CN113398003A

CN113398003A - Skin repairing special cream and preparation method thereof

Info

Publication number: CN113398003A
Application number: CN202110745742.7A
Authority: CN
Inventors: 钱进; 向琼彪; 李华真; 李传茂; 林盛杰; 张伟杰; 曾伟丹; 张楚标
Original assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Current assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Priority date: 2021-07-01
Filing date: 2021-07-01
Publication date: 2021-09-17
Also published as: CN115040434A

Abstract

The invention provides a special skin-repairing cream and a preparation method thereof. The skin repair special cream comprises the following components: anti-inflammatory repair component: 0.13% -13%; moisture retention component: 1.02% -11.2%; and a barrier repair component: 0.11% -6%; wherein the moisturizing component comprises a polyol, hyaluronic acid or a salt thereof, and a ceramide. The skin repair special cream disclosed by the invention is excellent in repairing skin barriers, controlling skin inflammation and moisturizing, and is light and thin in skin feel. The preparation method of the skin-repairing special cream is simple and easy to implement, the raw materials are easy to obtain, and the skin-repairing special cream is suitable for mass production.

Description

Skin repairing special cream and preparation method thereof

Technical Field

The invention relates to a special skin-repairing cream and a preparation method thereof, belonging to the field of cosmetics.

Background

The number of people with sensitive muscles is gradually increasing due to environmental pollution, stress, cosmetic abuse, and the like. In some of these people, the water-oil balance of the epidermis is destroyed because the skin barrier is damaged, and the appearance is obviously that the horny layer is thin and the skin is dry, but the oil is loved. These people often use moisturizing masks, but the skin barrier is compromised and the water retention is poor. The pores are blocked due to frequent oil production, and the phenomenon of large pores appears. For the people, the compound moisturizing and relieving effects should be mainly achieved by repairing.

Citation 1 discloses an anti-inflammatory and bacteriostatic composition, which comprises honeysuckle, phellodendron, sophora flavescens, spirulina, inulin, alpha-glucose oligosaccharide, sodium carboxymethylcellulose, menthol, propylene glycol and the like. The formulation can control skin inflammation by regulating skin microecology to repair skin barrier. But not only anti-inflammatory and bacteriostatic are needed for sensitive muscle care. Therefore, on this basis, products have emerged that combine the enhancement of skin collagen with the regulation of skin microecology.

Citation 2 discloses a bionic composition for repairing skin barriers and a preparation method thereof, wherein the composition comprises 7.5-10% of a humectant, 7-10% of an emollient, 0.4-0.5% of a thickening agent, 2.5-4.5% of a liquid crystal bionic emulsifier and 11-18% of a skin barrier repairing agent, and the skin barrier is comprehensively repaired from five dimensions of supplementing a sebum membrane, repairing a brick wall structure, regulating expression of aquaporins, supplementing natural moisturizing factors, inhibiting inflammation, strengthening an immune system, promoting proliferation of fibroblasts in a dermis layer and protecting collagen and a matrix. However, the formula focuses on postoperative skin barrier repair, and the moisturizing effect in a short period of time is not very obvious.

In view of the above, research on a skin repair cream for repairing skin barrier, controlling skin inflammation, and moisturizing is an urgent technical problem to be solved.

Disclosure of Invention

Problems to be solved by the invention

In view of the technical problems in the prior art, for example: the invention provides a special skin-repairing cream, which has excellent effects of repairing a skin barrier, controlling skin inflammation and moisturizing.

Furthermore, the invention also provides a preparation method of the skin-repairing special cream, which is simple and feasible, has easily obtained raw materials and is suitable for mass production.

Means for solving the problems

The invention provides a special skin-repairing cream which comprises the following components:

anti-inflammatory repair component: 0.13% -13%;

moisture retention component: 1.02% -11.2%; and

barrier repair component: 0.11% -6%; wherein

The moisturizing component comprises a polyol, hyaluronic acid or a salt thereof, and a ceramide.

The skin-repairing special cream comprises a moisturizing component and a skin-repairing special cream base, wherein the moisturizing component is added in an amount of 1% -10% by total mass of the skin-repairing special cream base; the addition amount of the ceramide is 0.01-1%; the addition amount of the hyaluronic acid or the salt thereof is 0.01-0.3%.

