CN113368022A - Cream with moisturizing and skin brightening effects and preparation method thereof - Google Patents

Cream with moisturizing and skin brightening effects and preparation method thereof Download PDF

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CN113368022A
CN113368022A CN202110693987.XA CN202110693987A CN113368022A CN 113368022 A CN113368022 A CN 113368022A CN 202110693987 A CN202110693987 A CN 202110693987A CN 113368022 A CN113368022 A CN 113368022A
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skin
extract
moisturizing
cream
brightening
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CN113368022B (en
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黄斌斌
胡波
陈爱波
易玉华
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Guangzhou Uzen Cosmetics Academy Co ltd
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Guangzhou Uzen Cosmetics Academy Co ltd
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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    • A61K8/9794Liliopsida [monocotyledons]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
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Abstract

The invention discloses a cream with moisturizing and skin-brightening effects and a preparation method thereof, aiming at providing a cream which has good moisturizing and skin-brightening effects and does not cause secondary damage to skin, and the technical key points of the cream are as follows: OZA 003.003 emulsifier 1.0-3.0%, hydrogenated lecithin 0.5-3.0%, hydrogenated rapeseed oleyl alcohol 1.0-3.0%, emollient 5.0-20.0%, poly-gamma-sodium glutamate 0.01-0.3%, sodium hyaluronate 0.02-0.2%, skin brightening composition 1.0-10.0%, moisturizing composition 1.0-10.0%, 1, 3-propylene glycol 2.0-10.0%, Chondrus crispus extract 0.05-0.5%, phytosterol macadamia oleate 0.1-0.5%, abelmoschus moschatus seed oil 1.0-3.0%, preservative 0.5-2.0%, tocopherol (vitamin E) 0.05-0.5%, tetrasodium glutamate diacetate 0.05-0.15%, abelmoschus moschatus pure water 5.0-20.0%, deionized water to 100%; belongs to the technical field of cosmetics.

Description

Cream with moisturizing and skin brightening effects and preparation method thereof
Technical Field
The invention discloses a cream, in particular to a cream with the effects of moisturizing and brightening skin, and also discloses a preparation method of the cream, belonging to the technical field of cosmetics.
Background
The cream is a commonly used skin care product between emulsions and creams, is usually water-in-oil type, has heavier texture compared with emulsions and thinner texture compared with creams, and therefore has wider use population and is more popular in the market.
However, the skin feel of the cream in the current market is still sticky and the absorption effect is poor, so as to solve the technical problems, Chinese patent CN202011631204.7 provides a refreshing water-in-oil type cream without silicone oil, which is prepared from 0.5-3% of PEG-30 dipolyhydroxystearate, 0.5-3% of polyglycerol-3 diisostearate and 15-30% of isononyl isononanoate; the phase B consists of the following components: 0.02-0.1% of EDTA disodium, 0.5-2% of sodium chloride, 0.3-0.5% of p-hydroxyacetophenone, 0.05-0.1% of ethylhexyl glycerin, 0.3-1% of 1, 2-hexanediol, 2-10% of glycerin, 2-10% of butanediol, 0.5-5% of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin and the balance of water, wherein the method adopts non-silicone oil and emulsifier which are green to the environment and have good skin-friendly effect, and the water-soluble moisturizing oil of PEG/PPG/polytetramethylene glycol-8/5/3 glycerin is added into the water-in-oil type cream, so that the viscosity stability of the water-in-oil type cream can be obviously improved, and the prepared cream has stable performance and good rheological property, and takes PEG-30 dipolyhydroxystearate and polyglyceryl-3 diisostearate as an emulsification system, the skin care lotion has light and non-greasy skin feel, but the lotion has single effect and is difficult to meet the basic requirements of people on the use of skin care products, such as moisture retention, skin brightening and the like.
Therefore, the cream which can really solve the problem of skin, has good moisturizing and skin brightening effects and does not cause secondary damage to the skin is developed.
Disclosure of Invention
In view of the above problems, a first object of the present invention is to provide a cream having good moisturizing and skin-lightening effects without causing secondary damage to the skin.
The second purpose of the invention is to provide a preparation method of the cream.
