CN108283607B

CN108283607B - Spinning solution, instant-spinning nano mask and preparation method thereof

Info

Publication number: CN108283607B
Application number: CN201810059486.4A
Authority: CN
Inventors: 王青艳; 唐培朵; 朱婧; 秦艳; 龙思雨; 李亿; 梁戈; 杜齐石
Original assignee: Guangxi Academy of Sciences
Current assignee: Guangxi Academy of Sciences
Priority date: 2018-01-22
Filing date: 2018-01-22
Publication date: 2020-11-03
Anticipated expiration: 2038-01-22
Also published as: CN108283607A

Abstract

The invention relates to a spinning solution, namely a spinning nano facial mask and a preparation method thereof, wherein the spinning nano facial mask is different from the traditional facial mask, namely the spinning nano facial mask is a nano membrane invisible to eyes, is prepared from raw materials such as fish skin collagen and/or gelatin with good affinity with skin, is a non-woven fabric interwoven by nano-scale filaments, can bear various skin-care and moisture-preserving components, has natural appearance, good air permeability and moisture-preserving performance, elasticity, good self-feeling, no foreign body sensation and convenient use, and belongs to the field of cosmetic products.

Description

Spinning solution, instant-spinning nano mask and preparation method thereof

Technical Field

The invention belongs to the field of cosmetic products, and particularly relates to a spinning solution, namely a spinning nano facial mask and a preparation method thereof.

Background

Along with the economic development of China and the improvement of the living standard of people, the demand of people on skin care products is higher and higher, and a wide market is formed. In recent years, in many areas of China, the haze is serious, and the haze contains various germs and harmful substances and seriously damages the skin. In the north of China, the skin is cold and dry in winter, and the skin is seriously damaged due to strong ultraviolet rays in the plateau area in the northwest of China. Therefore, the skin care facial mask is gradually becoming a common product for people to quickly care skin. The electrostatic spinning is an advanced device for preparing organic polymer nano materials, and various organic polymer substances are originally used as raw materials to prepare nanoscale films, namely, nanoscale non-woven fabrics interwoven by filaments are used as industrial materials such as drug dispersants, catalyst carriers, nanofiltration membranes, haze-preventing environment-friendly films and the like. In recent years, electrostatic spinning technology has been used in the medical field to prepare high-end medical products such as artificial skin, periosteum, heart membrane, stents and the like. Through recent improvements and improvements of the electrospinning machine, simple table type and hand-held type electrospinning machines have been developed, the former being as large as a telephone base, and the latter being as small as a teacup and being held by hand to prepare a nano-film on site. However, the existing skin care mask can be used only at night at home, cannot be worn for travel in the daytime, and has limited effect; on the other hand, the skin care cream used in daytime is mainly oily substrate and has poor air permeability, so that a mask which is convenient to use, high in moisturizing effect, good in self-feeling and capable of being used when a user goes out in daytime, and capable of preventing haze and ultraviolet rays is urgently needed by vast women.

Disclosure of Invention

The invention provides a spinning solution, namely a spinning nano facial mask and a preparation method thereof, the spinning nano facial mask is different from the traditional facial mask, namely the spinning nano facial mask is a nano membrane invisible to eyes, is prepared from raw materials such as fish skin collagen and/or gelatin with good affinity with skin, is a non-woven fabric interwoven by nano-scale filaments, can bear various skin-care and moisture-preserving components, has natural appearance, good air permeability and moisture-preserving performance, is elastic, has good self-feeling and no foreign body feeling, and is convenient to use.

The invention is realized by the following technical scheme:

the spinning solution comprises 25-40% of a high-molecular substrate and 40-75% of a solvent by mass.

Further, the polymer substrate is any one or any two or more of collagen, gelatin, silk fibroin and chitosan; the polymer substrate is a polymer substance which contains more water (such as fish skin gelatin), has good moisturizing capability, has good affinity with skin, is easy to absorb, can be dissolved in water and is easy for electrostatic spinning; the polymer used as the substrate of the nanometer facial mask has no pungent odor, no dark color, preferably colorless, and good adhesiveness and elasticity on skin.

