CN109077972A - Moisturiser and preparation method thereof - Google Patents
Moisturiser and preparation method thereof Download PDFInfo
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- CN109077972A CN109077972A CN201811302131.XA CN201811302131A CN109077972A CN 109077972 A CN109077972 A CN 109077972A CN 201811302131 A CN201811302131 A CN 201811302131A CN 109077972 A CN109077972 A CN 109077972A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of moisturiser and preparation method thereof.In terms of the mass percent of the moisturiser, the moisturiser includes following components: grease: 5-40%, preferably 10-35%, more preferable 15-35%；Emulsifier: 2.1-20%, preferably 2.5-10%, more preferable 3-8%；Moisturizer: 1-40%, preferably 5-30%, more preferable 10-25%；Thickener: 0-2%, preferably 0.1-2%, more preferable 0.1-1%；Skin conditioning agent: 1-10%, preferably 2-10%, more preferable 5-10%；The emulsifier includes compound emulsifying agent, the compound emulsifying agent be -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol (and) cetanol.Moisturiser of the invention can form the persistently moist and increased protective film of moisturizing degree on a skin surface, be a kind of bionics skin sebum film.
Description
Technical field
The present invention relates to a kind of moisturisers and preparation method thereof, belong to cosmetic field.
Background technique
Due to various factors, such as: skin aging caused by the growth at age, the pressure from external environment, outside and
The violent temperature difference between internal environment, environmental pollution and skin heat ageing caused by frequent Irrigation and direct sunlight
Deng making skin become drying, the cuticula of skin caused to fall off.Therefore, skin seems coarse, fragile, dry and obscure.
Currently, people think that dry skin is since skin surface lacks lipid material unilaterally.Actually only in skin
Grease is smeared on surface, and skin can not be made to become soft.Because skin true cause is cuticula water deficient, cuticula control is outer
The severe edema due to hypofunction of the spleen point plays the role of barrier, and to keep moisture of skin balance, cuticula should keep certain moisture, fight external environment
Humidity variation will make skin smooth, soft and high resilience, it is necessary to be that skin keeps certain moisture content, usual skin water
Content is divided to keep 10%-20%.
Raw material with moisture-keeping functions is mainly roughly divided into two classes, a kind of moisturizer, such as glycerol, third by Traditional makeup
Glycol etc., by water imbibition moisturizing, but it there is no the water lock moisturizing to skin, lasting aspect of nourishing fully considers.It is another
Class nonpolarity moisturizer, such as vaseline and White Mineral Oil, they form one layer of closure oil film on surface, to reduce skin surface
The evaporation of moisture, the tissue moisture diffusion of lower layer is to cuticula, so that cuticula, which is further hydrated, reaches moisture-keeping function；But it should
Class moisturizer can make skin breathability poor, excessively greasy, cause use feeling poor, and it is negative to increase skin for oily skin consumer
Load, results in blocking pore, causes the risk of small pox acne skin.
In addition, in the prior art, there are also moisturizing cosmetics to be added to many both effectiveness moisturizing components, do not examine sufficiently
Consider and promote percutaneous absorbtion, so that many effect moisturizing constituent retentions do not enter into keratoderma, no in skin surface
Can effectively excite skin deep moisturizing ability, skin can not lasting moisturizing, lead to the waste of cosmetic industry component cost.
Summary of the invention
Problems to be solved by the invention
The technical problem to be solved by the present invention is to provide a kind of lasting moisturizing effect in view of the above shortcomings of the prior art
Fruit is good, alleviates dry skin, safe and non-stimulating moisturiser and preparation method thereof.Moisturiser of the invention can be in skin surface
It is upper to form the persistently moist and increased protective film of moisturizing degree, it is a kind of bionics skin sebum film.
The solution to the problem
The present invention provides a kind of moisturiser, wherein in terms of the mass percent of the moisturiser, including following components:
Grease: 5-40%, preferably 10-35%, more preferable 15-35%；
Emulsifier: 2.1-20%, preferably 2.5-10%, more preferable 3-8%；
Moisturizer: 1-40%, preferably 5-30%, more preferable 10-25%；
Thickener: 0-2%, preferably 0.1-2%, more preferable 0.1-1%；
Skin conditioning agent: 1-10%, preferably 2-10%, more preferable 5-10%；
The emulsifier includes compound emulsifying agent, the compound emulsifying agent be -6 distearate of polyglycereol (and) Jojoba
Esters (and) -3 beeswax acid esters of polyglycereol (and) cetanol.
