CN110934813A - A cosmetic composition containing umbilical cord blood extract and its preparation method - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention belongs to the field of cosmetics, and discloses a cosmetic composition containing an umbilical cord blood extract, which comprises the following raw materials: a split yeast fermentation lysate, umbilical cord extract, placental protein, placental enzyme, and serum protein. The cosmetic composition has the effects of whitening, fading spots, moisturizing, removing acnes, enhancing skin barrier, resisting wrinkles and aging and removing pouches.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a cosmetic composition containing an umbilical cord blood extract and a preparation method thereof.
Background
Stem cells are a cell population with self-renewal, high proliferation and multi-directional differentiation potential, and are the "progenitor cells" and "universal cells" forming various tissues and organs of the human body. Can be divided into embryonic stem cells and adult stem cells according to the development stage of the cell, and can be divided into totipotent stem cells, pluripotent stem cells and unipotent stem cells according to the size of differentiation potential.
The stem cells not only can generate or secrete a large amount of bioactive factors, but also contain rich bioactive substances, and the bioactive factors or substances of the stem cells can effectively regulate and control the cell signal conduction of organisms and activate the stem cells of the human bodies, so that cells with body injury, pathological changes and aging can be physiologically repaired or replaced. For example, stem cells can produce stem cell growth factor (SCF), Nerve Growth Factor (NGF), stromal cell derived growth factor (SDF), vascular endothelial cell growth factor (VEGF), basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF), Epidermal Growth Factor (EGF), interleukin-6 and interleukin-7 (IL-6 and IL-7), megakaryocyte colony stimulating factor (M-CSF), Tumor Necrosis Factor (TNF), Interferon (IFN), and other factors, which have the functions of promoting cell proliferation, differentiation, anti-apoptosis, and the like; stem cells may also produce natural immune proteins such as IgG, IgA, IgM, IgD, IgE, etc., which may protect against or repair damage to cells of the body caused by self and external factors.
Therefore, the bioactive factors generated by the secretion of the stem cells or bioactive substances in the stem cells are utilized to activate the stem cells of the organism, and then the cells with body injury, pathological changes and aging are physiologically repaired or replaced by the stem cells, so that the stem cells have wide application prospects in the fields of disease prevention and treatment, health care and beauty. Most of the stem cell bioactive factors or substances used in the prior art have the following defects: (1) directly extracting by using tissues such as placenta and the like, so that the purity of the obtained stem cell bioactive factor or bioactive substance in the stem cell is low; (2) when stem cell culture amplification is performed using a culture solution containing animal-derived components (for example, using fetal bovine serum), the extracted secretion inevitably contains animal-derived components and even specific viruses present in the animal body, which poses a serious safety risk when applied to clinical care or health care.
The umbilical cord blood is also called placental blood, which is blood in the umbilical cord and in the blood vessel near the fetus of the placenta at the time of birth of a fetus, wherein, the umbilical cord blood has an original cell with differentiation potential, has the capacity of self-renewal and proliferation, and can be differentiated to cells or tissues under the influence or induction of specific factors, namely, the umbilical cord blood stem cells. In the current research, the HSCs/HPCs in the hematopoietic stem cells in the umbilical cord blood have more primitive and stronger proliferation and differentiation capacities, are mainly used for treating blood diseases such as leukemia, lymphoma, anemia and the like, and because the immune function of the umbilical cord blood stem cells is not completely developed, the matching is relatively easy, and the probability is higher among families.
The current methods of using cord blood stem cells are: after matched umbilical cord blood stem cells are injected into a body through buttocks, 10 hundred million stem cells can be added into a receptor, and after the matched umbilical cord blood stem cells successfully survive in the receptor for 100-180 days, the activity of the receptor cells can return to the level of 15 years ago, so that the effects of whitening, removing freckles, removing wrinkles and resisting aging and beautifying are achieved. Because injection is subject to a certain uncertainty and risk and is costly.
