CN116889539A - Composition for relieving and resisting allergy, and preparation method and application thereof - Google Patents
Composition for relieving and resisting allergy, and preparation method and application thereof Download PDFInfo
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- CN116889539A CN116889539A CN202310497365.9A CN202310497365A CN116889539A CN 116889539 A CN116889539 A CN 116889539A CN 202310497365 A CN202310497365 A CN 202310497365A CN 116889539 A CN116889539 A CN 116889539A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention relates to the technical field of cosmetics, in particular to a composition for relieving and resisting allergy, and a preparation method and application thereof. The composition for relieving and resisting allergy of the invention comprises 0.5-2.0 parts of ginseng extract, 0.5-2.5 parts of discolor cinquefoil herb extract, 0.5-2.2 parts of rhizoma paridis extract, 0.2-1.5 parts of coptis chinensis extract, 0.1-1.2 parts of licorice extract and 0.6-3.0 parts of Gymnema sylvestre extract, and has excellent effects of relieving and resisting allergy and smoothing skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition for relieving and resisting allergy, and a preparation method and application thereof.
Background
Skin allergy is also called hypersensitivity, which means that a specific immune response, also called allergy, occurs when the body is stimulated by some specific antigen. Skin allergy reaction occurs, skin telangiectasis, permeability increase, tissue degeneration necrosis and the like can occur, and skin can generate symptoms such as itching, redness, swelling, desquamation and the like. Skin allergy is classified into four types according to reaction mechanism and clinical characteristics. In the field of skin care products, skin allergies are of the type I hypersensitivity.
The main cause of sensitive muscles is: 1. the skin barrier is damaged, the percutaneous water loss is increased, the water content of the stratum corneum is low, external causes are used for damaging the barrier function of the skin, and external stimulation factors are easier to enter the skin to cause allergic reaction of the skin; 2. the nerve growth content is high, the nerve reactivity is high when the nerve growth is stimulated by the outside, and allergic reaction is easy to occur; 3. inflammatory reactions, which are more difficult to resist invasion of external stimuli and allergens than normal skin due to the characteristics of damage of barrier function or abnormal nerve function of sensitive skin, are liable to occur a series of skin inflammatory reactions caused by stimuli or allergies, thereby further damaging the skin barrier structure and nerve endings, resulting in malignant circulation.
Therefore, there is a need to develop a composition for relieving and anti-sensitization with high efficiency and cosmetics thereof.
Disclosure of Invention
The invention is based on the technical problem and solves the technical problem, so that a composition for relieving and resisting allergy is provided, and the composition provides excellent effect of relieving and resisting allergy and has the effect of smoothing skin.
In one aspect, the soothing anti-allergic composition of the present invention comprises ginseng extract, discolor cinquefoil herb extract, paris polyphylla extract, coptis extract, licorice extract and Gymnema sylvestre extract.
Preferably, the soothing anti-allergic composition contains 0.5 to 2.0 parts by mass of ginseng extract. More preferably 0.6 to 1.9 parts, 0.7 to 1.8 parts, 0.8 to 1.7 parts, 0.9 to 1.7 parts, 1.0 to 1.5 parts. The ginseng extract has excellent effect of delaying skin aging and can moisten skin. The ginseng contains various ginsenoside, amino acids, vitamins and minerals, and has effects of promoting blood circulation of subcutaneous capillary vessel, enhancing cell activity, and promoting collagen activity. Phloretin in ginseng can also effectively promote the elasticity of the muscle base, reduce deep wrinkles, improve loose skin, promote skin contour and tighten sense. The ginseng extract or the leaching solution contains various saponins and polysaccharide components, has good permeability, can deeply moisten skin, nourish the skin, and quickly regulate the skin moisture balance. Suitable ginseng extracts may be derived from Hunan green and vines biotechnology Co.
