CN113456522A - Hand cream with recombinant human collagen as nutrient component and preparation method thereof - Google Patents
Hand cream with recombinant human collagen as nutrient component and preparation method thereof Download PDFInfo
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- CN113456522A CN113456522A CN202110546359.9A CN202110546359A CN113456522A CN 113456522 A CN113456522 A CN 113456522A CN 202110546359 A CN202110546359 A CN 202110546359A CN 113456522 A CN113456522 A CN 113456522A
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- recombinant human
- human collagen
- hand cream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
A hand cream with recombinant human collagen as a nutrient component and a preparation method thereof belong to the technical field of skin care products, can solve the problem that the human body cannot well absorb the nutrient component in the current hand cream, and comprise the following components in percentage by mass: 4-6% of glycerin, 4-6% of propylene glycol, 0.5-1% of xanthan gum, 2-4% of sodium lauryl sulfate, 3-5% of emulsifier, 0.1-0.5% of antibacterial agent, 10-30% of moistening agent, 1-2% of type III recombinant human collagen, 1-2% of sodium hyaluronate and the balance of water. The invention adopts recombinant human collagen, can induce epithelial cells to proliferate and differentiate, and has good moisturizing and moistening effects on hand skin.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to hand cream taking recombinant human collagen as a nutritional component and a preparation method thereof.
Background
Various essential oils exist in the current hand cream, and have the effects of moisturizing, sterilizing and disinfecting the skin. Fullerene can also be added as an antioxidant component to prevent and treat hand cream deterioration. However, most of the nutritional ingredients of the current hand cream are animal-derived collagen or oligopeptide, most of the ingredients are animal-derived ingredients, the ingredients are extracted from animals, certain hidden dangers exist in the biological safety, and the absorption effect of the human body on the hand cream is not good.
Disclosure of Invention
The invention provides a hand cream taking recombinant human collagen as a nutrient component and a preparation method thereof, aiming at the problem that the human body does not well absorb the nutrient components in the current hand cream. According to the invention, the human collagen is added into the hand cream, so that the hand cream can promote the hand skin of a human body to absorb the nutrient components in the hand cream, and the nourishing and moisturizing functions of the hand cream are better.
The invention adopts the following technical scheme:
a hand cream with recombinant human collagen as a nutritional component comprises the following components in percentage by mass: 4-6% of glycerin, 4-6% of propylene glycol, 0.5-1% of xanthan gum, 2-4% of sodium lauryl sulfate, 3-5% of emulsifier, 0.1-0.5% of antibacterial agent, 10-30% of moistening agent, 1-2% of type III recombinant human collagen, 1-2% of sodium hyaluronate and the balance of water.
Further, the emulsifier includes any one of beta-cyclodextrin, soluble soybean polysaccharide and soybean lecithin.
Further, the antibacterial agent comprises any one of compound antibacterial agents of Gemamo BP, compound polyol and phenoxyethanol.
Further, the moistening agent comprises any one of trehalose, luba oil and isooctyl palmitate.
A preparation method of hand cream with recombinant human collagen as nutrient component comprises the following steps:
step one, adding deionized water, glycerol, propylene glycol and xanthan gum into an emulsifying pot, homogenizing for 2-5min at the rotating speed of 1500-;
secondly, adding the emulsifier, the humectant and sodium lauryl sulfate into an oil phase pot, and heating to 80-100 ℃ until the solid in the oil phase pot is fully dissolved to obtain an oil phase mixture;
thirdly, adding the oil phase mixture A into the mixture in the emulsifying pot, homogenizing for 2-5min at the rotating speed of 1500-;
fourthly, cooling to 40-50 ℃, adding the antibacterial agent, stirring and uniformly dispersing;
fifthly, continuously cooling to 30-35 ℃, adding the type III recombinant human collagen and the hyaluronic acid, and uniformly stirring and dispersing to obtain a mixture B;
sixthly, putting the mixture B into an environment with the temperature of 4-6 ℃ for refrigeration for 20min, and filling.
The invention has the following beneficial effects:
the recombinant human collagen is produced by modifying, processing and fermenting escherichia coli by a biological fermentation method, and the human collagen is used as an excellent biological material, can induce epithelial cell proliferation and differentiation and has good moisturizing and moistening effects on hand skin.
The recombinant human collagen and the human collagen belong to homologous substances, and compared with animal collagen, the recombinant human collagen and the human collagen have better biocompatibility and biological safety and higher absorption efficiency by human bodies.
