CN113520941A - Moisturizing and repairing composition and preparation method thereof - Google Patents
Moisturizing and repairing composition and preparation method thereof Download PDFInfo
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- CN113520941A CN113520941A CN202110799854.0A CN202110799854A CN113520941A CN 113520941 A CN113520941 A CN 113520941A CN 202110799854 A CN202110799854 A CN 202110799854A CN 113520941 A CN113520941 A CN 113520941A
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 58
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 244000022198 Mirabilis jalapa Species 0.000 claims abstract description 72
- 235000009053 Mirabilis jalapa Nutrition 0.000 claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 58
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 45
- 241001571466 Potentilla discolor Species 0.000 claims abstract description 42
- 239000008367 deionised water Substances 0.000 claims abstract description 41
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 41
- 230000008439 repair process Effects 0.000 claims abstract description 41
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 30
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 15
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 15
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 15
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 15
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims abstract description 15
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims abstract description 15
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 15
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 15
- 229960000458 allantoin Drugs 0.000 claims abstract description 15
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 15
- 229940073499 decyl glucoside Drugs 0.000 claims abstract description 15
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 15
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims abstract description 15
- 235000012209 glucono delta-lactone Nutrition 0.000 claims abstract description 15
- 229960003681 gluconolactone Drugs 0.000 claims abstract description 15
- 229940070765 laurate Drugs 0.000 claims abstract description 15
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 9
- 238000000605 extraction Methods 0.000 claims description 56
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 42
- 239000000843 powder Substances 0.000 claims description 39
- 108090000790 Enzymes Proteins 0.000 claims description 31
- 102000004190 Enzymes Human genes 0.000 claims description 31
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 18
- 240000000103 Potentilla erecta Species 0.000 claims description 17
- 235000016551 Potentilla erecta Nutrition 0.000 claims description 17
- 238000001035 drying Methods 0.000 claims description 17
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 15
- 238000004140 cleaning Methods 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 13
- 108010059820 Polygalacturonase Proteins 0.000 claims description 9
- 239000012752 auxiliary agent Substances 0.000 claims description 9
- 230000002255 enzymatic effect Effects 0.000 claims description 9
- 108010093305 exopolygalacturonase Proteins 0.000 claims description 9
- 239000000413 hydrolysate Substances 0.000 claims description 9
- 239000002131 composite material Substances 0.000 claims description 7
- 230000002779 inactivation Effects 0.000 claims description 7
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical group CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000002002 slurry Substances 0.000 claims description 7
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 6
- 102100022624 Glucoamylase Human genes 0.000 claims description 6
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 6
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- 102000006995 beta-Glucosidase Human genes 0.000 claims description 5
- 108010047754 beta-Glucosidase Proteins 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 244000025254 Cannabis sativa Species 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 22
- 230000008591 skin barrier function Effects 0.000 abstract description 10
- 230000000638 stimulation Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 23
- 230000000052 comparative effect Effects 0.000 description 21
- 238000012360 testing method Methods 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- -1 alkyl glycoside Chemical class 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 238000003809 water extraction Methods 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229940048848 lauryl glucoside Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a moisturizing repair composition and a preparation method thereof, wherein the moisturizing repair composition comprises the following components in parts by weight: 0.08-0.2 part of hydrolyzed sclerotium rolfsii gum, 0.15-0.3 part of gluconolactone, 0.2-0.5 part of tocopherol acetate, 0.3-0.6 part of dipotassium glycyrrhizinate, 0.3-0.6 part of allantoin, 0.4-0.7 part of potentilla discolor extract, 0.6-1 part of trehalose, 0.8-1.2 parts of mirabilis jalapa extract, 1-1.5 parts of polyglycerol-10 laurate, 2-4 parts of decyl glucoside, 7-12 parts of glycerol and 75-90 parts of deionized water. The moisturizing and repairing composition provided by the invention has good moisturizing and repairing effects, can effectively repair skin barriers, can effectively relieve skin, repair the balance of internal and external elements of the skin, promote the skin to be free from external stimulation, and strengthen the safety protection of the skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a moisturizing and repairing composition and a preparation method thereof.
