CN113712845A - Anti-aging repairing lithospermum composition and application thereof in skin care products - Google Patents
Anti-aging repairing lithospermum composition and application thereof in skin care products Download PDFInfo
- Publication number
- CN113712845A CN113712845A CN202111124780.7A CN202111124780A CN113712845A CN 113712845 A CN113712845 A CN 113712845A CN 202111124780 A CN202111124780 A CN 202111124780A CN 113712845 A CN113712845 A CN 113712845A
- Authority
- CN
- China
- Prior art keywords
- lithospermum
- aging
- repairing
- composition
- palmitoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001071917 Lithospermum Species 0.000 title claims abstract description 94
- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 80
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 55
- 229920001184 polypeptide Polymers 0.000 claims abstract description 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 241001107116 Castanospermum australe Species 0.000 claims abstract description 24
- 229940069765 bean extract Drugs 0.000 claims abstract description 24
- 235000021279 black bean Nutrition 0.000 claims abstract description 24
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- WSGCRSMLXFHGRM-DEVHWETNSA-N (2s)-2-[[(2s)-6-amino-2-[[(2s,3r)-2-[[(2s,3r)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]amino]-3-hydroxypropanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O WSGCRSMLXFHGRM-DEVHWETNSA-N 0.000 claims abstract description 13
- BYUQATUKPXLFLZ-UIOOFZCWSA-N CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(O)=O)CC1=CN=CN1 BYUQATUKPXLFLZ-UIOOFZCWSA-N 0.000 claims abstract description 13
- 229940093441 palmitoyl oligopeptide Drugs 0.000 claims abstract description 13
- OGNHOGPWQTWKGQ-VGWMRTNUSA-N (2S)-5-amino-2-[[(2S)-1-[2-[[(2S)-5-amino-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N1[C@H](C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 OGNHOGPWQTWKGQ-VGWMRTNUSA-N 0.000 claims abstract description 12
- IHRKJQSLKLYWBQ-QKDODKLFSA-N (2s)-2-[[(2s)-1-[(2s)-5-amino-2-[[2-(hexadecanoylamino)acetyl]amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O IHRKJQSLKLYWBQ-QKDODKLFSA-N 0.000 claims abstract description 12
- LODWEXDBRZBADB-XEVVZDEMSA-N (2s)-6-amino-2-[[(2s)-2-[[(2s)-6-amino-2-(hexadecanoylamino)hexanoyl]amino]-3-methylbutanoyl]amino]hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(O)=O LODWEXDBRZBADB-XEVVZDEMSA-N 0.000 claims abstract description 12
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 12
- 229940094946 palmitoyl tetrapeptide-7 Drugs 0.000 claims abstract description 12
- 229940094912 palmitoyl tripeptide-5 Drugs 0.000 claims abstract description 12
- 238000013329 compounding Methods 0.000 claims abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 30
- 239000003906 humectant Substances 0.000 claims description 28
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 20
- 239000006071 cream Substances 0.000 claims description 20
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 claims description 18
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 18
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 17
- 239000002131 composite material Substances 0.000 claims description 17
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 17
- 102000016359 Fibronectins Human genes 0.000 claims description 16
- 108010067306 Fibronectins Proteins 0.000 claims description 16
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 16
- 239000000686 essence Substances 0.000 claims description 16
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 16
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 16
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 15
- 229960000458 allantoin Drugs 0.000 claims description 15
- 239000003974 emollient agent Substances 0.000 claims description 15
- 229920001577 copolymer Polymers 0.000 claims description 14
- 239000003995 emulsifying agent Substances 0.000 claims description 14
- 239000012752 auxiliary agent Substances 0.000 claims description 13
- 239000004475 Arginine Substances 0.000 claims description 11
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 11
- -1 polyethylene Polymers 0.000 claims description 10
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 claims description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 9
- 239000004202 carbamide Substances 0.000 claims description 9
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 claims description 9
- 229960004063 propylene glycol Drugs 0.000 claims description 9
- 239000005720 sucrose Substances 0.000 claims description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 8
- 229960003237 betaine Drugs 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229940078492 ppg-17 Drugs 0.000 claims description 8
- 239000002738 chelating agent Substances 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 5
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 5
- 241000221095 Simmondsia Species 0.000 claims description 5
- 235000004433 Simmondsia californica Nutrition 0.000 claims description 5
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 5
- 230000003750 conditioning effect Effects 0.000 claims description 5
- 229940086555 cyclomethicone Drugs 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 229940119170 jojoba wax Drugs 0.000 claims description 5
- 229940041616 menthol Drugs 0.000 claims description 5
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 5
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 5
- 239000010452 phosphate Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- 229960004793 sucrose Drugs 0.000 claims description 5
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 5
- 229940045136 urea Drugs 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- ORUDEUCNYHCHPB-OUUBHVDSSA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-tetradecoxyoxane-3,4,5-triol Chemical compound CCCCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ORUDEUCNYHCHPB-OUUBHVDSSA-N 0.000 claims description 4
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 4
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 4
- 241001442052 Symphytum Species 0.000 claims description 4
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 claims description 4
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 239000004200 microcrystalline wax Substances 0.000 claims description 4
- 235000019808 microcrystalline wax Nutrition 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 239000006210 lotion Substances 0.000 claims description 2
- 235000005865 Symphytum officinale Nutrition 0.000 claims 3
- 230000003716 rejuvenation Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 31
- 230000037303 wrinkles Effects 0.000 abstract description 27
- 208000002874 Acne Vulgaris Diseases 0.000 abstract description 20
- 206010000496 acne Diseases 0.000 abstract description 20
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 abstract description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract description 2
- 239000000905 isomalt Substances 0.000 abstract description 2
- 235000010439 isomalt Nutrition 0.000 abstract description 2
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 abstract description 2
- 239000000787 lecithin Substances 0.000 abstract description 2
- 235000010445 lecithin Nutrition 0.000 abstract description 2
- 229940067606 lecithin Drugs 0.000 abstract description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract description 2
- 235000010234 sodium benzoate Nutrition 0.000 abstract description 2
- 239000004299 sodium benzoate Substances 0.000 abstract description 2
- 229940038226 comfrey root extract Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 79
- 210000004027 cell Anatomy 0.000 description 27
- 238000003756 stirring Methods 0.000 description 22
- 238000012360 testing method Methods 0.000 description 19
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 17
- 102000008186 Collagen Human genes 0.000 description 15
- 108010035532 Collagen Proteins 0.000 description 15
- 229920001436 collagen Polymers 0.000 description 15
- 230000001804 emulsifying effect Effects 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 230000009467 reduction Effects 0.000 description 12
- 230000008439 repair process Effects 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 11
- 238000001816 cooling Methods 0.000 description 10
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 239000003755 preservative agent Substances 0.000 description 7
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 6
- 229960001631 carbomer Drugs 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 230000002335 preservative effect Effects 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000001815 facial effect Effects 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 4
