WO2022239914A1 - Composite powder for alleviation of hair loss and hair cosmetic composition containing same - Google Patents

Abstract

The present invention relates to a composite powder comprising adenosine, niacinamide, and cyclodextrin for alleviation of hair loss. Specifically, the composite powder for alleviation of hair loss comprises 10 to 50 wt% of adenosine, 25 to 70 wt% of niacinamide, and 5 to 45wt% of cyclodextrin based on the total weight thereof, and the adenosine powder for alleviation of hair loss may have a dissolution rate of 1 mg/sec or higher when 2.5g thereof is dissolved at 25°C in 100g of an aqueous solvent.

Description

Complex powder for improving hair loss and cosmetic composition for hair containing the same

The present invention relates to a complex powder for improving hair loss and a cosmetic composition for hair comprising the same.

Hair loss refers to a condition in which there is little or no hair in the area where hair should normally exist. The causes of hair loss include genetic causes, the action of male hormones, as well as severe causes such as endocrine diseases, nutritional deficiencies, drug use, childbirth, fever, and surgery. It is known that factors such as physical and mental stress are complexly involved to show hair loss symptoms. In recent years, not only male pattern baldness but also female hair loss is on the rise, and the number of people suffering from abnormal scalp and hair symptoms is increasing and their age is also getting lower.

Currently, research for preventing and improving hair loss at home and abroad has been accelerated and various products have been developed, but there are limitations in satisfying both the efficacy of improving hair loss and safety for the human body. In addition, since most of the existing products for preventing and improving hair loss were developed with a mechanism to suppress male hormones with an emphasis on male pattern hair loss, problems accompanied by side effects such as decreased libido, itching of the scalp, erythema, peeling of the epidermis, and contact dermatitis There is, and there is a limit to solving female pattern hair loss.

Therefore, it is necessary to develop new products that can demonstrate safety and groundbreaking effects for both men and women. To this end, it should be possible to improve hair loss by fundamentally improving the mechanism of hair loss and promoting the expression of hair growth factors. In addition, it is necessary to develop products that can be easily used in daily life and have excellent usability and can be managed consistently. need.

On the other hand, it has excellent stability and anti-wrinkle effect on the human body, as well as excellent safety on the human body when penetrating into the skin, proving the hair loss improvement and hair growth effect of adenosine, a substance notified as a raw material for wrinkle improvement. One study result has been reported. However, since adenosine has a very low water solubility, recrystallization or precipitation occurs in cosmetic compositions or pharmaceutical compositions, and it is difficult to contain adenosine at high concentrations. Therefore, it is inevitable to be included in a low content of less than the effective concentration in the composition, and there is a limit to implementing a satisfactory effect.

In order to solve this problem, attempts to improve the water solubility of adenosine by adding various hydrotrope agents have been continued. However, these attempts still have disadvantages in the manufacturing process due to the slow dissolution rate, and there are limits to market competitiveness due to high energy and production costs.

That is, it is required to develop a hair loss improvement product that can satisfy all of the excellent hair loss improvement effect, excellent stability, market competitiveness and usability.

The present invention has been made to solve the above problems, and an object of the present invention is to provide a complex powder for improving hair loss that can be easily used by rapidly dissolving a high content of adenosine.

In addition, the present invention provides a cosmetic composition for hair comprising the complex powder for improving hair loss.

For the purpose described above, the present invention is a complex powder for improving hair loss containing adenosine, niacinamide and cyclodextrin, comprising 10 to 50% by weight of adenosine and 25 to 70% by weight of niacinamide, based on the total weight of the complex powder for improving hair loss. , Contains 5 to 45% by weight of cyclodextrin, and the adenosine powder for improving hair loss has a dissolution rate of 1 mg/sec or more when 2.5 g is dissolved in 100 g of an aqueous solvent at 25 ° C., providing a complex powder for improving hair loss .

According to an embodiment of the present invention, the adenosine and niacinamide may be included in a weight ratio of 1:1 to 1:3.

The niacinamide according to an embodiment of the present invention may be isoniacinamide.

The cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

The aqueous solvent according to an embodiment of the present invention may include distilled water.

The complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodum salt (Disodium EDTA).

In addition, the present invention provides a cosmetic composition for hair comprising the complex powder for improving hair loss.

The cosmetic composition for hair according to an embodiment of the present invention may include shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack, and hair cream.

Adenosine may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition for hair according to an embodiment of the present invention.