Moisturiser according to the present invention, wherein the grease includes phytosterol Queensland nut oleate, Butyrospermum parkii fruit
Rouge, sunflower seed oil, glycerol three (thylhexoic acid) ester, coconut oil, caprylic/capric triglyceride, octyl dodecanol myristic acid
Ester, pentaerythrite four (thylhexoic acid) ester, cetanol ethylhexoate, dimethyl silicone polymer, dimethiconol and
The a combination of one or more of ring five dimethyl silicone polymer.
Moisturiser according to the present invention, wherein in addition to the compound emulsifying agent, the emulsifier further include lecithin,
- 6 distearate of polyglycereol, -3 beeswax acid esters of polyglycereol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, whale
The combination of one or more of wax stearyl alcohol, acrylic acid (ester) analog copolymer sodium.
Moisturiser according to the present invention, wherein in terms of the mass percent of the moisturiser, -6 distearyl of polyglycereol
- 3 beeswax acid esters of acid esters (and) Jojoba esters (and) polyglycereol (and) additional amount of cetanol is 2-6%.
Moisturiser according to the present invention, wherein the moisturizer includes 1,3-PD, 1,2-PD, pentanediol, mountain
Pears alcohol, glycerol, dipropylene glycol, 1,3 butylene glycol, trehalose, glycine betaine, xylitol, budding short stalk enzyme polysaccharide, glycerin polyether-
26, beta glucan, methyl gluceth -20, methyl gluceth -10, erythrulose, biological carbohydrate gum -1, rhamnose, second
The combination of one or more of acyl chitosamine, polyethylene glycols and Sodium Hyaluronate.
Moisturiser according to the present invention, wherein the thickener includes carbomer, xanthan gum, pectin, acacia
Glue, Scleroglucan, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymeric
The combination of one or more of object, Chondrus crispus extract and Sodium Polyacrylate.
Moisturiser according to the present invention, wherein the skin conditioning agent include tocopherol acetate, panthenol, Flos Chrysanthemi water,
Aloe barbadensis Miller leaf juice powder, polypeptide, niacinamide, oat beta-glucan, adenosine, Rosa centifolia flower extract, lavandulae flos water and accumulated snow
The combination of one or more of careless extract.
Moisturiser according to the present invention, wherein the moisturiser further includes preservative and/or odorant；With the moisturizing
The mass percent meter of frost, the additional amount of the preservative are 0.2-3%, preferably 0.2-2%, more preferable 0.2-1.5%；It is described
The additional amount of odorant is 0-0.2%, preferably 0.01-0.2%, more preferably 0.01-0.15%.
Moisturiser according to the present invention, wherein the moisturiser further include pH adjusting agent, free radical scavenger, chelating agent,
The combination of one or more of antioxidant, film forming agent, stabilizer, pigment.
The present invention also provides a kind of preparation methods of moisturiser according to the present invention comprising by each group of the moisturiser
The step of dividing mixing.
The effect of invention
Moisturiser of the invention can form the persistently moist and increased protective film of moisturizing degree on a skin surface, be
A kind of bionics skin sebum film.
Further, moisturiser of the invention can also capture the water-soluble active ingredient being dissolved in water, help activity
Ingredient is conducted to cuticular layer, and then improves skin barrier function, and transepidermal water is prevented to be lost.
Further, moisturiser of the invention also has lasting moistening effect, and mild, safe and non-stimulated, together
When with excellent skin sense.
Further, preparation method is simple for moisturiser of the invention, and raw material is easily obtained, and is suitble to high-volume raw
It produces.
Specific embodiment
It will be detailed below various exemplary embodiments, feature and aspect of the invention.Dedicated word " example herein
Property " mean " being used as example, embodiment or illustrative ".Here as any embodiment illustrated by " exemplary " should not necessarily be construed as
Preferred or advantageous over other embodiments.
In addition, in order to better illustrate the present invention, numerous details is given in specific embodiment below.
