CN113663050A - Composition for regulating dysmenorrhea and female endocrine, preparation method and application thereof - Google Patents

Abstract

The invention discloses a composition for regulating dysmenorrheal and female endocrine, a preparation method and application thereof, wherein the composition comprises the following raw materials: semen Pruni, tarragon, Zingiberis rhizoma, cortex Cinnamomi Japonici, stigma croci Sativi, semen euryales, semen Cleomis, radix Angelicae sinensis, radix astragali, Notoginseng radix, carapax et Plastrum Testudinis, carapax Trionycis, and rhizoma Ligustici Chuanxiong. The feedstock preferably comprises: 1000g of bunge cherry seed, 800g of tarragon, 600g of dried ginger, 600g of cassia bark, 150g of saffron, 800g of gordon euryale seed, 800g of white rapeseed, 350g of Chinese angelica, 350g of astragalus root, 200g of pseudo-ginseng, 280g of tortoise shell, 280g of turtle shell and 200g of ligusticum chuanxiong hort. The invention also provides the use of the composition for preparing an oral medicament. The invention also provides a preparation method of the medicament. The medicament prepared from the composition provided by the invention can be used for regulating female endocrine, treating dysmenorrhea, cold womb, infertility and the like, and effectively eliminating symptoms such as premenstrual and menstrual abdominal pain, dizziness, hypodynamia and the like.

Description

Composition for regulating dysmenorrhea and female endocrine, preparation method and application thereof

Technical Field

The invention relates to a pharmaceutical composition, a preparation method and application thereof, in particular to a composition for regulating dysmenorrheal and female endocrine, a preparation method and application thereof.

Background

Dysmenorrhea (dysmenorrhea) is one of the most common gynecological symptoms, and refers to patients with lower abdominal pain and distention before and after menstruation or during menstruation, accompanied by soreness of waist or other discomfort, and severe influence on quality of life. The dysmenorrhea is divided into primary dysmenorrhea and secondary dysmenorrhea, wherein the primary dysmenorrhea refers to dysmenorrhea caused by genital organ anergy lesion; secondary dysmenorrhea refers to dysmenorrhea caused by pelvic organic diseases, such as endometriosis and adenomyosis.

The pathogenesis of the traditional Chinese medicine is related to the body, menstrual period and special physiological environment before and after the menstrual period, and is mainly influenced by pathogenic factors during the period, so that chong and ren obstruction or cold congealing meridians are caused, qi and blood circulation is not smooth, and circulation of menstrual blood in uterus is blocked, so that 'obstruction causes pain': the disease location is chong ren and uterus, and changes into qi and blood, manifesting as pain. It is usually associated with the change of qi and blood during menstruation, which occurs with the menstrual cycle.

Modern medicine believes that the following factors are mostly involved: (1) uterine factors: the narrow cervical canal and the excessive uterine bending can cause the menstrual blood to flow unsmoothly, cause the retention of the menstrual blood, thereby stimulating the uterine contraction and causing the dysmenorrheal. When the uterus is dysplastic, the ratio of the uterus muscle to fibrous tissue is disordered, resulting in uncoordinated uterine contraction or dysmenorrheal caused by uterine malformation. (2) Endocrine factors: elevated levels of prostate in the endometrium and menstrual blood may be a major cause of dysmenorrhea. The endometrium can synthesize prostaglandin during the secretion period, and stimulate uterine contraction to cause dysmenorrhea. (3) Vasopressin: vasopressin secreted from posterior pituitary is sensitive to non-pregnant uterus, stimulates uterine contraction, especially in the case of menstrual tidal, and acts directly on the vascular wall to reduce uterine blood flow. (4) Systemic factors: may also be associated with genetic factors. Dysmenorrhea is caused by mental stress, depression, fear, and a person with a lower pain threshold.

Dysmenorrhea is a common symptom in women, but the pain of dysmenorrhea lasts for 3 days, and the affected people should be treated. The treatment of primary dysmenorrhea is mainly symptomatic treatment, and mainly aims at relieving pain and calming. However, no specific medicine or product with the functions of prevention and health care for radically treating dysmenorrheal and female endocrine problems exists in the current market.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition, a preparation method and application thereof, which are used for treating dysmenorrhea, cold womb, infertility and the like, can solve the existing problems, regulate female endocrine, and effectively eliminate symptoms such as premenstrual and menstrual abdominal pain, dizziness, hypodynamia and the like.