Preferably, the soothing anti-allergic composition contains 0.5-2.5 parts by mass of discolor cinquefoil herb extract. More preferably 0.6 to 2.4 parts, 0.7 to 2.3 parts, 0.8 to 2.3 parts, 0.9 to 2.0 parts, 1.0 to 2.0 parts. Potentilla discolor is a plant of Rosaceae. Perennial herbs, root hypertrophy, coniform. The stems stand upright, and grey-white cotton wool is densely grown. Single feathered compound leaves. The basal leaves have 8-11 pairs of leaflets, the top leaflet is the largest, the two sides are smaller She Xiangxia gradually, the two sides are smaller She Xiachang oval, the chemical book is 2-5 cm long, the width is 8-15 mm, and the edge is feathered and deep-cracked. Can be used for treating dysentery, abdominal pain, chronic dysentery, hemorrhoid hemorrhage, carbuncle, swelling, and sore. The extract has effects of clearing heat, removing toxic substances, relieving dysentery and stopping bleeding. The discolor cinquefoil herb extract has excellent effects of resisting aging, removing wrinkles, preserving moisture and locking water and repairing skin. Suitable potentilla discolor extracts may be derived from the Sichuan Runbao Biotechnology Co.
Preferably, the soothing anti-allergic composition contains 0.5-2.2 parts by mass of paris polyphylla extract. More preferably 0.6 to 2.1 parts, 0.7 to 2.1 parts, 0.8 to 2.0 parts, 0.9 to 1.9 parts, 1.0 to 1.7 parts. Rhizoma paridis has effects of clearing heat and detoxicating, detumescence and relieving pain, cooling liver and arresting convulsion, resisting bacteria and inflammation, and resisting cancer, and can be used for treating diseases such as liver fire exuberance, laryngopharynx swelling and pain, convulsion and convulsion, venomous snake bite, traumatic injury pain, blood stasis and swelling and pain, enteritis, tumor, etc. The paris polyphylla extract has the effects of resisting bacteria and inflammation, relieving allergy, activating blood and dissolving stasis, removing freckles, calming and improving blood circulation, has good skin care effect, can repair damaged skin, make the skin healthier, prevent skin aging, reduce skin redness caused by ultraviolet ray stimulation, repair damaged skin barrier, help skin to maintain stability and establish healthy skin ecology. Suitable paris polyphylla extracts may be derived from the biological technology company of new world of Shaanxi.
Preferably, the soothing anti-allergic composition contains 0.2-1.5 parts by mass of coptis chinensis extract. More preferably 0.3 to 1.5 parts, 0.4 to 1.5 parts, 0.5 to 1.5 parts, 0.6 to 1.4 parts, 0.7 to 1.3 parts. Coptis chinensis is a traditional Chinese medicine commonly used in China, can treat skin inflammation, eczema, wound healing and the like, and has strong antibacterial property; the Coptidis rhizoma extract has effects in promoting collagen production, activating skin, and combining with their oxidation resistance, and can be used in antiaging cosmetics; the Coptidis rhizoma extract has excellent allergy inhibiting effect, skin whitening effect, and good moisturizing effect. Suitable coptis extracts may be derived from zheng state Kang Ji yuan biotechnology limited.
Preferably, the soothing anti-allergic composition contains 0.1-1.2 parts by mass of licorice extract. More preferably 0.2 to 1.2 parts, 0.3 to 1.2 parts, 0.4 to 1.1 parts, 0.5 to 1.0 parts. The Glycyrrhrizae radix extract can effectively promote moisture retention of skin care product, has antihistaminic and vasodilating effects, can relieve inflammatory reaction of subacute and chronic dermatoses, and can be used for treating chronic dermatoses such as contact dermatitis, atopic dermatitis and psoriasis. In addition, it has a lightening effect on pigmented skin. The Glycyrrhrizae radix extract has effect in inhibiting skin allergy, anaphylaxis, etc. It is helpful for repairing wound due to acne, sunburn, etc. Glycyrrhrizae radix has inhibiting effect on bacterial infection, edema, inflammation, etc. caused by skin. And can effectively inhibit liquid exudation and proliferation caused by wound. Besides remarkable antibacterial effect, the licorice extract also has a certain effect on whitening and sun protection. Suitable licorice extracts may be derived from western security Feida biotechnology Co.
