CN106668937A - Bionic skin and preparation method thereof - Google Patents
Bionic skin and preparation method thereof Download PDFInfo
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- CN106668937A CN106668937A CN201611167553.1A CN201611167553A CN106668937A CN 106668937 A CN106668937 A CN 106668937A CN 201611167553 A CN201611167553 A CN 201611167553A CN 106668937 A CN106668937 A CN 106668937A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention relates to the field of makeups, in particular to bionic skin. The bionic skin is prepared by performing emulsion polymerization on a basic reactant, an assistant and water to form a crosslinking netlike structure under the catalytic action of a catalyst. The scheme has the advantages that the existing document literature records indicate that the components in the formula of the bionic skin have high security and biocompatibility, and are free from sensitization and inflammation; the components have property viscosity, can be applied to the skin surface uniformly, and are easy for film formation; the components have excellent biomechanical properties such as tensile modulus, viscosity and contractility; the components have high ventilation and moisture-keeping performance, washable performance and water resistance, and can block external harmful factors. The bionic skin prepared by the method is smooth on the surface, and is only 75 microns in thickness; added Nylon 10-12 has a good optical effect, so that the bionic skin can be perfectly combined with human body skin without any remarkable connection boundary line. The bionic skin prepared by the method has the effects of smoothening the skin, increasing skin elasticity and reducing wrinkles after being applied to the human skin.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of bionics skin and preparation method thereof.
Background technology
With the progress of scientific and technological level, quality of life of people also more and more higher.Pursuit of the people to U.S., especially to certainly
The beautiful pursuit of body appearance is more and more stronger.
Skin is one of most important organ of human body, is human body barrier together with the external world, protection tissue and organ
Do not encroached on by noxious substance, pathogen, microorganism in external environment etc., so as to maintain stablizing for interior environment, while having very
Permeability well and moisture retention, the physiological statuss of skin embody the health status of individuality.Aging, external environment infringement, disease etc.
Skin normal physiological function obstacle can be caused, and then cause quality of life decline, dysthymic disorder etc..Skin aging is for everyone
Meeting problems faced, aging causes skin to lose elastical retraction function and become lax, at present still without the method for radical cure.
For this purpose, tissue engineering gradually develops in recent years artificial bionic skin, the bionics skin of high-quality must have
Standby following characteristic:1) possesses biological safety, biocompatibility is high, is applied to skin not sensitization, does not produce inflammatory reaction;2) glue
Degree is suitable, easy film forming easy to apply in skin surface;3) air permeable humidity retaining and waterproof, stop the harmful factor of external environment；4) possess
The mechanics reaction of skin in the biomechanical property that normal skin possesses, such as tensile strength and elasticity, with daily routines matches；
5) smooth and thin, optical effect is good, is pasted onto normal skin surface, without obvious linkage interface, reaches effect attractive in appearance.But
Existing artificial skin still cannot completely possess feature and the physiologic properties that natural skin possesses.
The content of the invention
It is an object of the invention to provide a kind of bionics skin, it is intended to solve asking for existing bionics skin poor safety performance
Topic.
What the present invention was realized in：A kind of bionics skin, the bionics skin is being urged by basic reaction thing, auxiliary agent and water
The catalytic action of agent issues raw emulsion polymerization formation cross-linked structure and forms；It is total that wherein described basic reaction thing accounts for reactant
The 10-20% of quality, the auxiliary agent accounts for the 40-55% of reactant gross mass, and remaining is water；The basic reaction thing includes 47-60
The polydimethylsiloxane of part ethenyl blocking, the poly- silica of the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based
Alkane；The catalyst is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；The auxiliary agent includes reducing product
The thinner of sticky sense, the emulsifying agent for increasing product emulsifying degree, the wetting agent for increasing skin surface humidity, regulation product soda acid
The pH adjusting agent of degree, the thickening agent for increasing product viscosity, the spreading agent and enhancing product dispersibility that improve product extravagance performance
With the refiner for improving aesthetic effect；The thinner includes polydimethylsiloxane and trisiloxanes, polydimethylsiloxane
In one or two；The emulsifying agent includes polydimethylsiloxane/PEG-10/15 cross linked polymers and the silicon of decamethyl ring five
One or two in oxygen alkane, diisobutyl PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymers；The wetting agent includes benzene
Oxyethanol, pentanediol and Flos Magnoliae glycol 1:One or more in 1 diol mixture, Propylene Glycol, butanediol, glycerol；It is described
PH adjusting agent is sodium hydroxide；The thickening agent includes acrylate/C10-30 alkyl acrylate cross-linked polymers, decamethyl
D5 and polydimethylsiloxanepolymer polymer, polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes, chlorine
Change one or more in sodium；The spreading agent is ring five dimethyl silicone polymer；The refiner is three isostearic acid isopropyls
The nylon 12 of oxygen titanium salt modification.A kind of artificial skin is prepared by above-mentioned material.Artificial skin bone is formed by basic reaction thing
Frame, by adding auxiliary agent the performance of artificial skin is changed.