Further, the solvent comprises water, and the water is the best cleaning agent for the skin in nature, so the water is used as a basic formula of the textile solution, and a small amount (or no) of perfume is added as an auxiliary solvent.

Further, the water is deionized water, high purity water, distilled water, purified water, or mineral water.

Further, the gelatin is fish skin gelatin; the fish skin gelatin is a product of fish skin collagen which is structurally changed, and has a chemical composition similar to that of skin protein. The fish skin gelatin has strong hydrophilicity, jelly forming ability, interconversion between sol state and gel state, good film forming property, high side chain group reactivity, amphoteric electrolyte property, and charge change with medium pH value. The fish skin gelatin is colorless or yellowish transparent slice or particle. The gelatin can be dissolved in hot water, absorbs water to swell and soften, can absorb water which is 5-10 times of the weight of the gelatin, and is cooled to form a gelatinous substance which is suitable for being used as a substrate of the nano mask.

Further, the spinning solution also comprises 1-5% of skin-care and moisture-retention components by mass.

Further, the skin-care and moisturizing component is any one or any two or more of trehalose, glycerol, hydrolyzed collagen, hyaluronic acid, aloe and natural moisturizing factors.

Further, the spinning solution also comprises a cosmetic component with the mass fraction not more than 2% and/or a cosmetic component with the mass fraction not more than 2%.

Further, the cosmetic component is any one or any two or more of pearl powder, vitamin C, arbutin, white poria, whitening powder and glittering powder.

Further, the cosmetic component is perfume and/or rose oil.

Further, the perfume is any one or any two or more of lily, lavender perfume, jasmine perfume, gardenia perfume, rose perfume and osmanthus perfume.

Further, the silk fibroin preparation comprises the following specific contents: shearing silkworm cocoon with scissors, removing silkworm pupa, peeling silkworm cocoon into multiple layers, boiling in 0.5% sodium bicarbonate water solution (bath water ratio of 1: 100) for 30min, removing sericin on cocoon silk surface, and repeating the above steps twice. Then fully washing with deionized water, and finally airing. 10g of the degummed fibroin is taken, 9.5mol/L LiBr is used for preparing a solution with the concentration of 10 percent, and the solution is placed overnight. Adding deionized water to dilute 5 times, filtering, pouring into dialysis bag, and continuously dialyzing with deionized water until the conductivity of deionized water outside the dialysis bag is substantially unchanged.

The spinning nano facial mask is obtained by spinning a homogeneous spinning solution containing 25-40% of a high-molecular substrate and 40-75% of a solvent on paper;

the diameter of the fiber of the instant nano mask is 200 nm-400 nm.

Further, the polymer substrate is any one or any two or more of collagen, gelatin, silk fibroin and chitosan.

Furthermore, the solvent comprises water which is the best cleaning agent for the skin in nature, so that the water is used as a basic formula of the textile solution, and a small amount of (or no) perfume can be added as an auxiliary solvent.

Further, the spinning solution also comprises 1-5% of skin care and moisture retention components; further enhancing the skin care and moisture retention capability of the nano mask.

Further, the skin-care and moisture-retention component is any one or any two or more of trehalose, aloe, papain and hyaluronic acid.

Further, the cosmetic ingredients are any one or any two or three of pearl powder, whitening powder and glitter powder.

Further, the cosmetic component is perfume and/or rose oil.

Further, after the high molecular substrate and the solvent are determined in the spinning solution, the concentration of the substrate and the solvent in the spinning solution is a very critical factor; when the high molecular substrate is gelatin and the solvent is water, the concentration of the prepared gelatin spinning solution has a wider allowable range, generally speaking, the concentration is too low, liquid drops are speckled, and the silk cannot be formed; the concentration is low, the silk is thick, and the structure is loose; the diameter of the filaments decreases and then increases as the concentration increases; if the concentration is too high, solid balls appear; the concentration is proper, and a uniform, compact and smooth nano-film is formed; the concentration of the dope is also related to the molecular weight of the high molecular substance, and if the average molecular weight of the high molecular substance is high, the concentration can be lower; if the average molecular weight is low, the concentration is higher; the concentration of the gelatin dope also relates to the water content of the gelatin itself.

