CN114272149A - Preparation method and application of dressing containing astaxanthin - Google Patents
Preparation method and application of dressing containing astaxanthin Download PDFInfo
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- CN114272149A CN114272149A CN202110142419.0A CN202110142419A CN114272149A CN 114272149 A CN114272149 A CN 114272149A CN 202110142419 A CN202110142419 A CN 202110142419A CN 114272149 A CN114272149 A CN 114272149A
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Abstract
The invention relates to a preparation method and application of a dressing containing astaxanthin. The astaxanthin-containing dressing comprises a mask base material, a nanofiber layer and a protective layer which are sequentially stacked, wherein the nanofiber layer comprises the following components in parts by weight: 0.01-2 parts of astaxanthin, 0-15 parts of moisturizing component, 0-10 parts of whitening component, 0-10 parts of natural plant active component, 0-5 parts of penetration enhancer, 2-70 parts of high molecular polymer and 20-100 parts of solvent. According to the invention, substances which are difficult to dissolve in water are wrapped in the polymer fibers by utilizing an electrostatic spinning technology to form a dry nanofiber membrane, so that the stimulation of a solvent to the skin is reduced, meanwhile, the polymer protects the effective components such as astaxanthin and the like wrapped in the polymer, so that the polymer can stably exist, the effective components wrapped in the polymer can be released in the form of nano microspheres after the polymer is dissolved in water, the effective components are small in size and easy to be absorbed by skin tissues, no preservative is added, the use is convenient and safe, and the effects of resisting aging, whitening, removing freckles and removing wrinkles are obvious.
Description
Technical Field
The invention relates to the field of medical materials, medical treatment and cosmetology, in particular to a preparation method and application of a dressing containing astaxanthin.
Background
Recent researches prove that natural astaxanthin has extremely strong antioxidant activity which is 550 times that of vitamin E and 10 times that of carotenoid, and is praised as 'super vitamin E'. Astaxanthin serving as a chain-breaking antioxidant can effectively inhibit lipid peroxidation caused by free radicals, can enhance immunity, can eliminate various physiological effects such as in vivo free radicals and the like, has a good treatment effect on skin cancer caused by ultraviolet rays, and has wide application in the aspects of medical treatment, cosmetology and the like.
However, astaxanthin has poor solubility and stability, so that it is greatly limited in application. There are problems as follows: 1) astaxanthin is insoluble in water and cannot be well applied to a plurality of cosmetics; 2) is not easy to be absorbed by the skin, which affects the efficacy; 3) astaxanthin is unstable and inconvenient to store and use; 4) astaxanthin is too dark in color and too much in addition, so that skin staining is easily caused, and the beauty is affected.
The nanofiber membrane prepared by the electrostatic spinning technology has the advantages of small fiber diameter, good biocompatibility and degradability of some electrospinning raw materials, capability of being used as a material for repairing tissues and organs, capability of being used as a carrier, and application in aspects of drug controlled release, wound repair, biological tissue engineering and the like. In addition, the nanofiber membrane prepared by the electrostatic spinning technology is a dry membrane, and in the electrospinning process, the solvent is volatilized, so that the influence of the solvent on skin tissues is reduced.
Disclosure of Invention
In view of the problems of the prior art, the invention aims to provide a preparation method of astaxanthin-containing dressing and application thereof. According to the invention, substances which are difficult to dissolve in water are wrapped in the polymer fibers by utilizing an electrostatic spinning technology to form a dry nanofiber membrane, so that the stimulation of a solvent to the skin is reduced, meanwhile, the polymer protects the effective components such as astaxanthin and the like wrapped in the polymer, so that the effective components can exist stably, the effective components wrapped in the polymer can be released in the form of nano microspheres after the polymer is dissolved in water, the effective components are small in size and easy to be absorbed by skin tissues, no preservative is added, the use is safer, and the effect is good.
In order to achieve the purpose, the invention adopts the following technical scheme.
The dressing containing the astaxanthin comprises a mask base material, a nanofiber layer and a protective layer which are sequentially stacked, wherein the nanofiber layer comprises the astaxanthin, a moisturizing component, a whitening component, a natural plant active component, a penetration enhancer, a high molecular polymer and a solvent, and the dressing comprises the following components in parts by weight: 0.01-2 parts of astaxanthin, 0-15 parts of moisturizing component, 0-10 parts of whitening component, 0-10 parts of natural plant active component, 0-5 parts of penetration enhancer, 2-70 parts of high molecular polymer and 20-100 parts of solvent.