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 4
- 230000032683 aging Effects 0.000 description 4
- 229960003993 chlorphenesin Drugs 0.000 description 4
- 229960005323 phenoxyethanol Drugs 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 230000008591 skin barrier function Effects 0.000 description 4
- 210000000434 stratum corneum Anatomy 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 3
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 229940047670 sodium acrylate Drugs 0.000 description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 description 2
- 241000130781 Arnebia Species 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 229940087291 tridecyl alcohol Drugs 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 description 1
- VMZJCIQOZYJFRB-UHFFFAOYSA-N 3-iodoprop-1-yn-1-ol Chemical compound OC#CCI VMZJCIQOZYJFRB-UHFFFAOYSA-N 0.000 description 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 241000130784 Arnebia euchroma Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- NEZONWMXZKDMKF-UHFFFAOYSA-N C.I. Natural Red 20 Chemical group C1=CC(O)=C2C(=O)C(C(O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 240000004035 Lithospermum officinale Species 0.000 description 1
- 235000011030 Lithospermum officinale Nutrition 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 102000004183 Synaptosomal-Associated Protein 25 Human genes 0.000 description 1
- 108010057722 Synaptosomal-Associated Protein 25 Proteins 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 206010048245 Yellow skin Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- SKKTUOZKZKCGTB-UHFFFAOYSA-N butyl carbamate Chemical compound CCCCOC(N)=O SKKTUOZKZKCGTB-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 230000035618 desquamation Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000001723 extracellular space Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000011120 smear test Methods 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000037331 wrinkle reduction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an anti-aging repairing lithospermum composition and application thereof in skin care products. The anti-aging and repairing lithospermum composition is prepared by compounding 0.02-0.7 part of compound polypeptide, 0.003-5.0 parts of lithospermum cell mixture, 0.002-2.0 parts of black bean extract and 0-2.6 parts of other conditioners, wherein the compound polypeptide is two or more of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl pentapeptide-4, and the lithospermum cell mixture is prepared by compounding 93% of isomalt, 0.8% of comfrey root extract, 0.8% of lecithin, 0.3% of sodium benzoate and 5.1% of water in percentage by mass. The anti-aging repairing lithospermum composition can effectively reduce acne marks and wrinkles and has an excellent effect of repairing skin.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an anti-aging repairing lithospermum composition and application thereof in skin care products.
Background
The city life with fast pace and high intensity brings intangible pressure and challenge while creating comfort and convenience for people. Factors such as air pollution, working pressure, seasonal changes, etc. constantly challenge the fragile skin of urban people. Common symptoms include dryness, desquamation, pox, collagen loss and rupture, wrinkles, sagging, sensitive skin, red blood streaks, post-sun repair and post-cosmetic skin damage, with the ultimate manifestation of fine lines and the onset of aging.
In order to enable 'problem skin' to have the functions of repairing cell activity, increasing skin compactness and enabling the skin to present a full outline, polypeptide is added into a plurality of skin care products at present. The polypeptide is much milder than the factors of vitamin A and vitrescence, basically has no side effect, does not need to establish tolerance, and can be used for sensitive muscle. Intact, non-fragmented proteins (e.g. collagen) are not absorbed through the epidermal layer of the skin, and polypeptides are essentially small fragments or basic components of proteins, and compared with intact proteins, part of polypeptides can break through the skin barrier and be absorbed by the skin, so that the polypeptide has a certain effect of relieving skin aging injury.
There are many types of polypeptides, each with its own specific repair mechanism. For example, pentapeptide can stimulate collagen, spandex and hyaluronic acid proliferation, increase skin thickness and reduce fine lines. The hexapeptide is involved in competing SNAP-25 sites in the vacuolar complex, influences the formation of the vacuolar complex, and if the vacuolar complex is slightly unstable, the vacuolar complex can not effectively release neurotransmitters, so that the muscle contraction is weakened, and the formation of wrinkles is prevented. If different polypeptides can be compounded, the skin can be repaired in multiple directions, and the synergistic effect is achieved.
However, in practice, it is found that polypeptides cannot be simply mixed and compounded, and the skin repairing effect is reduced after the polypeptides are compounded. Because the variety and the addition amount of the polypeptide and the compounded components in the skin care product relate to thousands of combined experiments, enterprises cannot verify the effect brought by the composite polypeptide through limited tests. Because of this, the number of polypeptide-complexed products currently on the market is small, and further research and improvement is needed.
Disclosure of Invention
In order to provide a synergistic composite polypeptide, the application provides an anti-aging repairing lithospermum composition and application thereof in skin care products.
In a first aspect, the application provides an anti-aging and repairing lithospermum composition, which is prepared from the following components in parts by mass:
0.02-0.7 part of composite polypeptide;
0.003-5.0 parts of lithospermum cell mixture;
0.002-2.0 parts of black bean extract;
0-2.6 parts of other conditioning agents;
the composite polypeptide is two or more of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl pentapeptide-4.
Tripeptide-1 is carrier peptide and has biological activities of antioxidation, integration detoxification and the like; hexapeptide-9 is a very stable collagen peptide, and has an excellent effect on potent repair, particularly for the repair of acne marks; the palmitoyl tripeptide-5 can improve the moisture content of skin, improve the skin color and enhance the luster and the transparency; palmitoyl tripeptide-1 stimulates the synthesis of collagen and glycosaminoglycan, reduces fine lines of skin and improves skin quality. The palmitoyl pentapeptide-4 can greatly promote the generation of skin collagen, make the facial skin plump and elastic, improve the water content and moisture retention of the skin, make the skin feel soft and smooth, and brighten the skin color from inside to outside without tarnish; palmitoyl tetrapeptide-7 can stimulate proliferation of elastic fibers and hyaluronic acid, improve moisture content and moisture locking degree of the skin, increase thickness of the skin and reduce fine lines, can enhance absorption effect, can increase hyaluronic acid content in the skin by acting as a cell messenger to stimulate regeneration of collagen fibers in the dermis, and can help tighten the skin by drawing moisture to the epidermis.
The polypeptide can act on the skin from different aspects so as to achieve the aim of repairing dry skin, acne marks, dark yellow skin, fine lines, wrinkles and other skin problems. If the polypeptide can be fully fused, the application field of the polypeptide is changed technically. Through continuous research of the inventor, the inventor finds that different kinds of polypeptides can be well fused together under the synergistic addition effect of the lithospermum cell mixture and the black bean extract by mixing the lithospermum cell mixture, the black bean extract and the composite polypeptide according to the proportion. In addition, the lithospermum cell mixture and the black bean extract can effectively eliminate and eliminate free radicals, reduce aging, accelerate blood circulation, expand capillary vessels and promote absorption and transformation of polypeptides. Meanwhile, the collagen can be combined with protein, so that healthy collagen is protected from being damaged, new collagen regeneration is promoted, acne marks and wrinkles are effectively reduced, and the collagen has an excellent effect of repairing skin.
More preferably, the complex polypeptide consists of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tetrapeptide-7 in a ratio of 1: (1.3-2): (0.3-1): (0.7-1): (1-1.3): (3-4.3) in a certain mass ratio.