Background
Skin moisturization is the basis for skin care. The natural moisture barrier of the human body plays an important role in moisturizing the skin and storing water. The effect of skin moisturizing can be achieved by an exogenous moisturizing method. The quality of the skin moisture retention can reflect the normality or normality of the skin barrier function. The reduced skin moisturizing ability results in a reduced skin barrier function that further reduces the skin moisturizing ability, causing a vicious circle. Therefore, moisturizing is the basis and key of skin care, and the reduction of the skin moisturizing function can cause various skin problems, which are the bottom layer of the skin care pyramid and the basis of skin care.
The skin epidermis barrier is composed of a skin surface stratum corneum keratin and intercellular lipid to form a brick wall structure, dermis mucopolysaccharide, mucopolysaccharide and the like, and resists the entrance of external harmful and irritants.
Disclosure of Invention
The moisturizing and repairing composition has good moisturizing and repairing effects and can effectively repair skin barriers.
The invention adopts the following technical scheme for solving the technical problems:
a moisturizing repair composition comprises the following components in parts by weight: 0.08-0.2 part of hydrolyzed sclerotium rolfsii gum, 0.15-0.3 part of gluconolactone, 0.2-0.5 part of tocopherol acetate, 0.3-0.6 part of dipotassium glycyrrhizinate, 0.3-0.6 part of allantoin, 0.4-0.7 part of potentilla discolor extract, 0.6-1 part of trehalose, 0.8-1.2 parts of mirabilis jalapa extract, 1-1.5 parts of polyglycerol-10 laurate, 2-4 parts of decyl glucoside, 7-12 parts of glycerol and 75-90 parts of deionized water.
The moisturizing repair composition disclosed by the invention is reasonable in formula matching, has good moisturizing and repair effects, and can effectively repair skin barriers.
As a preferable scheme, the moisturizing repair composition comprises the following components in parts by weight: 0.08-0.15 part of hydrolyzed sclerotium rolfsii gum, 0.15-0.25 part of gluconolactone, 0.3-0.5 part of tocopherol acetate, 0.4-0.6 part of dipotassium glycyrrhizinate, 0.4-0.6 part of allantoin, 0.5-0.7 part of potentilla discolor extract, 0.6-0.9 part of trehalose, 0.8-1.1 part of mirabilis jalapa extract, 1-1.4 parts of polyglycerol-10 laurate, 2.5-4 parts of decyl glucoside, 8-12 parts of glycerol and 75-85 parts of deionized water.
As a preferable scheme, the moisturizing repair composition comprises the following components in parts by weight: 0.1 part of hydrolyzed sclerotium rolfsii gum, 0.2 part of gluconolactone, 0.4 part of tocopherol acetate, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 0.6 part of potentilla discolor extract, 0.8 part of trehalose, 1 part of mirabilis jalapa extract, 1.2 parts of polyglycerol-10 laurate, 3 parts of decyl glucoside, 10 parts of glycerol and 81.7 parts of deionized water.
The inventor of the invention finds that the moisturizing and repairing composition has the best moisturizing and repairing effects under the weight ratio.
As a preferable scheme, the preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 50-80 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, uniformly mixing to obtain slurry, adding complex enzyme and CTAB, reacting for 4-10 h at 45-60 ℃, heating to 80-95 ℃, and keeping the temperature for 6-12 min for inactivation to obtain enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 5-10: 0.02-0.05: 0.005-0.015;
s03, adding the enzymatic hydrolysate into an extraction kettle for extraction to obtain an extract, and drying to obtain the mirabilis jalapa extract.
Preferably, the complex enzyme is prepared from beta-glucosidase, pectinase and glucoamylase according to a weight ratio of 1: 0.5-2: 0.5 to 2.
The inventor of the invention finds that the mirabilis jalapa extract with good repairing effect is obtained through crushing, enzymolysis and supercritical extraction, and can effectively repair the skin barrier.
The inventor finds that in the preparation process of the mirabilis jalapa extract, the dissolution of components with repair effect of the mirabilis jalapa can be effectively promoted by enzymolysis of the complex enzyme and the CTAB, and the subsequent supercritical extraction is facilitated.
As a preferred scheme, the pressure of supercritical extraction is 20-28 Mpa, the extraction temperature is 50-65 ℃, the extraction time is 80-120 min, and CO is added2The flow rate of the fluid is 15-25 kg/h.