The artificial skin that this programme is provided is safe and reliable, and existing documents and materials are recorded and show that what patent of the present invention was related to matches somebody with somebody
Fang Chengfen possesses safety and biocompatibility, causes without sensitization scorching.
It is pointed out that " polydimethylsiloxane and the trisiloxanes " mentioned in this programme refers to a kind of material, and
It is not " polydimethylsiloxane " and " trisiloxanes " bi-material.Equally, polydimethylsiloxane/PEG-10/15 crosslinkings are poly-
Compound and decamethylcyclopentaandoxane, decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer, polydimethylsiloxane
Cross-linked copolymer and ring pentamethyl siloxanes similarly distinguish a kind of material of acute pyogenic infection of finger tip.
The present invention further technical scheme be：The polydimethylsiloxane of the ethenyl blocking is Andisil companies
The mixture of VS200 products and VS10 products；The polysiloxanes containing active hydrogen-based are Andisil companies XL-11 products；Institute
Karstedt platinum catalysts are stated for AB Specialty Silicones Products；The polydimethylsiloxane and three silica
Alkane is Dow Corning Corporation companies PMX-1184 products；The polydimethylsiloxane is Dow Corning
Corporation companies PMX-200 products；The polydimethylsiloxane/PEG-10/15 cross linked polymers and decamethyl ring five
Siloxanes is Shin-Etsu Chemical Corporation companies KSG-240 products；The diisobutyl PEG/PPG-10/
7/ polydimethylsiloxanecopolymer copolymer is Dow Corning Corporation companies FZ-2233 products；Acrylate/C10-
30 alkyl acrylate cross-linked polymers are Lubrizol Corporation companies Pemulen TR-2 products and Ultrez 20
The mixture of product；The decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer are Dow Corning
Corporation companies DC9045 products；The polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes are Dow
Corning Corporation companies DC9040 products；The ring five dimethyl silicone polymer is Dow Corning
Corporation companies PMX-0245 products and Shin-Etsu Chemical Corporation companies KF-995 products it is mixed
Compound；The nylon 12 of the three isostearic acids isopropyl oxygen titanium salt modification is Kobo Products companies Nylon10-12 products.
It should be noted that same Chinese chemistry name may correspond to two kinds of different concrete products under claiming in this programme
In product, such as this programme " polydimethylsiloxane of ethenyl blocking " used respectively Andisil companies VS200 products and
VS10 products, both products are all the polydimethylsiloxane of ethenyl blocking, but contents of ethylene is different, therefore are had
Different viscosity, the property of the artificial skin that can be provided this programme is impacted.
Another object of the present invention is to provide a kind of preparation method of bionics skin.
The method is comprised the following steps,
Step A：Prepare the first reactant liquor；First reactant liquor includes mixed uniformly basic reaction thing, water and auxiliary agent；Wherein
The basic reaction thing accounts for the 25-36% of the first reactant liquor gross mass, and the auxiliary agent accounts for the 15-25% of the first reactant liquor gross mass,
Remaining is water；The basic reaction thing includes polydimethylsiloxane, the vapor phase method of 20-29 parts of 47-60 part ethenyl blockings
The polysiloxanes of white carbon and 17-36 parts containing active hydrogen-based；
Step B：Prepare the second reactant liquor；Second reactant liquor includes mixed uniformly catalyst, water and auxiliary agent；Wherein it is catalyzed
Agent quality accounts for the 0.5-3% of the second reactant liquor gross mass, and the auxiliary agent accounts for the 60-80% of the second reactant liquor gross mass,
Remaining is water；The catalyst is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；
Step C：First reactant liquor is applied on skin；
Step D：Second reactant liquor is applied in step C on the region for having smeared first reactant liquor, reaction is formed
Artificial skin；1-2 times that smears that quality is first reactant liquor of second reactant liquor.
The present invention further technical scheme be：Step A include it is following step by step,
Step A1：Prepare primary response solution；The primary response solution by basic reaction thing, reduce the sticky sense of product thinner and
Obtain after the uniform mixing of emulsifying agent for increasing product emulsifying degree；Include 7-10 part Andisil in the basic reaction thing
The products of polydimethylsiloxane VS 200 of company's ethenyl blocking, the poly- diformazan of 40-50 part Andisil companies ethenyl blocking
The polysiloxanes of the products of radical siloxane VS 10, the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based；
Step A2：Prepare dilute solution：The dilute solution is uniform by thickening agent, the wetting agent of increase skin surface humidity and water
Obtain after mixing；
Step A3：Prepare the first reactant liquor；The dilute solution is added slowly to the primary response by the first reactant liquor system
Formed to formation white milk cream shape emulsion in solution.
The present invention further technical scheme be：Step A also includes A4 step by step：Add pH adjusting agent and adjust institute
It is 5.5-6.6 to state the first reactant liquor to pH value.This programme can be adjusted by the sodium hydroxide solution that concentration is 10N to pH value
Section.
