintessence oil, Citrus essential oil, Olibanum quintessence oil and Avocado Oil.
Being in place of the deficiencies in the prior art, it uses considerable amount of different quintessence oil to realize repairing the purpose of striae gravidarum,
But these quintessence oils exist the degree of volatility difference of volatile feature and different quintessence oil, this will result in the product quality deposited not
One, affect using effect.
Summary of the invention
The first object of the present invention is to provide a kind of pregnant stricture of vagina massage cream, which solves product and volatilizees the product quality caused not
The problem of one, has the effect reducing product quality diversity.
The above-mentioned technical purpose of the present invention has the technical scheme that
A kind of pregnant stricture of vagina massage cream, including the first component, the second component, the 3rd component and the 4th component；Wherein,
Described first component includes water, EDETATE SODIUM and wetting agent；
Described second component includes PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether；
3rd component includes water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer；
Described 4th component includes Argireline, acetyl group tripeptides-30 citrulline and pentapeptide.
Use technique scheme, Argireline, acetyl group tripeptides-30 citrulline and pentapeptide combination, impact
Melt bubble complex, reduce speed and the burst size of vesicle release neurotransmitters, thus weaken muscle contraction, reduce striae gravidarum and
The generation of wrinkle；It carries out nutritional supplementation to impaired skin simultaneously, can improve and reduce existing striae gravidarum after percutaneous absorption；
Utilize wetting agent and isostearyl glyceryl pentaerythrityl ether simultaneously, play lock water and the purpose of moisturizing, improve skin condition further；
Being provided without this kind of volatile material of quintessence oil in the technical scheme of the application, in product, the volatilization of each composition is negligible, and this Shen
Please be reduced the probability of each composition volatilization by the interaction between each composition further, make the product quality deposited steady
Fixed, it is ensured that using effect.
Research finds, by mass, and described first component, the second component, the 3rd component and the amount ratio of the 4th component
It is 18～22:19～23:10～13:1；
In described first component, the amount ratio of water, EDETATE SODIUM and wetting agent is 1:0.1%～0.2%:0.25～0.35；
In described second component, the amount ratio of PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether is 3%～6%:1；
In described 3rd component, the amount ratio of water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer is 1:
0.8%～2%；
In described 4th component, the amount ratio of Argireline, acetyl group tripeptides-30 citrulline and pentapeptide is 1:0.5～1.5:
0.5～1.5, its technical process and product quality can obtain optimal balance point.
More preferably: described wetting agent include the triethanolamine of 3wt%～5wt%, the hyaluronic acid of 2wt%～3wt%,
The glycerol of 55wt%～60wt% and the dipropylene glycol of 32wt%～40wt%.
Using technique scheme, synergy between triethanolamine, hyaluronic acid, glycerol and dipropylene glycol, from flesh
Carry out in the multilamellar of skin locking water moisturizing, and it is clear, it is adaptable to anemia of pregnant woman's use that body temperature is of a relatively high.
More preferably: described isostearyl glyceryl pentaerythrityl ether includes the glycerol stearate of the stearic acid of 1wt%～2wt%, 2wt%～4wt%
Ester, the polydimethylsiloxane of 2wt%～4wt%, the dicaprylyl carbonate of 50wt%～60wt%, the octanoic acid of 20wt%～25wt%
/ tricaprin, calophyllum inophyllum seed oil, the isononyl isononanoate of 5wt%～10wt% and 8wt%～15wt% of 2wt%～4wt%
Spermol ethylhexoate.
Use technique scheme, stearic acid, glyceryl stearate, polydimethylsiloxane, dicaprylyl carbonate, pungent
Acid/tricaprin, calophyllum inophyllum seed oil, isononyl isononanoate and spermol ethylhexoate synergy, viscosity reduction and bending
Take a little, improve mobility and the surface tension of emulsion system, easily dispersion and easily preparation, obtain finely dispersed emulsus and this breast
Shape is stable；After these isostearyl glyceryl pentaerythrityl ether synergy, when smearing, extensibility is good and easily promotes that the pregnant stricture of vagina massage cream of the application absorbs, and makes
Obtaining skin smooth, soft and moist, high resilience, skinfeel is clear.
