CN113683613A - 一种多环吡啶肟基化合物及其药物组合物和用途 - Google Patents
一种多环吡啶肟基化合物及其药物组合物和用途 Download PDFInfo
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- CN113683613A CN113683613A CN202111051674.0A CN202111051674A CN113683613A CN 113683613 A CN113683613 A CN 113683613A CN 202111051674 A CN202111051674 A CN 202111051674A CN 113683613 A CN113683613 A CN 113683613A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 给药量 | 病毒基因表达倍数 |
对照组 | --- | 9817 |
巴洛沙韦酯组 | 30mg/kg | 2424 |
DSC2706组 | 30mg/kg | 1960 |
DSC2721组 | 30mg/kg | 1901 |
DSC2723组 | 30mg/kg | 2001 |
Claims (7)
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Application Number | Priority Date | Filing Date | Title |
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CN202010934784 | 2020-09-08 | ||
CN2020109347840 | 2020-09-08 |
Publications (2)
Publication Number | Publication Date |
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CN113683613A true CN113683613A (zh) | 2021-11-23 |
CN113683613B CN113683613B (zh) | 2023-06-09 |
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CN202111051674.0A Active CN113683613B (zh) | 2020-09-08 | 2021-09-08 | 一种多环吡啶肟基化合物及其药物组合物和用途 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107709321A (zh) * | 2015-04-28 | 2018-02-16 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
CN110300753A (zh) * | 2018-01-22 | 2019-10-01 | 太景生物科技股份有限公司 | 帽依赖性核酸内切酶抑制剂 |
WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
CN111217810A (zh) * | 2018-11-23 | 2020-06-02 | 维清生物科技(上海)有限公司 | 一种氮杂环二酮化合物及其制备方法 |
CN111253391A (zh) * | 2018-11-30 | 2020-06-09 | 维清生物科技(上海)有限公司 | 一种含氘氮杂环二酮化合物用于治疗流感 |
CN111303147A (zh) * | 2018-12-12 | 2020-06-19 | 银杏树药业(苏州)有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
-
2021
- 2021-09-08 CN CN202111051674.0A patent/CN113683613B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107709321A (zh) * | 2015-04-28 | 2018-02-16 | 盐野义制药株式会社 | 经取代的多环性吡啶酮衍生物及其前药 |
CN110300753A (zh) * | 2018-01-22 | 2019-10-01 | 太景生物科技股份有限公司 | 帽依赖性核酸内切酶抑制剂 |
WO2020015669A1 (zh) * | 2018-07-17 | 2020-01-23 | 南京明德新药研发有限公司 | 抗流感病毒三并环衍生物 |
CN111217810A (zh) * | 2018-11-23 | 2020-06-02 | 维清生物科技(上海)有限公司 | 一种氮杂环二酮化合物及其制备方法 |
CN111253391A (zh) * | 2018-11-30 | 2020-06-09 | 维清生物科技(上海)有限公司 | 一种含氘氮杂环二酮化合物用于治疗流感 |
CN111303147A (zh) * | 2018-12-12 | 2020-06-19 | 银杏树药业(苏州)有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
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