KR102337124B1 - Composite powder for improving hair loss and hair cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a composite powder for improving hair loss comprising adenosine, niacinamide and cyclodextrin. More specifically, the present invention relates to a composite powder for improving hair loss comprising: adenosine; niacinamide; and cyclodextrin, wherein with respect to 100 wt% of the composite powder for improving hair loss, the proportions of adenosine, niacinamide, and cyclodextrin are 10-50 wt%, 25-70 wt%, and 5-45 wt%, respectively. Furthermore, the adenosine powder for improving hair loss may have a dissolution rate of 1 mg/sec or more when 2.5 g of the adenosine powder being dissolved in 100 g of a water-based solvent at 25°C.

Description

Composite powder for improving hair loss and hair cosmetic composition comprising the same

The present invention relates to a complex powder for improving hair loss and a cosmetic composition for hair comprising the same.

Hair loss refers to a condition in which there is little or no hair in the area where hair should normally exist. The cause of hair loss is not only genetic causes, the action of male hormones, but also endocrine diseases, nutritional deficiencies, drug use, childbirth, fever, and severe severe surgery such as surgery. It is known that factors such as physical and mental stress are complexly involved and cause hair loss symptoms. Recently, as well as male pattern hair loss, the female hair loss population is also increasing, and the population suffering from abnormal symptoms of the scalp and hair as described above is increasing, and the age is also decreasing.

Currently, research for preventing and improving hair loss is accelerated at home and abroad, and various products are being developed, but there is a limit to satisfying both the hair loss improvement efficacy and safety for the human body. In addition, since most of the existing products for preventing and improving hair loss were developed with a mechanism to suppress male hormones by focusing on male pattern hair loss, problems with side effects such as decreased libido, itching of the scalp, erythema, peeling of the epidermis, and contact dermatitis There is a limit to solving female pattern hair loss.

Therefore, it is necessary to develop a new product that can prove safety and breakthrough effects for both men and women. To this end, it is necessary to fundamentally improve the mechanism of hair loss and to improve hair loss by facilitating the expression of hair growth factors. necessary.

On the other hand, it has excellent stability and anti-wrinkle effect on the human body as well as safety to the human body when penetrating the skin. One study has been reported. However, since adenosine has very low water solubility, there is a problem that recrystallization or precipitation occurs in cosmetic or pharmaceutical compositions, making it difficult to contain in high concentrations. Therefore, it has to be included in a low content of less than the effective concentration in the composition, and there is a limitation in not being able to implement a satisfactory effect.

In order to solve this problem, attempts are being made to improve the aqueous solubility of adenosine by adding various hydrotropes. However, such attempts still have disadvantages in the manufacturing process due to the slow dissolution rate, and there is a limit to market competitiveness due to high energy cost and production cost.

That is, it is required to develop a hair loss improvement product that can satisfy all of the excellent hair loss improvement effect, excellent stability, market competitiveness, and usability.

Journal of Dermatology. 2008, 35, pp. 763-767.

The present invention has been devised to solve the above problems, and an object of the present invention is to provide a complex powder for improving hair loss that can be used easily by quickly dissolving adenosine in a high content.

In addition, the present invention provides a cosmetic composition for hair comprising the complex powder for improving hair loss.

For the above purpose, the present invention is a complex powder for improving hair loss comprising adenosine, niacinamide and cyclodextrin, based on the total weight of the complex powder for improving hair loss, 10 to 50 wt% of adenosine, 25 to 70 wt% of niacinamide , cyclodextrin 5 to 45% by weight, wherein the adenosine powder for improving hair loss has a dissolution rate of 1 mg/sec or more when dissolving 2.5 g in 100 g of an aqueous solvent at 25 ° C. Provides a complex powder for improving hair loss .

The adenosine and niacinamide according to an embodiment of the present invention may be included in a weight ratio of 1:1 to 1:3.

The niacinamide according to an embodiment of the present invention may be isoniacinamide.

The cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

The aqueous solvent according to an embodiment of the present invention may include distilled water.

The complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodium salt (Disodium EDTA).

In addition, the present invention provides a cosmetic composition for hair, comprising the complex powder for improving hair loss.

The cosmetic composition for hair according to an embodiment of the present invention may include shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack and hair cream.

Adenosine may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition for hair according to an embodiment of the present invention.