The skin-repairing special cream comprises one or more of madecassoside, polypeptide, patchouli leaf extract and salvia miltiorrhiza extract;

preferably, the content of the madecassoside is 0.01-1% of the total mass of the skin-repairing special cream; the content of the polypeptide is 0.01-5%; the content of the patchouli leaf extract is 0.01-2%; the content of the salvia miltiorrhiza extract is 0.1-5%.

The skin repair cream according to the present invention, wherein the polypeptide comprises oligopeptide-1 and/or palmitoyl tetrapeptide-7.

The skin rejuvenation cream according to the invention, wherein the barrier repair component comprises ceramides and/or phytosterol canola glycerides;

preferably, the content of the ceramide is 0.01-1% by the total mass of the skin repair special cream; the content of the phytosterol low erucic acid rapeseed oil glyceride is 0.1-5%.

The skin repairing special cream further comprises one or the combination of more than two of an emulsifier, skin moistening grease, a thickener and a preservative;

preferably, the content of the emulsifier is 0.1-1%; the content of the emollient oil is 1% -10%, the content of the thickening agent is 0.3% -1%, and the content of the preservative is 0.1% -1%.

The skin repair cream comprises one or more of lecithin, PEG-20 methyl glucose sesquistearate and methyl glucose sesquistearate. .

The skin repair cream comprises one or more of carbomer, acryloyl dimethyl taurate/VP copolymer and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.

The skin repair cream comprises one or more of polydimethylsiloxane, shea butter, caprylic/capric triglyceride, dimethiconol and squalane.

The invention also provides a preparation method of the skin-repairing special cream, which comprises the step of mixing the components of the skin-repairing special cream.

ADVANTAGEOUS EFFECTS OF INVENTION

The skin repair special cream disclosed by the invention is excellent in repairing skin barriers, controlling skin inflammation and moisturizing, and is light and thin in skin feel.

The preparation method of the skin-repairing special cream is simple and easy to implement, the raw materials are easy to obtain, and the skin-repairing special cream is suitable for mass production.

Detailed Description

Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.

All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.

In the present specification, "%" denotes mass% unless otherwise specified.

In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.

In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.

In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.

In the present specification, the term "water" includes any available water that can be used in the cosmetic field, such as deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.

In the present specification, if "room temperature", "normal temperature" or the like appears, the meaning may be 10 to 40 ℃.

A first aspect of the invention provides a skin rejuvenation benefit cream comprising the following components:

anti-inflammatory repair component: 0.13% -13%;

moisture retention component: 1.02% -11.2%; and

barrier repair component: 0.11% -6%; wherein

Moisturizing component

The moisturizing component of the present invention comprises a polyol, hyaluronic acid or a salt thereof, and a ceramide. The moisturizing component can effectively improve the moisture content of the epidermis of the skin, can achieve deep moisturizing from the essence, and has excellent moisturizing effect when being applied to the skin repairing special cream.

The polyols of the present invention are relatively low molecular weight polyols. The polyhydric alcohol can not only form a layer of compact protective film on the surface of the skin to reduce the loss of moisture, but also promote the skin repair special cream to absorb the moisture from the environment, supplement the moisture to the skin and increase the water content of the surface of the skin.

Further, in the present invention, the polyol includes: one or more of glycerol, 1, 4-butanediol, pentanediol, 1, 2-propanediol, 1, 3-propanediol, dipropylene glycol and methyl propanediol. Preferably, glycerin and/or pentanediol can be used as the polyhydric alcohol in the present invention, and when glycerin is used, the effect of the skin-care cream of the present invention can be exerted to the maximum extent, and the water content of the skin surface can be effectively increased. When the pentanediol is used, the preservative synergistic effect can be achieved while moisture is preserved. According to the invention, when glycerin and pentanediol are preferably used as the polyhydric alcohols, the skin repair special cream disclosed by the invention can exert the effect to the maximum extent, effectively increase the water content of the skin surface and play a role in antisepsis and synergism.

Further, in the present invention, when the content of the polyol is too low, the effect of increasing the water content of the skin surface cannot be exerted, and when the content of the polyol is too high, the effect of increasing the water content of the skin surface is caused to be too low, which affects the skin feel and the cost of the product. Specifically, the polyol is present in an amount of 1% to 10%, preferably 2% to 5%, such as 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc., based on the total mass of the skin rejuvenating benefit cream.