The proportion of the polypeptides is a subject to be researched all the time, and a scheme for compounding more than five polypeptides is not researched at present. The main reason is that the selection of the types of the polypeptides is unclear whether the polypeptides can be compounded to achieve a synergistic effect, the types of the related polypeptides are multiple, and the existing enterprises are difficult to verify that experiments are conducted on each mixture ratio, which is a very practical problem. The application adopts the six polypeptides and matches the above proportions, so that the effect of repairing the skin of the anti-aging repairing lithospermum composition is broken through, and acne marks and wrinkles are further reduced.
Preferably, the rest conditioning agent is 0.002-0.1 parts of fibronectin.
Since fibronectin is a macromolecular protein, skin has poor absorption of the macromolecular protein, and direct use of fibronectin can only play a minor role in repair. However, in the anti-aging and repairing lithospermum composition system, the compound polypeptide, the lithospermum cell mixture and the black bean extract are matched, so that the sodium potassium ATPase beta subunit on the surface of the skin can be activated, the beta subunit is used for regulating gaps among skin cells in the skin, and the cell gap is slightly enlarged, and the degree is enough to guide fibrin to migrate to a basal layer through a skin barrier, promote cell growth and proliferation, and play an important role in the body life activities such as repairing and tissue regeneration of the skin.
Preferably, the remaining conditioning agents are fibronectin, arginine and allantoin in a ratio of 1: (2-10): (1-8) in a certain mass ratio.
After the compound polypeptide, the lithospermum cell mixture and the black bean extract enter the skin for repairing, metabolic cuticle is generated. In order to further assist the skin to absorb fibronectin, arginine and allantoin are selected and the proportion of the arginine and the allantoin is limited, so that the skin care cream has obvious effects on keeping skin moisture, improving skin roughness, improving the water content of stratum corneum and the like, reduces the adhesive force of stratum corneum cells, accelerates the renewal of epidermal cells, timely cleans generated wastes, and enables the fibronectin entering from the back to be better absorbed, thereby further helping the skin repair and reducing wrinkles.
In a second aspect, the application provides an application of the anti-aging repairing lithospermum composition in skin care products, wherein the addition amount of the anti-aging repairing lithospermum composition in the skin care products is 0.2-15%; wherein the addition amount in skin care water is 1-13%, the addition amount in essence is 3-15%, the addition amount in lotion and cream is 1-14%, and the addition amount in eye cream is 0.2-14%.
In a third aspect, the application provides an anti-aging and repairing lithospermum essence which is prepared from the following components in percentage by mass:
21-33.5% of a humectant;
0.01 to 0.1 percent of emulsifier;
3-15% of anti-aging repairing lithospermum composition;
0-1.7% of other auxiliary agents;
adding water to 100%;
the humectant is any two of glycerol, butanediol, 1, 2-hexanediol, sodium hyaluronate, propylene glycol, urea and sucrose.
The other auxiliary agents are preservative, chelating agent and antioxidant. The preservative system is built by methyl hydroxybenzoate, octyl hydroximic acid, bis (hydroxymethyl) imidazolidinyl urea and iodopropynyl alcohol butyl carbamate.
Because the anti-aging repairing lithospermum composition contains a plurality of polypeptides and plant extracts with a plurality of active ingredients, the anti-aging repairing lithospermum composition is compounded with the rest ingredients to form essence liquid, and the addition proportion needs to be controlled, because the anti-aging repairing lithospermum composition has high cost of the used ingredients, and the problem of cost is considered in industrial production, and the anti-aging repairing lithospermum composition with a small amount can also play a good repairing effect, which is a place needing further improvement.
The components in the essence are added in the proportion, the anti-aging repairing lithospermum composition can exert a better repairing effect under the condition of adding 3-11%, the moisturizing agent can assist the anti-aging repairing lithospermum composition in repairing skin, and other auxiliaries have no negative influence on the activity of the anti-aging repairing lithospermum composition, so that the prepared anti-aging repairing lithospermum composition is good in repairing effect and low in cost.
More preferably, the humectant is any three of glycerin, butanediol, 1, 2-hexanediol, sodium hyaluronate, propylene glycol, urea and sucrose.
Most preferably, the humectant is prepared by compounding glycerol, butanediol, 1, 2-hexanediol, sodium hyaluronate, propylene glycol, sucrose and urea, wherein the compounding ratio is 100: (70-72): (6-8): (2-3): (3-5): (2-4): (4-5).
The moisture loss is increased during skin aging, cells are shrunk and aged, tissues are lack and atrophy, and the tissues are changed in structure and form to gradually form fine wrinkles on the skin, so that the moisturizing agent plays an important role in keeping the moisture of the skin and repairing the barrier function of the skin. The moisturizing agent is added into an anti-aging repairing lithospermum essence system according to a specific proportion, so that a skin barrier is in a relatively soft state, the skin keeps a good capability of cleaning cutin, and metabolites of the anti-aging repairing lithospermum composition after repairing the skin can be better cleaned by the skin, so that the repairing speed is increased, and wrinkles, acne marks and the like are reduced more in the same time.
In a fourth aspect, the application provides an anti-aging and repairing lithospermum eye cream which is prepared from the following components in percentage by mass:
10-20% of an emollient;
10-15% of a humectant;
5-10% of emulsifier;
0.2-14% of the anti-aging lithospermum rehabilitating composition of any one of claims 1-4;
0.1-0.2% of chelating agent;
0.02-0.05% of pH regulator;
0.8 to 1.5 percent of other auxiliary agents;
adding water to 100%;
the humectant is a compound of butanediol, sodium hyaluronate and betaine;
the emollient is a compound of cyclomethicone, cyclohexasiloxane, jojoba oil and caprylic/capric triglyceride.
In a fifth aspect, the application provides anti-aging and repairing zicao water, which comprises the following components in percentage by mass:
7-15% of a humectant;
5-10% of emulsifier;
1.5-3% of an emollient;
1-13% of the anti-aging lithospermum rehabilitating composition of any one of claims 1-4;
0.1 to 0.2 percent of pH regulator;
0.03-0.06% of menthol PCA ester;
2-3% of other auxiliary agents;
adding water to 100%;
the emollient is a compound of isohexadecane and polyethylene glycol-8.
In a sixth aspect, the application provides an anti-aging lithospermum maintenance cream or cream, which is prepared from the following components in percentage by mass:
10-15% of a humectant;
15-25% of an emollient;
4-6% of an emulsifier;
1-1.5% of emulsion stabilizer;
1-14% of the anti-aging lithospermum restorative composition of any one of claims 1-4;
0.01 to 0.02 percent of pH regulator;
0.5 to 1 percent of other auxiliary agents;
adding water to 100%;
the emollient is a compound of isohexadecane, hydrogenated polyisobutene, isononyl isononanoate, polydimethylsiloxane and jojoba seed oil;
the emulsifier is a compound of PEG/PPG-17/6 copolymer, C20-22 alcohol phosphate and myristyl glucoside.
The emulsion stabilizer is a compound of cetearyl alcohol and microcrystalline wax.