Preferably, the soothing anti-allergic composition contains 0.6-3.0 parts by mass of Gymnema sylvestre extract. More preferably 0.7 to 3.0 parts, 0.8 to 2.9 parts, 0.9 to 2.8 parts, 1.0 to 2.7 parts, 1.2 to 2.5 parts. Gymnema sylvestre, rhizoma Smilacis Bockii, fructus Toosendan, and Paeonia ostii. Contains triterpene saponin, its aglycone contains gymnemic acid aglycone and gymnemic acid aglycone, and also contains spoonPicric acid A1-A4, glucuronic acid and gymnemine; the leaf contains eicosane, triacontane and cowThe vegetable alcohol A contains Gymnema saponine I-V, gymnemic acid III, IV, V, VIII, IX and chitosan; and two pectic substances are separated from the Gymnema sylvestre water extract and are inhibitors of hyaluronidase. Neutral in nature and bitter in taste. Has the effects of detumescence, detoxification, heat clearing and blood cooling. For multiple abscess, deep abscess, mastitis, carbuncle, sore and toxic swelling. The extract has excellent soothing, antiallergic, antiinflammatory and antibacterial effects. Suitable Gymnema sylvestre extracts may be derived from Nanjin Proyi Biotechnology Inc.
Preferably, the soothing anti-allergic composition of the present invention comprises, in parts by mass, 0.5 to 2.0 parts of ginseng extract, 0.5 to 2.5 parts of potentilla discolor extract, 0.5 to 2.2 parts of rhizoma paridis extract, 0.2 to 1.5 parts of coptis extract, 0.1 to 1.2 parts of licorice extract and 0.6 to 3.0 parts of martial arts extract.
Preferably, the mass ratio of the coptis chinensis extract to the Gymnema sylvestre extract is (0.4-0.65): 1. more preferably (0.4 to 0.6): 1. (0.42-0.55): 1 or (0.45-0.55): 1.
preferably, the mass ratio of the ginseng extract to the discolor cinquefoil herb extract is (0.8-1.05): 1. more preferably (0.85-1.05): 1. (0.9-1.05): 1 or (0.9-1.0): 1.
preferably, the composition contains 0.6-1.8 parts of ginseng extract, 0.7-2.3 parts of discolor cinquefoil herb extract, 0.6-2.0 parts of rhizoma paridis extract, 0.5-1.1 parts of coptis extract, 0.3-1.0 parts of licorice extract and 0.8-2.7 parts of Gymnema sylvestre extract in parts by mass.
In another aspect, the present invention provides a method for preparing the composition, comprising the step of mixing the ginseng extract, the potentilla discolor extract, the paris polyphylla extract, the coptis chinensis extract, the licorice extract and the martial arts extract.
Preferably, the step of mixing comprises stirring at a speed of 50 to 5000 rpm for 0.1 to 5 hours at a temperature of 20 to 60 ℃. More preferably, the temperature is 20-50deg.C, 20-45deg.C, 22-40deg.C or 22-30deg.C. More preferably, the stirring speed is 100 to 4000 rpm, 100 to 3000 rpm, 100 to 2000 rpm or 150 to 1000 rpm. More preferably, the stirring time is 0.2 to 5 hours, 0.3 to 4 hours, 0.4 to 3 hours or 0.5 to 2 hours.
In another aspect, the present invention provides a soothing anti-allergic cosmetic comprising the composition.
Preferably, the cosmetic contains 0.5 to 10wt% of the composition.
Preferably, the cosmetic further comprises sodium bis (lauramide glutamine) lysine and an emulsifier Montanov TM 82。
Preferably, the sodium di (lauramide glutamine) lysine and the emulsifier Montanov TM 82 is used in an amount of 0.2-1.5wt% and 0.3-2.2wt% in the cosmetic.
Preferably, the sodium di (lauramide glutamine) lysine and the emulsifier Montanov TM 82 mass ratio is 1: (1.1-1.6).
Preferably, the cosmetic is a cream, lotion, ointment or emulsion.
In another aspect, the present invention provides a soothing anti-allergic cosmetic comprising: 0.5-10wt% of the composition, 0.2-1.5wt% of sodium bis (lauramide glutamine) lysine, 0.3-2.2wt% of an emulsifier Montanov TM 82. 5-20wt% of an emollient, 8-25wt% of a humectant, 1-8wt% of a skin conditioning agent, 0-1.0wt% of a chelating agent, 0-0.5wt% of a preservative and 30-70wt% of water.
Preferably, the composition is used in cosmetics in an amount of 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5wt% or a range between any two of the above values.