In addition, the present invention comprises the steps of (a) preparing a hydrotrope complex by introducing adenosine, niacinamide and cyclodextrin into a powder mixer and uniformly mixing them under humid conditions; And (b) drying the hydrotrope complex; it provides a method for producing a complex powder for improving hair loss, including.

The powder mixer of step (a) according to an embodiment of the present invention may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer, or a coulter mixer.

The humidification condition of step (a) according to an embodiment of the present invention may be 80 to 95% relative humidity.

According to an embodiment of the present invention, the hydrotrope complex of step (a) may be an aggregate in which adenosine, niacinamide, and cyclodextrin are aggregated.

The complex powder for improving hair loss according to the present invention can implement excellent solubility and dissolution rate in water as well as cosmetic compositions for hair such as shampoo.

Specifically, the complex powder for improving hair loss according to the present invention is rapidly dissolved in a shampoo used every day in daily life and has excellent usability, and can exhibit an excellent hair loss improvement effect by including a high content of adenosine. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization of adenosine even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.

Figure 1 shows the formulation of the skin toner used for solubility evaluation.

Figure 2 shows the formulation of the shampoo used for solubility evaluation.

Hereinafter, the present invention will be described in more detail. If there is no other definition in the technical terms and scientific terms used at this time, they have meanings commonly understood by those of ordinary skill in the art to which this invention belongs, and will unnecessarily obscure the gist of the present invention in the following description. Descriptions of possible known functions and configurations are omitted.

Units used herein without special mention are based on weight, and as an example, the unit of % or ratio means weight% or weight ratio, and unless otherwise defined, weight% means that any one component of the entire composition is included in the composition. It means the weight percent occupied by

The term "includes" in the present specification is an open description having the same meaning as expressions such as "includes", "includes", "has" or "characterized by", and elements not additionally listed, No materials or processes are excluded.

As used herein, the term “niacinamide” means 1,3-niacinamide or 1,4-niacinamide (isoniacinamide).

Hereinafter, the present invention will be specifically described.

The complex powder for improving hair loss according to the present invention may include adenosine, niacinamide and cyclodextrin.

Although it has been proven that adenosine has an excellent effect on improving and treating hair loss, recrystallization or precipitation occurs due to the very low solubility of adenosine, and it is difficult to contain a high concentration of adenosine. Therefore, it is inevitable to be included in a low content less than the effective concentration in the product, and there is a limit to implementing a satisfactory effect.

The complex powder for improving hair loss according to the present invention is one in which the solubility and dissolution rate of adenosine are significantly improved, and a cosmetic composition for hair excellent in both stability and hair loss improving effect can be provided using this.

Specifically, the complex powder for improving hair loss according to an embodiment of the present invention may contain 10 to 50% by weight of adenosine, 25 to 70% by weight of niacinamide, and 5 to 45% by weight of cyclodextrin, based on the total weight. The adenosine powder for improving hair loss may have a dissolution rate of 1 mg/sec or more when dissolving 2.5 g in 100 g of an aqueous solvent at 25 ° C., specifically, 5 mg/sec or more, or 10 mg/sec or more, It may be, without limitation, 100 mg/sec or less, 50 mg/sec or less, or 20 mg/sec or less.

Specifically, the adenosine according to an embodiment of the present invention may be included in 10 to 40% by weight, more preferably 20 to 35% by weight based on the total weight of the complex powder for improving hair loss. In the above numerical range, it is preferable to show remarkable effects in the present invention, that is, hair loss improvement and hair growth use, without compromising the stability of the formulation.

The adenosine promotes the expression of various growth factors in the scalp, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor-7 (FGF-7), and hair growth It has an excellent effect in helping to thicken the diameter (thickness) of the hair. VEGF is an important growth factor that affects hair growth by helping active material exchange between capillaries and peripheral nerve cells in the scalp. It can increase the thickness and distribution of hair by increasing the size and distribution of capillaries in hair follicles and strengthen hair follicles. . That is, by promoting the expression of VEFG, it is possible to improve hair loss by forming new blood vessels around hair follicles and promoting blood circulation. FGF-7 is a fibroblast growth factor, which is involved in promoting hair follicle cell differentiation to maintain hair follicles in the growing phase and stimulates hair growth to help improve hair loss.

The niacinamide according to an embodiment of the present invention may be included in 25 to 70% by weight, preferably 30 to 70% by weight, more preferably 30 to 60% by weight, based on the total weight of the complex powder for improving hair loss. can be included Specifically, the complex powder for improving hair loss according to an embodiment of the present invention may include the adenosine and niacinamide in a weight ratio of 1:1 to 1:3, and especially containing the adenosine and niacinamide in a weight ratio of 1:1 to 1:2.5 desirable.