As a preferred scheme, the preparation method of the potentilla discolor extract comprises the following steps:
s11, cleaning the potentilla discolor whole grass, drying, and crushing to 60-100 meshes to obtain potentilla discolor powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 40-80 min, heating to 55-70 ℃, and preserving heat for 80-150 min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.02-0.06: 6 to 10.
S13, adding the extracting solution and the auxiliary agent into an extraction kettle for extraction to obtain an extract, and drying to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.01 to 0.04;
the supercritical extraction pressure is 30-35 Mpa, the extraction temperature is 45-55 ℃, the extraction time is 100-200 min, and CO is added2The flow rate of the fluid is 20-28 kg/h.
The inventor of the invention finds that the potentilla discolor extract with good repairing effect can be obtained by adopting crushing, acid-assisted water extraction and alkyl glycoside-assisted extraction in the process of extracting a large amount of potentilla discolor.
As a preferable embodiment, the auxiliary is dodecyl glucoside.
The invention also provides a preparation method of the moisturizing and repairing composition, which comprises the following steps:
adding hydrolyzed sclerotium rolfsii gum, dipotassium glycyrrhizinate and polyglycerol-10 laurate into glycerol, heating to 55-70 ℃, uniformly stirring, adding deionized water, uniformly stirring, cooling to 38-45 ℃, adding gluconolactone, tocopheryl acetate, allantoin, potentilla discolor extract, trehalose, mirabilis jalapa extract and decyl glucoside, and uniformly stirring to obtain the moisturizing repair composition.
The invention also provides an application of the moisturizing and repairing composition prepared in the preparation of moisturizing and repairing cosmetics.
The invention has the beneficial effects that: the moisturizing and repairing composition has good moisturizing and repairing effects, can effectively repair skin barriers, can effectively relieve skin, repair the balance of elements inside and outside the skin, promote the skin to be free from external stimulation and enhance the safety protection of the skin.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A moisturizing repair composition comprises the following components in parts by weight: 0.1 part of hydrolyzed sclerotium rolfsii gum, 0.2 part of gluconolactone, 0.4 part of tocopherol acetate, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 0.6 part of potentilla discolor extract, 0.8 part of trehalose, 1 part of mirabilis jalapa extract, 1.2 parts of polyglycerol-10 laurate, 3 parts of decyl glucoside, 10 parts of glycerol and 81.7 parts of deionized water.
The preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 60 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, mixing uniformly to obtain slurry, adding complex enzyme and CTAB, reacting at 55 ℃ for 6h, heating to 85 ℃, and keeping the temperature for 10min for inactivation to obtain enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 8: 0.045: 0.01;
s03, adding the enzymolysis liquid into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 25Mpa,the extraction temperature is 60 ℃, the extraction time is 100min, and CO is added2The flow rate of the fluid is 20kg/h to obtain the extract, and the extract is dried to obtain the mirabilis jalapa extract.
The compound enzyme is prepared from beta-glucosidase, pectinase and glucoamylase according to a weight ratio of 1: 1: 1.
The preparation method of the potentilla discolor extract comprises the following steps:
s11, cleaning the discolor cinquefoil herb, drying, and crushing to 80 meshes to obtain discolor cinquefoil herb powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 50min, heating to 60 ℃, and preserving heat for 120min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.05: 9.
s13, adding the extracting solution and dodecyl glucoside into an extraction kettle for extraction, wherein the supercritical extraction pressure is 32Mpa, the extraction temperature is 50 ℃, the extraction time is 150min, and CO is2The flow rate of the fluid is 25kg/h to obtain an extract, and the extract is dried to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.03.
the preparation method of the moisturizing and repairing composition comprises the following steps:
adding hydrolyzed sclerotium rolfsii gum, dipotassium glycyrrhizinate and polyglycerol-10 laurate into glycerol, heating to 60 ℃, uniformly stirring at the rotating speed of 400rpm, adding deionized water, uniformly stirring at the rotating speed of 500rpm, cooling to 40 ℃, adding gluconolactone, tocopheryl acetate, allantoin, potentilla discolor extract, trehalose, mirabilis jalapa extract and decyl glucoside, and uniformly stirring at the rotating speed of 200rpm to obtain the moisturizing repair composition.