Preferably, the sodium di (lauramide glutamine) lysine is used in cosmetics in an amount of 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4wt% or a range between any two of the above values.
Preferably, the emulsifier Montanov TM 82 is used in cosmetics in an amount of 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1wt% or a range between any two of the above values.
Preferably, the sodium di (lauramide glutamine) lysine and the emulsifier Montanov are used for increasing the soothing and antiallergic effects of the cosmetic and promoting the absorption effects of the active ingredient TM 82 mass ratio is 1: (1.1-1.6). More preferably 1: (1.2-1.6), 1: (1.2-1.55), 1: (1.3-1.55) or 1: (1.35-1.55).
Preferably, the emollient is present in the cosmetic in an amount of 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19wt% or a range between any two of the foregoing. The emollient is at least one selected from polydimethylsiloxane, squalane, grapeseed oil, linseed oil, evening primrose oil, tea seed oil, shea butter, avocado oil, nut oil, and glyceryl caprylate/caprate.
Preferably, the humectant is used in cosmetics in an amount of 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24wt% or a range between any two of the above values. The humectant can be at least one selected from glycerol, ethylene glycol, propylene glycol, sorbitol, betaine, and sodium hyaluronate.
Preferably, the skin conditioning agent is used in cosmetics in an amount of 2, 3, 4, 5, 6, 7wt% or a range between any two of the above values. The skin conditioner can be at least one selected from allantoin, dipotassium glycyrrhizinate, bisabolol, ceramide, saccharide isomer, tocopheryl acetate, pentaerythritol tetra (bis-tert-butylhydroxyhydrocinnamate).
Preferably, the chelating agent is used in the cosmetic in an amount of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9wt% or a range between any two of the above values. The chelating agent can be at least one of sodium citrate, EDTA and its salt, sodium tartrate and potassium tartrate.
Preferably, the preservative is used in cosmetics in an amount of 0.01, 0.05, 0.1, 0.2, 0.3, 0.4wt% or a range between any two of the above values. The antiseptic can be at least one of methyl benzoate, ethyl benzoate, phenoxyethanol, sodium benzoate, and p-hydroxyacetophenone.
Preferably, the water is used in cosmetics in an amount of 35, 40, 45, 50, 52, 55, 58, 60, 62, 65, 68wt% or a range between any two of the above.
The beneficial effects are that:
the composition for relieving and resisting allergy provided by the invention contains 0.5-2.0 parts of ginseng extract, 0.5-2.5 parts of discolor cinquefoil herb extract, 0.5-2.2 parts of rhizoma paridis extract, 0.2-1.5 parts of coptis chinensis extract, 0.1-1.2 parts of licorice extract and 0.6-3.0 parts of Gymnema sylvestre extract, and has excellent effect of relieving and resisting allergy and smooth skin. The average value of the skin redness score of the cosmetic obtained by using the composition is as low as 0.94 point at 20 minutes, and the average value of the skin redness score at 50 minutes is as low as 0.73 point; the cosmetic obtained by using the composition can reduce skin roughness by 39.83% at week 7. The soothing anti-allergic composition can endow cosmetics with excellent soothing anti-allergic and smooth skin effects.
The coptis extract and the Gymnema sylvestre extract in the anti-allergy relieving composition can produce a mutual synergistic interaction effect when the anti-allergy relieving effect is given to the product, and the interaction of the coptis extract and the Gymnema sylvestre extract remarkably increases the anti-allergy relieving effect of the product. When the ratio of the amount of the coptis extract to the amount of the Gymnema sylvestre extract is (0.4-0.65): when the content is within the range of 1, the effect of relieving and resisting allergy of the product is more remarkable.
The ginseng extract and the discolor cinquefoil herb extract of the invention produce a synergistic effect when giving the product a smooth skin effect. When the ratio of the ginseng extract amount to the discolor cinquefoil herb extract amount is (0.8-1.05): within the range of 1, a more excellent skin smoothness-increasing effect can be imparted to the product.
The second invention (month)Cinnamamide glutamine) sodium lysine, montanov TM 82 together promote the effect of improving the soothing and antiallergic effects and smoothing the skin of the cosmetic.
The composition for relieving and resisting allergy is green, environment-friendly, safe and reliable, and has a wide application range; the cosmetic properties obtained by using the soothing anti-allergic composition are excellent.
