CN115006491B - Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof Download PDF

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CN115006491B
CN115006491B CN202210503336.4A CN202210503336A CN115006491B CN 115006491 B CN115006491 B CN 115006491B CN 202210503336 A CN202210503336 A CN 202210503336A CN 115006491 B CN115006491 B CN 115006491B
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吴国宏
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Abstract

The application provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following raw materials in parts by weight: 20-40 parts of dendrobium, 1-10 parts of clove, 5-20 parts of pinellia tuber, 15-30 parts of Qianlicao, 30-50 parts of jasmine flower, 10-25 parts of bighead atractylodes rhizome, 6-18 parts of radix codonopsis pilosulae and 12-28 parts of honey-fried licorice root. The traditional Chinese medicine composition has the characteristics of good curative effect, difficult recurrence and small side effect through the combined action of inhibiting or killing helicobacter pylori, protecting and repairing gastric mucosa and regulating pepsin level, thereby improving and treating chronic atrophic gastritis. In the preparation method of the traditional Chinese medicine composition, through pretreatment of different medicinal materials and mixed extraction of a plurality of methods, the precipitation effect of medicinal components of the medicine is better, and the gastritis can be better treated.

Description

Traditional Chinese medicine composition for treating chronic atrophic gastritis and preparation method thereof
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof.
Background
Atrophic gastritis, also known as chronic atrophic gastritis, is a chronic digestive system disease characterized by atrophy of the gastric mucosal epithelium and glands, a reduced number, thinning of the gastric mucosa, thickening of the mucosal base layer, or concomitant pyloroadenogenesis and intestinal adenogenesis, or atypical hyperplasia.
The etiology of atrophic gastritis is: helicobacter pylori infection; smoking, drinking, food irritation, and gastric mucosa damaging drugs; immune factors; bile or duodenal fluid reflux; constitution factors; genetic factors; metal contact; emitting; iron deficiency anemia, etc. Clinically manifested as distention and fullness of the epigastrium, pain in the epigastrium, burning heart and dyspepsia, abnormal stool and weakness, and anemia.
At present, western medicines are generally used for relieving treatment, but the curative effect on partial patients is poor, clinical symptoms are easy to relapse after stopping the medicine, the tolerance is strong, the side effect is large after long-term use, and malignant circulation is easy to form.
Disclosure of Invention
The application aims to provide the traditional Chinese medicine composition for treating the chronic atrophic gastritis, which has the characteristics of good curative effect, difficult recurrence and small side effect by inhibiting or killing helicobacter pylori, protecting and repairing gastric mucosa and regulating pepsin level.
The other aim of the application is to provide a preparation method of the traditional Chinese medicine composition for treating the chronic atrophic gastritis, and the preparation method is characterized in that different medicinal materials are pretreated and mixed and extracted by a plurality of methods, so that the precipitation effect of medicinal components of the medicine is better, and the traditional Chinese medicine composition is favorable for treating the gastritis better.
The technical problem of the application is solved by adopting the following technical scheme.
The application provides a traditional Chinese medicine composition for treating chronic atrophic gastritis, which comprises the following raw materials in parts by weight: 20-40 parts of dendrobium, 1-10 parts of clove, 5-20 parts of pinellia tuber, 15-30 parts of Qianlicao, 30-50 parts of jasmine flower, 10-25 parts of bighead atractylodes rhizome, 6-18 parts of radix codonopsis pilosulae and 12-28 parts of honey-fried licorice root.
The application provides a preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis, which comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 40-50deg.C water for 20-30min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding residue one, soaking in ethanol for 20-50 hr, percolating to obtain percolate and residue two, and extracting residue two with water under microwave to obtain extractive solution; mixing the extractive solution, percolate and volatile oil, concentrating, and drying.
