CN114129691A - A Chinese medicinal composition for treating stagnation of qi due to depression of liver and mammary gland diseases - Google Patents
A Chinese medicinal composition for treating stagnation of qi due to depression of liver and mammary gland diseases Download PDFInfo
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- CN114129691A CN114129691A CN202111533482.3A CN202111533482A CN114129691A CN 114129691 A CN114129691 A CN 114129691A CN 202111533482 A CN202111533482 A CN 202111533482A CN 114129691 A CN114129691 A CN 114129691A
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Abstract
The invention relates to a traditional Chinese medicine composition for treating liver depression, qi stagnation and breast diseases, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating liver depression, qi stagnation and breast diseases comprises, by weight, 20 parts of snakegourd fruit, 15 parts of green tangerine peel, 15 parts of hawthorn, 20 parts of selfheal, 15 parts of Chinese angelica, 10 parts of rhizoma sparganii, 15 parts of semen cuscutae, 30 parts of oyster, 10 parts of curcuma zedoary, 15 parts of rhizoma alismatis, 30 parts of radix clematidis, 10 parts of liquorice, 20 parts of dandelion, 15 parts of edible tulip, 15 parts of fructus forsythiae and 10 parts of beautiful sweetgum fruit. The Chinese medicinal composition can be used for treating hyperplasia of mammary glands, breast nodule, stagnation of qi due to stagnation of the liver-qi, nodules of breast, etc., and has good therapeutic effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating liver depression, qi stagnation and breast diseases.
Background
The hyperplasia of mammary glands refers to single or multiple benign hyperplasia of mammary ducts, mammary lobules, acinar epithelium and fibrous tissues. Has the main clinical characteristics of the breast distending pain and multiple breast lumps which are aggravated periodically. The incidence rate is reported to be about 10% in China, and is frequently seen in women of 30-50 years old, and also in men.
The etiology of cyclomastopathy is not fully understood in western medicine. It is thought to be related to endocrine disturbance and mental factors. The relative increase of estrogen is an important reason for the decrease of lutein secretion. It is thought that many factors, such as nerves, immunity and trace elements, can cause imbalance of various endocrine hormones in the body. The external environment, working and living conditions, interpersonal relationship, neuropsychiatric factors caused by various stresses and the like of human survival can change the internal environment of the human body, thereby affecting the functions of an endocrine system and further causing the secretion of one or more hormones to be abnormal. For example, in a long-term stress-anxiety state, increased opiate tone, altered neurotransmitter environment, and estrogen/dopamine dysregulation occur, leading to increased PRL secretion, which may lead to or exacerbate cyclomastopathy. Western medicines for treating hyperplasia of mammary glands are mainly endocrine regulating hormone medicines, iodine preparations and vitamin medicines for adjuvant therapy, and the existing medicines are not ideal. The reason is that the female mammary gland is used as a target organ of sex hormone, and is in a periodic change of periodic hyperplasia, proliferation and secretion state from puberty to menopause, then hyperplasia subsides, secretion absorption and tissue restoration are cyclically and repeatedly carried out, hormone targets are numerous, dosage and medication time are difficult to grasp, the control is easy to cause, and side effects are numerous. Therefore, for hyperplasia of mammary glands, many doctor of Western medicine also recommend the treatment of traditional Chinese medicine.
According to the traditional Chinese medicine, liver depression and qi stagnation, emotional internal injury, qi stagnation and qi and blood circulation are considered to be important factors causing breast pain and lumps. The liver and kidney meridians are closely related to the breast, and the thoroughfare and conception vessels are the second. Liver depression, qi stagnation and emotional internal injury have important effects in the pathogenesis of nodules of breast. Depression, qi stagnation, qi and blood loss, accumulation in the stomach and breast collaterals, obstruction of the channels and collaterals of the breast, and pain caused by obstruction of the channels and collaterals; liver qi transverse adversely affecting the stomach, spleen failing to transport and transform, phlegm turbidity produced internally, qi stagnation and blood stasis with phlegm accumulation as the core, and retained in milk along the meridians, so the milk is caked. The deficiency of liver and kidney and the disorder of Chong and ren meridians are also the important causes of mammary nodules. Kidneys are the root of the five zang organs, and kidneys generate essence to generate sex-stimulating essence, which stimulates Chong and ren meridians, and the Chong and ren meridians descend to the uterus, connect the breasts, and circulate qi and blood, with the milk going upwards and the meridian going downwards. For kidney-qi deficiency, disharmony of thoroughfare and conception vessels, qi and blood stagnation, accumulation of blood stasis in breast and uterus, or breast pain and agglomeration, or disorder of menstruation. In traditional Chinese medicine, liver soothing, qi regulating, blood circulation promoting and blood stasis removing methods are mostly adopted.