More preferably: described 4th component also includes preservative and essence；By mass, described Argireline,
The amount ratio of preservative and essence is 1:0.2～0.5:0.1～0.2.
Use technique scheme, increase service life and the fragrance of regulation product of product, improve the suitability of product.
More preferably: described hyaluronic acid includes that Mr is (1～2) × 106HA and Mr be (1～8) ×
104HA.
Using technique scheme, micromolecule hyaluronic acid entrance skin is to internal layer moisturizing, and macromole hyaluronic acid position
Carry out skin surface locking water and water suction in skin is outer, improve moisture content of skin.
The second object of the present invention is to provide the preparation method of described pregnant stricture of vagina massage cream.
The above-mentioned technical purpose of the present invention has the technical scheme that
The preparation method of a kind of described pregnant stricture of vagina massage cream, comprises the steps:
Step 1: each raw material of the first component is pressed formula ratio mixing, is heated with stirring to 70～75 DEG C, obtains finely dispersed first
Component；
Step 2: each raw material of the second component is pressed formula ratio mixing, is heated with stirring to 70～75 DEG C, obtains finely dispersed second
Component；
Step 3: each raw material of the 3rd component is pressed formula ratio mixing, stirring, obtains finely dispersed 3rd component；
Step 4: each raw material of the 4th component is pressed formula ratio mixing, stirring, obtains finely dispersed 4th component；
Step 5: under keeping warm mode, adds in the first component that step 1 obtains and processes, through step 2, the second component obtained, all
Matter, is uniformly dispersed；Afterwards under keeping warm mode, process the 3rd component obtained, homogenizing in wherein adding through step 3, divide
Dissipate uniformly；Afterwards material body is cooled to 42～45 DEG C, then at wherein adding the 4th component obtained through step 4 process, homogenizing,
It is uniformly dispersed；It is cooled to 25～30 DEG C afterwards, to obtain final product.
Use technique scheme, during easily disperse and keep each raw material activity, the good product dispersibility that obtains and easily
Launch.
Research finds, by mass, and described first component, the second component, the 3rd component and the amount ratio of the 4th component
It is 18～22:19～23:10～13:1；
Described first component includes water, EDETATE SODIUM and wetting agent；In first component, the use of water, EDETATE SODIUM and wetting agent
Amount ratio is 1:0.1%～0.2%:0.25～0.35；Described wetting agent includes the triethanolamine of 3wt%～5wt%, 2wt%～3wt%
Hyaluronic acid, the glycerol of 55wt%～60wt% and the dipropylene glycol of 32wt%～40wt%；Described hyaluronic acid includes Mr
For (1～2) × 106HA and Mr be (1～8) × 104HA；
Described second component includes PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether；In described second component, PEG-60 loses
The amount ratio of water sorbitan stearate and isostearyl glyceryl pentaerythrityl ether is 3%～6%:1；Described isostearyl glyceryl pentaerythrityl ether includes the tristearin of 1wt%～2wt%
Acid, the glyceryl stearate of 2wt%～4wt%, the polydimethylsiloxane of 2wt%～4wt%, the carbonic acid of 50wt%～60wt%
Dioctyl ester, the caprylic/capric triglyceride of 20wt%～25wt%, the calophyllum inophyllum seed oil of 2wt%～4wt%, 5wt%～10wt%
Isononyl isononanoate and the spermol ethylhexoate of 8wt%～15wt%；
3rd component includes in water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, and described 3rd component,
The amount ratio of water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer is 1:0.8%～2%；
Described 4th component includes Argireline, acetyl group tripeptides-30 citrulline, pentapeptide, preservative and essence, and described
In 4th component, the amount ratio of Argireline, acetyl group tripeptides-30 citrulline, pentapeptide, preservative and essence is 1:
0.5～1.5:0.5～1.5:0.2～0.5:0.1～0.2, its technical process and product quality can obtain optimal balance point.