The complex powder for improving hair loss according to an embodiment of the present invention includes niacinamide in the above numerical range, thereby improving the solubility of adenosine and at the same time providing a synergistic effect with adenosine in the effect of improving hair loss.

Specifically, the niacinamide (nicotinamide, nicotinamide, nicotamide) is a generic term for nicotinic acid and nicotinic acid amide, belongs to the vitamin B group, supplies nutrients to the scalp and hair, and prevents oxidation of components. It helps to maintain product stability. In addition, since niacinamide has a hydrotropic property, it can significantly improve the solubility of adenosine by interacting with adenosine and make it possible to contain adenosine in a high concentration in a product.

Specifically, the niacinamide according to an embodiment of the present invention may be isoniacinamide in terms of improving the solubility and dissolution rate of adenosine. By including isoniacinamide, the complex powder for improving hair loss according to the present invention may be advantageous in forming an effective hydrotrope complex with adenosine, and thus, the solubility and dissolution rate of adenosine may be further improved.

The cyclodextrin according to an embodiment of the present invention may be included in an amount of 5 to 45% by weight, preferably 10 to 45% by weight, more preferably 20 to 40% by weight, based on the total weight of the complex powder for improving hair loss. can be included as

The cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.

The complex powder for improving hair loss according to an embodiment of the present invention contains cyclodextrin in the above numerical range, thereby realizing a synergistic effect with niacinamide to improve the solubility of adenosine, as well as product stability and hair loss improvement effect can be enhanced at the same time.

Specifically, the complex powder for improving hair loss according to the present invention can significantly improve the dissolution rate by forming a hydrotrope complex of adenosine, niacinamide and cyclodextrin, and can prevent precipitation or recrystallization of adenosine during long-term storage. . In addition, it is possible to maintain excellent stability and hair loss improving effect of the product by protecting adenosine from oxidation or deterioration of efficacy due to exposure to the external environment.

The complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodum salt (Disodium EDTA, EDTA 2Na) as a stabilizer.

The complex powder for improving hair loss according to the present invention has the above-described structural characteristics, so that the solubility and dissolution rate of adenosine can be remarkably improved. Specifically, the solubility of adenosine in water at room temperature (25 ° C.) has been known to be 0.26% by weight, but the solubility of adenosine in water at room temperature (25 ° C.) in the complex powder for improving hair loss according to the present invention is 1% by weight. up to, and no precipitation or recrystallization occurs.

The complex powder for improving hair loss according to an embodiment of the present invention has very high solubility in hair cosmetic compositions such as shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack, and hair cream as well as water. great. Specifically, the cosmetic composition for hair may include 0.1 to 5% by weight of adenosine, preferably 0.5 to 3% by weight, more preferably 0.5 to 2% by weight based on the total weight of the composition.

Accordingly, the complex powder for improving hair loss according to the present invention can be easily used by dissolving in a shampoo used every day in daily life, and thus not only has excellent usability, but can also contain a high content of adenosine, thereby exhibiting an excellent hair loss improvement effect. have. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.

In addition, the present invention comprises the steps of (a) preparing a hydrotrope complex by introducing adenosine, niacinamide and cyclodextrin into a powder mixer and uniformly mixing them under humid conditions; and (b) drying the hydrotrope complex.

Specifically, the step (a) is a step of uniformly mixing the raw materials before humidifying conditions, and may include mixing the raw materials in a powder mixer and mixing them evenly at room temperature (25 ° C.) for 30 minutes to 2 hours. The powder mixer is not particularly limited as long as it is a powder mixer commonly used in the art, but as a non-limiting example, it may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer, or a coulter type mixer, and a double cone mixer it is more preferable

The humidification conditions of the step (a) according to an embodiment of the present invention may be performed at a relative humidity of 80 to 95%, more specifically, at 85 to 95%, and at room temperature (25 ° C.) for 1 hour to 3 hours A hydrotrope complex can be formed by uniformly blending.

The hydrotrope complex prepared in step (a) according to an embodiment of the present invention may be an aggregate in which adenosine, niacinamide, and cyclodextrin are aggregated. The complex powder for improving hair loss according to an embodiment of the present invention can significantly improve the solubility and dissolution rate of adenosine by forming a hydrotrope complex through the step (a).

The drying method of the step (b) according to an embodiment of the present invention is not particularly limited, and a known method such as blow drying or reduced pressure drying may be used, and it is more preferable to use reduced pressure drying. The drying temperature may be 30 to 150 °C, preferably 40 to 120 °C, and more preferably 50 to 100 °C. The drying time is not particularly limited, but the complex powder for improving hair loss can be sufficiently dried by performing the drying for 2 to 5 hours.