Furthermore, the instant nano mask has good moisture retention and air permeability, is natural in appearance, can be used when going out, has the effects of skin care, moisture retention and haze prevention for a long time, and has a better effect.

Furthermore, the instant nano mask can be prepared by users at any time, is simple and convenient to prepare, can be used as daily cosmetics, has a natural and elegant appearance, can be washed away by warm water at night, has no side effect, and does not generate any waste.

Furthermore, the instant nano mask can be added with various skin care, moisture retention and treatment components according to the preference of users, and a series of products are developed according to the requirements of different people, so that a specific effect is achieved.

Furthermore, the substrate of the instant nano mask and the skin care and treatment components in the instant nano mask exist in a nano scale, can be directly absorbed by skin, for example, trehalose has good functions of preventing cell dehydration and moisture retention, has excellent characteristic of keeping cell vitality, and prevents the skin cells from losing water and keratinizing under the environments of high temperature, high cold, dryness, strong ultraviolet rays and the like; papain can dissolve keratinized dandruff, and has good skin care and therapeutic effects.

Furthermore, spin nanometer facial mask promptly and block the harmful substance in the haze outside skin, play good and prevent the haze effect, protect user's health.

Furthermore, various beauty and make-up components can be added into the nano-mask to replace various cosmetics, so that the nano-mask is convenient for users to use and reduces the expenditure of the users.

Further, the moisture retention time of the instant nano mask is not less than 4 h.

Further, the moisture retention time of the instant nano mask is not less than 6 h.

The preparation method of the spinning nano facial mask comprises the step of spinning a homogeneous spinning solution containing a high-molecular substrate and a solvent on a glutinous rice paper to obtain the spinning nano facial mask.

Further, the preparation method comprises the following specific steps:

step 1, preparation of a spinning solution: mixing the polymer substrate and a solvent, and stirring at the constant temperature of 60-80 ℃ for more than 10 hours until the polymer substrate and the solvent are uniformly mixed, thus preparing the spinning solution;

step 2, preparing the spinning nano facial mask: and (2) placing the spinning solution obtained in the step (1) into an electrostatic spinning machine, setting parameters of the electrostatic spinning machine including system temperature, spinning solution flow rate, receiving distance and voltage, and uniformly spinning on glutinous rice paper or human skin for 8-12 min by using an electric spinning gun head of the electrostatic spinning machine to obtain the instant nano facial mask.

Further, after the polymer substrate and the solvent are uniformly mixed in the step 1, any one or any two or three of a skin care and moisture retention component, a cosmetic component and a beauty component are added, and stirring is continued until the skin care and moisture retention component, the polymer substrate and the solvent are uniformly mixed.

Further, the mass fraction of the polymer substrate ranges from 25% to 40%.

Further, the mass fraction of the solvent is in the range of 40% to 75%.

Further, after the polymer substrate and the solvent are uniformly mixed in the step 1, skin-care and moisture-retention components with the mass fraction of 1-5% are added, and stirring is continued until the skin-care and moisture-retention components, the polymer substrate and the solvent are uniformly mixed.

Further, in the step 1, the polymer substrate and the solvent are uniformly mixed, and then cosmetic ingredients with the mass fraction not more than 2% and/or cosmetic ingredients with the mass fraction not more than 2% are added.

Further, the cosmetic component is perfume and/or rose oil.

Further, the spinning time in the step 2 is preferably 5-10 min, the spinning time is too short, the thickness of the instant nano mask cannot reach a certain thickness, the spinning time is too long, and the instant nano mask is too compact.

Further, the temperature of the system in the step 2 is 25-40 ℃.