It will be appreciated by those skilled in the art that without certain details, the present invention equally be can be implemented.In other example,
Method well known to those skilled in the art, means, equipment and step are not described in detail, in order to highlight master of the invention
Purport.
The present invention provides a kind of moisturiser, in terms of the mass percent of the moisturiser, including following components:
Grease: 5-40%, preferably 10-35%, more preferable 15-35%；
Emulsifier: 2.1-20%, preferably 2.5-10%, more preferable 3-8%；
Moisturizer: 1-40%, preferably 5-30%, more preferable 10-25%；
Thickener: 0-2%, preferably 0.1-2%, more preferable 0.1-1%；
Skin conditioning agent: 1-10%, preferably 1.5-10%, more preferable 5-10%；
The emulsifier includes compound emulsifying agent, the compound emulsifying agent be -6 distearate of polyglycereol (and) Jojoba
Esters (and) -3 beeswax acid esters of polyglycereol (and) cetanol.
Moisturiser according to the present invention, wherein grease include phytosterol Queensland nut oleate, Butyrospermum parkii fruit rouge,
Sunflower seed oil, glycerol three (thylhexoic acid) ester, coconut oil, caprylic/capric triglyceride, octyl dodecanol myristinate,
Pentaerythrite four (thylhexoic acid) ester, cetanol ethylhexoate, dimethyl silicone polymer, dimethiconol and ring five
The a combination of one or more of dimethyl silicone polymer.
Preferably, in moisturiser of the invention, grease preferably comprises phytosterol Queensland nut oleate and Butyrospermum parkii
Fruit rouge；Wherein, in terms of the mass percent of the moisturiser, the additional amount of phytosterol Queensland nut oleate is 0.5-3%,
Such as the additional amount of phytosterol Queensland nut oleate can be 1%, 1.5%, 2%, 2.5% etc.；Butyrospermum parkii fruit rouge
Additional amount is 2-8%, such as: the additional amount of Butyrospermum parkii fruit rouge can be 3%, 4%, 5%, 6%, 7% etc..Phytosterol Australia
The additional amount of continent nut oleate is in the range of 0.5-3%, when the additional amount of Butyrospermum parkii fruit rouge is in the range of 2-8%,
The holding of skin moment can be enabled to moisten full, have the characteristics that dry skin of releiving.
In terms of the mass percent of the moisturiser, the additional amount of grease is 5-40%, preferably 10-35%, more preferably
For 15-35%；Such as: the additional amount of grease can be 20%, 25%, 30% etc..If the additional amount of grease less than 5%, is protected
The moistening effect of wet frost is undesirable；If the additional amount of grease be greater than 40%, moisturiser due to overweight greasy feeling will have compared with
The sense of touch of difference.
Moisturiser according to the present invention, in addition to the compound emulsifying agent, emulsifier can also include lecithin, gather it is sweet
Oily -6 distearates, -3 beeswax acid esters of polyglycereol, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, spermaceti are hard
The combination of one or more of lipidol and acrylic acid (ester) analog copolymer sodium.
In terms of the mass percent of the moisturiser, the additional amount of emulsifier is 2.1-20%, preferably 2.5-10%, more
Preferably 3-8%；Such as: the additional amount of emulsifier can be 4%, 5%, 6%, 7%, 12%, 14%, 16%, 18% etc..Such as
For the content of emulsifier described in fruit less than 2.1%, emulsifier is highly unstable；If the content of emulsifier is greater than 20%, moisturiser
There is poor sense of touch due to excessively thick and heavy.
In the present invention, -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol (and) whale
Ceryl alcohol can be commercially available through commercially available, can also be through being prepared.
- 3 beeswax acid esters of -6 distearate of polyglycereol of the invention (and) Jojoba esters (and) polyglycereol (and) spermaceti
In alcohol, with -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol (and) quality hundred of cetanol
Divide than meter, comprising: -6 distearate of polyglycereol of 60-70%, the Jojoba esters of 14-24%, the polyglycereol -3 of 3-13%
The cetanol of beeswax acid esters and 3-13%；Preferably, -6 distearate of polyglycereol (and) Jojoba esters (and) poly-
- 3 beeswax acid esters of glycerol (and) cetanol include 65% -6 distearate of polyglycereol, 19% Jojoba esters, 8% gather it is sweet
Oily -3 beeswax acid esters and 8% cetanol.