In the preparation process of the mirabilis jalapa extract, the components with the repairing effect of the mirabilis jalapa can be effectively promoted to be dissolved out through enzymolysis of the complex enzyme and the CTAB, the subsequent supercritical extraction is facilitated, other enzymes are adopted to compositely replace the complex enzyme and the CTAB, the repairing effect of the obtained mirabilis jalapa can be obviously reduced, namely, the mirabilis jalapa extract with the good repairing effect can be obtained only by matching the complex enzyme with the CTAB.
The potentilla discolor extract with good repairing effect can be obtained by adopting crushing, acid-assisted water extraction and alkyl glycoside-assisted extraction.
Example 2
A moisturizing repair composition comprises the following components in parts by weight: 0.12 part of hydrolyzed sclerotium rolfsii gum, 0.3 part of gluconolactone, 0.5 part of tocopheryl acetate, 0.3 part of dipotassium glycyrrhizinate, 0.6 part of allantoin, 0.4 part of potentilla discolor extract, 1 part of trehalose, 0.8 part of mirabilis jalapa extract, 1.5 parts of polyglycerol-10 laurate, 4 parts of decyl glucoside, 7 parts of glycerol and 83.48 parts of deionized water.
The preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 80 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, mixing uniformly to obtain slurry, adding complex enzyme and CTAB, reacting at 50 ℃ for 5h, heating to 80 ℃, and keeping the temperature for 12min for inactivation to obtain enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 6: 0.03: 0.01;
s03, adding the enzymolysis liquid into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 22Mpa, the extraction temperature is 55 ℃, the extraction time is 90min, and CO is used for extracting2The flow rate of the fluid is 18kg/h to obtain the extract, and the extract is dried to obtain the mirabilis jalapa extract.
The compound enzyme is prepared from beta-glucosidase, pectinase and glucoamylase according to a weight ratio of 1: 1.2: 0.8.
The preparation method of the potentilla discolor extract comprises the following steps:
s11, cleaning the potentilla discolor whole grass, drying, and crushing to 100 meshes to obtain potentilla discolor powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 70min, heating to 58 ℃, and preserving heat for 100min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.03: 8.
s13, adding the extract and dodecyl glucoside into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 30Mpa, the extraction temperature is 48 DEG CExtraction time of 120min, CO2The flow rate of the fluid is 24kg/h to obtain an extract, and the extract is dried to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.03.
the preparation method of the moisturizing and repairing composition comprises the following steps:
adding hydrolyzed sclerotium rolfsii gum, dipotassium glycyrrhizinate and polyglycerol-10 laurate into glycerol, heating to 60 ℃, uniformly stirring at the rotating speed of 400rpm, adding deionized water, uniformly stirring at the rotating speed of 500rpm, cooling to 40 ℃, adding gluconolactone, tocopheryl acetate, allantoin, potentilla discolor extract, trehalose, mirabilis jalapa extract and decyl glucoside, and uniformly stirring at the rotating speed of 200rpm to obtain the moisturizing repair composition.
Example 3
A moisturizing repair composition comprises the following components in parts by weight: 0.08 part of hydrolyzed sclerotium rolfsii gum, 0.15 part of gluconolactone, 0.2 part of tocopherol acetate, 0.6 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 0.6 part of potentilla discolor extract, 0.9 part of trehalose, 0.9 part of mirabilis jalapa extract, 1 part of polyglycerol-10 laurate, 3.5 parts of decyl glucoside, 11 parts of glycerol and 80.57 parts of deionized water.
The preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 50 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, mixing uniformly to obtain slurry, adding complex enzyme and CTAB, reacting at 60 ℃ for 7h, heating to 85 ℃, and keeping the temperature for 10min for inactivation to obtain enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 8: 0.02: 0.01;
s03, adding the enzymolysis liquid into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 25Mpa, the extraction temperature is 60 ℃, the extraction time is 100min, and CO is used for extraction2The flow rate of the fluid is 20kg/h to obtain the extract, and the extract is dried to obtain the mirabilis jalapa extract.
The compound enzyme is prepared from beta-glucosidase, pectinase and glucoamylase according to a weight ratio of 1: 0.6: 1.4.