The embodiment of the application has at least the following beneficial effects:
in the application, dendrobium, clove and jasmine are matched, so that the distribution of stomach flora is improved, bacterial growth is inhibited, stomach cells are protected, gastric mucosa is restored in an accelerating way, flatulence can be prevented and treated, stomach health is protected, the health is maintained, and the effects of warming the middle-jiao, regulating stomach, activating qi-flowing and relieving pain are achieved. The pinellia tuber and the bighead atractylodes rhizome are matched for use, so that gastric acid secretion can be reduced, free acidity and total acidity of gastric juice can be reduced, pepsin activity can be inhibited, gastric mucosa can be protected, gastric mucosa repair can be promoted, and the gastric mucosa barrier can be protected. Qianlicao, dangshen and honey-fried licorice root have the effects of tonifying spleen and stomach, strengthening middle-jiao and replenishing qi, strengthening spleen and promoting digestion, can relieve spasm and pain, and effectively relieve symptoms of epigastric distending pain and dyspepsia. The mixture ratio of the components is reasonable, the components complement each other and act synergistically, so that the chronic atrophic gastritis is treated from multiple aspects, and the glandular atrophy is improved.
In the application, the Qianliao grass, the jasmine flower and the honey-fried licorice root are soaked in warm water, so that the medicinal materials can be softened, the effective components can be separated out conveniently during the subsequent extraction, and the content of the effective components is improved; and then distilling and extracting are adopted, so that the volatile oil is more conveniently collected, and the loss of the volatile oil is reduced. Mixing the first filter residue with the rest materials, adding ethanol for soaking to allow the powder to be sufficiently wet and expanded, so as to be more favorable for the sufficient diffusion of ethanol and the precipitation of effective components during percolation. And extracting the second filter residue by microwave, so that the effective components in the medicinal materials can be further extracted, and the medicinal effect is further enhanced. The preparation method is simple, and the loss of active ingredients can be reduced as much as possible, so that the drug effect is enhanced, and the traditional Chinese medicine composition has better curative effect and quicker onset of action.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
It should be noted that, in the case of no conflict, the embodiments and features in the embodiments may be combined with each other. The present application will be described in detail with reference to specific examples.
A traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following raw materials in parts by weight: 20-40 parts of dendrobium, 1-10 parts of clove, 5-20 parts of pinellia tuber, 15-30 parts of Qianlicao, 30-50 parts of jasmine flower, 10-25 parts of bighead atractylodes rhizome, 6-18 parts of radix codonopsis pilosulae and 12-28 parts of honey-fried licorice root.
Dendrobium nobile is sweet in flavor, slightly cold in nature, enters stomach and kidney meridians, and has the effects of tonifying stomach, promoting fluid production, nourishing yin and clearing heat. The dendrobium has certain antipyretic and analgesic effects, can promote gastric secretion, strengthen small intestine peristalsis, promote digestion, strengthen metabolic capacity and facilitate softening and defecating; can also promote gastrointestinal motility, improve the absorption capacity of the stomach and help repair gastric mucosa; can enhance immunity, resist virus invasion, and reduce disease incidence; the polysaccharide has the effects of resisting cell mutation, eliminating aging and dead injury cells in the body, stabilizing the physiological state of the body and having stronger anti-tumor activity; can obviously improve the superoxide dismutase and HYP levels of human bodies, obviously reduce the oxidation function of organisms, and thus has the anti-aging effect.
Flos Caryophylli, pungent in flavor, warm in nature, enters stomach meridian, spleen meridian and kidney meridian, and has the effects of warming spleen and stomach, lowering adverse qi, tonifying kidney and supporting yang. The clove has the efficacies and effects of gastric ulcer resistance, diarrhea resistance, cholagogue, pain relief, hypoxia resistance, anticoagulation, mutation resistance, bacteriostasis and insect disinfestation. The clove also has the stomach strengthening effect and action, and the leaching solution has obvious gastric secretion stimulating effect and can relieve abdominal distension, nausea, vomiting and the like. In addition, flos Caryophylli has inhibitory effect on various pathogenic fungi, coccus, streptococcus, pneumonia, dysentery, bacillus such as large intestine and typhoid, and influenza virus. Eugenol as a main component of the clove has antibacterial, anesthetic, antipyretic, antioxidant and antitumor activities, can inhibit or kill helicobacter pylori, and can effectively resist invasion and breeding of helicobacter pylori.