Hyaluronic acid, also known as hyaluronic acid, is an acidic mucopolysaccharide. It is an important basic substance for skin tenderness, is a component of human body, has a special water-retaining action, has a weight which is 100 times higher than that of the skin tenderness, is a substance which is found to have the best moisture-retaining property in nature at present, and is called as an ideal natural moisture-retaining factor. It can improve skin nutrition metabolism, make skin tender and smooth, remove wrinkle, increase elasticity, and prevent aging, and is good transdermal absorption promoter while keeping moisture. The nutrient can be used together with other nutrient components to achieve the more ideal effect of promoting nutrient absorption.

In the invention, the hyaluronic acid or the salt thereof can be sodium hyaluronate with large molecular weight or small molecular weight; specifically, the weight average molecular weight of the hyaluronic acid or the salt thereof is less than 180 kilodaltons, and preferably, the weight average molecular weight of the high molecular weight sodium hyaluronate is 100 kilodaltons to 180 kilodaltons, and the weight average molecular weight of the low molecular weight sodium hyaluronate is 5 kilodaltons to 1 kilodaltons.

Generally, the hyaluronic acid salt is usually used in the form of its SODIUM salt, i.e. SODIUM HYALURONATE (SH). The sodium hyaluronate is extracted from rooster comb, or prepared by fermentation of lactococcus lactis, and is white or white-like granule or powder, and has no odor, nitrogen content of 2.8-4.0% and glucuronic acid content of 37.0-51.0% when dried.

However, hyaluronic acid or its salt has a large molecular structure, and is likely to aggregate after being applied to the skin; in addition, hyaluronic acid or its salt has many hydroxyl groups, and adhesion to the skin surface is mainly due to the hydrogen bonding force of the hydroxyl groups, but when the hydroxyl groups do not absorb moisture to the outside, the moisture content of the epidermis cannot be increased. The inventors of the present invention have found that the function of hyaluronic acid or a salt thereof can be further promoted in the presence of a polyhydric alcohol and a ceramide, and that moisture can penetrate into the epidermis of the skin, whereby the moisture content of the epidermis of the skin can be effectively increased, and deep moisturizing can be achieved essentially.

Further, in the present invention, when the content of hyaluronic acid or a salt thereof is too low, the moisture content of the skin epidermis cannot be increased; when the content of hyaluronic acid or a salt thereof is too high, excessive consistency is caused, which is unfavorable for skin absorption. Specifically, the hyaluronic acid or a salt thereof is added in an amount of 0.01% to 0.3%, preferably 0.05% to 0.3%, for example, 0.02%, 0.03%, 0.04%, 0.06%, 0.07%, 0.08%, 0.19%, 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, etc., based on the total mass of the skin-rejuvenating cream.

In the present invention, ceramide is also called glycolipid, phytosphingosine. The ceramide is prepared by screening high-yield strains from candida, converting the strains into the ceramide by using olive oil nutrient substances in the growth and metabolism processes of thalli by adjusting the growth and fermentation conditions of the yeasts and providing certain nutrient substances, is easy to permeate into the intercellular spaces of the horny layer of the skin, maintains the moisture of the skin, and has the effects of moisturizing, moistening the skin and repairing the skin barrier.

The ceramide of the invention is formed by the sugar linkage of fatty acid, mannose and erythrose. The unique structure makes it easy to penetrate into the corneocytes and fuse with the original outer cytoplasm to form a liquid crystal layer. Can be used for keeping moisture and keeping skin moisture. The ceramide has lipophilic and hydrophilic groups, is an amphiphilic molecule, and is helpful for spreading hyaluronic acid on the surface of skin to achieve the effect of moisturizing if being combined with sodium hyaluronate.

The inventors of the present invention have found that the moisturizing function of polyhydric alcohol and hyaluronic acid or a salt thereof can be further promoted in the presence of a ceramide, and the water content of the skin epidermis can be effectively increased. It can promote the humectant to permeate into the horny cells, and achieve the moisturizing effect by locking the humectant.

Further, in the present invention, when the amount of the ceramide added is too low, the moisture content of the skin epidermis cannot be increased; when the amount of the ceramide added is too high, no more excellent effect is obtained, and the cost is also high. Specifically, the ceramide of the present invention is added in an amount of 0.01% to 1%, preferably 0.1% to 0.5%, for example, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc., based on the total mass of the skin-rejuvenating cream.