Therefore, the technical scheme provided by the invention is as follows:
a cream with moisturizing and skin-brightening effects comprises the following components in percentage by weight: OZA 003.003 emulsifier 1.0-3.0%, hydrogenated lecithin 0.5-3.0%, hydrogenated rapeseed oleyl alcohol 1.0-3.0%, emollient 5.0-20.0%, poly-gamma-sodium glutamate 0.01-0.3%, sodium hyaluronate 0.02-0.2%, skin brightening composition 1.0-10.0%, moisturizing composition 1.0-10.0%, 1, 3-propylene glycol 2.0-10.0%, Chondrus crispus extract 0.05-0.5%, phytosterol macadamia oleate 0.1-0.5%, abelmoschus moschatus seed oil 1.0-3.0%, preservative 0.5-2.0%, tocopherol (vitamin E) 0.05-0.5%, tetrasodium glutamate diacetate 0.05-0.15%, abelmoschus moschatus pure water 5.0-20.0%, and deionized water to 100%.
Preferably, the cream with the effects of moisturizing and brightening the skin comprises at least two of shea butter, sunflower seed oil, jojoba seed oil, sweet almond oil, macadamia nut oil, safflower seed oil, coconut oil, rice bran oil, calendula seed oil, camellia oleosa seed oil, sesame seed oil and perilla seed oil.
Preferably, the skin-brightening cream with the moisturizing effect mainly comprises an abelmoschus manihot extract, a glycyrrhiza glabra root extract, a lentil fruit extract, a lithospermi pseudochinensis extract and a single hawthorn flower extract.
Preferably, the cream with the moisturizing and skin-brightening effects further comprises lemon fruit extract and sanguisorba officinalis root extract.
Preferably, the moisturizing composition comprises the tremella fruiting body extract, lonicera macranthoides extract, oregano leaf extract and lily flower extract.
Preferably, the moisturizing cream with the moisturizing and skin-brightening effects further comprises aloe vera leaf juice and an extract of radix ophiopogonis.
Preferably, the cream with the effects of moisturizing and brightening the skin is prepared from 1, 2-hexanediol, caprylic glycol, ethylhexyl glycerol, glyceryl caprylate and p-hydroxyacetophenone in a mass ratio of 5: 1: 1: 1: 2.
Preferably, the OZA003 emulsifier is composed of cetearyl olive oleate, polyglycerol-6 polyricinoleate, glycerol stearate and coco glucoside according to the mass ratio of 5:2:1: 2.
Preferably, the cream with the moisturizing and skin-brightening effects is prepared by the following steps:
1) cleaning the abelmoschus manihot with clear water, naturally drying, and crushing for later use;
2) weighing 80-100 mass times of deionized water and 8-12 mass times of butanediol of the abelmoschus manihot respectively, adding the abelmoschus manihot processed in the step 1) into an ultrasonic extractor;
3) starting stirring, setting the ultrasonic time at 25-35min, extracting at the ultrasonic power of 700- & ltSUB & gt 900 & lt/SUB & gt and the frequency of 15-25kHz, repeating the extraction for 3 times, combining the filtrates, and concentrating under reduced pressure until the concentration is W/V1: 1;
4) filtering the extract with a suction filtration device to 5L, storing in a tank, standing for 30min, collecting supernatant liquid, placing the glass crucible into a suction filtration bottle, and filtering with a circulating water type multipurpose vacuum pump to obtain the herba Abelmoschi Manihot extract.
The second technical scheme provided by the invention is as follows:
the preparation method of the cream with the moisturizing and skin-brightening effects sequentially comprises the following steps:
1) weighing each substance, and grouping;
group a (pre-dissolve): OZA003 emulsifier, hydrogenated rapeseed oleyl alcohol, emollient, phytosterin macadamia oleate, okra seed oil, tocopherol (vitamin E);
group B: deionized water, poly gamma-sodium glutamate, sodium hyaluronate, carrageen crispus extract, 1, 3-propylene glycol and tetrasodium glutamate diacetate.
Group C: hydrogenated lecithin.
Group D: skin lightening compositions, moisturizing compositions;
group E: preservative and abelmoschus esculentus hydrosol;
2) uniformly mixing all the components in the group A in an oil phase container, stirring and heating to 78-83 ℃;
3) adding each component in the group B into an emulsifying homogenizing pot, stirring and heating until the temperature is 83-85 ℃, and dissolving and transparent;
4) slowly adding the dissolved component A into an emulsifying homogenizing pot, stirring and homogenizing at a high speed to obtain white emulsion;
5) adding the component C into an emulsifying pot, uniformly stirring, and homogenizing at high speed to obtain white emulsion;
6) keeping the temperature to 83-85 ℃, cooling after 20 minutes, vacuumizing to-0.03 mpa, cooling to below 45 ℃, adding the component D into an emulsifying pot, and stirring to obtain white emulsion;
7) adding the component E into an emulsifying pot, stirring at 25r/min for 10min, homogenizing at 5000r/min for 1min to obtain white cream, inspecting, filtering, and discharging.