In the present invention, if -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol
(and) additional amount of cetanol is too low, the moistening effect of the moisturiser is undesirable, if -6 distearate of polyglycereol (and)
The additional amount of Jojoba esters (and) -3 beeswax acid esters of polyglycereol (and) cetanol is excessively high, and the skin sense of the moisturiser is undesirable.
Preferably, in terms of the mass percent of the moisturiser, -6 distearate of polyglycereol (and) Jojoba esters (and) poly-
- 3 beeswax acid esters of glycerol (and) additional amount of cetanol is 2-6%；Such as: 2%, 3%, 4%, 5% etc..
Moisturiser according to the present invention, wherein moisturizer includes 1,3-PD, 1,2-PD, pentanediol, sorb
Alcohol, glycerol, dipropylene glycol, 1,3 butylene glycol, trehalose, glycine betaine, xylitol, budding short stalk enzyme polysaccharide, glycerin polyether -26,
Beta glucan, methyl gluceth -20, methyl gluceth -10, erythrulose, biological carbohydrate gum -1, rhamnose, acetyl
The combination of one or more of chitosamine, polyethylene glycols and Sodium Hyaluronate.
In terms of the mass percent of the moisturiser, the additional amount of moisturizer is 1-40%, preferably 5-30%, more preferably
For 10-25%；Such as: the additional amount of moisturizer can be 8%, 12%, 15%, 18%, 20%, 22%, 28%, 32%,
35%, 38% etc..If the content of moisturizer, less than 1%, the lasting moisture retention of moisturiser will be unsatisfactory；If moisturizing
The content of agent is greater than 40%, and moisturiser has poor sense of touch since skin sense is sticky.
Moisturiser according to the present invention, wherein thickener include carbomer, xanthan gum, pectin, Arabic gum natural gum, it is small
Pyrenomycetes glue, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, wrinkle
The combination of one or more of wave Irish moss (CHONDRUS CRISPUS) extract and Sodium Polyacrylate.
In terms of the mass percent of the moisturiser, the additional amount of thickener is 0-2%, preferably 0.1-2%, more preferably
For 0.1-1%.If the content of thickener is greater than 2%, moisturiser has poor sense of touch due to sticky, stiff.
Moisturiser according to the present invention, wherein skin conditioning agent includes tocopherol acetate, panthenol, Flos Chrysanthemi water, Ku La
Rope aloe leaf juice powder, polypeptide, niacinamide, oat beta-glucan, adenosine, Rosa centifolia flower extract, lavandulae flos water and centella mention
Take the combination of one or more of object.
In terms of the mass percent of the moisturiser, the additional amount of skin conditioning agent is 1-10%, preferably 2-10%, more
Preferably 5-10%；Such as: the additional amount of skin conditioning agent can be 3%, 4%, 5%, 6%, 7%, 8%, 9% etc..Skin
When the additional amount of conditioner is between 1-10%, has the characteristics that releive, repairs skin.
In the present invention, the moisturiser further includes preservative and/or odorant；With the mass percent of the moisturiser
Meter, the additional amount of the preservative are 0.2-3%, preferably 0.2-2%, more preferable 0.2-1.5%；The additional amount of the odorant
For 0-0.2%, preferably 0.01-0.2%, more preferably 0.01-0.15%.
Preferably, the preservative is hexylene glycol, parahydroxyacet-ophenone, Phenoxyethanol, Chlorphenesin, the smooth octanoic acid of sorb
The combination of one or more of ester, benzoic acid, gluconolactone and sodium benzoate.
In the present invention, natural or synthesis dulcet substance or their mixing can be used in the odorant
Object.Natural dulcet substance includes flower class (lily, lavender, rose, jasmine, flores aurantii, Yilan), stem class and leaf class (India
Certain herbaceous plants with big flowers, Pogostemon cablin, orange leaf), fruit class (fennel, Carum carvi, juniperko), shell class (bergamot, lemon, citrus), root class (Pork and beans
Cool, Radix Angelicae Sinensis, celery, cardamom, costus root, iris, thyme), needle and branch class (dragon spruce, fir, pine, illawarra mountain pine) and tree
The extract of rouge and face cream class (galbanum, elemi, styrax, myrrh, olibanum, opopanax).
