WO2022239914A1 - Poudre composite destinée à atténuer la perte de cheveux et composition cosmétique capillaire la contenant - Google Patents

Poudre composite destinée à atténuer la perte de cheveux et composition cosmétique capillaire la contenant Download PDF

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Publication number
WO2022239914A1
WO2022239914A1 PCT/KR2021/013565 KR2021013565W WO2022239914A1 WO 2022239914 A1 WO2022239914 A1 WO 2022239914A1 KR 2021013565 W KR2021013565 W KR 2021013565W WO 2022239914 A1 WO2022239914 A1 WO 2022239914A1
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Prior art keywords
hair loss
hair
powder
adenosine
complex
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PCT/KR2021/013565
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English (en)
Korean (ko)
Inventor
한영희
소희진
정철
신찬재
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(주)바이오제닉스
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Publication of WO2022239914A1 publication Critical patent/WO2022239914A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a complex powder for improving hair loss and a cosmetic composition for hair comprising the same.
  • Hair loss refers to a condition in which there is little or no hair in the area where hair should normally exist.
  • the causes of hair loss include genetic causes, the action of male hormones, as well as severe causes such as endocrine diseases, nutritional deficiencies, drug use, childbirth, fever, and surgery. It is known that factors such as physical and mental stress are complexly involved to show hair loss symptoms. In recent years, not only male pattern baldness but also female hair loss is on the rise, and the number of people suffering from abnormal scalp and hair symptoms is increasing and their age is also getting lower.
  • adenosine has excellent stability and anti-wrinkle effect on the human body, as well as excellent safety on the human body when penetrating into the skin, proving the hair loss improvement and hair growth effect of adenosine, a substance notified as a raw material for wrinkle improvement.
  • adenosine has a very low water solubility, recrystallization or precipitation occurs in cosmetic compositions or pharmaceutical compositions, and it is difficult to contain adenosine at high concentrations. Therefore, it is inevitable to be included in a low content of less than the effective concentration in the composition, and there is a limit to implementing a satisfactory effect.
  • the present invention has been made to solve the above problems, and an object of the present invention is to provide a complex powder for improving hair loss that can be easily used by rapidly dissolving a high content of adenosine.
  • the present invention provides a cosmetic composition for hair comprising the complex powder for improving hair loss.
  • the present invention is a complex powder for improving hair loss containing adenosine, niacinamide and cyclodextrin, comprising 10 to 50% by weight of adenosine and 25 to 70% by weight of niacinamide, based on the total weight of the complex powder for improving hair loss.
  • adenosine powder for improving hair loss has a dissolution rate of 1 mg/sec or more when 2.5 g is dissolved in 100 g of an aqueous solvent at 25 ° C., providing a complex powder for improving hair loss .
  • the adenosine and niacinamide may be included in a weight ratio of 1:1 to 1:3.
  • the niacinamide according to an embodiment of the present invention may be isoniacinamide.
  • the cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
  • the aqueous solvent according to an embodiment of the present invention may include distilled water.
  • the complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodum salt (Disodium EDTA).
  • ethylenediaminetetraacetic acid sodum salt Diisodium EDTA
  • the present invention provides a cosmetic composition for hair comprising the complex powder for improving hair loss.
  • the cosmetic composition for hair may include shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack, and hair cream.
  • Adenosine may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition for hair according to an embodiment of the present invention.
  • the present invention comprises the steps of (a) preparing a hydrotrope complex by introducing adenosine, niacinamide and cyclodextrin into a powder mixer and uniformly mixing them under humid conditions; And (b) drying the hydrotrope complex; it provides a method for producing a complex powder for improving hair loss, including.
  • the powder mixer of step (a) may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer, or a coulter mixer.
  • the humidification condition of step (a) may be 80 to 95% relative humidity.
  • the hydrotrope complex of step (a) may be an aggregate in which adenosine, niacinamide, and cyclodextrin are aggregated.
  • the complex powder for improving hair loss according to the present invention can implement excellent solubility and dissolution rate in water as well as cosmetic compositions for hair such as shampoo.
  • the complex powder for improving hair loss according to the present invention is rapidly dissolved in a shampoo used every day in daily life and has excellent usability, and can exhibit an excellent hair loss improvement effect by including a high content of adenosine.
  • the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization of adenosine even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.
  • Figure 1 shows the formulation of the skin toner used for solubility evaluation.
  • Figure 2 shows the formulation of the shampoo used for solubility evaluation.
  • Units used herein without special mention are based on weight, and as an example, the unit of % or ratio means weight% or weight ratio, and unless otherwise defined, weight% means that any one component of the entire composition is included in the composition. It means the weight percent occupied by