The preparation method of the potentilla discolor extract comprises the following steps:
s11, cleaning the potentilla discolor whole grass, drying, and crushing to 60 meshes to obtain potentilla discolor powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 50min, heating to 62 ℃, and preserving heat for 100min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.04: 8.
s13, adding the extracting solution and dodecyl glucoside into an extraction kettle for extraction, wherein the supercritical extraction pressure is 30Mpa, the extraction temperature is 48 ℃, the extraction time is 120min, and CO is2The flow rate of the fluid is 24kg/h to obtain an extract, and the extract is dried to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.03.
the preparation method of the moisturizing and repairing composition comprises the following steps:
adding hydrolyzed sclerotium rolfsii gum, dipotassium glycyrrhizinate and polyglycerol-10 laurate into glycerol, heating to 60 ℃, uniformly stirring at the rotating speed of 400rpm, adding deionized water, uniformly stirring at the rotating speed of 500rpm, cooling to 40 ℃, adding gluconolactone, tocopheryl acetate, allantoin, potentilla discolor extract, trehalose, mirabilis jalapa extract and decyl glucoside, and uniformly stirring at the rotating speed of 200rpm to obtain the moisturizing repair composition.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain the Mirabilis jalapa extract, and the rest are the same.
Comparative example 2
Comparative example 2 is different from example 1 in that the preparation method of the mirabilis jalapa extract in the comparative example 2 is different from example 1, and in the comparative example, single pectinase is adopted to replace the complex enzyme and CTAB, and the rest are the same.
The preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 60 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, uniformly mixing to obtain a slurry, adding pectinase, reacting for 6 hours at 55 ℃, heating to 85 ℃, and keeping the temperature for 10min for inactivation to obtain an enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 8: 0.055;
s03, adding the enzymolysis liquid into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 25Mpa, the extraction temperature is 60 ℃, the extraction time is 100min, and CO is used for extraction2The flow rate of the fluid is 20kg/h to obtain the extract, and the extract is dried to obtain the mirabilis jalapa extract.
Comparative example 3
Comparative example 3 is different from example 1 in that the preparation method of the mirabilis jalapa extract in the comparative example 3 is different from example 1, and in the comparative example, a compound enzyme consisting of pectinase and saccharifying enzyme is used to replace the compound enzyme and CTAB in the example 1, and the rest is the same.
The preparation method of the mirabilis jalapa extract comprises the following steps:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 60 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, mixing uniformly to obtain slurry, adding a complex enzyme, reacting at 55 ℃ for 6h, heating to 85 ℃, and keeping the temperature for 10min for inactivation to obtain an enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 8: 0.055;
s03, adding the enzymolysis liquid into an extraction kettle for extraction, wherein the pressure of the supercritical extraction is 25Mpa, the extraction temperature is 60 ℃, the extraction time is 100min, and CO is used for extraction2The flow rate of the fluid is 20kg/h to obtain the extract, and the extract is dried to obtain the mirabilis jalapa extract.
The compound enzyme is prepared from pectinase and glucoamylase according to a weight ratio of 1: 1.
Comparative example 4
Comparative example 4 is different from example 1 in that comparative example 1 does not contain the potentilla discolor extract, and the others are the same.
Comparative example 5
Comparative example 5 is different from example 1 in that the method for preparing the potentilla discolor extract described in comparative example 5 is different from example 1 in that citric acid is not used in S12 and an adjuvant (lauryl glucoside) is not used in S13, all of which are the same.
The preparation method of the potentilla discolor extract comprises the following steps:
s11, cleaning the discolor cinquefoil herb, drying, and crushing to 80 meshes to obtain discolor cinquefoil herb powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 50min, heating to 60 ℃, and preserving heat for 120min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.05: 9.
s13, adding the extracting solution and dodecyl glucoside into an extraction kettle for extraction, wherein the supercritical extraction pressure is 32Mpa, the extraction temperature is 50 ℃, the extraction time is 150min, and CO is2The flow rate of the fluid is 25kg/h to obtain an extract, and the extract is dried to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.03.
to further demonstrate the effect of the present invention, the following test methods were provided:
1. 10 healthy women with age of 25-30 years without skin diseases are selected as test subjects, test areas (area 5cm × 5 cm) are determined on the left and right front arms of 70 test subjects, and the skin moisture content of the test areas of the test subjects is tested by using a skin stratum corneum moisture content tester (high-frequency conductivity tester Skicon 200), which is an initial value. After the moisturizing repair composition described in examples 1 to 3 was used correspondingly (2, 4, 6, 8 hours), the moisture content in the test area was measured by the same instrument and method, and the measurement results are test values, and the moisture content increase rate was calculated and shown in table 1.
