CN113474339B - 作为malt1抑制剂的化合物的结晶形式 - Google Patents

作为malt1抑制剂的化合物的结晶形式 Download PDF

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Publication number
CN113474339B
CN113474339B CN202080015968.5A CN202080015968A CN113474339B CN 113474339 B CN113474339 B CN 113474339B CN 202080015968 A CN202080015968 A CN 202080015968A CN 113474339 B CN113474339 B CN 113474339B
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cancer
crystalline form
lymphoma
disease
compound
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Chinese (zh)
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CN113474339A (zh
Inventor
C·雷斯
K·L·金佩
R·M·格尔特曼
魏昊娟
周鹏
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202080015968.5A 2019-02-22 2020-02-20 作为malt1抑制剂的化合物的结晶形式 Active CN113474339B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2019/075834 2019-02-22
CN2019075834 2019-02-22
PCT/EP2020/054485 WO2020169736A1 (en) 2019-02-22 2020-02-20 Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-n-(2-(trifluoromethyl)pyridin-4-yl)-1h-pyrazole-4-carboxamide monohydrate

Publications (2)

Publication Number Publication Date
CN113474339A CN113474339A (zh) 2021-10-01
CN113474339B true CN113474339B (zh) 2025-02-25

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US (1) US12269813B2 (https=)
EP (1) EP3927696B1 (https=)
JP (1) JP2022523368A (https=)
KR (1) KR20210131371A (https=)
CN (1) CN113474339B (https=)
AU (1) AU2020226723B2 (https=)
BR (1) BR112021016400A2 (https=)
CA (1) CA3129623A1 (https=)
EA (1) EA202192320A1 (https=)
EC (1) ECSP21067828A (https=)
ES (1) ES2966132T3 (https=)
IL (1) IL285675A (https=)
JO (1) JOP20210227A1 (https=)
MA (1) MA55019A (https=)
MX (1) MX2021010133A (https=)
PE (1) PE20212067A1 (https=)
PH (1) PH12021552018A1 (https=)
SG (1) SG11202108909SA (https=)
TW (1) TW202045495A (https=)
UY (1) UY38592A (https=)
WO (1) WO2020169736A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
ES2949871T3 (es) 2019-04-11 2023-10-03 Janssen Pharmaceutica Nv Anillos de piridina que contienen derivados como inhibidores de MALT1
JP2023539729A (ja) 2020-08-21 2023-09-19 ヤンセン ファーマシューティカ エヌ．ベー． Ｍａｌｔ１阻害剤の非晶質形態及びその製剤
JP2024508890A (ja) 2021-03-03 2024-02-28 ヤンセン ファーマシューティカ エヌ．ベー． 治療有効用量のｍａｌｔ１阻害剤ｊｎｊ－６７８５６６３３（１－（１－オキソ－１，２－ジヒドロイソキノリン－５－イル）－５－（トリフルオロメチル）－ｎ－（２－（トリフルオロメチル）ピリジン－４－イル）－１ｈ－ピラゾール－４－カルボキサミド）を使用して状態を治療する方法
EP4301365A1 (en) 2021-03-03 2024-01-10 Janssen Pharmaceutica NV Combination therapy using a malt1 inhibitor and a btk inhibitor
KR20240046170A (ko) 2021-08-09 2024-04-08 얀센 파마슈티카 엔브이 B-세포 악성종양의 치료에 사용하기 위한 조성물
AU2024357109A1 (en) 2023-10-06 2026-03-12 Ionctura Sa Combination of roginolisib with a malt1-gls inhibitor

Citations (1)

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WO2018119036A1 (en) * 2016-12-21 2018-06-28 Janssen Biotech, Inc. Pyrazole derivatives as malt1 inhibitors

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CA2522994C (en) 2003-04-30 2012-09-25 Agensys, Inc. Nucleic acids and corresponding proteins entitled 109p1d4 useful in treatment and detection of cancer
ES2336625T3 (es) * 2006-03-22 2010-04-14 Vertex Pharmaceuticals Incorporated Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos.
WO2008092292A1 (en) 2007-01-17 2008-08-07 The Hong Kong University Of Science And Technology Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2
WO2011036885A1 (ja) * 2009-09-25 2011-03-31 武田薬品工業株式会社 複素環化合物
US20120071497A1 (en) 2010-06-03 2012-03-22 Pharmacyclics, Inc. Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
JP5984801B2 (ja) 2010-06-22 2016-09-06 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ４−ヒドロキシピリジン類の製造方法
KR20150020228A (ko) * 2012-05-31 2015-02-25 에프. 호프만-라 로슈 아게 아미노퀴나졸린 및 피리도피리미딘 유도체
ES2738695T3 (es) 2014-05-28 2020-01-24 Novartis Ag Nuevos Derivados de Pirazolo Pirimidina y su uso como inhibidores de MALT1
CA2956550A1 (en) 2014-08-08 2016-02-11 Pharmacyclics Llc Bruton's tyrosine kinase inhibitor combinations and uses thereof
WO2016209688A1 (en) * 2015-06-24 2016-12-29 University Of Florida Research Foundation, Incorporated Compositions for the treatment of cancer and uses thereof
WO2017081641A1 (en) 2015-11-13 2017-05-18 Novartis Ag Novel pyrazolo pyrimidine derivatives
US10882841B2 (en) 2016-03-01 2021-01-05 University Of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
US20200009135A1 (en) 2017-02-01 2020-01-09 Medivir Ab Therapeutic applications of malt1 inhibitors
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JP2023539729A (ja) * 2020-08-21 2023-09-19 ヤンセン ファーマシューティカ エヌ．ベー． Ｍａｌｔ１阻害剤の非晶質形態及びその製剤

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WO2018119036A1 (en) * 2016-12-21 2018-06-28 Janssen Biotech, Inc. Pyrazole derivatives as malt1 inhibitors

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US12269813B2 (en) 2025-04-08
MX2021010133A (es) 2021-09-23
CA3129623A1 (en) 2020-08-27
AU2020226723A1 (en) 2021-08-19
ECSP21067828A (es) 2021-11-18
SG11202108909SA (en) 2021-09-29
US20220127249A1 (en) 2022-04-28
PH12021552018A1 (en) 2022-09-19
AU2020226723B2 (en) 2025-01-23
JP2022523368A (ja) 2022-04-22
BR112021016400A2 (pt) 2021-10-13
EP3927696A1 (en) 2021-12-29
PE20212067A1 (es) 2021-10-26
EP3927696B1 (en) 2023-10-18
UY38592A (es) 2020-08-31
ES2966132T3 (es) 2024-04-18
IL285675A (en) 2021-10-31
MA55019A (fr) 2021-12-29
EP3927696C0 (en) 2023-10-18
CN113474339A (zh) 2021-10-01
JOP20210227A1 (ar) 2021-08-18
EA202192320A1 (ru) 2021-11-16
WO2020169736A1 (en) 2020-08-27
KR20210131371A (ko) 2021-11-02
TW202045495A (zh) 2020-12-16

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