EA202192320A1 - Кристаллическая форма моногидрата 1-(1-оксо-1,2-дигидроизохинолин-5-ил)-5-(трифторметил)-n-[2-(трифторметил)пиридин-4-ил]-1h-пиразол-4-карбоксамида - Google Patents
Кристаллическая форма моногидрата 1-(1-оксо-1,2-дигидроизохинолин-5-ил)-5-(трифторметил)-n-[2-(трифторметил)пиридин-4-ил]-1h-пиразол-4-карбоксамидаInfo
- Publication number
- EA202192320A1 EA202192320A1 EA202192320A EA202192320A EA202192320A1 EA 202192320 A1 EA202192320 A1 EA 202192320A1 EA 202192320 A EA202192320 A EA 202192320A EA 202192320 A EA202192320 A EA 202192320A EA 202192320 A1 EA202192320 A1 EA 202192320A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- trifluoromethyl
- crystalline form
- pyridin
- oxo
- dihydroisochinolin
- Prior art date
Links
- HVWKJSJNIWVJGF-UHFFFAOYSA-N 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide hydrate Chemical compound C1=CC2=C(C=CNC2=O)C(=C1)N3C(=C(C=N3)C(=O)NC4=CC(=NC=C4)C(F)(F)F)C(F)(F)F.O HVWKJSJNIWVJGF-UHFFFAOYSA-N 0.000 title 1
- APWRZPQBPCAXFP-UHFFFAOYSA-N 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide Chemical compound O=C1NC=CC2=C(C=CC=C12)N1N=CC(=C1C(F)(F)F)C(=O)NC1=CC(=NC=C1)C(F)(F)F APWRZPQBPCAXFP-UHFFFAOYSA-N 0.000 abstract 1
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 102000057613 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Human genes 0.000 abstract 1
- 108700026676 Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019075834 | 2019-02-22 | ||
| PCT/EP2020/054485 WO2020169736A1 (en) | 2019-02-22 | 2020-02-20 | Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-n-(2-(trifluoromethyl)pyridin-4-yl)-1h-pyrazole-4-carboxamide monohydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202192320A1 true EA202192320A1 (ru) | 2021-11-16 |
Family
ID=69723907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202192320A EA202192320A1 (ru) | 2019-02-22 | 2020-02-20 | Кристаллическая форма моногидрата 1-(1-оксо-1,2-дигидроизохинолин-5-ил)-5-(трифторметил)-n-[2-(трифторметил)пиридин-4-ил]-1h-пиразол-4-карбоксамида |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12269813B2 (https=) |
| EP (1) | EP3927696B1 (https=) |
| JP (1) | JP2022523368A (https=) |
| KR (1) | KR20210131371A (https=) |
| CN (1) | CN113474339B (https=) |
| AU (1) | AU2020226723B2 (https=) |
| BR (1) | BR112021016400A2 (https=) |
| CA (1) | CA3129623A1 (https=) |
| EA (1) | EA202192320A1 (https=) |
| EC (1) | ECSP21067828A (https=) |
| ES (1) | ES2966132T3 (https=) |
| IL (1) | IL285675A (https=) |
| JO (1) | JOP20210227A1 (https=) |
| MA (1) | MA55019A (https=) |
| MX (1) | MX2021010133A (https=) |
| PE (1) | PE20212067A1 (https=) |
| PH (1) | PH12021552018A1 (https=) |
| SG (1) | SG11202108909SA (https=) |
| TW (1) | TW202045495A (https=) |
| UY (1) | UY38592A (https=) |
| WO (1) | WO2020169736A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI795381B (zh) | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| ES2949871T3 (es) | 2019-04-11 | 2023-10-03 | Janssen Pharmaceutica Nv | Anillos de piridina que contienen derivados como inhibidores de MALT1 |
| JP2023539729A (ja) | 2020-08-21 | 2023-09-19 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤の非晶質形態及びその製剤 |
| JP2024508890A (ja) | 2021-03-03 | 2024-02-28 | ヤンセン ファーマシューティカ エヌ．ベー． | 治療有効用量のｍａｌｔ１阻害剤ｊｎｊ－６７８５６６３３（１－（１－オキソ－１，２－ジヒドロイソキノリン－５－イル）－５－（トリフルオロメチル）－ｎ－（２－（トリフルオロメチル）ピリジン－４－イル）－１ｈ－ピラゾール－４－カルボキサミド）を使用して状態を治療する方法 |
| EP4301365A1 (en) | 2021-03-03 | 2024-01-10 | Janssen Pharmaceutica NV | Combination therapy using a malt1 inhibitor and a btk inhibitor |
| KR20240046170A (ko) | 2021-08-09 | 2024-04-08 | 얀센 파마슈티카 엔브이 | B-세포 악성종양의 치료에 사용하기 위한 조성물 |
| AU2024357109A1 (en) | 2023-10-06 | 2026-03-12 | Ionctura Sa | Combination of roginolisib with a malt1-gls inhibitor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2522994C (en) | 2003-04-30 | 2012-09-25 | Agensys, Inc. | Nucleic acids and corresponding proteins entitled 109p1d4 useful in treatment and detection of cancer |
| ES2336625T3 (es) * | 2006-03-22 | 2010-04-14 | Vertex Pharmaceuticals Incorporated | Inhibidores de la proteina quinasa c-met para el tratamiento de trastornos proliferativos. |
| WO2008092292A1 (en) | 2007-01-17 | 2008-08-07 | The Hong Kong University Of Science And Technology | Isoquinolone compounds as subtype-selective agonists for melatonin receptors mt1 and mt2 |
| WO2011036885A1 (ja) * | 2009-09-25 | 2011-03-31 | 武田薬品工業株式会社 | 複素環化合物 |
| US20120071497A1 (en) | 2010-06-03 | 2012-03-22 | Pharmacyclics, Inc. | Methods of treating abc-dlbcl using inhibitors of bruton's tyrosine kinase |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| JP5984801B2 (ja) | 2010-06-22 | 2016-09-06 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | ４−ヒドロキシピリジン類の製造方法 |
| KR20150020228A (ko) * | 2012-05-31 | 2015-02-25 | 에프. 호프만-라 로슈 아게 | 아미노퀴나졸린 및 피리도피리미딘 유도체 |
| ES2738695T3 (es) | 2014-05-28 | 2020-01-24 | Novartis Ag | Nuevos Derivados de Pirazolo Pirimidina y su uso como inhibidores de MALT1 |
| CA2956550A1 (en) | 2014-08-08 | 2016-02-11 | Pharmacyclics Llc | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
| WO2016209688A1 (en) * | 2015-06-24 | 2016-12-29 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of cancer and uses thereof |
| WO2017081641A1 (en) | 2015-11-13 | 2017-05-18 | Novartis Ag | Novel pyrazolo pyrimidine derivatives |
| US10882841B2 (en) | 2016-03-01 | 2021-01-05 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| TWI795381B (zh) * | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| US20200009135A1 (en) | 2017-02-01 | 2020-01-09 | Medivir Ab | Therapeutic applications of malt1 inhibitors |
| MX2020006808A (es) | 2017-12-28 | 2020-12-11 | Massachusetts Gen Hospital | Ubicar al complejo de signalosoma cbm induce a las celulas t reguladoras inflamar al microambiente tumoral. |
| US20210001733A1 (en) | 2018-02-23 | 2021-01-07 | Industrieanlagen-Betriebsgesellschaft Mbh | Device for generating a magnetic field, in particular for an inductive charging system, and primary device of an inductive charging system for dynamically charging vehicles |
| WO2021138298A1 (en) | 2019-12-30 | 2021-07-08 | Rheos Medicines, Inc. | Malt1 modulators and uses thereof |
| JP2023539729A (ja) * | 2020-08-21 | 2023-09-19 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｍａｌｔ１阻害剤の非晶質形態及びその製剤 |
-
2020
- 2020-02-20 PH PH1/2021/552018A patent/PH12021552018A1/en unknown
- 2020-02-20 EA EA202192320A patent/EA202192320A1/ru unknown
- 2020-02-20 KR KR1020217029765A patent/KR20210131371A/ko not_active Withdrawn
- 2020-02-20 CA CA3129623A patent/CA3129623A1/en active Pending
- 2020-02-20 JP JP2021549407A patent/JP2022523368A/ja active Pending
- 2020-02-20 MX MX2021010133A patent/MX2021010133A/es unknown
- 2020-02-20 BR BR112021016400-6A patent/BR112021016400A2/pt not_active Application Discontinuation
- 2020-02-20 ES ES20707585T patent/ES2966132T3/es active Active
- 2020-02-20 SG SG11202108909SA patent/SG11202108909SA/en unknown
- 2020-02-20 US US17/431,447 patent/US12269813B2/en active Active
- 2020-02-20 WO PCT/EP2020/054485 patent/WO2020169736A1/en not_active Ceased
- 2020-02-20 AU AU2020226723A patent/AU2020226723B2/en not_active Expired - Fee Related
- 2020-02-20 MA MA055019A patent/MA55019A/fr unknown
- 2020-02-20 EP EP20707585.4A patent/EP3927696B1/en active Active
- 2020-02-20 PE PE2021001372A patent/PE20212067A1/es unknown
- 2020-02-20 CN CN202080015968.5A patent/CN113474339B/zh active Active
- 2020-02-21 TW TW109105620A patent/TW202045495A/zh unknown
- 2020-02-21 UY UY0001038592A patent/UY38592A/es unknown
-
2021
- 2021-08-17 IL IL285675A patent/IL285675A/en unknown
- 2021-08-18 JO JOP/2021/0227A patent/JOP20210227A1/ar unknown
- 2021-09-14 EC ECSENADI202167828A patent/ECSP21067828A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US12269813B2 (en) | 2025-04-08 |
| MX2021010133A (es) | 2021-09-23 |
| CA3129623A1 (en) | 2020-08-27 |
| AU2020226723A1 (en) | 2021-08-19 |
| ECSP21067828A (es) | 2021-11-18 |
| SG11202108909SA (en) | 2021-09-29 |
| US20220127249A1 (en) | 2022-04-28 |
| PH12021552018A1 (en) | 2022-09-19 |
| CN113474339B (zh) | 2025-02-25 |
| AU2020226723B2 (en) | 2025-01-23 |
| JP2022523368A (ja) | 2022-04-22 |
| BR112021016400A2 (pt) | 2021-10-13 |
| EP3927696A1 (en) | 2021-12-29 |
| PE20212067A1 (es) | 2021-10-26 |
| EP3927696B1 (en) | 2023-10-18 |
| UY38592A (es) | 2020-08-31 |
| ES2966132T3 (es) | 2024-04-18 |
| IL285675A (en) | 2021-10-31 |
| MA55019A (fr) | 2021-12-29 |
| EP3927696C0 (en) | 2023-10-18 |
| CN113474339A (zh) | 2021-10-01 |
| JOP20210227A1 (ar) | 2021-08-18 |
| WO2020169736A1 (en) | 2020-08-27 |
| KR20210131371A (ko) | 2021-11-02 |
| TW202045495A (zh) | 2020-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA202192320A1 (ru) | Кристаллическая форма моногидрата 1-(1-оксо-1,2-дигидроизохинолин-5-ил)-5-(трифторметил)-n-[2-(трифторметил)пиридин-4-ил]-1h-пиразол-4-карбоксамида | |
| PH12020551304A1 (en) | Novel crystalline forms | |
| SA522432955B1 (ar) | Kras g12c مثبطات | |
| PE20210642A1 (es) | Inhibidores de pd-1/pd-l1 | |
| EA201890594A1 (ru) | Арильные, гетероарильные и гетероциклические соединения для лечения заболеваний | |
| EA201991697A1 (ru) | Сульфоксиминовые ингибиторы гликозидазы | |
| EA201691242A1 (ru) | Фармацевтические композиции, содержащие azd9291 | |
| AR111469A1 (es) | Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma | |
| EA201892505A1 (ru) | Амидозамещенные производные пиридинилтриазола и их применение | |
| EA201692268A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| EA201791955A1 (ru) | ИНГИБИТОРЫ TGF-β | |
| EA201991884A2 (ru) | Ингибиторы g12c kras | |
| EA202090256A1 (ru) | 5-членные и бициклические гетероциклические амиды в качестве ингибиторов rock | |
| EA201692267A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| EA201990678A1 (ru) | Гетероарилкарбоксамидные соединения в качестве ингибиторов ripk2 | |
| EA201791226A1 (ru) | Композиции, содержащие 2-((1-(2-(4-фторфенил)-2-оксоэтил)пиперидин-4-ил)метил)изоиндолин-1-он для лечения шизофрении | |
| EA201692474A1 (ru) | Производные 1-(циклопент-2-ен-1-ил)-3-(2-гидрокси-3-(арилсульфонил)фенил)мочевины в качестве ингибиторов cxcr2 | |
| MD3265459T2 (ro) | Compuși amidici în calitate de agoniști ai receptorilor 5-HT4 | |
| MX2018014298A (es) | Nueva forma cristalina de n-[5-(3,5-difluoro-bencilo)-1h-indazol-3 -il]-4-(4-metilo-piperazina-1-il)-2-(tetrahidro-pirano-4-ilamino) -benzamida. | |
| JOP20200100A1 (ar) | مشتقات بيرازولو-بيرولو-بيريميدين-ديون جديدة كمثبِّطات لـ p2x3 | |
| MX386586B (es) | Cristal de base libre de derivados benzofurano y método de preparación. | |
| EA202090193A1 (ru) | Кристаллическая форма n-[1-(5-цианопиридин-2-илметил)-1h-пиразол-3-ил]-2-[4-(1-трифторметилциклопропил)фенил]ацетамида | |
| CY1124056T1 (el) | Κρυσταλλικες μορφες της μηλεϊνικης 1-((2r, 4r)-2-(1η-βενζο[d] iμιδαζολ-2-υλο)-1-μεθυλοπιπεριδιν-4-υλο)-3-(4-κυανοφαινυλ) ουριας | |
| MD20190080A2 (ro) | Forme cristaline de (s)-afoxolaner | |
| EA201991428A1 (ru) | Фармацевтическая комбинация, содержащая блокатор кальциевых каналов т-типа |