Pinellia tuber, rhizoma Pinelliae, having warm nature and pungent taste, being toxic, entering spleen channel, stomach channel and lung channel, has the effects of drying dampness and resolving phlegm, calming adverse-rising energy and relieving vomiting, and relieving stuffiness and resolving masses, and has the effects of relieving cough, promoting vomiting and vomiting, resisting cancer, regulating gastrointestinal function and promoting bile flow. Pinellia ternate can reduce gastric acid secretion, reduce free acidity and total acidity of gastric juice, inhibit pepsin activity, protect gastric mucosa and promote repair of gastric mucosa.
Qianliao Cao is slightly bitter in taste, sweet and slightly warm in nature, has the effects of activating blood circulation to relieve pain, dispelling wind and removing dampness, strengthening spleen to promote digestion, can effectively relieve epigastric distending pain, can regulate the immune function and can improve the immunity of organisms.
Jasmine flower, cold property, light taste, flatulence elimination, pungent and sweet taste, warm nature, has the effects of regulating qi, relieving pain, warming the middle-jiao, regulating stomach, detumescence, detoxification, strengthening immune system, and has good anti-inflammatory and detoxification effects on diarrhea, abdominal pain, conjunctivitis, sore toxin and the like; has effects of removing liver fire for improving eyesight, promoting salivation, quenching thirst, eliminating phlegm, treating dysentery, expelling pathogenic wind, relieving exterior syndrome, treating fistula, strengthening teeth, invigorating qi, lowering blood pressure, tonifying heart, preventing dental caries and radiation injury, resisting cancer, and resisting aging, and can prolong life; has antibacterial, antiasthmatic, anticancer, muscles and tendons relaxing, blood circulation promoting, pathogenic wind expelling, cold expelling, spleen invigorating, stomach invigorating, heart strengthening, liver benefiting, blood pressure lowering, kidney invigorating, and essence strengthening effects; can help repair gastric mucosa, volatilize oily substances, repair gastric mucosa and help relieve epigastric distending pain; also has effects of clearing heat and detoxicating, and can protect stomach from injury.
Atractylodis rhizoma has warm nature, sweet and bitter taste, and has effects of invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, suppressing sweat and preventing miscarriage. The product has obvious and durable antidiuretic effect, and has remarkable inhibiting effect on Ehrlich carcinoma of mice, lymphosarcoma ascites tumor and 109 esophageal carcinoma; has bidirectional regulating effect on gastrointestinal system, and can be used for treating gastric ulcer; in addition, the composition has the pharmacological effects of spasmolysis, liver protection, antibiosis and the like; it also has effects in promoting gastrointestinal peristalsis, promoting gallbladder function, resisting oxidation, reducing blood sugar, resisting blood coagulation, resisting bacteria, dilating blood vessel, inhibiting heart, and tranquilizing mind.
Codonopsis pilosula is neutral in nature and sweet in taste, enters spleen meridian and lung meridian, has the effects of tonifying middle-jiao and Qi, strengthening spleen and benefiting lung, and can strengthen the stress capability and immunity of organisms, delay aging and resist ulcer. The effective components of radix Codonopsis comprise radix Codonopsis glycoside, glucose, inulin, polysaccharide, campanumaea alkali and volatile oil, and has effects in improving gastric motility, promoting gastric emptying, assisting gastric and intestinal duodenal movements, and preventing bile reflux, so as to regulate and restore gastrointestinal movement.