More preferably: described calophyllum inophyllum seed oil prepares by the following method:
Take calophyllum inophyllum seed, add ethanol water, at 5～30 DEG C, be incubated ultrasonic 0.5～2hr extract, extract 2～3 times, merge
Lixiviating solution, filters and insulation is concentrated to give alcohol extraction thing at 5～30 DEG C；Alcohol extraction thing after concentrating adds water, extraction
At 5～30 DEG C, volatilize solvent after taking, to obtain final product.
Using technique scheme, low-temperature operation can keep the biological activity of calophyllum inophyllum seed, simultaneously by said method system
The standby calophyllum inophyllum seed oil yield obtained is high, soothing effect is more preferable；Use the calophyllum inophyllum seed oil volatilizing solvent, non-stimulated, it is suitable for
In anemia of pregnant woman.
More preferably: described calophyllum inophyllum seed raw material drying and comminution pretreatment, described it is dried as cold at-20～0 DEG C
Freeze dry, pulverize be at 5～30 DEG C insulation pulverize；Described ethanol water by the ethanol of 75wt%～90wt% and
The water of 10wt%～25wt% is constituted, and the dry weight of the most described calophyllum inophyllum seed and ethanol water used by extraction every time
Amount ratio be 1:2～5, alcohol extraction thing and the quality amount ratio of water after described concentration are 1:2～5.
Use technique scheme, first with lyophilization, raw material processed so that raw material moment dehydration and originally also
Substantially hold its shape state, and it is easily pulverized and can be with Extraction solvent energy snap action to accelerate the dissolution of the effective ingredient in raw material.
In sum, the method have the advantages that
1, the raw material that the application uses is the most non-stimulated or do not produces zest product after low stimulation, and its mixing, and its gentleness is non-stimulated,
It is applicable to anemia of pregnant woman and puerpera uses；
2, the pregnant stricture of vagina massage cream of the application goes striae gravidarum speed faster and effect is more preferable, and it is applicable to the anemia of pregnant woman of intermediary and later stages in pregnancy period
And puerpera；
3, after using the pregnant stricture of vagina massage cream of the application, skinfeel is more clear, and extensibility is smeared in raising；
4, use the application pregnant stricture of vagina massage cream after skin more consolidation, the situation of cutis laxa can be improved, make skin more glossy and
High resilience.
Detailed description of the invention
Indicating unless special, raw material used herein all meets international cosmetic raw material standard, the most in this application
The unreceipted source of single component.This specific embodiment is only explanation of the invention, and it is not limitation of the present invention,
The present embodiment can be made after reading this specification by those skilled in the art as required does not has creative contribution to repair
Change, but as long as all being protected by Patent Law in scope of the presently claimed invention.
Embodiment 1-3: calophyllum inophyllum seed is oily, it prepares by the following method:
Pretreatment: take calophyllum inophyllum seed raw material, at-20～0 DEG C, lyophilization is to constant weight, and at 5～30 DEG C, insulating powder is broken to 100～200
Mesh；
Extract: take pretreated calophyllum inophyllum seed, add ethanol water, at 5～30 DEG C, be incubated ultrasonic 0.5～2hr extract,
Extract 2～3 times, merge lixiviating solution, filter and insulation is concentrated to give alcohol extraction thing at 5～30 DEG C；Alcohol extraction after concentrating
Take addition water in thing, at 5～30 DEG C, volatilize solvent after extraction, to obtain final product；
The raw material information of embodiment 1-3 is as shown in table 1.
Each raw material information in the calophyllum inophyllum seed oil of table 1 embodiment 1-3
Embodiment 4-6: pregnant stricture of vagina massage cream, it prepares by the following method:
Step 1: each raw material of the first component is pressed formula ratio mixing, is heated with stirring to 70～75 DEG C, obtains finely dispersed first
Component；
Step 2: each raw material of the second component is pressed formula ratio mixing, is heated with stirring to 70～75 DEG C, obtains finely dispersed second
Component；
Step 3: each raw material of the 3rd component is pressed formula ratio mixing, stirring, obtains finely dispersed 3rd component；
Step 4: each raw material of the 4th component is pressed formula ratio mixing, stirring, obtains finely dispersed 4th component；
Step 5: under keeping warm mode, adds in the first component that step 1 obtains and processes, through step 2, the second component obtained, all
Matter, is uniformly dispersed；Afterwards under keeping warm mode, process the 3rd component obtained, homogenizing in wherein adding through step 3, divide
Dissipate uniformly；Afterwards material body is cooled to 42～45 DEG C, then at wherein adding the 4th component obtained through step 4 process, homogenizing,
It is uniformly dispersed；It is cooled to 25～30 DEG C afterwards, to obtain final product；
The raw material information of embodiment 4-6 is as shown in table 2.
