CN113576982A - Preparation method of multifunctional nano stone needle fiber mask capable of diminishing inflammation and whitening skin - Google Patents
Preparation method of multifunctional nano stone needle fiber mask capable of diminishing inflammation and whitening skin Download PDFInfo
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- CN113576982A CN113576982A CN202111025353.3A CN202111025353A CN113576982A CN 113576982 A CN113576982 A CN 113576982A CN 202111025353 A CN202111025353 A CN 202111025353A CN 113576982 A CN113576982 A CN 113576982A
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- stone needle
- whitening
- preparation
- wall
- radix tetrastigme
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61Q19/08—Anti-ageing preparations
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0069—Electro-spinning characterised by the electro-spinning apparatus characterised by the spinning section, e.g. capillary tube, protrusion or pin
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
- D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Abstract
The invention belongs to the field of preparation of a nano stone needle fiber membrane by electrostatic spinning, and particularly relates to a preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask. A preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask comprises the following specific steps: 1) dissolving organic alcohol and hyaluronic acid in deionized water, heating and stirring uniformly at 50-80 ℃ to obtain a spinning solution A; 2) adding stone needle powder, radix tetrastigme extract and whitening components into the spinning solution A, and uniformly stirring to obtain a mixed spinning solution B; 3) and (3) performing electrostatic spinning on the mixed spinning solution B, and collecting by using a collecting device to obtain the multifunctional nano stone needle fiber mask with the functions of moisturizing, moisturizing and whitening. The combination of the above three components is applied to the facial mask, so that the facial mask has multiple functions, and not only has the functions of whitening and removing acne, but also has the health-care function.
Description
Technical Field
The invention belongs to the field of preparation of a nano stone needle fiber membrane by electrostatic spinning, and particularly relates to a preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask.
Background
Beauty is the nature of human, and the key points are to keep skin white and diminish inflammation without acne. With the continuous improvement of living standard of people, the requirements of people on the skin of people are higher and higher, and more people spend time on the appearance. Nowadays, facial masks have been widely used as cosmetic products having a cosmetic effect on the skin of the face and the like. The principle of the facial mask is that a thick layer of dressing with different functions and components is applied to the face to prevent the skin from contacting with air. When the dressing is tightly attached to the skin, the temperature of the skin is raised due to the inhibition of sebum secretion and sweat evaporation; after the temperature of the skin rises, the blood circulation is promoted, and nutrients permeating into the skin are diffused deeper and wider among cells.
Electrospinning is a special fiber manufacturing process, where polymer solutions or melts are jet spun in a strong electric field. This way, polymer filaments of nanometer-scale diameter can be produced. Different from the polymer fiber prepared by the traditional method, the polymer nanofiber prepared by the electrostatic spinning method has the advantages of large specific surface area, high porosity, light weight and the like, and has potential application value in the fields of wound dressing, tissue engineering, drug carriers and the like. Electrospinning has been rarely studied in the area of facial masks.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a preparation method of an anti-inflammatory and whitening multifunctional nano stone needle fiber mask.
The technical purpose of the invention is realized by the following technical scheme:
a preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask comprises the following specific steps:
1) dissolving organic alcohol and hyaluronic acid in deionized water, heating and stirring uniformly at 50-80 ℃ to obtain a spinning solution A;
2) adding stone needle powder, radix tetrastigme extract and whitening components into the spinning solution A, and uniformly stirring to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, and collecting by using a collecting device to obtain the multifunctional nano stone needle fiber mask with the functions of moisturizing, moisturizing and whitening.
The stone needle has a singular energy field, can generate infrared rays and ultrasonic waves when acting on a human body and can run along the channels, and has the effects of balancing the pH value of the body, promoting blood circulation, improving sub-health, maintaining beauty and keeping young and preserving health; the radix tetrastigme is a traditional Chinese medicinal material and has the effects of clearing away heat and toxic materials, dispelling wind and eliminating phlegm, and activating blood and relieving pain, and the extract of the radix tetrastigme contains various medicinal active ingredients. The radix tetrastigme leaf contains active ingredients, organic acids, anthocyanins and other ingredients, and the radix tetrastigme extract is used in the facial mask to play a role in diminishing inflammation and removing acnes; the whitening component has effects of removing speckle, whitening skin, and inhibiting melanin. The combination of the above three components is applied to the facial mask, so that the facial mask has multiple functions, and not only has the functions of whitening and removing acne, but also has the health-care function.
Preferably, the organic alcohol in step 1) is one or a combination of ethylene glycol and glycerol.
Preferably, the mass fraction of the spinning solution a in the step 1) is 15-25%.
Preferably, the whitening component in step 2) is one or a combination of niacinamide, vitamin C, tartaric acid or kojic acid.
Preferably, the stone needle powder, the radix tetrastigme powder and the whitening component in the step 2) comprise the following components in parts by mass: 65-75% of stone needle powder, 18-30% of radix tetrastigme powder and 5-7% of whitening component.
Preferably, in the step 3), the flow rate of the electrostatic spinning is 0.2-1mL/h, the voltage is 15-20 kV, the receiving screen of the collecting device adopts facial mask paper for receiving, and the distance between the needle head and the receiving screen is 10-15 cm.
