CN109568173A - It is a kind of using hyaluronic acid as the instant facial mask of collagen nanometer and preparation method of skeleton - Google Patents
It is a kind of using hyaluronic acid as the instant facial mask of collagen nanometer and preparation method of skeleton Download PDFInfo
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- CN109568173A CN109568173A CN201910052945.0A CN201910052945A CN109568173A CN 109568173 A CN109568173 A CN 109568173A CN 201910052945 A CN201910052945 A CN 201910052945A CN 109568173 A CN109568173 A CN 109568173A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses a kind of using hyaluronic acid as instant facial mask of collagen nanometer of skeleton and preparation method thereof, the facial mask includes non-woven fabrics base material layer and layers of nanofibers, wherein, layers of nanofibers is formed on the non-woven fabrics base material layer using the method for electrostatic spinning, which includes: the surface reactive material of the Sodium Hyaluronate of 10-35 parts by weight, the Hydrolyzed Collagen of 6-50 parts by weight and 0.1-5 parts by weight；Wherein, the average molecular weight of Sodium Hyaluronate used is between 20000-60000, and the average molecular weight of Hydrolyzed Collagen used is between 1000-3000；The mass ratio of Sodium Hyaluronate and Hydrolyzed Collagen used used is between 1:5 to 6:1.
Description
Technical field
The present invention relates to a kind of facial masks and preparation method thereof, more particularly, it relates to which one kind is with hyaluronic acid
The instant facial mask of collagen nanometer and preparation method of skeleton.
Background technique
In Cosmetic Market, the mask product for personal nursing mostly uses greatly the shape that Essence is relied on to non-woven fabrics
Formula, but such product has that Essence is easy to be lost, inconvenient for use, availability is not high and longer etc. using the time when in use
Disadvantage, meanwhile, the ability of the Transdermal absorption of the active material in this kind of facial mask is uncertain, and more active active material exists easy
It is denaturalized, is difficult to the shortcomings that saving.People are always continually developing novel facial mask, to meet the continually changing consumption demand in market.
For example, Chinese patent 201310366143.X discloses a kind of composite nano-fiber membrane and preparation method thereof and answers
With comprising any one of polyvinyl alcohol, polylactic acid, regenerated silk fibroin: (1) being dissolved in organic solvent by following steps,
It is configured to the spinning solution that mass fraction is 5-20%；(2) polyatomic phenol substance is added in above-mentioned spinning solution, is uniformly mixing to obtain
The blend spinning liquid of the 1-7% of the polyatomic phenol substance and the organic solvent gross mass is accounted for, the polyatomic phenol substance is
One of vegatable tannin, apple polyphenol, vine polyphenol are a variety of；(3) by the blend spinning liquid ultrasonication 1-
600min；(4) it by the blend spinning liquid electrostatic spinning, collects, required composite nano-fiber membrane is made.But the spinning of the patent
Silk liquid is prepared by organic solvent, and more environmental issue can be brought.
Chinese patent application 201310403704.9 discloses a kind of nanofiber facial masks for whitening faces and removing spots patch comprising spinning
Solution and cotton, the active constituent of spinning solution are reduced glutathione and anti-oxidant auxiliary material, and mass ratio is reduced form paddy
The sweet peptide of Guang: anti-oxidant auxiliary material=1-10.The whitening spot-removing effective component of this application is reduced glutathione (GSH) and anti-oxidant
Auxiliary material, wherein GSH is scattered in nanofiber in the form of nano particle, and anti-oxidant auxiliary material can maintain the active group in GSH
Sulfydryl (- SH) is in reducing condition.The macromolecule that this application forms nanofiber is preferably polyvinyl alcohol, polyvinylpyrrolidine
One or more of ketone, water soluble chitosan, polyoxyethylene, wheat gluten, starch, gelatin, hyaluronic acid, are used
Solvent be preferably formic acid, acetic acid, acetone, methanol, ethyl alcohol, methylene chloride, chloroform, dimethylformamide, tetrahydrofuran, trifluoro
The mixing of one or more of acetic acid, hexafluoro -2- propyl alcohol.Similarly, compared with organic solvent or other electrodeless solvents,
Water is only most environmentally friendly, the cheapest solvent of cost, but this application preferably uses organic solvent.
Chinese patent application 201510684960.9 discloses a kind of collagen anti-ageing face mask comprising collagen
Face mask substrate material, peeling layer, anti-aging essence maceration extract, wherein collagen protein face substrate is made by following methods: (1) will freeze
The dry collagen powder of knot disperses that polymer solution is made in solution, and the temperature and humidity of polymer solution are interior
Condition；(2) by method of electrostatic spinning, the polymer solution of production makes layers of nanofibers by injection head under the action of electrostatic
Side is uniformly covered with collagen；(3) the collagen fabric layer of step (2) is placed in full of penta that mass fraction is 25%
12-24h makes collagen and layers of nanofibers crosslink reaction in the drier for the steam that dialdehyde aqueous solution generates, mutually product
Layer；(4) glutaraldehyde complete using unreacted in glycine removal sample, rises and falls to lamination by face contour and in muzzle eye phase
Corresponding position is cut, and facial mask is manufactured.But the facial mask of this application still falls within wet type facial mask, inconvenient for use.