Roasted licorice root, radix Glycyrrhizae Praeparata, has warm nature and sweet taste, and can tonify spleen and stomach, and tonify qi and restore pulse after entering heart meridian, lung meridian, stomach meridian and spleen meridian. The honey-fried licorice root has the inhibition effect on gastric acid hypersecretion caused by histamine, can relieve gastrointestinal smooth muscle spasm, and has the effects of easing pain and resisting acid; can tonify heart qi, recover pulse, and play an antiarrhythmic role; has effects of clearing heat and detoxicating, reducing irritation to gastric mucosa, and accelerating repair of gastric mucosa. The radix Glycyrrhizae Preparata contains glycyrrhizin, glycyrrhetinic acid, and Glycyrrhrizae radix polysaccharide, and has antiinflammatory and antiallergic effects, and can regulate immunity, resist tumor and relieve pain. Therefore, the main actions of honey-fried licorice root are regulating the middle energizer, relieving urgency, moistening lung, removing toxicity and harmonizing various drugs. It is indicated for weakness of spleen and stomach, lassitude, palpitation, and intermittent pulse, and can dispel aconite toxicity.
The dendrobium, the clove and the jasmine flower are matched, which is favorable for improving the distribution of stomach flora, inhibiting the bacterial growth, protecting stomach cells, accelerating the repair of gastric mucosa, preventing and treating flatulence, protecting stomach health, being favorable for maintaining body health and playing roles in warming middle-jiao, regulating stomach, activating qi-flowing and relieving pain. The pinellia tuber and the bighead atractylodes rhizome are matched for use, so that gastric acid secretion can be reduced, free acidity and total acidity of gastric juice can be reduced, pepsin activity can be inhibited, gastric mucosa can be protected, gastric mucosa repair can be promoted, and the gastric mucosa barrier can be protected. Qianlicao, dangshen and honey-fried licorice root have the effects of tonifying spleen and stomach, strengthening middle-jiao and replenishing qi, strengthening spleen and promoting digestion, can relieve spasm and pain, and effectively relieve symptoms of epigastric distending pain and dyspepsia. The mixture ratio of the components is reasonable, the components complement each other and act synergistically, so that the chronic atrophic gastritis is treated from multiple aspects, and the glandular atrophy is improved.
In the embodiment, the traditional Chinese medicine composition further comprises 5-14 parts of cuttlefish bone, 3-9 parts of rhizoma nardostachyos and 1-5 parts of magnolia officinalis in parts by weight.
Cuttlefish bone is salty in taste, astringent and warm in nature, enters liver and kidney meridians, and has the effects of astringing to stop bleeding, stopping leukorrhagia, relieving hyperacidity and pain, and astringing dampness to heal sore. Cuttlefish bone can reduce gastric acid secretion and relieve gastralgia.
Rhizoma Nardostachyos, warm in nature, pungent and sweet in taste, enters spleen channel and stomach channel, has the effects of regulating qi to alleviate pain, relieving depression and activating spleen, and can promote qi circulation to dispel cold, relieve spasm and pain, and treat epigastric distending pain.
Magnolia officinalis, cortex Magnolia officinalis, is warm in nature, bitter and pungent in taste, enters spleen meridian, stomach meridian, lung meridian and large intestine meridian, has effects of eliminating dampness and phlegm, descending qi and eliminating fullness, and also has muscle relaxation effect; small doses excite intestinal smooth muscle, while large doses have inhibitory effects; has antiulcer effect, has remarkable central inhibiting effect, and can reduce blood pressure, resist pathogenic microorganism and resist tumor; also has effects in resisting blood platelet and inhibiting intracellular calcium flow. Magnolol in cortex Magnolia officinalis has certain inhibiting effect on duodenal spasm caused by histamine, and can regulate gastrointestinal motility function.