Preferably, a composite modified substance is added to the mixed spinning solution B, and the composite modified substance comprises, by mass, 1: 2-4, mixing the titanium dioxide and the nano silver;
the preparation method of the modified titanium dioxide comprises the following steps: adding tetrabutyl titanate into an ethanol solvent, uniformly stirring, and adding water and La (NO) according to the mass ratio of 1:0.1-0.2:3-4:0.05-0.083)3Adding dilute hydrochloric acid, adjusting the pH value to 5.5-6, heating the solution to 65-70 ℃, reacting for 3-4h until a gel is formed, standing and aging the gel material for 8-10h, removing the solvent, heating the solid product in a stepped manner for drying, heating the solid product to 280-350 ℃ in the first stage for 15-20/min, and preserving the heat for 1-2 h; the temperature rise rate of the second stage is 12-15 ℃/min, the temperature rises to 550 ℃ and 600 ℃, the heat preservation treatment is carried out for 2-3h, and the La-doped mesoporous titanium dioxide is obtained after crushing;
the preparation method of the modified nano silver comprises the following steps:
coating silicon dioxide coated nano silver Ag/SiO2Absolute ethyl alcohol is used for preparing 6 g/L-8 g/L solution; after being dispersed evenly, the modifier of thiocyanatopropyltriethoxysilane and nano-silver Ag/SiO are added2The mass ratio of the modifier to the modifier is 1: 1-5, the reaction temperature is 60-70 ℃, and the reaction time is 0.6-1 h; and (4) performing centrifugal separation, washing the centrifuged solid with ethyl ketone, filtering, drying and crushing to obtain the modified nano silver.
The composite modifier can be better dispersed and compatible with stone needles, has a photodecomposition effect and excellent antibacterial property and biological environmental protection property; thereby endowing the mask with better whitening effect and excellent health care performance.
Preferably, the electrostatic spinning device for preparing facial mask fibers comprises an electrostatic spinning machine body, an injection nozzle is fixedly installed at the top of the inner wall of the electrostatic spinning machine body, a fixed frame is fixedly installed at the bottom of the inner wall of the electrostatic spinning machine body through a bolt, a threaded hole is formed in one side of the inner wall of the fixed frame, a roller is contacted with the bottom of the inner wall of the electrostatic spinning machine body, a connecting frame is rotatably sleeved at the top of the outer wall of the roller, a motor is fixedly installed at the top of the connecting frame through the bolt, a rotating rod is welded at the output end of the motor, a positioning thread is formed in the outer wall of the rotating rod, which is close to the motor, the positioning thread is sleeved in the threaded hole, a rotating ring is fixedly sleeved at the middle of the outer wall of the electrostatic spinning machine body, a supporting frame is rotatably sleeved on the outer wall of the rotating ring, a cross rod is rotatably sleeved on one side of the inner wall of the supporting frame, a receiving roller is fixedly sleeved on the outer wall of the cross rod, the output end of the injection nozzle is opposite to the receiving roller, one end of the cross rod penetrates through the supporting frame, a second gear is fixedly sleeved on the outer wall of one end of the cross rod, a first gear is connected to the bottom of the second gear in a meshed mode, and the first gear is fixedly sleeved in the middle of the outer wall of the rotating rod.
According to the invention, the receiving roller on the support frame can be driven to move transversely under the limit of the threaded hole and the positioning thread through the positive and negative rotation of the motor, so that when the injection nozzle has a limit on the spinning injection range, the receiving roller is moved, the spinning gathering area on the receiving roller is larger, the mask cloth formed after solidification and gathering is also larger, the mask cloth with various sizes and specifications can be conveniently prepared, the whole machine is convenient and practical, and the machine is suitable for mass production. After the motor of the invention is operated, the receiving roller is driven to rotate by the components such as the rotating rod, the two gears and the like, so that the spinning is more uniformly distributed on the receiving roller during the electrostatic spinning, the formation of the mask cloth is convenient, the receiving roller can transversely move and rotate while being controlled by the motor, two motion states of the receiving roller can be completed by only one motor, and the practicability of the device is improved.
As a preferred technical scheme of the invention, one end of the rotating rod penetrates through the fixing frame, and the limiting rod is welded in the fixing frame.
As a preferred technical scheme of the invention, the bottom end of the support frame is slidably sleeved on the outer wall of the limiting rod, and the rotating ring and the first gear are both positioned right above the limiting rod.
As a preferable technical scheme of the invention, the bottom of the support frame is contacted with the bottom of the inner wall of the fixed frame, and the rotating ring is positioned between the positioning thread and the first gear.
As a preferred technical solution of the present invention, the receiving roller is located inside the supporting frame, and the second gear is located outside the supporting frame.
As a preferred technical scheme of the invention, the electrostatic spinning machine body and the motor are both electrically connected with an external power supply, the rotating ring is in a circular ring shape, and the fixing frame is in a U-shaped shape.
Preferably, the preparation method of the radix tetrastigme extract comprises the following steps:
(1) placing the dried radix tetrastigme in a tubular heating furnace for heating and wall breaking; heating the tubular heating furnace to 85-95 ℃ at the speed of 5-10 ℃/min, treating for 12-16min, and introducing nitrogen as a protective gas in the heating process;
(2) soaking the wall-broken radix tetrastigme in ethanol water solution to obtain radix tetrastigme ethanol mixed solution;
(3) placing the obtained radix tetrastigme ethanol mixed solution in a microwave extraction instrument for first leaching extraction for 70-90 seconds to obtain a first radix tetrastigme extracting solution; the frequency of the microwave extraction instrument is 1000-1500MHz, and the power is 850-950W;
(4) standing the first extracting solution for 5-10min, placing in a microwave extraction instrument, and performing second extraction for 180 seconds at 150-; the frequency of the microwave extraction instrument is 799-900MHz, and the power is 300-400W;
(5) standing the second extractive solution for 8-10min, and naturally cooling to room temperature; then placing the mixture into a centrifuge, and centrifugally separating and collecting supernatant;
(6) and distilling the supernatant under reduced pressure to obtain the radix tetrastigme extract, wherein the yield of total effective active ingredients in the radix tetrastigme extract is more than 3.35%.
The radix tetrastigme extract contains effective active ingredients of neochlorogenic acid, quercetin, kaempferol, catechin, kaempferol-3-0-rutinoside, astragalin, resveratrol, isovitexin, rutin and apigenin; the effective active ingredients in the radix tetrastigme have the effects of resisting bacteria, aging, oxidation, free radical removal, aging delay and the like, and are ideal natural sources for preparing anti-inflammatory acne-removing products.