The water content increase rate (%) was (test value water content-initial value water content)/initial value water content × 100%
TABLE 1 Water cut growth Rate
As can be seen from table 1, the moisturizing repair composition of the present invention has good moisturizing effect, wherein the moisturizing repair composition described in example 1 has the best moisturizing effect.
2. Change of skin moisture loss
Selecting 40 volunteers, dividing the volunteers into 8 groups, and detecting skin barrier function of 5 groups (respectively using the moisturizing repair compositions described in subsequent examples 1-3 and comparative examples 1-5): the transcutaneous water loss (TEWL) was measured using the German CK company multi-probe skin test system MPA9, CM825 (moisture test probe) and TM300 (moisture loss test probe). The measurement is carried out under the conditions of constant temperature and constant humidity, a tested person cleans the skin to be tested before the detection and enters the testing environment for quiet test 30min in advance, and the testing supplementary positions are the left front arm and the right front arm.
The area under test (5 cm. times.5 cm) was marked 5cm inside the subject's arm from the base of the palm, and the same arm was marked 3 areas simultaneously (5 cm apart). The blank value of each test area is measured, and then the test sample is measured according to the ratio of 2.0mg/cm2The amount of the moisture-preserving repair composition is used for single coating (the moisture-preserving repair composition described in examples 1-3 and comparative examples 1-5), after 2 hours of coating, the water loss rate is tested by using the instrument, the average value is calculated, and the test result is shown in table 2.
The skin water dispersion loss reflects the change rule of the water dispersion of an experimental area along with time in a test period, and can represent the skin barrier repair function of a test sample, and the smaller the value of the water dispersion loss is, the less the water dispersion is, the stronger the skin repair capability is; conversely, the weaker the skin-repairing ability.
Water loss (%) - (sample component water dispersion-initial water dispersion)/initial water dispersion × 100%.
TABLE 2 Water loss
As can be seen from table 2, the moisturizing repair composition of the present invention has a good repairing effect and can effectively repair the skin barrier.
Compared with the examples 1 to 3, the repairing effect can be effectively improved by optimizing the proportion of the moisturizing and repairing composition and the preparation parameters of the mirabilis jalapa extract and the discolor cinquefoil extract, wherein the example 1 has the best repairing effect.
Compared with the comparative examples 1 and 1-3, the Mirabilis jalapa extract prepared by the method can effectively improve the repairing effect, and in the preparation method of the Mirabilis jalapa extract, if the complex enzyme and the CTAB are replaced by other enzymes, the repairing effect of the obtained Mirabilis jalapa extract is remarkably reduced, and the Mirabilis jalapa extract with good repairing effect can be obtained only by combining the complex enzyme and the CTAB.
Comparing example 1 with comparative examples 4 and 5, it can be seen that the potentilla discolor extract prepared by the invention can significantly improve the repairing effect, and the citric acid and the auxiliary agent are added in the preparation process to significantly improve the repairing effect of the potentilla discolor extract.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The moisturizing repair composition is characterized by comprising the following components in parts by weight: 0.08-0.2 part of hydrolyzed sclerotium rolfsii gum, 0.15-0.3 part of gluconolactone, 0.2-0.5 part of tocopherol acetate, 0.3-0.6 part of dipotassium glycyrrhizinate, 0.3-0.6 part of allantoin, 0.4-0.7 part of potentilla discolor extract, 0.6-1 part of trehalose, 0.8-1.2 parts of mirabilis jalapa extract, 1-1.5 parts of polyglycerol-10 laurate, 2-4 parts of decyl glucoside, 7-12 parts of glycerol and 75-90 parts of deionized water.
2. The moisturizing repair composition of claim 1, comprising, in parts by weight: 0.08-0.15 part of hydrolyzed sclerotium rolfsii gum, 0.15-0.25 part of gluconolactone, 0.3-0.5 part of tocopherol acetate, 0.4-0.6 part of dipotassium glycyrrhizinate, 0.4-0.6 part of allantoin, 0.5-0.7 part of potentilla discolor extract, 0.6-0.9 part of trehalose, 0.8-1.1 part of mirabilis jalapa extract, 1-1.4 parts of polyglycerol-10 laurate, 2.5-4 parts of decyl glucoside, 8-12 parts of glycerol and 75-85 parts of deionized water.