Further, the flow rate of the dope in the step 2 is 0.1 to 0.3 ml/h.

Further, in the step 2, the receiving distance is the distance between the electrostatic spinning gun and the glutinous rice paper, and the receiving distance is 5-8 cm.

Further, the voltage in the step 2 is 8 kv-20 kv.

The invention has the following beneficial technical effects:

(1) the instant nano mask has good moisture retention and air permeability, has natural appearance, can be used when going out, has the effects of skin care, moisture retention and haze prevention for a long time, and has better effect.

(2) The instant nano mask can be prepared by users at any time, is simple and convenient to prepare, can be used as daily cosmetics, has elegant and natural appearance, can be washed away by warm water at night, has no side effect and generates no waste.

(3) The instant nano mask can be added with various skin care, moisture retention and treatment components according to the preference of users, and develops a series of products aiming at the requirements of different crowds to achieve specific effects.

(4) The substrate of the instant nano facial mask and the skin care and treatment components in the substrate exist in a nano-scale, can be directly absorbed by skin, for example, trehalose has good functions of preventing cell dehydration and moisture preservation, has excellent characteristic of keeping cell activity, and prevents the skin cells from losing water and keratinizing under the environments of high temperature, high cold, dryness, strong ultraviolet rays and the like; papain can dissolve keratinized dandruff, and has good skin care and therapeutic effects.

(5) The instant nano mask disclosed by the invention can block harmful substances in haze out of skin, so that a good haze prevention effect is achieved, and the health of a user is protected.

(6) The instant nano facial mask can be added with various beauty and make-up components to replace various cosmetics, so that the instant nano facial mask is convenient for users to use and reduces the expenditure of the users.

Drawings

Fig. 1 is a Scanning Electron Microscope (SEM) image of a gelatin nano-mask in example 1 of the present invention.

Fig. 2 is a Scanning Electron Microscope (SEM) image of a gelatin + trehalose nanofilm in example 2 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

On the contrary, the invention is intended to cover alternatives, modifications, equivalents and alternatives which may be included within the spirit and scope of the invention as defined by the appended claims. Furthermore, in the following detailed description of the present invention, certain specific details are set forth in order to provide a better understanding of the present invention. It will be apparent to one skilled in the art that the present invention may be practiced without these specific details.

Example 1

The present example provides a method for preparing a spinning nano-mask, which is obtained by spinning a homogeneous dope containing a polymeric substrate and water on a wafer.

The preparation method comprises the following specific steps:

(1) selecting the spinning solution raw materials: selecting gelatin prepared from fish skin collagen as a high molecular substrate, and selecting deionized water as water;

(2) preparing a spinning solution: placing the gelatin and the deionized water in a 50ml volumetric flask according to the mass ratio of 1:2, mixing, stirring at the constant temperature of 60-80 ℃ for 12h until the gelatin and the deionized water are uniformly mixed, and adding the deionized water to a constant volume to prepare the spinning solution with the gelatin mass fraction of 33.3%;

(3) setting parameters of the electric spinning machine: the system temperature was 35 ℃, the dope flow rate was 0.2ml/h, the receiving distance was 8cm, and the voltage was 8 kv.

(4) Namely, preparing the nano-mask: and (3) placing the spinning solution obtained in the step (1) into an electrostatic spinning machine, and uniformly spinning on the glutinous rice paper for 8-12 min by using an electric spinning gun head of the electrostatic spinning machine to obtain the instant nano facial mask.

And carrying out a moisturizing test on the prepared instant nano facial mask to obtain that the moisturizing time is more than 4 h.

The structure of the nano-film was observed under a scanning electron microscope by using the instant nano-mask prepared by the preparation method of this example, as shown in fig. 1, the obtained gelatin nano-mask (nano-nonwoven) had a uniform, smooth and porous micro-morphology, and the fiber diameter was between 200nm and 400 nm.