Each raw material information in the pregnant stricture of vagina massage cream of table 2 embodiment 4-6
Embodiment 7: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, and its calophyllum inophyllum seed oil is carried by French green section
Supply.
Embodiment 8: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the wetting agent of the first component, and glycerol
Substitute with dipropylene glycol.
Embodiment 9: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the wetting agent of the first component, and double third
Glycol glycerol substitutes.
Embodiment 10: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the wetting agent of the first component, not
Add triethanolamine, Mr is (1～2) × 106HA and Mr be (1～8) × 104HA.
Embodiment 11: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the isostearyl glyceryl pentaerythrityl ether of the second component, not
Add stearic acid, glyceryl stearate and polydimethylsiloxane.
Embodiment 12: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the isostearyl glyceryl pentaerythrityl ether of the second component, not
Add isononyl isononanoate and spermol ethylhexoate.
Embodiment 13: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, in the isostearyl glyceryl pentaerythrityl ether of the second component, not
Add caprylic/capric triglyceride and calophyllum inophyllum seed oil.
Embodiment 14: pregnant stricture of vagina massage cream, is with the difference of embodiment 5, and all raw materials are in room temperature (25 DEG C)
The most directly stir mixing, stir 2hr, to obtain final product.
Embodiment 15: massage is with repairing striae gravidarum quintessence oil, and prepared by the embodiment 1 with reference to CN105534746A, take 50g
Semen pruni armeniacae oil, 8g Semen Tritici aestivi germ oil, 1g citronellal, 1g peace yl benzoic acid methyl ester, 1.5g silk polypeplide, 0.5g hyaluronic acid,
2g lysine, 2g Cortex cocois radicis collagen protein, 9g Fructus Citri tangerinae quintessence oil, 2g Olibanum quintessence oil, 2g orange blossom quintessence oil, 2g Garden lavender quintessence oil,
13g Citrus essential oil, 5g Olibanum quintessence oil and 1g Avocado Oil, directly stir mixing under room temperature (25 DEG C), be uniformly dispersed,
Obtain.
Embodiment 16: in-service evaluation
Subjects: with embodiment 4-14 as test specimen, with embodiment 15 as control sample.
Content of the test A: selecting 120 pregnancy periods at random is individual month of 3-6 and the anemia of pregnant woman having slight striae gravidarum (pinkiness),
Being randomly divided into 12 groups, often 10 people of group, often group uses a subjects；Frequency is used to be 3 times/day；Respectively at
Use 1 week and after 1 month by table 3 to going striae gravidarum effect to be evaluated, carry out smearing experience by table 4 and table 5 simultaneously
Evaluate；
Content of the test B: select 120 pregnancy periods to be 6-10 month and have the anemia of pregnant woman of obvious striae gravidarum (in aubergine or black) at random,
Being randomly divided into 12 groups, often 10 people of group, often group uses a subjects；Frequency is used to be 3 times/day；Respectively at
Use 1 week and after 1 month by table 3 to going striae gravidarum effect to be evaluated；
Content of the test C: select 120 puerperas produced in 1 month and have obvious striae gravidarum (in black) at random, be randomly divided into
12 groups, often 10 people of group, often group uses a subjects；Frequency is used to be 3 times/day；Respectively at using 1 week
With 1 month after by table 3 to going striae gravidarum effect to be evaluated；
Result of the test: striae gravidarum removal effect, as shown in table 6,8 and 9, is smeared experience and evaluated as shown in table 7.