Anti-inflammatory repair compositions

The anti-inflammatory repair component can comprise one or the combination of more than two of madecassoside, polypeptide, patchouli leaf extract and salvia miltiorrhiza extract.

The madecassoside is white powder, has the effects of relieving itching, removing red and relieving discomfort, effectively reduces the release of proinflammatory cytokines interleukin-1 alpha and interleukin-8 alpha, relieves the occurrence of inflammatory reaction, simultaneously protects cells from being damaged by active oxygen free radicals, reduces the synthesis of matrix metalloproteinase-1 and promotes the generation of collagen I.

Specifically, the content of the madecassoside is 0.01-1% by mass of the total mass of the skin-repairing special cream, for example: 0.02%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc. When the content of the madecassoside is within the range of 0.01-1%, the madecassoside has good effects of diminishing inflammation, removing redness and relieving discomfort.

Polypeptides are compounds in which alpha-amino acids are linked together by peptide bonds, and are also intermediates in the hydrolysis of proteins. The compounds obtained by dehydration condensation of two amino acid molecules are called dipeptides, and similarly, tripeptides, tetrapeptides, pentapeptides, and the like are also included. Generally, a compound obtained by dehydrating and condensing three or more amino acid molecules may be called a polypeptide. The anti-inflammatory repair efficacy of the skin repair cream is further improved by using the polypeptide.

Specifically, the content of the polypeptide is 0.01% -5% by total mass of the skin repair special cream, such as: 0.1%, 0.3%, 0.5%, 0.8%, 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. When the content of the polypeptide is within the range of 0.01-5%, the polypeptide has good bactericidal effect, so that the anti-inflammatory repair effect is improved.

In some specific embodiments, the polypeptides of the invention include oligopeptide-1 and/or palmitoyl tetrapeptide-7. Wherein Oligopeptide-1 (Oligopeptide-1) is a synthetic polypeptide consisting of glycine, histidine and lysine. It can promote the growth of injured skin tissue, has good curative effect on the healing of skin ulcer, and provides nutrition for the repair of skin. Palmitoyl Tetrapeptide-7 (Palmitoyl Tetrapeptide-7) can delay and inhibit the production of excessive interleukins, thereby inhibiting some of the unnecessary inappropriate inflammatory response and glycosylation damage.

The patchouli Leaf Extract (Octyldidecanol (and)) Pogostemon Cablin Leaf Extract contains various compounds including terpenes, flavonoids, phenylpropanoids, steroids and alkaloids, and has potential medicinal values in resisting bacteria, inflammation, allergy and immunity.

The content of the patchouli leaf extract is 0.01-2%, preferably 0.5-1% by weight of the total weight of the skin repair special cream; for example: 0.1%, 0.3%, 0.8%, 1.2%, 1.5%, 1.8%, etc. When the content of the patchouli leaf extract is 0.01-2%, an excellent anti-inflammatory effect can be achieved.

The main ingredient of Saviae Miltiorrhizae radix (Salvia Miltiorrhiza) extract is phenanthrenequinone derivative. In the culture of fibroblasts, the extract has good effect of promoting the proliferation of collagen, thereby enhancing the metabolism of the dermal layer of the skin and having the effects of resisting bacteria, resisting inflammation and the like.

Specifically, the content of the salvia miltiorrhiza bunge extract is 0.1% -5%, preferably 0.2% -2% by total mass of the skin repair special cream, such as: 0.3%, 0.5%, 0.8%, 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. When the content of the salvia miltiorrhiza bunge extract is within the range of 0.1-5%, the salvia miltiorrhiza bunge extract has good sterilizing and anti-inflammatory effects and also has the effects of activating skin and repairing.

When the combination of madecassoside, polypeptide, patchouli leaf extract and salvia miltiorrhiza extract is used as an anti-inflammatory repair component, the combination has a synergistic effect, and the efficacy of each component in the combination can be exerted most effectively.

Barrier repair compositions

The barrier repair component of the present invention may comprise ceramides and/or the phytosterol canola oil glycerides.

Among them, ceramide is a main component constituting a lipid of the stratum corneum of the skin, and helps repair the skin barrier, so that the skin is soft and glossy. Ceramide not only can resist external stimulation, but also can thicken the horny layer, improve the tolerance of the whole skin, avoid sensitivity and repair red blood filaments, and is an excellent barrier repair component.