The present invention further technical scheme be：Step B include it is following step by step,
Step B1：Prepare thickening solution, the thickening solution is by increasing the thickening agent of product viscosity, improve product extravagance performance
The emulsifying agent of spreading agent and increase product emulsifying degree is formed after uniformly mixing；
Step B2：Wetting solution is prepared, the wetting solution is made up of the wetting agent of water and increase skin surface humidity；
Step B3:Prepare the second reactant liquor；It is molten that the wetting solution is slowly dropped to the thickening by the second reactant liquor system
In liquid to formed add after limpid emulsion catalyst obtain.
The present invention further technical scheme be：Add in step B3 and add before the catalyst 3-7 parts to strengthen
The refiner of product dispersibility and raising aesthetic effect；The refiner is the nylon of three isostearic acid isopropyl oxygen titanium salts modification.
The present invention further technical scheme be：The thinner is poly- including Dow Corning Corporation companies
Dimethyl siloxane and trisiloxanes PMX-1184 product 10-14 parts, Dow Corning Corporation companies poly dimethyl
Siloxanes PMX-200 product 1-5 parts；The emulsifying agent includes the poly- diformazan of Shin-Etsu Chemical Corporation companies
Radical siloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane KSG-240 product 3-7 parts, Dow Corning
Corporation companies diisobutyl PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymer FZ-2233 product 0.05-0.3
Part；The thickening agent includes Lubrizol Corporation companies acrylate/C10-30 alkyl acrylate cross-linked polymerics
Thing Pemulen TR-2 product 0.1-0.7 parts, Lubrizol Corporation companies acrylate/C10-30 alkyl acrylics
The product 0.1-0.7 parts of ester cross linked polymer Ultrez 20, the wetting agent includes phenoxyethanol 0.1-0.5 parts, pentanediol and pungent
Ethylene glycol 1:1 diol mixture 0.1-0.5 parts.
The present invention further technical scheme be：The thickening agent includes Dow Corning Corporation companies ten
Methyl D5 and polydimethylsiloxanepolymer polymer DC9045 product 8-13 parts, Dow Corning Corporation
Company's polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes DC9040 product 1-3 parts, Sodium Chloride 0.3-0.7 part；
The spreading agent includes Shin-Etsu Chemical Corporation companies ring five dimethyl silicone polymer KF-995 product
13-18 parts, Dow Corning Corporation companies ring five dimethyl silicone polymer PMX-0245 product 0.1-3 parts；It is described
Wetting agent includes phenoxyethanol 0.1-0.7 parts, pentanediol and Flos Magnoliae glycol 1:1 diol mixture 3-7 parts, Propylene Glycol 8-13
Part, butanediol 8-13 parts, glycerol 3-8 parts；The emulsifying agent is poly- including Shin-Etsu Chemical Corporation companies
Dimethyl siloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane KSG-240 product 2-7 parts, Dow
Corning Corporation companies diisobutyl PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymer FZ-2233 products
0.1-0.3 parts.
The invention has the beneficial effects as follows：The first reactant liquor can smear the second reactant liquor with skin tight adhesion in this programme
Afterwards polysiloxane ingredient is cross-linking in the presence of platinum catalyst forms firm network structure, the biomimetic cosmetic for courishing skin of formation
Washable waterproof, the biomechanical property for possessing normal skin only needs directly to tear during removal, convenient and safe, prepares quick.
This programme possesses following advantage:1) existing documents and materials are recorded and show that the formula components that patent of the present invention is related to possess safety
And biocompatibility, cause without sensitization scorching;2) viscosity is suitable, easy to apply uniform in skin surface, easy film forming；3) biomechanical property
It is good, such as stretch moduluses, adhesiveness, contractility；4）Air permeable humidity retaining excellent performance, washable waterproof can stop extraneous harmful factor
Infringement；5）Bionics skin surface prepared by patented method of the present invention smooths and thickness is only 75 microns, the Nylon10-12 of addition
Possess good optical effect, bionics skin and human skin's perfect adaptation can be made, without significantly connection boundary line.Using this
Bionics skin prepared by inventive method is applied to after human body skin that skin smooth, high resilience can be made, and mitigates wrinkle.
Specific embodiment
Present invention firstly provides a kind of bionics skin, the bionics skin is by basic reaction thing, auxiliary agent and water in catalysis
The catalytic action of agent issues raw emulsion polymerization formation cross-linked structure and forms；Wherein described basic reaction thing accounts for the total matter of reactant
The 10-20% of amount, the auxiliary agent accounts for the 40-55% of reactant gross mass, and remaining is water；The basic reaction thing includes 47-60 parts
The polydimethylsiloxane of ethenyl blocking, the poly- silica of the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based
Alkane；The catalyst is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；The auxiliary agent includes reducing product
The thinner of sticky sense, the emulsifying agent for increasing product emulsifying degree, the wetting agent for increasing skin surface humidity, regulation product soda acid
The pH adjusting agent of degree, the thickening agent for increasing product viscosity, the spreading agent and enhancing product dispersibility that improve product extravagance performance
With the refiner for improving aesthetic effect；The thinner includes polydimethylsiloxane and trisiloxanes, polydimethylsiloxane
In one or two；The emulsifying agent includes polydimethylsiloxane/PEG-10/15 cross linked polymers and the silicon of decamethyl ring five
One or two in oxygen alkane, diisobutyl PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymers；The wetting agent includes benzene
Oxyethanol, pentanediol and Flos Magnoliae glycol 1:One or more in 1 diol mixture, Propylene Glycol, butanediol, glycerol；It is described
PH adjusting agent is sodium hydroxide；The thickening agent includes acrylate/C10-30 alkyl acrylate cross-linked polymers, decamethyl
D5 and polydimethylsiloxanepolymer polymer, polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes, chlorine
Change one or more in sodium；The spreading agent is ring five dimethyl silicone polymer；The refiner is three isostearic acid isopropyls
The nylon 12 of oxygen titanium salt modification.