The cuttlefish bone, the nardostachyos root and the magnolia bark are matched with the raw materials, so that the effects of relieving pain, promoting qi circulation and dispelling cold can be enhanced, gastric acid secretion can be reduced, and epigastric distending pain can be remarkably relieved. And can strengthen and regulate gastrointestinal function, strengthen spleen and promote digestion, and improve dyspepsia symptom.
In the embodiment, the traditional Chinese medicine composition further comprises 1-8 parts of radix et rhizoma callae and 2-10 parts of cynanchum otophyllum by weight.
The radix et rhizoma Rhei can clear away heat and toxic materials, stop bleeding, and remove dampness and promote urination, and can be used for treating enteritis, dysentery, food stagnation, abdominal distention, nephritic edema, pulmonary tuberculosis, hemoptysis, metrorrhagia, traumatic injury, rheumatism, gastric ulcer and duodenal ulcer.
Before white, it is slightly warm in nature, pungent and bitter in taste, enters lung meridian, has the effects of reducing qi, resolving phlegm and relieving cough, can relieve epigastric distending pain, and has anti-inflammatory effect.
The water chestnut root, the cynanchum bungei and the raw materials are matched for use, and the water chestnut root and the cynanchum bungei have the effects of clearing heat, detoxicating and resisting inflammation, can relieve epigastric distending pain, promote gastric emptying, assist gastric and duodenal movements, prevent bile reflux, and regulate and restore gastrointestinal movements.
In the embodiment, the traditional Chinese medicine composition further comprises 3-8 parts of cardamom and 4-15 parts of murraya paniculata in parts by weight.
Fructus Amomi rotundus, warm nature, pungent taste, has effects of activating qi-flowing, warming stomach, resolving food stagnation, and relieving pain, and can be used for treating qi stagnation, food stagnation, chest distress, abdominal distention, hickory, regurgitation, malaria, etc., and is a common medicine for invigorating lung qi, invigorating spleen and stomach, and regulating primordial qi. The cardamon is rich in volatile oil such as cardamomin, camphor, borneol and the like, so that the cardamon is rich in fragrance, can remove the fishy smell and the peculiar smell of fish, has the effects of opening stomach, stimulating appetite and promoting digestion. The extract of fructus Amomi rotundus can enhance immunity of organism to tumor, and destroy peripheral protective factors of cancer cells, so that cancer tissue is easily damaged.
Murraya paniculata has warm nature, pungent and slightly bitter taste, enters liver and stomach meridians, and has the effects of promoting qi circulation, relieving pain, promoting blood circulation, removing blood stasis, removing toxin and relieving swelling. It mainly contains chemical components of coumarone extract, flavonoid, terpenoid, alkaloid and the like, and is used for treating symptoms such as gastralgia, traumatic injury, swelling and pain, acute appendicitis, snake and insect bite and the like.
The cardamom, the murraya paniculata and the raw materials are used together to further enhance the effects of strengthening qi and relieving pain, regulating stomach and eliminating, and improve the symptoms of epigastric distending pain and dyspepsia, thereby treating chronic atrophic gastritis.
A preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 40-50deg.C water for 20-30min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding residue one, soaking in ethanol for 20-50 hr, percolating to obtain percolate and residue two, and extracting residue two with water under microwave to obtain extractive solution; mixing the extractive solution, percolate and volatile oil, concentrating, and drying.
Soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 40-50deg.C water for 20-30min to soften the medicinal materials, facilitate precipitation of effective components during subsequent extraction, and increase the content of effective components, so that volatile oil has good extraction effect under the above conditions without volatilizing due to overheating; and then distilling and extracting are adopted, so that the volatile oil is more conveniently collected, and the loss of the volatile oil is reduced. Mixing the first filter residue with the rest raw materials, adding ethanol, soaking for 20-50h to allow the medicinal powder to be fully wetted and expanded, so that the medicinal powder is more beneficial to fully diffusing the ethanol, and effective components are effectively separated out during percolation. And extracting the second filter residue by microwave, so that the effective components in the medicinal materials can be further extracted, and the medicinal effect is further enhanced. The preparation method is simple, and the loss of active ingredients can be reduced as much as possible, so that the drug effect is enhanced, and the traditional Chinese medicine composition has better curative effect and quicker onset of action.