Most of the existing wall breaking technologies need to be prepared into a radix tetrastigme aqueous solution, and wall breaking is performed on the basis, however, the wall breaking treatment has great influence on the subsequent extraction of effective active ingredients, because the solubility of the effective active ingredients in the aqueous solution is poor; according to the method, the wall of the radix tetrastigme is broken by adopting the tubular heating furnace, nitrogen is taken as protective gas, so that high-temperature oxidation of substances such as effective active ingredients and the like can be avoided, a stable environment is provided for the wall breaking of the radix tetrastigme by specific temperature rise rate, time and temperature control, and pollen can be uniformly and effectively heated for wall breaking; the subsequent microwave extraction further expands and breaks the walls of the cells of the radix tetrastigme powder, so that the effective active ingredients in the cells can be fully contacted with the solvent and then dissolved, the extraction efficiency can be greatly improved, and the yield of the total effective active ingredients is improved. Compared with the traditional microwave extraction method, the method adopts twice high-power microwave extraction and then low-power microwave extraction, adopts higher power and microwave frequency in the first stage, can further improve the extraction efficiency of the effective active ingredients in the quick extraction stage of the effective active ingredients, and adopts relatively lower power and microwave frequency in the second stage, so that the thermal degradation effect on the extracted effective active ingredients in the extracting solution can be reduced; the radix tetrastigme extract prepared by the method has better effects of promoting inflammation diminishing and acne removing; the radix tetrastigme extract is prepared by the microwave method, so that the extraction efficiency is high; the yield of the total effective active ingredients is high, the radix tetrastigme contains 3.36 percent of the total effective active ingredients, and the yield of the total effective active ingredients extracted by the method is 3.35 percent; the extraction of the invention is not only superior to the traditional microwave extraction method, but also superior to the existing soaking extraction and ultrasonic extraction methods.
More preferably, the pressure in the step (6) is 0.06-0.08MPa and the temperature is 80-90 ℃ when the reflux is heated under reduced pressure.
In conclusion, the invention has the following beneficial effects:
1. the stone needle has a singular energy field, can generate infrared rays and ultrasonic waves when acting on a human body and can run along the channels, and has the effects of balancing the pH value of the body, promoting blood circulation, improving sub-health, maintaining beauty and keeping young and preserving health; the radix tetrastigme is a traditional Chinese medicinal material and has the effects of clearing away heat and toxic materials, dispelling wind and eliminating phlegm, and activating blood and relieving pain, and the extract of the radix tetrastigme contains various medicinal active ingredients. The radix tetrastigme leaf contains active ingredients, organic acids, anthocyanins and other ingredients, and the radix tetrastigme extract is used in the facial mask to play a role in diminishing inflammation and removing acnes; the whitening component has effects of removing speckle, whitening skin, and inhibiting melanin. The combination of the three components is applied to the facial mask, so that the facial mask has multiple functions, and not only has the functions of whitening and removing acne, but also has the health-care function;
2. the radix tetrastigme extract is prepared by the microwave method, so that the extraction efficiency is high; the yield of the total effective active ingredients is high, the radix tetrastigme contains 3.36 percent of the total effective active ingredients, and the yield of the total effective active ingredients extracted by the method is 3.35 percent; the extraction of the invention is not only superior to the traditional microwave extraction method, but also superior to the existing soaking extraction and ultrasonic extraction methods;
3. the composite modifier can be better dispersed and compatible with stone needles, has a photodecomposition effect and excellent antibacterial property and biological environmental protection property; thereby endowing the mask with better whitening effect and excellent health care performance;
4. according to the electrostatic spinning device for preparing the facial mask fibers, the motor rotates forwards and backwards, the receiving roller on the supporting frame is driven to move transversely under the limit of the threaded hole and the positioning thread, so that when the injection nozzle limits the spraying range of the spinning, the receiving roller is moved, the spinning gathering area on the receiving roller is larger, the facial mask cloth formed after solidification and gathering is larger, the preparation of the facial mask cloth with various sizes and specifications is facilitated, the whole device is convenient and practical, and the device is suitable for mass production.
Drawings
FIG. 1 is an overall structural front view of an electrostatic spinning device for preparing facial mask fibers according to the present invention;
FIG. 2 is a front sectional view showing the overall structure of an electrostatic spinning apparatus for preparing facial mask fibers according to the present invention;
FIG. 3 is an enlarged view of the structure A of FIG. 2 according to the present invention;
FIG. 4 is an enlarged view of the structure B of FIG. 3 according to the present invention;
FIG. 5 is a front view of a swivel of an electrospinning apparatus for preparing facial mask fibers according to the present invention;
FIG. 6 is an SEM image of the multifunctional anti-inflammatory and whitening nano stone needle fiber mask of example 1;
FIG. 7 is an SEM image of the multifunctional anti-inflammatory and whitening nano stone needle fiber mask of example 2;
FIG. 8 is an SEM image of the multifunctional anti-inflammatory and whitening nano stone needle fiber mask of example 3.
In the drawings, the reference numbers: 1. an electrostatic spinning machine body; 11. an injection nozzle; 2. a fixed mount; 21. a threaded hole; 22. a limiting rod; 3. a roller; 31. a connecting frame; 32. a motor; 33. a rotating rod; 34. positioning the screw thread; 35. rotating the ring; 36. a first gear; 4. a support frame; 41. a cross bar; 42. a receiving roller; 43. a second gear.
Detailed Description
Example 1
A preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask comprises the following specific steps:
1) dissolving organic alcohol ethylene glycol or glycerol and hyaluronic acid in deionized water, heating and stirring uniformly at 50 ℃ to obtain 15% by mass of spinning solution A;
2) adding stone needle powder, radix tetrastigme extract and whitening component (one or combination of nicotinamide, vitamin C, tartaric acid or kojic acid) into the spinning solution A, wherein the mass fractions are as follows: stirring uniformly 65% of stone needle powder, 30% of radix tetrastigme powder and 5% of whitening component to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, wherein the flow rate of the electrostatic spinning is 0.2mL/h, the voltage is 15 kilovolts, the electrostatic spinning solution B is collected through a collecting device, a receiving screen of the collecting device is received by mask paper, and the distance between a needle head and the receiving screen is 10cm, so that the anti-inflammation and whitening multifunctional nano stone needle fiber mask capable of moisturizing and moisturizing is obtained.