A kind of artificial skin is prepared by above-mentioned material.Artificial skin skeleton is formed by basic reaction thing, by adding
Auxiliary agent changes the performance of artificial skin.
The artificial skin that this programme is provided is safe and reliable, and existing documents and materials are recorded and show that what patent of the present invention was related to matches somebody with somebody
Fang Chengfen possesses safety and biocompatibility, causes without sensitization scorching.
It is pointed out that " polydimethylsiloxane and the trisiloxanes " mentioned in this programme refers to a kind of material, and
It is not " polydimethylsiloxane " and " trisiloxanes " bi-material.Equally, polydimethylsiloxane/PEG-10/15 crosslinkings are poly-
Compound and decamethylcyclopentaandoxane, decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer, polydimethylsiloxane
Cross-linked copolymer and ring pentamethyl siloxanes similarly distinguish a kind of material of acute pyogenic infection of finger tip.
Further, the polydimethylsiloxane of the ethenyl blocking is that Andisil companies VS200 products and VS10 are produced
The mixture of product；The polysiloxanes containing active hydrogen-based are Andisil companies XL-11 products；The Karstedt platinum catalysis
Agent is AB Specialty Silicones Products；The polydimethylsiloxane and trisiloxanes are Dow Corning
Corporation companies PMX-1184 products；The polydimethylsiloxane is Dow Corning Corporation companies
PMX-200 products；The polydimethylsiloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane are Shin-
Etsu Chemical Corporation companies KSG-240 products；The diisobutyl PEG/PPG-10/7/ poly dimethyl silicon
Siloxane copolymers are Dow Corning Corporation companies FZ-2233 products；Acrylate/C10-30 alkyl acrylics
Ester cross linked polymer is the mixing of Lubrizol Corporation companies Pemulen TR-2 products and the products of Ultrez 20
Thing；The decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer are Dow Corning Corporation companies
DC9045 products；The polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes are Dow Corning
Corporation companies DC9040 products；The ring five dimethyl silicone polymer is Dow Corning Corporation companies
The mixture of PMX-0245 products and Shin-Etsu Chemical Corporation companies KF-995 products；Described three is different hard
The nylon 12 of fat acid isopropyl oxygen titanium salt modification is Kobo Products companies Nylon10-12 products.
The invention also discloses a kind of manufacture method of bionics skin.
The method is comprised the following steps,
Step A：Prepare the first reactant liquor；First reactant liquor includes mixed uniformly basic reaction thing, water and auxiliary agent；Wherein
The basic reaction thing accounts for the 25-36% of the first reactant liquor gross mass, and the auxiliary agent accounts for the 15-25% of the first reactant liquor gross mass,
Remaining is water；The basic reaction thing includes polydimethylsiloxane, the vapor phase method of 20-29 parts of 47-60 part ethenyl blockings
The polysiloxanes of white carbon and 17-36 parts containing active hydrogen-based；
Step A include it is following step by step,
Step A1：Prepare primary response solution；The primary response solution by basic reaction thing, reduce the sticky sense of product thinner and
Obtain after the uniform mixing of emulsifying agent for increasing product emulsifying degree；Include 7-10 part Andisil in the basic reaction thing
The products of polydimethylsiloxane VS 200 of company's ethenyl blocking, the poly- diformazan of 40-50 part Andisil companies ethenyl blocking
The polysiloxanes of the products of radical siloxane VS 10, the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based；
Step A2：Prepare dilute solution：The dilute solution is uniform by thickening agent, the wetting agent of increase skin surface humidity and water
Obtain after mixing；
Step A3：Prepare the first reactant liquor；The dilute solution is added slowly to the primary response by the first reactant liquor system
Formed to formation white milk cream shape emulsion in solution.
Step A4：It is 5.5-6.6 to add pH adjusting agent and adjust first reactant liquor to pH value.This programme can pass through
Concentration is adjusted for the sodium hydroxide solution of 10N to pH value.