In addition, the present invention comprises the steps of (a) preparing a hydrotrope complex by adding adenosine, niacinamide and cyclodextrin to a powder mixer and uniformly mixing under humidifying conditions; And (b) drying the hydrotrope complex; provides a method for producing a complex powder for improving hair loss, including.

The powder mixer of step (a) according to an embodiment of the present invention may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer, or a Coulter-type mixer.

The humidification condition of step (a) according to an embodiment of the present invention may be a relative humidity of 80 to 95%.

The hydrotrope complex of step (a) according to an embodiment of the present invention may be an aggregate in which adenosine, niacinamide and cyclodextrin are aggregated.

The complex powder for improving hair loss according to the present invention can implement excellent solubility and dissolution rate not only in water but also in cosmetic compositions for hair such as shampoo.

Specifically, the complex powder for improving hair loss according to the present invention can be rapidly dissolved in shampoos used every day in daily life, so that it is excellent in usability, and contains a high content of adenosine, thereby exhibiting excellent hair loss improvement effect. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization of adenosine even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of the excellent hair loss improvement effect, excellent stability, market competitiveness and usability.

1 shows the formulation of a skin toner used for solubility evaluation.
Figure 2 shows the formulation of the shampoo used for solubility evaluation.

Hereinafter, the present invention will be described in more detail. If there is no other definition in the technical and scientific terms used at this time, it has the meaning commonly understood by those of ordinary skill in the art to which this invention belongs, and may unnecessarily obscure the subject matter of the present invention in the following description. A description of possible known functions and configurations will be omitted.

In the present specification, the units used without special mention are based on weight, for example, the unit of % or ratio means weight % or weight ratio, and unless otherwise defined, weight % means that any one component of the composition is present in the composition. % by weight in

As used herein, the term “comprises” is an open-ended description having an equivalent meaning to expressions such as “comprises”, “contains”, “has” or “characterizes”, and is an element not listed in addition; Materials or processes are not excluded.

As used herein, the term “niacinamide” refers to 1,3-niacinamide or 1,4-niacinamide (isoniacinamide).

Hereinafter, the present invention will be specifically described.

The complex powder for improving hair loss according to the present invention may include adenosine, niacinamide and cyclodextrin.

Although the adenosine has been proven to have an excellent effect in improving and treating hair loss, recrystallization or precipitation occurs due to the very low solubility of adenosine, and there is a problem in that it is difficult to contain a high concentration of adenosine. Therefore, it has to be included in a low content of less than the effective concentration in the product, and there is a limitation in not being able to realize a satisfactory effect.

The complex powder for improving hair loss according to the present invention has significantly improved solubility and dissolution rate of adenosine, and by using it, it is possible to provide a cosmetic composition for hair excellent in both stability and hair loss improvement effect.

Specifically, the complex powder for improving hair loss according to an embodiment of the present invention may include 10 to 50% by weight of adenosine, 25 to 70% by weight of niacinamide, and 5 to 45% by weight of cyclodextrin based on the total weight. The adenosine powder for improving hair loss may have a dissolution rate of 1 mg/sec or more when dissolving 2.5 g in 100 g of an aqueous solvent at 25 ° C., specifically 5 mg/sec or more, or 10 mg/sec or more, It may be, but is not limited to, 100 mg/sec or less, 50 mg/sec or less, or 20 mg/sec or less.

The adenosine according to an embodiment of the present invention, specifically, may be included in an amount of 10 to 40% by weight, more preferably 20 to 35% by weight, based on the total weight of the complex powder for improving hair loss. In the above numerical range, the desired effect in the present invention without compromising the stability of the formulation, that is, it is preferable to show remarkable improvement in hair loss and hair growth use.

The adenosine promotes the expression of various growth factors in the scalp, such as Vascular Endothelial Growth Factor (VEGF) and fibroblast growth factor-7 (FGF-7), and hair growth. It has an excellent effect in helping hair growth and thickening the diameter (thickness) of the hair. VEGF is an important growth factor that affects hair growth by helping active substance exchange between capillaries and peripheral nerve cells of the scalp. . That is, by promoting the expression of VEFG, it is possible to improve hair loss by forming new blood vessels around the hair follicle and promoting blood circulation. As a fibroblast growth factor, FGF-7 can help improve hair loss by stimulating hair growth and maintaining hair follicles in the growth phase by participating in promoting hair follicle differentiation.

