CN113599459A

CN113599459A - Stomach medicine and preparation method thereof

Info

Publication number: CN113599459A
Application number: CN202111101419.2A
Authority: CN
Inventors: 冯学品
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-09-18
Filing date: 2021-09-18
Publication date: 2021-11-05

Abstract

The invention discloses a stomach medicine and a preparation method thereof, wherein the stomach medicine consists of Indian iphigenia bulb, common bletilla pseudobulb, clove, dried orange peel, lily, radix pseudostellariae, hawthorn, Chinese yam and tuckahoe; the traditional Chinese medicine with homology of medicine and food is selected without side effect, and is scientifically extracted and refined by using a modern process, so that the natural structures of bioactive substances and various nutritional ingredients in the traditional Chinese medicine are retained to the maximum extent, and the problems of denaturation and loss of active ingredients of the traditional Chinese medicine, reduction of pharmacological activity and the like are effectively avoided; the medicine has good compatibility effect, high cure rate for various gastritis, no relapse after healing and good clinical effect.

Description

Stomach medicine and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a stomach medicine and a preparation method thereof.

Background

According to the world health management alliance, worldwide patients with gastric diseases have increased from 1.5 million in 1985 to 5 million in 2012, and are expected to reach 7 million by 2025. The staff become people with high incidence of stomach illness due to high living pressure and irregular diet, wherein the prevalence rate of stomach illness of teachers, reporters, drivers and other groups is as high as 90%. Modern medicine mainly treats stomach diseases by promoting gastric motility, helping digestion, inhibiting acid, resisting infection and the like in a symptomatic way, and no specific treatment means exists. At present, a lot of medicines for treating the stomach illness exist, western medicines are multi-purpose antibiotics, but the medicines can only relieve the symptoms, the stomach illness cannot be cured radically, the relapse is easy after the medicine is stopped, and the cure rate is extremely low; although the traditional Chinese medicine has better curative effect than western medicine and higher cure rate, the traditional Chinese medicine is prepared by compounding a plurality of traditional Chinese medicines at present, not only the medicine is complex in compounding, but also the curative effects are uneven, the functions are different, the cure rate of the comprehensive stomach illness is low, and the traditional Chinese medicine has no obvious curative effect on erosive gastritis and atrophic gastritis.

Disclosure of Invention

The present invention aims at providing a stomach medicine and a preparation method thereof, which aims at solving the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a stomach medicine comprises the following components: edible tulip, rhizoma bletillae, clove, dried orange peel, lily, radix pseudostellariae, hawthorn, yam and poria cocos.

Preferably, the stomach medicine comprises the following raw materials in parts by weight: 8-12 parts of edible tulip, 7-13 parts of rhizoma bletillae, 8-12 parts of clove, 13-17 parts of dried orange peel, 14-16 parts of lily, 13-17 parts of radix pseudostellariae, 9-11 parts of hawthorn, 7-13 parts of Chinese yam and 8-12 parts of poria cocos.

Preferably, the stomach medicine comprises the following raw materials in parts by weight: 10 parts of edible tulip, 10 parts of rhizoma bletillae, 10 parts of clove, 15 parts of dried orange peel, 15 parts of lily, 15 parts of radix pseudostellariae, 10 parts of hawthorn, 10 parts of Chinese yam and 10 parts of poria cocos.

The invention provides a preparation method of a stomach medicine, which comprises the following steps:

(1) preparing materials, weighing raw materials of the pleione pleionis, the bletilla, the clove, the dried orange peel, the lily, the radix pseudostellariae, the hawthorn, the Chinese yam and the poria cocos according to parts by mass, and removing dust and impurities;

(2) pretreating raw materials, namely putting the raw materials weighed in the step (1) into a traditional Chinese medicine cleaning machine for cleaning, airing all the cleaned raw materials, putting the dried raw materials into a microwave dryer for drying and sterilizing, and crushing the raw materials by using a crusher;

(3) extracting, namely putting the crushed raw materials into an extraction tank, adding water, and heating and refluxing in the extraction tank to extract to obtain an extracting solution;

(4) concentrating, and concentrating the obtained extractive solution to obtain concentrated soft extract;

(5) making into pill, adding shaping adjuvants into the concentrated extract to obtain pill;

(6) and (4) packaging, namely performing quality inspection on the traditional Chinese medicine pills, weighing and packaging to obtain finished stomach medicine with a certain weight.