Table 6,8 with 9 display: compare control sample, the pregnant stricture of vagina massage cream of embodiment 4-14 go striae gravidarum speed faster and
Effect is more preferable, particularly after using the massage cream one month of embodiment 4-6 can striae gravidarum is thin out and range shorter 50% with
On；The pregnant stricture of vagina massage cream of embodiment 4-14 go anemia of pregnant woman and the puerpera that striae gravidarum is applicable to the intermediary and later stages in pregnancy period.
Table 7 shows: compare control sample, and it is more clear to smear the skinfeel after embodiment 4-14, and smear extensibility general or
Easily launch, particularly easily launch after the massage cream using embodiment 4-6 and skinfeel is clear.
Meanwhile, research finds, uses skin more consolidation after embodiment 4-14, can improve the situation of cutis laxa, make skin
Skin is more glossy and high resilience；And use the skin improvement effects after embodiment 4-6 optimal.
Table 3 striae gravidarum removal effect evaluation criterion
Extensibility evaluation criterion smeared by table 4 sample
| Extensibility when smearing | Smear extensibility evaluation |
| 1g sample duration of run ＜ 2S | Easily launch |
| 1g sample duration of run is 2～5S | Launch general |
| 1g sample duration of run ＞ 5S | Difficult expansion |
Table 5 sample smear after skinfeel evaluation criterion
| Skinfeel after smearing | Smear rear skinfeel evaluation |
| Breathe freely after smearing and gently wipe not without greasy feeling with hands | Clear |
| Breathe freely or the most airtight after smearing, and gently wiped greasy feeling with hands | The most greasy |
| Smear rear airtight, and gently wiped greasy feeling with hands | The most greasy |
Table 6 content of the test A go striae gravidarum result (unit: example)
Experience evaluation result (unit: example) smeared by the sample of table 7 content of the test A
Table 8 content of the test B go striae gravidarum result (unit: example)
Table 9 content of the test C go striae gravidarum result (unit: example)
Claims (10)
1. a pregnant stricture of vagina massage cream, it is characterised in that include the first component, the second component, the 3rd component and the 4th component；Wherein,
Described first component includes water, EDETATE SODIUM and wetting agent；
Described second component includes PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether；
3rd component includes water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer；
Described 4th component includes Argireline, acetyl group tripeptides-30 citrulline and pentapeptide.
Pregnant stricture of vagina massage cream the most according to claim 1, it is characterised in that by mass, the amount ratio of described first component, the second component, the 3rd component and the 4th component is 18 ~ 22:19 ~ 23:10 ~ 13:1；
In described first component, the amount ratio of water, EDETATE SODIUM and wetting agent is 1:0.1% ~ 0.2%:0.25 ~ 0.35；
In described second component, the amount ratio of PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether is 3% ~ 6%:1；
In described 3rd component, the amount ratio of water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer is 1:0.8% ~ 2%；
In described 4th component, the amount ratio of Argireline, acetyl group tripeptides-30 citrulline and pentapeptide is 1:0.5 ~ 1.5:0.5 ~ 1.5.
Pregnant stricture of vagina massage cream the most according to claim 2, it is characterised in that described wetting agent includes the triethanolamine of 3wt% ~ 5wt%, the hyaluronic acid of 2wt% ~ 3wt%, the glycerol of 55wt% ~ 60wt% and the dipropylene glycol of 32wt% ~ 40wt%.
Pregnant stricture of vagina massage cream the most according to claim 2, it is characterized in that, described isostearyl glyceryl pentaerythrityl ether includes calophyllum inophyllum seed oil, the isononyl isononanoate of 5wt% ~ 10wt% and the spermol ethylhexoate of 8wt% ~ 15wt% of the stearic acid of 1wt% ~ 2wt%, the glyceryl stearate of 2wt% ~ 4wt%, the polydimethylsiloxane of 2wt% ~ 4wt%, the dicaprylyl carbonate of 50wt% ~ 60wt%, the caprylic/capric triglyceride of 20wt% ~ 25wt%, 2wt% ~ 4wt%.
Pregnant stricture of vagina massage cream the most according to claim 2, it is characterised in that described 4th component also includes preservative and essence；By mass, the amount ratio of described Argireline, preservative and essence is 1:0.2 ~ 0.5:0.1 ~ 0.2.