  • niacinamide means 1,3-niacinamide or 1,4-niacinamide (isoniacinamide).
  • the complex powder for improving hair loss according to the present invention may include adenosine, niacinamide and cyclodextrin.
  • adenosine Although it has been proven that adenosine has an excellent effect on improving and treating hair loss, recrystallization or precipitation occurs due to the very low solubility of adenosine, and it is difficult to contain a high concentration of adenosine. Therefore, it is inevitable to be included in a low content less than the effective concentration in the product, and there is a limit to implementing a satisfactory effect.
  • the complex powder for improving hair loss according to the present invention is one in which the solubility and dissolution rate of adenosine are significantly improved, and a cosmetic composition for hair excellent in both stability and hair loss improving effect can be provided using this.
  • the complex powder for improving hair loss may contain 10 to 50% by weight of adenosine, 25 to 70% by weight of niacinamide, and 5 to 45% by weight of cyclodextrin, based on the total weight.
  • the adenosine powder for improving hair loss may have a dissolution rate of 1 mg/sec or more when dissolving 2.5 g in 100 g of an aqueous solvent at 25 ° C., specifically, 5 mg/sec or more, or 10 mg/sec or more, It may be, without limitation, 100 mg/sec or less, 50 mg/sec or less, or 20 mg/sec or less.
  • the adenosine according to an embodiment of the present invention may be included in 10 to 40% by weight, more preferably 20 to 35% by weight based on the total weight of the complex powder for improving hair loss.
  • VEGF vascular endothelial growth factor
  • FGF-7 fibroblast growth factor-7
  • hair growth It has an excellent effect in helping to thicken the diameter (thickness) of the hair.
  • VEGF is an important growth factor that affects hair growth by helping active material exchange between capillaries and peripheral nerve cells in the scalp. It can increase the thickness and distribution of hair by increasing the size and distribution of capillaries in hair follicles and strengthen hair follicles. . That is, by promoting the expression of VEFG, it is possible to improve hair loss by forming new blood vessels around hair follicles and promoting blood circulation.
  • FGF-7 is a fibroblast growth factor, which is involved in promoting hair follicle cell differentiation to maintain hair follicles in the growing phase and stimulates hair growth to help improve hair loss.
  • the niacinamide according to an embodiment of the present invention may be included in 25 to 70% by weight, preferably 30 to 70% by weight, more preferably 30 to 60% by weight, based on the total weight of the complex powder for improving hair loss.
  • the complex powder for improving hair loss according to an embodiment of the present invention may include the adenosine and niacinamide in a weight ratio of 1:1 to 1:3, and especially containing the adenosine and niacinamide in a weight ratio of 1:1 to 1:2.5 desirable.
  • the complex powder for improving hair loss includes niacinamide in the above numerical range, thereby improving the solubility of adenosine and at the same time providing a synergistic effect with adenosine in the effect of improving hair loss.
  • niacinamide (nicotinamide, nicotinamide, nicotamide) is a generic term for nicotinic acid and nicotinic acid amide, belongs to the vitamin B group, supplies nutrients to the scalp and hair, and prevents oxidation of components. It helps to maintain product stability.
  • niacinamide since niacinamide has a hydrotropic property, it can significantly improve the solubility of adenosine by interacting with adenosine and make it possible to contain adenosine in a high concentration in a product.
  • the niacinamide according to an embodiment of the present invention may be isoniacinamide in terms of improving the solubility and dissolution rate of adenosine.
  • the complex powder for improving hair loss according to the present invention may be advantageous in forming an effective hydrotrope complex with adenosine, and thus, the solubility and dissolution rate of adenosine may be further improved.
  • the cyclodextrin according to an embodiment of the present invention may be included in an amount of 5 to 45% by weight, preferably 10 to 45% by weight, more preferably 20 to 40% by weight, based on the total weight of the complex powder for improving hair loss. can be included as
  • the cyclodextrin according to an embodiment of the present invention may include beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
  • the complex powder for improving hair loss contains cyclodextrin in the above numerical range, thereby realizing a synergistic effect with niacinamide to improve the solubility of adenosine, as well as product stability and hair loss improvement effect can be enhanced at the same time.
  • the complex powder for improving hair loss according to the present invention can significantly improve the dissolution rate by forming a hydrotrope complex of adenosine, niacinamide and cyclodextrin, and can prevent precipitation or recrystallization of adenosine during long-term storage. .
  • the complex powder for improving hair loss according to an embodiment of the present invention may further include ethylenediaminetetraacetic acid sodum salt (Disodium EDTA, EDTA 2Na) as a stabilizer.
  • ethylenediaminetetraacetic acid sodum salt Disodium EDTA, EDTA 2Na
  • the complex powder for improving hair loss according to the present invention has the above-described structural characteristics, so that the solubility and dissolution rate of adenosine can be remarkably improved.