Further, the moisture-keeping component comprises one or more of urea, sorbitol, sodium pyrrolidone carboxylate, trehalose, sodium hyaluronate, dipotassium glycyrrhizinate, beta-glucan, panthenol, erythritol, hydroxyethyl urea, ceramide, hyaluronic acid, amino acids, glycerol, propylene glycol, butylene glycol and collagen.
Further, the whitening component comprises one or more of arbutin, nicotinamide, tranexamic acid, phenethyl resorcinol, hydrolyzed conchiolin, astaxanthin, vitamin C, glutathione, glabridin, retinol acetate, tartaric acid, kojic acid and tranexamic acid.
Further, the natural plant active ingredients comprise one or more of asiaticoside, chamomile extract, abalone extract, lignin, ceruleus extract, peony root extract, chlorella extract, papaya extract, aloe vera extract, mulberry extract, portulaca oleracea extract, tropaeolum extract, rhodophyta extract, hamamelis virginiana extract, phloretin, resveratrol, paeoniflorin and paeonol.
Further, the penetration enhancer comprises one or more of azone, isosorbide dimethyl ether, N-N-alkyl benzisothiazolone, inositol, piperine, decyl methyl sulfoxide and menthol.
Further, the polymer comprises one or more of polyvinyl alcohol, polyethylene glycol, polyvinyl butyral, polyvinyl pyrrolidone, polyethylene oxide, gelatin, hyaluronic acid, chitosan, polyethyleneimine, polypropylene and polylactic acid.
The solvent is one or more of water, ethanol solution, acetic acid water solution, acetone, dichloromethane, N-dimethylformamide or ethyl acetate.
The preparation method of the dressing containing astaxanthin comprises the following steps.
And 2, dissolving a high molecular polymer in the electrostatic spinning solution 1 prepared in the step 1 to obtain an electrostatic spinning solution 2.
And 3, carrying out electrostatic spinning on the electrostatic spinning solution 2 prepared in the step 2 to a receiving base material through an electrostatic spinning technology, and forming a nanofiber layer on the surface of the receiving base material to obtain the nanofiber membrane containing the astaxanthin component.
And 4, atomizing the nanofiber membrane prepared in the step 3 to obtain the gel containing the effective component nanospheres.
Further, in the step 3, the voltage of electrostatic spinning is 10-100 kV, the current is 0.2-1.5 mA, the time of electrostatic spinning is 0.1-60 min, the humidity of the spinning environment is 30-50%, the spinning distance is 5-30 cm, the injection speed is 0.1-2 mL/min, and the spinning speed is 0.1-1.2 r/min.
Further, the receiving substrate in step 3 is preferably skin, silk mask substrate, spunlace nonwoven fabric, tencel nonwoven fabric, bio-fiber mask substrate, hydrogel mask substrate, melt-blown nonwoven fabric, nanofiber mask substrate, chitosan mask substrate or release paper.
The astaxanthin-containing dressing is applied to the preparation of anti-aging, whitening, repairing, beautifying and skin-care products and medical products.
In addition to the skin, the present invention may employ well-known commercially available products for the substrate. After the nanofiber layer is obtained, except the nanofiber layer spun to the skin, the invention attaches a protective layer on the surface of other nanofiber layers to obtain the astaxanthin dressing. In the present invention, the kind of the protective layer is not particularly limited, and an appropriate kind of the protective layer may be used.
In the invention, when the nanofiber layer is in a dry state, the nanofibers are attached to the receiving substrate, and when the nanofiber layer is in a wet state, the nanofiber layer can be immediately dissolved into an ultrathin transparent water-locking layer, and simultaneously, a large amount of effective factors which are easily absorbed by skin are released.
In the invention, the effective components such as astaxanthin, moisturizing components, whitening components, natural plant active components, penetration enhancer and the like are dissolved instantly after the fiber membrane is in water, the effective components are released from the nanofiber layer in the form of nano microspheres and enter the skin to realize quick absorption, and the macromolecular polymer can be left on the surface of the skin to form a water locking layer, thereby having zero burden on the skin.