Wherein, the thinner includes Dow Corning Corporation company's polydimethylsiloxane and three silica
Alkane PMX-1184 product 10-14 parts, Dow Corning Corporation companies polydimethylsiloxane PMX-200 product 1-5
Part；The emulsifying agent includes that Shin-Etsu Chemical Corporation companies polydimethylsiloxane/PEG-10/15 is handed over
Linked polymer and decamethylcyclopentaandoxane KSG-240 product 3-7 parts, the isobutyl of Dow Corning Corporation companies two
Base PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymer FZ-2233 product 0.05-0.3 parts；The thickening agent includes
Lubrizol Corporation companies acrylate/C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2 products
0.1-0.7 parts, Lubrizol Corporation companies acrylate/C10-30 alkyl acrylate cross-linked polymer Ultrez
20 product 0.1-0.7 parts, the wetting agent includes phenoxyethanol 0.1-0.5 parts, pentanediol and Flos Magnoliae glycol 1:1 glycol mixing
Thing 0.1-0.5 parts
Step B：Prepare the second reactant liquor；Second reactant liquor includes mixed uniformly catalyst, water and auxiliary agent；Wherein it is catalyzed
Agent quality accounts for the 0.5-3% of the second reactant liquor gross mass, and the auxiliary agent accounts for the 60-80% of the second reactant liquor gross mass,
Remaining is water；The catalyst is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；
Step B include it is following step by step,
Step B1：Prepare thickening solution, the thickening solution is by increasing the thickening agent of product viscosity, improve product extravagance performance
The emulsifying agent of spreading agent and increase product emulsifying degree is formed after uniformly mixing；
Step B2：Wetting solution is prepared, the wetting solution is made up of the wetting agent of water and increase skin surface humidity；
Step B3:Prepare the second reactant liquor；It is molten that the wetting solution is slowly dropped to the thickening by the second reactant liquor system
In liquid to formed add after limpid emulsion catalyst obtain.
Add in step B3 and add before the catalyst 3-7 parts to strengthen product dispersibility and improve aesthetic effect
Refiner；The refiner is the nylon of three isostearic acid isopropyl oxygen titanium salts modification.
The thickening agent includes Dow Corning Corporation company's decamethylcyclopentaandoxanes and poly dimethyl silicon
Oxygen alkane polymer DC9045 product 8-13 parts, Dow Corning Corporation companies polydimethylsiloxane copolymerzation with cross-linking
Thing and ring pentamethyl siloxanes DC9040 product 1-3 parts, Sodium Chloride 0.3-0.7 part；The spreading agent includes Shin-Etsu
Chemical Corporation companies ring five dimethyl silicone polymer KF-995 product 13-18 parts, Dow Corning
Corporation companies ring five dimethyl silicone polymer PMX-0245 product 0.1-3 parts；The wetting agent includes phenoxyethanol
0.1-0.7 parts, pentanediol and Flos Magnoliae glycol 1:1 diol mixture 3-7 parts, Propylene Glycol 8-13 part, butanediol 8-13 parts, glycerol
3-8 parts；The emulsifying agent includes Shin-Etsu Chemical Corporation companies polydimethylsiloxane/PEG-10/
15 cross linked polymers and decamethylcyclopentaandoxane KSG-240 product 2-7 parts, Dow Corning Corporation companies two
Isobutyl group PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymer FZ-2233 product 0.1-0.3 parts.
Step C：First reactant liquor is applied on skin；
Step D：Second reactant liquor is applied in step C on the region for having smeared first reactant liquor, reaction is formed
Artificial skin；1-2 times that smears that quality is first reactant liquor of second reactant liquor.
The specific embodiment for preparing artificial skin according to the method described above is given below.
Specific embodiment 1：
1. emulsion 1
A. in blender 1, by 31.0% basic reaction thing, 12.0%PMX-1184 (polydimethylsiloxane and three silica
Alkane), 2.0% PMX-200 (polydimethylsiloxane), 5.0%KSG-240（Polydimethylsiloxane/PEG-10/15 cross-linked polymerics
Thing and decamethylcyclopentaandoxane）、0.1%FZ-2233（Diisobutyl PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymers）
Mix homogeneously.
Wherein have 25% in basic reaction thing for fume colloidal silica, fume colloidal silica can strengthen the mechanical tenacity of product
And viscosity.Polydimethylsiloxane (Andisil, VS 200) comprising 11.0% ethenyl blocking in remaining 75% mass,
The polydimethylsiloxane (Andisil, VS10) of 60.0% ethenyl blocking and 29.0% polysiloxanes containing active hydrogen-based
(Andisil, XL-11)。
B. in blender 2, by 48.4% water, 0.4%Pemulen TR-2（Acrylate/C10-30 alkyl acrylates
Cross linked polymer）、0.4%Ultrez 20（Acrylate/C10-30 alkyl acrylate cross-linked polymers）, 0.2% benzene oxygen second
Alcohol, 0.3% diol mixture (pentanediol and Flos Magnoliae glycol, 1:1) mix homogeneously.
C. the mixture that b step is obtained is added slowly in the mixture of a steps acquisition, until forming white milk cream shape
Emulsion, adds 0.2%10N sodium hydroxide solutions, adjusts its pH value to 5.5-6.5.