3. The moisturizing repair composition of claim 1, comprising, in parts by weight: 0.1 part of hydrolyzed sclerotium rolfsii gum, 0.2 part of gluconolactone, 0.4 part of tocopherol acetate, 0.5 part of dipotassium glycyrrhizinate, 0.5 part of allantoin, 0.6 part of potentilla discolor extract, 0.8 part of trehalose, 1 part of mirabilis jalapa extract, 1.2 parts of polyglycerol-10 laurate, 3 parts of decyl glucoside, 10 parts of glycerol and 81.7 parts of deionized water.
4. The moisturizing and repairing composition of claim 1, wherein the mirabilis jalapa extract is prepared by a method comprising:
s01, cleaning the whole mirabilis jalapa, drying, and crushing to 50-80 meshes to obtain mirabilis jalapa powder;
s02, adding mirabilis jalapa powder into deionized water, uniformly mixing to obtain slurry, adding complex enzyme and CTAB, reacting for 4-10 h at 45-60 ℃, heating to 80-95 ℃, and keeping the temperature for 6-12 min for inactivation to obtain enzymatic hydrolysate; the weight ratio of the mirabilis jalapa powder to the deionized water to the composite enzyme to the CTAB is 1: 5-10: 0.02-0.05: 0.005-0.015;
s03, adding the enzymatic hydrolysate into an extraction kettle for extraction to obtain an extract, and drying to obtain the mirabilis jalapa extract.
5. The moisturizing and repairing composition as claimed in claim 4, wherein the complex enzyme is prepared from beta-glucosidase, pectinase and glucoamylase according to a weight ratio of 1: 0.5-2: 0.5 to 2.
6. The moisturizing and repairing composition as claimed in claim 4, wherein the supercritical extraction pressure is 20-28 Mpa, the extraction temperature is 50-65 ℃, the extraction time is 80-120 min, and CO is added2The flow rate of the fluid is 15-25 kg/h.
7. The moisturizing repair composition of claim 1, wherein the potentilla discolor extract is prepared by a method comprising:
s11, cleaning the potentilla discolor whole grass, drying, and crushing to 60-100 meshes to obtain potentilla discolor powder;
s12, adding the discolor cinquefoil herb powder and the citric acid into deionized water, soaking for 40-80 min, heating to 55-70 ℃, and preserving heat for 80-150 min to obtain an extracting solution; the weight ratio of the discolor cinquefoil herb powder to the citric acid to the deionized water is 1: 0.02-0.06: 6 to 10.
S13, adding the extracting solution and the auxiliary agent into an extraction kettle for extraction to obtain an extract, and drying to obtain the potentilla discolor extract; the weight ratio of the extracting solution to the auxiliary agent is 1: 0.01 to 0.04;
the supercritical extraction pressure is 30-35 Mpa, the extraction temperature is 45-55 ℃, the extraction time is 100-200 min, and CO is added2The flow rate of the fluid is 20-28 kg/h;
the moisturizing repair composition of claim 7, wherein the adjuvant is dodecyl glucoside.
9. The preparation method of the moisturizing repair composition according to any one of claims 1 to 8, comprising the following steps:
adding hydrolyzed sclerotium rolfsii gum, dipotassium glycyrrhizinate and polyglycerol-10 laurate into glycerol, heating to 55-70 ℃, uniformly stirring, adding deionized water, uniformly stirring, cooling to 38-45 ℃, adding gluconolactone, tocopheryl acetate, allantoin, potentilla discolor extract, trehalose, mirabilis jalapa extract and decyl glucoside, and uniformly stirring to obtain the moisturizing repair composition.
10. Use of the moisturizing repair composition prepared according to claim 9 for preparing a moisturizing repair cosmetic.
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Effective date of registration: 20221227 Address after: 301, No. 6, Xinghong Second Street, Pingshan Second Village, Shibi Street, Panyu District, Guangzhou, Guangdong 510000 Applicant after: Guangzhou Zhongnuo Biotechnology Co.,Ltd. Address before: 510000 3307, No. 6, Xinghong Second Street (office building 1), Pingshan Second Village Industrial Zone, Shibi street, Panyu District, Guangzhou City, Guangdong Province Applicant before: Guangdong Renault cosmetics Research Institute Co.,Ltd. |
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