Example 2
A preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask comprises the following specific steps:
1) dissolving organic alcohol ethylene glycol or glycerol and hyaluronic acid in deionized water, heating and stirring uniformly at 80 ℃ to obtain spinning solution A with the mass fraction of 25%;
2) adding stone needle powder, radix tetrastigme extract and whitening component (one or combination of nicotinamide, vitamin C, tartaric acid or kojic acid) into the spinning solution A, wherein the mass fractions are as follows: uniformly stirring 75% of stone needle powder, 18% of radix tetrastigme powder and 7% of whitening component to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, collecting the mixed spinning solution B through a collecting device, wherein the flow rate of the electrostatic spinning is 1mL/h, the voltage is 20 kilovolts, a receiving screen of the collecting device is received by mask paper, and the distance between a needle head and the receiving screen is 15cm, so that the multifunctional anti-inflammation and whitening nano stone needle fiber mask capable of moisturizing is obtained.
Example 3
A preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask comprises the following specific steps:
1) dissolving organic alcohol ethylene glycol or glycerol and hyaluronic acid in deionized water, heating and stirring uniformly at 70 ℃ to obtain a spinning solution A with the mass fraction of 20%;
2) adding stone needle powder, radix tetrastigme extract and whitening component (one or combination of nicotinamide, vitamin C, tartaric acid or kojic acid) into the spinning solution A, wherein the mass fractions are as follows: uniformly stirring 70% of stone needle powder, 24% of radix tetrastigme powder and 6% of whitening component to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, wherein the flow rate of the electrostatic spinning is 0.6mL/h, the voltage is 18 kilovolts, the electrostatic spinning is collected through a collecting device, a receiving screen of the collecting device is received by mask paper, and the distance between a needle head and the receiving screen is 12cm, so that the multifunctional anti-inflammatory and whitening nano stone needle fiber mask capable of moisturizing is obtained.
Example 4
Dissolving ethylene glycol and hyaluronic acid in deionized water, heating and uniformly stirring at 50 ℃ to obtain a spinning solution A, wherein the mass fraction of the spinning solution A is 15%; adding stone needle powder, radix tetrastigme powder and vitamin C into the spinning solution, and uniformly stirring to obtain a mixed spinning solution B, wherein the mass fraction of each component is as follows: 65% of stone needle powder, 30% of radix tetrastigme powder and 5% of vitamin C; and (2) performing electrostatic spinning on the mixed spinning solution, and collecting the mixed spinning solution through a collecting device to obtain the multifunctional nano stone needle fiber mask for diminishing inflammation and whitening, which is capable of moisturizing and moisturizing, wherein the electrostatic spinning process parameters are as follows: 15 kV, receiving distance 15cm, solution flow rate 0.5 mL/h.
Wherein, FIG. 1 is an SEM image of an anti-inflammatory whitening multifunctional nano stone needle fiber mask, and the fiber diameter is 100-150 nm.
The preparation method of the radix tetrastigme extract comprises the following steps:
(1) placing the dried folium Apioris Fortunei in a tubular heating furnace for heating and breaking cell wall; heating the tubular heating furnace to 85 ℃ at the speed of 5 ℃/min, treating for 12min, and introducing nitrogen as a protective gas in the heating process;
(2) soaking the wall-broken radix tetrastigme in ethanol water solution to obtain radix tetrastigme ethanol mixed solution;
(3) placing the obtained radix tetrastigme ethanol mixed solution in a microwave extraction instrument, and performing primary leaching extraction for 70 seconds to obtain a first radix tetrastigme extracting solution; the frequency of the microwave extraction instrument is 1000MHz, and the power is 850W;
(4) standing the first extractive solution for 5min, placing in a microwave extraction apparatus, and performing second extraction for 150 s to obtain second extractive solution of radix Apioris Fortunei; the frequency of the microwave extraction instrument is 700MHz, and the power is 300W;
(5) standing the second extractive solution for 8min, and naturally cooling to room temperature; then placing the mixture into a centrifuge, and centrifugally separating and collecting supernatant;
(6) and distilling the supernatant under reduced pressure to obtain the radix tetrastigme extract, wherein the yield of the total flavone in the radix tetrastigme extract is more than 3.35%.
Example 5
Dissolving glycerol and hyaluronic acid in deionized water, heating and stirring uniformly at 80 ℃ to obtain a spinning solution A, wherein the mass fraction of the spinning solution A is 20%; adding stone needle powder, radix tetrastigme powder and nicotinamide into the spinning solution, and uniformly stirring to obtain a mixed spinning solution B, wherein the mass fractions of the components are as follows: 70% of stone needle powder, 30% of radix tetrastigme powder and 5% of nicotinamide; and (2) performing electrostatic spinning on the mixed spinning solution, and collecting the mixed spinning solution through a collecting device to obtain the multifunctional nano stone needle fiber mask for diminishing inflammation and whitening, which is capable of moisturizing and moisturizing, wherein the electrostatic spinning process parameters are as follows: 15 kV, receiving distance 10cm, solution flow rate 0.2 mL/h. Wherein, FIG. 2 is an SEM image of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening, and the fiber diameter is 100-220 nm.