Chinese patent application 201810371233.0 discloses a kind of so-called disposable hypersorption type nanofiber functional surfaces
Film and preparation method thereof, the facial mask is by following weight proportion at being grouped as: the polysaccharide of 5%-50% mass fraction, modification are more
Sugar, water soluble polymer, polymer substance of the 1%-10% with white-skinned face function, 0.001%-5% functional materials,
0.02%-2% Essence, surplus are water.The nanofiber functional mask of the patent application, with water-soluble modified polysaccharide or high score
Son is major solute, using various functional materials as additive, carries out mass production using electrostatic spinning technique.But it should
Although patent application loosely refers to, polysaccharide, modification of polysaccharides, water soluble polymer are gelatin, gelatine, carragheen, carboxymethyl fibre
Tie up element, methylcellulose, ethyl cellulose, hydroxyethyl cellulose, Sodium Hyaluronate, sodium alginate, polyethylene glycol, polyacrylamide
One of amine is a variety of, but does not disclose how using these substances, and easily occur in electrostatic spinning conglomeration, node,
Phenomena such as fracture of wire, hole, to seriously affect the performance of facial mask.The embodiment of the patent application then only refers to " respectively by 5%-
Polysaccharide, modification of polysaccharides, water soluble polymer such as polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP) of 50% mass fraction etc.
It is added to the water ".
Chinese patent application 201810053724.0 discloses a kind of preparation method based on nanofiber dry type facial mask,
Preparation including polyvinyl alcohol water solution, chitosan aqueous solution, sodium hyaluronate solution and nutrient solution；Product is prepared by above-mentioned
Mixing as spinning solution carry out Multi needle electrostatic spinning, use facial mask to use non-woven fabrics base material as receiving screen, finally facial mask without
One layer of nano fibrous membrane is formed on woven fabric substrate, and composite cellulosic membrane is made；70-80 DEG C drying 2-5 minutes；Cutting shapes, is close
Package dress and sterilizing are to get dry type facial mask.Effective component in facial mask liquid is mixed into polyvinyl alcohol spinning base fluid by the present invention,
Nanofiber will be prepared by electrostatic spinning technique and will be fixed in mask nonwoven fabric, and when use takes out facial mask, in front
Spray suitable pure water, make facial mask be sufficiently humidified so as to can face apply.
Chinese patent application 201811020688.4 discloses a kind of preparation method of solid-state facial mask, including on non-woven fabrics
Aqueous gel is brushed, then non-woven fabrics is dried, active ingredients are uniformly coated on non-woven fabrics by electrostatic spraying gun, often
The weight of the active constituent of gram non-woven fabrics absorption is 0.01~0.3 gram, is finally cut into the non-woven fabrics handled well according to face
Facial mask.
However, in the prior art when using electrospun nanofibers, on the one hand, the nanofiber of formation easily goes out
It phenomena such as existing conglomeration, node, fracture of wire, hole, seriously affected the structure of nanofiber, reduced the care benefits of facial mask, separately
On the one hand, nutritional ingredient added by spinning solution usually influences the formation of spinning fibre again, and the solvent selection of spinning solution also passes through
Often ignore environmental issue.
Thus, it is necessary to a kind of novel dry type facial mask is provided, to overcome shortcoming and defect existing in the prior art.
Summary of the invention
The object of the present invention is to provide a kind of nanofibers to be evenly distributed, without using the dry type facial mask and its system of organic solvent
Preparation Method, while layers of nanofibers in the facial mask is quickly dissolving plays a role.
On the one hand, in order to realize above-mentioned goal of the invention, the present invention provides a kind of using hyaluronic acid as the collagen of skeleton
The instant facial mask of nanometer, the facial mask include non-woven fabrics base material layer and layers of nanofibers, and layers of nanofibers therein is using Static Spinning
The method of silk is formed on non-woven fabrics base material layer, which includes:
The Sodium Hyaluronate of 1-30 parts by weight
The Hydrolyzed Collagen of 5-50 parts by weight；And
The surface reactive material of 0.1-5 parts by weight；
Wherein, the average molecular weight of Sodium Hyaluronate used is between 30000-60000, preferably in 25000-50000
Between；The average molecular weight of Hydrolyzed Collagen used is between 1000-3000, preferably between 1500-2500, such as
Between 1800-2300；Moreover, the mass ratio of Sodium Hyaluronate used and Hydrolyzed Collagen used 1:5 to 6:1 it
Between, preferably between 1:3 to 3:1.