2. emulsion 2
D. in blender 3, by 10.0% DC9045（Decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer）、2.0%
DC9040（Polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes）、5.0%KSG-240（Polydimethylsiloxane/
PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane）、 0.2%FZ-2233（Diisobutyl PEG/PPG-10/7/ poly- two
Methylpolysiloxane Copolymer）, 15.0%KF-995 (ring five dimethyl silicone polymer), the 1.0%PMX-0245 (poly dimethyls of ring five
Siloxanes), 0.5% Sodium Chloride, 5.0% glycerol mix homogeneously.
E. in blender 4, by 30.0% water, 0.3% phenoxyethanol, 5.0% diol mixture (pentanediol and Flos Magnoliae glycol,
1:1), 10.0% Propylene Glycol, 10.0% butanediol mix homogeneously.
F. the mixture that step e is obtained is slowly dropped into into the mixture of Step d acquisition until forming limpid emulsion, then will
5.0%Nylon10-12 is slowly added to mix homogeneously in the emulsion, finally adds 1.0% Karstedt platinum catalyst solutions and (contains
2.0% platinum) and mix homogeneously.
The usage ratio of emulsion 1 and emulsion 2 is 2 when using:3, emulsion 1 is first smeared, repaste and smear emulsion 2, emulsion 1 can be with skin
Skin tight adhesion, smears polysiloxane ingredient firm network structure of cross-linking formation in the presence of platinum catalyst after emulsion 2,
The washable waterproof of biomimetic cosmetic for courishing skin of formation, possesses the biomechanical property of normal skin.Only need to tear during removal.
The mechanical property of the artificial skin obtained through detection, this specific embodiment is as follows.
Stretch moduluses are 0.45MPa, and breaking strain is 800%, and adhesion strength is 78N mm-1。
Stretching experiment shows that stretch moduluses of the normal skin under 40% strain are 0.5-1.95MPa, patented method of the present invention
The biomimetic cosmetic for courishing skin of preparation when stretch moduluses are 0.5 MPa breaking strain up to 240%.So this programme offer is artificial
Skin has elasticity well.
Biomimetic cosmetic for courishing skin prepared by patented method of the present invention is applied to after forearm 24h, the skin retraction time is compared
26.7% is reduced using front（Using it is front and using it is rear be respectively 750ms, 550ms）.Illustrate that skin elasticity is significantly improved.
Percutaneous water loss（TEWL）Detection test display, biomimetic cosmetic for courishing skin application prepared by patented method of the present invention
TEWL declines 20% after 24h（Using it is front and using after 24h be respectively 4.0g/m2h、3.2g/m2h）.Illustrate the people that this programme is provided
Making skin can effectively keep moisture of skin, it is to avoid water loss.
In sum, the artificial skin that this programme is provided possesses following advantage:1) existing documents and materials are recorded and show this
The formula components that patent of invention is related to possess safety and biocompatibility, cause without sensitization scorching;2) viscosity is suitable, in skin surface
It is easy to apply uniform, easy film forming；3) biomechanical property is good, such as stretch moduluses, adhesiveness, contractility；4）Air permeable humidity retaining performance
Good, washable waterproof can stop the infringement of extraneous harmful factor；5）Bionics skin surface prepared by patented method of the present invention it is smooth and
Thickness is only 75 microns, and the Nylon10-12 of addition possesses good optical effect, can make bionics skin and human skin
Perfect adaptation, without significantly connection boundary line.The bionics skin prepared using the inventive method is applied to after human body skin that skin can be made
Skin is smooth, high resilience, mitigates wrinkle.
Presently preferred embodiments of the present invention is the foregoing is only, not to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of bionics skin, it is characterised in that：The bionics skin by basic reaction thing, auxiliary agent and water catalyst catalysis
Effect issues raw emulsion polymerization formation cross-linked structure and forms；Wherein described basic reaction thing accounts for the 10- of reactant gross mass
20%, the auxiliary agent accounts for the 40-55% of reactant gross mass, and remaining is water；The basic reaction thing is sealed including 47-60 parts vinyl
The polydimethylsiloxane at end, the polysiloxanes of the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based；It is described to urge
Agent is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；The auxiliary agent includes reducing the sticky sense of product
Thinner, the emulsifying agent for increasing product emulsifying degree, the wetting agent for increasing skin surface humidity, the pH of regulation product acid-base value are adjusted
Section agent, the thickening agent for increasing product viscosity, the spreading agent and enhancing product dispersibility that improve product extravagance performance and raising are beautiful
Learn the refiner of effect；The thinner includes the one kind in polydimethylsiloxane and trisiloxanes, polydimethylsiloxane
Or two kinds；The emulsifying agent include polydimethylsiloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane, two
One or two in isobutyl group PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymers；The wetting agent include phenoxyethanol,
Pentanediol and Flos Magnoliae glycol 1:One or more in 1 diol mixture, Propylene Glycol, butanediol, glycerol；The pH adjusting agent
For sodium hydroxide；The thickening agent includes acrylate/C10-30 alkyl acrylate cross-linked polymers, the silica of decamethyl ring five
In alkane and polydimethylsiloxanepolymer polymer, polydimethylsiloxane cross-linked copolymer and ring pentamethyl siloxanes, Sodium Chloride
One or more；The spreading agent is ring five dimethyl silicone polymer；The refiner is repaiied for three isostearic acid isopropyl oxygen titanium salts
The nylon 12 of decorations.