Disclosure of Invention
The invention aims to provide a cosmetic composition containing umbilical cord blood extract and a preparation method thereof; the cosmetic composition has effects of whitening skin, removing speckle, supplementing water, repairing, keeping moisture, removing acne, enhancing skin barrier, resisting wrinkle, resisting aging and eliminating pouch.
In order to achieve the purpose, the invention adopts the following technical scheme:
a cosmetic composition containing umbilical cord blood extract comprises the following raw materials: a split yeast fermentation lysate, umbilical cord extract, placental protein, placental enzyme, and serum protein.
Preferably, the cosmetic composition containing the cord blood extract further comprises the following raw materials: water, a humectant, a preservative and an emulsifier.
Preferably, the cosmetic composition containing the cord blood extract is prepared from the following components in parts by weight: 1-6 parts of schizosaccharomyces cerevisiae fermentation product lysate, 1-10 parts of umbilical cord extract, 1-8 parts of placental protein, 1-5 parts of placental enzyme, 0.1-1 part of serum protein, 50-80 parts of water, 3-15 parts of humectant, 0.1-1 part of preservative and 0-15 parts of emulsifier.
Preferably, the method for preparing the schizosaccharomyces cerevisiae fermentation product lysate, the umbilical cord extract, the placental protein and the placental enzyme comprises the following steps: (1) removing wastes from the culture solution of the umbilical cord stem cells and the animal placental cells at 0-4 ℃, centrifuging for 20-30min at the rotating speed of 8000-10000r/min, and collecting supernatant; (2) adding physiological saline, yeast, amino acids, microelements and growth factor into the supernatant, and culturing for 3-5 days to obtain culture solution; (3) heating the culture solution to 85-95 ℃, preserving heat, sterilizing, cooling, adjusting pH, cooling to 0-4 ℃ to remove waste, centrifuging for 20-30min at the rotating speed of 8000-10000r/min, and collecting supernatant to obtain the umbilical cord extract, the lysate of the secondary fission yeast fermentation product, placental protein and placental enzyme.
Preferably, the humectant is selected from at least one of sodium hyaluronate, glycerol or butanediol.
Preferably, the preservative is selected from at least one of phenoxyethanol or caprylyl hydroximic acid.
Preferably, the emulsifier is selected from at least one of isononyl isononanoate, cetearyl alcohol, glyceryl stearate, cetearyl glucoside or polydimethylsiloxane.
A method for preparing a cosmetic composition containing an extract of umbilical cord blood, comprising the steps of:
(1) heating water and humectant, and sterilizing at constant temperature to obtain water phase;
(2) heating the emulsifier, and stirring to obtain an oil phase;
(3) pumping the oil phase into the water phase, cooling, adding the lysate of the secondary fission yeast fermentation product, the umbilical cord extract, the placental protein, the placental enzyme and the serum protein, mixing and stirring to obtain a mixed solution;
(4) adding antiseptic into the mixed solution, stirring, filtering, and aging to obtain cosmetic composition containing umbilical cord blood extract.
Preferably, the temperature of the heating in the step (1) and the step (2) is 75-85 ℃.
Preferably, the heat preservation time of the step (1) is 20-40 min.
Preferably, the stirring time of the step (2) is 8-10 min.
Preferably, the temperature reduction in the step (3) is to reduce the temperature to 35-38 ℃.
Preferably, the aging time in step (4) is 2-4 h.
The invention has the beneficial technical effects that:
1. the cosmetic composition has the effects of whitening, fading spots, moisturizing, removing acnes, enhancing skin barrier, resisting wrinkles and aging and removing pouches.
2. The raw materials of the invention are not directly cord blood stem cells, but are the main components of a schizosaccharomyces cerevisiae fermentation product lysate, a cord extract, placental protein and placental enzyme in a culture solution of the cord blood stem cells, thus reducing the biological toxicity and the use cost of the stem cells, and substances such as moisturizing components, serum protein and the like are added, after being absorbed by skin epidermal cells, the cell activity is rapidly enhanced, the regulation of the damaged tissue cells is inhibited, the proliferation of the damaged tissue cells is promoted, the inflammatory reaction is resisted, the related cell proliferation and migration of inflammation caused by the damaged parts are inhibited, the cell regeneration capacity is enhanced, and the super-strong effects of moisturizing, whitening, moisturizing, acne removing, repairing, anti-aging and the like are achieved.