In order to achieve the above objects, the present invention provides a composition for regulating dysmenorrhea and female endocrine, wherein the composition comprises the following raw materials: semen Pruni, tarragon, Zingiberis rhizoma, cortex Cinnamomi Japonici, stigma croci Sativi, semen euryales, semen Cleomis, radix Angelicae sinensis, radix astragali, Notoginseng radix, carapax et Plastrum Testudinis, carapax Trionycis, and rhizoma Ligustici Chuanxiong.

The composition for regulating dysmenorrhea and female endocrine comprises the following raw materials in parts by weight: 80-120 parts of bunge cherry seed, 60-100 parts of tarragon, 50-70 parts of dried ginger, 50-70 parts of cassia bark, 10-20 parts of saffron crocus, 60-100 parts of gordon euryale seed, 60-100 parts of white rapeseed, 30-40 parts of angelica, 30-40 parts of astragalus mongholicus, 15-25 parts of pseudo-ginseng, 20-30 parts of tortoise shell, 20-30 parts of turtle shell and 15-25 parts of ligusticum chuanxiong hort.

The composition for regulating dysmenorrhea and female endocrine comprises the following raw materials in parts by weight: 1000g of bunge cherry seed, 800g of tarragon, 600g of dried ginger, 600g of cassia bark, 150g of saffron, 800g of gordon euryale seed, 800g of white rapeseed, 350g of Chinese angelica, 350g of astragalus root, 200g of pseudo-ginseng, 280g of tortoise shell, 280g of turtle shell and 200g of ligusticum chuanxiong hort.

The invention also provides application of the composition for regulating dysmenorrheal and female endocrine, wherein the composition is used for preparing an oral medicament.

The invention also provides a preparation method of the medicament, wherein the method comprises the following steps: weighing the medicines in proportion, grinding and crushing the raw materials into powder, then adding water for soaking, heating and extracting, concentrating and purifying the liquid medicine, adding auxiliary materials under a viscous state to prepare pills, or directly drying to remove residual water to obtain medicinal granules serving as medicinal granules.

The preparation method of the medicament is characterized in that the particle size range of the grinding and crushing is 20-30 meshes.

The preparation method of the medicament is characterized in that the soaking time in water is 18 hours or more.

The preparation method of the medicament comprises the step of taking the medicament in the form of granules with warm water or taking the medicament directly with the warm water.

The composition for regulating dysmenorrheal and female endocrine provided by the invention, and the preparation method and the application thereof have the following advantages:

the invention purifies the raw materials of each medicine by the biotechnology of the medicine, and the raw materials are made into the medicine to be taken with water or pills to be taken orally. The food therapy material is combined with medicines to adjust female endocrine, is used for treating dysmenorrheal, cold womb, infertility and the like, can ensure normal menstruation through adjustment, is characterized by eliminating the abnormality of menstrual cycle, menstrual period, menstrual volume and the like, and effectively eliminates the symptoms of premenstrual and menstrual abdominal pain, dizziness, hypodynamia and the like.

Detailed Description

The following further describes embodiments of the present invention.

The invention provides a composition for regulating dysmenorrheal and female endocrine, which comprises the following raw materials: semen Pruni, tarragon, Zingiberis rhizoma, cortex Cinnamomi Japonici, stigma croci Sativi, semen euryales, semen Cleomis, radix Angelicae sinensis, radix astragali, Notoginseng radix, carapax et Plastrum Testudinis, carapax Trionycis, and rhizoma Ligustici Chuanxiong.

The semen Pruni is seed of Prunus humilis Bunge, Prunus ulmarium, Prunus pedunculata pall, etc. of Rosaceae. Yu Li ren is mainly produced in Heilongjiang, Jilin, Liaoning, inner Mongolia, Hebei and Shandong. Picking in summer and autumn, collecting mature fruit, removing pulp and core shell, taking out seed, and drying. And obtaining the product. Contains amygdalin, fatty oil, saponin, etc. It is neutral in nature and bitter and sweet in taste, and enters spleen, large intestine and small intestine meridians. Moisten dryness and smooth intestine, purge qi, induce diuresis. Can be used for treating intestinal dryness due to consumption of body fluid, food stagnation, qi stagnation, abdominal distention, constipation, edema, loempe, and dysuria. Has the effects of moistening dryness, smoothing intestine, descending qi, activating stagnancy, inducing diuresis and relieving swelling.

Tarragon is a plant of the genus Artemisia of the family Compositae, a semi-shrub-like herb. Tarragon contains volatile oil, aldehydes as main component, and small amount of alkaloid. It can be used for summer-heat, damp fever, consumptive disease, etc. The root has pungent taste, and can be ground into powder to replace Capsici fructus as flavoring agent. Tarragon is considered an elegant flavour in french cuisine and can be used in meat, fish and egg products. Fresh tarragon vanilla can also be used in flavored vinegar for cooking. Tarragon is a good flavoring agent and can be used in some vegetable preparations, meats, sauces and soups.

The Zingiberis rhizoma is dried rhizome of Zingiber officinale Roscoe of Zingiberaceae. Pungent taste and hot property; it enters spleen, stomach, heart and lung meridians. Collected in winter, removed fibrous root and silt, dried in the sun or dried at low temperature. The sliced ginger is called dry ginger slice when the sliced ginger is dry or dried at low temperature. Processing to obtain raw materials, removing impurities, cleaning, moistening, slicing into thick pieces or blocks, and drying. Has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung and resolving fluid retention. It can be used for treating abdominal psychroalgia, emesis, diarrhea, yang exhaustion, cough and asthma due to cold-fluid retention, and arthralgia due to cold-dampness.

The cortex Cinnamomi Japonici is bark of Cinnamomum japonicum Thunb of Lauraceae, and is used for treating common cold. Pungent and sweet in flavor and warm in nature. It enters spleen, stomach, liver and kidney meridians. Has the effects of warming the middle-jiao to dispel cold, regulating qi and relieving pain. Can be used for treating abdominal psychroalgia, emesis, diarrhea, soreness of waist and knees, cold hernia and abdominal pain, cold-dampness arthralgia, blood stasis, dysmenorrhea, dysentery with bloody stool, intestinal wind, traumatic injury, swelling and pain, traumatic hemorrhage, etc.

Stigma croci Sativi is the upper part and stigma of stigma croci Sativi of Iridaceae. And (4) harvesting flowers in the morning of sunny days of 9-10 months, picking down stigmas, and drying to obtain the dry safflower. If the red flower is processed to make the oil moist and bright, the red flower is wet. The quality of the dried safflower is better. And (5) placing the mixture in a cool and dry place, and sealing and storing the mixture. Sweet and slightly sour in taste, moderate and mild in nature and non-toxic. Enter heart and liver meridians. Has effects of promoting blood circulation, removing blood stasis, resolving stagnation and resolving hard mass. Mainly treats melancholy, chest distress, hematemesis, typhoid fever, trance, amenorrhea, postpartum abdominal pain due to blood stasis, and traumatic injury with swelling and pain.

Semen euryales is mature kernel of semen euryales of Nymphaeaceae. Distributed from Heilongjiang to Yunnan and Guangdong provinces. Collecting mature fruit in late autumn and early winter, removing pericarp, taking out seed, cleaning, removing hard shell (testa), and sun drying. Sweet and astringent taste, mild in nature. It enters spleen and kidney meridians. Has effects in invigorating kidney, stopping nocturnal emission, invigorating spleen, relieving diarrhea, eliminating dampness, and stopping leukorrhagia. Can be used for treating spermatorrhea, spleen deficiency, chronic diarrhea, and leukorrhagia.

Semen Brassicae Capitatae is seed of Cleomis japonica of Cleomis family. Nature and taste: bitter, pungent, warm and slight toxic. The efficacy is as follows: has effects in promoting blood circulation, relieving pain, expelling pathogenic wind, and dispelling cold. The main treatment is as follows: each seed has effects in invigorating stomach, promoting digestion, dispelling cold, relieving pain, and treating rheumatalgia, chronic arthritis, pyocutaneous disease, bone tuberculosis, hemorrhoid, and malaria. Ye can stop diarrhea and treat traumatic injury. Radically cure gonorrhea.

The radix Angelicae sinensis is dried root of Angelica sinensis (oliv.) Diels of Umbelliferae. Collected in late autumn, removed the reed heads and fibrous roots, and bundled into small bundles according to size and thickness after water is slightly evaporated, and then slowly smoked to dry with slow fire or smoked with sulfur, sliced for use, or mixed with wine and parched with wine. Sweet, slightly bitter, slightly numb and pungent taste, sweet and pungent taste, warm nature. It enters liver, heart and spleen meridians. Has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation, resisting cancer, resisting aging, and enhancing immunity. It can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. Can be used for promoting blood circulation, removing blood stasis, and relieving constipation.

Radix astragali is root of Astragalus membranaceus bge of Leguminosae. Digging in spring and autumn, removing soil, fibrous root and root head, drying in the sun to six or seven percent, straightening, bundling and drying in the sun. Has sweet and mild nature and taste, enters lung, spleen, liver and kidney meridians, has effects of enhancing organism immunity, protecting liver, promoting urination, resisting aging, resisting stress, lowering blood pressure and broad antibacterial action, and can be used for enhancing immunity.

Notoginseng radix is dried root of Notoginseng radix of Araliaceae. Digging before blooming in late summer and early autumn or after seeds are mature in winter, removing soil, cleaning, and drying in the sun. Unprocessed or ground into fine powder. Mainly contains saponin, flavonoid glycoside, amino acid, etc. The hemostatic active ingredient is dencichine. Sweet, slightly bitter and warm in nature and taste; it enters liver and stomach meridians. Has effects of removing blood stasis, stopping bleeding, promoting blood circulation, and relieving pain. It can be used for treating hemorrhage, traumatic injury, and swelling and pain due to blood stasis.

The carapax et Plastrum Testudinis is the dorsal and ventral concha of Testudinis family. Is distributed in Jiangsu, Shanghai, Zhejiang, Anhui, Hubei, Guangxi, etc. It can be captured all the year round, and is killed in autumn and winter, or killed by boiling water, removed from dorsal and abdominal shells, removed of meat residue, and dried in the sun. Salty and sweet in flavor, slightly cold in nature. It enters liver, kidney and heart meridians. Has the functions of nourishing yin, suppressing yang, tonifying kidney, strengthening bone, nourishing blood, tonifying heart, strengthening channel and stopping metrorrhagia. It is commonly indicated for tidal fever due to yin deficiency, bone steaming, night sweat, dizziness, internal stirring of deficient wind, flaccidity of tendons and bones, heart deficiency, amnesia, metrorrhagia and metrostaxis.

Carapax Trionycis is the dorsal scale of Trionycis of Trionychidae. Catching all the year round, killing in autumn and winter, scalding in boiling water until the hard skin on the dorsal scale can be peeled off, taking out, peeling dorsal scale, removing residual meat, and sun drying. Are distributed in equal places. Salty in taste and slightly cold in nature. It enters liver and kidney meridians. Has the effects of nourishing yin, suppressing yang hyperactivity, relieving fever, removing dampness, softening hardness and dissipating stagnation. It is commonly indicated for fever due to yin deficiency, bone-steaming, fatigue-heat, yin deficiency with yang hyperactivity, dizziness, blurred vision, stirring of deficient wind, amenorrhea, mass, chronic malaria and malaria with malaria.

Rhizoma Ligustici Chuanxiong is dried rhizome of Umbelliferae plant rhizoma Ligustici Chuanxiong; digging in 5 months, removing silt, drying in the sun, and removing fibrous root. When in use, the raw sliced pieces or the wine-roasted pieces have the effects of promoting qi circulation, relieving depression, dispelling wind, eliminating dampness, promoting blood circulation and relieving pain; it can be used for treating wind-cold headache, vertigo, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, puerperal stagnation, pain, carbuncle, cellulitis, and pyocutaneous disease. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

Preferably, the raw materials comprise the following components in parts by weight: 80-120 parts of bunge cherry seed, 60-100 parts of tarragon, 50-70 parts of dried ginger, 50-70 parts of cassia bark, 10-20 parts of saffron crocus, 60-100 parts of gordon euryale seed, 60-100 parts of Chinese cabbage seed, 30-40 parts of Chinese angelica, 30-40 parts of astragalus mongholicus, 15-25 parts of pseudo-ginseng, 20-30 parts of tortoise shell, 20-30 parts of turtle shell and 15-25 parts of ligusticum chuanxiong hort.

More preferably, the feedstock comprises by weight: 1000g of bunge cherry seed, 800g of tarragon, 600g of dried ginger, 600g of cassia bark, 150g of saffron, 800g of gordon euryale seed, 800g of white rapeseed, 350g of Chinese angelica, 350g of astragalus root, 200g of pseudo-ginseng, 280g of tortoise shell, 280g of turtle shell and 200g of ligusticum chuanxiong hort.

The raw materials are wild Chinese herbal medicines, and perennial Chinese herbal medicines are five years or more. Materials from wild animals may be used in cases where conditions are not allowed, as may materials from artificially cultured animals, or other equivalent substitutes.

The invention also provides the application of the composition for regulating dysmenorrheal and female endocrine, and the composition is used for preparing oral medicaments.

The invention also provides a preparation method of the medicament, which comprises the following steps: weighing the medicines in proportion, grinding and crushing the raw materials into powder, then adding water for soaking, heating and extracting, concentrating and purifying the liquid medicine, adding auxiliary materials under a viscous state to prepare pills, or directly drying to remove residual water to obtain medicinal granules serving as medicinal granules.

Preferably, the particle size of the grinding and crushing is in the range of 20-30 meshes. Soaking in water for 18 hr or more.

The preparation comprises granule taken with warm water or pill taken directly with warm water.

The present invention provides a composition for regulating dysmenorrhea and female endocrine, and a method for preparing the same, and a use thereof, which will be described in further detail with reference to the following examples.

Example 1

A composition for regulating dysmenorrhea and female endocrine, which comprises the following raw materials by weight: 1000g of bunge cherry seed, 800g of tarragon, 600g of dried ginger, 600g of cassia bark, 150g of saffron, 800g of gordon euryale seed, 800g of white rapeseed, 350g of Chinese angelica, 350g of astragalus root, 200g of pseudo-ginseng, 280g of tortoise shell, 280g of turtle shell and 200g of ligusticum chuanxiong hort.

The present embodiment also provides the use of the composition for regulating dysmenorrhea and female endocrine, which is used for preparing an oral medicament.

The embodiment also provides a preparation method of the medicament, which comprises the steps of weighing the medicaments in proportion, grinding and crushing the raw materials into powder, wherein the particle size range of the grinding and crushing is 20-30 meshes. Then adding water for soaking for 18 hours or more. Heating for extraction, concentrating and purifying the medicinal liquid, adding adjuvants under viscous state, and making into pill, or directly drying to remove residual water to obtain medicinal granule.

The preparation comprises granule taken with warm water or pill taken directly with warm water.

Example 2

A composition for regulating dysmenorrhea and female endocrine, which comprises the following raw materials by weight: 1200g of bunge cherry seed, 1000g of tarragon, 700g of dried ginger, 700g of cassia bark, 200g of saffron, 1000g of gordon euryale seed, 1000g of Chinese cabbage seed, 400g of Chinese angelica, 400g of astragalus root, 250g of pseudo-ginseng, 300g of tortoise shell, 300g of turtle shell and 250g of ligusticum chuanxiong hort.

The present embodiment also provides the use of the composition for regulating dysmenorrhea and female endocrine, which is used for preparing an oral medicament.

The embodiment also provides a preparation method of the medicament, which comprises the steps of weighing the medicaments in proportion, grinding and crushing the raw materials into powder, wherein the particle size range of the grinding and crushing is 20-30 meshes. Then adding water for soaking for 18 hours or more. Heating for extraction, concentrating and purifying the medicinal liquid, adding adjuvants under viscous state, and making into pill, or directly drying to remove residual water to obtain medicinal granule.

The preparation comprises granule taken with warm water or pill taken directly with warm water.

Example 3

A composition for regulating dysmenorrhea and female endocrine, which comprises the following raw materials by weight: 80g of bunge cherry seed, 60g of tarragon, 50g of dried ginger, 50g of cassia bark, 10g of saffron, 60g of gordon euryale seed, 60g of white rapeseed, 30g of Chinese angelica, 30g of astragalus root, 15g of pseudo-ginseng, 20g of tortoise shell, 20g of turtle shell and 15g of ligusticum chuanxiong hort.

The present embodiment also provides the use of the composition for regulating dysmenorrhea and female endocrine, which is used for preparing an oral medicament.

The embodiment also provides a preparation method of the medicament, which comprises the steps of weighing the medicaments in proportion, grinding and crushing the raw materials into powder, wherein the particle size range of the grinding and crushing is 20-30 meshes. Then adding water for soaking for 18 hours or more. Heating for extraction, concentrating and purifying the medicinal liquid, adding adjuvants under viscous state, and making into pill, or directly drying to remove residual water to obtain medicinal granule.

The preparation comprises granule taken with warm water or pill taken directly with warm water.

The raw materials adopted in each embodiment respectively accord with the corresponding national standards.

Clinical trials of the medicament prepared in each example prove that the composition has obvious effect.

The composition has the characteristics of reasonable formula, small dosage, obvious effect, no toxic or side effect, quick response and the like, can be used for regulating female endocrine and treating dysmenorrheal, cold womb, infertility and the like, can ensure normal menstruation through regulation, eliminates the abnormal conditions of menstrual cycle, menstrual period, menstrual volume and the like, and effectively eliminates the symptoms of premenstrual, menstrual abdominal pain, dizziness, hypodynamia and the like. The obtained medicine is also named as Wu Yi Yue Han san.

According to the composition for regulating dysmenorrheal and female endocrine, the preparation method and the application thereof, through traditional Chinese medicine syndrome differentiation, aiming at the etiology and pathogenesis of diseases and by utilizing the compatibility principle that medicines supplement each other, the medicines are purposefully and reasonably combined according to the monarch, minister, assistant and guide tissue structures, the medicines in the formula and the compatibility thereof are screwed with the pathogenesis of the diseases, and the comprehensive effect after the medicines are combined is highly unified with the established treatment method.

While the present invention has been described in detail with reference to the preferred embodiments, it should be understood that the above description should not be taken as limiting the invention. Various modifications and alterations to this invention will become apparent to those skilled in the art upon reading the foregoing description. Accordingly, the scope of the invention should be determined from the following claims.

Claims (8)

1. A composition for regulating dysmenorrhea and female endocrine, the composition comprising, as raw materials: semen Pruni, tarragon, Zingiberis rhizoma, cortex Cinnamomi Japonici, stigma croci Sativi, semen euryales, semen Cleomis, radix Angelicae sinensis, radix astragali, Notoginseng radix, carapax et Plastrum Testudinis, carapax Trionycis, and rhizoma Ligustici Chuanxiong.

2. The composition for regulating dysmenorrhea and female endocrine according to claim 1, wherein said raw materials comprise, in parts by weight: 80-120 parts of bunge cherry seed, 60-100 parts of tarragon, 50-70 parts of dried ginger, 50-70 parts of cassia bark, 10-20 parts of saffron crocus, 60-100 parts of gordon euryale seed, 60-100 parts of white rapeseed, 30-40 parts of angelica, 30-40 parts of astragalus mongholicus, 15-25 parts of pseudo-ginseng, 20-30 parts of tortoise shell, 20-30 parts of turtle shell and 15-25 parts of ligusticum chuanxiong hort.

3. The composition for regulating dysmenorrhea and female endocrine according to claim 2, wherein said raw materials comprise by weight: 1000g of bunge cherry seed, 800g of tarragon, 600g of dried ginger, 600g of cassia bark, 150g of saffron, 800g of gordon euryale seed, 800g of white rapeseed, 350g of Chinese angelica, 350g of astragalus root, 200g of pseudo-ginseng, 280g of tortoise shell, 280g of turtle shell and 200g of ligusticum chuanxiong hort.

4. Use of a composition according to any one of claims 1 to 3 for the regulation of dysmenorrhea and female endocrine disorders, in the preparation of an oral medicament.

5. A method of preparing the medicament of claim 4, wherein the method comprises: weighing the medicines in proportion, grinding and crushing the raw materials into powder, then adding water for soaking, heating and extracting, concentrating and purifying the liquid medicine, adding auxiliary materials under a viscous state to prepare pills, or directly drying to remove residual water to obtain medicinal granules serving as medicinal granules.

6. The method of claim 5, wherein the size of the ground particles is in the range of 20 to 30 mesh.

7. The method for preparing the pharmaceutical preparation according to claim 5, wherein the soaking time in water is 18 hours or more.

8. The method of claim 5, wherein the preparation comprises a granule taken with warm water or a pill taken directly with warm water.