Typical synthetic perfume compound is ester, ether, aldehyde, ketone, alcohol and hydrocarbon type product.Ester type flavor compounds have for example
Benzyl acetate, phenoxyethyl isobutanoate, acetic acid are to t-butylcyclohexyl base ester, acetic acid linalool, phenethyl acetate, benzoic acid virtue
Camphor tree ester, benzyl formate, phenyl glycine methyl ester, allyl-cyclohexyl base ester, styralyl propionate and benzyl salicylate；Ether
Class flavor compounds include such as benzylisoeugenol；Aldehyde perfume compound includes the straight chain alkane for example with 8-18 carbon atom
Aldehydes, citral, citronellol, lemongrass oxygroup-acetaldehyde, cyclamen aldehyde, laurine, lilial and the clean big vast aldehyde of wave；Ketone
Flavor compounds include such as violet ketone, isomethylionone and vertofix coeur；Alcohols flavor compounds include
Anisole, citronellol, eugenol, isoeugenol, geraniol, linalool, benzyl carbinol and terpinol；And hydro carbons fragrance chemical combination
Object mainly includes terpene and face cream class.
In addition, the volatile oil of low volatility is typically used as aroma constituent, it also is suitable as fragrance, such as sage oil,
Chamomile oil, caryophyllus oil, face cream oil, peppermint oil, cinnamon leaves oil, linden flower oil, juniperko fruit oil, vetiver oil, frankincense oil, wave
This resinon, labdanum oil and lavandin oil.
In the present invention, can individually or be used in mixed way bergamot oil, dihydromyrcenol, lilial, lyral,
Citronellol, benzyl carbinol, α-hexyl-cinnamic acid, geraniol, benzylacetone, cyclamen aldehyde, linalool, imperial saliva radix aucklandiae, imperial saliva furan
It mutters, indoles, dihydrojasmonate, lemon oil, tangerine orange oil, mandarin oil, glycolic allyl amyl ester, lavandin oil, mouse
Tail grass oil, damascone, pelargonium oil, salicylate cyclohexyl ester, vertofix coeur, phenylacetic acid, geranyl acetate, benzyl acetate and rose
Rare ether etc. is used as odorant.
Odorant of the invention can be commercially available, and can also be prepared.
Moisturiser according to the present invention, wherein in the moisturiser, can also add pH adjusting agent, free radical scavenger,
The combination of one or more of other additives such as chelating agent, antioxidant, film forming agent, stabilizer, pigment.
Preferably, the pH adjusting agent includes: sodium hydroxide, potassium hydroxide, triethanolamine, aminomethyl propanol, arginine
One or more of combination.
In addition, also containing a certain amount of water in the present invention, in terms of the mass percent of the moisturiser, the content of water can
To be 10-80%, preferably 20-70%, more preferably 30-60%.
The present invention also provides a kind of preparation method of moisturiser according to the present invention, including by each component of the moisturiser
The step of mixing.
The preparation method of moisturiser of the invention, comprising the following steps:
Grease, partial skin conditioner and emulsifier are mixed, A phase (oily phase) is obtained；
Water, moisturizer and thickener are mixed, B phase (water phase) is obtained；
A phase (oily phase) is added in B phase (water phase), and is emulsified, emulsified body is obtained；
Then C phase is added into emulsified body (that is: remaining skin conditioning agent, odorant, preservative and be optionally present ground
Other additives) after, obtain reaction product.
The preparation method of moisturiser of the invention, specifically includes the following steps:
Grease, partial skin conditioner and emulsifier are put into reactor, in 70~80 DEG C of at a temperature of stirring point
It dissipates uniformly, as A phase (oily phase)；
Water, moisturizer and thickener are put into emulsifier unit, the stirring and dissolving point under the conditions of 70~80 DEG C of temperature
It dissipates uniformly, as B phase (water phase)；
It is mutually at the uniform velocity added in water phase, is added the time 1~3 minute, after addition, with 1000 by oily under agitation
The homogeneous revolving speed of~6000rpm emulsifies 1~5 minute, has emulsified and has been stirred again with the revolving speed of 100~600rpm, has been emulsified
Body；
When temperature is down to 40~45 DEG C, C phase is added into emulsion pot, and (that is: remaining skin conditioning agent, is prevented odorant
Rotten agent and be optionally present other additives), stir evenly；
It stirs evenly, vacuumizes, cool to 30 DEG C hereinafter, discharging, obtains moisturiser.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
It can be with conventional products that are commercially available.