Detailed Description
The effects of the present invention will be described below in connection with specific test groups. Those skilled in the art will appreciate that these specific test sets are illustrative of the invention and are not limiting thereof. The raw materials of the test group of the invention: the ginseng extract is from Hunan green and vines biotechnology Co.Ltd; the potentilla discolor extract is derived from Sichuan Runbao Biotechnology Co., ltd; the paris polyphylla extract is from Shaanxi Xintian biotechnology limited company; the coptis extract is from Kang Ji Yuan Biotechnology Co., ltd; the licorice extract is derived from Sichuan Feida biotechnology Co., ltd; the Gymnema sylvestre extract is from Nanjing Proyi biosciences, inc.; emulsifying agent MONTANOV TM 82 is from beijing pu Long Da, a science trade company, inc.
1. Composition of the soothing anti-allergic composition is calculated in parts by mass. The compositions are set forth in Table 1.
Table 1: composition of soothing anti-allergic composition
Wherein, the A value is the ratio of the amount of coptis chinensis extract to the amount of Gymnema sylvestre extract; the value B is the ratio of the amount of ginseng extract to the amount of discolor cinquefoil herb extract.
The preparation methods of the soothing and antiallergic composition are as follows: the extract is stirred at the temperature of 25 ℃ for 1.5 hours at the rotation speed of 500 revolutions per minute to obtain the soothing and antiallergic composition.
The above soothing anti-sensitization composition was applied to the following soothing anti-sensitization cosmetics. The specific composition is shown in Table 2, the amounts of the ingredients are calculated in wt%, and the raw material composition 1 of the cosmetics 1-6 is the soothing and antiallergic composition 1 described in the above Table 1.
Table 2: composition of cosmetics for relieving and resisting allergy
The preparation method of the cosmetics 1-6 comprises the following steps: the raw materials and water are stirred for 1 hour at the temperature of 35 ℃ at the stirring speed of 300 revolutions per minute, and are uniformly mixed.
Wherein, cosmetic 1A: the only difference from cosmetic 1 is that composition 2 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1B: the only difference from cosmetic 1 is that composition 3 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1C: the only difference from cosmetic 1 is that composition 4 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1D: the only difference from cosmetic 1 is that composition 5 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1E: the only difference from cosmetic 1 is that composition 6 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1F: the only difference from cosmetic 1 is that composition 7 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1G: the only difference from cosmetic 1 is that composition 8 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1H: the only difference from cosmetic 1 is that composition 9 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Cosmetic 1I: the only difference from cosmetic 1 is that composition 10 was used instead of composition 1 as a raw material to prepare a cosmetic; the other components are the same as those of cosmetic 1.
Performance test for cosmetics:
1. test for soothing anti-allergy test
Several subjects aged 35-45 years were randomized into groups of 10 subjects each, with 5 subjects for men and women. The left hand forearm of the subject was divided into 2 small square areas of 3cm x 3cm (denoted as area 1 and area 2, respectively), 20 μl of histamine solution (allergen, concentration of 2wt%, solvent water) was applied to the patch, the patch was applied for 30min in each area, and then the patch was torn off;
area 1 was used as a sensitization control group and a blank group product (water) was applied; area 2 was smeared with the experimental group products (cosmetics 1-6, cosmetics 1A-1I); the coating amount is 0.2+/-0.02 g, and the sensitive phenomenon of each region is observed by photographing after 20min and 50min of coating respectively.
The skin red and swollen states of each group of subjects were scored, averaged and counted according to the skin reaction evaluation criteria described in table 3, and the test results are shown in table 4:
table 3: skin reaction evaluation criteria
Table 4: status scoring results of skin redness and swelling in subjects
As shown in the test results of Table 4, the soothing and antiallergic composition of the present invention comprising 0.5-2.0 parts of ginseng extract, 0.5-2.5 parts of Potentilla discolor extract, 0.5-2.2 parts of Paris polyphylla extract, 0.2-1.5 parts of coptis extract, 0.1-1.2 parts of licorice extract and 0.6-3.0 parts of Gymnema sylvestre extract has excellent soothing and antiallergic effects, and the average value of skin redness score of the cosmetic obtained by using the composition at 20 minutes is as low as 0.94 minutes, and the average value of skin redness score at 50 minutes is as low as 0.73 minutes.