Compared with the prior art, the technical scheme provided by the invention has the following advantages:
1. according to the technical scheme provided by the invention, poly-gamma-sodium glutamate, sodium hyaluronate, a skin brightening composition and the like are compounded, poly-gamma-sodium glutamate and sodium hyaluronate are used as deep moisturizing active ingredients of a skin bottom layer, and a medium flavonoid ingredient of the skin brightening composition can release natural free radical removal factors in a deep moisturizing membrane to achieve the effects of lasting moisturizing and skin color brightening.
2. According to the technical scheme provided by the invention, the plant self-moisturizing component, namely the saccharide and the amino acid moisturizing factor, are used as the substrate moisturizing layer, so that the dry state of the skin is improved in a multi-target-point and all-around manner, the moisture is supplemented and preserved, the skin is durably nourished, the skin is kept tender, glossy and elastic, and the dry and rough skin is effectively resisted.
3. According to the technical scheme provided by the invention, OZA003 emulsifier which is self-developed by the applicant is compounded with hydrogenated lecithin, hydrogenated rapeseed oleyl alcohol, an emollient, phytosterol macadamia oleate, abelmoschus seed oil, tocopherol (vitamin E) and the like to form an emulsifier, oil is used for forming an oil moisturizing protective film, and a moisturizing composition is combined to promote the formation of a horny layer moisturizing NMF factor, so that the skin barrier function can be enhanced, the moisture can be kept for a long time, and dry and rough skin can be moisturized.
4. According to the technical scheme provided by the invention, all substances in the skin brightening composition are compounded with each other, so that an antagonist of a melanocyte hormone alpha-MSH in a melanin synthesis process is effectively promoted, a strong scavenging effect on hydroxyl free radicals and superoxide free radicals is realized, and the generation of tyrosinase induced by the alpha-MSH and the generation of melanocyte tyrosinase is reduced; the skin brightening composition can inhibit the formation of melanin in skin and an antagonist through compounding, and has the moisturizing effect, so that the dark yellow skin is promoted to be white and bright.
5. The technical scheme provided by the invention is characterized in that the plant extract active substance is prepared from active substance raw materials and grease, the green degree is more than 90%, the plant extract active substance is lasting and effective, secondary damage to skin is avoided, the moisturizing, skin-brightening and repairing effects are achieved, the plant extract active substance is easy to absorb, and skin allergy caused by pore blockage is avoided.
Drawings
FIG. 1 is an average of skin moisture content at various time points after sample use;
FIG. 2 is the rate of change of skin moisture content from the initial value at each time point after sample use.
Detailed Description
The following claims are hereby incorporated into the detailed description of the present invention, with the understanding that the present disclosure is not to be considered as limiting, and that modifications made by anyone within the scope of the present invention may be made without departing from the scope of the present invention.
It is noted that, unless otherwise indicated, the various components used in the present invention are all materials known in the art, and are either commercially available or prepared by known methods.
Wherein: the yellow leaf anemone production place is provided by Guangdong Shifeng agricultural science and technology company, Ingde, Qingyuan, of China, and butanediol is purchased in xylonite of Japanese company of the production place; an ultrasonic extractor SCIENTZ-5T is used for purchasing Ningbo Xinzhi biological science and technology company, a juicer L13-Y91S is used for purchasing a Jiuyang Hengsu company and a glass crucible, the aperture is 16-30 mu m and is about 30mL, and a circulating water type multi-purpose vacuum pump SHB-III is used for purchasing Zhengzhou Changcheng industrial and trade company.
Example 1
The invention provides a cream with moisturizing and skin-brightening effects, which comprises the following components in percentage by weight: OZA 003.003 emulsifier 2.0%, hydrogenated lecithin 0.5%, hydrogenated rapeseed oleyl alcohol 3.0%, shea butter fruit resin 3.0%, sunflower seed oil 7.0%, poly-gamma-sodium glutamate 0.05%, sodium hyaluronate 0.03%, yellow sunflower extract 1%, glycyrrhiza glabra root extract 1%, lentil fruit extract 1%, echeveria glauca extract 1%, single hawthorn flower extract 1%, tremella entity extract 0.5%, piluliflower honeysuckle extract 0.5%, oregano leaf extract 0.5%, lilium candidum flower extract 0.5%, 1, 3-propanediol 4.5%, Chondrus crispa extract 0.08%, phytosterin macadamia oleate 0.2%, yellow sunflower seed oil 1.5%, preservative 2.0%, tocopherol (vitamin E) 0.2%, tetrasodium glutamate diacetate 0.1%, yellow sunflower hydrosol 8.0%, deionized water to 100%.