Preferably, the extraction treatment process comprises soaking the pulverized raw materials in 8-10 times of water, heating and extracting for 2 times, each time for 1-2 hr, collecting supernatant, mixing extractive solutions, and filtering with 80-120 mesh sieve to obtain extractive solution. The concentration process comprises the steps of introducing the extracting solution into a vacuum concentration tank for vacuum heating evaporation, wherein the vacuum degree during vacuum heating is-0.08 to-0.09 MPa, and the temperature of the extracting solution is controlled to be 60-80 ℃ during heating. Vacuum concentrating the extractive solution until the relative density is 1.20-1.30, removing from the vacuum concentrating tank, placing into an evaporation pan, and concentrating until the relative density is not more than 1.40 to obtain concentrated extract. And the shaping auxiliary material is dextrin, the dextrin and the concentrated thick paste are mixed, tabletting is carried out, the mixture is rolled into pills after being twisted into strips, wet pills are formed, the dextrin is applied to the surfaces of the wet pills, the dextrin is coated on the surfaces of the wet pills, the wet pills are shaped, and finally the shaped wet pills are dried and coated to obtain finished Chinese medicinal pills.

Pharmacological description:

and (3) pleione rhizome: sweet, slightly pungent and cool. It enters liver and spleen meridians. Has the effects of clearing away heat and toxic materials, eliminating carbuncle, and resolving hard mass, and can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, snake and insect bite, and limping. It can be used for treating carbuncle, cellulitis, carbuncle, furuncle, tuberculosis, and undefined lump.

And (3) common bletilla pseudobulb: bitter, sweet, astringent and slightly cold. It enters lung, liver and stomach meridians. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin.

Clove: pungent flavor and warm nature. It enters stomach, spleen and kidney meridians. Warming middle energizer to check adverse rise of qi, tonifying kidney and supporting yang, which belong to interior-warming herbs. Flos Caryophylli has effects of resisting gastric ulcer, relieving diarrhea, promoting bile flow, relieving pain, resisting anoxia, resisting blood coagulation, resisting mutation, inhibiting bacteria, and killing parasite. It also has stomach invigorating effect, and the leachate has obvious effect of stimulating gastric secretion, and can relieve abdominal distention, nausea, emesis, etc. In addition, flos Caryophylli has inhibitory effect on various pathogenic fungi, coccus, streptococcus, and Bacillus such as pneumonia, dysentery, large intestine, typhoid, etc., and influenza virus.

Dried orange peel: pungent and bitter in flavor and warm in nature. It enters spleen and lung meridians. Regulating qi, stimulating appetite, drying dampness, resolving phlegm, treating spleen and stomach diseases, belonging to qi-regulating herbs. Adjusting the digestive system; exciting heart, enhancing myocardial contraction force, inhibiting heart rate due to excessive dosage, and increasing coronary blood flow; has certain prevention effect on arteriosclerosis caused by high fat diet; relieving asthma and eliminating phlegm; the renal blood vessels are contracted, and the urine volume is reduced; inhibiting in vitro uterus, and relaxing uterus at high concentration; enhancing immune function; anti-inflammatory; the bleeding and blood coagulation time is shortened; can promote secretion of digestive juice such as saliva and gastric juice, and eliminate intestinal gas accumulation.

Lily: cold in nature and sweet in taste. They enter heart and lung meridians. Nourish yin and moisten lung, clear heart and calm nerves. They belong to yin tonics classified under deficiency tonics.

Radix pseudostellariae: mild in nature, sweet and slightly bitter in taste. It enters spleen and lung meridians. It can be used for treating spleen deficiency, asthenia, deficiency of both qi and yin, spontaneous perspiration, thirst, and dry cough due to lung dryness.

Hawthorn fruit: slightly warm in nature, sour and sweet in taste. It enters spleen, stomach and liver meridians. Promoting digestion, strengthening spleen, promoting qi circulation and removing blood stasis, which belongs to the digestant medicine.