Preferably, the layers of nanofibers of above-mentioned facial mask includes:
The Sodium Hyaluronate of 3-20 parts by weight
The Hydrolyzed Collagen of 6-30 parts by weight；And
The surface reactive material of 0.5-3 parts by weight.
In above-mentioned facial mask, Sodium Hyaluronate had not only formed the skeleton of nanofiber, but also had skin care activity；Hydrolysis used
Collagen is the Hydrolyzed Collagen of low molecular weight, and main function is to play the role of skin care actives；Low molecular weight
Hydrolyzed Collagen, the active function of skin care is much higher than the Hydrolyzed Collagen of high molecular weight.Certainly, low molecular weight is crossed
Hydrolyzed Collagen, and will affect electrostatic spinning.
In above-mentioned facial mask, the main function of used surface reactive material is to reduce surface tension, not arbitrarily
Surfactant is suitable for the present invention；Surface reactive material of the invention should be it is water-soluble, to skin nursing without bad
The surface reactive material of influence, and the surface reactive material would not influence electrostatic spinning and form uniform fiber.That is, at this
In invention, as long as surface reactive material water-soluble, with certain skin nursing effect, conducive to electrostatic spinning,
For the present invention.
Specifically, in facial mask of the invention, used surface reactive material can be with are as follows: polyoxyethylene sorbitan ester
Class emulsifier, such as polysorbate -20, polysorbate -60, Polyoxyethylene Sorbitan Monooleate etc.；Sucrose ester emulsifier, such as
Surfhope SE Cosme C 1216, sucrose stearate；Polyglycereol class emulsifier, such as Natrulon H-10 myristinate, -6 octanoic acid of polyglycereol
Ester, -6 stearate of polyglycereol etc.；Glycoside emulsifier, such as coco-glucosides, lauryl glucoside etc.；Polyethers or polyethers
Ester emulsifying agent, such as Cremophor RH40, PEG-20 methyl sesquistearate etc.；Etc..
Electrostatic spinning technique of the present invention refers to that Polymer Solution overcomes surface tension under high-pressure electrostatic effect,
Taylor (Taylor) cone is formed in spinning nozzle, and high speed sprays exit flow, volatilizees through mechanical stretch and solvent, and is formed by curing and receives
A kind of constructing technology of rice fibre structure.
Layers of nanofibers in facial mask of the present invention is that the water soluble polymers such as Sodium Hyaluronate is used to pass through electrostatic for matrix
Spining technology and produce, by diametrically there was only several hundred nanometers of fibroplastic nonwoven fabric from filaments, with large specific surface area, fibre
The advantages that continuity is good, fiber membrane aperture is small, porosity is high is tieed up, has good effect to active matter sustained release and protection, and be easy to
Skin permeation cuticula reaches deep skin, plays the functions such as moisturizing, whitening, delaying aging.
Since facial mask of the invention is a kind of stemness facial mask, it is easy to carry about with one and saves, it is easy to use, it only need to be with pure when use
Water purification or by spraying equal products elder generation wet skin, then apply the instant facial mask of nanometer again, and interior nanometer facial mask is just by completely molten in several seconds
It solves and is pasted on skin and play a role, without cleaning after, skin can be made to keep the compact sense and moisturizing degree of a few hours.
In order to form uniform spinning, prevent clustering phenomena occur during electrostatic spinning, it is preferable that in this hair
In bright facial mask, layers of nanofibers further comprises: the Fructus Hordei Germinatus oligose glucoside and 0.1-15 weight of 0.1-20 parts by weight
The hydrogenated starch hydrolysate of part, preferably the Fructus Hordei Germinatus oligose glucoside of 2-10 parts by weight and the hydrogenated starch water of 1-6 parts by weight
Solve object.In addition, the use of Fructus Hordei Germinatus oligose glucoside and hydrogenated starch hydrolysate, the user that can improve facial mask of the present invention uses shape
Condition prevents from generating stranding mud phenomenon on the face.In the layers of nanofibers of facial mask of the present invention, if used Fructus Hordei Germinatus oligose glucose
The accounting of glycosides and hydrogenated starch hydrolysate is too low, for example, being lower than 0.1 parts by weight, then its above-mentioned improvement effect is unobvious, if but accounting for
Than excessive, such as Fructus Hordei Germinatus oligose glucoside is more than 30 parts by weight and/or hydrogenated starch hydrolysate is more than 20 parts by weight, then in turn
Will affect the performance of spinning again, for example, fibre strength it is too low, reduce skin nursing effect etc..