Example 2
The invention provides a cream with moisturizing and skin-brightening effects, which comprises the following components in percentage by weight: OZA003 emulsifier 2.0%, hydrogenated lecithin 2.0%, hydrogenated rapeseed oleyl alcohol 2.0%, shea butter fruit resin 1.0%, jojoba seed oil 5.0%, sweet almond oil 5.0%, macadamia nut oil 3.5%, safflower seed oil 3.0%, poly-gamma-sodium glutamate 0.1%, sodium hyaluronate 0.1%, yellow sunflower extract 0.5%, Glycyrrhiza glabra root extract 1%, lentil fruit extract 0.5%, Eucheuma pumila extract 1%, Crataegus monogyna flower extract 2%, Tremella fuciformis solid extract 1%, Lonicera pilifera L.extract 0.5%, oregano vulgaris leaf extract 1%, Lilium albo flower extract 0.5%, 1, 3-propylene glycol 2.0%, Chondrus crispa extract 0.2%, phytosterol macadamia oleate 0.5%, yellow sunflower seed oil 2.0%, preservative 1.5%, tocopherol (vitamin E) 0.45%, tetrasodium glutamate diacetate 0.15%, and yellow sunflower hydrosol 6.0%, deionized water to 100%.
Example 3
The invention provides a cream with moisturizing and skin-brightening effects, which comprises the following components in percentage by weight: OZA003 emulsifier 1.0%, hydrogenated lecithin 3.0%, hydrogenated rapeseed oleyl alcohol 1.0%, coconut oil 3.0%, calendula seed oil 2.0%, rice bran oil 1.0%, poly-gamma-sodium glutamate 0.3%, sodium hyaluronate 0.02%, abelmoschus moschatus extract 2%, glycyrrhiza glabra root extract 1%, lentil fruit extract 2%, lithospermi pseudochinensis extract 2%, crataegus pinnatifida flower extract 3%, tremella fuciformis entity extract 2%, lonicera tomentosa extract 1%, oregano leaf extract 1%, lilium candidum flower extract 1%, 1, 3-propylene glycol 8.0%, Chondrus crispa extract 0.15%, phytosterin macadamia oleate 0.3%, abelmoschus seed oil 1.0%, antiseptic 1.2%, tocopherol (vitamin E) 0.1%, tetrasodium glutamate diacetate 0.05%, abelmoschus moschatus chinensis pure water 20.0%, deionized water to 100%.
Example 4
The invention provides a cream with moisturizing and skin-brightening effects, which comprises the following components in percentage by weight: OZA 003.0% emulsifier, 0.5% hydrogenated lecithin, 2.5% hydrogenated rapeseed oleyl alcohol, 0.5% shea butter, 5.0% jojoba seed oil, 5.0% camellia seed oil, 1.5% safflower seed oil, 3.0% sesame seed oil, 0.2% poly-gamma-sodium glutamate, 0.15% sodium hyaluronate, 0.5% yellow nightshade extract, 0.5% glycyrrhiza glabra root extract, 0.5% lentil fruit extract, 0.5% pseudobulbus chingii herb extract, 0.5% single hawthorn flower extract, 2% lemon fruit extract, 2% sanguisorba officinalis root extract, 2% tremella entity extract, 2% lonicera mauritiana makino extract, 2% oregano leaf extract, 2% lilium bailii flower extract, 1% aloe barbadensis leaf juice, 1% ophiopogon root extract, 1% 1.3.0% propylene glycol, 0.5% carrageenin extract, 0.1% phytosterol oleate, 3.0.0% yellow chinaberry seed oil, 0.5% preservative, 0.3 percent of tocopherol (vitamin E), 0.08 percent of tetrasodium glutamate diacetate and 10.0 percent of abelmoschus moschatus pure dew to 100 percent of deionized water.