Chinese yam: mild in nature and sweet in taste. It enters spleen, lung and kidney meridians. Invigorating spleen and stomach, promoting fluid production, benefiting lung, invigorating kidney, and arresting seminal emission. They belong to the category of qi tonics under deficiency-tonifying herbs. It is indicated for spleen deficiency with poor appetite, chronic diarrhea, lung deficiency with dyspnea and cough, kidney deficiency with nocturnal emission, leukorrhagia, frequent micturition, deficiency heat with thirst, etc. Bran-parched rhizoma Dioscoreae has effects of invigorating spleen and invigorating stomach, and can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and leukorrhagia.

Tuckahoe, poria cocos: sweet and bland in flavor, neutral in nature, and entering heart, lung, spleen and kidney meridians; promoting diuresis, eliminating dampness, invigorating spleen, calming heart, and can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia; can be used for treating dysuria, edema, fullness, phlegm retention, cough, vomiting, nausea, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation, and amnesia.

Has the advantages that: the invention has the beneficial effects that: according to the stomach medicine and the preparation method thereof provided by the invention, medicinal and edible traditional Chinese medicinal materials are selected without side effects, and are scientifically extracted and refined by using a modern process, so that natural structures of bioactive substances and various nutritional ingredients in the traditional Chinese medicinal materials are retained to the greatest extent, and the problems of denaturation and loss of active ingredients of the traditional Chinese medicines, reduction of pharmacological activity and the like are effectively avoided; the medicine has good compatibility effect, high cure rate for various gastritis, no relapse after healing and good clinical effect.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

The stomach medicine comprises the following components in parts by weight: 8 parts of Indian iphigenia bulb, 7 parts of common bletilla pseudobulb, 8 parts of clove, 13 parts of dried orange peel, 14 parts of lily, 13 parts of radix pseudostellariae, 9 parts of hawthorn, 7 parts of Chinese yam and 8 parts of poria cocos.

Example 2

The stomach medicine comprises the following components in parts by weight: 10 parts of edible tulip, 10 parts of rhizoma bletillae, 10 parts of clove, 15 parts of dried orange peel, 15 parts of lily, 15 parts of radix pseudostellariae, 10 parts of hawthorn, 10 parts of Chinese yam and 10 parts of poria cocos.

Example 3

The stomach medicine comprises the following components in parts by weight: 12 parts of Indian iphigenia bulb, 13 parts of common bletilla pseudobulb, 12 parts of clove, 17 parts of dried orange peel, 16 parts of lily, 17 parts of heterophylly falsestarwort root, 11 parts of hawthorn, 13 parts of Chinese yam and 12 parts of poria cocos.

The process for preparing the gastric drug of examples 1-3 above was carried out as follows:

Further, the extraction treatment process comprises soaking the pulverized raw materials in 8-10 times of water, heating and extracting for 2 times, each time for 1-2 hr, collecting supernatant, mixing extractive solutions, and filtering with 80-120 mesh sieve to obtain extractive solution. The concentration process comprises the steps of introducing the extracting solution into a vacuum concentration tank for vacuum heating evaporation, wherein the vacuum degree during vacuum heating is-0.08 to-0.09 MPa, and the temperature of the extracting solution is controlled to be 60-80 ℃ during heating. Vacuum concentrating the extractive solution until the relative density is 1.20-1.30, removing from the vacuum concentrating tank, placing into an evaporation pan, and concentrating until the relative density is not more than 1.40 to obtain concentrated extract. And the shaping auxiliary material is dextrin, the dextrin and the concentrated thick paste are mixed, tabletting is carried out, the mixture is rolled into pills after being twisted into strips, wet pills are formed, the dextrin is applied to the surfaces of the wet pills, the dextrin is coated on the surfaces of the wet pills, the wet pills are shaped, and finally the shaped wet pills are dried and coated to obtain finished Chinese medicinal pills.