Preferably, in facial mask of the invention, layers of nanofibers further comprises: the high polymerization degree of 0.1-5 parts by weight
Polyethylene glycol and 0.1-10 parts by weight low polymerization degree polyethylene glycol, the preferably high polymerization degree of 0.5-2 parts by weight
The polyethylene glycol of polyethylene glycol and the low polymerization degree of 0.5-5 parts by weight；Wherein, the polyethylene glycol of high polymerization degree used
Average molecular weight is between 250000-350000, and the average molecular weight of the polyethylene glycol of low polymerization degree used is in 6000-
Between 10000.
The polyethylene glycol of high polymerization degree can increase the tenacious and persistent will etc. of fiber, so that spinning becomes relatively easily, Er Qieneng
So that spinning is uniform；The polyethylene glycol of low polymerization degree can further prevent the clustering phenomena during electrostatic spinning, promote to be formed
Uniform spinning.
Preferably, in facial mask of the invention, the average molecular weight of the polyethylene glycol of low polymerization degree used is in 7000-
Between 9000；It is highly preferred that the average molecular weight of the polyethylene glycol of low polymerization degree used is between 7600-8600.
As a specific embodiment of the invention, in facial mask of the invention, layers of nanofibers includes:
The Sodium Hyaluronate of 3-20 parts by weight
The Hydrolyzed Collagen of 6-25 parts by weight
The Fructus Hordei Germinatus oligose glucoside of 0.5-6 parts by weight
The hydrogenated starch hydrolysate of 0.5-4 parts by weight
The polyethylene glycol of the high polymerization degree of 0.1-3 parts by weight
The polyethylene glycol of the low polymerization degree of 0.1-6 parts by weight；And
The surface reactive material of 0.1-2 parts by weight.
As another embodiment of the present invention, in facial mask of the invention, layers of nanofibers includes:
The Sodium Hyaluronate of 5-20 parts by weight
The Hydrolyzed Collagen of 10-25 parts by weight
The Fructus Hordei Germinatus oligose glucoside of 1.0-3 parts by weight
The hydrogenated starch hydrolysate of 0.8-2 parts by weight
The polyethylene glycol of the high polymerization degree of 0.5-3 parts by weight
The polyethylene glycol of the low polymerization degree of 0.5-8 parts by weight；And
The surface reactive material of 0.1-0.8 parts by weight.
In facial mask of the invention, it may further include one and be located on layers of nanofibers, strippable protective layer.
In the product design, final product has three layers, and non-woven fabrics is just spun on the nonwoven substrate as bottom liner, electrostatic spinning
Face, it is exactly middle layer (layers of nanofibers) that electrostatic spinning, which is formed by silk, and there are also one layer of overlay film, the films can be PE for outer layer
Film is also possible to BOPP film, but needs to remove electrostatic.This product using when be not required to removing fibrous layer, only need to open outside
Overlay film, so that it may use；Product can match nutrient solution, can also be unworthy of, consumer need to only spray pure water on the face, so that it may so that
With.
Further, in facial mask of the invention, layers of nanofibers may include the functional object of 0.001-2 parts by weight
Matter, such as preservative such as five sodium of Pentetic Acid, phytic acid, silver oxide etc. or other skin-care agents etc..
In addition, can be substituted with budding short stalk enzyme polysaccharide (pulullan polysaccharide) to reduce the cost of facial mask of the present invention
Partial Sodium Hyaluronate, resulting facial mask still have excellent performance.For example, the layers of nanofibers of facial mask of the present invention includes:
The Sodium Hyaluronate of 5-10 parts by weight
The budding short stalk enzyme polysaccharide of 5-25 parts by weight
The Hydrolyzed Collagen of 6-50 parts by weight；And
The surface reactive material of 0.1-5 parts by weight；
Wherein, the average molecular weight of budding short stalk enzyme polysaccharide is between 100000-300000, preferably in 150000-
Between 250000.Or the layers of nanofibers of facial mask of the present invention includes:
The Sodium Hyaluronate of 5-10 parts by weight
The budding short stalk enzyme polysaccharide of 5-10 parts by weight
The Hydrolyzed Collagen of 6-30 parts by weight；And
The surface reactive material of 0.5-3 parts by weight.
On the other hand, to achieve the purpose of the present invention, the present invention also provides a kind of method for preparing above-mentioned facial mask,
In, this method comprises the following steps that
(1), using pure water as solvent, Sodium Hyaluronate, Hydrolyzed Collagen, surface-active the preparation of spinning solution: is added
Substance, stirring form uniform spinning solution, which includes by the hydrolysis glue of the Sodium Hyaluronate of 1-30wt%, 5-50wt%
The surface reactive material of former albumen and 0.1-5wt%；
(2), electrostatic spinning: the spinning solution of above-mentioned preparation is added in the equipment of electrostatic spinning, is to receive with non-woven fabrics
Substrate carries out electrostatic spinning；
Wherein, the average molecular weight of Sodium Hyaluronate used is between 30000-60000, Hydrolyzed Collagen used
Average molecular weight between 1000-3000.