Preferably, the ceramide is present in an amount of 0.01% to 1%, preferably 0.3 to 0.6%, for example: 0.02%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc. When the addition amount of the ceramide is 0.01-1%, the ceramide can effectively resist external stimulation, thicken the stratum corneum, improve the tolerance of the whole skin, avoid sensitivity and repair red blood streak.

The phytosterols, Canola Glycerides (AAK AB), are suitable for use in sensitive muscles to improve the water retention of dry skin and protect the skin from environmental hazards.

Preferably, the phytosterol canola glycerides are present in an amount of from 0.1% to 5%, preferably from 0.5% to 2%, by weight of the total skin rejuvenation cream, for example: 0.3%, 0.5%, 0.8%, 1.2%, 1.5%, 1.8%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, etc. When the content of the phytosterol low erucic acid rapeseed oil glyceride is 0.1-5%, the phytosterol low erucic acid rapeseed oil glyceride can better generate a synergistic effect with ceramide, so that the skin barrier is repaired.

Other Components

The skin-repairing special cream can also comprise one or the combination of more than two of emulsifier, emollient grease, thickener and preservative. Preferably, the content of the emulsifier is 0.1-1%; the content of the emollient oil is 1% -10%, the content of the thickening agent is 0.3% -1%, and the content of the preservative is 0.1% -1%.

As for the emulsifier, in the present invention, the emulsifier is added in an amount of 0.1 to 1% based on the total mass of the skin-rejuvenating super cream, for example: 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc. When the dosage of the emulsifier is too low, the emulsifier is not sufficiently emulsified, so that the system is unstable; when the dosage of the emulsifier is too high, the stability of the product can be influenced to a certain extent.

The kind of the emulsifier is not particularly limited in the present invention, and may be any emulsifier commonly used in the art. Specifically, in the present invention, the emulsifier includes one or a combination of two or more of hydrogenated lecithin, PEG-20 methylglucamine sesquistearate, and the like.

As for the thickener, in the present invention, the content of the thickener is 0.3% to 1%, preferably 0.5 to 0.8%, based on the total mass of the skin-rejuvenating cream, for example: 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, etc. The skin rejuvenation benefit cream of the present invention can be made to a suitable consistency by the addition of a thickener.

The kind of the thickener is not particularly limited in the present invention, and may be any thickener commonly used in the art. Specifically, in the invention, the thickening agent comprises one or more than two of carbomer, acryloyl dimethyl ammonium taurate/VP copolymer and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.

As for the emollient oils, in the present invention, the content of the emollient oils is 1% to 10%, preferably 2% to 5%, based on the total mass of the skin-rejuvenating special cream, for example: 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc. The skin-repairing special cream is added with skin-moistening oil, so that the evaporation of water on the surface of the skin can be reduced, and the skin is prevented from being dried and cracked. In addition, by adding emollient oils and fats, a hydrophobic film can be formed on the skin surface to prevent the invasion of harmful substances from the outside. When the content of the oil is too low, evaporation of moisture on the surface of the skin cannot be reduced, and invasion of harmful substances cannot be effectively prevented; when the content of the skin-moistening oil is too high, the skin-repairing special cream is too greasy, and the using feeling is reduced.

The type of emollient oil is not particularly limited in the present invention, and may be any thickener commonly used in the art. Specifically, in the invention, the emollient oil comprises one or more of polydimethylsiloxane, shea butter, caprylic/capric triglyceride, dimethiconol and squalane.

In addition, the skin-repairing special cream of the present invention may further contain a pH adjuster, a preservative, and the like. The content of the pH adjuster and the preservative is not particularly limited in the present invention, and may be added as needed. Specifically, the amount of the pH adjuster to be added is not particularly limited in the present invention, and the pH of the skin care cream of the present invention may be made neutral by adding the pH adjuster. While the content of the preservative cannot generally exceed the cosmetic industry regulations, in particular, the content of the preservative is 0.1% to 1%, preferably 0.5% to 0.8%.

Specifically, in the present invention, the pH adjuster may be a pH adjuster commonly used in the art, for example: aminomethyl propanol, and the like.

In a second aspect of the invention, there is provided a process for the preparation of a skin rejuvenation benefit cream comprising the step of mixing the components of the skin rejuvenation benefit cream.

Specifically, the preparation method of the skin-repairing special cream comprises the following steps:

step 1) combine the moisturizing component, optionally a thickener, and optionally deionized water as phase a, and the barrier repair component, optionally an emollient oil, and optionally an emulsifier as phase B.