Embodiment 1-5
According to the mass percent of each component in the following table 1, based on total weight 1000g, the moisturizing of embodiment 1-5 is prepared
Frost.
Wherein, -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol (and) cetanol is
By 65wt% by -6 distearate of polyglycereol, 19wt% Jojoba esters, -3 beeswax acid esters of 8wt% polyglycereol and 8wt% whale
Ceryl alcohol composition.
Embodiment 1-5's the preparation method comprises the following steps:
(1) grease, partial skin conditioner (tocopherol acetate) and emulsifier are put into reactor, at 80 DEG C
At a temperature of be dispersed with stirring uniformly, as A phase (oily phase)；
(2) deionized water, moisturizer and thickener are put into emulsifier unit, is stirred under the conditions of 80 DEG C of temperature molten
Solution is uniformly dispersed, as B phase (water phase)；
(3) it is mutually at the uniform velocity added in water phase, is added the time 3 minutes by oily under agitation, after addition, with
The homogeneous revolving speed of 6000rpm emulsifies 3 minutes, has emulsified and has been stirred again with the revolving speed of 100rpm, has obtained emulsified body；
(4) when temperature is down to 40 DEG C, C phase is added to emulsion pot, and (that is: remaining skin conditioning agent is (oat beta-glucan, general
Alcohol), odorant, preservative and be optionally present other additives), stir evenly；
(5) it stirs evenly, and vacuumizes, cool to 30 DEG C, discharging obtains moisturiser.
Table 1
Comparative example 1-6
According to the mass percent of each component in the following table 2, based on total weight 1000g, according to the preparation side of embodiment 1-5
The moisturiser of comparative example 1-6 is prepared in method.
Table 2
Performance test
1, appearance and pH value
The appearance of embodiment 1-5 and comparative example 1-6 are white cream, and pH value is between 5.5-7.5.
2, stability test
The moisturiser of 120g embodiment 1-5 and comparative example 1-6 are respectively taken, and is respectively placed in room temperature, 48 DEG C of incubators, -20 DEG C
Refrigerator and -20 DEG C, -25 DEG C, in -48 DEG C of temperature cycling case, observation in 1 month, observation knot are then carried out to its stability
Fruit is shown in the following table 3.
Table 3
The moisturiser of embodiments herein 1-5 and the moisturiser of comparative example 1-4 it can be seen from the result in upper table 3
Compared to better dosage form stability.Therefore, pass through -6 distearate of compound emulsifying agent polyglycereol in addition emulsifier
- 3 beeswax acid esters of (and) Jojoba esters (and) polyglycereol (and) cetanol, and when emulsifier content is within the scope of the application, energy
Enough further increase dosage form stability.
3, skin patch test
3.1 test material
Tested material: the moisturiser of embodiment 1-5, the moisturiser of comparative example 1-6 and commercially available moisturiser product.
Negative control: blank control
Spot tester: Shanghai Sanitary Material Factory Co., Ltd.+140801
Test equipment: quantitative cylinder rifle (Microman M100+GILSON LCO5239), single channel pipettor
(Transferpette+08N33275)
3.2 test method
Subject: totally 30 subjects；Minimal ages 21 years old, max age 35 years old；29 ± 5.4 years old volunteer of average age
Meet inclusion criteria.
Patch test method: qualified spot tester is selected, in enclosed type patch test method, by tested material about 0.020-
0.025g (moisturiser) is placed in spot tester, and external application medical adhesive tape is pasted on subject back, removes tested material after 24 hours, point
The observation dermoreaction in 0.5,24,48 hour not after removing patch, by skin in " cosmetics safety technical specification " (version in 2015)
Skin reaction grade scale records its result.
3.3 test basis
" cosmetics safety technical specification " (version in 2015) Part V human skin enclosed type patch test skin is bad
Grade scale is reacted, testing result is as shown in table 4.