According to the invention, the human collagen is added into the hand cream, so that the hand cream can promote the hand skin of a human body to absorb the nutrient components in the hand cream, and the nourishing and moisturizing functions of the hand cream are better.
Detailed Description
Example 1
Sterilizing the experimental apparatus
Weighing 6g of glycerol, 6g of propylene glycol, 1g of xanthan gum, 4g of sodium lauryl sulfate, 5g of emulsifier, 0.5g of antibacterial agent, 30g of moistening agent, 2g of recombinant human collagen, 2g of sodium hyaluronate and 43.5g of deionized water.
Adding deionized water, glycerol, propylene glycol and xanthan gum into an emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, and heating to 80-90 ℃;
adding an emulsifier, a humectant and sodium lauryl sulfate into an oil phase pot, and adding the mixture to 80-100 ℃ until the solids are fully dissolved to obtain an oil phase mixture;
adding the oil phase mixture into the emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, continuing stirring, keeping the temperature at 80-90 ℃ for 10-20min, and beginning to cool;
cooling to 40-50 ℃, adding an antibacterial agent, stirring and uniformly dispersing;
and continuously cooling to 30-35 ℃, adding the type III recombinant human collagen and hyaluronic acid, stirring and uniformly dispersing.
And then placing the mixture into an environment with the temperature of 4-6 ℃ for refrigeration for 20 minutes, and filling.
Example 2
Weighing 4g of glycerol, 4g of propylene glycol, 0.5g of xanthan gum, 2g of sodium lauryl sulfate, 3g of emulsifier, 0.1g of antibacterial agent, 10g of moistening agent, 1g of recombinant human collagen, 1g of sodium hyaluronate and 74.4g of deionized water.
Adding deionized water, glycerol, propylene glycol and xanthan gum into an emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, and heating to 80-90 ℃;
adding an emulsifier, a humectant and sodium lauryl sulfate into an oil phase pot, and adding the mixture to 80-100 ℃ until the solids are fully dissolved to obtain an oil phase mixture;
adding the oil phase mixture into the emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, continuing stirring, keeping the temperature at 80-90 ℃ for 10-20min, and beginning to cool;
cooling to 40-50 ℃, adding an antibacterial agent, stirring and uniformly dispersing;
and continuously cooling to 30-35 ℃, adding the type III recombinant human collagen and hyaluronic acid, stirring and uniformly dispersing.
And then placing the mixture into an environment with the temperature of 4-6 ℃ for refrigeration for 20 minutes, and filling.
Example 3
Sterilizing the experimental apparatus
Weighing 5g of glycerol, 5g of propylene glycol, 0.8g of xanthan gum, 3g of sodium lauryl sulfate, 4g of emulsifier, 0.3g of antibacterial agent, 20g of moistening agent, 1.5g of recombinant human collagen, 1.5g of sodium hyaluronate and 58.9g of deionized water
Adding deionized water, glycerol, propylene glycol and xanthan gum into an emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, and heating to 80-90 ℃;
adding an emulsifier, a humectant and sodium lauryl sulfate into an oil phase pot, and adding the mixture to 80-100 ℃ until the solids are fully dissolved to obtain an oil phase mixture;
adding the oil phase mixture into the emulsifying pot, homogenizing for 2-5min at 1500-2500r/min, continuing stirring, keeping the temperature at 80-90 ℃ for 10-20min, and beginning to cool;
cooling to 40-50 ℃, adding an antibacterial agent, stirring and uniformly dispersing;
and continuously cooling to 30-35 ℃, adding the recombinant human collagen and the hyaluronic acid, stirring and uniformly dispersing.
And then placing the mixture into an environment with the temperature of 4-6 ℃ for refrigeration for 20 minutes, and filling.
Claims (5)
1. A hand cream using recombinant human collagen as a nutrient component is characterized in that: the composite material comprises the following components in percentage by mass: 4-6% of glycerin, 4-6% of propylene glycol, 0.5-1% of xanthan gum, 2-4% of sodium lauryl sulfate, 3-5% of emulsifier, 0.1-0.5% of antibacterial agent, 10-30% of moistening agent, 1-2% of type III recombinant human collagen, 1-2% of sodium hyaluronate and the balance of water.
2. The hand cream taking recombinant human collagen as a nutritional ingredient as claimed in claim 1, is characterized in that: the emulsifier comprises any one of beta-cyclodextrin, soluble soybean polysaccharide and soybean lecithin.
3. The hand cream taking recombinant human collagen as a nutritional ingredient as claimed in claim 1, is characterized in that: the antibacterial agent comprises any one of a compound antibacterial agent Gemame BP, a compound polyol and phenoxyethanol.