Example 5
The invention provides a cream with moisturizing and skin-brightening effects, which comprises the following components in percentage by weight: OZA003 emulsifier 3.0%, hydrogenated lecithin 1.5%, hydrogenated rapeseed oleyl alcohol 1.8%,: shea butter 2.0%, jojoba seed oil 5.0%, coconut oil 5.0%, macadamia nut seed oil 5.0%, sunflower seed oil 7.0%, perilla seed oil 1.0%, poly-gamma-sodium glutamate 0.01%, sodium hyaluronate 0.18%, yellow sunflower extract 2%, glycyrrhiza glabra root extract 1%, lentil fruit extract 1%, lithospermum extract 1%, crataegus monogynura flower extract 1%, lemon fruit extract 1%, sanguisorba officinalis root extract 1%, tremella alba entity extract 2%, lonicera tomentosa extract 1%, oregano grandiflora leaf extract 2%, lilium bailii flower extract 1%, aloe barbadensis leaf juice 1%, ophiopogon root extract 1%, 1, 3-propylene glycol 10.0%, carrageenin extract 0.05%, phytosterol macadamia oleate 0.4%, yellow sunflower seed oil 2.5%, preservative 1.6%, tocopherol (vitamin E) 0.5%, 0.12 percent of tetrasodium glutamate diacetate and 12.0 percent of abelmoschus moschatus hydrosol, and deionized water is added to reach 100 percent.
The preservative described in examples 1 to 5 was prepared from 1, 2-hexanediol, caprylyl glycol, ethylhexyl glycerin caprylate, p-hydroxyacetophenone in a mass ratio of 5: 1: 1: 1: 2.
The OZA003 emulsifier described in examples 1 to 5 consists of cetearyl olive oleate, polyglycerol-6 polyricinoleate, glycerol stearate, coco glucoside in a mass ratio of 5:2:1: 2.
The preparation method of the cream with moisturizing and skin-brightening effects described in examples 1 to 5 sequentially comprises the following steps:
1) weighing the components according to the weight numbers in the embodiments 1 to 5, and grouping;
group a (pre-dissolve): OZA003 emulsifier, hydrogenated rapeseed oleyl alcohol, emollient, phytosterin macadamia oleate, okra seed oil, tocopherol (vitamin E);
group B: deionized water, poly gamma-sodium glutamate, sodium hyaluronate, Chondrus crispus extract, tetrasodium glutamate diacetate, and 1, 3-propylene glycol;
group C: hydrogenated lecithin;
group D: skin lightening compositions, moisturizing compositions;
group E: preservative and abelmoschus esculentus hydrosol;
2) the specific implementation production process is as follows:
2.1) weighing the raw materials of the group A, uniformly mixing in an oil phase container, stirring and heating to 78-83 ℃ at the speed of 30r/min by using a stirrer.
2.2) weighing the raw materials in the group B, adding the raw materials into an emulsification and homogenization pot in sequence, and heating the mixture to 83-85 ℃ at the speed of 25r/min by using a stirrer for dissolving and transparency.
2.3) slowly adding the dissolved group A into an emulsifying and homogenizing pot, stirring at the speed of 30r/min, and homogenizing at the high speed of 10000r/min for 5 minutes to obtain white emulsion.
2.4) weighing the raw materials of the group C, adding the raw materials into an emulsifying pot, stirring at the speed of 30r/min, and homogenizing at the high speed of 10000r/min for 5 minutes to obtain white emulsion.
2.5) keeping the temperature to 83-85 ℃, cooling after 20 minutes, and vacuumizing to-0.03 mpa.
2.6) cooling to below 45 ℃, respectively weighing the raw materials in the group D, adding the raw materials into an emulsifying pot, and stirring at the speed of 25r/min for 20min to obtain white emulsion.
2.7) respectively weighing the raw materials of the group E, adding the raw materials into an emulsifying pot, stirring for 10min at the speed of 25r/min, and homogenizing for 1min at the speed of 5000r/min to obtain white cream.
2.8) filtering and discharging after the inspection is qualified.
3) The internal control standard is as follows:
appearance: white flowable creams;
pH value: 5.5 to 6.5
Stability (cold resistance): keeping 24H in a refrigerator at (-8 +/-2) DEG C, and no layering phenomenon exists after the temperature is restored to the room temperature;
stability (heat resistance): keeping 24H in a constant temperature box at (40 +/-1) DEG C, and no layering phenomenon exists after the room temperature is recovered;
centrifuging: 3000r/min, 20min, no oil-water separation phenomenon;
total number of bacterial colonies: less than 10 CFU/g;
total number of mold and yeast: less than 10 CFU/g;
coliform resistant bacteria: cannot be detected;
staphylococcus aureus: cannot be detected;
pseudomonas aeruginosa: cannot be detected;
methanol: < 2000mg/kg
Lead: less than 10mg/kg
Mercury: < 1mg/kg
Arsenic: < 2mg/kg
Cadmium: less than 5mg/kg
In order to better prove the invention, the following comparative experiments in the development process of the technical scheme provided by the application are given:
comparative example 1
The composition and content were the same as in example 5, except that OZA003 emulsifier was replaced with hydrogenated lecithin.