The niacinamide according to an embodiment of the present invention may be included in an amount of 25 to 70% by weight, preferably 30 to 70% by weight, more preferably 30 to 60% by weight based on the total weight of the complex powder for improving hair loss. may be included. Specifically, the complex powder for improving hair loss according to an embodiment of the present invention may include the adenosine and niacinamide in a weight ratio of 1:1 to 1:3, and it is particularly preferable to include it in a weight ratio of 1:1 to 1:2.5. desirable.

The complex powder for improving hair loss according to an embodiment of the present invention contains niacinamide in the above numerical range, thereby improving the solubility of adenosine and at the same time providing a synergistic effect with adenosine in the hair loss improvement effect.

Specifically, the niacinamide (niacinamide, nicotinamide, nicotamide) is a generic term for nicotinic acid and nicotinic acid amide, belongs to vitamin B group, and supplies nutrients to the scalp and hair and prevents oxidation of components It helps to maintain product stability. In addition, since niacinamide has a hydrotropy property, it can interact with adenosine to significantly improve the solubility of adenosine and to contain adenosine in a high concentration in the product.

Specifically, the niacinamide according to an embodiment of the present invention may be isoniacinamide in terms of improving the solubility and dissolution rate of adenosine. Since the complex powder for improving hair loss according to the present invention contains isoniacinamide, it may be advantageous to effectively form a hydrotrope complex with adenosine, thereby further improving the solubility and dissolution rate of adenosine.

The cyclodextrin according to an embodiment of the present invention may be included in an amount of 5 to 45 wt%, preferably 10 to 45 wt%, more preferably 20 to 40 wt%, based on the total weight of the complex powder for improving hair loss. can be included as

The cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

The complex powder for improving hair loss according to an embodiment of the present invention contains cyclodextrin in the above numerical range, thereby realizing a synergistic effect with niacinamide to improve solubility of adenosine, as well as improving product stability and hair loss The effect can be improved at the same time.

Specifically, the complex powder for improving hair loss according to the present invention can significantly improve the dissolution rate by forming a hydrotrope complex of adenosine, niacinamide and cyclodextrin, and can prevent precipitation or recrystallization of adenosine during long-term storage. . In addition, it is possible to protect the efficacy of adenosine from being oxidized or from being exposed to an external environment, thereby maintaining excellent product stability and hair loss improvement effect.

The complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodium salt (Disodium EDTA, EDTA 2Na) as a stabilizer.

The complex powder for improving hair loss according to the present invention has the above-described structural characteristics, and thus the solubility and dissolution rate of adenosine can be significantly improved. Specifically, the solubility of adenosine in water at room temperature (25 ℃) is known to be 0.26% by weight, but adenosine in the complex powder for improving hair loss according to the present invention has a solubility in water at room temperature (25 ℃) of 1% by weight is significantly improved, and precipitation or recrystallization does not occur.

The complex powder for improving hair loss according to an embodiment of the present invention has very high solubility in water as well as in cosmetic compositions for hair such as shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack and hair cream. great. Specifically, the cosmetic composition for hair may contain 0.1 to 5% by weight of adenosine based on the total weight of the composition, preferably 0.5 to 3% by weight, more preferably 0.5 to 2% by weight.

Accordingly, the complex powder for improving hair loss according to the present invention can be easily used by dissolving it in shampoos used every day in daily life, so it has excellent usability, and can contain a high content of adenosine, thereby exhibiting excellent hair loss improvement effect. have. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of the excellent hair loss improvement effect, excellent stability, market competitiveness and usability.

In addition, the present invention comprises the steps of (a) preparing a hydrotrope complex by adding adenosine, niacinamide and cyclodextrin to a powder mixer and uniformly mixing under humidifying conditions; And (b) drying the hydrotrope complex; provides a method for producing a complex powder for improving hair loss comprising.

Specifically, the step (a) is a step of uniformly mixing the raw materials before the humidification condition, and may include the step of mixing the raw materials evenly for 30 minutes to 2 hours at room temperature (25 ° C.) by putting the raw materials in a powder mixer. The powder mixer is not particularly limited as long as it is a powder mixer commonly used in the art, but as a non-limiting example, it may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer or a Coulter-type mixer, and a double cone mixer. more preferably.

The humidification condition of step (a) according to an embodiment of the present invention may be performed under a condition of 80 to 95% relative humidity, more specifically 85 to 95%, and 1 hour to 3 hours at room temperature (25 ° C.) It can be uniformly mixed to form a hydrotrope complex.