4. The hand cream taking recombinant human collagen as a nutritional ingredient as claimed in claim 1, is characterized in that: the moistening agent comprises one of trehalose, luba oil and isooctyl palmitate.
5. A method for preparing a hand cream containing recombinant human collagen as a nutritional ingredient according to any one of claims 1 to 4, wherein the method comprises the following steps: the method comprises the following steps:
step one, adding deionized water, glycerol, propylene glycol and xanthan gum into an emulsifying pot, homogenizing for 2-5min at the rotating speed of 1500-;
secondly, adding the emulsifier, the humectant and sodium lauryl sulfate into an oil phase pot, and heating to 80-100 ℃ until the solid in the oil phase pot is fully dissolved to obtain an oil phase mixture;
thirdly, adding the oil phase mixture A into the mixture in the emulsifying pot, homogenizing for 2-5min at the rotating speed of 1500-;
fourthly, cooling to 40-50 ℃, adding the antibacterial agent, stirring and uniformly dispersing;
fifthly, continuously cooling to 30-35 ℃, adding the type III recombinant human collagen and the hyaluronic acid, and uniformly stirring and dispersing to obtain a mixture B;
sixthly, putting the mixture B into an environment with the temperature of 4-6 ℃ for refrigeration for 20min, and filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110546359.9A CN113456522A (en) | 2021-05-19 | 2021-05-19 | Hand cream with recombinant human collagen as nutrient component and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110546359.9A CN113456522A (en) | 2021-05-19 | 2021-05-19 | Hand cream with recombinant human collagen as nutrient component and preparation method thereof |
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| CN113456522A true CN113456522A (en) | 2021-10-01 |
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| CN202110546359.9A Pending CN113456522A (en) | 2021-05-19 | 2021-05-19 | Hand cream with recombinant human collagen as nutrient component and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176282A (en) * | 2016-08-19 | 2016-12-07 | 山西锦波生物医药股份有限公司 | Protein facial mask liquid and production method |
| CN106309151A (en) * | 2016-08-19 | 2017-01-11 | 山西锦波生物医药股份有限公司 | Protein vitamin pink mask liquid and production method |
| CN108553405A (en) * | 2018-05-31 | 2018-09-21 | 北昊干细胞与再生医学研究院有限公司 | It releives the composition of maintenance skin, cosmetics and preparation method thereof |
| CN110946789A (en) * | 2019-12-31 | 2020-04-03 | 茂名市瑜丰沉香创意产业有限公司 | Hand cream containing agilawood and fullerene and preparation method thereof |
| CN111568830A (en) * | 2020-06-08 | 2020-08-25 | 北昊干细胞与再生医学研究院有限公司 | Skin care composition and preparation method thereof |
| CN111773139A (en) * | 2020-06-15 | 2020-10-16 | 上海兰葹生物科技有限公司 | Skin care product for promoting RNA transcription and preparation process thereof |
| CN111904897A (en) * | 2020-09-16 | 2020-11-10 | 上海海盈通感光材料有限公司 | Nourishing type lip cosmetic and preparation method thereof |
-
2021
- 2021-05-19 CN CN202110546359.9A patent/CN113456522A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176282A (en) * | 2016-08-19 | 2016-12-07 | 山西锦波生物医药股份有限公司 | Protein facial mask liquid and production method |
| CN106309151A (en) * | 2016-08-19 | 2017-01-11 | 山西锦波生物医药股份有限公司 | Protein vitamin pink mask liquid and production method |
| CN108553405A (en) * | 2018-05-31 | 2018-09-21 | 北昊干细胞与再生医学研究院有限公司 | It releives the composition of maintenance skin, cosmetics and preparation method thereof |
| CN110946789A (en) * | 2019-12-31 | 2020-04-03 | 茂名市瑜丰沉香创意产业有限公司 | Hand cream containing agilawood and fullerene and preparation method thereof |
| CN111568830A (en) * | 2020-06-08 | 2020-08-25 | 北昊干细胞与再生医学研究院有限公司 | Skin care composition and preparation method thereof |
| CN111773139A (en) * | 2020-06-15 | 2020-10-16 | 上海兰葹生物科技有限公司 | Skin care product for promoting RNA transcription and preparation process thereof |
| CN111904897A (en) * | 2020-09-16 | 2020-11-10 | 上海海盈通感光材料有限公司 | Nourishing type lip cosmetic and preparation method thereof |
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Application publication date: 20211001 |