Specific extent of reaction grading system are as follows:
0 negative reaction；
1 suspicious reaction: only faint erythema；
2 weakly positives react (erythematous response): erythema, infiltration, and oedema can have papule；
3 strong positive reactions (bleb reaction): erythema, infiltration, oedema, papule, bleb: reaction can exceed tested area；
4 extremely strong positive reactions (reaction of amalgamation bleb): obvious erythema, severe infiltration, oedema, amalgamation bleb: reaction
Beyond tested area.
Table 4
From the conclusion of above-mentioned table 4: human skin enclosed type patch test results show, the embodiment of the present invention 1-5
In, 0 there is positive reaction in 30 people.Therefore, according to regulation in " cosmetics safety technical specification " (version in 2015), this is tested
Object will not cause skin adverse reaction to this batch subject.The results show that the moisturiser of the embodiment of the present invention 1-5 is to skin
It is non-stimulated, no positive reaction.And in comparative example 1-6, there is each 1 of suspicious reaction in comparative example 1,3-4；Comparative example 2,5 occurs weak
Positive reaction each 1；There is weakly positive and reacts 2 in commercially available moisturiser.As it can be seen that the present invention has the moisturiser of lasting moistening effect
It is more mild non-stimulated relative to common moisturiser product.
4, both effectiveness test
Test philosophy using German CK moisture of skin tester Corneometer CM825 test moisture be based on water and
Dielectric constant (< 7) variation of other materials is big, and according to the difference of water content, the measuring capacitor of suitable shape can be with skin
The variation of the capacitance of skin and change, and the capacitance of skin measures the moisture content of skin in the range of measurement.
4.1 technical parameter
1. test philosophy: capacitance principle；
2. measuring head area: 7 × 7mm2；
3. probe parameter: length about 11cm；
4. time of measuring frequency: 0.9-1.2MHZ；
5. testing pressure: 1.1-1.5N；
6. precision: ± 3%；
7. numberical range: 0-130；
8. weight: about 41g.
Using German CK moisture of skin tester Corneometer CM825, with above-described embodiment 1-5 and comparative example 1-6
Every kind of moisturiser and commercially available moisturiser be applied to 80 30-40 years old dry skins or firmly believe the women with dry skin
The inner forearm of user.Before application starts, using moisture of skin tester steady temperature and constant humidity (21 DEG C and
40% humidity) under conditions of measure the skin moisture content of each subject, and the initial value as reference value, after measurement application
(T0) and 30 minutes (T1) after application, the variation of the skin moisture content of 4 hours (T2) and 8 hours (T3), test result
As shown in table 5.
Table 5
It can be seen from the test result of table 5 using the moisturiser of embodiment 1-5,30 minutes after use
Skin moisture content increase more, and skin moisture-keeping than the skin moisture content at once of comparative example 1-6, commercially available moisturiser
Performance continues 8 hours or the longer time.In embodiment 4-5, since the content of Butyrospermum parkii fruit rouge is lower, skin moisture content
Increase small compared to the skin moisture content increasing degree of embodiment 1-3.Comparative example 3,4 leads to oil since formulation stability is poor
Rouge separates and emulsifier is destroyed, therefore can not measure skin moisture content.
5, questionnaire survey is tested
30 subjects alleviate with the questionnaire survey of dry skin effect.The effect is assessed using 5 graduation,
Assessed value (5 graduation) is averaged and is shown in the following table 6.
Table 6
1-5 of the embodiment of the present invention has the moisturiser of lasting moistening effect relative to right it can be seen from the result of upper table 6
Have the effect of preferably alleviating dry skin for the moisturiser and commercially available moisturiser of ratio 1,2,5,6.Similarly, due to right
The stability of ratio 3,4 is poor, so that grease separates and emulsifier is destroyed, for these reasons, can not carry out questionnaire tune
It looks into.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. a kind of moisturiser, which is characterized in that in terms of the mass percent of the moisturiser, including following components:
Grease: 5-40%, preferably 10-35%, more preferable 15-35%；
Emulsifier: 2.1-20%, preferably 2.5-10%, more preferable 3-8%；
Moisturizer: 1-40%, preferably 5-30%, more preferable 10-25%；
Thickener: 0-2%, preferably 0.1-2%, more preferable 0.1-1%；
Skin conditioning agent: 1-10%, preferably 2-10%, more preferable 5-10%；
The emulsifier includes compound emulsifying agent, the compound emulsifying agent be -6 distearate of polyglycereol (and) Jojoba esters
(and) -3 beeswax acid esters of polyglycereol (and) cetanol.