Clinical experiments on treating stomach diseases:

the experimental subjects are patients with gastropathy, 400 patients are obtained in total, and the experimental subjects are randomly divided into 4 groups, and each group contains 100 patients; the first 3 groups were administered the stomach drugs of examples 1-3 three times a day, and the 4 th group was a control group administered the commercially available stomach drugs three times a day at the same time period, and the therapeutic effect on gastropathy was examined; the therapeutic effect judgment standard is as follows: after the medicine is taken for 7 days, the symptoms such as upper abdomen discomfort or pain, nausea, vomiting, diarrhea, inappetence and the like completely disappear, all vital signs are in a normal range, the mental state is good, and no relapse occurs within 20 days, namely the medicine is judged to be cured; after the medicine is taken for 15 days, symptoms such as upper abdomen discomfort or pain, nausea, vomiting, diarrhea, inappetence and the like are obviously improved, and each vital sign gradually approaches to a normal range, so that the treatment is judged to be effective; after the patient takes the medicine for 15 days, symptoms such as epigastric discomfort or pain, nausea, vomiting, diarrhea, inappetence and the like do not show any improvement signs, and even the condition is developed, namely the condition is judged to be invalid.

The results are shown in Table 1:

table 1: experimental comparison result of effect of treating gastropathy

	Recovery rate (%)	Effective rate (%)	Inefficiency (%)
				Example 1	85	10	5
Example 2	87	11	2
				Example 3	86	9	5
Control group	20	44	36

As can be seen from Table 1, the total effective rate of the stomach medicine for treating the stomach diseases is more than 95%, the cure rate is more than 85%, and the stomach medicine has remarkable treatment effect and is worthy of popularization and application.

According to the stomach medicine and the preparation method thereof provided by the invention, medicinal and edible traditional Chinese medicinal materials are selected without side effects, and are scientifically extracted and refined by using a modern process, so that natural structures of bioactive substances and various nutritional ingredients in the traditional Chinese medicinal materials are retained to the greatest extent, and the problems of denaturation and loss of active ingredients of the traditional Chinese medicines, reduction of pharmacological activity and the like are effectively avoided; the medicine has good compatibility effect, high cure rate for various gastritis, no relapse after healing and good clinical effect.

The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The stomach medicine is characterized by comprising the following components: edible tulip, rhizoma bletillae, clove, dried orange peel, lily, radix pseudostellariae, hawthorn, yam and poria cocos.

2. The stomach medicine according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 8-12 parts of edible tulip, 7-13 parts of rhizoma bletillae, 8-12 parts of clove, 13-17 parts of dried orange peel, 14-16 parts of lily, 13-17 parts of radix pseudostellariae, 9-11 parts of hawthorn, 7-13 parts of Chinese yam and 8-12 parts of poria cocos.

3. The stomach medicine according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 10 parts of edible tulip, 10 parts of rhizoma bletillae, 10 parts of clove, 15 parts of dried orange peel, 15 parts of lily, 15 parts of radix pseudostellariae, 10 parts of hawthorn, 10 parts of Chinese yam and 10 parts of poria cocos.

4. The preparation method of the stomach medicine is characterized by comprising the following steps:

5. The method for preparing a gastric drug according to claim 4, wherein: the extraction treatment process comprises soaking the pulverized raw materials in 8-10 times of water, heating and extracting for 2 times, each time for 1-2 hr, collecting supernatant, mixing extractive solutions, and filtering with 80-120 mesh sieve to obtain extractive solution.

6. The method for preparing a gastric drug according to claim 4, wherein: the concentration process comprises the steps of introducing the extracting solution into a vacuum concentration tank for vacuum heating evaporation, wherein the vacuum degree during vacuum heating is-0.08 to-0.09 MPa, and the temperature of the extracting solution is controlled to be 60-80 ℃ during heating.

7. The method for preparing a gastric drug according to claim 6, wherein: vacuum concentrating the extractive solution until the relative density is 1.20-1.30, removing from the vacuum concentrating tank, placing into an evaporation pan, and concentrating until the relative density is not more than 1.40 to obtain concentrated extract.

8. The method for preparing a gastric drug according to claim 4, wherein: and the shaping auxiliary material is dextrin, the dextrin and the concentrated thick paste are mixed, tabletting is carried out, the mixture is rolled into pills after being twisted into strips, wet pills are formed, the dextrin is applied to the surfaces of the wet pills, the dextrin is coated on the surfaces of the wet pills, the wet pills are shaped, and finally the shaped wet pills are dried and coated to obtain finished Chinese medicinal pills.