Step 2) mixing the A, B phases uniformly, heating to 80-85 ℃ respectively, adding the B phase into the A phase, and homogenizing uniformly.

And 3) cooling the whole system to 45 ℃, adding the anti-inflammatory repair component, the preservative optionally existing and the pH regulator optionally existing, uniformly stirring to normal temperature, and discharging.

Examples

Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.

In the examples: the manufacturing factory of the ceramide is Guangdong modern Han prescription science and technology limited company;

the manufacturer of madecassoside is the french saibik company;

the manufacturer of the patchouli leaf extract is the company of America Asia Shilan;

the production company of the salvia miltiorrhiza extract is vast Sen Biotech limited Oriental;

the plant sterol canola oil glycerides is AKK Nordic oil group;

high molecular weight sodium hyaluronate: 100 ten thousand to 180 ten thousand daltons, manufacturer: huaxi Biotechnology Ltd;

small molecular weight sodium hyaluronate: 5-1 kilo daltons, manufacturer: huaxi Biotechnology Ltd.

Examples 1 to 7

The two phases were weighed A, B accurately.

A, B, heating to 80-85 deg.C, adding phase B into phase A, homogenizing, and cooling.

And (3) when the whole system is continuously stirred and cooled to below 45 ℃, sequentially adding the phase C and the premixed phase D, uniformly stirring and then discharging.

The skin-repairing special cream is prepared according to the method according to the mass percentage shown in the following table 1-2.

TABLE 1

TABLE 2

Comparative examples 1 to 5

The two phases were weighed A, B accurately.

Mixing A, B phases, heating to 80-85 deg.C, adding B phase into A phase, homogenizing, and cooling

The skin-repairing special cream is prepared according to the method according to the mass percentage shown in the following table 3.

TABLE 3

Performance testing

1. Soothing and repairing effect

Using examples 1 to 7 and comparative examples 1 to 4 as test samples, 20 female subjects having an allergy phenomenon at the age of 20 to 30 were selected and tested, and used daily in the morning and evening on the face in an amount of (2.0. + -. 0.1) mg/cm²(i.e., 0.0171g to 0.0189 g). The skin condition of the subjects after 7 days of use was tested in the form of questionnaires, and the soothing and repairing effect was measured in 10 points, 0 point representing no effect, and 10 points representing significant improvement in dry skin or acne symptoms, and the results are shown in tables 4 and 5.

TABLE 4

As can be seen from the results shown in Table 4, the subjects had a more significant restorative effect when the special creams prepared in examples 1 to 7 were used.

TABLE 5

Subject number	Comparative example 1	Comparative example 2	Comparative example 3	Comparative example 4	Comparative example 5
						1	2	2	2	3	6
2	3	2	2	2	5
						3	2	3	0	0	5
4	0	2	3	0	6
						5	0	3	0	2	4
6	3	0	0	0	5
						7	3	0	0	0	6
8	3	2	2	2	5
						9	0	0	0	0	4
10	0	3	0	0	6
						11	4	2	2	2	5
12	0	0	0	0	4
						13	0	0	0	0	4
14	0	0	2	2	4
						15	2	2	0	2	5
16	3	3	2	0	5
						17	3	2	0	2	3
18	0	0	0	0	6
						19	0	0	0	2	5
20	2	3	2	2	5
						Mean value of	1.5	1.45	0.85	1.05	4.9

As can be seen from the results shown in Table 5, the subjects had substantially no repairing effect when using the special creams prepared in comparative examples 1 to 4, as compared with examples 1 to 7.

2. Irritation test

Using examples 1-6 as test samples, 30 female subjects with hyperallergy at 20-30 years old were selected and tested, and used daily in the morning and evening at (2.0. + -. 0.1) mg/cm²(i.e., 0.0171g to 0.0189 g). The subjects were each tested for irritation when using the product in the form of a questionnaire, and the results are shown in table 6.

TABLE 6

Subject number	Has obvious irritation	With a little irritation/human	No irritation feeling/human
				Example 1	0	0	30
Example 2	0	0	30
				Example 3	0	0	30
Example 4	0	0	30
				Example 5	0	0	30
Example 6	0	0	30
				Example 7	0	0	30
Comparative example 1	0	0	30
				Comparative example 2	0	0	30
Comparative example 3	0	0	30
				Comparative example 4	1	4	25
Comparative example 5	0	0	30

As can be seen from the results shown in Table 6, one person felt clear stinging 4 and felt slight stinging when the special cream prepared in comparative example 4 was tried, and the test subjects felt no stinging when the special creams prepared in the remaining comparative examples were tried.