Disclosure of Invention
In view of the above, the present invention provides a Chinese medicinal composition for treating liver depression, qi stagnation and breast diseases.
In order to realize the purpose, the following technical scheme is adopted:
the traditional Chinese medicine composition for treating liver depression, qi stagnation and breast diseases comprises, by weight, 20 parts of snakegourd fruit, 15 parts of green tangerine peel, 15 parts of hawthorn, 20 parts of selfheal, 15 parts of Chinese angelica, 10 parts of rhizoma sparganii, 15 parts of semen cuscutae, 30 parts of oyster, 10 parts of curcuma zedoary, 15 parts of rhizoma alismatis, 30 parts of radix clematidis, 10 parts of liquorice, 20 parts of dandelion, 15 parts of edible tulip, 15 parts of fructus forsythiae and 10 parts of beautiful sweetgum fruit.
Wherein fructus Trichosanthis is fruit of Trichosanthes kirilowii Maxim of Cucurbitaceae. The functional indications are as follows: clear heat and wash phlegm, relieve chest stuffiness and dissipate nodulation, moisten intestines. Can be used for treating cough due to lung heat, turbid phlegm, yellow and thick phlegm, thoracic obstruction, cardialgia, acute mastitis, pulmonary abscess, and intestinal abscess with swelling and pain.
The pericarpium Citri Reticulatae viride is the unheated pericarp or young fruit of various oranges such as Fortunella margarita (lour.) Swingle or Citrus Suspensa. The functional indications are as follows: soothe the liver and break qi, dissipate nodulation and resolve phlegm. It is indicated for pain in chest, hypochondrium, stomach and epigastrium, hernia, indigestion, breast swelling, breast nodule and chronic malaria.
Fructus crataegi is fruit of Crataegus pinnatifida or Crataegus cuneata of Rosaceae. Collected in autumn when the fruit is ripe. The functional indications are as follows: promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating meat food stagnation, gastric cavity distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdomen stabbing pain, and hernia pain; hyperlipidemia. The charred fructus crataegi has effects of resolving food stagnation. Can be used for treating food stagnation and diarrhea and dysentery.
Prunellae Spica is fruit cluster of Labiatae plant, and is dried in the sun in summer when the fruit cluster is half-dry. The functional indications are as follows: clear liver heat, dissipate nodulation. It is used to treat scrofula, goiter, acute mastitis, breast cancer, ophthalmalgia, photophobia, lacrimation, dizziness, facial distortion, arthralgia and myalgia, pulmonary tuberculosis, acute infectious icterohepatitis, metrorrhagia, and leukorrhagia.
Angelica sinensis is root of Angelica sinensis Diels of Umbelliferae. The functional indications are as follows: tonify blood and regulate blood, regulate menstruation and relieve pain, moisten dryness and smooth intestines. Treating menoxenia, amenorrhea, abdominal pain, abdominal mass, metrorrhagia and metrostaxis; headache due to blood deficiency, vertigo, flaccidity arthralgia; intestinal dryness, difficulty in defecation, and severe dysentery; carbuncle, deep-rooted carbuncle, sore, traumatic injury.
Rhizoma Sparganii is tuber of Sparganii rhizoma or Sparganii rhizoma, and Sparganii rhizoma. The functional indications are as follows: break blood, move qi, resolve food stagnation and alleviate pain. It is used to treat abdominal pain, abdominal distention, amenorrhea, postpartum abdominal pain due to blood stasis, traumatic injury, stagnation of qi and blood, and pain in heart and abdomen. Sores and swelling are hard.
Semen Cuscutae is seed of Cuscuta chinensis or Cuscuta chinensis of Convolvulaceae. The functional indications are as follows: tonify liver and kidney, replenish essence and marrow, improve vision. It is indicated for soreness of waist and knees, seminal emission, diabetes, dribbling urine and dim eyesight.
Concha Ostreae is shell of Ostrea gigas Thunb, Ostrea gigas Thunb or Ostrea gigas Thunb of Ostreidae. The functional indications are as follows: astringe yin, subdue yang, check sweating, astringe essence, resolve phlegm and soften hard masses. It is indicated for fright epilepsy, vertigo, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter.
Curcumae rhizoma is the rhizome of Curcuma zedoaria of Zingiberaceae. The functional indications are as follows: break blood and move qi, resolve food stagnation and alleviate pain. Can be used for treating abdominal pain due to blood stasis, hepatosplenomegaly, abdominal distention and pain, abdominal accumulation, amenorrhea due to blood stasis, traumatic injury, and food stagnation.
Alismatis rhizoma is tuber of Alismatis rhizoma of Alismataceae. The functional indications are as follows: induce diuresis, drain dampness and purge heat. It is used to treat dysuria, edema, emesis, dysentery, phlegm-fluid retention, tinea pedis, gonorrhea, and hematuria.
Radix Clematidis is root of Clematis chinensis Osbeck of Ranunculaceae. Collected in autumn, removed stems and leaves, fibrous roots and soil, and dried in the sun. The functional indications are as follows: dispel wind-damp, unblock meridians, resolve phlegm and saliva, disperse accumulation of pathogen. It can be used for treating gout, obstinate arthralgia, cold pain of waist and knee, loempe, malaria, abdominal mass, tetanus, tonsillitis, and bone sticking throat.
Radix Glycyrrhizae is the root and rhizome of Glycyrrhiza uralensis Fisch of Leguminosae. The functional indications are as follows: harmonize the middle energizer and relieve urgency, moisten lung, remove toxicity, and harmonize the recipe. It is stir-baked to treat weakness of spleen and stomach, poor appetite, abdominal pain, loose stool, fatigue, fever, consumptive lung disease, cough, palpitation, fright epilepsy; unprocessed, indicated for swollen and sore throat, peptic ulcer, abscess, deep-rooted carbuncle, sores and ulcers, relieving toxicity of herbs and food poisoning.
Herba Taraxaci is whole plant with root of herba Taraxaci of Compositae. The functional indications are as follows: clear heat and remove toxicity, induce diuresis and dissipate nodulation. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
Pseudobulbus Cremastrae Seu pleiones is dry pseudobulb of Rhododendron simsii, Pleionea or Pleionea yunnanensis of Orchidaceae. The functional indications are as follows: clear heat and remove toxicity, resolve phlegm and dissipate nodulation. Can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, lymphoid tuberculosis, snake and insect bite.
Fructus forsythiae is dried fruit of Forsythia suspensa (Thunb.) Vahl of Oleaceae. The functional indications are as follows: clear heat and remove toxicity, resolve swelling and dissipate nodulation. Can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, macula, and stranguria with heat.
Fructus Lipuidambaris is fruit of Liquidambar formosana Hance of Hamamelidaceae. The functional indications are as follows: dispel wind, dredge collaterals, induce diuresis and remove dampness. It is indicated for arthralgia of limbs, spasm of hand and foot, stomachache, edema, distention, amenorrhea, oliguria, carbuncle, cellulitis, hemorrhoid, scabies, tinea and eczema.
The dosage form of the traditional Chinese medicine composition of the invention is not particularly limited, and can be granules, capsules, tablets, decoction, oral liquid, bagged steeping drug and the like.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine composition can treat hyperplasia of mammary glands, breast nodules, stagnation of qi due to depression of the liver, nodules of the breast and the like, and has a good treatment effect.
Detailed Description
The present invention is further illustrated by the following examples.
Example 1
The traditional Chinese medicine composition comprises 20g of fructus trichosanthis, 15g of pericarpium citri reticulatae viride, 15g of hawthorn, 20g of selfheal, 15g of angelica sinensis, 10g of rhizoma sparganii, 15g of semen cuscutae, 30g of oyster, 10g of curcuma zedoary, 15g of rhizoma alismatis, 30g of radix clematidis, 10g of liquorice, 20g of dandelion, 15g of edible tulip, 15g of fructus forsythiae and 10g of beautiful sweetgum fruit.
Toxicity of the Chinese medicinal composition of example 1 was examined.
Selecting 40 healthy mice, 20 mice each for male and female, dividing into 2 groups, feeding one group normally, feeding the other group with the decoction of the traditional Chinese medicine composition in the example 1 except for the normal feeding (cleaning and soaking the traditional Chinese medicine composition, adding 3-6 times of distilled water or deionized water, decocting for 1-3h, filtering to obtain the decoction, repeating the steps for two times, combining the obtained decoctions, concentrating to 200mL to obtain the decoction of the traditional Chinese medicine composition), and continuously administering 5g of the decoction for 30 days every day. The mice were observed for growth status and active diet from the period of administration to one week after the discontinuation of the administration, and tested for hematuria routine. Compared with the control group, the mice in the experimental group have no difference. The traditional Chinese medicine composition in the example 1 is proved to be safe and reliable.
The therapeutic effect of the Chinese medicinal composition of example 1 was examined.
1. According to the Chinese medicine administration 'diagnosis curative effect standard of traditional Chinese medicine syndrome' (diffuse distending pain, dull pain and dull pain of breast, related to mood change and menstrual cycle, aggravation before menstruation and disappearance after menstruation; flat lumps with tenderness, lack of clear border and weak connection with surrounding tissues in the upper quadrant outside the breast, color Doppler ultrasound prompting mammary gland hyperplasia symptoms, infrared fluoroscopy mammary gland with unclear texture and gray symptom with increased and thickened blood vessel network; and X-ray radiography is normal in whole eyes):
firstly, healing: clinical symptoms and lumps completely disappear, and the breast is transparent and B-ultrasonic shows normal;
secondly, effect is displayed: clinical symptoms and lumps basically disappear after treatment, and no relapse occurs in half a year after the medicine is stopped; or the maximum diameter of the lump is reduced by more than 1/2, the clinical symptoms are obviously improved, and the breast penetration and B-ultrasonic are basically normal;
③ effective: the lump diameter is reduced to 1/2, the pain is relieved, and the breast penetration and B-ultrasound are slightly changed;
fourthly, invalidation: pain and other clinical symptoms do not improve or even worsen, and the mass does not shrink or rather increases and becomes hard, or the breast pain alone is relieved without shrinking the mass.
Wherein the total effect of the healing, the obvious effect and the effective is taken as the total effect.
2. The administration method comprises cleaning the Chinese medicinal composition, soaking, adding 3-6 times of distilled water or deionized water, decocting for 1-3 hr, filtering to obtain decoction, repeating twice, mixing the decoctions, concentrating to 200mL to obtain Chinese medicinal composition decoction, and treating twice a day in the morning and evening, each time 100mL, and one month as one treatment course. Raw, cold, pungent and alcohol should not be eaten during medication.
3. Clinical trial
Selecting 50 patients with liver depression and qi stagnation type hyperplasia of mammary glands, wherein the patients are 20-55 years old, 5 months-6 years old, 22 cases of unilateral hyperplasia of mammary glands and 38 cases of bilateral hyperplasia of mammary glands. Clinical data are shown in table 1.
TABLE 1
| Number of cases | Cure of disease | Show effect | Is effective | Invalidation | High efficiency |
| 50 | 26 | 13 | 10 | 1 | 98％ |
As can be seen from Table 1, the traditional Chinese medicine composition provided by the invention has a good treatment effect on liver depression and qi stagnation type hyperplasia of mammary glands.
It should be understood that the above-described embodiments are merely examples for clarity of description and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither necessary nor exhaustive of all embodiments. And obvious variations or modifications of the invention may be made without departing from the spirit or scope of the invention.
Claims (2)
1. The traditional Chinese medicine composition for treating liver depression, qi stagnation and breast diseases is characterized by comprising, by weight, 20 parts of snakegourd fruit, 15 parts of green tangerine peel, 15 parts of hawthorn fruit, 20 parts of selfheal, 15 parts of Chinese angelica, 10 parts of common burreed rhizome, 15 parts of south dodder seed, 30 parts of oyster, 10 parts of curcuma zedoary, 15 parts of oriental waterplantain rhizome, 30 parts of clematis root, 10 parts of liquorice, 20 parts of dandelion, 15 parts of Indian iphigenia bulb, 15 parts of weeping forsythia and 10 parts of beautiful sweetgum fruit.
2. The Chinese medicinal composition for treating liver depression, qi stagnation and breast diseases according to claim 1, wherein the dosage form is granules, capsules, tablets, decoction, oral liquid or bagged steeping drug.
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| CN105311550A (en) * | 2014-06-30 | 2016-02-10 | 黄钰 | Decoction containing radix bupleuri and used for treating hyperplasia of mammary glands |
| CN107050397A (en) * | 2017-06-22 | 2017-08-18 | 河南中医药大学 | A kind of Chinese medicine composition for treating the caused by hepatic stagnation qi stagnation proliferation of mammary gland and preparation method thereof |
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