CN113564075A - 用于治疗例如细菌性阴道病的鼠李糖乳杆菌细菌 - Google Patents

用于治疗例如细菌性阴道病的鼠李糖乳杆菌细菌 Download PDF

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Publication number
CN113564075A
CN113564075A CN202110848314.7A CN202110848314A CN113564075A CN 113564075 A CN113564075 A CN 113564075A CN 202110848314 A CN202110848314 A CN 202110848314A CN 113564075 A CN113564075 A CN 113564075A
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China
Prior art keywords
strain
lactobacillus
bpl005
lactobacillus rhamnosus
vaginal
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Pending
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CN202110848314.7A
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Chinese (zh)
Inventor
M·E·彻诺夸德罗斯
B·卡西诺斯拉莫
A·席尔瓦安古洛
D·拉蒙维达尔
S·赫诺韦斯马丁内斯
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Firelink Pharmaceuticals
Ferring BV
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Firelink Pharmaceuticals
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Publication of CN113564075A publication Critical patent/CN113564075A/zh
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/175—Rhamnosus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)
  • Inorganic Chemistry (AREA)
CN202110848314.7A 2015-06-29 2016-06-29 用于治疗例如细菌性阴道病的鼠李糖乳杆菌细菌 Pending CN113564075A (zh)

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EPEP15174222.8 2015-06-29
EP15174222 2015-06-29
CN201680036708.XA CN108076643B (zh) 2015-06-29 2016-06-29 用于治疗例如细菌性阴道病的鼠李糖乳杆菌细菌

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CN201680036708.XA Active CN108076643B (zh) 2015-06-29 2016-06-29 用于治疗例如细菌性阴道病的鼠李糖乳杆菌细菌

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US (2) US10588926B2 (enExample)
JP (1) JP6837015B2 (enExample)
KR (1) KR102713511B1 (enExample)
CN (2) CN113564075A (enExample)
AU (1) AU2016287200B2 (enExample)
CA (1) CA2989977A1 (enExample)
MX (1) MX383921B (enExample)
RU (1) RU2758109C2 (enExample)
WO (1) WO2017001440A1 (enExample)

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WO2017001440A1 (en) 2015-06-29 2017-01-05 Ferring B.V. Lactobacillus rhamnosus bacterium for treatment of e.g. bacterial vaginosis
EP3427745A1 (en) 2017-07-12 2019-01-16 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO New probiotic composition for prevention of bacterial vaginosis
CN108004188B (zh) * 2018-01-11 2020-02-14 广东龙创基药业有限公司 一种鼠李糖乳杆菌及其用于制备阴道抑菌药物的应用
RU2703708C1 (ru) * 2018-10-08 2019-10-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ прогнозирования степени риска нарушения микробиоты влагалища
US20230201281A1 (en) 2020-06-01 2023-06-29 Ferring B.V. Vaginal microbiota compositions
EP4165220B1 (en) * 2020-06-11 2024-07-03 ADM Denmark A/S Probiotic composition and uses thereof against candida infections
PT3939602T (pt) * 2020-07-14 2024-07-10 Probisearch S L U Estirpe de lactobacillus salivarus ps11610 e seu uso na prevenção e tratamento de disbiose do trato urogenital
KR102546934B1 (ko) 2021-04-02 2023-06-23 대한민국 락토바실러스 람노서스 kcc-51 균주 및 이를 포함하는 조성물
CN113287753A (zh) * 2021-05-24 2021-08-24 国珍健康科技（北京）有限公司 一种用于改善女性阴道炎症的益生菌组合物
CN115252655B (zh) * 2022-07-14 2023-06-16 金华银河生物科技有限公司 用于改善阴道炎症的益生菌后生元制品及制备方法和应用
CN115569154B (zh) * 2022-09-21 2024-06-11 微康益生菌(苏州)股份有限公司 防治念珠菌阴道炎的鼠李糖乳杆菌LRa05及其应用
CN118077903B (zh) * 2024-03-27 2024-09-17 瀚天生物(北京)科技有限公司 一种用于女性改善阴道紧致和水润环境的口服益生菌复合制剂及其制备方法与应用
WO2025210272A1 (en) * 2024-04-05 2025-10-09 Ferring B.V. Composition comprising lactobacillus species for vaginal therapies

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US20130171253A1 (en) * 2010-09-14 2013-07-04 Hso Health Care Gmbh Compositions for the vaginal and oral administration of lactobacillus and uses thereof
JP2014218491A (ja) * 2013-04-10 2014-11-20 国立大学法人広島大学 乳酸菌の菌体等、並びにこれらを含有する口腔内疾患の予防材等及び食品
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GR3024223T3 (en) * 1991-02-01 1997-10-31 Agronomique Inst Nat Rech Xylanase, xylanase-producing bacillus and applications thereof
US20020044926A1 (en) * 1999-12-10 2002-04-18 Gregor Reid Oral administration of lactobacillus for the treatment and prevention of urogenital infection
CN1556852A (zh) * 2001-09-20 2004-12-22 �����ɷ� 作为人体阴道中的益生微生物的乳酸产生细菌
US20040022775A1 (en) * 2002-04-15 2004-02-05 Gregor Reid Methods of treating viral infections in mammals
US20090028839A1 (en) * 2004-12-23 2009-01-29 Tchikindas Mikhail L Compositions and methods for the prophylaxis and treatment of vaginal infections
EP2216036A1 (en) * 2009-02-10 2010-08-11 Nestec S.A. Lactobacillus rhamnosus NCC4007, a probiotic mixture and weight control
US20130171253A1 (en) * 2010-09-14 2013-07-04 Hso Health Care Gmbh Compositions for the vaginal and oral administration of lactobacillus and uses thereof
US20150139969A1 (en) * 2012-07-09 2015-05-21 Probionov Use of thiosulfate to potentiate the anti-pathogenic effect of lactobacilli
JP2014218491A (ja) * 2013-04-10 2014-11-20 国立大学法人広島大学 乳酸菌の菌体等、並びにこれらを含有する口腔内疾患の予防材等及び食品

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Title
钟燕等: "鼠李糖乳杆菌GR-1和罗伊氏乳杆菌RC-14防治阴道炎的研究进展", 《国际妇产科学杂志》, no. 5, pages 39 - 42 *

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MX383921B (es) 2025-03-14
US10588926B2 (en) 2020-03-17
RU2017143465A3 (enExample) 2019-11-20
CN108076643B (zh) 2021-09-21
JP6837015B2 (ja) 2021-03-03
KR102713511B1 (ko) 2024-10-04
CN108076643A (zh) 2018-05-25
CA2989977A1 (en) 2017-01-05
US11202813B2 (en) 2021-12-21
US20180228850A1 (en) 2018-08-16
WO2017001440A1 (en) 2017-01-05
MX2017016748A (es) 2018-11-09
US20200268815A1 (en) 2020-08-27
KR20180021777A (ko) 2018-03-05
AU2016287200B2 (en) 2020-09-17
RU2017143465A (ru) 2019-08-01
RU2758109C2 (ru) 2021-10-26
AU2016287200A1 (en) 2018-01-18
JP2018520677A (ja) 2018-08-02

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