The preparation method of the radix tetrastigme extract comprises the following steps:
(1) placing the dried folium Apioris Fortunei in a tubular heating furnace for heating and breaking cell wall; heating the tubular heating furnace to 90 ℃ at the speed of 8 ℃/min, wherein the treatment time is 15min, and introducing nitrogen as a protective gas in the heating process;
(2) soaking the wall-broken radix tetrastigme in ethanol water solution to obtain radix tetrastigme ethanol mixed solution;
(3) placing the obtained radix tetrastigme ethanol mixed solution in a microwave extraction instrument, and performing primary leaching extraction for 80 seconds to obtain a first radix tetrastigme extracting solution; the frequency of the microwave extraction instrument is 1200MHz, and the power is 900W;
(4) standing the first extractive solution for 8min, placing in a microwave extraction apparatus, and performing second extraction for 170 s to obtain second extractive solution of radix Apioris Fortunei; the frequency of the microwave extraction instrument is 800MHz, and the power is 350W;
(5) standing the second extractive solution for 9min, and naturally cooling to room temperature; then placing the mixture into a centrifuge, and centrifugally separating and collecting supernatant;
(6) and distilling the supernatant under reduced pressure to obtain the radix tetrastigme extract, wherein the yield of the total flavone in the radix tetrastigme extract is more than 3.35%.
Example 6
Dissolving ethylene glycol and hyaluronic acid in deionized water, heating and stirring uniformly at 80 ℃ to obtain a spinning solution A, wherein the mass fraction of the spinning solution A is 25%; adding stone needle powder, radix tetrastigme powder and tartaric acid into the spinning solution, and uniformly stirring to obtain a mixed spinning solution B, wherein the mass fractions of the components are as follows: 75% of stone needle powder, 18% of radix tetrastigme powder and 7% of fruit acid; and (2) performing electrostatic spinning on the mixed spinning solution, and collecting the mixed spinning solution through a collecting device to obtain the multifunctional nano stone needle fiber mask for diminishing inflammation and whitening, which is capable of moisturizing and moisturizing, wherein the electrostatic spinning process parameters are as follows: 10 kV, receiving distance 15cm, solution flow rate 1 mL/h.
Wherein, FIG. 3 is an SEM image of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening, and the fiber diameter is 100-120 nm.
The preparation method of the radix tetrastigme extract comprises the following steps:
(1) placing the dried folium Apioris Fortunei in a tubular heating furnace for heating and breaking cell wall; heating the tubular heating furnace to 95 ℃ at the speed of 10 ℃/min, wherein the treatment time is 16min, and introducing nitrogen as a protective gas in the heating process;
(2) soaking the wall-broken radix tetrastigme in ethanol water solution to obtain radix tetrastigme ethanol mixed solution;
(3) placing the obtained radix tetrastigme ethanol mixed solution in a microwave extraction instrument, and performing first leaching extraction for 90 seconds to obtain a first radix tetrastigme extracting solution; the frequency of the microwave extraction instrument is 1500MHz, and the power is 950W;
(4) standing the first extract for 10min, placing in a microwave extraction apparatus, and performing second extraction for 180 s to obtain second extract of radix Apioris Fortunei; the frequency of the microwave extractor is 900MHz, and the power is 400W;
(5) standing the second extractive solution for 10min, and naturally cooling to room temperature; then placing the mixture into a centrifuge, and centrifugally separating and collecting supernatant;
(6) and distilling the supernatant under reduced pressure to obtain the radix tetrastigme extract, wherein the yield of the total flavone in the radix tetrastigme extract is more than 3.35%.
Example 7
The difference from the above embodiment 4 is that the electrostatic spinning device for preparing facial mask fibers of the present embodiment employs the electrostatic spinning device for preparing facial mask fibers shown in fig. 1 to 5:
an electrostatic spinning device for preparing facial mask fibers comprises an electrostatic spinning machine body 1, wherein the electrostatic spinning machine body 1 is an existing electrostatic spinning machine, internal mechanisms of the electrostatic spinning machine body 1 are disclosed, and redundant description is omitted, an injection nozzle 11 is fixedly installed at the top of the inner wall of the electrostatic spinning machine body 1, so that electrostatic spinning spraying can be conveniently carried out by using the injection nozzle 11, a fixing frame 2 is fixedly installed at the bottom of the inner wall of the electrostatic spinning machine body 1 through bolts, the electrostatic spinning machine body 1 can conveniently fix the fixing frame 2, and a threaded hole 21 is formed in one side of the inner wall of the fixing frame 2;
the bottom of the inner wall of the electrostatic spinning machine body 1 is contacted with the roller 3, the electrostatic spinning machine body 1 can support the roller 3, the top of the outer wall of the roller 3 is rotatably sleeved with the connecting frame 31, the connecting frame 31 can limit the roller 3, the top of the connecting frame 31 is fixedly provided with the motor 32 through bolts, the connecting frame 31 can support the motor 32, when the motor 32 moves transversely, the connecting frame 31 and the roller 3 can improve the stability of the motor 32 when moving, the roller 3 can reduce the resistance of the motor 32 when moving through rolling, the output end of the motor 32 is welded with the rotating rod 33, the motor 32 can drive the rotating rod 33 to rotate after running, and the motor 32 can rotate forwards and backwards, which is the prior art and is not described in more detail herein;
the outer wall of one end of the rotating rod 33 close to the motor 32 is provided with a positioning thread 34, the positioning thread 34 is in threaded sleeve in the threaded hole 21, one end of the rotating rod 33 is in threaded sleeve in the threaded hole 21 through the positioning thread 34, the positioning thread 34 and the threaded hole 21 are convenient for supporting and limiting the rotating rod 33, the middle part of the outer wall of the electrostatic spinning machine body 1 is fixedly sleeved with a rotating ring 35, the outer wall of the rotating ring 35 is rotatably sleeved with a support frame 4, the rotating ring 35 can be used for connecting the rotating rod 33 with the support frame 4, the rotating rod 33 is matched with a limiting rod 22 to limit the support frame 4, the support frame 4 can move transversely along with the rotating rod 33 and cannot rotate along with the rotating rod 33, one side of the inner wall of the support frame 4 is rotatably sleeved with a cross rod 41, the outer wall of the cross rod 41 is fixedly sleeved with a receiving roller 42, the cross rod 41 can support the receiving roller 42, the output end of the injection nozzle 11 is opposite to the receiving roller 42, and is convenient for the injection nozzle 11 to spray spinning on the receiving roller 42, support frame 4 is run through to horizontal pole 41 one end, and the fixed cover of horizontal pole 41 one end outer wall has second gear 43 for second gear 42 can drive horizontal pole 41 after rotating and rotate, and second gear 43 bottom meshing is connected with first gear 36, makes first gear 36 can drive second gear 43 after rotating and rotate, and first gear 36 is fixed to be overlapped in bull stick 33 outer wall middle part, and the bull stick 33 of being convenient for drives first gear 36 after rotating and rotates.
Specifically, referring to fig. 3, one end of the rotating rod 33 penetrates through the fixing frame 2, so that the fixing frame 2 can support the rotating rod 33, and the limiting rod 22 is welded in the fixing frame 2, thereby facilitating the fixing frame 2 to support the limiting rod 22.
Specifically, referring to fig. 3, the bottom end of the supporting frame 4 is slidably sleeved on the outer wall of the limiting rod 22, so that the limiting rod 22 can limit the supporting frame 4, the supporting frame 4 can only move laterally but cannot rotate, and the rotating ring 35 and the first gear 36 are both located right above the limiting rod 22.
Specifically, referring to fig. 3, the bottom of the supporting frame 4 is in contact with the bottom of the inner wall of the fixing frame 2, so that the fixing frame 2 can limit and support the supporting frame 4, and the rotating ring 35 is located between the positioning thread 34 and the first gear 36.
Specifically, referring to fig. 3, the receiving roller 42 is located inside the supporting frame 4, so that the supporting frame 4 can shield and protect the receiving roller 42, the second gear 43 is located outside the supporting frame 4, and the second gear 42 rotates outside the supporting frame 4.
Specifically, referring to fig. 1, 3 and 5, the electrostatic spinning machine body 1 and the motor 32 are electrically connected to an external power supply, the external power supply supplies power, the rotating ring 35 is in a circular ring shape, so that the rotating ring 35 can rotate in the supporting frame 4 conveniently, and the fixing frame 2 is in a U-shape, so that the fixing frame 2 can support the rotating rod 33 conveniently.
The working principle is as follows: when in use, the motor 32 is controlled to rotate positively and negatively, the motor 32 drives the rotating rod 33 to rotate after running, at the moment, under the supporting and limiting of the threaded hole 21 and the positioning thread 34 on the rotating rod 33, the rotating rod 33 rotates and moves transversely (communicated with a rotating bolt principle), so that the motor 32, the support frame 4 and the rotating rod 33 are driven to move transversely integrally, meanwhile, under the limiting of the rotating ring 35 and the limiting rod 22, the support frame 4 can only move transversely but not rotate, because the position of the injection nozzle 11 is fixed and the injection range is fixed, the transverse movement of the support frame 4 and the receiving roller 42 can be utilized to increase the spinning gathering area on the receiving roller 42, so that the preparation of facial mask cloths with various sizes and specifications can be conveniently carried out, meanwhile, after the rotating rod 33 rotates, the transverse rod 41 can be driven to rotate by the first gear 36 and the second gear 43, the transverse rod 41 can drive the receiving roller 42 to rotate in the support frame 4, during electrostatic spinning, the receiving roller 42 is rotated, so that the spray spinning is more uniformly distributed on the receiving roller 42, the mask cloth is convenient to form, the connecting frame 31 and the roller 3 can support the motor 32, and the motor 32 is more stable in operation and movement.
Example 8
The difference from example 5 is that the electrospinning apparatus of this example is the same as example 7.
Example 9
The difference from example 6 is that the electrospinning apparatus of this example is the same as example 7.
Example 10
The same as example 7, except that the dispersion liquid in the step (1) is added with a composite modifier, and the composite modifier comprises the following components in a mass ratio of 1: 2, mixing the titanium dioxide and the nano silver;
the preparation method of the modified titanium dioxide comprises the following steps: adding tetrabutyl titanate into an ethanol solvent, uniformly stirring, and adding water and La (NO) according to the mass ratio of 1:0.1:3:0.053)3Adding dilute hydrochloric acid, adjusting the pH value to 5.5, heating the solution to 65 ℃, reacting for 3 hours until a gel is formed, standing and aging the gel material for 8 hours, removing the solvent, heating the solid product in a stepped manner and drying, heating to 280 ℃ in a first stage for 15/min, and keeping the temperature for 1 hour; the temperature rise rate of the second stage is 12 ℃/min, the temperature is raised to 550 ℃, the heat preservation treatment is carried out for 2h, and the La-doped mesoporous titanium dioxide is obtained after crushing;
the preparation method of the modified nano silver comprises the following steps:
coating silicon dioxide coated nano silver Ag/SiO2Absolute ethyl alcohol is used for preparing a solution with the concentration of 6 g/L; after being dispersed evenly, the modifier of thiocyanatopropyltriethoxysilane and nano-silver Ag/SiO are added2The mass ratio of the modifier to the modifier is 1: 1, reaction temperatureThe reaction time is 0.6h at 60 ℃; and (4) performing centrifugal separation, washing the centrifuged solid with ethyl ketone, filtering, drying and crushing to obtain the modified nano silver.
Example 11
The same as example 8, except that the dispersion liquid in the step (1) is added with a composite modifier, and the composite modifier comprises the following components in a mass ratio of 1: 4, mixing the modified titanium dioxide and the modified nano silver;
the preparation method of the modified titanium dioxide comprises the following steps: adding tetrabutyl titanate into an ethanol solvent, uniformly stirring, and adding water and La (NO) according to the mass ratio of 1:0.2:4:0.083)3Adding dilute hydrochloric acid, adjusting the pH value to 6, heating the solution to 70 ℃, reacting for 4 hours until a gel is formed, standing and aging the gel material for 10 hours, removing the solvent, heating the solid product in a stepped manner and drying, heating to 350 ℃ in a first stage for 20/min, and keeping the temperature for 2 hours; the temperature rise rate of the second stage is 15 ℃/min, the temperature rises to 550 ℃ and 600 ℃, the heat preservation treatment is carried out for 3h, and the La-doped mesoporous titanium dioxide is obtained after crushing;
the preparation method of the modified nano silver comprises the following steps:
coating silicon dioxide coated nano silver Ag/SiO2Preparing 8g/L solution by using absolute ethyl alcohol; after being dispersed evenly, the modifier of thiocyanatopropyltriethoxysilane and nano-silver Ag/SiO are added2The mass ratio of the modifier to the modifier is 1: 5, the reaction temperature is 70 ℃, and the reaction time is 1 h; and (4) performing centrifugal separation, washing the centrifuged solid with ethyl ketone, filtering, drying and crushing to obtain the modified nano silver.
Example 12
The same as example 9, except that the dispersion liquid in the step (1) is added with a composite modifier, and the composite modifier comprises the following components in a mass ratio of 1: 2-4, mixing the titanium dioxide and the nano silver;
the preparation method of the modified titanium dioxide comprises the following steps: adding tetrabutyl titanate into an ethanol solvent, uniformly stirring, and adding water and La (NO) according to the mass ratio of 1:0.12:3.5:0.073)3N, N, N-trimethyl-1-hexadecylammonium bromide and polyethyleneAdding glycol, then adding dilute hydrochloric acid, adjusting the pH value to 6, heating the solution to 68 ℃, reacting for 3.4 hours until gel is formed, standing and aging the gel material for 9 hours, removing the solvent, heating the solid product in a stepped manner, drying, heating to 300 ℃ at the first stage for 18/min, and keeping the temperature for 1.5 hours; the temperature rise rate of the second stage is 14 ℃/min, the temperature is raised to 580 ℃, the heat preservation treatment is carried out for 2.5h, and the La-doped mesoporous titanium dioxide is obtained after crushing;
the preparation method of the modified nano silver comprises the following steps:
coating silicon dioxide coated nano silver Ag/SiO2Preparing 7g/L solution by using absolute ethyl alcohol; after being dispersed evenly, the modifier of thiocyanatopropyltriethoxysilane and nano-silver Ag/SiO are added2The mass ratio of the modifier to the modifier is 1:3, the reaction temperature is 65 ℃, and the reaction time is 0.8 h; and (4) performing centrifugal separation, washing the centrifuged solid with ethyl ketone, filtering, drying and crushing to obtain the modified nano silver.
Comparative example 1
The same as example 1, except that the organic alcohol and the hyaluronic acid are dissolved in deionized water, heated and stirred uniformly at 85 ℃ to obtain a spinning solution A;
2) adding stone needle powder, radix tetrastigme extract and whitening components into the spinning solution A, and uniformly stirring to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, and collecting by using a collecting device to obtain the multifunctional nano stone needle fiber mask with the functions of moisturizing, moisturizing and whitening.
Comparative example 2
The same as example 2, except that the spinning dope B did not contain the extract of Hevea hemsleyana.
The anti-inflammatory acne-removing, antibacterial and whitening effects of the mask product are tested in an experiment, and the anti-inflammatory acne-removing, antibacterial and whitening effects are as follows:
respectively selecting 40 people (20 people for each man and woman) with face having pox problem in three age groups of 15-25, 26-35 and 35-45, and continuously using for more than 30 days. The recording effect is divided into five grades: the traditional Chinese medicine composition has the advantages of obvious effect (acne disappears, skin becomes white and tender), good effect (acne is greatly improved, skin becomes white and tender), general effect (acne is slightly improved), no effect (no change) and adverse effect (acne aggravation).
The results are shown in tables 1, 2 and 3:
TABLE 1
TABLE 2
TABLE 3
The above experimental data illustrate that:
1. compared with the facial mask prepared by different formulas or different reaction temperatures in comparative examples, the facial mask prepared by adopting the specific formula and the preparation method in the embodiments 1-12 has better whitening, acne eliminating and antibacterial effects;
2. compared with the facial mask prepared in the embodiment 1-3, the facial mask prepared by the radix tetrastigme extract extracted by the specific preparation process of the radix tetrastigme extract in the embodiment 4-6 has better whitening, acne eliminating and antibacterial effects;
3. the facial mask prepared by the electrostatic spinning device for preparing facial mask fibers of the specific facial mask in the embodiments 7 to 9 is better in performance effect compared with the facial mask prepared by the common spinning device in the embodiments 1 to 6;
4. the facial mask prepared by the specific compound modified additive in the embodiment 10-12 of the invention has better antibacterial property and whitening effect compared with the facial mask prepared in the embodiment 1-9.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (10)
1. A preparation method of an anti-inflammation and whitening multifunctional nano stone needle fiber mask is characterized by comprising the following specific steps:
1) dissolving organic alcohol and hyaluronic acid in deionized water, heating and stirring uniformly at 50-80 ℃ to obtain a spinning solution A;
2) adding stone needle powder, radix tetrastigme extract and whitening components into the spinning solution A, and uniformly stirring to obtain a mixed spinning solution B;
3) and (3) performing electrostatic spinning on the mixed spinning solution B, and collecting by using a collecting device to obtain the multifunctional nano stone needle fiber mask with the functions of moisturizing, moisturizing and whitening.
2. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 1 is characterized in that: the organic alcohol in the step 1) is one or the combination of ethylene glycol and glycerol; the mass fraction of the spinning solution A in the step 1) is 15-25%.
3. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 2 is characterized in that: the whitening component in the step 2) is one or the combination of niacinamide, vitamin C, tartaric acid or kojic acid.
4. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 3 is characterized by comprising the following steps of: the stone needle powder, the radix tetrastigme powder and the whitening component in the step 2) comprise the following components in parts by mass: 65-75% of stone needle powder, 18-30% of radix tetrastigme powder and 5-7% of whitening component.
5. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 4 is characterized in that: in the step 3), the flow rate of the electrostatic spinning is 0.2-1mL/h, the voltage is 15-20 kilovolts, the receiving screen of the collecting device adopts facial mask paper for receiving, and the distance between the needle head and the receiving screen is 10-15 cm.
6. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 5 is characterized in that: the mixed spinning solution B is added with a composite modifier, and the composite modifier comprises the following components in a mass ratio of 1: 2-4, mixing the titanium dioxide and the nano silver;
the preparation method of the modified titanium dioxide comprises the following steps: adding tetrabutyl titanate into an ethanol solvent, uniformly stirring, and adding water and La (NO) according to the mass ratio of 1:0.1-0.2:3-4:0.05-0.083)3Adding dilute hydrochloric acid, adjusting the pH value to 5.5-6, heating the solution to 65-70 ℃, reacting for 3-4h until a gel is formed, standing and aging the gel material for 8-10h, removing the solvent, heating the solid product in a stepped manner for drying, heating the solid product to 280-350 ℃ in the first stage for 15-20/min, and preserving the heat for 1-2 h; the temperature rise rate of the second stage is 12-15 ℃/min, the temperature rises to 550 ℃ and 600 ℃, the heat preservation treatment is carried out for 2-3h, and the La-doped mesoporous titanium dioxide is obtained after crushing;
the preparation method of the modified nano silver comprises the following steps:
coating silicon dioxide coated nano silver Ag/SiO2Absolute ethyl alcohol is used for preparing 6 g/L-8 g/L solution; after being dispersed evenly, the modifier of thiocyanatopropyltriethoxysilane and nano-silver Ag/SiO are added2The mass ratio of the modifier to the modifier is 1: 1-5, the reaction temperature is 60-70 ℃, and the reaction time is 0.6-1 h; and (4) performing centrifugal separation, washing the centrifuged solid with ethyl ketone, filtering, drying and crushing to obtain the modified nano silver.
7. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 6 is characterized in that: the preparation method of the radix tetrastigme extract comprises the following steps:
(1) placing the dried radix tetrastigme in a tubular heating furnace for heating and wall breaking; heating the tubular heating furnace to 85-95 ℃ at the speed of 5-10 ℃/min, treating for 12-16min, and introducing nitrogen as a protective gas in the heating process;
(2) soaking the wall-broken radix tetrastigme in ethanol water solution to obtain radix tetrastigme ethanol mixed solution;
(3) placing the obtained radix tetrastigme ethanol mixed solution in a microwave extraction instrument for first leaching extraction for 70-90 seconds to obtain a first radix tetrastigme extracting solution; the frequency of the microwave extraction instrument is 1000-1500MHz, and the power is 850-950W;
(4) standing the first extracting solution for 5-10min, placing in a microwave extraction instrument, and performing second extraction for 180 seconds at 150-; the frequency of the microwave extraction instrument is 799-900MHz, and the power is 300-400W;
(5) standing the second extractive solution for 8-10min, and naturally cooling to room temperature; then placing the mixture into a centrifuge, and centrifugally separating and collecting supernatant;
(6) and distilling the supernatant under reduced pressure to obtain the radix tetrastigme extract, wherein the yield of total effective active ingredients in the radix tetrastigme extract is more than 3.35%.
8. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 7 is characterized in that: in the step (6), the pressure is 0.06-0.08MPa and the temperature is 80-90 ℃ when the pressure is reduced, the heating and the refluxing are carried out.
9. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to any one of claims 1 to 8 is characterized in that: the electrostatic spinning device for preparing the facial mask fibers comprises an electrostatic spinning machine body (1), an injection nozzle (11) is fixedly mounted at the top of the inner wall of the electrostatic spinning machine body (1), a fixing frame (2) is fixedly mounted at the bottom of the inner wall of the electrostatic spinning machine body (1) through a bolt, a threaded hole (21) is formed in one side of the inner wall of the fixing frame (2), a roller (3) is contacted with the bottom of the inner wall of the electrostatic spinning machine body (1), a connecting frame (31) is rotatably sleeved at the top of the outer wall of the roller (3), a motor (32) is fixedly mounted at the top of the connecting frame (31) through a bolt, a rotating rod (33) is welded at the output end of the motor (32), a positioning thread (34) is formed in the outer wall of one end, close to the motor (32), of the positioning thread (34) is sleeved in the threaded hole (21), a rotating ring (35) is fixedly sleeved in the middle of the outer wall of the electrostatic spinning machine body (1), the utility model discloses a syringe, including swivel (35) outer wall, support frame (4), horizontal pole (41) outer wall fixed cover, injection shower nozzle (11) output is just to receiving roller (42), support frame (41) one end runs through support frame (4), horizontal pole (41) one end outer wall fixed cover has second gear (43), second gear (43) bottom meshing is connected with first gear (36), first gear (36) fixed cover is in bull stick (33) outer wall middle part.
10. The preparation method of the multifunctional nanometer stone needle fiber mask for diminishing inflammation and whitening according to claim 9 is characterized in that: one end of the rotating rod (33) penetrates through the fixing frame (2), and a limiting rod (22) is welded in the fixing frame (2);
the bottom end of the support frame (4) is slidably sleeved on the outer wall of the limiting rod (22), and the rotating ring (35) and the first gear (36) are both positioned right above the limiting rod (22);
the bottom of the support frame (4) is contacted with the bottom of the inner wall of the fixed frame (2), and the rotating ring (35) is positioned between the positioning thread (34) and the first gear (36).
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| CN117431645A (en) * | 2023-12-14 | 2024-01-23 | 福建省银河服饰有限公司 | Stone needle nanofiber preparation device and method |
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