Further, the Fructus Hordei Germinatus oligose Portugal of 0.1-20wt% is further included in above-mentioned preparation method, in spinning solution
The hydrogenated starch hydrolysate of glucosides and 0.1-15wt%；
Preferably, the also polyethylene glycol and 0.1- of the high polymerization degree containing 0.1-3wt% in above-mentioned spinning solution
The polyethylene glycol of the low polymerization degree of 10wt%, wherein the average molecular weight of the polyethylene glycol of high polymerization degree used is in 250000-
Between 350000, the average molecular weight of the polyethylene glycol of low polymerization degree used is between 6000-10000.
Roller type needleless electrospinning device, this equipment can be used in electrospinning device used in above-mentioned preparation process
Have the characteristics that big spinning amount, high production efficiency, spinning are uniform.
The Germicidal efficacy of surface sweeping Electronic Speculum confirms that the layers of nanofibers of facial mask of the present invention is highly uniform, no any conglomeration, knot
The defects of point, fracture of wire, hole, occurs, and ensure that active material is uniformly distributed, and utilization efficiency is high, and skin nursing is without dead angle；In this way,
It ensure that the arrangement mode for being formed by fibre structure close to Skin Cell, be more conducive to give full play to nursing effect.
Facial mask of the invention is a kind of stemness facial mask, this is convenient in carrying and saves；Facial mask of the invention is also that one kind is received
The instant facial mask of rice, when use only need to pure water or spraying equal products elder generation wet skin, be then coated with facial mask again, in several seconds in receive
Rice and flour film is just completely dissolved；The Germicidal efficacy of face-image analyzer confirms that facial mask wrinkle improvement effect of the invention is obvious.
In the following, in conjunction with the drawings and specific embodiments, the present invention is further illustrated, but these specific embodiments
Just for the explanation of the certain specific specific embodiments of the present invention, it is not limited to the present invention.
Detailed description of the invention
Fig. 1-4 is the surface sweeping electron microscope that electrostatic spinning is formed by nanofiber in facial mask of the present invention, wherein Tu1-2Zhong
The average diameter of shown fiber is 0.21 μm, and the average diameter of shown fiber is 0.17 μm in Fig. 3-4；
Fig. 5 is the comparison diagram using face whole before and after facial mask of the present invention, wherein left figure is before use, right figure is using rear；
Fig. 6 is the comparison diagram using local face before and after facial mask of the present invention, wherein left figure be before use, right figure be using
Afterwards；
Fig. 7 is using the comparison diagram at eye pouch before and after facial mask of the present invention, wherein left figure is before use, right figure is using rear.
Specific embodiment
Embodiment 1
Facial mask of the invention is prepared as follows:
(1), it prepares spinning solution: using pure water as solvent, Sodium Hyaluronate, Hydrolyzed Collagen, Fructus Hordei Germinatus oligose glucose is added
Glycosides, hydrogenated starch hydrolysate, PEG-7M, PEG-180, Natrulon H-10 myristinate, preservative, in 20 DEG C -50 DEG C of constant temperature
2-6 hour of stirred in water bath, until solution is uniformly without particle, obtain the spinning solution comprising following component: 10wt%'s is transparent
Matter acid sodium, the Hydrolyzed Collagen of 5wt%, the Fructus Hordei Germinatus oligose glucoside of 2wt%, the hydrogenated starch hydrolysate of 1wt%, 2wt%
PEG-7M (PEG of high polymerization degree), the PEG-180 (PEG of low polymerization degree) of 2wt%, 1wt% Natrulon H-10 nutmeg
The preservative of acid esters and 0.2wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 30000, water used
The average molecular weight for solving collagen is about 2000, and the average molecular weight of PEG-7M used is about 300000, PEG- used
180 average molecular weight is about 8000, and preservative used is five sodium of Pentetic Acid, phytic acid, silver oxide；
(2), electrostatic spinning: the homogeneous solution of above-mentioned preparation is poured into the hopper of electrospinning device, controls spinning ring
The humidity in border is 30%-50%, and spinning distance is 140mm-220mm, spinning voltage 40KV-85KV, spinning speed 0.1-1.2
Rev/min, electric current 0.2-1.5mA is to receive substrate to carry out electrostatic spinning with non-woven fabrics.
Embodiment 2
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 15wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 3wt%, the Fructus Hordei Germinatus oligose glucoside of 0.5wt%, 0.5wt% hydrogenated starch water
Solve object, 0.5wt% high polymerization degree PEG, 5wt% low polymerization degree PEG, 5.0wt% polysorbate -20 and
The preservative of 0.1wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 25000, Hydrolyzed Collagen used
Average molecular weight be about 1200, the average molecular weight of the PEG of high polymerization degree used is about 250000, low polymerization degree used
The average molecular weight of PEG be about 10000.