The cosmetics 3 and 4 of the present invention are respectively prepared by using sodium bis (lauramide glutamine) lysine and MONTANOV TM 82, but the resulting cosmetic products have a soothing anti-sensitization effect lower than that of cosmetic 1 using both of the above-mentioned emulsifiers simultaneously; sodium di (lauramide glutamine) lysine, montanov of the present invention TM 82 produces a compound effect when preparing the soothing and antiallergic cosmetic composition, and can synergistically increase the soothing and antiallergic effects of the cosmetic. From the results of the tests of cosmetics 5 to 6 and cosmetic 1 in Table 4, it is found that when the mass ratio of sodium di (lauramide glutamine) lysine to emulsifier MONTANOV (TM) 82 is 1: in the range of (1.1-1.6), the cosmetic product has a better soothing anti-allergic effect.
As can be seen from the comparison of the cosmetics 1F-1I and the cosmetics 1, the coptis chinensis extract and the Gymnema sylvestre extract in the soothing anti-allergic composition can produce a mutual synergistic interaction when the soothing anti-allergic effect of the product is given, and the interaction of the coptis chinensis extract and the Gymnema sylvestre extract remarkably increases the soothing anti-allergic effect of the product. When the ratio of the amount of the coptis extract to the amount of the Gymnema sylvestre extract (namely, the A value) is between (0.4 and 0.65): when the content is within the range of 1, the product has more remarkable effect of improving skin relaxation and anti-sensitization.
2. Smooth skin test
Several subjects 30-40 years old were selected, randomly grouped, and 10 subjects for men and women were each 5, and the above-mentioned cosmetics (cosmetics 1-6, cosmetics 1A-1I) were used, respectively. The subjects applied the test group product 1.5.+ -. 0.1g each twice a day on the inner side of the arm about 10cm from the base of the palm, and after week 0 and week 7 of the test group product, the subjects washed the applied sites each week at the same time, and the average skin roughness of the applied area was measured using a multifunctional dermoscope image analysis system. Average change rate (%) = (average roughness of skin at week 0-average roughness at week 7)/average roughness of skin at week 0. The smooth skin test results are shown in table 5.
Table 5: smooth skin test
As can be seen from the test results of Table 5, the soothing and anti-allergic composition of the present invention comprising ginseng extract in an amount of 0.5-2.0 parts, potentilla discolor extract in an amount of 0.5-2.5 parts, paris polyphylla extract in an amount of 0.5-2.2 parts, coptis extract in an amount of 0.2-1.5 parts, licorice extract in an amount of 0.1-1.2 parts and Gymnema sylvestre extract in an amount of 0.6-3.0 parts has excellent skin smoothing effect, and the cosmetic obtained using the composition can reduce skin roughness by 39.83% at 7 th week.
The cosmetics 3 and 4 of the present invention use only sodium di (lauramide glutamine) lysine, montanov TM 82, but the skin roughness reducing effect of the resulting cosmetic product is lower than that of cosmetic 1 using both of the above-mentioned emulsifiers simultaneously; from these results, it was found that sodium di (lauramide glutamine) lysine and Montanov according to the present invention TM 82 produces a compound effect when preparing the soothing anti-allergic cosmetic composition, and can increase the skin smoothing effect of the cosmetic. From the results of the tests of cosmetics 5 to 6 and cosmetic 1 in Table 5, it is found that when the mass ratio of sodium di (lauramide glutamine) lysine to emulsifier MONTANOV (TM) 82 is 1: in the range of (1.1-1.6), the cosmetic product has a better skin smoothing effect.
As can be seen from the comparison of cosmetics 1B-1E with cosmetic 1, the ginseng extract and the potentilla discolor extract in the soothing and antiallergic composition can produce a mutual promotion effect when the product has a smooth skin effect, and the two can produce a synergistic effect to a certain extent, so that the smooth skin effect of the product is remarkably improved. When the ratio of the ginseng extract amount to the discolor cinquefoil herb extract amount (i.e., the B value) is in the range of (0.8-1.05): within 1, the product has more remarkable effect of improving skin smoothness.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
Claims (10)
1. A soothing anti-allergic composition characterized in that: the composition comprises, by mass, 0.5-2.0 parts of ginseng extract, 0.5-2.5 parts of potentilla discolor extract, 0.5-2.2 parts of rhizoma paridis extract, 0.2-1.5 parts of coptis extract, 0.1-1.2 parts of licorice extract and 0.6-3.0 parts of Gymnema sylvestre extract.