  • the solubility of adenosine in water at room temperature (25 ° C.) has been known to be 0.26% by weight, but the solubility of adenosine in water at room temperature (25 ° C.) in the complex powder for improving hair loss according to the present invention is 1% by weight. up to, and no precipitation or recrystallization occurs.
  • the complex powder for improving hair loss has very high solubility in hair cosmetic compositions such as shampoo, treatment, hair tonic, hair mist, hair essence, hair tonic, hair pack, and hair cream as well as water. great.
  • the cosmetic composition for hair may include 0.1 to 5% by weight of adenosine, preferably 0.5 to 3% by weight, more preferably 0.5 to 2% by weight based on the total weight of the composition.
  • the complex powder for improving hair loss according to the present invention can be easily used by dissolving in a shampoo used every day in daily life, and thus not only has excellent usability, but can also contain a high content of adenosine, thereby exhibiting an excellent hair loss improvement effect.
  • the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.
  • the present invention comprises the steps of (a) preparing a hydrotrope complex by introducing adenosine, niacinamide and cyclodextrin into a powder mixer and uniformly mixing them under humid conditions; and (b) drying the hydrotrope complex.
  • the step (a) is a step of uniformly mixing the raw materials before humidifying conditions, and may include mixing the raw materials in a powder mixer and mixing them evenly at room temperature (25 ° C.) for 30 minutes to 2 hours.
  • the powder mixer is not particularly limited as long as it is a powder mixer commonly used in the art, but as a non-limiting example, it may be a double cone mixer, a paddle mixer, a V-type mixer, a cone mixer, or a coulter type mixer, and a double cone mixer it is more preferable
  • the humidification conditions of the step (a) according to an embodiment of the present invention may be performed at a relative humidity of 80 to 95%, more specifically, at 85 to 95%, and at room temperature (25 ° C.) for 1 hour to 3 hours
  • a hydrotrope complex can be formed by uniformly blending.
  • the hydrotrope complex prepared in step (a) may be an aggregate in which adenosine, niacinamide, and cyclodextrin are aggregated.
  • the complex powder for improving hair loss according to an embodiment of the present invention can significantly improve the solubility and dissolution rate of adenosine by forming a hydrotrope complex through the step (a).
  • the drying method of the step (b) according to an embodiment of the present invention is not particularly limited, and a known method such as blow drying or reduced pressure drying may be used, and it is more preferable to use reduced pressure drying.
  • the drying temperature may be 30 to 150 °C, preferably 40 to 120 °C, and more preferably 50 to 100 °C.
  • the drying time is not particularly limited, but the complex powder for improving hair loss can be sufficiently dried by performing the drying for 2 to 5 hours.
  • each raw material was put into a double cone mixer and mixed at 10 rpm for 120 minutes at room temperature (25 ° C.). Thereafter, steam was sprayed and mixed at 10 rpm for 2 hours under a relative humidity of 90% to prepare a hydrotrope composite, and then dried at 50 ° C. for 3 hours under reduced pressure to prepare a composite powder for improving hair loss.
  • each raw material was put into a double cone mixer and dry blended at room temperature (25 ° C.) at 10 rpm for 2 hours to prepare a composite powder for improving hair loss.
  • Example 1 Example 2 Example 3 Example 4 Example 5 dissolution rate ⁇ ⁇ ⁇ ⁇ ⁇ Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 dissolution rate ⁇ X X ⁇ ⁇ X
  • the complex powder for improving hair loss according to the present invention was remarkably excellent in both dissolution rate and solubility. Specifically, as shown in Table 2, the composite powders for improving hair loss of Examples 1 to 5 had a very good dissolution rate in distilled water and were completely dissolved (2.5 wt%) within 150 seconds. On the other hand, the complex powders for improving hair loss of Comparative Examples 1 to 6 took 5 or 10 minutes or more to completely dissolve.
  • the composite powders for improving hair loss of Examples 1 to 5 had excellent solubility in distilled water as well as skin toner and shampoo, and were thus treated at 4 ° C, 25 ° C, 50 ° C, cycle (- 18 °C -> 25 °C -> 40 °C -> 25 °C -> -18 °C Maintained for 24 hours at each temperature, 1 hour required for changing temperature conditions) Even when stored for 4 weeks, no precipitation occurred.
  • Comparative Examples 1 to 6 it was found that precipitation occurred even under high temperature (50 °C) conditions, resulting in significantly reduced product stability.
  • the complex powder for improving hair loss according to the present invention can be easily used by dissolving in a shampoo used every day in daily life, and thus not only has excellent usability, but also can exhibit an excellent hair loss improvement effect by including a high content of adenosine.
  • the cosmetic composition for hair in which the complex powder for improving hair loss according to the present invention is dissolved can maintain excellent stability without precipitation or recrystallization even during long-term storage. That is, the complex powder for improving hair loss according to the present invention can satisfy all of excellent hair loss improvement effects, excellent stability, market competitiveness and usability.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
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  • Molecular Biology (AREA)