2. bionics skin according to claim 1, it is characterised in that the polydimethylsiloxane of the ethenyl blocking is
The mixture of Andisil companies VS200 products and VS10 products；The polysiloxanes containing active hydrogen-based are Andisil companies
XL-11 products；The Karstedt platinum catalysts are AB Specialty Silicones Products；The poly dimethyl silicon
Oxygen alkane and trisiloxanes are Dow Corning Corporation companies PMX-1184 products；The polydimethylsiloxane is
Dow Corning Corporation companies PMX-200 products；The polydimethylsiloxane/PEG-10/15 cross linked polymers
It is Shin-Etsu Chemical Corporation companies KSG-240 products with decamethylcyclopentaandoxane；Two isobutyl
Base PEG/PPG-10/7/ polydimethylsiloxanecopolymer copolymers are Dow Corning Corporation companies FZ-2233 products；
Acrylate/C10-30 alkyl acrylate cross-linked polymers are that Lubrizol Corporation companies Pemulen TR-2 are produced
The mixture of product and the products of Ultrez 20；The decamethylcyclopentaandoxane and polydimethylsiloxanepolymer polymer are Dow
Corning Corporation companies DC9045 products；The polydimethylsiloxane cross-linked copolymer and ring pentamethyl silica
Alkane is Dow Corning Corporation companies DC9040 products；The ring five dimethyl silicone polymer is Dow Corning
Corporation companies PMX-0245 products and Shin-Etsu Chemical Corporation companies KF-995 products it is mixed
Compound；The nylon 12 of the three isostearic acids isopropyl oxygen titanium salt modification is Kobo Products companies Nylon10-12 products.
3. a kind of preparation method of bionics skin, it is characterised in that comprise the following steps,
Step A：Prepare the first reactant liquor；First reactant liquor includes mixed uniformly basic reaction thing, water and auxiliary agent；Wherein
The basic reaction thing accounts for the 25-36% of the first reactant liquor gross mass, and the auxiliary agent accounts for the 15-25% of the first reactant liquor gross mass,
Remaining is water；The basic reaction thing includes polydimethylsiloxane, the vapor phase method of 20-29 parts of 47-60 part ethenyl blockings
The polysiloxanes of white carbon and 17-36 parts containing active hydrogen-based；
Step B：Prepare the second reactant liquor；Second reactant liquor includes mixed uniformly catalyst, water and auxiliary agent；Wherein urge
Agent quality accounts for the 0.5-3% of the second reactant liquor gross mass, and the auxiliary agent accounts for the 60- of the second reactant liquor gross mass
80%, remaining is water；The catalyst is Karstedt platinum catalysts, and the platinum containing amount of the catalyst is 1-5%；
Step C：First reactant liquor is applied on skin；
Step D：Second reactant liquor is applied in step C on the region for having smeared first reactant liquor, reaction is formed
Artificial skin；1-2 times that smears that quality is first reactant liquor of second reactant liquor.
4. the preparation method of bionics skin according to claim 3, it is characterised in that：Step A includes following substep
Suddenly,
Step A1：Prepare primary response solution；The primary response solution by basic reaction thing, reduce the sticky sense of product thinner and
Obtain after the uniform mixing of emulsifying agent for increasing product emulsifying degree；Include 7-10 part Andisil in the basic reaction thing
The products of polydimethylsiloxane VS 200 of company's ethenyl blocking, the poly- diformazan of 40-50 part Andisil companies ethenyl blocking
The polysiloxanes of the products of radical siloxane VS 10, the fume colloidal silica of 20-29 parts and 17-36 parts containing active hydrogen-based；
Step A2：Prepare dilute solution：The dilute solution is uniform by thickening agent, the wetting agent of increase skin surface humidity and water
Obtain after mixing；
Step A3：Prepare the first reactant liquor；The dilute solution is added slowly to the primary response by the first reactant liquor system
Formed to formation white milk cream shape emulsion in solution.
5. the preparation method of bionics skin according to claim 4, it is characterised in that：Step A is also included step by step
A4：It is 5.5-6.6 to add pH adjusting agent and adjust first reactant liquor to pH value.
6. according to the preparation method of arbitrary described bionics skin in claim 3-5, it is characterised in that：Step B includes
Below step by step,
Step B1：Prepare thickening solution, the thickening solution is by increasing the thickening agent of product viscosity, improve product extravagance performance
The emulsifying agent of spreading agent and increase product emulsifying degree is formed after uniformly mixing；
Step B2：Wetting solution is prepared, the wetting solution is made up of the wetting agent of water and increase skin surface humidity；
Step B3:Prepare the second reactant liquor；It is molten that the wetting solution is slowly dropped to the thickening by the second reactant liquor system
In liquid to formed add after limpid emulsion catalyst obtain.
7. the preparation method of bionics skin according to claim 6, it is characterised in that：Urge described in adding in step B3
3-7 parts are added to strengthen product dispersibility and improve the refiner of aesthetic effect before agent；The refiner is three isostearic acids
The nylon of isopropyl oxygen titanium salt modification.