The anti-aging lithospermum repairing composition can stably act in skin care products, effectively reduces acne marks and skin lines, and has an excellent effect of repairing the skin. The skin care cream can be applied to water, milk, cream, eye cream and essence, is not limited to the products, and can also be applied to other skin care products such as body milk, sun screen and the like.
To sum up, under the synergistic addition effect of the lithospermum cell mixture and the black bean extract in the anti-aging repairing lithospermum composition, different kinds of polypeptides can be well fused together, free radicals are effectively eliminated and eliminated, aging can be reduced, blood circulation can be accelerated, capillary vessels can be expanded, absorption and transformation of the polypeptides are promoted, and meanwhile, the anti-aging repairing lithospermum composition can be combined with protein, so that healthy collagen is protected from being damaged, new collagen regeneration is promoted, acne marks and wrinkles are effectively reduced, and an excellent skin repairing effect is achieved.
Detailed Description
Tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4, and palmitoyl tetrapeptide-7 are all purchased from cypress chemical technology, ltd, guangzhou.
The lithospermum cell mixture is purchased from Phytoelectc Symphytum with the product number of 0522 sold by Milbaile company of Switzerland, and the product is compounded by 93 percent of isomalt, 0.8 percent of polymeric grass root extract, 0.8 percent of lecithin, 0.3 percent of sodium benzoate and 5.1 percent of water according to the mass percentage.
Black bean extract was purchased from Zhushidi trade, Inc., Guangzhou.
Polysorbate-20 was purchased from Tween 20 of Bo-Tu chemical technology, Inc., Guangzhou.
Sodium acrylate/sodium acryloyldimethyl taurate copolymer, C20-22 alcohol phosphate, isohexadecane, polysorbate-80 were purchased from Baihabo Co., Ltd, Guangzhou.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer was purchased from Oxxue chemical Co., Ltd, Guangzhou.
Caprylic/capric triglyceride was purchased from Shunhxing commercial Co., Ltd, Guangzhou.
Tridecyl alcohol polyether-6 and sodium polyacrylate were purchased from Zhongbo New materials, Inc., Guangzhou.
Polyethylene glycol-8 was purchased from Chongqing Darunxiang Biotech, Inc.
Menthol PCA ester was purchased from Shanghai lion science development, Inc.
Polydimethylsiloxane, cyclomethicone, was purchased from Guangzhou Andi chemical Co., Ltd.
Jojoba seed oil was purchased from Guangzhou sanderiya Biotechnology GmbH and was sourced from golden jojoba oil, Henry, Germany.
The skin care products include many kinds, which cannot be exhausted. Therefore, the representative five skin care products are selected in the design of the embodiment, but the application of the anti-aging repairing lithospermum composition is not limited to the five products, and the anti-aging repairing lithospermum composition can also be applied to other skin care products.
Examples
Example 1
The embodiment discloses an anti-aging and repairing lithospermum essence which is prepared from the following components:
humectant: 116g of glycerol, 80g of butanediol and 5g of 1, 2-hexanediol.
Anti-aging repairing lithospermum composition: 3.6g of lithospermum cell mixture, 2.4g of black bean extract and composite polypeptide: palmitoyl tripeptide-112 g and palmitoyl pentapeptide-412 g.
Emulsifier: polysorbate-200.12 g.
Water was added to 1000 g.
The preparation method of the anti-aging repairing lithospermum essence comprises the following steps: adding glycerol and butanediol in humectant into emulsifying pot, stirring at 75 deg.C for 20min, and keeping the temperature for 15 min; then, cooling, adding 1, 2-hexanediol in the humectant into the emulsifying pot when the temperature is reduced to 40 ℃, and stirring the palmitoyl tripeptide-1 and the palmitoyl pentapeptide-4 in the anti-aging and repairing lithospermum composition at the rotating speed of 40 r/min; cooling to room temperature after stirring, adding the lithospermum cell mixture and the black bean extract into an emulsifying pot, stirring for 20r/min, and discharging to obtain the anti-aging repairing lithospermum essence.
Example 2
The differences from example 1 are: the composite polypeptide is selected from palmitoyl pentapeptide-412 g and palmitoyl tetrapeptide-712 g.
Adding glycerol and butanediol in humectant and chelating agent in other adjuvants into emulsifying pan, stirring at 85 deg.C, rotating speed of 40min, and keeping the temperature for 30 min; then, cooling, adding 1, 2-hexanediol and sodium hyaluronate in the humectant into an emulsifying pot when the temperature is reduced to 50 ℃, and stirring polypeptides in the anti-aging repairing lithospermum composition at a rotating speed of 50 r/min; adding the preservative, the propylene glycol in the humectant, the sucrose and the urea into an emulsifying pot after stirring uniformly, changing the stirring speed to 65r/min, adding the lithospermum cell mixture and the black bean extract into the emulsifying pot after cooling to room temperature, stirring for 30r/min, and discharging to obtain the anti-aging repair lithospermum essence.
Example 3
The differences from example 2 are: the humectant is selected from 116g of glycerin, 80g of butanediol, 5g of 1,2 hexanediol and 2g of sucrose.
The compound polypeptide is tripeptide-12 g, palmitoyl pentapeptide-410 g and palmitoyl tetrapeptide-712 g.
Example 4
The differences from example 3 are: the humectant is prepared from 116g of glycerin, 80g of butanediol, 5g of 1,2 hexanediol, 1g of sodium hyaluronate and 3g of urea.
Example 5
The differences from example 3 are: the humectant is prepared from 116g of glycerin, 80g of butanediol, 5g of 1,2 hexanediol, 1g of sodium hyaluronate, 3g of propylene glycol, 2g of sucrose and 3g of urea.
The composite polypeptide comprises 1.7g tripeptide-1, 2.5g hexapeptide-9, 1.7g palmitoyl tripeptide-5, 1.7g palmitoyl tripeptide-1, 2.5g palmitoyl pentapeptide-4 and 1.7g palmitoyl tetrapeptide-7.
Example 6
The differences from example 5 are: the humectant is prepared from 160g of glycerin, 120g of butanediol, 15g of 1,2 hexanediol, 8g of sodium hyaluronate, 12g of propylene glycol, 10g of sucrose and 10g of urea.
The composite polypeptide comprises 1.0g tripeptide-1, 1.5g hexapeptide-9, 1.0g palmitoyl tripeptide-5, 1.0g palmitoyl tripeptide-1, 1.5g palmitoyl pentapeptide-4 and 1.0g palmitoyl tetrapeptide-7.
20g of black bean extract and 50g of lithospermum cell mixture.
And (3) the rest auxiliary agents: preservative: 3g of methylparaben, 3g of octanohydroxamic acid, 0.08g of bis (hydroxymethyl) imidazolidinyl urea and 0.08g of iodopropynyl butylcarbamate. Chelating agent: 1.2g disodium EDTA. Antioxidant: 10g of p-hydroxyacetophenone.
To facilitate the data between comparative examples 1 to 6, the input components and the input amounts (g) are collated in Table 1.