2. moisturiser according to claim 1, which is characterized in that the grease includes phytosterol Queensland nut oleic acid
Ester, Butyrospermum parkii fruit rouge, sunflower seed oil, glycerol three (thylhexoic acid) ester, coconut oil, caprylic/capric triglyceride, octyl ten
Glycol myristinate, pentaerythrite four (thylhexoic acid) ester, cetanol ethylhexoate, dimethyl silicone polymer, poly- diformazan
The a combination of one or more of the pure and mild ring five dimethyl silicone polymer of radical siloxane.
3. moisturiser according to claim 1 or 2, which is characterized in that in addition to the compound emulsifying agent, the emulsifier
It further include that lecithin, -6 distearate of polyglycereol, -3 beeswax acid esters of polyglycereol, cetostearyl alcohol olive oleate, sorb are smooth
The combination of one or more of olive oleate, cetostearyl alcohol, acrylic acid (ester) analog copolymer sodium.
4. moisturiser according to claim 1-3, which is characterized in that with the mass percent of the moisturiser
Meter, -3 beeswax acid esters of -6 distearate of polyglycereol (and) Jojoba esters (and) polyglycereol (and) additional amount of cetanol
For 2-6%.
5. moisturiser according to claim 1-4, which is characterized in that the moisturizer include 1,3-PD,
1,2- propylene glycol, pentanediol, sorbierite, glycerol, dipropylene glycol, 1,3 butylene glycol, trehalose, glycine betaine, xylitol, budding are short
Obstruct enzyme polysaccharide, glycerin polyether -26, beta glucan, methyl gluceth -20, methyl gluceth -10, erythrulose, life
The combination of one or more of object carbohydrate gum -1, rhamnose, acetyl chitosamine, polyethylene glycols and Sodium Hyaluronate.
6. moisturiser according to claim 1-5, which is characterized in that the thickener includes carbomer, xanthan
Glue, pectin, Arabic gum natural gum, Scleroglucan, hydroxymethyl cellulose, hydroxyethyl cellulose, acrylic acid (ester) class/C10-30 alkane
The combination of one or more of alcohol acrylate crosspolymers, Chondrus crispus extract and Sodium Polyacrylate.
7. moisturiser according to claim 1-6, which is characterized in that the skin conditioning agent includes tocopherol second
Acid esters, panthenol, Flos Chrysanthemi water, aloe barbadensis Miller leaf juice powder, polypeptide, niacinamide, oat beta-glucan, adenosine, Rosa centifolia are extracted
The combination of one or more of object, lavandulae flos water and Gotu Kola P.E.
8. moisturiser according to claim 1-7, which is characterized in that the moisturiser further include preservative and/
Or odorant；In terms of the mass percent of the moisturiser, the additional amount of the preservative is 0.2-3%, preferably 0.2-2%,
More preferable 0.2-1.5%；The additional amount of the odorant is 0-0.2%, preferably 0.01-0.2%, more preferably 0.01-
0.15%.
9. moisturiser according to claim 1-8, which is characterized in that the moisturiser further include pH adjusting agent,
The combination of one or more of free radical scavenger, chelating agent, antioxidant, film forming agent, stabilizer, pigment.
10. a kind of preparation method of -9 described in any item moisturisers according to claim 1, which is characterized in that including will be described
The step of each component mixing of moisturiser.
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Effective date of registration: 20220112 Address after: No.23, Xianke 2nd Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province, 510890 Patentee after: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee after: Guangdong Danzi Group Co., Ltd; Address before: No.23, Xianke 2nd Road, Huadong Town, Huadu District, Guangzhou City, Guangdong Province, 510890 Patentee before: GUANGZHOU KENENG COSMETIC RESEARCH Co.,Ltd. Patentee before: GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT Patentee before: GUANGDONG DANZ GROUP Co.,Ltd. |