8. the preparation method of bionics skin according to claim 4, it is characterised in that：The thinner includes Dow
Corning Corporation company's polydimethylsiloxane and trisiloxanes PMX-1184 product 10-14 parts, Dow
Corning Corporation companies polydimethylsiloxane PMX-200 product 1-5 parts；The emulsifying agent includes Shin-Etsu
Chemical Corporation companies polydimethylsiloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane
KSG-240 product 3-7 parts, Dow Corning Corporation companies diisobutyl PEG/PPG-10/7/ polydimethylsiloxanes
Alkyl copolymer FZ-2233 product 0.05-0.3 parts；The thickening agent include Lubrizol Corporation companies acrylate/
C10-30 alkyl acrylate cross-linked polymer Pemulen TR-2 product 0.1-0.7 parts, Lubrizol Corporation are public
Department's product 0.1-0.7 parts of acrylate/C10-30 alkyl acrylate cross-linked polymers Ultrez 20, the wetting agent includes
Phenoxyethanol 0.1-0.5 parts, pentanediol and Flos Magnoliae glycol 1:1 diol mixture 0.1-0.5 parts.
9. the preparation method of bionics skin according to claim 6, it is characterised in that：The thickening agent includes Dow
Corning Corporation company's decamethylcyclopentaandoxanes and polydimethylsiloxanepolymer polymer DC9045 product 8-13
Part, Dow Corning Corporation company's polydimethylsiloxane cross-linked copolymers and ring pentamethyl siloxanes DC9040
Product 1-3 parts, Sodium Chloride 0.3-0.7 part；The spreading agent includes Shin-Etsu Chemical Corporation companies ring
Five polydimethylsiloxane KF-995 product 13-18 parts, the polydimethylsiloxanes of Dow Corning Corporation companies ring five
Alkane PMX-0245 product 0.1-3 parts；The wetting agent includes phenoxyethanol 0.1-0.7 parts, pentanediol and Flos Magnoliae glycol 1:The two of 1
Alcohol mixture 3-7 parts, Propylene Glycol 8-13 part, butanediol 8-13 parts, glycerol 3-8 parts；The emulsifying agent includes Shin-Etsu
Chemical Corporation companies polydimethylsiloxane/PEG-10/15 cross linked polymers and decamethylcyclopentaandoxane
KSG-240 product 2-7 parts, Dow Corning Corporation companies diisobutyl PEG/PPG-10/7/ polydimethylsiloxanes
Alkyl copolymer FZ-2233 product 0.1-0.3 parts.
Priority Applications (2)
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|---|---|---|---|
| CN201611167553.1A CN106668937A (en) | 2016-12-16 | 2016-12-16 | Bionic skin and preparation method thereof |
| PCT/CN2017/100138 WO2018107821A1 (en) | 2016-12-16 | 2017-09-01 | Bionic skin and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611167553.1A CN106668937A (en) | 2016-12-16 | 2016-12-16 | Bionic skin and preparation method thereof |
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| Publication Number | Publication Date |
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ID=58869651
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611167553.1A Pending CN106668937A (en) | 2016-12-16 | 2016-12-16 | Bionic skin and preparation method thereof |
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| WO (1) | WO2018107821A1 (en) |
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| WO2018107821A1 (en) * | 2016-12-16 | 2018-06-21 | 深圳市茵冠生物科技有限公司 | Bionic skin and preparation method therefor |
| CN108524330A (en) * | 2018-06-04 | 2018-09-14 | 上海其鸿新材料科技有限公司 | A kind of one-component coating fluid and preparation method thereof of the stealthy skin of elasticity |
| CN108567997A (en) * | 2018-06-04 | 2018-09-25 | 上海其鸿新材料科技有限公司 | A kind of high strength elastic stealth artificial skin |
| CN109966176A (en) * | 2017-12-28 | 2019-07-05 | 伊丽英 | A kind of skin wrinkle composition and its application |
| CN110559212A (en) * | 2019-10-14 | 2019-12-13 | 南京医科大学 | Polysiloxane moisturizing and wrinkle removing mask and using method thereof |
| CN113740491A (en) * | 2021-08-27 | 2021-12-03 | 无限极（中国）有限公司 | Simulated skin for sensory evaluation and preparation method thereof |
| CN114010539A (en) * | 2021-10-29 | 2022-02-08 | 华中科技大学 | Bionic polymer film for beauty treatment and preparation method and application thereof |
| CN114846188A (en) * | 2019-12-23 | 2022-08-02 | 花王株式会社 | Method for producing colored nonwoven fabric |
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| CN115243733A (en) * | 2020-03-17 | 2022-10-25 | 株式会社资生堂 | Composition for forming artificial skin and method of using the same |
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| CN113740491A (en) * | 2021-08-27 | 2021-12-03 | 无限极（中国）有限公司 | Simulated skin for sensory evaluation and preparation method thereof |
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Application publication date: 20170517 |
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| RJ01 | Rejection of invention patent application after publication |