TABLE 1
Examples 7 to 10
The difference from example 5 is that the amounts (g) of the components added are different, and the specific table is shown in Table 2.
Example 9 differs from example 5 in that the composite polypeptide consists of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tetrapeptide-7 in a ratio of 1: 1.3: 0.3: 0.7: 1: 3, and the components are compounded according to the mass ratio.
Example 10 differs from example 5 in that the composite polypeptide consists of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tetrapeptide-7 in a ratio of 1: 2: 1: 1: 1.3: 4.3, and the components are compounded according to the mass ratio.
TABLE 2
Example 11
The difference from example 9 is that: also 0.02g fibronectin was present in the anti-aging repairing composition.
Fibronectin was added with propylene glycol with stirring.
Example 12
The difference from example 11 is that: also included in the anti-aging treatment composition was 1.0g fibronectin.
Example 13
The difference from example 12 is that: the anti-aging and repairing arnebia composition also comprises 2.0g of arginine and 1.0g of allantoin.
Adding arginine and 1, 2-hexanediol into an emulsifying pot and stirring.
Allantoin and glycerin are added into an emulsifying pot and stirred.
Example 14
The difference from example 13 is that: the anti-aging and repairing arnebia composition also comprises 10.0g of arginine and 8.0g of allantoin.
Example 15
The embodiment discloses an anti-aging lithospermum repair eye cream which is prepared from the following raw materials:
humectant: 500g of butanediol, 5.0g of sodium hyaluronate and 400g of betaine.
Emulsifier: 40.0g of PEG/PPG-17/6 copolymer, 30.0g of cetearyl alcohol, 50.0g of sodium polyacrylate, 30.0g of C18-21 alkyl and 64.0 g of trideceth-64.0 g.
And (3) an emollient: 315g of cyclomethicone, 385g of cyclohexasiloxane, 500g of jojoba oil and 400g of caprylic/capric triglyceride.
Anti-aging lithospermum repairing composition: 10.3 g of tripeptide-10.3 g, 90.4 g of hexapeptide-10.2 g of palmitoyl tripeptide-50.2 g of palmitoyl tripeptide-70.4 g of palmitoyl tetrapeptide-41.0 g of palmitoyl pentapeptide, 2.0g of lithospermum cell mixture, 8.0g of black bean extract, 0.02g of fibronectin, 1.0g of arginine and 2.0g of allantoin.
Chelating agent: 1.1g of octanoyl hydroximic acid.
pH regulator: 5.0g of potassium hydroxide.
Other auxiliary agents: preservative (p-hydroxyacetophenone 10.0 g), thickener (carbomer 40.0g, acacia gum 3.0g and xanthan gum 1.0 g).
Water was added to 10 Kg.
The preparation method of the anti-aging lithospermum repair eye cream comprises the following steps:
adding water, butanediol, PEG/PPG-17/6 copolymer, betaine, carbomer, p-hydroxyacetophenone, sodium hyaluronate, allantoin, acacia gum and xanthan gum into a water pot, homogenizing for 3min, stirring, heating to 85 deg.C, and keeping the temperature for 10 min. Heating cyclomethicone, cyclohexasiloxane, jojoba oil, caprylic/capric triglyceride and cetearyl caprylhydroxamic acid in emulsifying pot at 85 deg.C, homogenizing for 2min, and keeping the temperature for 10 min. Pumping the materials in the water pot into an emulsifying pot, uniformly stirring, cooling to 50 ℃, adding potassium hydroxide, sodium polyacrylate, C18-21 alkane and tridecyl alcohol polyether-6, uniformly stirring, continuously cooling to 40 ℃, adding the anti-aging lithospermum repairing composition, and uniformly stirring to obtain the anti-aging lithospermum repairing eye cream.
Example 16
The embodiment discloses anti-aging lithospermum repairing water which is prepared from the following raw materials:
humectant: butanediol 0.5Kg, betaine 0.4Kg and 1, 2-hexanediol 0.01 Kg.
Emulsifier: 0.8Kg of PEG/PPG-17/6 copolymer and 800.03 Kg of polysorbate.
And (3) an emollient: 0.09Kg of isohexadecane and 80.1 Kg of polyethylene glycol.
Anti-aging lithospermum repairing composition: tripeptide-13 g, hexapeptide-94 Kg, palmitoyl tripeptide-11.5 g, palmitoyl tripeptide-52 g, palmitoyl tetrapeptide-74 g, palmitoyl pentapeptide-410 g, lithospermum cell mixture 160g, black bean extract 80g, fibronectin 0.2g, arginine 14g and allantoin 16 g.
pH regulator: 10g of sodium hydroxide.
Other auxiliary agents: preservatives (phenoxyethanol 10g, chlorphenesin 8g and methylparaben 10 g) and thickeners (sodium acrylate/sodium acryloyldimethyl taurate copolymer 150g and carbomer 50 g).
5g menthol PCA ester.
Water was added to 10 Kg.
The preparation method of the anti-aging lithospermum repairing water comprises the following steps:
adding water, PEG/PPG-17/6 copolymer, butanediol, betaine, carbomer, sodium hyaluronate, allantoin and methyl hydroxybenzoate into a water kettle, homogenizing for 3min, stirring, heating to 85 deg.C, and keeping the temperature for 10 min. Then cooling to 60 ℃, adding sodium hydroxide, sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane and polysorbate-80, stirring uniformly, then continuing cooling to 40 ℃, adding the anti-aging lithospermum repairing composition, phenoxyethanol, chlorphenesin, 1, 2-hexanediol and menthol PCA ester, and stirring uniformly to obtain the anti-aging lithospermum repairing water.
Example 17
The embodiment discloses an anti-aging lithospermum maintenance cream which is prepared from the following raw materials:
humectant: butanediol 0.1Kg, betaine 0.3Kg, 1, 2-hexanediol 0.01Kg, and sodium hyaluronate 0.01 Kg.
And (3) an emollient: 0.6Kg of isohexadecane, 0.4Kg of hydrogenated polyisobutene, 0.4Kg of isononyl isononanoate, 0.3Kg of polydimethylsiloxane and 0.1Kg of jojoba seed oil.
Emulsifier: PEG/PPG-17/6 copolymer 0.3Kg, C20-22 alcohol phosphate ester 0.16Kg, and myristyl glucoside 0.05 Kg.
Emulsion stabilizer: cetearyl alcohol 0.08Kg and microcrystalline wax 0.05 Kg.
Anti-aging lithospermum repairing composition: 11 g of tripeptide-11 g, 92g of hexapeptide-92 g, 10.5 g of palmitoyl tripeptide-50.8 g, 71.2 g of palmitoyl tetrapeptide-44 g, 54.1g of lithospermum cell mixture, 27g of black bean extract, 0.1g of fibronectin, 5g of arginine and 5g of allantoin.
pH regulator: 0.01Kg of sodium hydroxide.
Other auxiliary agents: thickening agent (hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 10g and carbomer 10 g), preservative (phenoxyethanol 20g and chlorphenesin 10 g), antioxidant (tocopheryl acetate) 20g and essence 5 g.