Comparative example 2
The composition and content were the same as in example 5, except that the okra extract was not contained in the skin lightening composition and the missing components were supplemented with an equal amount of deionized water.
Comparative example 3
The composition and content were identical to those of example 5, except that the skin lightening composition contained no extract of gelidium amansii and the missing components were supplemented with an equal amount of deionized water.
Comparative example 4
The composition and content were the same as in example 5, except that aloe vera leaf juice was used instead of the moisturizing composition.
Comparative example 5
The composition and content thereof were identical to those of example 5, except that the lonicera macranthoides extract was used instead of the moisturizing composition.
The preparation method is consistent with the preparation method provided in the examples.
In order to prove the technical points of the technical scheme provided by the application, the experimental data of examples 1 to 5 and comparative examples 1 to 5 provided by the application are given below.
1. Moisture retention test:
1. 1 the moisturizing efficacy and the smoothing effect on dryness-induced roughness and shavings of examples 1, 4, 5 and comparative examples 1, 4, 5 were evaluated by 24H human body moisturizing test; and skin feel evaluation was performed by a panel of experts.
The number of volunteers: 30 women with 5 persons in each group
Age: 25-35 years old
Test area: antebrachial flexion
And (3) testing period: 24H
1.2 testing instrument
1.2.1 skin moisture content tester (Corneometer CM825)
The skin moisture content tester Corneometer (CM 825, Courage and Khazaka, Germany) measures on the basis of the principle of capacitance. Water has a dielectric constant of 81, other substances generally have a dielectric constant of less than 7, and water is the substance with the highest dielectric constant on the skin. When the moisture content changes, the capacitance of the skin also changes, so the moisture content on the skin surface can be analyzed by measuring the capacitance of the skin. The greater the skin moisture content value, the higher the skin moisture content.
1.2.2 dermoscopy system (medical 800HD)
The dermoscopy system (medical 800HD, fotofinder systems GmbH, Birbach, germany) is a non-invasive examination device that can amplify skin lesions and can also show the epidermis and the superficial layers of the dermis through the stratum corneum of the epidermis, and observe microscopic structures, such as pigments and vascular structures, that are not visible to the naked eye. In the test, a skin photo is collected at a magnification of 50 times, and the fine wrinkles and dandruff conditions of the skin are observed. The dry skin is often accompanied by raised tiny scaly dandruff in the grain gaps, the fine lines of the skin are more obvious due to the dandruff among the grains, and the skin looks dry and rough. Excessive dryness of the skin causes more severe flaking, white flakes are observed in the image, and raised flakes make the skin feel stroked and feel a large frictional resistance and poor moisturized feel.
1.3 calculation formula
Initial value: refers to the base value when no product is used.
Mean value
Figure BDA0003127306660000081
Where x is the individual parameter measurement and n is the number of valid data
Difference from initial value xTAfter use-xTsBefore use
Figure BDA0003127306660000091
1.4 test results:
the results of the skin moisture content test before the sample was used and 1h, 4h, 8h and 24h after the sample was used are shown in table 1 and fig. 1 and 2. The greater the skin moisture content value, the greater the skin moisture content.
Table 1 average values of skin moisture content and statistical methods before and after 1h, 4h, 8h and 24h of sample application: t test
The significance is as follows: "**": p < 0.05; "*": p is more than or equal to 0.01 and less than 0.05; "+": p is more than or equal to 0.05; "-": p is more than or equal to 0.1
Table 1 skin moisture test results
Figure BDA0003127306660000092
Figure BDA0003127306660000101
And (4) conclusion: as can be seen from Table 1 and FIGS. 1 and 2, the skin moisture content was significantly increased at each time point after use in examples 1, 4 and 5 (1h, 4h and 8 h: P <0.05, 24h: P < 0.01) compared to before use, and the change rate was 20.78% or more after 24h use, whereas the change rate was 6.26% or less after 24h use in comparative examples 1, 4 and 5, indicating that examples 1, 4 and 5 are significantly superior to comparative examples 1, 4 and 5 in having strong moisture retention properties.
1.5 sensory evaluation of skin
The skin sensory evaluation was carried out by the panelists on the skin after application of the samples, with a score of 0 to 5, and the test results are shown in table 2, and the higher the score, the more obvious the feeling was.
TABLE 2 sensory evaluation of skin after sample application
Figure BDA0003127306660000102
And (4) conclusion: as can be seen from Table 1, examples 1, 4 and 5 have significant moisturizing effect and also have significant skin elasticity and absorption, and when applied to the skin, the skin is moist, smooth, moisture-retaining and elastic.
2.1 skin lightening efficacy evaluation:
test protocol
30 suitable volunteers were selected for testing (criteria for enrollment: 25-35 years old, dark skin color, skin color classified as medium skin color (i.e., ITA ° value between 28-41). the volunteers were divided into 6 groups of 5 persons, 1-3 groups of full faces used with the products of examples 1-3, 4-6 groups of full faces used with the products of comparative examples 1-3, respectively.A change in skin condition index before use, 2 weeks after use, 4 weeks was measured by 4 consecutive weeks of trial ((0, 2, 4 weeks of visit)), and the efficacy of skin lightening was evaluated by comparison of the face condition of the volunteers after use with that of the products before use in the schemes of examples 1-3 and comparative examples 1-3.
Temperature: 20-22 ℃, relative humidity: 40 to 60 percent
The data are respectively expressed as: 0W, 2W and 4W.
Evaluation method
The 1.5.2.2 dermoscope system (medical 800HD) for the test instrument provides safe, stable standard lighting conditions, and all camera settings and imaging parameter settings are controlled by software to ensure stability and standardization of imaging. The instrument has multiple light source modes: standard light, blue light, orange light, cross polarized light and parallel polarized light can be used for carrying out multi-angle imaging on facial skin, and the imaging quality can reach up to 2000 ten thousand pixels. The face of the subject is shot in the test, and the following evaluation parameters are analyzed by selecting a standard 2 light source picture:
skin brightness L: degree of skin lightening. Skin brightness L of selected areas (smeared in any area);
skin yellowness b: degree of skin yellowing. Skin yellowness b of selected areas (applied to either area);
skin whiteness ITA °: degree of skin whitening. L, b from the above analysis are calculated by the following formula:
ITA=(Arc tan(L*-50)/b*)×180/π
1.3.3 facial imaging test (medical 800HD) results of skin brightness L, skin yellowness b, skin whiteness ITA ° analysis and statistics for any area painted before use (initial value), after 2 weeks, 4 weeks of use are shown in table 3 and table 4 below. (average value retains 2 decimal places)
Skin brightness L: the greater the skin brightness L, the brighter the skin;
skin yellowness b; the greater the skin yellowness b, the darker the skin;
skin whiteness ITA °: the greater the skin whiteness ITA °, the whiter the skin.
Examples 1-3 pre-use (initial value), 2 weeks use, 4 weeks later image analysis-color analysis and statistics (n ═ 5)
Figure BDA0003127306660000111
Figure BDA0003127306660000121
Table 4 image analysis-color analysis and statistics (n ═ 5) before (initial) use, after 2 weeks, 4 weeks of use for comparative examples 1-3
Figure BDA0003127306660000122
According to the skin lightening efficacy test of the examples 1-3 and the comparative examples 1-3, compared with the initial value, after the scheme of the examples 1-3 is continuously used for 4 weeks, the skin whiteness ITA (International organization for standardization) reaches 23.68, the effect is remarkable, and the skin color can be effectively lightened; in contrast, in comparative examples 1 to 3, the skin whiteness ITA ° was 14.62 or less after 4 weeks of continuous use, and the effect was not significant.

Claims (10)

1. The cream with the effects of moisturizing and brightening the skin is characterized by comprising the following components in percentage by weight: OZA 003.003 emulsifier 1.0-3.0%, hydrogenated lecithin 0.5-3.0%, hydrogenated rapeseed oleyl alcohol 1.0-3.0%, emollient 5.0-20.0%, poly-gamma-sodium glutamate 0.01-0.3%, sodium hyaluronate 0.02-0.2%, skin brightening composition 1.0-10.0%, moisturizing composition 1.0-10.0%, 1, 3-propylene glycol 2.0-10.0%, Chondrus crispus extract 0.05-0.5%, phytosterol macadamia oleate 0.1-0.5%, abelmoschus moschatus seed oil 1.0-3.0%, preservative 0.5-2.0%, tocopherol (vitamin E) 0.05-0.5%, tetrasodium glutamate diacetate 0.05-0.15%, abelmoschus moschatus pure water 5.0-20.0%, and deionized water to 100%.