Pregnant stricture of vagina massage cream the most according to claim 3, it is characterised in that described hyaluronic acid includes that Mr is (1 ~ 2) × 106HA and Mr be (1 ~ 8) × 104HA.
7. the preparation method of the pregnant stricture of vagina massage cream as described in any one of claim 1-6, it is characterised in that comprise the steps:
Step 1: each raw material of the first component is pressed formula ratio mixing, is heated with stirring to 70 ~ 75 DEG C, obtains finely dispersed first component；
Step 2: each raw material of the second component is pressed formula ratio mixing, is heated with stirring to 70 ~ 75 DEG C, obtains finely dispersed second component；
Step 3: each raw material of the 3rd component is pressed formula ratio mixing, stirring, obtains finely dispersed 3rd component；
Step 4: each raw material of the 4th component is pressed formula ratio mixing, stirring, obtains finely dispersed 4th component；
Step 5: under keeping warm mode, adds in the first component that step 1 obtains and processes the second component obtained, homogenizing through step 2, be uniformly dispersed；Afterwards under keeping warm mode, process the 3rd component obtained, homogenizing in wherein adding through step 3, be uniformly dispersed；Afterwards material body is cooled to 42 ~ 45 DEG C, processes the 4th component obtained, homogenizing then at wherein adding through step 4, be uniformly dispersed；It is cooled to 25 ~ 30 DEG C afterwards, to obtain final product.
The preparation method of pregnant stricture of vagina massage cream the most according to claim 7, it is characterised in that
By mass, the amount ratio of described first component, the second component, the 3rd component and the 4th component is 18 ~ 22:19 ~ 23:10 ~ 13:1；
Described first component includes water, EDETATE SODIUM and wetting agent；In first component, the amount ratio of water, EDETATE SODIUM and wetting agent is 1:0.1% ~ 0.2%:0.25 ~ 0.35；Described wetting agent includes the triethanolamine of 3wt% ~ 5wt%, the hyaluronic acid of 2wt% ~ 3wt%, the glycerol of 55wt% ~ 60wt% and the dipropylene glycol of 32wt% ~ 40wt%；Described hyaluronic acid includes that Mr is (1 ~ 2) × 106HA and Mr be (1 ~ 8) × 104HA；
Described second component includes PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether；In described second component, the amount ratio of PEG-60 Span60 and isostearyl glyceryl pentaerythrityl ether is 3% ~ 6%:1；Described isostearyl glyceryl pentaerythrityl ether includes calophyllum inophyllum seed oil, the isononyl isononanoate of 5wt% ~ 10wt% and the spermol ethylhexoate of 8wt% ~ 15wt% of the stearic acid of 1wt% ~ 2wt%, the glyceryl stearate of 2wt% ~ 4wt%, the polydimethylsiloxane of 2wt% ~ 4wt%, the dicaprylyl carbonate of 50wt% ~ 60wt%, the caprylic/capric triglyceride of 20wt% ~ 25wt%, 2wt% ~ 4wt%；
3rd component includes that, in water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer, and described 3rd component, the amount ratio of water and acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross linked polymer is 1:0.8% ~ 2%；
Described 4th component includes Argireline, acetyl group tripeptides-30 citrulline, pentapeptide, preservative and essence; and in described 4th component, the amount ratio of Argireline, acetyl group tripeptides-30 citrulline, pentapeptide, preservative and essence is 1:0.5 ~ 1.5:0.5 ~ 1.5:0.2 ~ 0.5:0.1 ~ 0.2.
The preparation method of pregnant stricture of vagina massage cream the most according to claim 8, it is characterised in that described calophyllum inophyllum seed oil prepares by the following method:
Take calophyllum inophyllum seed, add ethanol water, at 5 ~ 30 DEG C, be incubated ultrasonic 0.5 ~ 2hr extract, extract 2 ~ 3 times, merge lixiviating solution, filter and insulation is concentrated to give alcohol extraction thing at 5 ~ 30 DEG C；Alcohol extraction thing after concentrating adds water, at 5 ~ 30 DEG C, volatilizes solvent after extraction, to obtain final product.