The hydrotrope complex prepared in step (a) according to an embodiment of the present invention may be an aggregate in which adenosine, niacinamide and cyclodextrin are aggregated. The complex powder for improving hair loss according to an embodiment of the present invention can significantly improve the solubility and dissolution rate of adenosine by forming a hydrotrope complex through the step (a).

The drying method in step (b) according to an embodiment of the present invention is not particularly limited, and a known method such as blow drying or reduced pressure drying may be used, and it is more preferable to use reduced pressure drying. The drying temperature may be 30 to 150 °C, preferably 40 to 120 °C, more preferably 50 to 100 °C. The drying time is not particularly limited, but by performing for 2 to 5 hours, the complex powder for improving hair loss can be sufficiently dried.

Hereinafter, the present invention will be described in more detail based on Comparative Examples and Examples. However, the following Examples and Comparative Examples are only examples for explaining the present invention in more detail, and the present invention is not limited by the following Examples and Comparative Examples.

[Examples 1 to 5 and Comparative Examples 1 to 5]

Preparation of complex powder for hair loss improvement

Each raw material was put into a double cone mixer at the composition ratio shown in Table 1 below, and blended at room temperature (25° C.) at 10 rpm for 120 minutes. After that, the hydrotrope composite was prepared by spraying steam at 10 rpm for 2 hours under a 90% relative humidity condition, and then drying under reduced pressure at 50° C. for 3 hours to prepare a complex powder for improving hair loss.

Furtherance
(content, wt%) iso
niacinamide adenosine HP-b-CD b-CD EDTA-2Na Example 1 60 30 10 0 0 Example 2 57.5 30 9 3.5 0 Example 3 44 30 15 10 One Example 4 30 30 15 24 One Example 5 54 30 5 10 One Comparative Example 1 20 30 10 39 One Comparative Example 2 10 30 0 59 One Comparative Example 3 0 30 0 69 One Comparative Example 4 0 30 69 0 One Comparative Example 5 0 30 35 34 One

[Comparative Example 6]

In the composition ratio of Example 1, each raw material was put into a double cone mixer and dry-blended at 10 rpm for 2 hours at room temperature (25° C.) to prepare a complex powder for improving hair loss.

Dissolution rate evaluation

2.5 g of the complex powder for improving hair loss prepared in Examples 1 to 5 and Comparative Examples 1 to 7 was added to 100 g of distilled water at room temperature (25° C.) and stirred at 500 rpm to observe the rate of complete dissolution, and the following evaluation The results evaluated based on the criteria are shown in Table 2 below.

◎: completely dissolved within 150 seconds

○: Completely dissolved within 150 seconds to 5 minutes

△: completely dissolved within 5 to 10 minutes

X: It takes more than 10 minutes to completely dissolve

Example 1 Example 2 Example 3 Example 4 Example 5 dissolution rate ○ ◎ ◎ ◎ ◎ Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 dissolution rate △ X X △ △ X

Solubility evaluation

1) Evaluation of solubility in distilled water

After completely dissolving 0.25 g of the complex powder for hair loss improvement prepared in Examples 1 to 5 and Comparative Examples 1 to 6 in 10 g of distilled water, 4 ℃, 25 ℃, 50 ℃, cycle (-18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ for 24 hours at each temperature, it takes 1 hour when changing the temperature condition) and observed for precipitation by keeping it under the conditions) did

1A: Precipitation occurred after 1 week of storage

2A: Precipitation occurred after 2 weeks of storage

3A: Precipitation occurred after 3 weeks of storage

4A: Precipitation occurs after 4 weeks of storage

-: No precipitation

4 ℃ 25℃ 50 ℃ cycle Example 1 - - - - Example 2 - - - - Example 3 - - - - Example 4 - - - - Example 5 - - - - Comparative Example 1 2A 3A - 2A Comparative Example 2 1A 3A 4A 1A Comparative Example 3 1A 2A 4A 1A Comparative Example 4 2A 3A 4A 1A Comparative Example 5 1A 2A 4A 2A Comparative Example 6 4A - - 4A

2) Solubility evaluation for skin toner and shampoo

After dissolving 0.25 g of the complex powder for improving hair loss prepared in Examples 1 to 5 and Comparative Examples 1 to 6 in 10 g of skin toner and shampoo, respectively, 4 ℃, 25 ℃, 50 ℃, cycle (-18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ 24 hours for each temperature, 1 hour when changing temperature conditions) 4 is described. The formulations of the skin toner and shampoo used for evaluation are shown in FIGS. 1 and 2, respectively.

1A: Precipitation occurred after 1 week of storage

2A: Precipitation occurs after 2 weeks of storage

3A: Precipitation occurred after 3 weeks of storage

4A: Precipitation occurs after 4 weeks of storage

-: No precipitation

4 ℃ 25℃ 50 ℃ cycle toner shampoo toner shampoo toner shampoo toner shampoo Example 1 - - - - - - - - Example 2 - - - - - - - - Example 3 - - - - - - - - Example 4 - - - - - - - Example 5 - - - - - - - - Comparative Example 1 2A 2A 3A 3A - - 2A 2A Comparative Example 2 1A 1A 3A 3A 4A 4A 1A 1A Comparative Example 3 1A 1A 2A 2A 4A 4A 1A 1A Comparative Example 4 2A 2A 3A 3A 4A 4A 1A 1A Comparative Example 5 1A 1A 2A 2A 4A 4A 2A 2A Comparative Example 6 4A 4A - - - - 4A 4A

It was confirmed that the complex powder for improving hair loss according to the present invention was remarkably excellent both in dissolution rate and solubility. Specifically, as shown in Table 2, the composite powder for improving hair loss of Examples 1 to 5 had a very good dissolution rate in distilled water and was completely dissolved (2.5 wt%) within 150 seconds. On the other hand, the complex powder for improving hair loss of Comparative Examples 1 to 6 took 5 minutes or more than 10 minutes to completely dissolve.

In addition, as shown in Tables 3 and 4 above, the complex powder for improving hair loss of Examples 1 to 5 has excellent solubility in distilled water as well as skin toner and shampoo, so that 4 ℃, 25 ℃, 50 ℃, cycle (- 18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ 24 hours for each temperature, it takes 1 hour to change the temperature condition), even when stored for 4 weeks, no precipitation occurred. On the other hand, in Comparative Examples 1 to 6, it was found that the precipitation phenomenon occurred even at a high temperature (50 ° C.), so that the stability of the product was significantly lowered.

That is, the complex powder for improving hair loss according to the present invention can be easily used by dissolving it in shampoos used every day in daily life, so it has excellent usability, and contains a high content of adenosine, so it can exhibit excellent hair loss improvement effect. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of the excellent hair loss improvement effect, excellent stability, market competitiveness and usability.

Claims (13)

A complex powder for improving hair loss containing adenosine, isoniacinamide and cyclodextrin,
It contains 10 to 50% by weight of adenosine, 25 to 70% by weight of niacinamide, and 5 to 45% by weight of cyclodextrin with respect to the total weight of the complex powder for improving hair loss, and the complex powder for improving hair loss is 100 g of an aqueous solvent at 25 ° C. A complex powder for improving hair loss that has a dissolution rate of 1 mg/sec or more when dissolving 2.5 g. The method of claim 1,
A complex powder for improving hair loss, comprising the adenosine and isoniacinamide in a weight ratio of 1:1 to 1:3. delete The method of claim 1,
The cyclodextrin is beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin, the complex powder for improving hair loss. The method of claim 1,
The aqueous solvent comprises distilled water, a complex powder for improving hair loss. The method of claim 1,
A complex powder for improving hair loss, further comprising ethylenediaminetetraacetic acid sodium salt (Disodium EDTA). A cosmetic composition for hair, comprising the complex powder for improving hair loss according to any one of claims 1, 2, and 4 to 6. 8. The method of claim 7,
The cosmetic composition for hair includes shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack and hair cream. 8. The method of claim 7,
A cosmetic composition for hair comprising 0.1 to 5% by weight of adenosine based on the total weight of the cosmetic composition for hair. (a) preparing a hydrotrope complex by adding adenosine, isoniacinamide and cyclodextrin to a powder mixer and uniformly mixing under humidifying conditions; and
(b) drying the hydrotrope complex; 11. The method of claim 10,
The powder mixer of step (a) is a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer or a Coulter-type mixer, a method of manufacturing a complex powder for improving hair loss. 11. The method of claim 10,
The humidification condition of step (a) is 80 to 95% relative humidity, the method for producing a complex powder for improving hair loss. 11. The method of claim 10,
The hydrotrope complex of step (a) is an aggregate in which adenosine, isoniacinamide and cyclodextrin are aggregated, a method of manufacturing a complex powder for improving hair loss.

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