Abstract

La présente invention se rapporte à une poudre composite, comprenant de l'adénosine, du niacinamide et de la cyclodextrine, destinée à atténuer la perte de cheveux. En particulier, la poudre composite destinée à atténuer la perte de cheveux comprend de 10 à 50 % en poids d'adénosine, de 25 à 70 % en poids de niacinamide, et de 5 à 45 % en poids de cyclodextrine par rapport au poids total de cette dernière, et la poudre d'adénosine destinée à atténuer la perte de cheveux peut avoir un taux de dissolution de 1 mg/sec ou plus lorsque 2,5 g de cette dernière sont dissous à 25 °C dans 100 g d'un solvant aqueux.
PCT/KR2021/013565 2021-05-13 2021-10-05 Poudre composite destinée à atténuer la perte de cheveux et composition cosmétique capillaire la contenant WO2022239914A1 (fr)

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Application Number Priority Date Filing Date Title
KR1020210061995A KR102337124B1 (ko) 2021-05-13 2021-05-13 탈모 개선용 복합 파우더 및 이를 포함하는 모발용 화장료 조성물
KR10-2021-0061995 2021-05-13

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116421491A (zh) * 2023-05-30 2023-07-14 广州市名嫡化妆品有限公司 腺苷水性组合物、腺苷溶液及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0175934B1 (ko) * 1990-03-27 1999-03-20 치에시 파올로 피록시캄/사이클로덱스트린 복합체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
WO2008088816A1 (fr) * 2007-01-18 2008-07-24 Pgxhealth, Llc Formulations de dérivé d'adénosine pour l'imagerie médicale
US20140107059A1 (en) * 2012-10-12 2014-04-17 L'oreal S.A. Compositions containing adenosine or an adenosine analogue and hydrotropes for cosmetic use
KR20150092102A (ko) * 2012-10-12 2015-08-12 로레알 적어도 하나의 하이드로트로프 및 적어도 하나의 활성제을 포함하는 화장용 조성물
US20190159989A1 (en) * 2017-11-30 2019-05-30 L'oreal Aqueous compositions with mangiferin for cosmetic applications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0175934B1 (ko) * 1990-03-27 1999-03-20 치에시 파올로 피록시캄/사이클로덱스트린 복합체, 이의 제조방법 및 이를 포함하는 약제학적 조성물
WO2008088816A1 (fr) * 2007-01-18 2008-07-24 Pgxhealth, Llc Formulations de dérivé d'adénosine pour l'imagerie médicale
US20140107059A1 (en) * 2012-10-12 2014-04-17 L'oreal S.A. Compositions containing adenosine or an adenosine analogue and hydrotropes for cosmetic use
KR20150092102A (ko) * 2012-10-12 2015-08-12 로레알 적어도 하나의 하이드로트로프 및 적어도 하나의 활성제을 포함하는 화장용 조성물
US20190159989A1 (en) * 2017-11-30 2019-05-30 L'oreal Aqueous compositions with mangiferin for cosmetic applications

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116421491A (zh) * 2023-05-30 2023-07-14 广州市名嫡化妆品有限公司 腺苷水性组合物、腺苷溶液及其制备方法和应用
CN116421491B (zh) * 2023-05-30 2023-11-10 广州市名嫡化妆品有限公司 腺苷水性组合物、腺苷溶液及其制备方法和应用

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