The invention also provides application of the astaxanthin-containing dressing in the technical scheme in the fields of medical treatment and beauty. The mask disclosed by the invention is not only limited to the field of application medical treatment, but also can be applied to the field of beauty and skin care.
Compared with the prior art, the invention has the following beneficial effects.
(1) The spinning solution is mixed with astaxanthin, a moisturizing component, a whitening component, a natural plant active component, a penetration enhancer, a high molecular polymer and a solvent, so that the dressing has good whitening and antioxidant effects, the electrospinning solution is uniform and stable, the active components are not easy to deteriorate, and the active components are easier to absorb and have better effects due to the addition of a transdermal agent.
(2) The preparation method of the dressing containing the astaxanthin enables the water-insoluble medicine to be nanocrystallized and easier to absorb; the skin is prevented from contacting with a solvent, and the irritation is reduced; comfortable and convenient use, and remarkable effects of resisting aging, whitening skin, removing freckles and removing wrinkles. Many existing substances which are insoluble in water and soluble in ethanol cannot be used in the fields of medical treatment and beauty treatment due to the limitation of solubility, for example, the direct use of an alcohol solution as a solvent can generate strong irritation, so that the skin of a human body cannot adapt to or even generate certain allergic phenomena. The preparation method of the dressing provided by the invention can be used for skillfully solving the technical defects.
(3) The dressing provided by the invention contains astaxanthin which is soluble in ethanol but insoluble in water, the selected polymer can be soluble in alcohol and water, after the electrospun membrane is atomized, the polymer is dissolved, and the coated effective components such as astaxanthin and the like are released, so that the effective components exist in the polymer gel in the form of nano microspheres, the effective components are nanocrystallized, and the skin absorption is easier.
(4) After the dressing containing the astaxanthin is used by adding water into a nanofiber dry facial mask, all the used polymers are water-soluble and can form a gel state, so that the local skin is temporarily in a closed state, the skin hydration degree is increased, the aim of locking water is fulfilled, the skin is comfortable and has no burden, and no adverse effect is caused.
(5) Compared with the common dressing, the dressing containing the astaxanthin provided by the invention has the advantages that no preservative or irritant substance is added, the release and absorption of effective components can be realized only in a short time, the dressing is convenient and rapid, and the effect is obvious.
Drawings
Fig. 1 is a result of skin test conducted on the nano-dressing prepared in example 1 and a general astaxanthin mask.
FIG. 2 is a transmission electron microscope image of the organisms obtained after the nanofiber membrane prepared in example 1 is sprayed with water and atomized.
Detailed Description
The preparation method and application of the astaxanthin dressing provided by the invention are described in detail with reference to the following examples, but the preparation method and the application are not to be construed as limiting the scope of the invention.
A preparation method of the astaxanthin-containing dressing comprises the following steps.
And 2, dissolving a high molecular polymer in the electrostatic spinning solution 1 prepared in the step 1 to obtain an electrostatic spinning solution 2.
And 3, carrying out electrostatic spinning on the electrostatic spinning solution 2 prepared in the step 2 to a receiving base material through an electrostatic spinning technology, and forming a nanofiber layer on the surface of the receiving base material to obtain the nanofiber membrane containing the astaxanthin component.
And 4, atomizing the nanofiber membrane prepared in the step 3 to obtain the gel containing the effective component nanospheres.
Further, in the step 1, the composition in parts by weight is as follows: 0.01-2 parts of astaxanthin, 0-15 parts of moisturizing component, 0-10 parts of whitening component, 0-10 parts of natural plant active component, 0-5 parts of penetration enhancer, 2-70 parts of high molecular polymer and 20-100 parts of solvent.
Further, the moisture-keeping component comprises one or more of urea, sorbitol, sodium pyrrolidone carboxylate, trehalose, sodium hyaluronate, dipotassium glycyrrhizinate, beta-glucan, panthenol, erythritol, hydroxyethyl urea, ceramide, hyaluronic acid, amino acids, glycerol, propylene glycol, butylene glycol and collagen.