Example 2

The preparation method of the instant nano mask is basically the same as that of the example 1, except that:

(2) when the spinning solution is prepared, after the gelatin and the deionized water are uniformly mixed, 2-3 drops of trehalose and 2-3 drops of osmanthus perfume are added, and the mixture is continuously stirred until all the components are uniformly mixed.

And carrying out a moisturizing test on the prepared instant nano facial mask to obtain that the moisturizing time is more than 6 h.

The structure of the nano-film was observed under a scanning electron microscope using the instant nano-mask, as shown in fig. 2, and the obtained gelatin nano-mask (nano-nonwoven) had a uniform, smooth, porous micro-morphology, a fiber diameter of 200nm to 400nm, and oval protrusions on the nano-fibers, including trehalose as a component.

Example 3

(2) the preparation process of the middle spinning solution comprises the following steps:

putting the gelatin and the deionized water into a 50ml volumetric flask according to the mass ratio of 1:2, mixing, stirring for 12 hours at a constant temperature of 60-80 ℃ until the gelatin and the deionized water are uniformly mixed, adding 3% trehalose and 1% osmanthus perfume, and continuously stirring until all components are uniformly mixed; at the moment, a gelatin solution with the mass fraction of 16.0% is prepared;

cutting silkworm cocoon with scissors, removing silkworm pupa, peeling silkworm cocoon into several layers, boiling in 0.5% sodium bicarbonate water solution (bath water ratio of 1: 100) for 30min, removing sericin on the surface of cocoon silk, and repeating the above steps twice. Then fully washing with deionized water, and finally airing. 10g of the degummed fibroin is taken, 9.5mol/L LiBr is used for preparing a solution with the concentration of 10 percent, and the solution is placed overnight. Adding deionized water for diluting by 5 times, filtering, pouring into a dialysis bag, and continuously dialyzing with deionized water until the conductivity of the deionized water outside the dialysis bag is basically unchanged;

and thirdly, weighing 8g of silk fibroin, dissolving the silk fibroin into the gelatin solution in the first step, and fixing the volume to 50mL to obtain the gelatin silk fibroin spinning solution.

The structure of the nano-film was observed under a scanning electron microscope by using the instant nano-mask prepared according to the preparation method of this example, and the obtained gelatin nano-mask (nano-nonwoven) had a uniform, smooth, porous micro-morphology, a fiber diameter of 200nm to 400nm, and oval protrusions on the nano-fibers, wherein the protrusions included trehalose as a component.

Claims

1. A preparation method of a spinning nano facial mask is characterized by comprising the following specific steps:

step 1, the preparation method of the spinning solution comprises the following steps: putting gelatin and deionized water into a 50ml volumetric flask according to the mass ratio of 1:2, mixing, stirring at the constant temperature of 60-80 ℃ for 12h until the gelatin and the deionized water are uniformly mixed, and adding deionized water to a constant volume to prepare the spinning solution with the gelatin mass fraction of 33.3%; after the gelatin and the deionized water are uniformly mixed, adding 2-3 drops of trehalose and 2-3 drops of osmanthus perfume, and continuously stirring until all the components are uniformly mixed;

the gelatin is fish skin gelatin;

step 2, preparing the spinning nano facial mask: placing the spinning solution obtained in the step 1 into an electric spinning machine, setting parameters of the electric spinning machine including system temperature, spinning solution flow rate, receiving distance and voltage, and uniformly spinning glutinous rice paper or human skin for 8-12 min by using a gun head of an electrostatic spinning gun of the electric spinning machine to obtain the instant spinning nano facial mask;

in the step 2, the system temperature is 25-40 ℃;

the flow rate of the spinning solution in the step 2 is 0.1 to 0.3 ml/h;

in the step 2, the receiving distance is the distance between the electrostatic spinning gun and the glutinous rice paper, and the receiving distance is 5-8 cm;

the voltage in the step 2 is 8 kv-20 kv.

2. The preparation method of the spinning nano facial mask as claimed in claim 1, wherein the diameter of the fiber of the spinning nano facial mask is 200 nm-400 nm.