Hereinafter, the present invention will be described in more detail based on Examples and Comparative Examples. However, the following Examples and Comparative Examples are only one example for explaining the present invention in more detail, and the present invention is not limited by the following Examples and Comparative Examples.

[Examples 1 to 5 and Comparative Examples 1 to 5]

Manufacturing of complex powder for hair loss improvement

In the composition ratio shown in Table 1 below, each raw material was put into a double cone mixer and mixed at 10 rpm for 120 minutes at room temperature (25 ° C.). Thereafter, steam was sprayed and mixed at 10 rpm for 2 hours under a relative humidity of 90% to prepare a hydrotrope composite, and then dried at 50 ° C. for 3 hours under reduced pressure to prepare a composite powder for improving hair loss.

Furtherance (content, wt%)	iso Niacinamide	adenosine	HP-b-CD	b-CD	EDTA-2Na
Example 1	60	30	10	0	0
Example 2	57.5	30	9	3.5	0
Example 3	44	30	15	10	One
Example 4	30	30	15	24	One
Example 5	54	30	5	10	One
Comparative Example 1	20	30	10	39	One
Comparative Example 2	10	30	0	59	One
Comparative Example 3	0	30	0	69	One
Comparative Example 4	0	30	69	0	One
Comparative Example 5	0	30	35	34	One

[Comparative Example 6]

In the composition ratio of Example 1, each raw material was put into a double cone mixer and dry blended at room temperature (25 ° C.) at 10 rpm for 2 hours to prepare a composite powder for improving hair loss.

Dissolution rate evaluation

2.5 g of the composite powder for improving hair loss prepared in Examples 1 to 5 and Comparative Examples 1 to 7 was added to 100 g of distilled water at room temperature (25 ° C), stirred at 500 rpm to observe the complete dissolution rate, and the following evaluation The results evaluated based on the criteria are listed in Table 2 below.

◎: completely dissolved within 150 seconds

○: completely dissolved within 150 seconds to 5 minutes

△: completely dissolved within 5 to 10 minutes

X: It takes more than 10 minutes to completely dissolve

	Example 1	Example 2	Example 3	Example 4	Example 5
dissolution rate	○	◎	◎	◎	◎
	Comparative Example 1	Comparative Example 2	Comparative Example 3	Comparative Example 4	Comparative Example 5	Comparative Example 6
dissolution rate	△	X	X	△	△	X

Solubility evaluation

1) Evaluation of solubility in distilled water

After completely dissolving 0.25 g of the composite powder for improving hair loss prepared in Examples 1 to 5 and Comparative Examples 1 to 6 in 10 g of distilled water, 4 ℃, 25 ℃, 50 ℃, cycle (-18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ Maintained for 24 hours at each temperature, 1 hour required when changing the temperature condition) for 4 weeks to observe whether precipitation occurred, and the results evaluated according to the following evaluation criteria are listed in Table 3 below did

1A: Precipitation occurs after 1 week of storage

2A: Precipitation occurs after 2 weeks of storage

3A: Precipitation occurs after 3 weeks of storage

4A: Precipitation occurs after 4 weeks of storage

-: No precipitation

	4℃	25℃	50 ℃	cycle
Example 1	-	-	-	-
Example 2	-	-	-	-
Example 3	-	-	-	-
Example 4	-	-	-	-
Example 5	-	-	-	-
Comparative Example 1	2A	3A	-	2A
Comparative Example 2	1A	3A	4A	1A
Comparative Example 3	1A	2A	4A	1A
Comparative Example 4	2A	3A	4A	1A
Comparative Example 5	1A	2A	4A	2A
Comparative Example 6	4A	-	-	4A

2) Solubility evaluation for skin toner and shampoo

After dissolving 0.25 g of the complex powder for improving hair loss prepared in Examples 1 to 5 and Comparative Examples 1 to 6 in 10 g of skin toner and shampoo, respectively, 4 ℃, 25 ℃, 50 ℃, cycle (-18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ Maintained for 24 hours at each temperature, it takes 1 hour to change the temperature condition) for 4 weeks to observe whether precipitation occurs, and the results evaluated according to the following evaluation criteria are shown in the table below 4. Formulations of the skin toner and shampoo used in the evaluation are shown in FIGS. 1 and 2, respectively.