3. Test of moisturizing Effect

3.1 short term moisturization test

Female subjects of 20 to 30 years old were selected for the moisturizing test using examples 1 to 7 and comparative examples 1 to 5 as test samples. As test samples, the medial forearm area of the volunteer was 3.0cm X3.0 cm, and the amount of the sample was (2.0. + -. 0.1) mg/cm²(i.e., 0.0171g to 0.0189 g). The water content of the horny layer was measured as a value of the sample at the time of 2 hours and 4 hours after the initiation and the use of the product, respectively, and the results are shown in Table 7. Wherein the test persons numbered 1-10 performed the tests of examples 1-3; the testers numbered 11-20 performed the testsTesting of examples 4-6; the testers numbered 21-30 performed the tests of example 7 and comparative examples 1-2; the testers numbered 31-40 performed the tests of comparative examples 3-5.

TABLE 7

Table 7 (continuation)

As can be seen from the experimental results of table 7, the samples prepared in comparative example 1, comparative example 2, comparative example 3 and comparative example 5 had inferior moisturizing effect in the 4-hour moisturizing test, compared to the other samples. The short-term moisturizing effect of examples 1-7 was very significant. In addition, it can be seen from comparative example 3 that the barrier repair component (typically the phytosterols canola glycerides) has some moisturizing effect.

3.2 Long-term moisture test

Female subjects of 20-30 years old were selected for the moisturizing test using examples 2-4 as test samples. As test samples, the medial forearm area of the volunteer was 3.0cm X3.0 cm, and the amount of the sample was (2.0. + -. 0.1) mg/cm²(i.e., 0.0171g to 0.0189 g). The water content of the stratum corneum was measured as a value for the sample at the beginning and 28 days after the use of the product, respectively, and the results are shown in Table 8.

TABLE 8

From the results shown in Table 8, it can be seen that the special creams of examples 2 to 4 of the present invention have excellent moisturizing effects. Therefore, the special cream has excellent moisturizing effect.

The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. The skin repair special cream is characterized by comprising the following components:

anti-inflammatory repair component: 0.13% -13%;

moisture retention component: 1.02% -11.2%; and

barrier repair component: 0.11% -6%; wherein

2. The skin-repairing cream composition according to claim 1, wherein the polyhydric alcohol is added in an amount of 1 to 10% by mass based on the total mass of the skin-repairing cream composition; the addition amount of the ceramide is 0.01-1%; the addition amount of the hyaluronic acid or the salt thereof is 0.01-0.3%.

3. The skin-repairing cream according to claim 1 or 2, wherein the anti-inflammatory repair component comprises one or a combination of more than two of madecassoside, polypeptide, patchouli leaf extract and salvia miltiorrhiza extract;

4. The skin rejuvenation cream as claimed in claim 3 wherein said polypeptide comprises oligopeptide-1 and/or palmitoyl tetrapeptide-7.

5. The skin rejuvenation cream as claimed in any one of claims 1 to 4 wherein the barrier repair component comprises ceramides and/or phytosterol canola glycerides;

6. The skin rejuvenation cream as claimed in any one of claims 1 to 5 further including one or a combination of two or more of emulsifiers, emollient oils, thickeners and preservatives;

7. The skin rejuvenation cream as defined in claim 6 wherein said emulsifier comprises one or a combination of two or more of lecithin, PEG-20 methyl glucose sesquistearate, methyl glucose sesquistearate.

8. The skin rejuvenation cream as claimed in claim 6 or claim 7 wherein the thickener comprises one or a combination of two or more of carbomer, ammonium acryloyldimethyltaurate/VP copolymer, acrylic acid/C10-30 alkanol acrylate crosspolymer.

9. The skin rejuvenation cream as claimed in any one of claims 6 to 8 wherein said emollient oil comprises one or a combination of two or more of dimethicone, shea butter, caprylic/capric triglyceride, dimethiconol and squalane.

10. A method of making a skin rejuvenation benefit cream according to any one of claims 1 to 9 which includes the step of mixing the components of the skin rejuvenation benefit cream.