Further, the whitening component comprises one or more of arbutin, nicotinamide, tranexamic acid, phenethyl resorcinol, hydrolyzed conchiolin, astaxanthin, vitamin C, glutathione, glabridin, retinol acetate, tartaric acid, kojic acid and tranexamic acid.
Further, the natural plant active ingredients comprise one or more of asiaticoside, chamomile extract, abalone extract, lignin, ceruleus extract, peony root extract, chlorella extract, papaya extract, aloe vera extract, mulberry extract, portulaca oleracea extract, tropaeolum extract, rhodophyta extract, hamamelis virginiana extract, phloretin, resveratrol, paeoniflorin and paeonol.
Further, the penetration enhancer comprises one or more of azone, isosorbide dimethyl ether, N-N-alkyl benzisothiazolone, inositol, piperine, decyl methyl sulfoxide and menthol.
Further, the polymer comprises one or more of polyvinyl alcohol, polyethylene glycol, polyvinyl butyral, polyvinyl pyrrolidone, polyethylene oxide, gelatin, hyaluronic acid, chitosan, polyethyleneimine, polypropylene and polylactic acid.
Further, the solvent is one or more of water, ethanol solution, acetic acid water solution, acetone, dichloromethane, N-dimethylformamide or ethyl acetate.
Further, in the step 3, the voltage of electrostatic spinning is 10-100 kV, the current is 0.2-1.5 mA, the time of electrostatic spinning is 0.1-60 min, the humidity of the spinning environment is 30-50%, the spinning distance is 5-30 cm, the injection speed is 0.1-2 mL/min, and the spinning speed is 0.1-1.2 r/min.
Further, the receiving substrate in step 3 is preferably skin, silk mask substrate, spunlace nonwoven fabric, tencel nonwoven fabric, bio-fiber mask substrate, hydrogel mask substrate, melt-blown nonwoven fabric, nanofiber mask substrate, chitosan mask substrate or release paper.
Example 1.
The dressing containing the astaxanthin comprises the following raw materials in parts by weight: 0.05 part of astaxanthin, 2 parts of butanediol, 2 parts of arbutin, 1.8 parts of centella asiatica extract, 0.8 part of paeoniflorin, 1.7 parts of azone, 12.5 parts of PVP and 100 parts of ethanol.
Example 2.
The dressing containing the astaxanthin comprises the following raw materials in parts by weight: 0.05 part of astaxanthin, 3 parts of vitamin C, 2 parts of butanediol, 2 parts of arbutin, 1.8 parts of centella extract, 0.8 part of paeoniflorin, 1.7 parts of azone, 12.5 parts of PVP and 100 parts of ethanol, and the dressing is prepared according to the preparation method.
Example 3.
The dressing containing the astaxanthin comprises the following raw materials in parts by weight: 0.1 part of astaxanthin, 3 parts of glycerol, 3 parts of nicotinamide, 1 part of purslane extract, 0.1 part of paeonol, 1 part of inositol, 14.6 parts of PEO and 100 parts of ethanol.
Comparative example 1.
The solution comprises the following components in parts by weight: astaxanthin 0.05, butanediol 2, arbutin 2, centella asiatica extract 1.8, paeoniflorin 0.8, azone 1.7, PVP 12.5 and ethanol 100, and mixing well.
Example 5 evaluation of the effects of the casting products prepared according to the present invention.
1. And (5) testing whitening and anti-aging effects.
30 persons were randomly selected as the subjects of the examples, the electrospinning liquid of examples 1-3 was used, the dressing was directly spun on the facial skin of the subjects by using a handheld device, atomized by water spraying, sufficiently absorbed and washed without using any cosmetics. Randomly selecting 10 persons as reference substances, applying some astaxanthin cream on the face of the reference substances, and washing after sufficient absorption, wherein no cosmetic is suitable. The clinician visits regularly, and the whitening effect test: the skin color of the subject was measured by a commercially available colorimeter, and Δ L was calculated by measuring the value of L before and after the measurement, and the difference in skin color between before and after the use of the subject was expressed by Δ L, and the calculation formula was: Δ L — luminance at each test L2 — luminance before use L1. And (3) testing the anti-aging effect: wrinkles of facial skin were detected using a commercially available VISIA skin detector and the data results are shown in table 1.