Embodiment 3
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 5wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 30wt%, the Fructus Hordei Germinatus oligose glucoside of 5wt%, 3wt% hydrogenated starch hydrolysis
Object, 1wt% high polymerization degree PEG, 2wt% low polymerization degree PEG, 0.2wt% Surfhope SE Cosme C 1216 and
The preservative of 2.0wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 50000, Hydrolyzed Collagen used
Average molecular weight be about 3000, the average molecular weight of the PEG of high polymerization degree used is about 350000, low polymerization degree used
The average molecular weight of PEG be about 9000.
Embodiment 4
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 3wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 6wt%, the Fructus Hordei Germinatus oligose glucoside of 20wt%, 10wt% hydrogenated starch hydrolysis
Object, 1.5wt% high polymerization degree PEG, 10wt% low polymerization degree PEG, 3wt% coco-glucosides and 1.0wt%
Preservative, wherein the average molecular weight of Sodium Hyaluronate used is about 55000-60000, Hydrolyzed Collagen used
Average molecular weight be about 2600, the average molecular weight of the PEG of high polymerization degree used is about 280000, low polymerization degree used
The average molecular weight of PEG be about 7000.
Embodiment 5
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 2wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 9wt%, the Fructus Hordei Germinatus oligose glucoside of 10wt%, 15wt% hydrogenated starch hydrolysis
Object, 2wt% high polymerization degree PEG, 1wt% low polymerization degree PEG, 1.5wt% Cremophor RH40 and
The preservative of 0.5wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 40000, Hydrolyzed Collagen used
Average molecular weight be about 2300, the average molecular weight of the PEG of high polymerization degree used is about 320000, low polymerization degree used
The average molecular weight of PEG be about 7600.
Embodiment 6
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 8wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 15wt%, the Fructus Hordei Germinatus oligose glucoside of 6wt%, 3wt% hydrogenated starch hydrolysis
Object, 0.8wt% high polymerization degree PEG, 0.3wt% low polymerization degree PEG, 1.8wt% -6 caprylate of polyglycereol and
The preservative of 0.3wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 33000, Hydrolyzed Collagen used
Average molecular weight be about 2100, the average molecular weight of the PEG of high polymerization degree used is about 330000, low polymerization degree used
The average molecular weight of PEG be about 7800.
Embodiment 7
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 12wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 8wt%, 1.2wt% -6 caprylate of polyglycereol, wherein hyaluronic acid used
The average molecular weight of sodium is about 36000, and the average molecular weight of Hydrolyzed Collagen used is about 1900.
Embodiment 8
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 8wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 12wt%, the Fructus Hordei Germinatus oligose glucoside of 3wt%, 2wt% hydrogenated starch hydrolysis
Object, -6 caprylate of polyglycereol of 0.8wt% and the preservative of 0.1wt%, wherein the average mark of Sodium Hyaluronate used
Son amount about 39000, the average molecular weight of Hydrolyzed Collagen used is about 2300.
Embodiment 9
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 10wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 10wt%, 1.2wt% high polymerization degree PEG, 5.3wt% low polymerization degree
- 6 caprylate of polyglycereol of PEG, 1.8wt%, wherein the average molecular weight of Sodium Hyaluronate used is about 43000, used
The average molecular weight of Hydrolyzed Collagen is about 2000, and the average molecular weight of the PEG of high polymerization degree used is about 230000, institute
The average molecular weight of the PEG of low polymerization degree is about 7500.
Embodiment 10
Facial mask is prepared by the identical step of embodiment 1 and mode, but prepared spinning solution includes following component: 3wt%
Sodium Hyaluronate, the Hydrolyzed Collagen of 10wt%, the budding short stalk enzyme polysaccharide of 10wt%, 0.5wt% high polymerization degree
- 6 caprylate of polyglycereol of PEG, 1.8wt% of the low polymerization degree of PEG, 5.3wt%, wherein Sodium Hyaluronate used is put down
Average molecular weight is about 41000, and the average molecular weight of Hydrolyzed Collagen used is about 2000, the PEG of high polymerization degree used
Average molecular weight be about 230000, the average molecular weight of the PEG of low polymerization degree used is about 7500, the short stalk of budding used
The average molecular weight of enzyme polysaccharide is about 200000.
Embodiment 11
Prepare facial mask by the identical step of embodiment 1 and mode, but the facial mask further spinning once (layers of nanofibers)
On the step of forming strippable PE film protective layer, and remove electrostatic.I.e. final facial mask has three layers, and non-woven fabrics is the bottom of as
Lining, electrostatic spinning are just spun on the nonwoven substrate, and it is exactly middle layer (layers of nanofibers) that electrostatic spinning, which is formed by silk,.One
A product packaging may include several facial masks, which can be furnished with reservoir, such as small-sized sprinkler.