2. The cream with the effects of moisturizing and brightening the skin as claimed in claim 1, wherein the emollient comprises at least two of shea butter, sunflower seed oil, jojoba seed oil, sweet almond oil, macadamia nut oil, safflower seed oil, coconut fruit oil, rice bran oil, calendula seed oil, camellia oil, sesame seed oil and perilla seed oil.
3. The cream with the effects of moisturizing and brightening skin of claim 1, wherein the skin brightening composition mainly comprises an extract of abelmoschus manihot, an extract of glycyrrhiza glabra root, an extract of lentil fruit, an extract of lithospermum pseudosciaenae, and an extract of crataegus monogyna flower.
4. The cream with the effects of moisturizing and brightening skin of claim 1, wherein the skin brightening composition further comprises lemon fruit extract and sanguisorba officinalis root extract.
5. The cream with the effects of moisturizing and brightening the skin as claimed in claim 1, wherein the moisturizing composition comprises a tremella fruiting body extract, a lonicera villosa Thunb extract, a oregano leaf extract and a lilium brownii flower extract.
6. The cream with moisturizing and skin-lightening effects of claim 1, wherein the moisturizing composition further comprises aloe vera leaf juice and ophiopogon root extract.
7. The cream with the effects of moisturizing and brightening the skin as claimed in claim 1, wherein the preservative is prepared from 1, 2-hexanediol, caprylyl glycol, ethylhexyl glycerin caprylate, p-hydroxyacetophenone in a mass ratio of 5: 1: 1: 1: 2.
8. The cream with the effects of moisturizing and brightening the skin as claimed in claim 1, wherein the OZA003 emulsifier is composed of cetearyl olive oleate, polyglycerol-6 polyricinoleate, glyceryl stearate and coco glucoside according to a mass ratio of 5:2:1: 2.
9. The cream with the effects of moisturizing and brightening the skin as claimed in claim 1, wherein the abelmoschus esculentus extract is prepared by the following method:
1) cleaning the abelmoschus manihot with clear water, naturally drying, and crushing for later use;
2) weighing 80-100 mass times of deionized water and 8-12 mass times of butanediol of the abelmoschus manihot respectively, adding the abelmoschus manihot processed in the step 1) into an ultrasonic extractor;
3) starting stirring, setting the ultrasonic time at 25-35min, extracting at the ultrasonic power of 700- & ltSUB & gt 900 & lt/SUB & gt and the frequency of 15-25kHz, repeating the extraction for 3 times, combining the filtrates, and concentrating under reduced pressure until the concentration is W/V1: 1;
4) filtering the extract with a suction filtration device to 5L, storing in a tank, standing for 30min, collecting supernatant liquid, placing the glass crucible into a suction filtration bottle, and filtering with a circulating water type multipurpose vacuum pump to obtain the herba Abelmoschi Manihot extract.
10. The preparation method of the cream with the effects of moisturizing and brightening the skin as claimed in claim 1 is characterized by sequentially comprising the following steps:
1) weighing the components according to the components in the claim 1, and grouping;
group a (pre-dissolve): OZA003 emulsifier, hydrogenated rapeseed oleyl alcohol, emollient, phytosterin macadamia oleate, okra seed oil, tocopherol (vitamin E);
group B: deionized water, poly gamma-sodium glutamate, sodium hyaluronate, carrageen crispus extract, 1, 3-propylene glycol and tetrasodium glutamate diacetate.
Group C: hydrogenated lecithin.
Group D: skin lightening compositions, moisturizing compositions;
group E: preservative and abelmoschus esculentus hydrosol;
2) uniformly mixing all the components in the group A in an oil phase container, stirring and heating to 78-83 ℃;
3) adding each component in the group B into an emulsifying homogenizing pot, stirring and heating until the temperature is 83-85 ℃, and dissolving and transparent;
4) slowly adding the dissolved component A into an emulsifying homogenizing pot, stirring and homogenizing at a high speed to obtain white emulsion;
5) adding the component C into an emulsifying pot, uniformly stirring, and homogenizing at high speed to obtain white emulsion;
6) keeping the temperature to 83-85 ℃, cooling after 20 minutes, vacuumizing to-0.03 mpa, cooling to below 45 ℃, adding the component D into an emulsifying pot, and stirring to obtain white emulsion;
7) adding the component E into an emulsifying pot, stirring at 25r/min for 10min, homogenizing at 5000r/min for 1min to obtain white cream, inspecting, filtering, and discharging.
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