Table 1. evaluation results of whitening anti-aging efficacy.
As can be seen from table 1, the whitening anti-aging efficacy of astaxanthin is better than that of other ingredients by comparing the data of whitening anti-aging efficacy of example 1 and example 2; comparing the data of example 1 and example 3, it can be seen that the effect of the amount of astaxanthin used on the whitening anti-aging effect is better, the higher the astaxanthin concentration is. Further proves that the astaxanthin dressing has good whitening and anti-aging effects. The data of example 1 and the comparative example show that the electrospun membrane prepared by the electrospinning technology can enable the active ingredients to be better absorbed by skin tissues.
2. And (5) testing the storage stability.
The solutions of example 1, example 3 and comparative example 1 were stored in an oven at 25 ± 4 degrees celsius and the stability of the solutions was observed and the results are shown in table 2.
Table 2 solution stability test results.
As can be seen from Table 2, the spinning solution containing astaxanthin was still in a uniform and stable state after being left at a constant temperature for 3 months. In contrast, the astaxanthin solution in comparative example 1 was left for two months, and precipitates were formed, and astaxanthin was oxidized.
3. And (5) evaluating using feeling.
The nano-dressing prepared in example 1 and a normal astaxanthin mask were separately dispensed to volunteers for skin testing. The volunteers score the feelings of use after using the product, the score range is 1-10, and the higher the score is, the better the experience feeling is represented. Average values given by volunteers are shown in fig. 1, and it can be seen that the astaxanthin dressing prepared in example 1 is better than a common astaxanthin mask in use, and the astaxanthin nano dressing is convenient to use, the nanofibers are dissolved in water, the active ingredients are completely absorbed by the skin, the dressing has a sense of tightness after use and does not need to be cleaned, and the nanofiber has good air permeability due to the porous structure, good conformability and strong use comfort.
4. And (5) detecting the nano microspheres.
The nanofiber membrane prepared in example 1 was sprayed with water and atomized, and then a transmission electron microscope image was taken. The polymer is dissolved in water to form gel, and the astaxanthin wrapped in the gel exists in the polymer gel in the form of nano microspheres with the size of about 30-50nm, and the result is shown in figure 2.
Claims (10)
1. The dressing containing the astaxanthin is characterized by comprising a mask base material, a nanofiber layer and a protective layer which are sequentially stacked, wherein the nanofiber layer comprises the astaxanthin of a human body, a moisturizing component, a whitening component, a natural plant active component, a penetration enhancer, a high molecular polymer and a solvent, and the dressing comprises the following components in parts by weight: 0.01-2 parts of astaxanthin, 0-15 parts of moisturizing component, 0-10 parts of whitening component, 0-10 parts of natural plant active component, 0-5 parts of penetration enhancer, 2-70 parts of high molecular polymer and 20-100 parts of solvent.
2. The astaxanthin-containing dressing of claim 1, wherein said moisturizing composition comprises one or more of urea, sorbitol, sodium pyrrolidone carboxylate, trehalose, sodium hyaluronate, dipotassium glycyrrhizinate, β -glucan, panthenol, erythritol, hydroxyethyl urea, ceramide, hyaluronic acid, amino acids, glycerol, propylene glycol, butylene glycol, collagen; the whitening component comprises one or more of arbutin, nicotinamide, tranexamic acid, phenethyl resorcinol, hydrolyzed conchiolin, astaxanthin, vitamin C, glutathione, glabridin, retinol acetate, tartaric acid, kojic acid and tranexamic acid.
3. The astaxanthin-containing dressing of claim 1, wherein the natural botanical active ingredient comprises one or more of asiaticoside, chamomile extract, abalone extract, lignin, ceruleus extract, peony root extract, chlorella extract, papaya extract, aloe vera extract, mulberry extract, portulaca oleracea extract, tropaeolum extract, red algae extract, hamamelis extract, phloretin, resveratrol, paeoniflorin, paeonol.
4. The astaxanthin-containing dressing of claim 1, wherein the penetration enhancer comprises one or more of azone, dimethyl isosorbide, N-alkylbenzisothiazolinone, inositol, piperonyl, decyl methyl sulfoxide, menthol.
5. The astaxanthin-containing dressing of claim 1, wherein said polymer comprises one or more of polyvinyl alcohol, polyethylene glycol, polyvinyl butyral, polyvinyl pyrrolidone, polyethylene oxide, gelatin, hyaluronic acid, chitosan, polyethyleneimine, polypropylene, polylactic acid.
6. The astaxanthin-containing dressing of claim 1, wherein said solvent is one or more of water, ethanol solution, aqueous acetic acid solution, acetone, dichloromethane, N-dimethylformamide or ethyl acetate.
7. A method of preparing a dressing containing astaxanthin according to claims 1 to 6, comprising the following steps:
step 1, adding astaxanthin, a moisturizing component, a whitening component, a natural plant active component and a penetration enhancer into a solvent, and uniformly mixing to obtain an electrostatic spinning solution 1;
step 2, dissolving a high molecular polymer in the electrostatic spinning solution 1 prepared in the step 1 to obtain an electrostatic spinning solution 2;
step 3, carrying out electrostatic spinning on the electrostatic spinning solution 2 prepared in the step 2 to a receiving base material through an electrostatic spinning technology, and forming a nanofiber layer on the surface of the receiving base material to obtain a nanofiber membrane containing the astaxanthin component;
and 4, atomizing the nanofiber membrane prepared in the step 3 to obtain the gel containing the effective component nanospheres.
8. The preparation method according to claim 7, wherein the voltage of the electrostatic spinning in the step 3 is 10 to 100kV, the current is 0.2 to 1.5mA, the electrostatic spinning time is 0.1 to 60min, the humidity of the spinning environment is 30 to 50 percent, the spinning distance is 5 to 30cm, the injection speed is 0.1 to 2mL/min, and the spinning speed is 0.1 to 1.2 r/min.
9. The method of claim 7, wherein the receiving substrate in step 3 is preferably skin, silk mask substrate, spunlace nonwoven fabric, tencel nonwoven fabric, bio-fiber mask substrate, hydrogel mask substrate, melt-blown nonwoven fabric, nanofiber mask substrate, chitosan mask substrate, or release paper.
10. The use of a dressing containing astaxanthin according to claim 1 for the preparation of anti-aging, whitening, repairing, cosmetic skin care and medical products.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115252871A (en) * | 2022-06-22 | 2022-11-01 | 哈尔滨工业大学 | Drug-loaded super-hydrophilic/super-hydrophobic Janus nanofiber membrane applicable to medical wound dressing and preparation method thereof |
| WO2024032549A1 (en) * | 2021-08-22 | 2024-02-15 | 张天平 | Nanofiber supramolecular skincare composition |
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| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| CN108578273A (en) * | 2018-04-24 | 2018-09-28 | 上海益好纳米科技有限公司 | A kind of nanofiber eye mask and preparation method thereof |
| CN108992363A (en) * | 2018-03-29 | 2018-12-14 | 世霸潜能科研有限公司 | A kind of surface has the nanofiber moisture saver mask and its preparation method and application of sticky hydroxy functional group |
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- 2021-02-02 CN CN202110142419.0A patent/CN114272149A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101390814A (en) * | 2008-10-29 | 2009-03-25 | 东南大学 | Beauty mask based on electro spinning nano fiber |
| CN108992363A (en) * | 2018-03-29 | 2018-12-14 | 世霸潜能科研有限公司 | A kind of surface has the nanofiber moisture saver mask and its preparation method and application of sticky hydroxy functional group |
| CN108578273A (en) * | 2018-04-24 | 2018-09-28 | 上海益好纳米科技有限公司 | A kind of nanofiber eye mask and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024032549A1 (en) * | 2021-08-22 | 2024-02-15 | 张天平 | Nanofiber supramolecular skincare composition |
| CN115252871A (en) * | 2022-06-22 | 2022-11-01 | 哈尔滨工业大学 | Drug-loaded super-hydrophilic/super-hydrophobic Janus nanofiber membrane applicable to medical wound dressing and preparation method thereof |
| CN115252871B (en) * | 2022-06-22 | 2023-10-03 | 哈尔滨工业大学 | Medicine-carrying super-hydrophilic/super-hydrophobic Janus nanofiber membrane applicable to medical wound dressing and preparation method thereof |
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