Detailed Description
For a further understanding of the invention, preferred embodiments of the invention are described below with reference to the examples to further illustrate the features and advantages of the invention, and any changes or modifications that do not depart from the gist of the invention will be understood by those skilled in the art to which the invention pertains, the scope of which is defined by the scope of the appended claims.
Example 1
A cosmetic composition containing an umbilical cord blood extract is prepared from the following components in parts by weight:
a method for preparing a cosmetic composition containing an extract of umbilical cord blood, comprising the steps of:
(1) heating water, glycerol and hyaluronic acid to 80 deg.C, maintaining the temperature for 30min, and sterilizing to obtain water phase;
(2) cooling to 35 deg.C, adding lysate of yeast fermentation product, umbilical cord extract, placental protein, placental enzyme and serum protein, mixing and stirring for 10min to obtain mixed solution;
(3) adding phenoxyethanol into the mixed solution, stirring, filtering with 400 mesh filter cloth, and aging for 2 hr to obtain the cosmetic composition containing the umbilical cord blood extract.
Example 2
A cosmetic composition containing an umbilical cord blood extract is prepared from the following components in parts by weight:
a method for preparing a cosmetic composition containing an extract of umbilical cord blood, comprising the steps of:
(1) heating water, butanediol, glycerol and sodium hyaluronate to 80 deg.C, maintaining the temperature for 30min, and sterilizing to obtain water phase;
(2) heating isononyl isononanoate, cetearyl alcohol, glyceryl stearate, cetearyl glucoside and polydimethylsiloxane to 80 deg.C, and stirring for 8min to obtain oil phase;
(3) pumping out the oil phase, cooling to 35 deg.C, adding the lysate of the fermentation product of the yeast, the umbilical cord extract, the placental protein, the placental enzyme and the serum protein, mixing and stirring for 10min to obtain a mixed solution;
(4) adding caprylyl hydroximic acid into the mixed solution, stirring, filtering with 400-mesh filter cloth, and aging for 2h to obtain the cosmetic composition containing the cord blood extract.
Example 3
A cosmetic composition containing an umbilical cord blood extract is prepared from the following components in parts by weight:
a method for preparing a cosmetic composition containing an extract of umbilical cord blood, comprising the steps of:
(1) heating water, butanediol, glycerol and sodium hyaluronate to 80 deg.C, maintaining the temperature for 30min, and sterilizing to obtain water phase;
(2) heating isononyl isononanoate, cetearyl alcohol, glyceryl stearate, cetearyl glucoside and polydimethylsiloxane to 80 deg.C, and stirring for 8min to obtain oil phase;
(3) pumping out the oil phase, cooling to 35 deg.C, adding the lysate of the fermentation product of the yeast, the umbilical cord extract, the placental protein, the placental enzyme and the serum protein, mixing and stirring for 10min to obtain a mixed solution;
(4) adding caprylyl hydroximic acid into the mixed solution, stirring, filtering with 400-mesh filter cloth, and aging for 2h to obtain the cosmetic composition containing the cord blood extract.
Application testing
30 experimenters, 12 male and 18 female, aged 18-38 years, were recruited into 3 groups of 10 individuals each. The test method comprises the following steps: the test subjects directly use the products of the embodiments 1 to 3 once a day, the face is cleaned before use, a proper amount of the product is uniformly smeared on the skin of the face, and the product is gently massaged until the product is absorbed. The effect of the product is checked after the product is used for one month. The effect of the use is shown in table 4.
