CN113710670A - 治疗多发性骨髓瘤的方法 - Google Patents

治疗多发性骨髓瘤的方法 Download PDF

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Publication number
CN113710670A
CN113710670A CN202080030185.4A CN202080030185A CN113710670A CN 113710670 A CN113710670 A CN 113710670A CN 202080030185 A CN202080030185 A CN 202080030185A CN 113710670 A CN113710670 A CN 113710670A
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CN
China
Prior art keywords
subject
compound
multiple myeloma
pharmaceutical composition
treating
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Pending
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CN202080030185.4A
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English (en)
Chinese (zh)
Inventor
M·L·威特尔
曹良弦
A·博洛姆斯基
H·路德维希
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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Publication of CN113710670A publication Critical patent/CN113710670A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080030185.4A 2019-02-28 2020-02-26 治疗多发性骨髓瘤的方法 Pending CN113710670A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962812002P 2019-02-28 2019-02-28
US62/812,002 2019-02-28
PCT/US2020/019884 WO2020176610A1 (en) 2019-02-28 2020-02-26 Method for treating a multiple myeloma

Publications (1)

Publication Number Publication Date
CN113710670A true CN113710670A (zh) 2021-11-26

Family

ID=72238680

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080030185.4A Pending CN113710670A (zh) 2019-02-28 2020-02-26 治疗多发性骨髓瘤的方法

Country Status (11)

Country Link
US (1) US20220143016A1 (enExample)
EP (1) EP3931196A4 (enExample)
JP (1) JP2022521801A (enExample)
CN (1) CN113710670A (enExample)
AU (1) AU2020227748A1 (enExample)
BR (1) BR112021016747A2 (enExample)
CA (1) CA3131249A1 (enExample)
EA (1) EA202192117A1 (enExample)
IL (1) IL285800A (enExample)
MX (1) MX2021010398A (enExample)
WO (1) WO2020176610A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978055A (en) * 1973-09-20 1976-08-31 Delalande S.A. Arylamino pyrimidinic derivatives
WO2002047690A1 (en) * 2000-12-12 2002-06-20 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN104918919A (zh) * 2012-11-21 2015-09-16 Ptc医疗公司 取代的反向嘧啶Bmi-1抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2624818B1 (en) * 2010-10-05 2017-04-05 Fresenius Kabi USA, LLC Bortezomib formulations stabilised with boric acid
MX370588B (es) * 2013-08-30 2019-12-16 Ptc Therapeutics Inc Inhibidores de la bmi-1 de pirimidina sustituida.
JP2021535198A (ja) * 2018-08-17 2021-12-16 ピーティーシー セラピューティクス， インコーポレイテッド 膵臓癌を治療する方法
KR20210151061A (ko) * 2019-03-11 2021-12-13 피티씨 테라퓨틱스, 인크. 향상된 생체이용률을 갖는 화합물 형태 및 이의 제형

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978055A (en) * 1973-09-20 1976-08-31 Delalande S.A. Arylamino pyrimidinic derivatives
WO2002047690A1 (en) * 2000-12-12 2002-06-20 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN104918919A (zh) * 2012-11-21 2015-09-16 Ptc医疗公司 取代的反向嘧啶Bmi-1抑制剂

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARNOLD BOLOMSKY等: "Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment", 《JOURNAL OF HEMATOLOGY & ONCOLOGY》, pages 1 - 13 *
余传隆 等: "《中国临床药物大辞典 化学药卷》", vol. 1, 31 August 2018, 中国医药科技出版社, pages: 861 - 862 *
徐志巧 等: "《实用肿瘤临床药物手册》", vol. 1, 30 June 2013, 中国医药科技出版社, pages: 127 - 128 *

Also Published As

Publication number Publication date
US20220143016A1 (en) 2022-05-12
WO2020176610A1 (en) 2020-09-03
EP3931196A4 (en) 2022-12-14
AU2020227748A1 (en) 2021-09-16
MX2021010398A (es) 2022-01-18
EA202192117A1 (ru) 2021-11-23
CA3131249A1 (en) 2020-09-03
EP3931196A1 (en) 2022-01-05
JP2022521801A (ja) 2022-04-12
WO2020176610A8 (en) 2021-08-12
IL285800A (en) 2021-10-31
BR112021016747A2 (pt) 2021-10-19

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