In this embodiment, the extraction temperature is 70-90deg.C and the extraction time is 30-50min. Under the condition, the volatile oil is not easy to volatilize, and the volatile oil extraction effect is best.
In the embodiment, the mass fraction of the ethanol is 60-75%, and the dosage is 0.8-1.5 times of the mass of the raw materials. Thus, the infiltration effect of the ethanol on the powder is optimal, the swelling degree of the powder is good, and the effective components in the powder can be better extracted during percolation.
In this example, the rate of percolation is 2.24-3.58mL/min. Under the condition, the precipitation speed of the effective components is higher, and the precipitation rate is higher; the method can avoid the decrease of the content of effective components caused by the excessively high flow rate and the entrainment of the medicine powder which is not completely extracted into the percolate, and the drug effect of the traditional Chinese medicine composition is reduced.
In this embodiment, the steps of mixing the extractive solution, percolate and volatile oil, and centrifuging at 800-1200r/min for 5-10min are also included. The fine particles remained in the liquid during percolation or filtration can be removed by centrifugation, so that the purity of the liquid is improved.
In the embodiment, after concentrating and drying, vitamin C, vitamin E and allicin are added, stirred and mixed to prepare tablets, granules or capsules, and the mass ratio of the three is 1:1: (0.01-0.1).
The allicin also has the functions of reducing the nitrite content in the stomach and inhibiting nitrate-reducing bacteria, can reduce the pH of gastric juice, and can obviously improve symptoms such as discomfort, fullness, dull pain, acid regurgitation, eructation, burning, inappetence and the like in gastric areas. Vitamin C, vitamin E and allicin belong to gastric mucosa nutrition factors, and can supplement gastric mucosa nutrition, accelerate gastric mucosa repair and prevent gastric mucosa injury, thereby effectively enhancing the drug effect of the traditional Chinese medicine composition; meanwhile, the gastric acidity can be reduced, various symptoms of stomach discomfort can be improved, the speed of treating gastritis can be increased, and the recovery of patients can be promoted.
The features and capabilities of the present application are described in further detail below in connection with the examples.
Example 1
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 20g of dendrobium, 1g of clove, 5g of pinellia tuber, 15g of Qianlicao, 30g of jasmine flower, 10g of bighead atractylodes rhizome, 6g of codonopsis pilosula and 12g of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 40deg.C water for 20min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding residue one, soaking in ethanol for 20 hr, percolating to obtain percolate and residue two, and extracting residue two with water under microwave to obtain extractive solution; mixing the extractive solution, percolate and volatile oil, concentrating, and drying.
Example 2
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 40g of dendrobium, 10g of clove, 20g of pinellia tuber, 30g of Qianlicao, 50g of jasmine flower, 25g of bighead atractylodes rhizome, 18g of codonopsis pilosula and 28g of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 50deg.C water for 30min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding residue one, soaking in ethanol for 50 hr, percolating to obtain percolate and residue two, and extracting residue two with water under microwave to obtain extractive solution; mixing the extractive solution, percolate and volatile oil, concentrating, and drying.
Example 3
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 30g of dendrobium, 8g of clove, 10g of pinellia tuber, 20g of Qianlicao, 40g of jasmine flower, 15g of bighead atractylodes rhizome, 10g of codonopsis pilosula and 15g of honey-fried licorice root.
A preparation method of a traditional Chinese medicine composition for treating chronic atrophic gastritis comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 45deg.C water for 25min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding residue one, soaking in ethanol for 40 hr, percolating to obtain percolate and residue two, and extracting residue two with water under microwave to obtain extractive solution; mixing the extractive solution, percolate and volatile oil, concentrating, and drying.
