PE20212067A1 - Forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifluorometil)-n-(2- (trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida monohidratada - Google Patents

Forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifluorometil)-n-(2- (trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida monohidratada

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Publication number
PE20212067A1
PE20212067A1 PE2021001372A PE2021001372A PE20212067A1 PE 20212067 A1 PE20212067 A1 PE 20212067A1 PE 2021001372 A PE2021001372 A PE 2021001372A PE 2021001372 A PE2021001372 A PE 2021001372A PE 20212067 A1 PE20212067 A1 PE 20212067A1
Authority
PE
Peru
Prior art keywords
trifluoromethyl
crystalline form
dihydroisoquinolin
carboxamide
pyridin
Prior art date
Application number
PE2021001372A
Other languages
English (en)
Inventor
Carina Leys
Kristof Leonard Kimpe
Robert Michael Geertman
Haojuan Wei
Peng Zhou
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20212067A1 publication Critical patent/PE20212067A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Referido a una forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5- (trifluorometil)-N-[2-(trifluorometil)piridin-4-il]-1H-pirazol-4-carboxamida (Compuesto A) monohidratada, donde la forma cristalina es la Forma III, que produce un patron de difraccion de rayos X de polvo que comprende picos a 16.4, 23.7 y 25.7 grados dos theta ± 0.2 grados dos theta. Tambien se refiere a composiciones farmaceuticas; el proceso de preparacion de la forma cristalina, que comprende el paso de recristalizar el compuesto A; y a su uso en el tratamiento del cancer y enfermedades, sindromes, trastornos o afecciones autoinmunologicos asociados con inhibidores de MALT1.
PE2021001372A 2019-02-22 2020-02-20 Forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifluorometil)-n-(2- (trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida monohidratada PE20212067A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2019075834 2019-02-22
PCT/EP2020/054485 WO2020169736A1 (en) 2019-02-22 2020-02-20 Crystalline form of 1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-n-(2-(trifluoromethyl)pyridin-4-yl)-1h-pyrazole-4-carboxamide monohydrate

Publications (1)

Publication Number Publication Date
PE20212067A1 true PE20212067A1 (es) 2021-10-26

Family

ID=69723907

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2021001372A PE20212067A1 (es) 2019-02-22 2020-02-20 Forma cristalina de 1-(1-oxo-1,2-dihidroisoquinolin-5-il)-5-(trifluorometil)-n-(2- (trifluorometil)piridin-4-il)-1h-pirazol-4-carboxamida monohidratada

Country Status (20)

Country Link
US (1) US20220127249A1 (es)
EP (1) EP3927696B1 (es)
JP (1) JP2022523368A (es)
KR (1) KR20210131371A (es)
CN (1) CN113474339A (es)
AU (1) AU2020226723A1 (es)
BR (1) BR112021016400A2 (es)
CA (1) CA3129623A1 (es)
EA (1) EA202192320A1 (es)
EC (1) ECSP21067828A (es)
ES (1) ES2966132T3 (es)
IL (1) IL285675A (es)
JO (1) JOP20210227A1 (es)
MA (1) MA55019A (es)
MX (1) MX2021010133A (es)
PE (1) PE20212067A1 (es)
SG (1) SG11202108909SA (es)
TW (1) TW202045495A (es)
UY (1) UY38592A (es)
WO (1) WO2020169736A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
CA3187118A1 (en) 2020-08-21 2022-02-24 Kristof Leonard KIMPE Amorphous form of a malt1 inhibitor and formulations thereof
EP4301364A1 (en) 2021-03-03 2024-01-10 Janssen Pharmaceutica NV Method of treating a condition using a therapeutically effective dose of the malt1 inhibitor jnj -67856633 (1 -(1 -oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-n-(2-(trifluoromethyl)pyridin-4-yl)-1 h-py razole-4-carboxamide)
MX2023010314A (es) 2021-03-03 2023-11-24 Janssen Pharmaceutica Nv Terapia de combinación usando un inhibidor de malt1 y un inhibidor de btk.
JP2024530204A (ja) * 2021-08-09 2024-08-16 ヤンセン ファーマシューティカ エヌ．ベー． Ｂ細胞悪性腫瘍の治療に使用するための組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008141761A (ru) * 2006-03-22 2010-04-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) ИНГИБИТОРЫ с-МЕТ ПРОТЕИНКИНАЗЫ
WO2011036885A1 (ja) * 2009-09-25 2011-03-31 武田薬品工業株式会社 複素環化合物
KR20150020228A (ko) * 2012-05-31 2015-02-25 에프. 호프만-라 로슈 아게 아미노퀴나졸린 및 피리도피리미딘 유도체
WO2016209688A1 (en) * 2015-06-24 2016-12-29 University Of Florida Research Foundation, Incorporated Compositions for the treatment of cancer and uses thereof
TWI795381B (zh) 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
CA3187118A1 (en) * 2020-08-21 2022-02-24 Kristof Leonard KIMPE Amorphous form of a malt1 inhibitor and formulations thereof

Also Published As

Publication number Publication date
SG11202108909SA (en) 2021-09-29
EP3927696C0 (en) 2023-10-18
UY38592A (es) 2020-08-31
US20220127249A1 (en) 2022-04-28
CN113474339A (zh) 2021-10-01
EA202192320A1 (ru) 2021-11-16
MX2021010133A (es) 2021-09-23
CA3129623A1 (en) 2020-08-27
IL285675A (en) 2021-10-31
BR112021016400A2 (pt) 2021-10-13
MA55019A (fr) 2021-12-29
TW202045495A (zh) 2020-12-16
KR20210131371A (ko) 2021-11-02
EP3927696A1 (en) 2021-12-29
JP2022523368A (ja) 2022-04-22
EP3927696B1 (en) 2023-10-18
ECSP21067828A (es) 2021-11-18
WO2020169736A1 (en) 2020-08-27
AU2020226723A1 (en) 2021-08-19
JOP20210227A1 (ar) 2023-01-30
ES2966132T3 (es) 2024-04-18

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