Water was added to 5 Kg.
The preparation method of the anti-aging lithospermum maintenance cream comprises the following steps:
adding water, butanediol, 1, 2-hexanediol, PEG/PPG-17/6 copolymer, betaine, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, carbomer, sodium hyaluronate and allantoin into a water kettle, homogenizing for 3min, stirring, heating to 85 deg.C, and keeping the temperature for 10 min. Heating isohexadecane, hydrogenated polyisobutene, isononyl isononanoate, polydimethylsiloxane, C20-22 alcohol phosphate, jojoba seed oil, cetearyl alcohol, microcrystalline wax, myristyl glucoside and tocopherol acetate in an emulsifying pot at 85 deg.C, homogenizing for 2min, and holding for 10 min. Pumping the materials in the water pot into an emulsifying pot, uniformly stirring, cooling to 60 ℃, adding sodium hydroxide, uniformly stirring, continuously cooling to 40 ℃, adding the anti-aging lithospermum repairing composition, phenoxyethanol, chlorphenesin and essence, and uniformly stirring to obtain the anti-aging lithospermum repairing emulsion.
Example 18
The embodiment discloses an anti-aging lithospermum repairing cream which is different from the embodiment 17 in that:
anti-aging lithospermum repairing composition: 11 g of tripeptide-11 g, 92g of hexapeptide-92 g, 15g of palmitoyl tripeptide-58 g, 71.2 g of palmitoyl tetrapeptide-44 g, 60g of lithospermum cell mixture, 30g of black bean extract, 0.1g of fibronectin, 6g of arginine and 5g of allantoin.
Water was added to 5 Kg.
Comparative example
Comparative example 1
The differences from example 5 are: equal amount of black bean extract is used to replace the gromwell mixture.
Comparative example 2
The differences from example 5 are: equal amount of arnebia euchroma cell mixture is used instead of black bean extract.
Comparative example 3
The differences from example 5 are: the addition amount of radix Arnebiae cell mixture is 0.02g, and the addition amount of semen Sojae Atricolor extract is 0.01 g.
Comparative example 4
The differences from example 5 are: the addition amount of the lithospermum cell mixture is 55g, and the addition amount of the black bean extract is 25 g.
Test verification
Test 1
Detecting the effect of removing acne marks
1. Test samples: the essences prepared in examples 1 to 18 and comparative examples 1 to 4.
2. Testing an instrument: facial image analyzer VISIA, Canfield, usa.
3. The test principle is as follows: a facial picture was taken using the facial image analyzer VISIA and the image analysis software analyzed the area of the ultraviolet pigmented spots of the skin.
Note: the acne marks have pigmentation on the skin, are detected by VISIA ultraviolet ray stains, are shot by ultraviolet rays with the peak value of 365nm, and objectively reflect the potential pigmentation area under the epidermis so as to reflect the area of the acne marks.
4. Experiment design: 66 volunteers with acne marks are selected, the volunteers are divided into 22 groups, each group comprises 3 volunteers, the volunteers in each group respectively correspond to the essence prepared in the examples 1-18 and the comparative examples 1-4, and the volunteers clean the face in the morning and the evening and then smear test samples on the face (smeared on eyes in the example 15). A facial image analyzer VISIA is adopted to shoot images of the parts of the volunteers before and after 8 weeks of using the test sample, and the images are analyzed to obtain the area of the acne marks on the face, and the area of the acne marks after use is obviously reduced compared with the area before use, which shows that the test sample has the effects of repairing the skin and removing the acne marks.
5. And (3) data analysis:
area of pox mark: taking the average value of the test results of each group of volunteers;
acne mark reduction rate = (S)0-S1）/SO×100%
S0: average of pox area of each group of volunteers before use.
S1: average of pox area per group of volunteers after use.
Test 2
Detecting the effect of repairing wrinkles
1. Testing an instrument: the skin rapid three-dimensional imaging system PRIMOS, Canfield, usa.
2. The test principle is as follows: the digital three-dimensional image of the surface of the tested skin is obtained by testing the position change of the stripe light irradiated on the surface of the skin and the gray values of all image points, and parameters such as wrinkle volume and the like are obtained by analyzing system software.
3. The test method comprises the following steps: 54 volunteers with fine lines and wrinkles on the face were selected and divided into 18 groups of 3, and the volunteers applied the essence prepared in examples 1-14 and comparative examples 1-4 on the face after cleaning the face in the morning and evening each day. A skin rapid three-dimensional imaging system PRIMOS is adopted to shoot images of the back of a volunteer before and after 6 weeks of using a test sample, and the images are analyzed to obtain a wrinkle volume value V, wherein the wrinkle volume after use is remarkably reduced compared with that before use, which shows that the test sample has the effects of repairing the skin and reducing wrinkles.
4. Data processing:
wrinkle volume value V value change rate (%) = (V)0-V1）/VO×100%
VO: v-value of skin before using test sample;
V1: the V value of the skin after use of the test sample. The data for test 1 and test 2 are collated in Table 3.
TABLE 3
| Pox mark repair effect/%) | Wrinkle repair Effect/%) | |
| Example 1 | 16.4 | 15.3 |
| Example 2 | 16.5 | 15.5 |
| Example 3 | 16.8 | 15.8 |
| Example 4 | 16.1 | 15.9 |
| Example 5 | 24.6 | 20.6 |
| Example 6 | 24.9 | 20.8 |
| Example 7 | 25.6 | 21.4 |
| Example 8 | 25.8 | 21.7 |
| Example 9 | 27.8 | 23.6 |
| Example 10 | 27.5 | 23.3 |
| Example 11 | 28 | 23.9 |
| Example 12 | 27.9 | 23.8 |
| Example 13 | 28.4 | 24.3 |
| Example 14 | 28.6 | 24.5 |
| Example 15 | 28.0 | 24.1 |
| Example 16 | 27.6 | 23.7 |
| Example 17 | 27.9 | 23.9 |
| Example 18 | 28.1 | 24.0 |
| Comparative example 1 | 4.4 | 5.3 |
| Comparative example 2 | 5.9 | 3.8 |
| Comparative example 3 | 8.3 | 9.7 |
| Comparative example 4 | 9.6 | 10.6 |
According to the comparison of the data of the comparative examples 1 and 2 and the data of the examples 1 to 4 in the table 3, the area reduction rate and the wrinkle reduction rate of the comparative examples 1 and 2 are far lower than those of the examples 1 to 4, which shows that even though the polypeptides cannot be fused sufficiently, different kinds of polypeptides can be fused together well through the preparation of the anti-aging repairing lithospermum composition and the black bean extract, so that free radicals can be eliminated and eliminated effectively, aging can be reduced, blood circulation can be accelerated, capillary vessels can be expanded, the absorption and transformation of the polypeptides can be promoted, the polypeptides can be combined with proteins, healthy collagen can be protected from being damaged, new collagen regeneration can be promoted, the acne marks and wrinkles can be reduced effectively, and the excellent skin repairing effect can be achieved.