Example 4
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 25g of dendrobium, 5g of clove, 15g of pinellia tuber, 25g of Qianlicao, 35g of jasmine flower, 20g of bighead atractylodes rhizome, 12g of codonopsis pilosula, 20g of honey-fried licorice root, 8g of cuttlefish bone, 5g of rhizoma nardostachyos and 4g of magnolia bark. In this example, os Sepiae, radix Et rhizoma Nardostachyos and cortex Magnoliae officinalis were pulverized together with herba Dendrobii, etc., and the other preparation methods were the same as in example 3.
Example 5
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 25g of dendrobium, 5g of clove, 15g of pinellia tuber, 25g of Qianlicao, 35g of jasmine flower, 20g of bighead atractylodes rhizome, 12g of codonopsis pilosula, 20g of honey-fried licorice root, 8g of cuttlefish bone, 5g of nardostachys root, 4g of magnolia bark, 5g of horseshoe root and 6g of cynanchum venetum. In this example, os Sepiae, rhizoma Nardostachyos, cortex Magnolia officinalis, radix et rhizoma Rhei, rhizoma Cynanchi Stauntonii, herba Dendrobii, etc. were pulverized together, and the other preparation methods were the same as in example 3.
Example 6
A Chinese medicinal composition for treating chronic atrophic gastritis comprises the following raw materials: 25g of dendrobium, 5g of clove, 15g of pinellia tuber, 25g of Qianlicao, 35g of jasmine flower, 20g of bighead atractylodes rhizome, 12g of codonopsis pilosula, 20g of honey-fried licorice root, 8g of cuttlefish bone, 5g of nardostachys root, 4g of magnolia bark, 5g of horseshoe root, 6g of cynanchum zerumbet, 5g of cardamom and 10g of murraya jasminorage. In this example, os Sepiae, rhizoma Nardostachyos, cortex Magnoliae officinalis, radix et rhizoma Rhei, fructus Amomi rotundus, herba Murrayae and herba Dendrobii etc. were pulverized together, and the other preparation methods were the same as in example 3.
Example 7
The raw materials of this example are the same as those of example 6, and the preparation method thereof comprises the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 45deg.C water for 25min, and extracting at 80deg.C for 40min to obtain volatile oil and residue I; pulverizing the rest other raw materials, adding the first filter residue, adding ethanol with a mass fraction of 70% which is 1 time of the raw materials, soaking for 48 hr, percolating at a percolation speed of 2.67mL/min to obtain a percolate and a second filter residue, and extracting the second filter residue with water under microwave to obtain an extractive solution; mixing the extract, percolate and volatile oil, centrifuging at 1000r/min for 5min to obtain supernatant, concentrating, drying, adding vitamin C, vitamin E and allicin, stirring, mixing, and making into tablet, granule or capsule with the mass ratio of 1:1:0.01.
test results
140 clinical chronic atrophic gastritis testers were collected, aged 30-50 years, average age 38.6 years, shortest disease course 6 months, longest 3 years, and randomized into 7 groups of 20 people each. Clinically manifested as distention of the epigastrium, pain in the epigastrium, heartburn and dyspepsia; gastroscopy is diagnosed as the gastric mucosa being grey-white, grey or grey-yellow, and small blood vessels within the mucosa being visible.
The test method comprises the following steps: 1-7 groups correspond to the application of the traditional Chinese medicine composition of the embodiment 1-7, and the traditional Chinese medicine composition is taken twice daily, 1 time and 12.5g for 1 month.
The subjects after the administration were scored for their own conditions, and the symptom classification criteria were as follows:
TABLE 1 symptom classification criteria
Figure BDA0003636324990000121
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Figure BDA0003636324990000131
Table 2 scoring results
Figure BDA0003636324990000132
Note that: the scoring results for each group are average values for each group.