TABLE 4 test results
From the test results, the mixed liquid added with the whitening and moisturizing cream has strong water locking and moisturizing effects, can simultaneously whiten, moisturize and delay aging, and is mild to skin and less in irritation.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and they are included in the scope of the present invention.
Claims (10)
1. A cosmetic composition containing an extract of umbilical cord blood, characterized in that: the method comprises the following raw materials: a split yeast fermentation lysate, umbilical cord extract, placental protein, placental enzyme, and serum protein.
2. The cord blood extract-containing cosmetic composition according to claim 1, characterized in that: the method also comprises the following raw materials: water, a humectant, a preservative and an emulsifier.
3. The cord blood extract-containing cosmetic composition according to claim 2, characterized in that: the composition is prepared from the following components in parts by weight: 1-6 parts of schizosaccharomyces cerevisiae fermentation product lysate, 1-10 parts of umbilical cord extract, 1-8 parts of placental protein, 1-5 parts of placental enzyme, 0.1-1 part of serum protein, 50-80 parts of water, 3-15 parts of humectant, 0.1-1 part of preservative and 0-15 parts of emulsifier.
4. The cord blood extract-containing cosmetic composition according to claim 1, characterized in that: the preparation method of the schizosaccharomyces cerevisiae fermentation product lysate, the umbilical cord extract, the placental protein and the placental enzyme comprises the following steps: (1) removing wastes from the culture solution of the umbilical cord stem cells and the animal placental cells at 0-4 ℃, centrifuging for 20-30min at the rotating speed of 8000-10000r/min, and collecting supernatant; (2) adding physiological saline, yeast, amino acids, microelements and growth factor into the supernatant, and culturing for 3-5 days to obtain culture solution; (3) heating the culture solution to 85-95 ℃, preserving heat, sterilizing, cooling, adjusting pH, cooling to 0-4 ℃ to remove waste, centrifuging for 20-30min at the rotating speed of 8000-10000r/min, and collecting supernatant to obtain umbilical cord extract, schizosaccharomyces cerevisiae fermentation product lysate, placental protein and placental enzyme.
5. The cord blood extract-containing cosmetic composition according to claim 3, characterized in that: the humectant is at least one of sodium hyaluronate, glycerin, 1, 3-propylene glycol or butanediol.
6. The cord blood extract-containing cosmetic composition according to claim 3, characterized in that: the preservative is at least one of phenoxyethanol or caprylyl hydroximic acid.
7. The cord blood extract-containing cosmetic composition according to claim 3, characterized in that: the emulsifier is at least one of isononyl isononanoate, cetearyl alcohol, glyceryl stearate, cetearyl glucoside or polydimethylsiloxane.
8. The method for preparing a cord blood extract-containing cosmetic composition according to any one of claims 2, 3, 5, 6 and 7, wherein: the method comprises the following steps:
(1) heating water and humectant, and sterilizing at constant temperature to obtain water phase;
(2) heating the emulsifier, and stirring to obtain an oil phase;
(3) pumping the oil phase into the water phase, cooling, adding the lysate of the secondary fission yeast fermentation product, the umbilical cord extract, the placental protein, the placental enzyme and the serum protein, mixing and stirring to obtain a mixed solution;
(4) adding antiseptic into the mixed solution, stirring, filtering, and aging to obtain cosmetic composition containing umbilical cord blood extract.
9. The method of claim 8, wherein: the heating temperature of the step (1) and the step (2) is 75-85 ℃.
10. The method of claim 8, wherein: and (3) cooling to 35-38 ℃.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111449978A (en) * | 2020-04-10 | 2020-07-28 | 刘书莲 | Formula and application method of skin-soothing and skin-beautifying lotion |
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| CN109453095A (en) * | 2018-11-26 | 2019-03-12 | 广州秉科医药科技有限公司 | A kind of niacinamide stoste and preparation method thereof |
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| CN111449978A (en) * | 2020-04-10 | 2020-07-28 | 刘书莲 | Formula and application method of skin-soothing and skin-beautifying lotion |
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Application publication date: 20200331 |