Electron microscope experiment and face-image analysis experiment
Layers of nanofibers is formed by electrostatic spinning using scanning electron microscope to observe, it may be clearly seen that, institute's shape
At fiber it is relatively uniform, and without any conglomeration, agglomeration, node, breakpoint and cavity formed, please refer to Fig. 1-Fig. 4；Institute's shape
At the even diameter of fiber generally between 0.10 μm -0.30 μm；Wherein, the average diameter of shown fiber is in Fig. 1-2
0.21 μm, the average diameter of shown fiber is 0.17 μm in Fig. 3-4.
Using the face-image analyzer VISIA-CR of Manfield company, the U.S., the use for using facial mask of the present invention to one
Skin of the person before and after use is analyzed, and as a result sees Fig. 5-Fig. 7.Wherein, Fig. 5 is pair using face whole before and after facial mask of the present invention
Than figure, wherein left figure is before use, right figure is using rear；Fig. 6 be using the comparison diagram of local face before and after facial mask of the present invention,
Wherein, left figure is before use, right figure is using rear；Fig. 7 is using the comparison diagram before and after facial mask of the present invention at eye pouch, wherein left
Figure is before use, right figure is using rear.Fig. 5 is shown, before facial mask, the L value of face is 84.95353, after facial mask, face
The L value in portion is 85.31294, more coloured and dazzling after use；Fig. 6 is shown, the wrinkle accounting before facial mask, in selection area
It is 16.45%, after facial mask, the wrinkle accounting in selection area is 13.38%, obvious using rear wrinkle improvement effect；Fig. 7 is aobvious
Show, before facial mask, selecting the wrinkle accounting in eye pouch region is 18.84%, after facial mask, selectes the wrinkle in eye pouch region
Line accounting is 15.33%, more obvious to the wrinkle improvement effect of eye pouch after use.
Claims (10)
1. a kind of using hyaluronic acid as the instant facial mask of collagen nanometer of skeleton, which includes non-woven fabrics base material layer and nanofiber
Layer, wherein the layers of nanofibers is formed on the non-woven fabrics base material layer using the method for electrostatic spinning, this is received
Rice fibrous layer include:
The Sodium Hyaluronate of 1-30 parts by weight
The Hydrolyzed Collagen of 5-50 parts by weight；And
The surface reactive material of 0.1-5 parts by weight；
Wherein, the average molecular weight of Sodium Hyaluronate used between 20000-60000, put down by Hydrolyzed Collagen used
Average molecular weight is between 1000-3000；
Wherein, the mass ratio of the Sodium Hyaluronate and the Hydrolyzed Collagen is between 1:5 to 6:1, preferably in 1:3
To between 3:1.
2. facial mask as described in claim 1, wherein the layers of nanofibers further comprises:
The Fructus Hordei Germinatus oligose glucoside of 0.1-20 parts by weight
The hydrogenated starch hydrolysate of 0.1-15 parts by weight.
3. the facial mask as described in one of claim 1-2, wherein the layers of nanofibers further comprises:
The polyethylene glycol of the high polymerization degree of 0.1-4 parts by weight
The polyethylene glycol of the low polymerization degree of 0.1-10 parts by weight
Wherein, the average molecular weight of the polyethylene glycol of high polymerization degree used is between 250000-350000, oligomerization used
The average molecular weight of the polyethylene glycol of degree is between 6000-10000.
4. facial mask as claimed in claim 3, wherein the layers of nanofibers of the facial mask includes:
The Sodium Hyaluronate of 3-20 parts by weight
The Hydrolyzed Collagen of 10-25 parts by weight
The Fructus Hordei Germinatus oligose glucoside of 0.5-6 parts by weight
The hydrogenated starch hydrolysate of 0.5-4 parts by weight
The polyethylene glycol of the high polymerization degree of 0.1-3 parts by weight
The polyethylene glycol of the low polymerization degree of 0.1-6 parts by weight；And
The surface reactive material of 0.1-2 parts by weight.
5. the facial mask as described in one of claim 1-4, wherein the layers of nanofibers further comprises:
The budding short stalk enzyme polysaccharide of 5-25 parts by weight
Wherein, sprout short stalk enzyme polysaccharide average molecular weight between 100000-300000, preferably 150000-250000 it
Between.
6. facial mask as claimed in claim 5, wherein the surface reactive material is Natrulon H-10 myristinate.
7. facial mask as described in claim 1, wherein the facial mask further comprises one on the layers of nanofibers
, strippable protective layer.
8. facial mask as claimed in claim 6, wherein the layers of nanofibers further comprises the function of 0.001-2 parts by weight
It can property substance.