According to the comparison of the data of the examples 1-4 and the examples 5-6 in the table 3, the reduction rate of the acne mark area and the reduction rate of wrinkles of the examples 5 and 6 are far greater than those of the examples 1-4, which shows that more than five kinds of composite polypeptides can be fully fused together to act on the skin under the coordination of the lithospermum cell mixture and the black bean extract, so that the acne mark and wrinkles are effectively reduced, and the skin repairing effect is excellent.
According to the comparison of the data of examples 7 and 8 and comparative examples 3 and 4 in table 3, the reduction rate of the pox printed area and the reduction rate of the wrinkle of the examples 7 and 8 are both far greater than those of the comparative examples 3 and 4, which shows that the skin repairing effect can be very good only within the range of the input amount of the composite polypeptide, and the proportion of the components in the cosmetic also influences the compatibility and is not adjusted randomly.
From the comparison of the data in table 3 between examples 9 and 10 and example 8, the reduction rate of pox print area and the reduction rate of wrinkles in examples 9 and 10 are both greater than in example 8, indicating that the present application uses the composition consisting of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tetrapeptide-7 in a ratio of 1: (1.3-2): (0.3-1): (0.7-1): (1-1.3): (3-4.3) the compound polypeptide compounded according to the mass ratio can break through the skin repairing effect of the anti-aging repairing lithospermum composition, thereby further reducing acne marks and wrinkles.
Comparing the data of examples 11 and 12 and example 9 in table 3, the reduction rate of the pox print area and the reduction rate of the wrinkles of examples 11 and 12 are both greater than that of example 9, which shows that the combination of the composite polypeptide, the lithospermum cell mixture and the black bean extract can activate the sodium potassium atpase beta subunit on the skin surface, the beta subunit can regulate the gaps between skin cells in the skin, and the intercellular space is slightly enlarged enough to guide fibrin to migrate to the basal layer through the skin barrier, promote cell growth and proliferation, and play an important role in body life activities such as skin repair, tissue regeneration and the like.
Comparing the data of examples 13 and 14 with the data of example 12 in table 3, it can be seen that the reduction rate of the pox print area and the reduction rate of wrinkles of examples 13 and 14 are both greater than that of example 12, which illustrates that amino acid and allantoin define the ratio of the three, and have significant effects on maintaining skin moisture, improving skin roughness, increasing the water content of stratum corneum, reducing the adhesion of stratum corneum cells, accelerating the renewal of epidermal cells, and removing the generated "waste" in time, so that the fibronectin entering later can be better absorbed, thereby further helping skin repair and reducing wrinkles.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. An anti-aging and repairing lithospermum composition is characterized in that: the feed is prepared from the following components in parts by mass:
0.02-0.7 part of composite polypeptide;
0.003-5.0 parts of lithospermum cell mixture;
0.002-2.0 parts of black bean extract;
0-2.6 parts of other conditioning agents;
the composite polypeptide is two or more of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and palmitoyl pentapeptide-4.
2. The anti-aging rejuvenating comfrey composition as claimed in claim 1, wherein: the composite polypeptide consists of tripeptide-1, hexapeptide-9, palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl pentapeptide-4 and palmitoyl tetrapeptide-7 in a weight ratio of 1: (1.3-2): (0.3-1): (0.7-1): (1-1.3): (3-4.3) in a certain mass ratio.
3. The anti-aging restorative comfrey composition as claimed in claim 1 or 2, wherein: the rest conditioner is 0.002-0.1 part of fibronectin.
4. The anti-aging restorative comfrey composition as claimed in claim 1 or 2, wherein: the remaining conditioning agents are fibronectin, arginine and allantoin at a ratio of 1: (25-100): (50-80) by mass ratio.
5. The application of the anti-aging lithospermum repairing composition is characterized in that: the addition amount of the anti-aging repairing lithospermum composition in the skin care product is 0.2-15%; wherein the addition amount in skin care water is 1-13%, the addition amount in essence is 3-15%, the addition amount in lotion and cream is 1-14%, and the addition amount in eye cream is 0.2-14%.
6. The anti-aging repairing lithospermum essence is characterized by being prepared from the following components in percentage by mass:
21-33.5% of a humectant;
0.01 to 0.1 percent of emulsifier;
3-15% of the anti-aging repairing lithospermum composition of any one of claims 1-4;
0-1.7% of other auxiliary agents;
adding water to 100%;
the humectant is any two of glycerol, butanediol, 1, 2-hexanediol, sodium hyaluronate, propylene glycol, urea and sucrose.
7. The anti-aging repairing lithospermum essence as claimed in claim 6, which is characterized in that: the humectant is prepared by compounding glycerol, butanediol, 1, 2-hexanediol, sodium hyaluronate, propylene glycol, sucrose and urea, wherein the compounding ratio is 100: (70-72): (6-8): (2-3): (3-5): (2-4): (4-5).
8. The anti-aging lithospermum repairing eye cream is characterized by being prepared from the following components in percentage by mass:
10-20% of an emollient;
10-15% of a humectant;
5-10% of emulsifier;
0.2-14% of the anti-aging lithospermum rehabilitating composition of any one of claims 1-4;
0.1-0.2% of chelating agent;
0.02-0.05% of pH regulator;
0.8 to 1.5 percent of other auxiliary agents;
adding water to 100%;
the humectant is a compound of butanediol, sodium hyaluronate and betaine;
the emollient is a compound of cyclomethicone, cyclohexasiloxane, jojoba oil and caprylic/capric triglyceride.
9. The anti-aging lithospermum repairing water is characterized by being prepared from the following components in percentage by mass:
7-15% of a humectant;
5-10% of emulsifier;
1.5-3% of an emollient;
1-13% of the anti-aging lithospermum rehabilitating composition of any one of claims 1-4;
0.1 to 0.2 percent of pH regulator;
0.03-0.06% of menthol PCA ester;
2-3% of other auxiliary agents;
adding water to 100%;
the emollient is a compound of isohexadecane and polyethylene glycol-8.