1A: Precipitation occurs after 1 week of storage

2A: Precipitation occurs after 2 weeks of storage

3A: Precipitation occurs after 3 weeks of storage

4A: Precipitation occurs after 4 weeks of storage

-: No precipitation

	4℃		25℃		50 ℃		cycle
	toner	shampoo	toner	shampoo	toner	shampoo	toner	shampoo
Example 1	-	-	-	-	-	-	-	-
Example 2	-	-	-	-	-	-	-	-
Example 3	-	-	-	-	-	-	-	-
Example 4	-	-		-	-	-	-	-
Example 5	-	-	-	-	-	-	-	-
Comparative Example 1	2A	2A	3A	3A	-	-	2A	2A
Comparative Example 2	1A	1A	3A	3A	4A	4A	1A	1A
Comparative Example 3	1A	1A	2A	2A	4A	4A	1A	1A
Comparative Example 4	2A	2A	3A	3A	4A	4A	1A	1A
Comparative Example 5	1A	1A	2A	2A	4A	4A	2A	2A
Comparative Example 6	4A	4A	-	-	-	-	4A	4A

It was confirmed that the complex powder for improving hair loss according to the present invention was remarkably excellent in both dissolution rate and solubility. Specifically, as shown in Table 2, the composite powders for improving hair loss of Examples 1 to 5 had a very good dissolution rate in distilled water and were completely dissolved (2.5 wt%) within 150 seconds. On the other hand, the complex powders for improving hair loss of Comparative Examples 1 to 6 took 5 or 10 minutes or more to completely dissolve.

In addition, as shown in Tables 3 and 4, the composite powders for improving hair loss of Examples 1 to 5 had excellent solubility in distilled water as well as skin toner and shampoo, and were thus treated at 4 ° C, 25 ° C, 50 ° C, cycle (- 18 ℃ -> 25 ℃ -> 40 ℃ -> 25 ℃ -> -18 ℃ Maintained for 24 hours at each temperature, 1 hour required for changing temperature conditions) Even when stored for 4 weeks, no precipitation occurred. On the other hand, in Comparative Examples 1 to 6, it was found that precipitation occurred even under high temperature (50 °C) conditions, resulting in significantly reduced product stability.

That is, the complex powder for improving hair loss according to the present invention can be easily used by dissolving in a shampoo used every day in daily life, and thus not only has excellent usability, but also can exhibit an excellent hair loss improvement effect by including a high content of adenosine. In addition, the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.

Claims (13)

1. A complex powder for hair loss improvement containing adenosine, niacinamide and cyclodextrin,

   10 to 50% by weight of adenosine, 25 to 70% by weight of niacinamide, and 5 to 45% by weight of cyclodextrin, based on the total weight of the complex powder for improving hair loss, and the complex powder for improving hair loss is added to 100 g of an aqueous solvent at 25 ° C. A complex powder for improving hair loss having a dissolution rate of 1 mg/sec or more when dissolving 2.5 g.
2. According to claim 1,

   Complex powder for improving hair loss comprising the adenosine and niacinamide in a weight ratio of 1:1 to 1:3.
3. According to claim 1,

   The niacinamide is isoniacinamide, complex powder for improving hair loss.
4. According to claim 1,

   The cyclodextrin is a complex powder for improving hair loss comprising beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
5. According to claim 1,

   The water-based solvent is a composite powder for improving hair loss containing distilled water.
6. According to claim 1,

   A complex powder for improving hair loss, further comprising ethylenediaminetetraacetic acid sodum salt (Disodium EDTA).
7. A cosmetic composition for hair comprising the complex powder for improving hair loss according to any one of claims 1 to 6.
8. According to claim 7,

   The cosmetic composition for hair includes shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack and hair cream.
9. According to claim 7,

   A cosmetic composition for hair comprising 0.1 to 5% by weight of adenosine based on the total weight of the cosmetic composition for hair.
10. (a) preparing a hydrotrope complex by introducing adenosine, niacinamide and cyclodextrin into a powder mixer and uniformly mixing them under humid conditions; and

    (b) drying the hydrotrope complex; comprising a method for producing a complex powder for improving hair loss.
11. According to claim 10,

    The powder mixer in step (a) is a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer or a coulter mixer, a method for producing a composite powder for improving hair loss.
12. According to claim 10,

    The humidification conditions in step (a) are 80 to 95% relative humidity, a method for producing a composite powder for improving hair loss.
13. According to claim 10,

    The hydrotrope complex of step (a) is an aggregate in which adenosine, niacinamide and cyclodextrin are aggregated, a method for producing a complex powder for improving hair loss.

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