9. a kind of method for preparing the facial mask as described in one of claim 1-8, wherein the method comprises the following steps that
(1), the preparation of spinning solution: using pure water as solvent, being added Sodium Hyaluronate, Hydrolyzed Collagen, surface reactive material,
Stirring forms uniform spinning solution, which includes by the hydrolytic collagen egg of the Sodium Hyaluronate of 1-30wt%, 5-50wt%
White and 0.1-5wt% surface reactive material；
(2), electrostatic spinning: the spinning solution of above-mentioned preparation is added in the equipment of electrostatic spinning, is to receive substrate with non-woven fabrics
Carry out electrostatic spinning；
Wherein, the average molecular weight of Sodium Hyaluronate used between 30000-60000, put down by Hydrolyzed Collagen used
Average molecular weight is between 1000-3000.
10. method as claimed in claim 9, wherein the malt for further including 0.1-20wt% in the spinning solution is few
The hydrogenated starch hydrolysate of sugared glucoside and 0.1-15wt%；Preferably, also containing 0.1-3wt%'s in the spinning solution
The polyethylene glycol of the low polymerization degree of the polyethylene glycol and 0.1-10wt% of high polymerization degree, wherein the high polymerization degree gathers
Between 250000-350000, the average molecular weight of the polyethylene glycol of the low polymerization degree exists the average molecular weight of ethylene glycol
Between 6000-10000.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110448471A (en) * | 2019-08-22 | 2019-11-15 | 苏州绿叶日用品有限公司 | A kind of nanofiber whitening mask and preparation method thereof |
| CN110664619A (en) * | 2019-10-30 | 2020-01-10 | 诺斯贝尔化妆品股份有限公司 | Collagen nano instant mask of yeast recombinant collagen and preparation method thereof |
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| CN112618410A (en) * | 2019-10-08 | 2021-04-09 | 轴心纤维有限公司 | Plant-based polysaccharide nanofiber matrices with functional ingredients for skin care products |
| CN112626712A (en) * | 2019-10-08 | 2021-04-09 | 轴心纤维有限公司 | Polysaccharide and protein nanofiber matrices with functional ingredients for skin care products |
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| CN115305590A (en) * | 2021-12-30 | 2022-11-08 | 希纤新材料(广州)有限公司 | Composite fiber for mask base cloth and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| CN103784330A (en) * | 2012-12-30 | 2014-05-14 | 苏州福兴纳米科技有限公司 | Facial mask and method for producing same |
| CN107898716A (en) * | 2018-01-19 | 2018-04-13 | 河南工程学院 | A kind of preparation method of nanofiber dry type facial mask |
| CN108283607A (en) * | 2018-01-22 | 2018-07-17 | 广西科学院 | A kind of spinning liquid, i.e. spinning nanometer facial mask and preparation method thereof |
| CN108866820A (en) * | 2017-05-12 | 2018-11-23 | 深圳瑞祥居科技发展有限公司 | A kind of preparation method and application of Electrospun nano-fibers |
-
2019
- 2019-01-21 CN CN201910052945.0A patent/CN109568173B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| CN103784330A (en) * | 2012-12-30 | 2014-05-14 | 苏州福兴纳米科技有限公司 | Facial mask and method for producing same |
| CN108866820A (en) * | 2017-05-12 | 2018-11-23 | 深圳瑞祥居科技发展有限公司 | A kind of preparation method and application of Electrospun nano-fibers |
| CN107898716A (en) * | 2018-01-19 | 2018-04-13 | 河南工程学院 | A kind of preparation method of nanofiber dry type facial mask |
| CN108283607A (en) * | 2018-01-22 | 2018-07-17 | 广西科学院 | A kind of spinning liquid, i.e. spinning nanometer facial mask and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孙晓斌，等: "普鲁兰多糖纳米纤维膜制备及交联工艺研究", 《合成纤维》 * |
| 陈云波，等: "麦芽寡糖基糖苷/氢化淀粉水解物在化妆品中的应用", 《广东化工》 * |
Cited By (14)
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| CN112259901A (en) * | 2019-07-03 | 2021-01-22 | 比亚迪股份有限公司 | Gluing diaphragm for lithium ion battery and preparation method and application thereof |
| CN110448471A (en) * | 2019-08-22 | 2019-11-15 | 苏州绿叶日用品有限公司 | A kind of nanofiber whitening mask and preparation method thereof |
| CN112626712A (en) * | 2019-10-08 | 2021-04-09 | 轴心纤维有限公司 | Polysaccharide and protein nanofiber matrices with functional ingredients for skin care products |
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| CN110664619A (en) * | 2019-10-30 | 2020-01-10 | 诺斯贝尔化妆品股份有限公司 | Collagen nano instant mask of yeast recombinant collagen and preparation method thereof |
| JP2023500191A (en) * | 2019-10-30 | 2023-01-05 | ノックス ベルカウ コズメティックス カンパニー リミテッド | Collagen nano instant face pack containing yeast recombinant collagen and method for producing the same |
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