The preparation method of pregnant stricture of vagina massage cream the most according to claim 9, it is characterised in that described calophyllum inophyllum seed raw material drying and comminution pretreatment, described is dried as lyophilization at-20 ~ 0 DEG C, and pulverizing is that at 5 ~ 30 DEG C, insulation is pulverized；Described ethanol water is made up of the ethanol of 75wt% ~ 90wt% and the water of 10wt% ~ 25wt%, and the amount ratio of the dry weight of the most described calophyllum inophyllum seed and ethanol water used by extraction every time is 1:2 ~ 5, alcohol extraction thing and the quality amount ratio of water after described concentration are 1:2 ~ 5.
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|---|---|---|---|---|
| CN112274437A (en) * | 2020-11-30 | 2021-01-29 | 广州市柏菲化妆品有限公司 | Massage cream and preparation method thereof |
| CN113633577A (en) * | 2021-08-16 | 2021-11-12 | 广州常青藤化妆品有限公司 | Emulsifiable paste and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102341A1 (en) * | 2001-06-14 | 2002-12-27 | Alfred Denner | Cosmetic treatment method for stretch marks |
| US20070280898A1 (en) * | 2006-06-06 | 2007-12-06 | P & H Enterprises Of Marco Inc. | Dermatological compositions |
| WO2008080443A2 (en) * | 2007-01-04 | 2008-07-10 | Labo Cosprophar Ag | Cosmetic composition for the treatment and/or prevention of skin stretch marks |
| CN104069043A (en) * | 2014-07-23 | 2014-10-01 | 上海岚瑞电子商务有限公司 | Massage gel for preventing striae gravidarum and preparation method thereof |
| CN104921983A (en) * | 2015-05-25 | 2015-09-23 | 广西达庆生物科技有限公司 | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof |
| KR20150115186A (en) * | 2014-04-03 | 2015-10-14 | 심지영 | Cosmetic composition for anti-stretch mark effect on the skin with the extract of Olea europaea leaf |
| CN105267243A (en) * | 2014-07-23 | 2016-01-27 | 深圳天元干细胞科技有限公司 | Stem cell extract product for eliminating skin striae gravidarum |
| JP2016056205A (en) * | 2016-01-14 | 2016-04-21 | 花王株式会社 | Mfap-4 production promoter |
-
2016
- 2016-06-23 CN CN201610485100.7A patent/CN105963156B/en not_active Expired - Fee Related
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002102341A1 (en) * | 2001-06-14 | 2002-12-27 | Alfred Denner | Cosmetic treatment method for stretch marks |
| US20070280898A1 (en) * | 2006-06-06 | 2007-12-06 | P & H Enterprises Of Marco Inc. | Dermatological compositions |
| WO2008080443A2 (en) * | 2007-01-04 | 2008-07-10 | Labo Cosprophar Ag | Cosmetic composition for the treatment and/or prevention of skin stretch marks |
| KR20150115186A (en) * | 2014-04-03 | 2015-10-14 | 심지영 | Cosmetic composition for anti-stretch mark effect on the skin with the extract of Olea europaea leaf |
| CN104069043A (en) * | 2014-07-23 | 2014-10-01 | 上海岚瑞电子商务有限公司 | Massage gel for preventing striae gravidarum and preparation method thereof |
| CN105267243A (en) * | 2014-07-23 | 2016-01-27 | 深圳天元干细胞科技有限公司 | Stem cell extract product for eliminating skin striae gravidarum |
| CN104921983A (en) * | 2015-05-25 | 2015-09-23 | 广西达庆生物科技有限公司 | Medical biological repairing dressing for pregnant woman striae gravidarum and preparation method thereof |
| JP2016056205A (en) * | 2016-01-14 | 2016-04-21 | 花王株式会社 | Mfap-4 production promoter |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274437A (en) * | 2020-11-30 | 2021-01-29 | 广州市柏菲化妆品有限公司 | Massage cream and preparation method thereof |
| CN113633577A (en) * | 2021-08-16 | 2021-11-12 | 广州常青藤化妆品有限公司 | Emulsifiable paste and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN105963156B (en) | 2019-03-05 |
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