10. The anti-aging lithospermum maintenance cream or cream is characterized by being prepared from the following components in percentage by mass:
10-15% of a humectant;
15-25% of an emollient;
4-6% of an emulsifier;
1-1.5% of emulsion stabilizer;
1-14% of the anti-aging lithospermum restorative composition of any one of claims 1-4;
0.01 to 0.02 percent of pH regulator;
0.5 to 1 percent of other auxiliary agents;
adding water to 100%;
the emollient is a compound of isohexadecane, hydrogenated polyisobutene, isononyl isononanoate, polydimethylsiloxane and jojoba seed oil;
the emulsifier is a compound of PEG/PPG-17/6 copolymer, C20-22 alcohol phosphate and myristyl glucoside;
the emulsion stabilizer is a compound of cetearyl alcohol and microcrystalline wax.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111124780.7A CN113712845B (en) | 2021-09-25 | 2021-09-25 | Anti-aging and repairing lithospermum composition and application thereof in skin care products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111124780.7A CN113712845B (en) | 2021-09-25 | 2021-09-25 | Anti-aging and repairing lithospermum composition and application thereof in skin care products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113712845A true CN113712845A (en) | 2021-11-30 |
| CN113712845B CN113712845B (en) | 2023-10-24 |
Family
ID=78684847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111124780.7A Active CN113712845B (en) | 2021-09-25 | 2021-09-25 | Anti-aging and repairing lithospermum composition and application thereof in skin care products |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113712845B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796003A (en) * | 2022-04-22 | 2022-07-29 | 四川肽美生物科技有限公司 | Anti-aging oligopeptide composition suitable for sensitive skin |
| CN115054563A (en) * | 2022-08-05 | 2022-09-16 | 广州安若希医药科技有限公司 | Polypeptide repairing composition and preparation method thereof |
| CN116650382A (en) * | 2023-07-24 | 2023-08-29 | 广州研智化妆品有限公司 | Tripeptide-1 copper-containing anti-aging repair composition and preparation method and application thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105147773A (en) * | 2015-09-21 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of restraining acne and preparation method and application of traditional Chinese medicine composition |
| CN106265264A (en) * | 2016-08-26 | 2017-01-04 | 珀莱雅化妆品股份有限公司 | A kind of acne-removing composition and preparation method thereof |
| CN107106617A (en) * | 2014-10-31 | 2017-08-29 | 利普泰个人股份有限公司 | Include the cosmetics and/or medical composition and its use of product outside the bacterial cell from South Pole Pseudoalteromonas |
| CN109464373A (en) * | 2018-11-20 | 2019-03-15 | 上海悦目化妆品有限公司 | A kind of antiallergic facial treatment mask |
| CN109602632A (en) * | 2019-01-23 | 2019-04-12 | 广州葆妍生物科技有限公司 | A kind of eye cream of the composition containing peptides and preparation method thereof |
| CN110302107A (en) * | 2019-06-14 | 2019-10-08 | 广州市白云莱茵化妆品厂 | A kind of polypeptide complex repairs Essence and preparation method thereof |
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN112043659A (en) * | 2020-09-27 | 2020-12-08 | 广州保龄奇迹化妆品科技有限公司 | Anti-wrinkle repair essence cream |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| CN112402347A (en) * | 2020-12-18 | 2021-02-26 | 东莞市羽馨化妆品有限公司 | Acne-removing repair composition containing fibronectin and preparation method thereof |
-
2021
- 2021-09-25 CN CN202111124780.7A patent/CN113712845B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106617A (en) * | 2014-10-31 | 2017-08-29 | 利普泰个人股份有限公司 | Include the cosmetics and/or medical composition and its use of product outside the bacterial cell from South Pole Pseudoalteromonas |
| CN105147773A (en) * | 2015-09-21 | 2015-12-16 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with effect of restraining acne and preparation method and application of traditional Chinese medicine composition |
| CN106265264A (en) * | 2016-08-26 | 2017-01-04 | 珀莱雅化妆品股份有限公司 | A kind of acne-removing composition and preparation method thereof |
| CN109464373A (en) * | 2018-11-20 | 2019-03-15 | 上海悦目化妆品有限公司 | A kind of antiallergic facial treatment mask |
| CN109602632A (en) * | 2019-01-23 | 2019-04-12 | 广州葆妍生物科技有限公司 | A kind of eye cream of the composition containing peptides and preparation method thereof |
| CN110302107A (en) * | 2019-06-14 | 2019-10-08 | 广州市白云莱茵化妆品厂 | A kind of polypeptide complex repairs Essence and preparation method thereof |
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN112043659A (en) * | 2020-09-27 | 2020-12-08 | 广州保龄奇迹化妆品科技有限公司 | Anti-wrinkle repair essence cream |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| CN112402347A (en) * | 2020-12-18 | 2021-02-26 | 东莞市羽馨化妆品有限公司 | Acne-removing repair composition containing fibronectin and preparation method thereof |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796003A (en) * | 2022-04-22 | 2022-07-29 | 四川肽美生物科技有限公司 | Anti-aging oligopeptide composition suitable for sensitive skin |
| CN115054563A (en) * | 2022-08-05 | 2022-09-16 | 广州安若希医药科技有限公司 | Polypeptide repairing composition and preparation method thereof |
| CN115054563B (en) * | 2022-08-05 | 2023-09-05 | 广州安若希医药科技有限公司 | Polypeptide repairing composition and preparation method thereof |
| CN116650382A (en) * | 2023-07-24 | 2023-08-29 | 广州研智化妆品有限公司 | Tripeptide-1 copper-containing anti-aging repair composition and preparation method and application thereof |
| CN116650382B (en) * | 2023-07-24 | 2023-12-26 | 广州研智化妆品有限公司 | Tripeptide-1 copper-containing anti-aging repair composition and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113712845B (en) | 2023-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113712845A (en) | Anti-aging repairing lithospermum composition and application thereof in skin care products | |
| CN104546516A (en) | Preparation process and application of compound ceramide liposome | |
| CN113648235B (en) | Composition for immediately removing wrinkles, eye mask essence, wrinkle-removing cosmetic and application | |
| CN110664644B (en) | Skin care composition containing folic acid, essence and preparation method thereof | |
| CN109125194B (en) | Air cushion foundation with blue light resisting effect and preparation method thereof | |
| CN113332227A (en) | Soothing and repairing composition and application thereof in cosmetics | |
| CN112716814A (en) | Double-layer shaking essence and preparation method thereof | |
| CN110742831A (en) | Brightening eye brightening and night-out eye mask essence and preparation method thereof | |
| CN110721148A (en) | Multidirectional pulling and tightening polypeptide essence and preparation method thereof | |
| CN112545955A (en) | Anti-aging repair composition and preparation method and application thereof | |
| CN114588061A (en) | Anti-aging and wrinkle-removing composition, preparation method thereof and skin care product | |
| CN113143830A (en) | Eye cream containing anti-aging composition and preparation method thereof | |
| CN112773761A (en) | Cosmetic composition, essence and preparation method thereof | |
| CN110934772A (en) | Wrinkle-removing and anti-aging composition and application thereof in cosmetics | |
| CN111588650A (en) | Repairing composition, repairing mask liquid and repairing mask | |
| CN114288201B (en) | Composition for removing pouch and fading black eye, and preparation method and application thereof | |
| CN114159333B (en) | Myobase liquid and preparation method thereof | |
| CN115414293A (en) | Anti-aging composition and application thereof | |
| CN113749967B (en) | Peptide composition and application thereof | |
| CN115887322A (en) | Essence capable of whitening, removing freckles, smoothing skin and preserving moisture and preparation method thereof | |
| CN115400066A (en) | Repair anti-wrinkle essence and preparation method thereof | |
| CN113576994A (en) | Composition with synergistic moisturizing and relieving effects, cosmetic and preparation method thereof | |
| US9040097B2 (en) | Compositions for improving skin appearance | |
| CN109010113B (en) | Composition for repairing sensitive skin and application thereof | |
| CN112957271A (en) | Polypeptide composition for quickly removing wrinkles and resisting aging |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |