CN114159542A - Composition for treating gynecological diseases and female infertility, application and preparation method thereof - Google Patents

Composition for treating gynecological diseases and female infertility, application and preparation method thereof Download PDF

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Publication number
CN114159542A
CN114159542A CN202210080700.0A CN202210080700A CN114159542A CN 114159542 A CN114159542 A CN 114159542A CN 202210080700 A CN202210080700 A CN 202210080700A CN 114159542 A CN114159542 A CN 114159542A
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China
Prior art keywords
parts
composition
seed
raw materials
root
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Pending
Application number
CN202210080700.0A
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Chinese (zh)
Inventor
孔庆博
张建华
王丹
吴炜
李美懿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guodingshanhe Hainan Pharmaceutical Group Co ltd
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Guodingshanhe Hainan Pharmaceutical Group Co ltd
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Priority to CN202210080700.0A priority Critical patent/CN114159542A/en
Publication of CN114159542A publication Critical patent/CN114159542A/en
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Abstract

The invention discloses a composition for treating gynecological diseases and female infertility, and application and a preparation method thereof, wherein the composition comprises the following raw materials: chinese angelica, astragalus, agkistrodon halys, clove, fennel, elsholtzia, cassia twig, red paeony root, tuckahoe, root bark of tree peony, peach kernel, radix bupleuri, rhizoma zedoariae, rhizoma sparganii, tangerine seed, turtle shell, seaweed, centipede, bunge cherry seed, tarragon, dried ginger, cassia bark, safflower, gordon euryale seed, semen brassicae, folium artemisiae argyi, garden burnet root, rhizoma corydalis, edible tulip, nacre mother of pearl, cowherb seed, myrrh, frankincense, earthworm and dragon's blood. The invention also provides the application of the composition, and the composition is used for preparing oral medicaments. The invention also provides a preparation method of the medicament. The composition for treating gynecological diseases and female infertility, the application and the preparation method provided by the invention have the advantages that the obtained composition is used for preparing a comprehensive medicament, and the health of patients can be effectively recovered aiming at various types of female gynecological diseases.

Description

Composition for treating gynecological diseases and female infertility, application and preparation method thereof
Technical Field
The invention relates to a pharmaceutical composition, application and a preparation method thereof, in particular to a composition for treating gynecological diseases and female infertility, application and a preparation method thereof.
Background
The female reproductive system diseases are gynecological diseases, including vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases, etc. The gynecological diseases are common diseases and frequently encountered diseases of women. However, many people lack due knowledge of gynecological diseases, lack of health care of the body, and various bad living habits and habits, so that the physiological health of the people is gradually improved, some female diseases are entangled and cannot be cured for a long time, and great inconvenience is brought to normal life and work. Gynecological diseases are mainly divided into: gynecological inflammation, abortion, venereal disease, menoxenia, infertility, gynecological plastic, gynecological tumor, etc. 7 categories, each category has multiple small disease species. The disease can be divided into: vaginal diseases, uterine diseases, ovarian diseases, fallopian tube diseases, pelvic diseases and vulvar diseases. Millions of women with new gynecological diseases suffer from about four hundred million people every year.
At present, products which adopt components of Chinese herbal medicines, natural plants and the like are not available in domestic and world markets, and the processed and produced medicines can be used for various gynecological diseases until patients are completely recovered.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition, application and a preparation method thereof, wherein the pharmaceutical composition can be used for solving the existing problems and preparing a comprehensive medicament for treating gynecological diseases including infertility and cold uterus, and can completely cure patients and recover health.
In order to achieve the above objects, the present invention provides a composition for gynecological diseases and female infertility, wherein the composition comprises the following raw materials: chinese angelica, astragalus, agkistrodon halys, clove, fennel, elsholtzia, cassia twig, red paeony root, tuckahoe, root bark of tree peony, peach kernel, radix bupleuri, rhizoma zedoariae, rhizoma sparganii, tangerine seed, turtle shell, seaweed, centipede, bunge cherry seed, tarragon, dried ginger, cassia bark, safflower, gordon euryale seed, semen brassicae, folium artemisiae argyi, garden burnet root, rhizoma corydalis, edible tulip, nacre mother of pearl, cowherb seed, myrrh, frankincense, earthworm and dragon's blood.
The composition for treating gynecological diseases and female infertility comprises the following raw materials in parts by weight: 180-220 parts of angelica sinensis, 180-220 parts of astragalus membranaceus, 100-120 parts of viper, 60-80 parts of clove, 60-80 parts of fennel, 70-80 parts of elsholtzia, 160-200 parts of cassia twig, 160-200 parts of red peony root, 160-200 parts of poria cocos, 160-200 parts of cortex moutan, 160-200 parts of peach kernel, 80-100 parts of radix bupleuri, 350-380 parts of curcuma zedoary, 350-380 parts of rhizoma sparganii, 160-200 parts of tangerine seed, 350-380 parts of turtle shell, 350-380 parts of seaweed, 160-200 parts of bunge cherry seed, 100-140 parts of tarragon, 80-120 parts of rhizoma zingiberis, 100-140 parts of cassia bark, 180-220 parts of safflower, 180-220 parts of gordon euryale seed, 140-160 parts of semen brassicae alba, 160-200 parts of folium artemisiae argyi, 160-200 parts of garden burnet, 160-200 parts of rhizoma corydalis, 100-140 parts of Indian iphigenia bulb, 140 parts of nacre mother of pearl, 80-100 parts of cowherb, 80-100 parts of semen vaccariae, 80-100 parts of myrrh, 80-100 parts of frankincense, 100 parts of 40-50 parts of dragon's blood.
The composition for treating gynecological diseases and female infertility is characterized by further comprising 20-50 centipedes.
The composition for treating gynecological diseases and female infertility comprises the following raw materials in parts by weight: 200g of angelica sinensis, 200g of astragalus membranaceus, 110g of agkistrodon halys, 70g of clove, 70g of fennel, 75g of elsholtzia, 180g of cassia twig, 180g of red peony root, 180g of poria cocos, 180g of cortex moutan, 180g of peach kernel, 90g of radix bupleuri, 360g of curcuma zedoary, 360g of rhizoma sparganii, 180g of tangerine seed, 360g of turtle shell, 360g of seaweed, 180g of bunge cherry seed, 120g of tarragon, 100g of dried ginger, 120g of cassia bark, 200g of safflower, 200g of gorgon fruit, 150g of Chinese cabbage seed, 180g of folium artemisiae argyi, 180g of garden burnet root, 180g of rhizoma corydalis, 120g of edible tulip, 150g of mother-of-pearl, 90g of cowherb, 90g of myrrh, 90g of frankincense, 45g of earthworm and 60g of dragon's blood.
The composition for treating gynecological diseases and female infertility is characterized in that the raw materials also comprise 30 centipedes.
The invention also provides application of the composition for treating gynecological diseases and female infertility, wherein the composition is used for preparing an oral medicament.
The invention also provides a preparation method of the medicament, wherein the method comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding auxiliary materials, and making into pill or tablet.
The preparation method of the medicament comprises the step of taking the medicament by warm boiled water three times a day, wherein 9g of the medicament is taken orally each time.
The composition for gynecological diseases and female infertility, the application and the preparation method provided by the invention have the following advantages:
the invention utilizes the technologies of biological pharmacy and the like and high purification and extraction means, and is verified by the cooperation of the Chinese medical science college of the Chinese academy of sciences, so that the invention breaks through the prior art of treating and recovering female gynecological diseases, and can effectively aim at diseases including infertility caused by cold womb, non-neoplastic lesions of vulva epithelium, inflammation of vulva and vagina, inflammation of cervix, inflammatory diseases of pelvic cavity, tuberculosis of genitals, endometriosis, adenomyosis of uterus, female reproductive organ dysplasia, pelvic floor dysfunction, reproductive organ injury diseases, vulval tumors, cervical tumors and the like; and uterine tumors, including uterine fibroids, endometrial carcinoma, uterine sarcoma, ovarian tumors, fallopian tube tumors, and the like; gestational trophoblastic diseases, including hydatidiform mole, gestational trophoblastic tumor, placenta position trophoblastic tumor, etc.; reproductive endocrine diseases, including dysfunctional uterine bleeding, amenorrhea, polycystic ovary syndrome, dysmenorrhea, premenstrual syndrome, and other gynecological diseases and chronic diseases.
Detailed Description
The following further describes embodiments of the present invention.
The invention provides a composition for treating gynecological diseases and female infertility, which comprises the following raw materials: chinese angelica, astragalus, agkistrodon halys, clove, fennel, elsholtzia, cassia twig, red paeony root, tuckahoe, root bark of tree peony, peach kernel, radix bupleuri, rhizoma zedoariae, rhizoma sparganii, tangerine seed, turtle shell, seaweed, centipede, bunge cherry seed, tarragon, dried ginger, cassia bark, safflower, gordon euryale seed, semen brassicae, folium artemisiae argyi, garden burnet root, rhizoma corydalis, edible tulip, nacre mother of pearl, cowherb seed, myrrh, frankincense, earthworm and dragon's blood.
Wherein the radix Angelicae sinensis is dried root of Angelica sinensis (oliv.) Diels of Umbelliferae. Collected in late autumn, removed the reed heads and fibrous roots, and bundled into small bundles according to size and thickness after water is slightly evaporated, and then slowly smoked to dry with slow fire or smoked with sulfur, sliced for use, or mixed with wine and parched with wine. Sweet, slightly bitter, slightly numb and pungent taste, sweet and pungent taste, warm nature. It enters liver, heart and spleen meridians. Has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation, resisting cancer, resisting aging, and enhancing immunity. It can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. Can be used for promoting blood circulation, removing blood stasis, and relieving constipation.
Radix astragali is root of Astragalus membranaceus bge of Leguminosae. Digging in spring and autumn, removing soil, fibrous root and root head, drying in the sun to six or seven percent, straightening, bundling and drying in the sun. Has sweet and mild nature and taste, enters lung, spleen, liver and kidney meridians, has effects of enhancing organism immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure and broad antibacterial action, and can be used for enhancing immunity.
The Agkistrodon halys is whole body of Agkistrodon halys belonging to Viperidae. Captured in spring and summer. Harvesting, cutting open abdomen, removing viscera, making into disc, and oven drying. It can also be used in fresh. Sweet in nature and taste, warm. It enters spleen and liver meridians. Has the functions of dispelling wind, dredging meridian, relieving pain and detoxicating. Can be used for treating rheumatalgia, leprosy, lymphoid tuberculosis, sore, furuncle, scabies, hemorrhoid, and tumor.
Flos Caryophylli is the dried bud of flos Caryophylli of Myrtaceae. Picked up when the flower buds turn red from green, dried in the sun. Mainly produced in sang-jockel, madagaska, srilanca, indonesia, guangdong and hainan in China. The part used as the medicine is the dried flower buds of the plants. Removing impurities and screening out dust. It is administered by mashing. Pungent flavor and warm nature. Has the effects of warming the middle-jiao, lowering the adverse flow of qi, tonifying the kidney and supporting yang. Can be used for treating deficiency-cold of spleen and stomach, singultus emesis, anorexia vomiting and diarrhea, psychroalgia of heart and abdomen, and sexual impotence due to kidney deficiency.
Fructus Foeniculi is fruit of Foeniculum vulgare of Umbelliferae. And when the fruits are ripe for 9-10 months, cutting the whole plant, drying in the sun, removing the fruits, removing impurities, and drying in the sun. The main functional indications are as follows: warming kidney to dispel cold, harmonizing stomach and regulating qi. It can be used for treating cold hernia, lower abdomen psychroalgia, lumbago due to kidney deficiency, gastralgia, emesis, and tinea pedis.
Herba Moslae is whole grass or aerial part of Elsholtzia splendens or Boehmeria sinensis belonging to Labiatae. The plant of Elsholtzia of Labiatae is a vertical herb, and is originated from roadside, hillside, wasteland, forest, and river bank at an altitude of 3400 m. 2, pungent taste; mild in nature. Enter lung and stomach meridians. Xiang Ru has the actions of inducing sweat, relieving exterior syndrome, resolving dampness, regulating the middle warmer, inducing diuresis and alleviating edema. The main treatment is as follows: summer cold, cold fluid, headache, fever, aversion to cold, no sweating, fullness in the chest, abdominal pain, vomiting, diarrhea, edema and beriberi.
Ramulus Cinnamomi is dried twig of Cinnamomum cassia Presl of Lauraceae. Mainly produced in Guangxi, Guangdong and Yunnan provinces. Cutting off twig in spring and summer, removing leaf, drying in the sun or shade, and cutting into slices or small segments. Removing impurities, cleaning, moistening, slicing, and drying. Pungent, sweet and warm in nature; it enters heart, lung and bladder meridians. Has the effects of inducing sweat, expelling pathogenic factors from muscles, warming and activating meridians, supporting yang, and regulating qi. It can be used for treating common cold due to wind-cold, pain due to cold accumulation and blood stagnation, phlegm retention, water retention syndrome, and palpitation.
The radix Paeoniae Rubra is dried root of Ranunculaceae plant radix Paeoniae Rubra or radix Paeoniae Rubra. Collected in spring and autumn, removed rhizome, fibrous root and silt, and dried in the sun. Bitter and slightly cold. It enters liver meridian. Has the effects of clearing heat, cooling blood, promoting blood circulation and removing blood stasis. Can be used for treating heat syndrome of nutrient-blood, macula due to toxic heat, hematemesis and epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and sore. Red peony root is a famous wild genuine Chinese medicinal material, has a long history of application, large dosage, wide application and relatively rigid demand, and has a considerable number of exports every year.
Poria is dried sclerotium of Poria cocos (Schw.) wolf of Polyporaceae. Digging for more than 7-9 months, removing silt after digging, piling up to generate sweat, spreading and drying until the surface is dry, then generating sweat, repeating for a plurality of times until wrinkles appear and most of internal water is lost, and drying in the shade to obtain Poria cocos; or cutting fresh Poria according to different parts, and drying in the shade to obtain Poria block and Poria tablet. Sweet and bland in flavor, neutral in nature, and entering heart, lung, spleen and kidney meridians. Has effects in promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, oliguria, palpitation due to phlegm and fluid retention, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
Cortex moutan is also known as cortex moutan. Cortex moutan is dried root bark of Paeonia suffruticosa Andr. Produced in Anhui, Sichuan, Henan, Shandong, etc. It is applied by washing, moistening, slicing, and drying in the sun. Bitter and pungent in property and slightly cold in nature. It enters heart, liver and kidney meridians. Has effects in clearing away heat, cooling blood, promoting blood circulation, dispelling blood stasis, and relieving deficiency heat. It can be used for treating heat entering nutrient-blood, macula due to toxic heat, hematemesis and epistaxis, night fever and early coolness, anhidrosis and steaming bone, amenorrhea and dysmenorrhea, traumatic injury, carbuncle, swelling, and sore.
The semen Persicae is dry mature seed of Prunus persica or Prunus davidiana of Rosaceae. Harvesting after the fruits are ripe, removing pulp and nucleocapsid, taking out seeds, and drying in the sun. Is generally cultivated all over the country. Bitter, sweet and mild in nature and taste. It enters heart, liver and large intestine meridians. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, intestinal dryness, constipation, cough, and asthma. Has effects of promoting blood circulation, removing blood stasis, loosening bowel, and relieving constipation, and can be used for treating lung abscess, intestinal pain, and traumatic injury.
Bupleuri radix is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae; pungent and bitter in flavor and slightly cold in nature; entering liver, gallbladder and lung meridians; has the effects of harmonizing exterior and interior, soothing liver-qi stagnation, invigorating yang, and eliminating heat and malaria; can be used for treating common cold, fever, pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis.
The Curcumae rhizoma is rhizome of Curcuma zedoaria, Curcuma kwangsiensis and Curcuma wenyujin belonging to Zingiberaceae family. The zedoary is distributed in Guangdong, Guangxi, Sichuan and Yunnan provinces; curcumae rhizoma is distributed in Guangxi; wen Yu jin is produced in Zhejiang Ruian. Digging root when overground part withers in middle and last ten days of 12 months, removing soil on the rhizome, cleaning, steaming or boiling in a pot for about 15min, sun drying or oven drying, and removing fibrous root. Or soaking the rhizome in clear water, taking out, draining, moistening, slicing, and sun drying or oven drying. Pungent and bitter with warm nature. It enters liver and spleen meridians. Has the effects of promoting qi circulation, removing blood stasis, resolving food stagnation, relieving pain, resisting bacteria, inflammation and tumor, etc. It is commonly used for blood-qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, dysmenorrhea, abdominal mass and lump, and traumatic injury.
The rhizoma Sparganii is dry tuber of Sparganium crispum of Sparganiaceae. From winter to spring, the tuber is dug, the fibrous root of the stem and leaf is removed, the tuber is cleaned, the outer skin is cut off, and the tuber is dried in the sun. Sliced, unprocessed or stir-baked with vinegar. Pungent, bitter and mild in nature; it enters liver and spleen meridians. Has effects in removing blood stasis, promoting qi circulation, removing food stagnation, and relieving pain. The indications are the same as those of E Zhu, and they are reinforced by each other. However, san Leng is more apt to break blood and E Zhu is more apt to break qi.
The semen Citri Reticulatae is dry mature seed of Citrus reticulata Blanco of Rutaceae and its cultivar. Produced in Fujian, Zhejiang, Guangdong, Guangxi, Jiangxi, Hunan, Guizhou, Yunnan, Sichuan and other places. The fruits are collected after being ripe, cleaned and dried in the sun. Bitter taste and mild nature. It enters liver and kidney meridians. Has the effects of regulating qi, resolving hard mass and relieving pain. Can be used for treating hernia pain, swelling and pain of testis, mammary abscess, and nodules of breast.
Carapax Trionycis is the dorsal scale of Trionycis of Trionychidae. Catching all the year round, killing in autumn and winter, scalding in boiling water until the hard skin on the dorsal scale can be peeled off, taking out, peeling dorsal scale, removing residual meat, and sun drying. Are distributed in equal places. Salty in taste and slightly cold in nature. It enters liver and kidney meridians. Has the effects of nourishing yin, suppressing yang hyperactivity, relieving fever, removing dampness, softening hardness and dissipating stagnation. It is commonly indicated for fever due to yin deficiency, bone-steaming, fatigue-heat, yin deficiency with yang hyperactivity, dizziness, blurred vision, stirring of deficient wind, amenorrhea, mass, chronic malaria and malaria with malaria.
The Sargassum is dry algae of Sargassum pallidum or Cyrtymenia Sparsa of Sargassaceae. The former is known as Zostera marina and the latter as Zostera marina. The Artemisia annua seeds are distributed along the coast of the yellow sea and the Bohai sea in Liaoning and Shandong; cyrtymenia Sparsa is distributed in coastal region such as Liaoning, Shandong, Fujian, Zhejiang, Guangdong, etc. Collected in summer and autumn, cleaned, slightly dried, cut into segments and dried in the sun. Bitter, salty and cold in nature. It enters liver, stomach and kidney meridians. Has the effects of eliminating phlegm, softening hardness, dissipating stagnation, inducing diuresis and relieving swelling. It is commonly used for goiter, scrofula, swollen and painful testis, phlegm-fluid retention and edema.
Scolopendra is obtained by drying Scolopendra belonging to family Centipede. Catching in spring and summer, inserting bamboo chips into head and tail, straightening, and drying. It is pungent and warm in property and flavor, entering liver meridian. Has the effects of calming endogenous wind, relieving spasm, dredging collaterals, relieving pain, counteracting toxic substances and resolving masses. Can be used for treating endogenous liver wind, spasm, convulsion, infantile convulsion, apoplexy, hemiplegia, tetanus, rheumatism, headache, pyocutaneous disease, lymphoid tuberculosis, snake and insect bite.
The semen Pruni is seed of Prunus humilis Bunge, Prunus ulmarium, Prunus pedunculata pall, etc. of Rosaceae. Yu Li ren is mainly produced in Heilongjiang, Jilin, Liaoning, inner Mongolia, Hebei and Shandong. Picking in summer and autumn, collecting mature fruit, removing pulp and core shell, taking out seed, and drying. And obtaining the product. Contains amygdalin, fatty oil, saponin, etc. It is neutral in nature and bitter and sweet in taste, and enters spleen, large intestine and small intestine meridians. Moisten dryness and smooth intestine, purge qi, induce diuresis. Can be used for treating intestinal dryness due to consumption of body fluid, food stagnation, qi stagnation, abdominal distention, constipation, edema, loempe, and dysuria. Has the effects of moistening dryness, smoothing intestine, descending qi, activating stagnancy, inducing diuresis and relieving swelling.
Tarragon is a plant of the genus Artemisia of the family Compositae. Semi-shrub-like herbs. Distributed in china, mongolia, afghanistan, india (north), pakistan (north), keshmir, russia, europe (east, middle and west) and north america. The method is mainly applied to dry hillsides, grasslands, semi-desert grasslands, forest edges, field sides, roadside, dry river valleys, river banks, subalpine meadows and other areas, is also applied to the vicinity of saline-alkali beaches and is frequently grown in clusters, and local areas become main associated species of plant communities. Tarragon contains volatile oil, aldehydes as main component, and small amount of alkaloid. It can be used for summer-heat, damp fever, consumptive disease, etc. The root has pungent taste, and can be ground into powder to replace Capsici fructus as flavoring agent. Tarragon is considered an elegant flavour in french cuisine and can be used in meat, fish and egg products. Fresh tarragon vanilla can also be used in flavored vinegar for cooking. Tarragon is a good flavoring agent and can be used in some vegetable preparations, meats, sauces and soups.
The Zingiberis rhizoma is dried rhizome of Zingiber officinale Roscoe of Zingiberaceae. Pungent taste and hot property; it enters spleen, stomach, heart and lung meridians. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. The sliced ginger is called dry ginger slice when the sliced ginger is dry or dried at low temperature. Processing to obtain raw materials, removing impurities, cleaning, moistening, slicing into thick pieces or blocks, and drying. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung and resolving fluid retention. It can be used for treating abdominal psychroalgia, emesis, diarrhea, yang exhaustion, cough and asthma due to cold-fluid retention, and arthralgia due to cold-dampness.
The cortex Cinnamomi Japonici is bark of Cinnamomum japonicum Thunb of Lauraceae, and is used for treating common cold. Pungent and sweet in flavor and warm in nature. It enters spleen, stomach, liver and kidney meridians. Has the effects of warming the middle-jiao to dispel cold, regulating qi and relieving pain. Can be used for treating abdominal psychroalgia, emesis, diarrhea, soreness of waist and knees, cold hernia and abdominal pain, cold-dampness arthralgia, blood stasis, dysmenorrhea, dysentery with bloody stool, intestinal wind, traumatic injury, swelling and pain, traumatic hemorrhage, etc.
The Carthami flos is dried flower of Carthamus Tinctorius of Compositae. Collected in the shade or dried in the sun when the flowers turn yellow and red in summer. The cultivation is widely carried out all over the country. Pungent flavor and warm nature. It enters heart and liver meridians. Has the functions of promoting blood circulation to restore menstrual flow, eliminating blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.
Semen euryales is mature kernel of semen euryales of Nymphaeaceae. Distributed from Heilongjiang to Yunnan and Guangdong provinces. Collecting mature fruit in late autumn and early winter, removing pericarp, taking out seed, cleaning, removing hard shell (testa), and sun drying. Sweet and astringent taste, mild in nature. It enters spleen and kidney meridians. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia. Can be used for treating spermatorrhea, spleen deficiency, chronic diarrhea, and leukorrhagia.
Semen Brassicae campestris is the seed of Chinese cabbage. Chinese cabbage is a biennial herb of the genus Brassica in the family Brassicaceae. Chinese cabbage is originally distributed in North China and is widely cultivated in various places of China. Chinese cabbage is cold-resistant, favors cold climate, and is not suitable for planting on clay lands with poor drainage. The vegetable leaves and seeds have certain medicinal value.
The folium Artemisiae Argyi is leaf of Artemisia argyi of Compositae. Cultivating for 9 months and 2 nd month, cutting off aerial parts, picking off tender tips of leaves, and sun drying. Pungent and bitter taste, warm nature; it enters liver, spleen and kidney meridians. Has effects of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness, and relieving itching. It can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, gestational hemorrhage, menoxenia, dysmenorrhea, threatened abortion, psychroalgia of heart and abdomen, diarrhea, dysentery, cholera, spasm of muscle, leukorrhagia, eczema, scabies, tinea, hemorrhoid, and carbuncle.
The radix Sangusorbae is dried root of sanguisorba officinalis or sanguisorba longifolia of Rosaceae. Picking and digging plants when sprouting or withering in autumn in spring, removing fibrous root, cleaning, and drying, or slicing and drying while fresh. Bitter, sour, astringent and slightly cold in nature. It enters liver and large intestine meridians. Has the effects of cooling blood, stopping bleeding, removing toxic substances and healing sore. Can be used for treating hematochezia, hemorrhoidal bleeding, bloody dysentery, metrorrhagia, scald due to hot water and fire, carbuncle, swelling, and sore.
Rhizoma corydalis is also called rhizoma corydalis and rhizoma corydalis, is perennial herb of corydalis of Papaveraceae, and the medicinal part is dried tuber of corydalis tuber of Papaveraceae. Collected in early summer when stem and leaf withered, removed fibrous root, boiled in boiling water until there is no white heart, and dried in the sun. Slicing or mashing. Unprocessed or stir-baked with vinegar. Warm in nature, pungent and bitter in flavor, entering heart, spleen, liver and lung, is a wonderful product for promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain, especially known for its action of relieving pain. Rhizoma corydalis is pungent and bitter in flavor and warm in nature. Has effects in promoting blood circulation, dispelling blood stasis, regulating qi, and relieving pain. Can be used for treating pain due to qi stagnation and blood stasis, dysmenorrhea, amenorrhea, abdominal mass, puerperal stagnation, traumatic injury, and hernia pain.
The Pseudobulbus Cremastrae Seu pleiones is dry pseudobulb of Rhododendron simsii, Pleionea or Pleionea yunnanensis of Orchidaceae. The nature and taste of the Chinese medicinal herbs are sweet, slightly pungent and cool; it enters liver and spleen meridians. Has the effects of clearing away heat and toxic materials, eliminating carbuncle and resolving hard mass. It is used to treat carbuncle, cellulitis, furunculosis, scrofula, subcutaneous nodule, and lump in the abdomen. Has wide application in various tumors in recent years and has good phlegm reducing effect.
The Concha Margaritifera is shell Margarita layer of Hyriopsis cumingii, Cristaria plicata or Pteriidae Pinctada martensii. Can be collected all the year round. Decocting shell with alkaline water, rinsing, removing outer black skin, and calcining to crisp. Sweet and salty in nature, cold and nontoxic. Enter heart and liver meridians. The main functional indications are as follows: pacify liver, subdue yang, arrest convulsion and stop bleeding. It is indicated for dizziness, tinnitus, palpitation, insomnia, mania, fright epilepsy, hematemesis, epistaxis, and female metrorrhagia.
Semen Vaccariae is dried mature seed of Vaccaria segetalis (L.) Garcke of Caryophyllaceae. Collecting plant when fruit is mature and pericarp is not cracked in summer, sun drying, removing seed, removing impurities, and drying in the sun for use or parching. Bitter in nature and mild in taste; it enters liver and stomach meridians. Has effects of promoting blood circulation, dredging channels, promoting lactation, resolving carbuncle, inducing diuresis, and treating stranguria. Can be used for treating amenorrhea due to blood stasis, dysmenorrhea, dystocia, puerperal galactostasis, acute mastitis, pyretic stranguria, bloody stranguria, and stranguria with stone.
Myrrha is dried resin of herba Violae or herba corydalis Thalictrifoliae of Burseraceae. Is divided into natural myrrh and colloid myrrh. Distributed in somari, russian and south Arabian peninsula. Pungent and bitter in flavor and mild in nature. It enters heart, liver and spleen meridians. Has effects in removing blood stasis, relieving pain, eliminating swelling, and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, gastralgia, dysmenorrhea, amenorrhea, puerperal stagnation, abdominal mass, rheumatic arthralgia, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
The Olibanum is resin exuded from bark of Boswellia serrata belonging to Burseraceae and plants belonging to the same genus. The milk is classified into the species of frankincense somarie and the species of frankincense esophora, each of which is also in turn the same as the bead of frankincense and the original frankincense. Pungent, bitter and warm in nature. It enters heart, liver and spleen meridians. Has effects of promoting blood circulation, activating qi-flowing, relieving pain, eliminating swelling and promoting granulation. Can be used for treating thoracic obstruction, cardialgia, epigastralgia, dysmenorrhea, amenorrhea, puerperal blood stasis, abdominal pain, rheumatic arthralgia, spasm of muscles and tendons, traumatic injury, carbuncle, swelling, and pyocutaneous disease.
Pheretima, earthworm, is prepared by removing impurities and drying in the sun. The preparation method mainly comprises the methods of medicine preparation, vinegar preparation, decoction, wine preparation, oil preparation, clam powder frying, salt preparation and the like, so that the clam powder is crisp in texture, detoxified, capable of correcting odor and convenient to decoct and take. Has effects of clearing heat, arresting convulsion, dredging collaterals, relieving asthma, and promoting urination. After being stir-baked, the Chinese medicinal composition is used for treating high fever, coma, fright epilepsy and convulsion, arthralgia, cough and asthma due to lung heat, oliguria and edema, hypertension and the like. Clearing heat and stopping endogenous wind, and can be used for treating epilepsy due to hyperpyrexia and epilepsy and mania. Clearing and activating the channels and collaterals, and can be used for treating arthralgia syndrome and hemiplegia. Clear lung heat and relieve dyspnea, it is indicated for asthma due to lung heat. Clear heat and induce diuresis, and is indicated for accumulation of heat in the bladder, dysuria or anuresis.
Sanguis Draxonis is resin of dracaena cochinchinensis (lour.) Merr of Liliaceae, and has faint scent and light and astringent taste. Has effects of promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, healing sore, and promoting granulation. Can be used for treating traumatic injury, pain due to blood stasis, stagnation of qi and blood, traumatic hemorrhage, intractable abscess, and abdominal pain and diarrhea due to chronic colitis.
Preferably, the composition comprises the following raw materials in parts by weight: 180-220 parts of angelica sinensis, 180-220 parts of astragalus membranaceus, 100-120 parts of viper, 60-80 parts of clove, 60-80 parts of fennel, 70-80 parts of elsholtzia, 160-200 parts of cassia twig, 160-200 parts of red peony root, 160-200 parts of poria cocos, 160-200 parts of cortex moutan, 160-200 parts of peach kernel, 80-100 parts of radix bupleuri, 350-380 parts of curcuma zedoary, 350-380 parts of rhizoma sparganii, 160-200 parts of tangerine seed, 350-380 parts of turtle shell, 350-380 parts of seaweed, 160-200 parts of bunge cherry seed, 100-140 parts of tarragon, 80-120 parts of rhizoma zingiberis, 100-140 parts of cassia bark, 180-220 parts of safflower, 180-220 parts of gordon euryale seed, 140-160 parts of semen brassicae alba, 160-200 parts of folium artemisiae argyi, 160-200 parts of garden burnet, 160-200 parts of rhizoma corydalis, 100-140 parts of Indian iphigenia bulb, 140 parts of nacre mother of pearl, 80-100 parts of cowherb, 80-100 parts of semen vaccariae, 80-100 parts of myrrh, 80-100 parts of frankincense, 100 parts of 40-50 parts of dragon's blood.
The raw material also comprises 20-50 centipedes.
More preferably, the raw materials of the composition comprise by weight: 200g of angelica sinensis, 200g of astragalus membranaceus, 110g of agkistrodon halys, 70g of clove, 70g of fennel, 75g of elsholtzia, 180g of cassia twig, 180g of red peony root, 180g of poria cocos, 180g of cortex moutan, 180g of peach kernel, 90g of radix bupleuri, 360g of curcuma zedoary, 360g of rhizoma sparganii, 180g of tangerine seed, 360g of turtle shell, 360g of seaweed, 180g of bunge cherry seed, 120g of tarragon, 100g of dried ginger, 120g of cassia bark, 200g of safflower, 200g of gorgon fruit, 150g of Chinese cabbage seed, 180g of folium artemisiae argyi, 180g of garden burnet root, 180g of rhizoma corydalis, 120g of edible tulip, 150g of mother-of-pearl, 90g of cowherb, 90g of myrrh, 90g of frankincense, 45g of earthworm and 60g of dragon's blood.
The raw materials preferably also comprise 30 centipedes.
The raw materials are wild Chinese herbal medicines, and perennial Chinese herbal medicines are five years or more. The material is obtained from wild rare animals and plants, and can be artificially cultured and planted under the condition that conditions are not allowed, or other substitutes with the same effect and similar effect.
The invention also provides the application of the composition for treating gynecological diseases and female infertility, and the composition is used for preparing oral medicaments.
The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding auxiliary materials, and making into pill or tablet.
The auxiliary materials adopted are the common auxiliary materials used in the pharmaceutical technology and known by the technical personnel in the field.
Other specific conditions and equipment, etc. employed in the process are known to those skilled in the art.
The preparation is taken with warm boiled water for three times a day, and 9g is taken orally each time.
The compositions for treating gynecological diseases and female infertility, and the use and preparation method thereof provided by the present invention are further described below with reference to the examples.
Example 1
A composition for gynecological diseases and female infertility, which comprises the following raw materials by weight: 200g of angelica sinensis, 200g of astragalus membranaceus, 110g of agkistrodon halys, 70g of clove, 70g of fennel, 75g of elsholtzia, 180g of cassia twig, 180g of red peony root, 180g of poria cocos, 180g of cortex moutan, 180g of peach kernel, 90g of radix bupleuri, 360g of curcuma zedoary, 360g of rhizoma sparganii, 180g of tangerine seed, 360g of turtle shell, 360g of seaweed, 180g of bunge cherry seed, 120g of tarragon, 100g of dried ginger, 120g of cassia bark, 200g of safflower, 200g of gorgon fruit, 150g of Chinese cabbage seed, 180g of folium artemisiae argyi, 180g of garden burnet root, 180g of rhizoma corydalis, 120g of edible tulip, 150g of mother-of-pearl, 90g of cowherb, 90g of myrrh, 90g of frankincense, 45g of earthworm and 60g of dragon's blood.
The raw materials also comprise 30 centipedes.
The embodiment also provides the application of the composition for treating gynecological diseases and female infertility, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding adjuvants, and making into pill.
The obtained preparation is taken with warm boiled water for three times a day, and 9g is taken orally each time.
Example 2
A composition for gynecological diseases and female infertility, which comprises the following raw materials by weight: 180g of angelica, 180g of astragalus, 100g of agkistrodon halys, 60g of clove, 60g of fennel, 70g of elsholtzia, 160g of cassia twig, 160g of red paeony root, 160g of tuckahoe, 160g of cortex moutan, 160g of peach kernel, 80g of radix bupleuri, 350g of curcuma zedoary, 350g of rhizoma sparganii, 160g of tangerine seed, 350g of turtle shell, 350g of seaweed, 160g of bunge cherry seed, 100g of tarragon, 80g of dried ginger, 100g of cassia bark, 180g of safflower, 180g of gorgon fruit, 140g of Chinese cabbage seed, 160g of folium artemisiae argyi, 160g of garden burnet root, 160g of rhizoma corydalis, 100g of Indian iphigenia bulb, 140g of mother of pearl, 80g of cowherb, 80g of myrrh, 80g of frankincense, 40g of earthworm and 50g of dragon's blood.
The raw materials also comprise 20 centipedes.
The embodiment also provides the application of the composition for treating gynecological diseases and female infertility, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding auxiliary materials, and tabletting to obtain tablets.
The obtained preparation is taken with warm boiled water for three times a day, and 9g is taken orally each time.
Example 3
A composition for gynecological diseases and female infertility, which comprises the following raw materials by weight: 220g of Chinese angelica, 220g of astragalus, 120g of viper, 80g of clove, 80g of fennel, 80g of elsholtzia, 200g of cassia twig, 200g of red peony root, 200g of tuckahoe, 200g of cortex moutan, 200g of peach kernel, 100g of radix bupleuri, 380g of curcuma zedoary, 380g of rhizoma sparganii, 200g of tangerine seed, 380g of turtle shell, 380g of seaweed, 200g of bunge cherry seed, 140g of tarragon, 120g of dried ginger, 140g of cassia bark, 220g of safflower, 220g of gordon euryale seed, 160g of Chinese cabbage seed, 200g of folium artemisiae argyi, 200g of garden burnet, 200g of rhizoma corydalis, 140g of Indian iphigenia bulb, 160g of mother-of pearl, 100g of cowherb seed, 100g of myrrh, 100g of frankincense, 50g of earthworm and 80g of dragon's blood.
The raw materials also comprise 50 centipedes.
The embodiment also provides the application of the composition for treating gynecological diseases and female infertility, and the composition is used for preparing oral medicaments.
The embodiment also provides a preparation method of the medicament, which comprises the following steps: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding auxiliary materials, and making into pill or tablet.
The obtained preparation is taken with warm boiled water for three times a day, and 9g is taken orally each time.
The raw materials adopted in the embodiments of the invention respectively accord with the corresponding national standards and regulations.
Clinical trials of the medicament prepared by the embodiments of the invention prove that the composition has obvious efficacy, and can effectively recover the health of patients aiming at various types of female gynecological diseases.
The invention provides a composition for treating gynecological diseases and female infertility, and application and a preparation method thereof.
The composition also has the characteristics of reasonable formula, small using amount, obvious effect, no toxic or side effect, quick response and the like, and has the advantages of simple and easily obtained components, convenient processing, low price, high quality, economy, practicability and the like. The obtained preparation is also called Taiyin uterus-fixing pill.
The invention is based on the differentiation of symptoms and signs of traditional Chinese medicine, aims at the etiology and pathogenesis of the disease, utilizes the compatibility principle that medicines supplement each other, purposefully and reasonably combines the medicines according to the organization structures of monarch, minister, assistant and guide, ensures that the medicines in the formula and the compatibility thereof are screwed with the pathogenesis of the disease, and highly unifies the comprehensive effect after the medicines are combined with the established treatment method.
While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims (8)

1. A composition for gynecological diseases and female infertility, the composition comprising the raw materials: chinese angelica, astragalus, agkistrodon halys, clove, fennel, elsholtzia, cassia twig, red paeony root, tuckahoe, root bark of tree peony, peach kernel, radix bupleuri, rhizoma zedoariae, rhizoma sparganii, tangerine seed, turtle shell, seaweed, centipede, bunge cherry seed, tarragon, dried ginger, cassia bark, safflower, gordon euryale seed, semen brassicae, folium artemisiae argyi, garden burnet root, rhizoma corydalis, edible tulip, nacre mother of pearl, cowherb seed, myrrh, frankincense, earthworm and dragon's blood.
2. The composition for gynecological diseases and female infertility according to claim 1, wherein the composition comprises the following raw materials in parts by weight: 180-220 parts of angelica sinensis, 180-220 parts of astragalus membranaceus, 100-120 parts of viper, 60-80 parts of clove, 60-80 parts of fennel, 70-80 parts of elsholtzia, 160-200 parts of cassia twig, 160-200 parts of red peony root, 160-200 parts of poria cocos, 160-200 parts of cortex moutan, 160-200 parts of peach kernel, 80-100 parts of radix bupleuri, 350-380 parts of curcuma zedoary, 350-380 parts of rhizoma sparganii, 160-200 parts of tangerine seed, 350-380 parts of turtle shell, 350-380 parts of seaweed, 160-200 parts of bunge cherry seed, 100-140 parts of tarragon, 80-120 parts of rhizoma zingiberis, 100-140 parts of cassia bark, 180-220 parts of safflower, 180-220 parts of gordon euryale seed, 140-160 parts of semen brassicae alba, 160-200 parts of folium artemisiae argyi, 160-200 parts of garden burnet, 160-200 parts of rhizoma corydalis, 100-140 parts of Indian iphigenia bulb, 140 parts of nacre mother of pearl, 80-100 parts of cowherb, 80-100 parts of semen vaccariae, 80-100 parts of myrrh, 80-100 parts of frankincense, 100 parts of 40-50 parts of dragon's blood.
3. The composition for gynecological diseases and female infertility according to claim 2, wherein the raw materials further comprise 20 to 50 centipedes.
4. The composition for gynecological diseases and female infertility according to claim 2, wherein the raw materials comprise by weight: 200g of angelica sinensis, 200g of astragalus membranaceus, 110g of agkistrodon halys, 70g of clove, 70g of fennel, 75g of elsholtzia, 180g of cassia twig, 180g of red peony root, 180g of poria cocos, 180g of cortex moutan, 180g of peach kernel, 90g of radix bupleuri, 360g of curcuma zedoary, 360g of rhizoma sparganii, 180g of tangerine seed, 360g of turtle shell, 360g of seaweed, 180g of bunge cherry seed, 120g of tarragon, 100g of dried ginger, 120g of cassia bark, 200g of safflower, 200g of gorgon fruit, 150g of Chinese cabbage seed, 180g of folium artemisiae argyi, 180g of garden burnet root, 180g of rhizoma corydalis, 120g of edible tulip, 150g of mother-of-pearl, 90g of cowherb, 90g of myrrh, 90g of frankincense, 45g of earthworm and 60g of dragon's blood.
5. The composition for gynecological diseases and female infertility according to claim 4, wherein the raw materials further comprise 30 centipedes.
6. Use of a composition according to any one of claims 1 to 5 for the treatment of gynaecological disorders and female infertility, wherein the composition is used for the preparation of a medicament for internal administration.
7. A method of preparing the medicament of claim 6, wherein the method comprises: weighing the raw materials in proportion, cleaning and drying the washable raw materials, grinding and crushing all the raw materials, adding water, decocting, filtering to obtain liquid medicine, further concentrating to obtain ointment, adding auxiliary materials, and making into pill or tablet.
8. The process for the preparation of a medicament according to claim 7, wherein the medicament is administered three times daily by warm boiled water, 9g each time.
CN202210080700.0A 2022-01-24 2022-01-24 Composition for treating gynecological diseases and female infertility, application and preparation method thereof Pending CN114159542A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663050A (en) * 2021-09-29 2021-11-19 北京孔氏中医院 Composition for regulating dysmenorrhea and female endocrine, preparation method and application thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663050A (en) * 2021-09-29 2021-11-19 北京孔氏中医院 Composition for regulating dysmenorrhea and female endocrine, preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
徐静: "治疗妇科疾病的几种常用中药药理分析", 《当代医学》 *

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Application publication date: 20220311