2. The composition of claim 1, wherein: the mass ratio of the coptis chinensis extract to the Gymnema sylvestre extract is (0.4-0.65): 1.
3. the composition of claim 1, wherein: the mass ratio of the ginseng extract to the discolor cinquefoil herb extract is (0.8-1.05): 1.
4. the composition of claim 1, wherein: the composition comprises, by mass, 0.6-1.8 parts of ginseng extract, 0.7-2.3 parts of potentilla discolor extract, 0.6-2.0 parts of rhizoma paridis extract, 0.5-1.1 parts of coptis extract, 0.3-1.0 parts of licorice extract and 0.8-2.7 parts of Gymnema sylvestre extract.
5. A method of preparing a composition according to any one of claims 1 to 4, wherein: comprises the steps of mixing the ginseng extract, the discolor cinquefoil herb extract, the paris polyphylla extract, the coptis chinensis extract, the licorice extract and the Gymnema sylvestre extract.
6. A soothing anti-sensitization cosmetic characterized by: a composition comprising the composition of any one of claims 1-4.
7. The cosmetic product of claim 6, wherein: the cosmetic comprises 0.5 to 10wt% of the composition according to any one of claims 1 to 4.
8. The cosmetic product of claim 6, wherein: the cosmetic also contains sodium di (lauramide glutamine) lysine and emulsifier Montanov TM 82。
9. The cosmetic product of claim 8, wherein: sodium di (lauramide glutamine) lysine and emulsifier Montanov TM 82 is used in an amount of 0.2-1.5wt% and 0.3-2.2wt% in the cosmetic.
10. The cosmetic product of claim 8, wherein: sodium di (lauramide glutamine) lysine and emulsifier Montanov TM 82 mass ratio is 1: (1.1-1.6).
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| JP2002316937A (en) * | 2001-04-19 | 2002-10-31 | Ichimaru Pharcos Co Ltd | Plant extract-containing anti-allergic agent |
| JP2003261417A (en) * | 2002-03-08 | 2003-09-16 | Noevir Co Ltd | Skin care preparation |
| CN105769741A (en) * | 2016-05-19 | 2016-07-20 | 覃政强 | Whitening mask lotion suitable for sensitive skins and preparation method thereof |
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| CN108309888A (en) * | 2018-04-18 | 2018-07-24 | 佛山市三水区嘉华化学研究院（普通合伙） | A kind of anti-inflammation detumescence Deacne pack |
| CN109908056A (en) * | 2019-03-29 | 2019-06-21 | 天津美臣生物科技有限公司 | It is a kind of with antiallergic, the skin care compositions releived, repair sensitive skin and preparation method thereof |
| CN113520941A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | Moisturizing and repairing composition and preparation method thereof |
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| JP2002316937A (en) * | 2001-04-19 | 2002-10-31 | Ichimaru Pharcos Co Ltd | Plant extract-containing anti-allergic agent |
| JP2003261417A (en) * | 2002-03-08 | 2003-09-16 | Noevir Co Ltd | Skin care preparation |
| CN105769741A (en) * | 2016-05-19 | 2016-07-20 | 覃政强 | Whitening mask lotion suitable for sensitive skins and preparation method thereof |
| CN107714594A (en) * | 2017-12-11 | 2018-02-23 | 方政 | A kind of sensitive skin is releived liquid and its preparation technology |
| CN108309888A (en) * | 2018-04-18 | 2018-07-24 | 佛山市三水区嘉华化学研究院（普通合伙） | A kind of anti-inflammation detumescence Deacne pack |
| CN109908056A (en) * | 2019-03-29 | 2019-06-21 | 天津美臣生物科技有限公司 | It is a kind of with antiallergic, the skin care compositions releived, repair sensitive skin and preparation method thereof |
| CN113520941A (en) * | 2021-07-15 | 2021-10-22 | 广东雷诺化妆品研究院有限公司 | Moisturizing and repairing composition and preparation method thereof |
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