According to table 2, it can be seen from the initial score and the post-treatment score of each group, the Chinese medicinal composition of the embodiment of the present application can effectively improve symptoms such as gastric fullness, gastric cavity pain, dyspepsia, stool, listlessness, and heartburn.
The results of gastric histopathological examination of 140 subjects before and after treatment were as follows:
TABLE 3 stomach tissue pathological examination
Figure BDA0003636324990000141
According to Table 3, after the treatment by using the traditional Chinese medicine composition, the gland atrophy and the gland reduction of a tester are obviously improved, and the treatment effect on stomach tissues is better.
In conclusion, the traditional Chinese medicine composition for treating chronic atrophic gastritis disclosed by the embodiment of the application is matched with dendrobium nobile, clove and jasmine flower, so that the traditional Chinese medicine composition is beneficial to improving the distribution of stomach flora, inhibiting bacterial growth, protecting stomach cells, accelerating the repair of gastric mucosa, preventing and treating flatulence, protecting stomach health, and being beneficial to maintaining body health, and has the effects of warming the middle-jiao, regulating stomach, promoting qi circulation and relieving pain. The pinellia tuber and the bighead atractylodes rhizome are matched for use, so that gastric acid secretion can be reduced, free acidity and total acidity of gastric juice can be reduced, pepsin activity can be inhibited, gastric mucosa can be protected, gastric mucosa repair can be promoted, and the gastric mucosa barrier can be protected. Qianlicao, dangshen and honey-fried licorice root have the effects of tonifying spleen and stomach, strengthening middle-jiao and replenishing qi, strengthening spleen and promoting digestion, can relieve spasm and pain, and effectively relieve symptoms of epigastric distending pain and dyspepsia. The mixture ratio of the components is reasonable, the components complement each other and act synergistically, so that the chronic atrophic gastritis is treated from multiple aspects, and the glandular atrophy is improved.
According to the preparation method of the traditional Chinese medicine composition for treating the chronic atrophic gastritis, through pretreatment of different medicinal materials and mixed extraction of a plurality of methods, the precipitation effect of medicinal components of the medicine is better, and the traditional Chinese medicine composition is beneficial to treating the gastritis better.
The embodiments described above are some, but not all, of the embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.

Claims (6)

1. The traditional Chinese medicine composition for treating the chronic atrophic gastritis is characterized by being prepared from the following raw materials in parts by weight: 20-40 parts of dendrobium, 1-10 parts of clove, 5-20 parts of pinellia tuber, 15-30 parts of Qianlicao, 30-50 parts of jasmine flower, 10-25 parts of bighead atractylodes rhizome, 6-18 parts of radix codonopsis pilosulae and 12-28 parts of honey-fried licorice root.
2. A method for preparing a traditional Chinese medicine composition for treating chronic atrophic gastritis as claimed in claim 1, comprising the following steps:
soaking herba Euphorbiae Humifusae, flos Jasmini sambac and radix Glycyrrhizae Preparata in 40-50deg.C water for 20-30min, and distilling to obtain volatile oil and residue I; pulverizing herba Dendrobii, flos Caryophylli, rhizoma Pinelliae, atractylodis rhizoma and radix Codonopsis, adding the first residue, soaking in ethanol for 20-50 hr, percolating to obtain percolate and second residue, and extracting the second residue with water under microwave to obtain extractive solution; mixing the extractive solution, the percolate and the volatile oil, concentrating, and drying.
3. The preparation method according to claim 2, wherein the extraction temperature is 70-90 ℃ and the extraction time is 30-50min during the distillation extraction.
4. The method according to claim 3, wherein the mass fraction of the ethanol is 60-75%, and the amount is 0.8-1.5 times the mass of the raw material.
5. The method according to claim 4, wherein the rate of percolation is 2.24-3.58mL/min.
6. The method according to claim 5, wherein the step of mixing the extract, the percolate and the volatile oil further comprises centrifuging at 800-1200r/min for 5-10min.
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Publication number Priority date Publication date Assignee Title
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